glycochenodeoxycholic acid has been researched along with Bile Duct Obstruction in 29 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (13.79) | 18.7374 |
| 1990's | 6 (20.69) | 18.2507 |
| 2000's | 8 (27.59) | 29.6817 |
| 2010's | 10 (34.48) | 24.3611 |
| 2020's | 1 (3.45) | 2.80 |
| Authors | Studies |
|---|---|
| Beuers, U; Denk, G; Elferink, RO; Hohenester, S; Horst, D; Kanitz, V; Kremer, AE; Kuehn, H; Paulusma, CC; Wimmer, R | 1 |
| Li, H; Liao, M; Liao, Q; Liu, R; Wei, C; Xia, Z; Xiao, X; Yang, M; Yu, H; Zhang, X; Zhao, J; Zhou, Y | 1 |
| Ali, I; Beaudoin, JJ; Bezençon, J; Brouwer, KLR; Malinen, MM | 1 |
| Banales, JM; Briz, O; Herraez, E; Lozano, E; Macias, RI; Marin, JJ; Monte, MJ; Sanchez-Vicente, L | 1 |
| Chamulitrat, W; Pathil, A; Sellinger, M; Stremmel, W; Xu, W | 1 |
| Bronk, SF; Gores, GJ; Lee, H; O'Brien, DK; Wang, L; Yoon, Y; Yu, T | 1 |
| Jaeschke, H; McGill, MR; Woolbright, BL; Yan, H | 1 |
| Albiin, N; Arnelo, U; Bergquist, A; Bezabeh, T; Ijare, OB; Lindberg, B; Smith, IC | 1 |
| Denk, GU; Pusl, T; Rust, C; Thasler, W; Vennegeerts, T; Wimmer, R | 1 |
| Briceño, J; Cruz, A; Fernández-Rodríguez, R; Ferrín, G; Gómez, MA; González, R; López-Cillero, P; Marin, JJ; Martínez-Ruiz, A; Mata, Mde L; Muntané, J; Rufián, S | 1 |
| Briceño, J; Cruz, A; De la Mata, M; Ferrín, G; Gómez, MA; González, R; López-Cillero, P; Marin, JJ; Muntané, J; Padillo, J; Rufián, S | 1 |
| Jaeschke, H; Woolbright, BL | 1 |
| Fischer, R; Graf, D; Häussinger, D; Kircheis, G; Kurz, AK; Reinehr, R | 1 |
| Conde de la Rosa, L; Gommans, WM; Haisma, HJ; Homan, M; Jansen, PL; Klok, P; Moshage, H; Poelstra, K; Schoemaker, MH; Trautwein, C; van Goor, H | 1 |
| Dahl, R; Devereaux, MW; Gumpricht, E; Sokol, RJ | 1 |
| Bauchmuller, K; Beuers, U; Fickert, P; Fuchsbichler, A; Rust, C | 1 |
| Bernt, C; Beuers, U; Rust, C; Vennegeerts, T | 1 |
| Hatano, E; Ikai, I; Iwaisako, K; Kodama, Y; Nakajima, A; Nitta, T; Seo, S; Tada, M; Tamaki, N; Taura, K; Uemoto, S | 1 |
| Bartholomew, C; Billing, BH; Dooley, JS; Summerfield, JA | 1 |
| Billing, BH; Chitranukroh, A | 1 |
| Ayyad, N; Cohen, BI; Hoshita, T; Kihira, K; Mikami, T; Mosbach, EH; Yoshii, M | 1 |
| Bronk, SF; Gores, GJ; Spivey, JR | 1 |
| Gores, GJ; Patel, T | 1 |
| Aguilar, HI; Botla, R; Bronk, SF; Gores, GJ; Miyoshi, H | 1 |
| Bronk, SF; Gores, GJ; Jones, BA; Lieser, MJ; Natori, S; Park, J | 1 |
| Gores, GJ; Mandal, PK; Millikan, RE; Miyoshi, H; Roberts, P; Rust, C; Siegel, R; Takikawa, Y | 1 |
| Li, D; Li, F; Liu, F; Liu, S; Sun, H; Sun, J | 1 |
| Demers, LM; Lloyd-Still, JD | 1 |
| Billing, BH; Chitranukroh, A; Taggart, G | 1 |
1 review(s) available for glycochenodeoxycholic acid and Bile Duct Obstruction
| Article | Year |
|---|---|
Novel insight into mechanisms of cholestatic liver injury.
