glycine has been researched along with Seizures in 248 studies
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Central nervous system (CNS) complications such as seizures and reduced consciousness are important in glufosinate and may occur in severe glyphosate poisoning." | 7.85 | Serum S100 protein could predict altered consciousness in glyphosate or glufosinate poisoning patients. ( Choi, YJ; Gil, HW; Hong, SY; Lee, JW; Park, S; Song, HY, 2017) |
| " The patient was found to have glycine encephalopathy resulting from a previously defined mutation in the GLDC gene." | 7.80 | Diagnosis of glycine encephalopathy in a pediatric patient by detection of a GLDC mutation during initial next generation DNA sequencing. ( Adıyaman, G; Biberoğlu, G; Çiftci, B; Ezgu, F; Gökmenoğlu, H; Hasanoğlu, A; Kasapkara, Ç; Küçükçongar, A; Topçu, B; Tümer, L, 2014) |
| "Latrunculin A microperfusion of the hippocampus induces acute epileptic seizures and long-term biochemical changes leading to spontaneous seizures." | 7.80 | Effects of eslicarbazepine acetate on acute and chronic latrunculin A-induced seizures and extracellular amino acid levels in the mouse hippocampus. ( Loureiro, AI; Sierra-Marcuño, G; Sierra-Paredes, G; Soares-da-Silva, P; Wright, LC, 2014) |
| " The results showed that MPEP or DCG-IV combined with HI-6 and procyclidine resulted in substantial antidotal efficacy when administered 20 min after onset of seizures elicited by soman." | 7.79 | Capacities of metabotropic glutamate modulators in counteracting soman-induced seizures in rats. ( Aas, P; Enger, S; Mariussen, E; Myhrer, T, 2013) |
| "This study was aimed at investigating the anticonvulsant activity of lipoic acid (LA) against pilocarpine-induced seizures as well as the effects of this metabolic antioxidant on the hippocampal extracellular concentrations of amino acid neurotransmitters glutamate, aspartate, glycine and glutamate and γ-aminobutyric acid (GABA)." | 7.77 | Lipoic acid alters amino acid neurotransmitters content in rat hippocampus after pilocarpine-induced seizures. ( de Freitas, RM; de Oliveira Silva, F; Jordán, J; Saldanha, GB, 2011) |
| "The present study has examined the anticonvulsant and neuroprotective effect of (S)-3,4-dicarboxyphenylglycine ((S)-3,4-DCPG), a highly selective agonist for subtype 8 of group III metabotropic glutamate receptors (mGluRs), against seizures induced in immature 12-day-old rats by bilateral icv infusion of DL-homocysteic acid (DL-HCA, 600 nmol/side)." | 7.74 | Anticonvulsant and neuroprotective effect of (S)-3,4-dicarboxyphenylglycine against seizures induced in immature rats by homocysteic acid. ( Druga, R; Folbergrová, J; Haugvicová, R; Mares, P; Otáhal, J, 2008) |
| "The potential anticonvulsant effect of group III metabotropic glutamate receptor (mGluR) agonist (R,S)-4-phosphonophenylglycine ((R,S)-PPG) against seizures induced in immature 12-day-old rats by bilateral intracerebroventricular (icv) infusion of DL-homocysteic acid (DL-HCA, 600 nmol/side) was examined in the present study." | 7.72 | Seizures induced by homocysteic acid in immature rats are prevented by group III metabotropic glutamate receptoragonist (R,S)-4-phosphonophenylglycine. ( Folbergrová, J; Haugvicová, R; Mares, P, 2003) |
| "The relation between changes in the concentrations of some of the neuroactive extracellular amino acids (glutamate, aspartate, gamma-aminobutyric acid, glycine and taurine) and epileptic seizures has been tested in a new experimental model of seizures induced by picrotoxin microdialysis in chronic freely moving rats." | 7.70 | Extracellular amino acids in the rat hippocampus during picrotoxin threshold seizures in chronic microdialysis experiments. ( Aguilar-Veiga, E; Galán-Valiente, J; Mendez-Alvarez, E; Sierra-Marcuño, G; Sierra-Paredes, G; Soto-Otero, R; Vazquez-Illanes, MD, 1998) |
| "An asphyxiated neonate with pyridoxine-dependent seizures and associated transient nonketotic hyperglycinemia is reported." | 7.70 | Transient nonketotic hyperglycinemia in an asphyxiated patient with pyridoxine-dependent seizures. ( Goto, K; Inutsuka, M; Izumi, T; Maeda, T, 2000) |
| "This study evaluated a possible mechanism by which glycine potentiates the activity of diazepam (DZP) and valproic acid (VAL) against the clonic seizures induced by pentylenetetrazol (PTZ) in rats." | 7.69 | Diazepam potentiation by glycine in pentylenetetrazol seizures is antagonized by 7-chlorokynurenic acid. ( Peterson, SL, 1994) |
| "This study evaluated a possible mechanism by which glycine potentiates the activity of anticonvulsant drugs against maximal electroshock seizures in rats." | 7.68 | Anticonvulsant drug potentiation by glycine in maximal electroshock seizures is mimicked by D-serine and antagonized by 7-chlorokynurenic acid. ( Peterson, SL, 1991) |
| "This study evaluates the glycine potentiation of anticonvulsant drugs in subcutaneous pentylenetetrazol seizures in rats." | 7.68 | Glycine potentiation of anticonvulsant drugs in pentylenetetrazol seizures in rats. ( Peterson, SL, 1991) |
| "This study evaluated the potentiation by glycine of anticonvulsant drugs in maximal electroshock seizures in rats." | 7.68 | Potentiation by glycine of anticonvulsant drugs in maximal electroshock seizures in rats. ( Adams, HR; Frye, GD; Peterson, SL; Trzeciakowski, JP, 1990) |
| " Metabolic changes associated with kainic acid seizures predominate in the hippocampus, where there are decreases in aspartate (-26%), glutamate (-45%), taurine (-20%), and glutamine (-32%) concentrations and an increase in gamma-aminobutyric acid (GABA) concentration (+ 26%)." | 7.67 | Changes in regional neurotransmitter amino acid levels in rat brain during seizures induced by L-allylglycine, bicuculline, and kainic acid. ( Chapman, AG; Meldrum, BS; Premachandra, M; Westerberg, E, 1984) |
| " The purpose of the present study was to determine whether these compounds can antagonize strychnine-induced seizures when administered intraperitoneally and to compare their effects with those of sarcosine (N-methylglycine) and glycine." | 7.67 | Prevention of strychnine-induced seizures and death by the N-methylated glycine derivatives betaine, dimethylglycine and sarcosine. ( Freed, WJ, 1985) |
| " The behavioral response to the administration of the glycine antagonist, strychnine, was also evaluated in 2- and 24-month-old animals to investigate the relevance of these parameters to the susceptibility to seizures." | 7.67 | Age-dependent changes in brain glycine concentration and strychnine-induced seizures in the rat. ( Chung, E; Hunter, C; Van Woert, MH, 1989) |
| "Patients with nonketotic hyperglycinemia generally have intractable seizures that are poorly responsive to anticonvulsant medication." | 7.67 | The effectiveness of benzoate in the management of seizures in nonketotic hyperglycinemia. ( Kulovich, S; Nyhan, WL; Qiao, CN; Wolff, JA; Yu, AL, 1986) |
| "The ability of betaine to block homocysteine, pentylenetetrazol, and electroshock induced seizures in mice has previously been observed." | 7.67 | Effects of betaine on seizures in the rat. ( Freed, WJ; Ghoz, EH, 1985) |
| "In rabbits, generalized seizures were induced by methoxypyridoxine, and changes in amino acid concentrations of 15 brain regions were investigated before seizure onset and during the course of sustained epileptiform activity." | 7.66 | Alterations in the content of amino acid neurotransmitters before the onset and during the course of methoxypyridoxine-induced seizures in individual rabbit brain regions. ( Haug, P; Nitsch, C; Schmude, B, 1983) |
| "Strychnine poisoning results in a predictable and treatable sequence of events involving blockade of the inhibitory neurotransmitter, extensor muscle spasms, seizures, and respiratory paralysis." | 7.66 | Strychnine poisoning. Recovery from profound lactic acidosis, hyperthermia, and rhabdomyolysis. ( Boyd, RE; Brennan, PT; Deng, JF; Rochester, DF; Spyker, DA, 1983) |
| "Seizures were induced by bilateral intracerebroventricular (i." | 5.33 | Neuroprotective effect of (R, S)-4-phosphonophenylglycine against neuronal damage associated with homocysteic acid-induced seizures in immature rats. ( Folbergrová, J; Haugvicová, R; Langmeier, M; Riljak, V, 2006) |
| "Generalised clonic--tonic seizures were completely suppressed and the metabolic changes were markedly ameliorated, there being only a 1." | 5.31 | Attenuation of seizures induced by homocysteic acid in immature rats by metabotropic glutamate group II and group III receptor agonists. ( Folbergrová, J; Haugvicová, R; Mares, P, 2001) |
| "Patients are affected with congenital microcephaly, psychomotor retardation, and intractable seizures." | 5.30 | Beneficial effects of L-serine and glycine in the management of seizures in 3-phosphoglycerate dehydrogenase deficiency. ( Berger, R; Blau, N; de Koning, TJ; Dorland, L; Duran, M; Gooskens, R; Jaeken, J; Poll-The, BT; Van Schaftingen, E, 1998) |
| "It also prevented pentylenetetrazol seizures in rats in a four times lower dose." | 5.27 | Antagonism of seizures induced by the administration of the endogenous convulsant quinolinic acid into rat brain ventricles. ( Kiseleva, IP; Lapin, IP; Prakhie, IB, 1986) |
| "In mice, running, clonic and tonic convulsions and lethality were assessed following transcorneal (electroshock) current or convulsant drugs, each administered alone and after cannabidiol (CBD) pretreatment." | 5.26 | Effects of cannabidiol on behavioral seizures caused by convulsant drugs or current in mice. ( Benedito, MA; Carlini, EA; Consroe, P; Leite, JR; Mechoulam, R, 1982) |
| "Myoclonic seizures of the hindlegs are induced in mice by l- and d,l-kynurenine." | 5.26 | Kynurenines and seizures. ( Lapin, IP, 1981) |
| "Kynurenine seizures are suggested to be related to the action of kynurenine on glycine receptors in the central nervous system." | 5.26 | Antagonism of L-glycine to seizures induced by L-kynurenine, quinolinic acid and strychnine in mice. ( Lapin, IP, 1981) |
| "In mice, the ED(50) values for seizures following intraperitoneal injection were allylglycine 1." | 5.25 | Seizures induced by allylglycine, 3-mercaptopropionic acid and 4-deoxypyridoxine in mice and photosensitive baboons, and different modes of inhibition of cerebral glutamic acid decarboxylase. ( Horton, RW; Meldrum, BS, 1973) |
| "Relative to wild-type (WT) mice, the tremor mice presented: increased tremors and bradykinesia associated with postural instability, decreased range of motion, and difficulty in initiating voluntary movements directly proportional to age; reduced step length for right and left hindlimbs; reduced cortical GABA, glutamate and, aspartate levels, the DOPAC/DA and ratio and increased the NOR levels; in the striatum, the levels of glycine and aspartate were reduced while the HVA levels, the HVA/DA and 5HIAA/5-HT ratios increased; in the cerebellum the glycine, NOR and 5-HIAA levels increased." | 4.31 | Progressive tremor and motor impairment in seizure-prone mutant tremor mice are associated with neurotransmitter dysfunction. ( Alexandre-Ribeiro, SR; Bernardi, MM; Bondan, EF; Coque, AC; Flório, JC; Garcia-Gomes, MSA; Gonçalves, FB; Kirsten, TB; Lebrun, I; Massironi, SMG; Mori, CMC; Sandini, TM; Silva-Sampaio, AC, 2023) |
| "Nonketotic hyperglycinemia (NKH) or glycine encephalopathy is an autosomal recessive disorder of glycine metabolism resulting in an excessive accumulation of glycine in all body tissues, including the central nervous system." | 3.91 | Nonketotic Hyperglycinemia: Two Case Reports and Review. ( Al Futaisi, A; Al Murshidi, F; Al Thihli, K; Poothrikovil, RP, 2019) |
| "Central nervous system (CNS) complications such as seizures and reduced consciousness are important in glufosinate and may occur in severe glyphosate poisoning." | 3.85 | Serum S100 protein could predict altered consciousness in glyphosate or glufosinate poisoning patients. ( Choi, YJ; Gil, HW; Hong, SY; Lee, JW; Park, S; Song, HY, 2017) |
| "Hyperammonemia is a common finding in children with methylmalonic acidemia." | 3.83 | A neuronal disruption in redox homeostasis elicited by ammonia alters the glycine/glutamate (GABA) cycle and contributes to MMA-induced excitability. ( Braga, DV; da Silva, AM; da Silva, LR; da Silveira Junior, ME; de Oliveira Ferreira, AP; Della-Pace, ID; Dobrachinski, F; Fighera, MR; Furian, AF; Gabbi, P; Grisólia, AB; Marchesan, S; Oliveira, MS; Ribeiro, LR; Rodrigues, FS; Royes, LF; Soares, FA, 2016) |
| " The patient was found to have glycine encephalopathy resulting from a previously defined mutation in the GLDC gene." | 3.80 | Diagnosis of glycine encephalopathy in a pediatric patient by detection of a GLDC mutation during initial next generation DNA sequencing. ( Adıyaman, G; Biberoğlu, G; Çiftci, B; Ezgu, F; Gökmenoğlu, H; Hasanoğlu, A; Kasapkara, Ç; Küçükçongar, A; Topçu, B; Tümer, L, 2014) |
| "Latrunculin A microperfusion of the hippocampus induces acute epileptic seizures and long-term biochemical changes leading to spontaneous seizures." | 3.80 | Effects of eslicarbazepine acetate on acute and chronic latrunculin A-induced seizures and extracellular amino acid levels in the mouse hippocampus. ( Loureiro, AI; Sierra-Marcuño, G; Sierra-Paredes, G; Soares-da-Silva, P; Wright, LC, 2014) |
