glycine has been researched along with Tay-Sachs Disease in 4 studies
Tay-Sachs Disease: An autosomal recessive neurodegenerative disorder characterized by the onset in infancy of an exaggerated startle response, followed by paralysis, dementia, and blindness. It is caused by mutation in the alpha subunit of the HEXOSAMINIDASE A resulting in lipid-laden ganglion cells. It is also known as the B variant (with increased HEXOSAMINIDASE B but absence of hexosaminidase A) and is strongly associated with Ashkenazic Jewish ancestry.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| GEROK, W | 1 |
| PABST, K | 1 |
| Lemieux, MJ | 1 |
| Mark, BL | 1 |
| Cherney, MM | 1 |
| Withers, SG | 1 |
| Mahuran, DJ | 2 |
| James, MN | 1 |
| Brown, CA | 1 |
| Trop, I | 1 |
| Kaplan, F | 1 |
| Brown, C | 1 |
| Mahuran, D | 1 |
| Hechtman, P | 1 |
1 review available for glycine and Tay-Sachs Disease
| Article | Year |
|---|---|
[ON THE PATHOPHYSIOLOGY AND CLINICAL MANIFESTATIONS OF DISORDERS OF RENAL TUBULAR PARTIAL FUNCTION].
Topics: Acidosis; Acidosis, Renal Tubular; Amino Acids; Cystinuria; Diabetes Insipidus; Glycine; Glycosuria; | 1965 |
3 other studies available for glycine and Tay-Sachs Disease
| Article | Year |
|---|---|
Crystallographic structure of human beta-hexosaminidase A: interpretation of Tay-Sachs mutations and loss of GM2 ganglioside hydrolysis.
Topics: Acetylglucosamine; Amino Acid Substitution; Arginine; Aspartic Acid; beta-N-Acetylhexosaminidases; B | 2006 |
beta-Hexosaminidase isozymes from cells cotransfected with alpha and beta cDNA constructs: analysis of the alpha-subunit missense mutation associated with the adult form of Tay-Sachs disease.
Topics: Adult; Animals; Base Sequence; beta-N-Acetylhexosaminidases; Blotting, Western; Cells, Cultured; Chr | 1993 |
A glycine250--> aspartate substitution in the alpha-subunit of hexosaminidase A causes juvenile-onset Tay-Sachs disease in a Lebanese-Canadian family.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Base Sequence; beta-N-Acetylhexosaminidases; Canada; Ce | 1992 |