Topics: Animals; Apoptosis; Bile Acids and Salts; Cholestasis; Glycochenodeoxycholic Acid; Hepatocytes; Humans; Ligation; Necrosis; Signal Transduction | 2012 |
1 trial(s) available for glycochenodeoxycholic acid and Bile Duct Obstruction
| Article | Year |
|---|---|
The biliary excretion of sulphated and non-sulphated bile acids and bilirubin in patients with external bile drainage.
Topics: Aged; Bile; Bile Acids and Salts; Bilirubin; Chenodeoxycholic Acid; Cholestasis; Drainage; Glycochenodeoxycholic Acid; Glycocholic Acid; Humans; Middle Aged; Secretory Rate; Time Factors | 1984 |
27 other study(ies) available for glycochenodeoxycholic acid and Bile Duct Obstruction
| Article | Year |
|---|---|
Glycochenodeoxycholate Promotes Liver Fibrosis in Mice with Hepatocellular Cholestasis.
Topics: Adenosine Triphosphatases; Animals; Cell Proliferation; Cells, Cultured; Cholestasis; Chronic Disease; Collagen; Feeding Behavior; Gene Expression Regulation; Glycochenodeoxycholic Acid; Hepatic Stellate Cells; Hepatocytes; Humans; Hydrophobic and Hydrophilic Interactions; Liver; Liver Cirrhosis; MAP Kinase Signaling System; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase Kinases; Phospholipid Transfer Proteins | 2020 |
Mcl-1 suppresses abasic site repair following bile acid-induced hepatic cellular DNA damage.
Topics: Apurinic Acid; Bile Acids and Salts; Cholestasis; DNA Damage; DNA Repair; DNA-Binding Proteins; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Glycochenodeoxycholic Acid; Hep G2 Cells; Hepatocytes; Humans; Liver Neoplasms; Myeloid Cell Leukemia Sequence 1 Protein; Poly(ADP-ribose) Polymerases; Reactive Oxygen Species; X-ray Repair Cross Complementing Protein 1 | 2017 |
Organic solute transporter OSTα/β is overexpressed in nonalcoholic steatohepatitis and modulated by drugs associated with liver injury.
Topics: Bile Acids and Salts; Biological Transport; Biomarkers; Cell Line; Chemical and Drug Induced Liver Injury; Cholestasis; Female; Glycochenodeoxycholic Acid; Hepatocytes; Humans; Liver; Liver Cirrhosis, Biliary; Male; Membrane Transport Proteins; Middle Aged; Non-alcoholic Fatty Liver Disease; Taurocholic Acid | 2018 |
Cocarcinogenic effects of intrahepatic bile acid accumulation in cholangiocarcinoma development.
Topics: Animals; Apoptosis; Bile Acids and Salts; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Biomarkers, Tumor; Cell Proliferation; Cells, Cultured; Cholangiocarcinoma; Cholestasis; Cholic Acids; Cisplatin; Cocarcinogenesis; Cross-Linking Reagents; DNA Damage; Glycochenodeoxycholic Acid; Hepatocytes; Inflammation; Interleukin-6; Liver; Liver Neoplasms; Male; Promoter Regions, Genetic; Rats; Rats, Wistar; Rec A Recombinases; Receptor, ErbB-2; Receptors, Cytoplasmic and Nuclear; SOS Response, Genetics; Thioacetamide | 2014 |
Ursodeoxycholyl lysophosphatidylethanolamide inhibits cholestasis- and hypoxia-induced apoptosis by upregulating antiapoptosis proteins.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Cell Line, Tumor; Cholestasis; Glycochenodeoxycholic Acid; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Liver; Mice; Myeloid Cell Leukemia Sequence 1 Protein; Phosphatidylethanolamines; Phosphorylation; Up-Regulation; Ursodeoxycholic Acid | 2015 |
Decreasing mitochondrial fission prevents cholestatic liver injury.