| " The results showed that MPEP or DCG-IV combined with HI-6 and procyclidine resulted in substantial antidotal efficacy when administered 20 min after onset of seizures elicited by soman." | 3.79 | Capacities of metabotropic glutamate modulators in counteracting soman-induced seizures in rats. ( Aas, P; Enger, S; Mariussen, E; Myhrer, T, 2013) |
| "This study was aimed at investigating the anticonvulsant activity of lipoic acid (LA) against pilocarpine-induced seizures as well as the effects of this metabolic antioxidant on the hippocampal extracellular concentrations of amino acid neurotransmitters glutamate, aspartate, glycine and glutamate and γ-aminobutyric acid (GABA)." | 3.77 | Lipoic acid alters amino acid neurotransmitters content in rat hippocampus after pilocarpine-induced seizures. ( de Freitas, RM; de Oliveira Silva, F; Jordán, J; Saldanha, GB, 2011) |
| " The results indicate that pretreatment with Parawixin 10 prevents the onset of seizures induced with kainic acid, N-methyl-D-aspartate, and pentylenetetrazole in a dose-response manner." | 3.77 | Neurobiological activity of Parawixin 10, a novel anticonvulsant compound isolated from Parawixia bistriata spider venom (Araneidae: Araneae). ( Beleboni, RO; Coutinho-Netto, J; Cunha, AO; dos Santos, WF; Fachim, HA; Gobbo-Neto, L; Lopes, NP; Pereira, AC, 2011) |
| "The anticonvulsant effects of D-cycloserine, which is a partial agonist of the glycine/N-methyl-D-aspartate (NMDA) receptor, and L-701,324, which is a selective and potent antagonist that acts at the glycine site, were studied in electroshock-induced seizures in mice." | 3.77 | Differential effects of glycine on the anticonvulsant activity of D-cycloserine and L-701,324 in mice. ( Poleszak, E; Wlaź, P, 2011) |
| "Examination of critical subreceptors in the seizure controlling perirhinal cortex has revealed that microinfusion of ionotropic glutamatergic antagonists can exert anticonvulsant efficacy against soman-induced seizures." | 3.76 | Modulators of metabotropic glutamate receptors microinfused into perirhinal cortex: anticonvulsant effects in rats challenged with soman. ( Aas, P; Enger, S; Myhrer, T, 2010) |
| " Furthermore, pretreatment with sarcosine was effective in controlling pentylenetetrazol-induced seizures." | 3.74 | Glycine uptake regulates hippocampal network activity via glycine receptor-mediated tonic inhibition. ( Fei, D; Gong, N; Xu, L; Xu, TL; Zhang, LH, 2008) |
| "The present study has examined the anticonvulsant and neuroprotective effect of (S)-3,4-dicarboxyphenylglycine ((S)-3,4-DCPG), a highly selective agonist for subtype 8 of group III metabotropic glutamate receptors (mGluRs), against seizures induced in immature 12-day-old rats by bilateral icv infusion of DL-homocysteic acid (DL-HCA, 600 nmol/side)." | 3.74 | Anticonvulsant and neuroprotective effect of (S)-3,4-dicarboxyphenylglycine against seizures induced in immature rats by homocysteic acid. ( Druga, R; Folbergrová, J; Haugvicová, R; Mares, P; Otáhal, J, 2008) |
| " This study shows that substitution on the N-terminus confers the greatest antiseizure activity, particularly against pilocarpine-induced seizures." | 3.72 | N-, alpha-, and beta-Substituted 3-Aminopropionic acids: design, syntheses and antiseizure activities. ( Tan, CY; Wainman, D; Weaver, DF, 2003) |
| "The potential anticonvulsant effect of group III metabotropic glutamate receptor (mGluR) agonist (R,S)-4-phosphonophenylglycine ((R,S)-PPG) against seizures induced in immature 12-day-old rats by bilateral intracerebroventricular (icv) infusion of DL-homocysteic acid (DL-HCA, 600 nmol/side) was examined in the present study." | 3.72 | Seizures induced by homocysteic acid in immature rats are prevented by group III metabotropic glutamate receptoragonist (R,S)-4-phosphonophenylglycine. ( Folbergrová, J; Haugvicová, R; Mares, P, 2003) |
| " Intrahippocampal mGluR group I agonist perfusion via a microdialysis probe [1 mm (R,S)-3,5-dihydroxyphenylglycine] induced seizures and concomitant augmentations in amino acid dialysate levels." | 3.72 | In vivo modulation of extracellular hippocampal glutamate and GABA levels and limbic seizures by group I and II metabotropic glutamate receptor ligands. ( Clinckers, R; Ebinger, G; Lindekens, H; Lodge, D; Meurs, A; Michotte, Y; O'Neill, MJ; Smolders, I, 2004) |
| "Glycine encephalopathy, also known as nonketotic hyperglycinemia (NKH), is an autosomal recessive disorder caused by a defect in the glycine cleavage system." | 3.72 | Natural history of nonketotic hyperglycinemia in 65 patients. ( Applegarth, D; Hamosh, A; Hoover-Fong, JE; Shah, S; Toone, J; Van Hove, JL, 2004) |
| "Congenital microcephaly, intractable seizures and severe psychomotor retardation characterize 3-phosphoglycerate dehydrogenase (3-PGDH) deficiency, a disorder of L-serine biosynthesis." | 3.71 | Congenital microcephaly and seizures due to 3-phosphoglycerate dehydrogenase deficiency: outcome of treatment with amino acids. ( De Koning, TJ; Dorland, L; Duran, M; Gooskens, R; Jaeken, J; Pineda, M; Poll-The, BT; Van Maldergem, L, 2002) |
| " Continuous microperfusion of the antagonist for the glycine binding site in NMDA receptors 5,7-dichlorokynurenic acid (100 microM) reversed the effect of both glutamate (1 mM) and glycine (1 mM) and suppressed seizures completely in 90% of the animals." | 3.71 | Effect of extracellular long-time microperfusion of high concentrations of glutamate and glycine on picrotoxin seizure thresholds in the hippocampus of freely moving rats. ( Senra-Vidal, A; Sierra-Marcuño, G; Sierra-Paredes, G, 2001) |
| "The metabotropic Group III agonist, (1S,3R,4S)-1-aminocyclopentane-1,2,4-tricarboxylic acid (ACPT-1), selective for the mGlu(4alpha) receptor, suppresses sound-induced seizures in DBA/2 mice following its intracerebroventricular (i." | 3.71 | Anticonvulsant activity of a mGlu(4alpha) receptor selective agonist, (1S,3R,4S)-1-aminocyclopentane-1,2,4-tricarboxylic acid. ( Chapman, AG; Meldrum, BS; Talebi, A; Yip, PK, 2001) |
| "In mice VGD afforded complete protection against maximal electroshock (MES)-, pentylenetetrazole-, picrotoxin-, and bicuculline-induced seizures and 6-Hz "psychomotor" seizures with median effective dose (ED50) values of 151, 132, 275, 248, and 237 mg/kg, respectively." | 3.71 | Anticonvulsant profile of valrocemide (TV1901): a new antiepileptic drug. ( Bialer, M; Isoherranen, N; White, HS; Woodhead, JH, 2001) |
| "These outcomes suggest that benzoate and dextromethorphan are not uniformly effective in nonketotic hyperglycinemia, but for some patients they improve arousal, decrease or eliminate seizures, and allow for some developmental progress." | 3.70 | Long-term use of high-dose benzoate and dextromethorphan for the treatment of nonketotic hyperglycinemia. ( Bellus, GA; Hamosh, A; Johnston, MV; Maher, JF; Rasmussen, SA, 1998) |
| "The relation between changes in the concentrations of some of the neuroactive extracellular amino acids (glutamate, aspartate, gamma-aminobutyric acid, glycine and taurine) and epileptic seizures has been tested in a new experimental model of seizures induced by picrotoxin microdialysis in chronic freely moving rats." | 3.70 | Extracellular amino acids in the rat hippocampus during picrotoxin threshold seizures in chronic microdialysis experiments. ( Aguilar-Veiga, E; Galán-Valiente, J; Mendez-Alvarez, E; Sierra-Marcuño, G; Sierra-Paredes, G; Soto-Otero, R; Vazquez-Illanes, MD, 1998) |
| " The group I mGluR antagonist 1-aminoindan-1,5-dicarboxylic acid (AIDA) dose-dependently antagonised PTZ-induced seizures with a mean ED50 value of 465 nmol." | 3.70 | Roles of metabotropic glutamate receptor subtypes in modulation of pentylenetetrazole-induced seizure activity in mice. ( Dalby, NO; Thomsen, C, 1998) |
| " We have used intracerebroventricular administration to test a novel group III agonist, (R,S)-4-phosphonophenylglycine (PPG), that is preferential for mglu(8), against sound-induced seizures in DBA/2 mice." | 3.70 | Anticonvulsant activity of a metabotropic glutamate receptor 8 preferential agonist, (R,S)-4-phosphonophenylglycine. ( Chapman, AG; Meldrum, BS; Nanan, K; Yip, P, 1999) |
| "An asphyxiated neonate with pyridoxine-dependent seizures and associated transient nonketotic hyperglycinemia is reported." | 3.70 | Transient nonketotic hyperglycinemia in an asphyxiated patient with pyridoxine-dependent seizures. ( Goto, K; Inutsuka, M; Izumi, T; Maeda, T, 2000) |
| " Clonic seizures induced by the selective mGlu5 agonist, (R,S)-2-chloro-5-hydroxyphenylglycine (CHPG), 3 micromol intracerebroventricularly (i." | 3.70 | Anticonvulsant activity of two metabotropic glutamate group I antagonists selective for the mGlu5 receptor: 2-methyl-6-(phenylethynyl)-pyridine (MPEP), and (E)-6-methyl-2-styryl-pyridine (SIB 1893). ( Chapman, AG; Meldrum, BS; Nanan, K; Williams, M, 2000) |
| "The anticonvulsant activity of felbamate against sound-induced seizures was studied in the DBA/2 mouse model." | 3.69 | Excitatory amino acid neurotransmission through both NMDA and non-NMDA receptors is involved in the anticonvulsant activity of felbamate in DBA/2 mice. ( Aguglia, U; Bertorelli, R; De Sarro, A; De Sarro, G; Ongini, E, 1994) |
| "Glycine blocked the anticonvulsant effects of felbamate on electroshock- and NMDA-induced seizures in mice." | 3.69 | Selective antagonism of the anticonvulsant effects of felbamate by glycine. ( Barnett, A; Coffin, V; Cohen-Williams, M, 1994) |
| "This study evaluated a possible mechanism by which glycine potentiates the activity of diazepam (DZP) and valproic acid (VAL) against the clonic seizures induced by pentylenetetrazol (PTZ) in rats." | 3.69 | Diazepam potentiation by glycine in pentylenetetrazol seizures is antagonized by 7-chlorokynurenic acid. ( Peterson, SL, 1994) |
| "Therapy with benzoic acid in a case of classic neonatal non-ketotic hyperglycinaemia (NKH) was successful in stopping seizures but not in promoting mental development." | 3.69 | Response to sodium benzoate treatment in non-ketotic hyperglycinaemia. ( Hobusch, D; Krüger, G; Radke, M; Stolpe, HJ; Tittelbach-Helmrich, W; Uhlemann, M; Walther, F, 1994) |
| "The effects of valproate on CNS concentrations of gamma-aminobutyric acid (GABA), glulamate (GLU), glutamine (GLN); dopamine (DA), serotonin (5-HT), and metabolites were examined in tissue extracts of caudate nucleus of genetic substrains of Balb/c mice susceptible (EP) or resistant (ER) to audiogenic seizures." | 3.69 | Effects of valproate on amino acid and monoamine concentrations in striatum of audiogenic seizure-prone Balb/c mice. ( Alexiuk, NA; Vriend, JP, 1996) |
| "This study evaluated a possible mechanism by which glycine potentiates the activity of anticonvulsant drugs against maximal electroshock seizures in rats." | 3.68 | Anticonvulsant drug potentiation by glycine in maximal electroshock seizures is mimicked by D-serine and antagonized by 7-chlorokynurenic acid. ( Peterson, SL, 1991) |
| "This study evaluates the glycine potentiation of anticonvulsant drugs in subcutaneous pentylenetetrazol seizures in rats." | 3.68 | Glycine potentiation of anticonvulsant drugs in pentylenetetrazol seizures in rats. ( Peterson, SL, 1991) |
| "Vigabatrin, because of its ability to increase brain GABA concentration, acts as an anticonvulsant on convulsive epileptic seizures and increases seizures in generalized non-convulsive epilepsy." | 3.68 | Potentiation of gamma-vinyl GABA (vigabatrin) effects by glycine. ( Depaulis, A; Liu, Z; Marescaux, C; Seiler, N; Vergnes, M, 1990) |
| " In mice, (+)-HA-966 antagonized sound and N-methyl-DL-aspartic acid (NMDLA)-induced seizures with ED50 values of 52." | 3.68 | Enantiomers of HA-966 (3-amino-1-hydroxypyrrolid-2-one) exhibit distinct central nervous system effects: (+)-HA-966 is a selective glycine/N-methyl-D-aspartate receptor antagonist, but (-)-HA-966 is a potent gamma-butyrolactone-like sedative. ( Donald, AE; Foster, AC; Hutson, PH; Iversen, LL; Iversen, SD; Kemp, JA; Leeson, PD; Marshall, GR; Oles, RJ; Singh, L, 1990) |
| "This study evaluated the potentiation by glycine of anticonvulsant drugs in maximal electroshock seizures in rats." | 3.68 | Potentiation by glycine of anticonvulsant drugs in maximal electroshock seizures in rats. ( Adams, HR; Frye, GD; Peterson, SL; Trzeciakowski, JP, 1990) |
| " Metabolic changes associated with kainic acid seizures predominate in the hippocampus, where there are decreases in aspartate (-26%), glutamate (-45%), taurine (-20%), and glutamine (-32%) concentrations and an increase in gamma-aminobutyric acid (GABA) concentration (+ 26%)." | 3.67 | Changes in regional neurotransmitter amino acid levels in rat brain during seizures induced by L-allylglycine, bicuculline, and kainic acid. ( Chapman, AG; Meldrum, BS; Premachandra, M; Westerberg, E, 1984) |