Topics: Adenoviridae; Animals; Cell Death; Cell Line; Cholestasis; Common Bile Duct; Dynamins; Gene Expression; Genetic Vectors; Glycochenodeoxycholic Acid; Green Fluorescent Proteins; Hepatocytes; Liver; Liver Cirrhosis; Male; Mice; Mice, Transgenic; Mitochondria, Liver; Mitochondrial Dynamics; Mutation; Organelle Shape; Primary Cell Culture; Reactive Oxygen Species | 2014 |
Bile Acid-Induced Toxicity in HepaRG Cells Recapitulates the Response in Primary Human Hepatocytes.
Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Bile Acids and Salts; Cholestasis; Glycochenodeoxycholic Acid; Hep G2 Cells; Hepatocytes; Humans; JNK Mitogen-Activated Protein Kinases; Mice; Protective Agents; Taurocholic Acid | 2016 |
Absence of glycochenodeoxycholic acid (GCDCA) in human bile is an indication of cholestasis: a 1H MRS study.
Topics: Adult; Aged; Aged, 80 and over; Amides; Bile; Cholestasis; Female; Glycochenodeoxycholic Acid; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Protons | 2009 |
Glycochenodeoxycholate-induced apoptosis is not reduced by augmenter of liver regeneration in the human hepatoma cell line HuH-7.
Topics: Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Line; Cholestasis; Glycochenodeoxycholic Acid; Humans; Liver Neoplasms; Liver Regeneration; Polymerase Chain Reaction; Proteins; Rats; Transfection; Tumor Cells, Cultured | 2010 |
Nitric oxide mimics transcriptional and post-translational regulation during α-tocopherol cytoprotection against glycochenodeoxycholate-induced cell death in hepatocytes.
Topics: Adult; Aged; alpha-Tocopherol; Animals; Cell Death; Cells, Cultured; Cholestasis; Cholesterol 7-alpha-Hydroxylase; Cytoprotection; Disease Models, Animal; Female; Glycochenodeoxycholic Acid; Heme Oxygenase-1; Hepatocytes; Humans; In Vitro Techniques; Male; Membrane Potential, Mitochondrial; Middle Aged; Nitric Oxide; Nitric Oxide Donors; Organic Anion Transporters, Sodium-Dependent; Oxidative Stress; Protein Processing, Post-Translational; Rats; Symporters; Transcription, Genetic | 2011 |
Cytoprotective properties of rifampicin are related to the regulation of detoxification system and bile acid transporter expression during hepatocellular injury induced by hydrophobic bile acids.
Topics: Animals; Apoptosis; Bile Acids and Salts; Carrier Proteins; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cholestasis; Disease Models, Animal; Enzyme Inhibitors; Female; Gene Expression Regulation; Glycochenodeoxycholic Acid; Hepatectomy; Hepatocytes; Humans; Male; Membrane Glycoproteins; Middle Aged; Polymerase Chain Reaction; Rats; Rats, Wistar; Rifampin; RNA, Messenger | 2011 |
Prevention of bile acid-induced apoptosis by betaine in rat liver.
Topics: Animals; Apoptosis; Betaine; Bile Acids and Salts; Cell Membrane; Cells, Cultured; Cholestasis; fas Receptor; Glycochenodeoxycholic Acid; Hepatocytes; In Vitro Techniques; Ligation; Lipotropic Agents; Liver Diseases; Male; Oxidative Stress; Rats; Rats, Wistar; Receptors, TNF-Related Apoptosis-Inducing Ligand; Receptors, Tumor Necrosis Factor; Signal Transduction; Taurolithocholic Acid | 2002 |
Resistance of rat hepatocytes against bile acid-induced apoptosis in cholestatic liver injury is due to nuclear factor-kappa B activation.
Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis; Carrier Proteins; Cells, Cultured; Cholestasis; Cytokines; Disease Models, Animal; Fas-Associated Death Domain Protein; Gene Expression; Glycochenodeoxycholic Acid; Hepatocytes; Male; NF-kappa B; Rats; Rats, Wistar; Specific Pathogen-Free Organisms; Taurochenodeoxycholic Acid | 2003 |
Beta-carotene prevents bile acid-induced cytotoxicity in the rat hepatocyte: Evidence for an antioxidant and anti-apoptotic role of beta-carotene in vitro.
Topics: Animals; Antioxidants; Apoptosis; beta Carotene; Bile Acids and Salts; Caspase 3; Caspases; Cholestasis; Cytochromes c; Cytosol; Enzyme Activation; Flow Cytometry; Glycochenodeoxycholic Acid; Hepatocytes; Immunoblotting; Liver; Membrane Potentials; Mitochondria; Mitochondria, Liver; Necrosis; Oxidative Stress; Rats; Reactive Oxygen Species; Time Factors | 2004 |
Phosphatidylinositol 3-kinase-dependent signaling modulates taurochenodeoxycholic acid-induced liver injury and cholestasis in perfused rat livers.
Topics: Androstadienes; Animals; Bile; Chemical and Drug Induced Liver Injury; Cholestasis; Enzyme Activation; Glycochenodeoxycholic Acid; In Vitro Techniques; Liver Diseases; Perfusion; Phosphatidylinositol 3-Kinases; Protein Kinase Inhibitors; Rats; Signal Transduction; Taurochenodeoxycholic Acid; Wortmannin | 2005 |
The human transcription factor AP-1 is a mediator of bile acid-induced liver cell apoptosis.
Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Bile Acids and Salts; Cell Line; Cell Line, Tumor; Cholestasis; Curcumin; Detergents; Dose-Response Relationship, Drug; Enzyme Inhibitors; Genes, Reporter; Glycochenodeoxycholic Acid; Hepatocytes; Humans; Immunoblotting; Liver; Luciferases; MAP Kinase Signaling System; Oligonucleotide Array Sequence Analysis; p38 Mitogen-Activated Protein Kinases; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Taurocholic Acid; Time Factors; Transcription Factor AP-1; Transcription, Genetic; Up-Regulation | 2006 |
CHOP deficiency attenuates cholestasis-induced liver fibrosis by reduction of hepatocyte injury.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Caspase 3; CCAAT-Enhancer-Binding Proteins; Cells, Cultured; Cholagogues and Choleretics; Cholestasis; Endoplasmic Reticulum; Glycochenodeoxycholic Acid; Hepatocytes; Immunohistochemistry; Ligation; Liver; Liver Cirrhosis; Mice; Mice, Inbred C57BL; Mice, Knockout; Necrosis; Reverse Transcriptase Polymerase Chain Reaction; Transforming Growth Factor beta1 | 2008 |
Changes in the binding of radioactive conjugated bile salts to serum proteins in cholestatic jaundice.
Topics: Bile Acids and Salts; Bilirubin; Blood Proteins; Cholestasis; Glycochenodeoxycholic Acid; Glycocholic Acid; Humans; Protein Binding | 1983 |
Synthesis and metabolism of sodium 3 alpha,7 alpha-dihydroxy-25,26-bishomo-5 beta-cholane-26-sulfonate in the hamster.