| "The anticonvulsant effect of either phenobarbital or dilantin was potentiated by exogenous glycine in DBA/2 audiogenic seizure mice and in 3-mercaptopropionic acid-induced seizures." | 3.67 | Glycine potentiates the action of some anticonvulsant drugs in some seizure models. ( Lajtha, A; Toth, E, 1984) |
| "25 mg/kg produced partial protection against 3-mercaptopropionic acid (MPA)-induced seizures." | 3.67 | Synergistic anticonvulsant effects of a GABA agonist and glycine. ( Sarhan, S; Seiler, N, 1984) |
| " The purpose of the present study was to determine whether these compounds can antagonize strychnine-induced seizures when administered intraperitoneally and to compare their effects with those of sarcosine (N-methylglycine) and glycine." | 3.67 | Prevention of strychnine-induced seizures and death by the N-methylated glycine derivatives betaine, dimethylglycine and sarcosine. ( Freed, WJ, 1985) |
| " The behavioral response to the administration of the glycine antagonist, strychnine, was also evaluated in 2- and 24-month-old animals to investigate the relevance of these parameters to the susceptibility to seizures." | 3.67 | Age-dependent changes in brain glycine concentration and strychnine-induced seizures in the rat. ( Chung, E; Hunter, C; Van Woert, MH, 1989) |
| " GSH and its related aminoacids as cysteine and glycine greatly decreased the duration of INH-induced seizures, while glutamic acid did not protect against convulsions caused by INH." | 3.67 | Anti-convulsant effects by reduced glutathione and related aminoacids in rats treated with isoniazid. ( Colombo-Zefinetti, G; Pinelli, A; Tofanetti, O; Trivulzio, S, 1988) |
| "Strychnine poisoning leads to seizures that have traditionally been attributed to competitive antagonism of glycine receptors in the spinal cord." | 3.67 | Glycine potentiates strychnine-induced convulsions: role of NMDA receptors. ( Beitz, AJ; Larson, AA, 1988) |
| ") to mice, had only a marginal protective effect against seizures induced 1 hr later by 3-mercaptopropionic acid (MPA)." | 3.67 | Amplification by glycine of the anticonvulsant effect of THPO, a GABA uptake inhibitor. ( Hjeds, H; Krogsgaard-Larsen, P; Sarhan, S; Schousboe, A; Seiler, N, 1985) |
| "Patients with nonketotic hyperglycinemia generally have intractable seizures that are poorly responsive to anticonvulsant medication." | 3.67 | The effectiveness of benzoate in the management of seizures in nonketotic hyperglycinemia. ( Kulovich, S; Nyhan, WL; Qiao, CN; Wolff, JA; Yu, AL, 1986) |
| "The ability of betaine to block homocysteine, pentylenetetrazol, and electroshock induced seizures in mice has previously been observed." | 3.67 | Effects of betaine on seizures in the rat. ( Freed, WJ; Ghoz, EH, 1985) |
| "In rabbits, generalized seizures were induced by methoxypyridoxine, and changes in amino acid concentrations of 15 brain regions were investigated before seizure onset and during the course of sustained epileptiform activity." | 3.66 | Alterations in the content of amino acid neurotransmitters before the onset and during the course of methoxypyridoxine-induced seizures in individual rabbit brain regions. ( Haug, P; Nitsch, C; Schmude, B, 1983) |
| "The preferential alpha 2-noradrenergic agonist clonidine dose-relatedly increased the onset of seizures and mortality times, and decreased severity in rats treated with D,L-allylglycine." | 3.66 | Alpha-noradrenaline modulation of D,L-allylgycine seizures. ( Ashton, D; Wauquier, A, 1981) |
| "Two female infants with nonketotic hyperglycinemia (NKH) were treated with diazepam for the control of seizures." | 3.66 | Nonketotic hyperglycinemia: treatment with diazepam--a competitor for glycine receptors. ( Hughes, JR; Matalon, R; Michals, K; Naidu, S, 1983) |
| "Strychnine poisoning results in a predictable and treatable sequence of events involving blockade of the inhibitory neurotransmitter, extensor muscle spasms, seizures, and respiratory paralysis." | 3.66 | Strychnine poisoning. Recovery from profound lactic acidosis, hyperthermia, and rhabdomyolysis. ( Boyd, RE; Brennan, PT; Deng, JF; Rochester, DF; Spyker, DA, 1983) |
| "Senegalese baboons (Papio papio), with a natural syndrome of photosensitive epilepsy, consistently show generalized myoclonic jerks if stimulated stroboscopically at hourly intervals, two to eight hours after the intravenous administration of allylglycine, 200 mg/kg." | 3.65 | A primate model for testing anticonvulsant drugs. ( Horton, RW; Meldrum, BS; Toseland, PA, 1975) |
| "Neonatal seizures, as distinguished from nonconvulsive abnormal movements, are a significant problem in neonatal intensive care units." | 2.37 | Neonatal seizures. ( Bergman, I; Crumrine, P; Painter, MJ, 1986) |
| "Classic nonketotic hyperglycinemia is caused by mutations or genomic changes in genes that encode the protein components of the glycine cleavage enzyme system." | 1.62 | Genotypic and phenotypic features in Turkish patients with classic nonketotic hyperglycinemia. ( Bayrak, H; Ceylaner, S; Kasapkara, ÇS; Kılıç, M; Küçükcongar, A; Olgaç, A; Yıldız, Y; Yüksel, D; Zenciroğlu, A, 2021) |
| "The incidence and clinical aspects of seizures remain to be elucidated in patients with acute pesticide intoxication." | 1.48 | Seizures in patients with acute pesticide intoxication, with a focus on glufosinate ammonium. ( Gil, HW; Hong, SY; Kim, DE; Park, S; Park, SY, 2018) |
| "In two chemically induced seizure models, mice with reduced Homerb/c protein had less severe seizures than control mice." | 1.42 | Down-regulation of Homer1b/c protects against chemically induced seizures through inhibition of mTOR signaling. ( Cao, L; Di, ZL; Jiang, Y; Lei, H; Tian, Y; Zhang, GJ, 2015) |
| "The encephalopathy and seizures were ascribed to accumulation of toxic metabolites of glycine, especially ammonia (serum level -1261 mcmol/L)." | 1.37 | Postprostatectomy seizures: A case report. ( Bichu, P; Misra, M; Phadke, G; Sangha, H, 2011) |
| "All GlyT1 inhibitors increased seizure thresholds dose-dependently, indicative of anticonvulsant activity." | 1.36 | Glycine transporter 1 (GlyT1) inhibitors exhibit anticonvulsant properties in the rat maximal electroshock threshold (MEST) test. ( Bradford, AM; Herdon, HJ; Kalinichev, M; Porter, RA; Starr, KR; Teague, S, 2010) |
| "In the present study seizure threshold doses of TZG were tested in the wild type and mutant mice." | 1.35 | Seizure responses and induction of Fos by the NMDA agonist (tetrazol-5-yl)glycine in a genetic model of NMDA receptor hypofunction. ( Duncan, GE; Farrington, JS; Inada, K; Koller, BH, 2008) |
| "Diazepam (DIZ) was used as anticonvulsant." | 1.35 | A substance in broad beans (Vicia faba) is protective against experimentally induced convulsions in mice. ( Mustafa, AA; Salih, MA, 2008) |
| "Coma and convulsions develop in neonates in typical GE while psychomotor retardation and behavioral abnormalities in infancy and childhood are observed in mild GE." | 1.35 | Model mice for mild-form glycine encephalopathy: behavioral and biochemical characterizations and efficacy of antagonists for the glycine binding site of N-methyl D-aspartate receptor. ( Aoki, Y; Ichinohe, A; Kamada, F; Kanno, J; Kojima-ishii, K; Komatsuzaki, S; Kure, S; Matsubara, Y; Mizoi, K; Nakahara, D; Narisawa, A; Oda, M; Shinka, T; Sugawara, T; Yokoyama, H, 2008) |
| "Postictal seizure protection (PSP) is an endogenous anticonvulsant phenomenon that follows an epileptic seizure and inhibits the induction of further seizures." | 1.34 | Lesion of the tuberomammillary nucleus E2-region attenuates postictal seizure protection in rats. ( Chen, Z; Jin, CL; Luo, JH; Wang, S; Wu, DC; Zhu, YY; Zhuge, ZB, 2007) |
| "Latrunculin A (4 microg/ml) was perfused for three consecutive days (8h a day) to promote in vivo F-actin depolymerization." | 1.34 | Changes in extracellular amino acid concentrations in the rat hippocampus after in vivo actin depolymerization with latrunculin A. ( Oreiro-García, MT; Sierra-Marcuño, G; Sierra-Paredes, G; Vázquez-Illanes, MD, 2007) |
| "Using the rat Maximal Electroshock Seizure Threshold (MEST) test, (S)-3,4-DCPG (30 mg/kg, i." | 1.34 | Evaluation of the mGlu8 receptor as a putative therapeutic target in schizophrenia. ( Harris, AJ; Honey, A; Jones, DN; Jones, GA; Kelly, FM; Kew, JN; Maycox, PR; Melarange, RA; Murdock, PR; Robbins, MJ; Rocheville, M; Rourke, C; Rupniak, T; Soffin, EM; Starr, KR; Strum, J, 2007) |
| "His glycine index was 0." | 1.34 | Neonatal nonketotic hyperglycinemia. ( Bhamkar, RP; Colaco, P, 2007) |
| "Seizures were induced by bilateral intracerebroventricular (i." | 1.33 | Neuroprotective effect of (R, S)-4-phosphonophenylglycine against neuronal damage associated with homocysteic acid-induced seizures in immature rats. ( Folbergrová, J; Haugvicová, R; Langmeier, M; Riljak, V, 2006) |
| "Cerebral focal lesions in MELAS might have a metabolic nature and several pathogenetic mechanisms might be involved in the genesis of stroke-like episodes when there is a local increased ATP demand." | 1.32 | MELAS: clinical phenotype and morphological brain abnormalities. ( Bartolomei, L; Cavallaro, T; Grauso, M; Morelli, L; Piscioli, F; Rizzuto, N; Simonati, A; Sparaco, M, 2003) |
| "Generalised clonic--tonic seizures were completely suppressed and the metabolic changes were markedly ameliorated, there being only a 1." | 1.31 | Attenuation of seizures induced by homocysteic acid in immature rats by metabotropic glutamate group II and group III receptor agonists. ( Folbergrová, J; Haugvicová, R; Mares, P, 2001) |
| "PTZ-induced seizures were inhibited by three standard anticonvulsant drugs, but not by the group III selective mGluR agonist (R,S)-4-phosphonophenylglycine (PPG)." | 1.31 | Increased seizure susceptibility in mice lacking metabotropic glutamate receptor 7. ( Burnashev, N; Bushell, TJ; Clarke, VR; Collett, VJ; Collingridge, GL; Duvoisin, RM; Flor, PJ; Gasparini, F; Hampson, DR; Klebs, K; Knoepfel, T; Kuhn, R; Portet, C; Rozov, A; Sansig, G; Schmutz, M; Schroeder, M; Shigemoto, R; van Der Putten, H; Zhang, C, 2001) |
| "Glycine is a small neutral amino acid exhibiting weak anticonvulsant activities in vivo." | 1.30 | N-(benzyloxycarbonyl)glycine esters and amides as new anticonvulsants. ( Geurts, M; Lambert, DM; Poupaert, JH; Scriba, GK, 1998) |
| "The frequency of sporadic limbic motor seizures gradually increased until seizures occurred incessantly (continuous limbic motor seizures)." | 1.30 | Anticonvulsive and neuroprotective actions of a potent agonist (DCG-IV) for group II metabotropic glutamate receptors against intraventricular kainate in the rat. ( Ishida, M; Miyamoto, M; Shinozaki, H, 1997) |
| "To test the hypothesis that prolonged seizures may affect NMDA receptor characteristics in the developing brain, a 30-min episode of generalized seizures was induced in rats at 5, 10, 15 and 25 d of age by i." | 1.30 | Selective alterations in binding kinetic parameters and allosteric regulation of N-methyl-D-aspartate receptors after prolonged seizures in the developing rat brain. ( Cortey, A; Daval, JL; Doriat, JF, 1998) |
| "Patients are affected with congenital microcephaly, psychomotor retardation, and intractable seizures." | 1.30 | Beneficial effects of L-serine and glycine in the management of seizures in 3-phosphoglycerate dehydrogenase deficiency. ( Berger, R; Blau, N; de Koning, TJ; Dorland, L; Duran, M; Gooskens, R; Jaeken, J; Poll-The, BT; Van Schaftingen, E, 1998) |
| "The anti-seizure activity of DCG-IV was fully inhibited in the presence of the group II metabotropic glutamate receptor antagonist (2S,1'S, 2'S)-2-methyl-2-(carboxycyclopropyl)glycine (MCCG; 40 nmol), while MCCG alone showed no significant inhibitory effect on seizure activity." | 1.30 | Anticonvulsant and glutamate release-inhibiting properties of the highly potent metabotropic glutamate receptor agonist (2S,2'R, 3'R)-2-(2',3'-dicarboxycyclopropyl)glycine (DCG-IV). ( Attwell, PJ; Bradford, HF; Croucher, MJ; Jane, DE; Singh Kent, N, 1998) |
| "Choline treatment did not change brain choline content, and was not associated with clinical or radiological improvement." | 1.30 | One-methyl group metabolism in non-ketotic hyperglycinaemia: mildly elevated cerebrospinal fluid homocysteine levels. ( Bottiglieri, T; Charles, HC; Gray, L; Hyland, K; Jaeken, J; Kahler, SG; Lazeyras, F; Van Hove, JL; Zeisel, SH, 1998) |
| " The pharmacokinetics of the active compounds was studied in dogs, which is a common animal model for a comparative crossover pharmacokinetic studies." | 1.30 | Pharmacokinetic analysis and anticonvulsant activity of glycine and glycinamide derivatives. ( Bialer, M; Dagan, A; Sussan, S, 1999) |
| "Furthermore, SPD 502 increased the seizure threshold for electroshock-induced tonic seizures in mice at i." | 1.30 | SPD 502: a water-soluble and in vivo long-lasting AMPA antagonist with neuroprotective activity. ( Drejer, J; Gouliaev, AH; Jensen, LH; Mathiesen, C; Moller, A; Nielsen, EO; Varming, T; Wätjen, F, 1999) |