Topics: Animals; Chenodeoxycholic Acid; Cholestasis; Cricetinae; Glycochenodeoxycholic Acid; Intestinal Absorption; Liver; Male; Mesocricetus; Molecular Structure | 1995 |
Glycochenodeoxycholate-induced lethal hepatocellular injury in rat hepatocytes. Role of ATP depletion and cytosolic free calcium.
Topics: Adenosine Triphosphate; Animals; Calcium; Cell Survival; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cholestasis; Cytosol; Glycochenodeoxycholic Acid; Hydrogen-Ion Concentration; In Vitro Techniques; Intracellular Membranes; Male; Membrane Potentials; Mitochondria, Liver; Proteins; Rats; Rats, Sprague-Dawley | 1993 |
Inhibition of bile-salt-induced hepatocyte apoptosis by the antioxidant lazaroid U83836E.
Topics: Animals; Antioxidants; Apoptosis; Cell Nucleus; Cells, Cultured; Cholestasis; Chromans; DNA Fragmentation; Glycochenodeoxycholic Acid; Lipid Peroxidation; Liver; Oxidative Stress; Piperazines; Rats | 1997 |
Induction of the mitochondrial permeability transition as a mechanism of liver injury during cholestasis: a potential role for mitochondrial proteases.
Topics: Animals; ATP-Dependent Proteases; Calcium Channels; Calpain; Cholestasis; Enzyme Activation; Glycochenodeoxycholic Acid; Liver; Mitochondria, Liver; Necrosis; Permeability; Serine Endopeptidases; Ursodeoxycholic Acid | 1998 |
Cholestasis confers resistance to the rat liver mitochondrial permeability transition.
Topics: Animals; Apoptosis; bcl-X Protein; Bile Ducts; Cardiolipins; Cell Survival; Cholestasis; Cytochrome c Group; Glycochenodeoxycholic Acid; Humans; Intracellular Membranes; Lipid Peroxidation; Liver; Male; Mitochondria, Liver; Permeability; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Inbred F344; Thiobarbituric Acid Reactive Substances | 1998 |
The bile acid-activated phosphatidylinositol 3-kinase pathway inhibits Fas apoptosis upstream of bid in rodent hepatocytes.
Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis; BH3 Interacting Domain Death Agonist Protein; Carrier Proteins; Caspase 8; Caspase 9; Caspases; Cholestasis; Cytochrome c Group; Enzyme Activation; Enzyme Precursors; fas Receptor; Fas-Associated Death Domain Protein; Glycochenodeoxycholic Acid; Male; Mice; Mice, Inbred C57BL; Mitochondria; Phosphatidylinositol 3-Kinases; Taurodeoxycholic Acid | 2001 |
[Bile salt induces apoptosis of hepatocytes: the mechanism of hepatic function injury during obstructive jaundice].
Topics: Animals; Apoptosis; Bile Acids and Salts; Cholestasis; Dose-Response Relationship, Drug; Female; Glycochenodeoxycholic Acid; Hepatocytes; Humans; In Situ Nick-End Labeling; Liver; Rats; Rats, Sprague-Dawley | 1998 |
Serum glycine-conjugated bile acids in pediatric hepatobiliary disorders.
Topics: Adolescent; Bile Acids and Salts; Child; Child, Preschool; Cholestasis; Cystic Fibrosis; Diarrhea, Infantile; Glycochenodeoxycholic Acid; Glycocholic Acid; Glycodeoxycholic Acid; Hepatitis; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Intestinal Diseases; Liver Diseases; Reye Syndrome | 1979 |
Enhancement of the urinary excretion of non-sulphated and sulphated radioactive bile acids by sodium acetate in the bile duct obstructed rat.
Topics: Acetates; Acetic Acid; Animals; Bile Acids and Salts; Cholestasis; Glomerular Filtration Rate; Glycochenodeoxycholic Acid; Glycocholic Acid; Kidney Function Tests; Male; Probenecid; Protein Binding; Rats; Rats, Inbred Strains; Stimulation, Chemical; Taurocholic Acid; Urodynamics | 1985 |