| "Bicuculline plus cyclosporine-induced convulsions were significantly suppressed by an activation of GABAergic transmission with diazepam, phenobarbital and valproate." | 1.30 | Inhibition of GABA system involved in cyclosporine-induced convulsions. ( Fujisaki, K; Fujiwara, M; Kataoka, Y; Miura, I; Nakao, T; Oishi, R; Shuto, H; Sueyasu, M; Watanabe, Y, 1999) |
| "Seizures were induced once a day for 3 consecutive days, either from post-natal day 5 (P5) to P7 or from P15 to P17." | 1.30 | Repeated seizure-associated long-lasting changes of N-methyl-D-aspartate receptor properties in the developing rat brain. ( Daval, JL; Doriat, JF; Humbert, AC; Koziel, V, 1999) |
| "Interestingly, convulsions which were observed in the NMDA-treated rats were almost totally suppressed by bilobalide." | 1.30 | Bilobalide, a constituent of Ginkgo biloba, inhibits NMDA-induced phospholipase A2 activation and phospholipid breakdown in rat hippocampus. ( Chatterjee, SS; Hilgert, M; Klein, J; Lehr, M; Weichel, O, 1999) |
| "All animals were tested three times for seizure threshold, and were then decapitated and the brains removed for analysis of the amino acids." | 1.30 | Effects of ammonia on pentylenetetrazole-induced seizure threshold. ( Arikan, K; Coskun, T; Guvener, B; Oran, O, 1999) |
| "1." | 1.29 | Brain amino acid levels are related to seizure propensity in the gerbil (Meriones unguiculatus). ( Blumsom, NL; Gardiner, KA; Laming, PR, 1993) |
| "When studied 28 d after the last evoked seizure, we found that kindling induced a 2." | 1.29 | Kindling induces the long-lasting expression of a novel population of NMDA receptors in hippocampal region CA3. ( Bonhaus, DW; Kraus, JE; McNamara, JO; Nadler, JV; Yeh, GC, 1994) |
| "MDL 100,458 antagonized audiogenic seizures in DBA/2J mice (ED50 = 20." | 1.29 | MDL 100,458 and MDL 102,288: two potent and selective glycine receptor antagonists with different functional profiles. ( Baron, BM; Harrison, BL; Kehne, JH; McCloskey, TC; Palfreyman, MG; Poirot, M; Salituro, FG; Siegel, BW; Slone, AL; Van Giersbergen, PL, 1995) |
| "A modest increase in electrical seizure threshold was observed in mice injected with (S)-4C3HPG." | 1.29 | Modulation of seizure activity in mice by metabotropic glutamate receptor ligands. ( Dalby, NO; Thomsen, C, 1996) |
| "Cavernous angiomas are vascular malformations that cause neurodegeneration and symptoms including epileptiform seizures, headache, and motor deficits." | 1.29 | High levels of glycine and serine as a cause of the seizure symptoms of cavernous angiomas? ( Hamberger, A; Mozzi, R; Nyström, B; Rydenhag, B; van Gelder, N; von Essen, C, 1996) |
| "7CKA did not affect NMDA-induced convulsions but reduced the D-serine potentiation of NMDA responses." | 1.28 | In vitro and in vivo characterization of the NMDA receptor-linked strychnine-insensitive glycine site. ( Peeters, BW; Vanderheyden, PM, 1992) |
| "Limbic seizure-activity was induced by injecting kainic acid into the amygdala of rats." | 1.28 | Limbic seizure-induced changes in extracellular amino acid levels in the hippocampal formation: a microdialysis study of freely moving rats. ( Berg, M; Bruhn, T; Cobo, M; Diemer, NH, 1992) |
| "The glycine antagonists were potent anticonvulsants after their i." | 1.28 | Potent indole- and quinoline-containing N-methyl-D-aspartate antagonists acting at the strychnine-insensitive glycine binding site. ( Baron, BM; Harrison, BL; McDonald, IA; Meldrum, BS; Palfreyman, MG; Salituro, FG; Siegel, BW; Slone, AL; Turner, JP; White, HS, 1992) |
| "The patient developed a series of partial seizures during an 8 min period." | 1.28 | Seizure related elevations of extracellular amino acids in human focal epilepsy. ( Carlson, H; Hillered, L; Ronne-Engström, E; Ungerstedt, U, 1992) |
| "Rb1 mice were clonictonic seizure-prone, Rb2 mice were clonic seizure-prone and Rb3 mice were seizure resistant." | 1.28 | Amino acid neurotransmitter alterations in three sublines of Rb mice differing by their susceptibility to audiogenic seizures. ( Ciesielski, L; Clement, J; Mandel, P; Simler, S, 1990) |
| "This post-resection syndrome is caused by resorption of a large amount of the hypotonic solution used during the surgical procedure and containing 1." | 1.28 | [Resorption of the lavage fluid during transurethral resection of the prostate. Apropos of 13 cases]. ( Clément, P; Paulet, C, 1990) |
| "It also prevented pentylenetetrazol seizures in rats in a four times lower dose." | 1.27 | Antagonism of seizures induced by the administration of the endogenous convulsant quinolinic acid into rat brain ventricles. ( Kiseleva, IP; Lapin, IP; Prakhie, IB, 1986) |
| "1-Deprenyl alone hardly affected the seizure threshold." | 1.27 | The glycine-prodrug, milacemide, increases the seizure threshold due to hyperbaric oxygen; prevention by 1-deprenyl. ( Duvdevani, Y; Kerem, D; Youdim, MB, 1988) |
| "Strychnine induced two types of motor seizures: (1) falling over with tail whipping and (2) convulsions." | 1.27 | Prevention of the convulsant and hyperalgesic action of strychnine by intrathecal glycine and related amino acids. ( Banas, C; Beyer, C; Gomora, P; Komisaruk, BR, 1988) |
| "These levels normalized 2 h after the convulsion." | 1.27 | Measurement during convulsions of guanidino compound levels in cerebrospinal fluid collected with a catheter inserted into the cisterna magna of rabbits. ( Edamatsu, R; Fujikawa, N; Hiramatsu, M; Mori, A; Shirasu, A; Suzuki, S; Yamamoto, M, 1988) |
| "Strychnine treated rats, at all doses, vocalized consistently in response to light cutaneous stimulation; a significant proportion of glycine treated rats also vocalized, but were not as sensitive to mild stimulation." | 1.27 | Hyperalgesia induced by altered glycinergic activity at the spinal cord. ( Beyer, C; Komisaruk, BR; Roberts, LA, 1985) |
| "Diazepam, known to produce its anticonvulsant, sedative and muscle relaxant effects through its interaction either with central GABA or glycine receptors was found to be the most potent (48." | 1.27 | Effects of glycine and other inhibitory amino acid neurotransmitters on strychnine convulsive threshold in mice. ( Sangiah, S, 1985) |
| "Moreover, harmane-induced convulsions can be inhibited reversibly by diazepam in a manner which is consistent with the assumption of competitive antagonism in vivo." | 1.26 | Benzodiazepine antagonism by harmane and other beta-carbolines in vitro and in vivo. ( Borbe, HO; Fehske, KJ; Müller, WE; Nanz, C; Rommelspacher, H; Wollert, U, 1981) |
| "In mice, running, clonic and tonic convulsions and lethality were assessed following transcorneal (electroshock) current or convulsant drugs, each administered alone and after cannabidiol (CBD) pretreatment." | 1.26 | Effects of cannabidiol on behavioral seizures caused by convulsant drugs or current in mice. ( Benedito, MA; Carlini, EA; Consroe, P; Leite, JR; Mechoulam, R, 1982) |
| "Myoclonic seizures of the hindlegs are induced in mice by l- and d,l-kynurenine." | 1.26 | Kynurenines and seizures. ( Lapin, IP, 1981) |
| "Kynurenine seizures are suggested to be related to the action of kynurenine on glycine receptors in the central nervous system." | 1.26 | Antagonism of L-glycine to seizures induced by L-kynurenine, quinolinic acid and strychnine in mice. ( Lapin, IP, 1981) |
| "The antagonism of various seizure and time-related components of the convulsions resulting after IV injection of D,L-allylglycine into male Wistar rats were assessed in a standard test procedure." | 1.26 | Effects of some anti-epileptic, neuroleptic and gabaminergic drugs on convulsions induced by D,L-allylglycine. ( Ashton, D; Wauquier, A, 1979) |
| "Brief focal or generalised seizures occurred (in the absence of intermittent photic stimulation) after L-allyglycine, 150-200 mg/kg, intravenously." | 1.26 | Proconvulsant, convulsant and other actions of the D- and L-stereoisomers of allylglycine in the photosensitive baboon, Papio papio. ( Laurent, H; Meldrum, BS; Menini, C; Naquet, R; Stutzmann, JM, 1979) |
| "In mice showing sound induced seizures, clobazam, 1--4 mg/kg, i." | 1.26 | Anticonvulsant action of a 1,5-benzodiazepine, clobazam, in reflex epilepsy. ( Chapman, AG; Horton, RW; Meldrum, BS, 1978) |
| "Protection against photically induced seizures or self-sustaining myoclonic responses was seen 30 to 120 min after SC-13504, 4-8 mg/kg (when plasma levels were 1 mug/ml or greater)." | 1.26 | The relationship between the anticonvulsant properties of SC-13504 and its plasma levels, measured by polarography, in baboons with photosensitive epilepsy. ( Clifford, JM; Franklin-Smyth, W; Meldrum, BS; Smyth, MR, 1976) |
| "In mice, the ED(50) values for seizures following intraperitoneal injection were allylglycine 1." | 1.25 | Seizures induced by allylglycine, 3-mercaptopropionic acid and 4-deoxypyridoxine in mice and photosensitive baboons, and different modes of inhibition of cerebral glutamic acid decarboxylase. ( Horton, RW; Meldrum, BS, 1973) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 107 (43.15) | 18.7374 |
| 1990's | 67 (27.02) | 18.2507 |
| 2000's | 43 (17.34) | 29.6817 |
| 2010's | 26 (10.48) | 24.3611 |
| 2020's | 5 (2.02) | 2.80 |
| Authors | Studies |
|---|---|
| Geurts, M | 1 |
| Poupaert, JH | 2 |
| Scriba, GK | 1 |
| Lambert, DM | 2 |
| Naraine, AS | 1 |
| Aker, R | 1 |
| Sweeney, I | 1 |
| Kalvey, M | 1 |
| Surtel, A | 1 |
| Shanbhag, V | 1 |
| Dawson-Scully, K | 1 |
| Gonçalves, FB | 1 |
| Garcia-Gomes, MSA | 1 |
| Silva-Sampaio, AC | 1 |
| Kirsten, TB | 1 |
| Bondan, EF | 1 |
| Sandini, TM | 1 |
| Flório, JC | 1 |
| Lebrun, I | 1 |
| Coque, AC | 1 |
| Alexandre-Ribeiro, SR | 1 |
| Massironi, SMG | 1 |
| Mori, CMC | 1 |
| Bernardi, MM | 1 |
| Poothrikovil, RP | 1 |
| Al Thihli, K | 1 |
| Al Futaisi, A | 1 |
| Al Murshidi, F | 1 |
| Bas-Orth, C | 1 |
| Koch, M | 1 |
| Lau, D | 1 |
| Buchthal, B | 1 |
| Bading, H | 1 |
| Nasrallah, F | 1 |
| Ben Chehida, A | 1 |
| Kraoua, I | 1 |
| Hadj-Taieb, S | 1 |
| Sanhaji, H | 1 |
| Tebib, N | 1 |
| Feki, M | 1 |
| Kaabachi, N | 1 |
| Bayrak, H | 1 |
| Yıldız, Y | 1 |
| Olgaç, A | 1 |
| Kasapkara, ÇS | 1 |
| Küçükcongar, A | 2 |
| Zenciroğlu, A | 1 |
| Yüksel, D | 1 |
| Ceylaner, S | 1 |
| Kılıç, M | 1 |
| Park, S | 2 |
| Kim, DE | 1 |
| Park, SY | 1 |
| Gil, HW | 2 |
| Hong, SY | 2 |
| Sadek, B | 1 |
| Oz, M | 1 |
| Nurulain, SM | 1 |
| Jayaprakash, P | 1 |
| Latacz, G | 1 |
| Kieć-Kononowicz, K | 1 |
| Szymańska, E | 1 |
| Glinton, KE | 1 |
| Benke, PJ | 1 |
| Lines, MA | 1 |
| Geraghty, MT | 1 |
| Chakraborty, P | 1 |
| Al-Dirbashi, OY | 1 |
| Jiang, Y | 3 |
| Kennedy, AD | 1 |
| Grotewiel, MS | 1 |
| Sutton, VR | 1 |
| Elsea, SH | 1 |
| El-Hattab, AW | 1 |
| Bruun, TUJ | 1 |
| Sidky, S | 1 |
| Bandeira, AO | 1 |
| Debray, FG | 1 |
| Ficicioglu, C | 1 |
| Goldstein, J | 1 |
| Joost, K | 1 |
| Koeberl, DD | 1 |
| Luísa, D | 1 |
| Nassogne, MC | 1 |
| O'Sullivan, S | 1 |
| Õunap, K | 1 |
| Schulze, A | 2 |
| van Maldergem, L | 2 |
| Salomons, GS | 1 |
| Mercimek-Andrews, S | 1 |
| Oka, A | 1 |
| Iizuka, M | 1 |
| Onimaru, H | 1 |
| Izumizaki, M | 1 |
| Myhrer, T | 3 |
| Mariussen, E | 1 |
| Enger, S | 3 |
| Aas, P | 3 |
| Xiang, J | 1 |
| Ezgu, F | 1 |
| Çiftci, B | 1 |
| Topçu, B | 1 |
| Adıyaman, G | 1 |
| Gökmenoğlu, H | 1 |
| Kasapkara, Ç | 1 |
| Biberoğlu, G | 1 |
| Tümer, L | 1 |
| Hasanoğlu, A | 1 |
| Sierra-Paredes, G | 4 |
| Loureiro, AI | 1 |
| Wright, LC | 1 |
| Sierra-Marcuño, G | 4 |
| Soares-da-Silva, P | 1 |
| Cao, L | 1 |
| Tian, Y | 1 |
| Zhang, GJ | 1 |
| Lei, H | 1 |
| Di, ZL | 1 |
| Pulla, P | 1 |
| Tran, C | 1 |
| Levandovskiy, V | 1 |
| Patel, V | 1 |
| Cortez, MA | 1 |
| Royes, LF | 1 |
| Gabbi, P | 1 |
| Ribeiro, LR | 1 |
| Della-Pace, ID | 1 |
| Rodrigues, FS | 1 |
| de Oliveira Ferreira, AP | 1 |
| da Silveira Junior, ME | 1 |
| da Silva, LR | 1 |
| Grisólia, AB | 1 |
| Braga, DV | 1 |
| Dobrachinski, F | 1 |
| da Silva, AM | 1 |
| Soares, FA | 1 |
| Marchesan, S | 1 |
| Furian, AF | 1 |
| Oliveira, MS | 1 |
| Fighera, MR | 1 |
| Shakya, AK | 1 |
| Kamal, M | 1 |
| Balaramnavar, VM | 1 |
| Bardaweel, SK | 1 |
| Naik, RR | 1 |
| Saxena, AK | 1 |
| Siddiqui, HH | 1 |
| Lee, JW | 1 |
| Choi, YJ | 1 |
| Song, HY | 1 |
| Duncan, GE | 1 |
| Inada, K | 1 |
| Farrington, JS | 1 |
| Koller, BH | 1 |
| Kalinichev, M | 1 |
| Starr, KR | 2 |
| Teague, S | 1 |
| Bradford, AM | 1 |
| Porter, RA | 1 |
| Herdon, HJ | 1 |
| Meyer, S | 1 |
| Shamdeen, MG | 1 |
| Furtwängler, R | 1 |
| Gottschling, S | 1 |
| Gortner, L | 1 |
| de Freitas, RM | 1 |
| de Oliveira Silva, F | 1 |
| Saldanha, GB | 1 |
| Jordán, J | 1 |
| Fachim, HA | 1 |
| Cunha, AO | 1 |
| Pereira, AC | 1 |
| Beleboni, RO | 1 |
| Gobbo-Neto, L | 1 |
| Lopes, NP | 1 |
| Coutinho-Netto, J | 1 |
| dos Santos, WF | 1 |
| Bichu, P | 1 |
| Phadke, G | 1 |
| Sangha, H | 1 |
| Misra, M | 1 |
| Wlaź, P | 1 |
| Poleszak, E | 1 |
| Madu, AE | 1 |
| Oliver, L | 1 |
| Lecker, I | 1 |
| Wang, DS | 1 |
| Romaschin, AD | 1 |
| Peterson, M | 1 |
| Mazer, CD | 1 |
| Orser, BA | 1 |
| De Koning, TJ | 2 |
| Duran, M | 2 |
| Pineda, M | 1 |
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8 reviews available for glycine and Seizures
| Article | Year |
|---|---|
Non-ketotic hyperglycinaemia: case report and review of medical literature.
Topics: Adult; Diagnosis, Differential; Fatal Outcome; Female; Gestational Age; Glycine; Hiccup; Humans; Hyp | 2013 |
Studies of neurotransmitter actions (GABA, glycine, and convulsants).
Topics: Amino Acids; Animals; Brain; Central Nervous System; Convulsants; GABA Antagonists; gamma-Aminobutyr | 1983 |
Central actions of valproic acid in man and in experimental models of epilepsy.
Topics: 4-Aminobutyrate Transaminase; Action Potentials; Alcohol Oxidoreductases; Aldehyde Oxidoreductases; | 1981 |
Neurologic manifestations of acute porphyria.
Topics: Acute Disease; Aminolevulinic Acid; Animals; Central Nervous System; Depression; Electrophysiology; | 1982 |
New concepts on the mechanism of action of benzodiazepines.
Topics: Animals; Benzodiazepines; Cerebellum; Chlordiazepoxide; Cyclic AMP; Diazepam; gamma-Aminobutyric Aci | 1975 |
[Are there glutamatergic, anti-GABAergic or antiglycinergic components in the action mechanism of adamantamines? Study of convulsions induced by amantadine or 1-adamantylcyclopentanamine in mice].
Topics: Amantadine; Animals; Convulsants; GABA Antagonists; gamma-Aminobutyric Acid; Glutamates; Glycine; Ma | 1990 |
Drugs acting on amino acid neurotransmitters.
Topics: Acoustic Stimulation; Amino Acids; Animals; Chemical Phenomena; Chemistry; Diazepam; Electrophysiolo | 1986 |
Neonatal seizures.
Topics: Adrenoleukodystrophy; Amino Acid Metabolism, Inborn Errors; Ammonia; Anesthetics, Local; Anticonvuls | 1986 |
240 other studies available for glycine and Seizures
| Article | Year |
|---|---|
N-(benzyloxycarbonyl)glycine esters and amides as new anticonvulsants.
Topics: 3-Mercaptopropionic Acid; Amides; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electr | 1998 |
Roundup and glyphosate's impact on GABA to elicit extended proconvulsant behavior in Caenorhabditis elegans.
Topics: Animals; Caenorhabditis elegans; gamma-Aminobutyric Acid; Glycine; Glyphosate; Herbicides; Humans; S | 2022 |
Progressive tremor and motor impairment in seizure-prone mutant tremor mice are associated with neurotransmitter dysfunction.
Topics: Animals; Aspartic Acid; Corpus Striatum; Dopamine; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; | 2023 |
Nonketotic Hyperglycinemia: Two Case Reports and Review.
Topics: Agenesis of Corpus Callosum; Apnea; Brain; Brain Diseases; Electroencephalography; Fatal Outcome; Fe | 2019 |
A microRNA signature of toxic extrasynaptic N-methyl-D-aspartate (NMDA) receptor signaling.
Topics: Animals; Bicuculline; Cells, Cultured; GABA-A Receptor Antagonists; Glutamic Acid; Glycine; Hippocam | 2020 |
Non-ketotic hyperglycinaemia: a frequent, but poorly diagnosed and managed genetic disorder in Tunisia.
Topics: Apnea; Chromatography, Ion Exchange; Coma; Consanguinity; Glycine; Humans; Hyperglycinemia, Nonketot | 2021 |
Genotypic and phenotypic features in Turkish patients with classic nonketotic hyperglycinemia.
Topics: Agenesis of Corpus Callosum; Amino Acid Oxidoreductases; Female; Genotype; Glycine; Humans; Hypergly | 2021 |
Seizures in patients with acute pesticide intoxication, with a focus on glufosinate ammonium.
Topics: Adult; Aged; Aminobutyrates; Anticonvulsants; Chi-Square Distribution; Female; Glycine; Herbicides; | 2018 |
Phenylalanine derivatives with modulating effects on human α1-glycine receptors and anticonvulsant activity in strychnine-induced seizure model in male adult rats.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Gly | 2017 |
Disturbed phospholipid metabolism in serine biosynthesis defects revealed by metabolomic profiling.
Topics: Carbohydrate Metabolism, Inborn Errors; Cell Differentiation; Child; Child, Preschool; Dietary Suppl | 2018 |
Treatment outcome of creatine transporter deficiency: international retrospective cohort study.
Topics: Adolescent; Adult; Arginine; Child; Child, Preschool; Creatine; Creatinine; Female; Genotype; Glycin | 2018 |
Inhibitory Thoracic Interneurons are not Essential to Generate the Rostro-caudal Gradient of the Thoracic Inspiratory Motor Activity in Neonatal Rat.
Topics: Animals; Animals, Newborn; Brain Stem; gamma-Aminobutyric Acid; Glycine; Inhalation; Interneurons; M | 2019 |
Capacities of metabotropic glutamate modulators in counteracting soman-induced seizures in rats.
Topics: Acetylcholinesterase; Animals; Anticonvulsants; Butyrylcholinesterase; Cyclopropanes; Drug Interacti | 2013 |
Antiepileptic potential of matrine via regulation the levels of gamma-aminobutyric acid and glutamic acid in the brain.
Topics: Alkaloids; Animals; Anticonvulsants; Aspartic Acid; Brain; gamma-Aminobutyric Acid; Glutamate Decarb | 2013 |
Diagnosis of glycine encephalopathy in a pediatric patient by detection of a GLDC mutation during initial next generation DNA sequencing.
Topics: Base Sequence; DNA Mutational Analysis; Female; Genes, Recessive; Glycine; Glycine Dehydrogenase (De | 2014 |
Effects of eslicarbazepine acetate on acute and chronic latrunculin A-induced seizures and extracellular amino acid levels in the mouse hippocampus.
Topics: Acute Disease; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Bridged Bicyclo Compounds, Hete | 2014 |
Down-regulation of Homer1b/c protects against chemically induced seizures through inhibition of mTOR signaling.
Topics: Animals; Behavior, Animal; Carrier Proteins; Disease Models, Animal; Down-Regulation; Glycine; Hippo | 2015 |
Toxicology. A child-killing toxin emerges from shadows.
Topics: Adolescent; Animals; Blood Glucose; Cause of Death; Child; Child Mortality; Child, Preschool; Coma; | 2015 |
Systemic availability of guanidinoacetate affects GABAA receptor function and seizure threshold in GAMT deficient mice.
Topics: Animals; Electrocorticography; Glycine; Guanidinoacetate N-Methyltransferase; Language Development D | 2016 |
A neuronal disruption in redox homeostasis elicited by ammonia alters the glycine/glutamate (GABA) cycle and contributes to MMA-induced excitability.
Topics: Ammonia; Animals; Cerebral Cortex; Cytokines; Electroencephalography; Glutamic Acid; Glycine; Homeos | 2016 |
Design, synthesis and evaluation of benzofuran-acetamide scaffold as potential anticonvulsant agent.
Topics: 4-Aminobutyrate Transaminase; Acetamides; Animals; Anticonvulsants; Benzofurans; Binding Sites; Cere | 2016 |
Serum S100 protein could predict altered consciousness in glyphosate or glufosinate poisoning patients.
Topics: Adult; Aged; Aminobutyrates; Biomarkers; Consciousness; Glycine; Glyphosate; Humans; Logistic Models | 2017 |
Seizure responses and induction of Fos by the NMDA agonist (tetrazol-5-yl)glycine in a genetic model of NMDA receptor hypofunction.
Topics: Animals; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Resistance; Excitator | 2008 |
Glycine transporter 1 (GlyT1) inhibitors exhibit anticonvulsant properties in the rat maximal electroshock threshold (MEST) test.
Topics: Animals; Anticonvulsants; Benzamides; Electroshock; Glycine; Glycine Plasma Membrane Transport Prote | 2010 |
Modulators of metabotropic glutamate receptors microinfused into perirhinal cortex: anticonvulsant effects in rats challenged with soman.
Topics: Animals; Anticonvulsants; Benzoates; Cyclopropanes; Dose-Response Relationship, Drug; Glycine; Infus | 2010 |
A floppy neonate with respiratory failure and burst suppression EEG (case presentation).
Topics: Diagnosis, Differential; Electroencephalography; Female; Glycine; Humans; Hyperglycinemia, Nonketoti | 2010 |
Lipoic acid alters amino acid neurotransmitters content in rat hippocampus after pilocarpine-induced seizures.
Topics: Animals; Anticonvulsants; Aspartic Acid; Dialysis; Excitatory Amino Acids; gamma-Aminobutyric Acid; | 2011 |
Neurobiological activity of Parawixin 10, a novel anticonvulsant compound isolated from Parawixia bistriata spider venom (Araneidae: Araneae).
Topics: Analysis of Variance; Animals; Anticonvulsants; Ataxia; Cerebral Cortex; Chromatography, High Pressu | 2011 |
Postprostatectomy seizures: A case report.
Topics: Aged; Glycine; Humans; Hyperammonemia; Hyponatremia; Male; Prostatectomy; Renal Dialysis; Seizures | 2011 |
Differential effects of glycine on the anticonvulsant activity of D-cycloserine and L-701,324 in mice.
Topics: Animals; Anticonvulsants; Cycloserine; Electroshock; Glycine; Male; Mice; Quinolones; Receptors, Gly | 2011 |
The perirhinal cortex of rats: an intricate area for microinfusion of anticonvulsants against soman-induced seizures.
Topics: Animals; Anticonvulsants; Brain Waves; Catheters, Indwelling; Cerebral Cortex; Cyclopentanes; Cyclop | 2013 |
Tranexamic acid concentrations associated with human seizures inhibit glycine receptors.
Topics: Adult; Aged; Aged, 80 and over; Aminocaproic Acid; Animals; Anticonvulsants; Aprotinin; Binding, Com | 2012 |
Congenital microcephaly and seizures due to 3-phosphoglycerate dehydrogenase deficiency: outcome of treatment with amino acids.
Topics: Carbohydrate Dehydrogenases; Child; Child, Preschool; Female; Glycine; Humans; Infant; Male; Microce | 2002 |
Inhibition of group I metabotropic glutamate receptor responses in vivo in rats by a new generation of carboxyphenylglycine-like amino acid antagonists.
Topics: Alanine; Animals; Benzoates; Cerebellum; Dose-Response Relationship, Drug; Drug Interactions; Excita | 2002 |
Neuroprotective activity of CHF3381, a putative N-methyl-D-aspartate receptor antagonist.
Topics: Animals; Anticonvulsants; Cell Death; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glycin | 2002 |
N-, alpha-, and beta-Substituted 3-Aminopropionic acids: design, syntheses and antiseizure activities.
Topics: Animals; Anticonvulsants; Binding Sites; Electroshock; gamma-Aminobutyric Acid; Glycine; Male; Model | 2003 |
Hydantoin-substituted 4,6-dichloroindole-2-carboxylic acids as ligands with high affinity for the glycine binding site of the NMDA receptor.
Topics: Animals; Anticonvulsants; Binding Sites; Binding, Competitive; Brain; Electroshock; Female; Glycine; | 2003 |
Tricyclic indole-2-carboxylic acids: highly in vivo active and selective antagonists for the glycine binding site of the NMDA receptor.
Topics: Animals; Anticonvulsants; Binding Sites; Binding, Competitive; Brain; Brain Infarction; Crystallogra | 2003 |
Seizures induced by homocysteic acid in immature rats are prevented by group III metabotropic glutamate receptoragonist (R,S)-4-phosphonophenylglycine.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation | 2003 |
MELAS: clinical phenotype and morphological brain abnormalities.
Topics: Adenosine Triphosphatases; Adult; Alanine; Brain; Carboxylic Ester Hydrolases; Child; DNA, Mitochond | 2003 |
Glycine and sodium glucuronate in the management of convulsions due to hydrazides.
Topics: Anti-Bacterial Agents; Disease Management; Glucuronates; Glucuronic Acid; Glycine; Humans; Niacin; N | 1956 |
[ON THE EFFECT OF EXPERIMENTALLY INDUCED CONVULSIONS ON THE PERMEABILITY OF THE HEMATOENCEPHALIC BARRIER TO VARIOUS AMINO ACIDS].
Topics: Alanine; Amino Acids; Blood Chemical Analysis; Blood-Brain Barrier; Cerebrospinal Fluid; Chemical Ph | 1963 |
AMINO ACID METABOLISM IN RAT BRAIN STUDIED WITH 14C-LABELLED GLUCOSE.
Topics: Alanine; Amino Acids; Aminobutyrates; Aspartic Acid; Brain; Carbon Isotopes; Glucose; Glutamates; Gl | 1964 |
STUDIES ON THE MECHANISM OF ACTION OF AMINOOXYACETIC ACID. I. REVERSAL OF AMINOOXYACETIC ACID-INDUCED CONVULSIONS BY VARIOUS AGENTS.
Topics: Acetates; Acetone; Aldehydes; Aminooxyacetic Acid; Antidotes; Cats; Electroencephalography; Glycine; | 1964 |
Alcoholism-related phenotypes and genetic variants of the CB1 receptor.
Topics: Adult; Alanine; Alcoholism; Analysis of Variance; Case-Control Studies; Chitinases; Delirium; Drosop | 2003 |
In vivo modulation of extracellular hippocampal glutamate and GABA levels and limbic seizures by group I and II metabotropic glutamate receptor ligands.
Topics: Amino Acids; Animals; Anticonvulsants; Benzoates; Bridged Bicyclo Compounds, Heterocyclic; Cycloprop | 2004 |
Natural history of nonketotic hyperglycinemia in 65 patients.
Topics: Adolescent; Age of Onset; Agenesis of Corpus Callosum; Anticonvulsants; Apnea; Child; Child, Prescho | 2004 |
Seizures and a hiccup in the diagnosis.
Topics: Fatal Outcome; Female; Glycine; Hiccup; Humans; Infant; Seizures | 2004 |
Apoptosis-inducing factor is a key factor in neuronal cell death propagated by BAX-dependent and BAX-independent mechanisms.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Apoptosis; Apoptosis Inducing Fac | 2005 |
CoMFA, synthesis, and pharmacological evaluation of (E)-3-(2-carboxy-2-arylvinyl)-4,6-dichloro-1H-indole-2-carboxylic acids: 3-[2-(3-aminophenyl)-2-carboxyvinyl]-4,6-dichloro-1H-indole-2-carboxylic acid, a potent selective glycine-site NMDA receptor antag
Topics: Animals; Anticonvulsants; Binding Sites; Carboxylic Acids; Cyclic GMP; Glycine; In Vitro Techniques; | 2005 |
Repeated administration of group I mGluR antagonists prevents seizure-induced long-term aberrations in hippocampal synaptic plasticity.
Topics: Analysis of Variance; Animals; Benzoates; Dose-Response Relationship, Radiation; Drug Interactions; | 2005 |
Synthesis of thieno[2,3-b]pyridinones acting as cytoprotectants and as inhibitors of [3H]glycine binding to the N-methyl-D-aspartate (NMDA) receptor.
Topics: Animals; Binding, Competitive; Blood-Brain Barrier; Cell Line; Cytoprotection; Electroshock; Glycine | 2006 |
Anticonvulsant activity of hydroalcoholic extracts from Erythrina velutina and Erythrina mulungu.
Topics: Administration, Oral; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Erythrina; Glycine | 2007 |
Lesion of the tuberomammillary nucleus E2-region attenuates postictal seizure protection in rats.
Topics: Animals; Brain; Electroshock; Enzyme Inhibitors; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Hi | 2007 |
Changes in extracellular amino acid concentrations in the rat hippocampus after in vivo actin depolymerization with latrunculin A.
Topics: Actins; Animals; Bridged Bicyclo Compounds, Heterocyclic; Excitatory Amino Acids; gamma-Aminobutyric | 2007 |
Neuroprotective effect of (R, S)-4-phosphonophenylglycine against neuronal damage associated with homocysteic acid-induced seizures in immature rats.
Topics: Animals; Glycine; Hippocampus; Homocysteine; Neuroprotective Agents; Rats; Rats, Wistar; Receptors, | 2006 |
Evaluation of the mGlu8 receptor as a putative therapeutic target in schizophrenia.
Topics: Amphetamine; Animals; Anticonvulsants; Anxiety; Autoreceptors; Benzoates; Brain; Central Nervous Sys | 2007 |
Glycine uptake regulates hippocampal network activity via glycine receptor-mediated tonic inhibition.
Topics: Animals; Astrocytes; Convulsants; Data Interpretation, Statistical; Electrophysiology; Excitatory Po | 2008 |
A substance in broad beans (Vicia faba) is protective against experimentally induced convulsions in mice.
Topics: Analysis of Variance; Animals; Anticonvulsants; Chromatography, Thin Layer; Diazepam; Disease Models | 2008 |
Neonatal nonketotic hyperglycinemia.
Topics: Amino Acid Metabolism, Inborn Errors; Disease Progression; Fatal Outcome; Glycine; Humans; Hyperglyc | 2007 |
Anticonvulsant and neuroprotective effect of (S)-3,4-dicarboxyphenylglycine against seizures induced in immature rats by homocysteic acid.
Topics: Animals; Animals, Newborn; Anticonvulsants; Behavior, Animal; Benzoates; Brain; Dose-Response Relati | 2008 |
Face-washing behavior induced by the group I metabotropic glutamate receptor agonist (S)-3,5-DHPG in mice is mediated by mGlu1 receptor.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Glycine | 2008 |
Model mice for mild-form glycine encephalopathy: behavioral and biochemical characterizations and efficacy of antagonists for the glycine binding site of N-methyl D-aspartate receptor.
Topics: Aggression; Amino Acid Oxidoreductases; Animals; Anxiety; Binding Sites; Brain Diseases, Metabolic; | 2008 |
Treatment of hyperglycinemia.
Topics: Acidosis; Agranulocytosis; Amino Acid Metabolism, Inborn Errors; Blood Platelet Disorders; Child; Ch | 1967 |
Hypersarcosinemia. A newly described inborn error of metabolism.
Topics: Amino Acid Metabolism, Inborn Errors; Animals; Erythrocytes; Female; Glycine; Glyoxylates; Humans; I | 1967 |
Persistent tachycardia, paroxymal hypertension, and seizures: association with hyperglycinuria, dominantly inherited microphthalmia, and cataracts.
Topics: Adult; Amino Acid Metabolism, Inborn Errors; Amino Acids; Cataract; Female; Glycine; Humans; Hyperte | 1967 |
Benzodiazepine antagonism by harmane and other beta-carbolines in vitro and in vivo.
Topics: Alkaloids; Animals; Anti-Anxiety Agents; Benzodiazepines; Brain; Carbolines; Female; gamma-Aminobuty | 1981 |
Effects of cannabidiol on behavioral seizures caused by convulsant drugs or current in mice.
Topics: Animals; Cannabidiol; Cannabinoids; Central Nervous System; Convulsants; Electroshock; GABA Antagoni | 1982 |
Alterations in the content of amino acid neurotransmitters before the onset and during the course of methoxypyridoxine-induced seizures in individual rabbit brain regions.
Topics: Amino Acids; Animals; Aspartic Acid; Brain; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glut | 1983 |
Anticonvulsant effects of some inhibitory neurotransmitter amino acids.
Topics: Acoustic Stimulation; Amino Acids; Animals; Anticonvulsants; Electroshock; gamma-Aminobutyric Acid; | 1983 |
Changes in regional neurotransmitter amino acid levels in rat brain during seizures induced by L-allylglycine, bicuculline, and kainic acid.
Topics: Allylglycine; Amino Acids; Animals; Aspartic Acid; Bicuculline; Brain; gamma-Aminobutyric Acid; Glut | 1984 |
Kynurenines and seizures.
Topics: Animals; Anticonvulsants; Brain; Convulsants; gamma-Aminobutyric Acid; Glycine; Kynurenine; Mice; Ra | 1981 |
Alpha-noradrenaline modulation of D,L-allylgycine seizures.
Topics: Allylglycine; Animals; Clonidine; Glycine; Male; Norepinephrine; Prazosin; Rats; Rats, Inbred Strain | 1981 |
Nonketotic hyperglycinemia: treatment with diazepam--a competitor for glycine receptors.
Topics: Binding, Competitive; Choline; Diazepam; Electroencephalography; Female; Folic Acid; Glycine; Humans | 1983 |
Replacement of the peptide-backbone amides connecting Tyr-Gly and Gly-Gly in leucine-enkephalin with ketomethylene groups: synthesis and biological activity.
Topics: Analgesia; Animals; Biological Assay; Chemical Phenomena; Chemistry; Dose-Response Relationship, Dru | 1984 |
Glycine potentiates the action of some anticonvulsant drugs in some seizure models.
Topics: 3-Mercaptopropionic Acid; Acoustic Stimulation; Animals; Anticonvulsants; Disease Models, Animal; Dr | 1984 |
Synergistic anticonvulsant effects of a GABA agonist and glycine.
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Drug Synergism; gamma-Aminobutyric Acid; Glycine | 1984 |
The amplification of the anticonvulsant effect of vinyl GABA (4-aminohexenoic acid) by esters of glycine.
Topics: 3-Mercaptopropionic Acid; Alcohols; Aminocaproates; Animals; Anticonvulsants; Drug Synergism; Glycin | 1984 |
Strychnine poisoning. Recovery from profound lactic acidosis, hyperthermia, and rhabdomyolysis.
Topics: Acidosis; Adult; Body Temperature; Creatine Kinase; Female; Fever; Glycine; Humans; Hydrogen-Ion Con | 1983 |
Opiate alkaloids antagonize postsynaptic glycine and GABA responses: correlation with convulsant action.
Topics: Animals; Cells, Cultured; Dextrorphan; Enkephalin, Methionine; Enkephalins; Evoked Potentials; gamma | 1982 |
[Strychnine in non-ketotic hyperglycinemia].
Topics: Amino Acid Metabolism, Inborn Errors; Glycine; Humans; Infant; Infant, Newborn; Muscle Hypotonia; Se | 1982 |
Antagonism of L-glycine to seizures induced by L-kynurenine, quinolinic acid and strychnine in mice.
Topics: Animals; Glycine; Kynurenine; Male; Mice; Pyridines; Quinolinic Acids; Seizures; Strychnine | 1981 |
Allosteric regulation of the N-methyl-D-aspartate receptor-linked ion channel complex and effects of ethanol in ethanol-withdrawal seizure-prone and -resistant mice.
Topics: Allosteric Regulation; Animals; Cerebral Cortex; Dizocilpine Maleate; Ethanol; Genetic Predispositio | 1995 |
Excitatory amino acid neurotransmission through both NMDA and non-NMDA receptors is involved in the anticonvulsant activity of felbamate in DBA/2 mice.
Topics: Acoustic Stimulation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvuls | 1994 |
Brain amino acid levels are related to seizure propensity in the gerbil (Meriones unguiculatus).
Topics: Amino Acids; Analysis of Variance; Animals; Arginine; Aspartic Acid; Behavior, Animal; Brain; Citrul | 1993 |
A crystal-state, solution and theoretical study of the preferred conformation of linear C alpha, alpha-diphenylglycine derivatives and dipeptides with potential anticonvulsant activity.
Topics: Animals; Anticonvulsants; Crystallography, X-Ray; Dipeptides; Glycine; Models, Molecular; Protein Co | 1994 |
Anticonvulsant activities of N-benzyloxycarbonylglycine after parenteral administration.
Topics: Animals; Anticonvulsants; Binding, Competitive; Electroshock; Glycine; Infusions, Parenteral; Male; | 1994 |
Kindling induces the long-lasting expression of a novel population of NMDA receptors in hippocampal region CA3.
Topics: Animals; Base Sequence; Glycine; Hippocampus; Kindling, Neurologic; Male; Molecular Probes; Molecula | 1994 |
Selective antagonism of the anticonvulsant effects of felbamate by glycine.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electroshock; Felbamate; Glycine; Male; | 1994 |
Transmitter amino acid levels in rat brain regions after amygdala-kindling or chronic electrode implantation without kindling: evidence for a pro-kindling effect of prolonged electrode implantation.
Topics: Amino Acids; Amygdala; Animals; Aspartic Acid; Brain; Chromatography, High Pressure Liquid; Electric | 1993 |
Diazepam potentiation by glycine in pentylenetetrazol seizures is antagonized by 7-chlorokynurenic acid.
Topics: Animals; Diazepam; Drug Synergism; Glycine; Injections, Intraventricular; Kynurenic Acid; Male; Pent | 1994 |
Response to sodium benzoate treatment in non-ketotic hyperglycinaemia.
Topics: Benzoates; Benzoic Acid; Dose-Response Relationship, Drug; Female; Glycine; Humans; Infant, Newborn; | 1994 |
(S)-4-carboxy-3-hydroxyphenylglycine, an antagonist of metabotropic glutamate receptor (mGluR) 1a and an agonist of mGluR2, protects against audiogenic seizures in DBA/2 mice.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Cricetinae; Dose-Response Relationship, Drug; Glycin | 1994 |
Blindness due to non-ketotic hyperglycinemia: report of a 38-year-old, the oldest case to date.
Topics: Adult; Amino Acid Metabolism, Inborn Errors; Blindness; Female; Glycine; Humans; Ketosis; Optic Atro | 1993 |
Dextromethorphan in infantile nonketotic hyperglycinemia.
Topics: Dextromethorphan; Dextrorphan; Glycine; Humans; Infant; Ketosis; Receptors, N-Methyl-D-Aspartate; Se | 1993 |
Non-ketotic hyperglycinaemia.
Topics: Glycine; Humans; Infant, Newborn; Male; Metabolism, Inborn Errors; Seizures | 1993 |
MDL 100,458 and MDL 102,288: two potent and selective glycine receptor antagonists with different functional profiles.
Topics: Acoustic Stimulation; Animals; Animals, Newborn; Anxiety, Separation; Binding, Competitive; Brain; G | 1995 |
Modulation of seizure activity in mice by metabotropic glutamate receptor ligands.
Topics: Animals; Anticonvulsants; Benzoates; Glycine; Male; Mice; Mice, Inbred DBA; Receptors, Metabotropic | 1996 |
High levels of glycine and serine as a cause of the seizure symptoms of cavernous angiomas?
Topics: Adult; Brain Chemistry; Ethanolamine; Ethanolamines; Female; Glycine; Hemangioma, Cavernous; Humans; | 1996 |
Glycine irrigant absorption syndrome following cystoscopy.
Topics: Absorption; Aged; Cystoscopy; Female; Glycine; Humans; Hyponatremia; Mental Disorders; Seizures; Syn | 1996 |
Anticonvulsive and neuroprotective actions of a potent agonist (DCG-IV) for group II metabotropic glutamate receptors against intraventricular kainate in the rat.
Topics: Animals; Anticonvulsants; Behavior, Animal; Cyclopropanes; Dose-Response Relationship, Drug; Excitat | 1997 |
Effects of valproate on amino acid and monoamine concentrations in striatum of audiogenic seizure-prone Balb/c mice.
Topics: Acoustic Stimulation; Amino Acids; Animals; Anticonvulsants; Biogenic Monoamines; Corpus Striatum; D | 1996 |
2,3-Dihydro-6,7-dichloro-pyrido[2,3-b]pyrazine-8-oxide as selective glycine antagonist with in vivo activity.
Topics: Animals; Avoidance Learning; Binding Sites; Cyclic N-Oxides; Dizocilpine Maleate; Excitatory Amino A | 1997 |
2-substituted (2SR)-2-amino-2-((1SR,2SR)-2-carboxycycloprop-1-yl)glycines as potent and selective antagonists of group II metabotropic glutamate receptors. 2. Effects of aromatic substitution, pharmacological characterization, and bioavailability.
Topics: Amino Acids; Animals; Anticonvulsants; Biological Availability; Disease Models, Animal; Excitatory A | 1998 |
Seizures and neuronal damage induced in the rat by activation of group I metabotropic glutamate receptors with their selective agonist 3,5-dihydroxyphenylglycine.
Topics: Analysis of Variance; Animals; Cerebral Ventricles; Cycloleucine; Excitatory Amino Acid Agonists; Gl | 1998 |
Selective alterations in binding kinetic parameters and allosteric regulation of N-methyl-D-aspartate receptors after prolonged seizures in the developing rat brain.
Topics: Allosteric Regulation; Animals; Bicuculline; Binding Sites; Brain; Dizocilpine Maleate; Female; Glut | 1998 |
Long-term use of high-dose benzoate and dextromethorphan for the treatment of nonketotic hyperglycinemia.
Topics: Amino Acid Metabolism, Inborn Errors; Benzoates; Benzoic Acid; Child; Child, Preschool; Dextromethor | 1998 |
Extracellular amino acids in the rat hippocampus during picrotoxin threshold seizures in chronic microdialysis experiments.
Topics: Amino Acids; Animals; Aspartic Acid; Electroencephalography; Extracellular Space; gamma-Aminobutyric | 1998 |
Beneficial effects of L-serine and glycine in the management of seizures in 3-phosphoglycerate dehydrogenase deficiency.
Topics: Carbohydrate Dehydrogenases; Child; Child, Preschool; Drug Therapy, Combination; Electroencephalogra | 1998 |
Anticonvulsant and glutamate release-inhibiting properties of the highly potent metabotropic glutamate receptor agonist (2S,2'R, 3'R)-2-(2',3'-dicarboxycyclopropyl)glycine (DCG-IV).
Topics: Amygdala; Animals; Anticonvulsants; Aspartic Acid; Cerebral Cortex; Cyclopropanes; Glutamic Acid; Gl | 1998 |
One-methyl group metabolism in non-ketotic hyperglycinaemia: mildly elevated cerebrospinal fluid homocysteine levels.
Topics: Amino Acid Metabolism, Inborn Errors; Benzoic Acid; Brain Diseases; Choline; Coma; Female; Glycine; | 1998 |
Roles of metabotropic glutamate receptor subtypes in modulation of pentylenetetrazole-induced seizure activity in mice.
Topics: Animals; Cerebral Ventricles; Cycloleucine; Excitatory Amino Acid Antagonists; Glycine; Indans; Infu | 1998 |
Pharmacokinetic analysis and anticonvulsant activity of glycine and glycinamide derivatives.
Topics: Animals; Anticonvulsants; Ataxia; Chromatography, High Pressure Liquid; Convulsants; Cross-Over Stud | 1999 |
Selective agonists of metabotropic glutamate receptors elicit significant EEG effects when infused in the nucleus accumbens of rats.
Topics: Amino Acids, Dicarboxylic; Animals; Behavior, Animal; Electroencephalography; Excitatory Amino Acid | 1999 |
Anticonvulsant actions of LY 367385 ((+)-2-methyl-4-carboxyphenylglycine) and AIDA ((RS)-1-aminoindan-1,5-dicarboxylic acid).
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Benzoates; Dose-Response Relationship, Drug; Epileps | 1999 |
SPD 502: a water-soluble and in vivo long-lasting AMPA antagonist with neuroprotective activity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Binding, Competiti | 1999 |
(R,S)-4-phosphonophenylglycine, a potent and selective group III metabotropic glutamate receptor agonist, is anticonvulsive and neuroprotective in vivo.
Topics: Animals; Anticonvulsants; Brain; Cell Line; Cell Membrane; Colforsin; Corpus Striatum; Cyclic AMP; E | 1999 |
Inhibition of GABA system involved in cyclosporine-induced convulsions.
Topics: Animals; Anticonvulsants; Bicuculline; Binding Sites; Brain; Cells, Cultured; Cerebellum; Cyclospori | 1999 |
Repeated seizure-associated long-lasting changes of N-methyl-D-aspartate receptor properties in the developing rat brain.
Topics: Aging; Animals; Animals, Newborn; Binding Sites; Binding, Competitive; Dizocilpine Maleate; Excitato | 1999 |
Anticonvulsant activity of a metabotropic glutamate receptor 8 preferential agonist, (R,S)-4-phosphonophenylglycine.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Female; Glycine; Inferior Colliculi; Inj | 1999 |
Novel structure having antagonist actions at both the glycine site of the N-methyl-D-aspartate receptor and neuronal voltage-sensitive sodium channels: biochemical, electrophysiological, and behavioral characterization.
Topics: Animals; Anti-Anxiety Agents; Ataxia; Behavior, Animal; Binding Sites; Binding, Competitive; Cells, | 2000 |
Bilobalide, a constituent of Ginkgo biloba, inhibits NMDA-induced phospholipase A2 activation and phospholipid breakdown in rat hippocampus.
Topics: Animals; Cells, Cultured; Choline; Cyclopentanes; Diterpenes; Dose-Response Relationship, Drug; Enzy | 1999 |
Transient nonketotic hyperglycinemia in an asphyxiated patient with pyridoxine-dependent seizures.
Topics: Asphyxia Neonatorum; Brain; Electroencephalography; Glycine; Humans; Hyperglycinemia, Nonketotic; In | 2000 |
Epileptogenesis up-regulates metabotropic glutamate receptor activation of sodium-calcium exchange current in the amygdala.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amygdala; Animals; Calcium; Dose- | 2000 |
Functional consequences of reduction in NMDA receptor glycine affinity in mice carrying targeted point mutations in the glycine binding site.
Topics: Animals; Autoradiography; Behavior, Animal; Blotting, Southern; Blotting, Western; Calcium; Cerebral | 2000 |
Effects of ammonia on pentylenetetrazole-induced seizure threshold.
Topics: Ammonia; Animals; Aspartic Acid; Brain; Dose-Response Relationship, Drug; Drug Interactions; gamma-A | 1999 |
Anticonvulsant activity of two metabotropic glutamate group I antagonists selective for the mGlu5 receptor: 2-methyl-6-(phenylethynyl)-pyridine (MPEP), and (E)-6-methyl-2-styryl-pyridine (SIB 1893).
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Femal | 2000 |
Proconvulsive effects of the mitochondrial respiratory chain inhibitor--3-nitropropionic acid.
Topics: Acetylcholine; Animals; Convulsants; Drug Interactions; Electric Stimulation; Electron Transport; El | 2000 |
Effect of extracellular long-time microperfusion of high concentrations of glutamate and glycine on picrotoxin seizure thresholds in the hippocampus of freely moving rats.
Topics: Animals; Epilepsy; Excitatory Amino Acid Antagonists; Extracellular Space; GABA Antagonists; Glutami | 2001 |
Attenuation of seizures induced by homocysteic acid in immature rats by metabotropic glutamate group II and group III receptor agonists.
Topics: Animals; Animals, Newborn; Anticonvulsants; Brain; Cyclobutanes; Cyclopropanes; Dose-Response Relati | 2001 |
Anticonvulsant activity of a mGlu(4alpha) receptor selective agonist, (1S,3R,4S)-1-aminocyclopentane-1,2,4-tricarboxylic acid.
Topics: Acoustic Stimulation; Alanine; Aminobutyrates; Animals; Anticonvulsants; Behavior, Animal; Cyclopent | 2001 |
Anticonvulsant profile of valrocemide (TV1901): a new antiepileptic drug.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Dose-Respo | 2001 |
Increased seizure susceptibility in mice lacking metabotropic glutamate receptor 7.
Topics: Animals; Anticonvulsants; Bicuculline; Cerebral Cortex; Convulsants; Drug Resistance; Electroencepha | 2001 |
Synthesis and pharmacological characterisation of a conformationally restrained series of indole-2-carboxylates as in vivo potent glycine antagonists.
Topics: Animals; Binding Sites; Glycine; Indoles; Male; Mice; Neuroprotective Agents; Rats; Rats, Sprague-Da | 2001 |
Effect of sodium dimercaptopropanesulfonate on antagonism of tetramethylenedisulphotetramine to GABA receptor.
Topics: Animals; Antidotes; Brain; Bridged-Ring Compounds; Drug Interactions; Female; GABA Antagonists; Glyc | 2001 |
Transgenic expression of a mutant glycine receptor decreases alcohol sensitivity of mice.
Topics: Animals; Behavior, Animal; Body Temperature; Central Nervous System Depressants; DNA Primers; Ethano | 2002 |
Metabotropic glutamate receptors in the hippocampus and nucleus accumbens are involved in generating seizure-induced hippocampal gamma waves and behavioral hyperactivity.
Topics: Animals; Behavior, Animal; Benzoates; Electroencephalography; Electrophysiology; Excitatory Amino Ac | 2002 |
The role of 2-keto-4-pentenoic acid in seizures induced by allylglycine.
Topics: Animals; Brain; Glutamate Decarboxylase; Glycine; Hydrogen-Ion Concentration; Keto Acids; Kinetics; | 1978 |
An experimental model to investigate disinhibitory mechanisms in penicillin epileptogenesis.
Topics: Animals; beta-Alanine; Cats; gamma-Aminobutyric Acid; Glycine; Homocysteine; Iontophoresis; Neurotra | 1978 |
A synthetic non-benzodiazepine ligand for benzodiazepine receptors: a probe for investigating neuronal substrates of anxiety.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Benzodiazepines; Body Temperature; Conflict, Psychological; g | 1979 |
Effects of some anti-epileptic, neuroleptic and gabaminergic drugs on convulsions induced by D,L-allylglycine.
Topics: Allylglycine; Animals; Anticonvulsants; Antipsychotic Agents; gamma-Aminobutyric Acid; Glycine; Male | 1979 |
Seizure proneness and neurotransmitter uptake.
Topics: Animals; Biological Transport; Choline; Dopamine; gamma-Aminobutyric Acid; Glutamates; Glycine; Mese | 1979 |
Proconvulsant, convulsant and other actions of the D- and L-stereoisomers of allylglycine in the photosensitive baboon, Papio papio.
Topics: Allylglycine; Animals; Brain; Glycine; Haplorhini; Injections, Intravenous; Injections, Intraventric | 1979 |
Anticonvulsant action of a 1,5-benzodiazepine, clobazam, in reflex epilepsy.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Benzodiazepinones; Disease Models, Animal; Drug Eval | 1978 |
Antagonism of the enhanced susceptibility to audiogenic seizures during alcohol withdrawal in the rat by gamma-aminobutyric acid (GABA) and "GABA-mimetic" agents.
Topics: 4-Aminobutyrate Transaminase; Acoustic Stimulation; Alcoholism; Aminobutyrates; Animals; Binding, Co | 1979 |
A primate model for testing anticonvulsant drugs.
Topics: Allyl Compounds; Animals; Anticonvulsants; Carbamazepine; Chromatography, Gas; Diazepam; Disease Mod | 1975 |
Effects of alterations in the metabolism of gamma-aminobutyrate on convulsant potencies.
Topics: 3-Mercaptopropionic Acid; Aminobutyrates; Aminooxyacetic Acid; Animals; Bicuculline; Diacetyl; Drug | 1977 |
Effects of taurine, glycine and GABA on convulsions produced by strychnine in the rabbit.
Topics: Animals; Electroencephalography; gamma-Aminobutyric Acid; Glycine; Male; Rabbits; Seizures; Strychni | 1979 |
[Role of uridine and pathogenesis of epileptic seizures].
Topics: Animals; Brain; gamma-Aminobutyric Acid; Glycine; Rats; Seizures; Uracil Nucleotides; Uridine Monoph | 1979 |
A comparison of the effects of allylglycine and 2-keto-4-pentenoic acid on cerebral glutamic acid decarboxylase activity and convulsions in mice [proceedings].
Topics: Animals; Brain; Carboxy-Lyases; Glutamate Decarboxylase; Glycine; Keto Acids; Mice; Pentanoic Acids; | 1977 |
Additional studies on the importance of glycine and GABA in mediating the actions of benzodiazepines.
Topics: Aminobutyrates; Animals; Bicuculline; Diazepam; Dose-Response Relationship, Drug; gamma-Aminobutyric | 1977 |
The prolonged anticonvulsant action of taurine on genetically determined seizure-susceptibility.
Topics: Acoustic Stimulation; Aminoisobutyric Acids; Animals; Electroshock; gamma-Aminobutyric Acid; Genicul | 1978 |
Regional changes in cerebral GABA concentration and convulsions produced by D and by L-allylglycine.
Topics: Aminobutyrates; Animals; Brain; Female; gamma-Aminobutyric Acid; Glycine; Rats; Seizures; Stereoisom | 1978 |
The relationship between the anticonvulsant properties of SC-13504 and its plasma levels, measured by polarography, in baboons with photosensitive epilepsy.
Topics: Animals; Anticonvulsants; Benzhydryl Compounds; Electroencephalography; Female; Glycine; Haplorhini; | 1976 |
D-and L-stereoisomers of allylglycine: convulsive action and inhibition of brain L-glutamate decarboxylase.
Topics: Animals; Blood-Brain Barrier; Brain; Carboxy-Lyases; Dose-Response Relationship, Drug; Glutamate Dec | 1977 |
Convulsions induced by hyperbaric oxygen: inhibition by phenobarbital, diazepam and baclofen.
Topics: Aminobutyrates; Animals; Baclofen; Diazepam; Female; gamma-Aminobutyric Acid; Glycine; Hyperbaric Ox | 1977 |
Brain and blood levels of allylglycine in mice following doses sufficient to inhibit glutamate decarboxylase.
Topics: Allyl Compounds; Animals; Brain; Carboxy-Lyases; Dose-Response Relationship, Drug; Female; Glutamate | 1977 |
Effects of the Areca nut constituents arecaidine and guvacine on the action of GABA in the cat central nervous system.
Topics: Action Potentials; Alanine; Aminobutyrates; Animals; Areca; Arecoline; Bicuculline; Cats; Cerebellum | 1977 |
Preconvulsive changes in brain glucose metabolism following drugs inhibiting glutamate decarboxylase.
Topics: Animals; Blood Glucose; Body Temperature; Brain; Carboxy-Lyases; Glucose; Glutamate Decarboxylase; G | 1976 |
Changes in glycogen phosphorylase activity and glycogen levels of mouse cerebral cortex during convulsions induced by homocysteine.
Topics: Animals; Cerebral Cortex; Female; Glycine; Glycogen; Homocysteine; Mice; Mice, Inbred Strains; Pheno | 1975 |
Possible role of gangliosides in epilepsy: effects of epileptic seizures on cerebral gangliosides.
Topics: Allyl Compounds; Animals; Brain; Gangliosides; Glycine; Male; Pentylenetetrazole; Rats; Seizures | 1975 |
Benzodiazepines and central glycine receptors.
Topics: Action Potentials; Animals; Bicuculline; Cats; Chlordiazepoxide; Diazepam; Glycine; Mice; Receptors, | 1976 |
A glycine antagonist reduces ischemia-induced CA1 cell loss in vivo.
Topics: Animals; Glycine; Hippocampus; Injections, Intraventricular; Ischemic Attack, Transient; Kynurenic A | 1992 |
In vitro and in vivo characterization of the NMDA receptor-linked strychnine-insensitive glycine site.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Dizocilpine Maleate; Glycine; Kynurenic Acid | 1992 |
Limbic seizure-induced changes in extracellular amino acid levels in the hippocampal formation: a microdialysis study of freely moving rats.
Topics: Amino Acids; Amygdala; Animals; Aspartic Acid; Brain Mapping; Chromatography, High Pressure Liquid; | 1992 |
Potent indole- and quinoline-containing N-methyl-D-aspartate antagonists acting at the strychnine-insensitive glycine binding site.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Binding Sites; Brain; Calcium; Glycine; Indoles; Mal | 1992 |
Seizure related elevations of extracellular amino acids in human focal epilepsy.
Topics: Amino Acids; Asparagine; Aspartic Acid; Cerebral Cortex; Dialysis; Electroencephalography; Epilepsie | 1992 |
3-(2-Carboxyindol-3-yl)propionic acid-based antagonists of the N-methyl-D-aspartic acid receptor associated glycine binding site.
Topics: Animals; Binding Sites; Cerebral Cortex; Glycine; Hippocampus; Indoles; Mice; Mice, Inbred DBA; Prop | 1992 |
Does glycine antagonism underlie the excitatory effects of methohexitone and propofol?
Topics: Anesthesia, General; Animals; Bicuculline; Central Nervous System; Electroencephalography; Ethanol; | 1992 |
The influence of strychnine-insensitive glycine receptor agonists and antagonists on generalized seizure thresholds.
Topics: Alanine; Amygdala; Animals; Glycine; Kindling, Neurologic; Kynurenic Acid; Male; Pyrrolidinones; Rat | 1991 |
Anticonvulsant drug potentiation by glycine in maximal electroshock seizures is mimicked by D-serine and antagonized by 7-chlorokynurenic acid.
Topics: Animals; Anticonvulsants; Carbamazepine; Drug Synergism; Electroshock; Glycine; Kynurenic Acid; Male | 1991 |
Abnormal endogenous amino acid release in brain slices from vitamin B-6 restricted neonatal rats.
Topics: Amino Acids; Animals; Animals, Newborn; Brain Chemistry; Chromatography, High Pressure Liquid; Elect | 1991 |
Extracellular concentrations of amino acid transmitters in ventral hippocampus during and after the development of kindling.
Topics: Amino Acids; Animals; Chromatography, High Pressure Liquid; Dialysis; Electric Stimulation; Glutamat | 1991 |
D,L-(tetrazol-5-yl) glycine: a novel and highly potent NMDA receptor agonist.
Topics: Animals; Binding, Competitive; Cerebral Cortex; Glutamates; Glutamic Acid; Glycine; Kinetics; Male; | 1991 |
Amino acid neurotransmitter alterations in three sublines of Rb mice differing by their susceptibility to audiogenic seizures.
Topics: Acoustic Stimulation; Amino Acids; Animals; Aspartic Acid; Brain; gamma-Aminobutyric Acid; Glutamate | 1990 |
Glycine potentiation of anticonvulsant drugs in pentylenetetrazol seizures in rats.
Topics: Animals; Anticonvulsants; Drug Synergism; Glycine; Male; Pentylenetetrazole; Rats; Rats, Inbred Stra | 1991 |
Kainic acid induced epileptogenesis in developing normal & undernourished rats--a computerised EEG analysis.
Topics: Age Factors; Animals; Cerebellum; Electroencephalography; Glycine; Hippocampus; Kainic Acid; Nutriti | 1990 |
Potentiation of gamma-vinyl GABA (vigabatrin) effects by glycine.
Topics: 3-Mercaptopropionic Acid; Acoustic Stimulation; Aminocaproates; Animals; Anticonvulsants; Drug Syner | 1990 |
NMDA receptors in mice bred to be prone or resistant to ethanol withdrawal seizures.
Topics: Animals; Brain; Cerebral Cortex; Dizocilpine Maleate; Drug Resistance; Ethanol; Glycine; Hippocampus | 1990 |
Enantiomers of HA-966 (3-amino-1-hydroxypyrrolid-2-one) exhibit distinct central nervous system effects: (+)-HA-966 is a selective glycine/N-methyl-D-aspartate receptor antagonist, but (-)-HA-966 is a potent gamma-butyrolactone-like sedative.
Topics: 4-Butyrolactone; Acoustic Stimulation; Animals; Aspartic Acid; Cerebral Cortex; Corpus Striatum; Dop | 1990 |
Selective blockade of N-methyl-D-aspartate (NMDA)-induced convulsions by NMDA antagonists and putative glycine antagonists: relationship with phencyclidine-like behavioral effects.
Topics: Animals; Aspartic Acid; Dose-Response Relationship, Drug; Glycine; Kainic Acid; Kynurenic Acid; Male | 1990 |
Nonketotic hyperglycinemia: pathophysiological role of NMDA-type excitatory amino acid receptors.
Topics: Glycine; Humans; Metabolic Diseases; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; S | 1990 |
Evidence for a role of glycine in area tempestas for triggering convulsive seizures.
Topics: Animals; Anticonvulsants; Bicuculline; Carbachol; Cerebral Cortex; Glycine; Kainic Acid; Kynurenic A | 1990 |
The changes in guanidino compounds in the brain of amygdala kindled seizure--comparisons with electric convulsive shock seizure.
Topics: Amygdala; Animals; Electroencephalography; Electroshock; Evoked Potentials; Glycine; Guanidines; Hip | 1990 |
[Resorption of the lavage fluid during transurethral resection of the prostate. Apropos of 13 cases].
Topics: Absorption; Diplopia; Glycine; Humans; Hypotonic Solutions; Male; Nausea; Osmolar Concentration; Pro | 1990 |
Potentiation by glycine of anticonvulsant drugs in maximal electroshock seizures in rats.
Topics: Animals; Anticonvulsants; Brain Chemistry; Carbamazepine; Chromatography, High Pressure Liquid; Diaz | 1990 |
High urinary excretion of N-(pyrrole-2-carboxyl) glycine in type II hyperprolinemia.
Topics: Amino Acid Metabolism, Inborn Errors; Consanguinity; Electroencephalography; Glycine; Growth Disorde | 1990 |
Pontine myelinolysis and delayed encephalopathy following the rapid correction of acute hyponatremia.
Topics: Aged; Brain; Glycine; Humans; Hyponatremia; Magnetic Resonance Imaging; Male; Myelin Sheath; Pons; P | 1989 |
N-methyl-D-aspartate receptor plasticity in kindling: quantitative and qualitative alterations in the N-methyl-D-aspartate receptor-channel complex.
Topics: Animals; Convulsants; Electric Stimulation; Glycine; Hippocampus; Illicit Drugs; Ion Channels; Kindl | 1989 |
A potent antagonist of the strychnine insensitive glycine receptor has anticonvulsant properties.
Topics: Animals; Anticonvulsants; Aspartic Acid; Cerebral Cortex; Cortical Spreading Depression; Female; gam | 1989 |
Regional changes in the concentrations of glutamate, glycine, taurine, and GABA in the vitamin B-6 deficient developing rat brain: association with neonatal seizures.
Topics: Amino Acids; Animals; Animals, Newborn; Brain; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic | 1989 |
Prevention of strychnine-induced seizures and death by the N-methylated glycine derivatives betaine, dimethylglycine and sarcosine.
Topics: Animals; Anticonvulsants; Betaine; Female; Glycine; Mice; Sarcosine; Seizures; Strychnine | 1985 |
Age-dependent changes in brain glycine concentration and strychnine-induced seizures in the rat.
Topics: Aging; Animals; Glycine; Medulla Oblongata; Rats; Rats, Inbred F344; Seizures; Spinal Cord; Strychni | 1989 |
Systemically administered glycine protects against strychnine convulsions, but not the behavioural effects of high pressure, in mice.
Topics: Animals; Atmospheric Pressure; Bicuculline; Dose-Response Relationship, Drug; Glycine; High Pressure | 1989 |
A response to "Effects of glycine and other inhibitor amino acid neurotransmitters on strychnine convusive threshold in mice".
Topics: Animals; Dogs; Glycine; Mice; Neurotransmitter Agents; Seizures; Strychnine | 1985 |
Anti-convulsant effects by reduced glutathione and related aminoacids in rats treated with isoniazid.
Topics: Animals; Brain Chemistry; Cysteine; Drug Interactions; gamma-Aminobutyric Acid; Glutamates; Glutamic | 1988 |
Glycine potentiates strychnine-induced convulsions: role of NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Drug Synergism; Glycine; Injections, Spinal; Mi | 1988 |
Amplification by glycine of the anticonvulsant effect of THPO, a GABA uptake inhibitor.
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Brain Chemistry; Drug Synergism; gamma-Aminobuty | 1985 |
Antagonism of seizures induced by the administration of the endogenous convulsant quinolinic acid into rat brain ventricles.
Topics: Animals; Anticonvulsants; Diazepam; gamma-Aminobutyric Acid; Glycine; Injections, Intraventricular; | 1986 |
Electroencephalographic study of SR 95103, a GABAA antagonist: interaction with inhibitory amino acids and muscimol.
Topics: Animals; Drug Interactions; Electroencephalography; gamma-Aminobutyric Acid; Glycine; Male; Muscimol | 1985 |
[Effects of GABA-ergic and glycinergic agents on pentamethylenetetrazole-induced convulsions in rats submitted to repeated injections of reserpine].
Topics: Animals; gamma-Aminobutyric Acid; Glycine; Linoleic Acids; Male; Pentylenetetrazole; Psychotropic Dr | 1986 |
[Synergic effect of GABA and glycine in the antagonism of convulsions caused by pentetrazole in rats. Study of glycine valproamide].
Topics: Animals; Drug Synergism; gamma-Aminobutyric Acid; Glycine; Male; Pentylenetetrazole; Rats; Rats, Inb | 1986 |
The glycine-prodrug, milacemide, increases the seizure threshold due to hyperbaric oxygen; prevention by 1-deprenyl.
Topics: Acetamides; Animals; Anticonvulsants; Electroencephalography; Glycine; Hyperbaric Oxygenation; Injec | 1988 |
In vivo brain dialysis of amino acids and simultaneous EEG measurements following intrahippocampal quinolinic acid injection: evidence for a dissociation between neurochemical changes and seizures.
Topics: Amino Acids; Animals; Aspartic Acid; Brain; Dialysis; Electroencephalography; gamma-Aminobutyric Aci | 1985 |
[Convulsions in mice after administration of a new aminolactone (FK-3)].
Topics: Animals; Drug Antagonism; gamma-Aminobutyric Acid; Glycine; Lactones; Male; Mice; Mice, Inbred Strai | 1988 |
Prevention of the convulsant and hyperalgesic action of strychnine by intrathecal glycine and related amino acids.
Topics: Alanine; Amino Acids; Animals; Betaine; Glycine; Injections, Spinal; Pain; Rats; Rats, Inbred Strain | 1988 |
Measurement during convulsions of guanidino compound levels in cerebrospinal fluid collected with a catheter inserted into the cisterna magna of rabbits.
Topics: Animals; Arginine; Cisterna Magna; Creatinine; Glycine; Guanidines; Male; Pentylenetetrazole; Rabbit | 1988 |
Glycine potentiates diazepam anticonvulsant activity in electroshock seizures of rats: possible sites of interaction in the brainstem.
Topics: Administration, Oral; Animals; Anticonvulsants; Diazepam; Drug Therapy, Combination; Electroshock; G | 1987 |
The effectiveness of benzoate in the management of seizures in nonketotic hyperglycinemia.
Topics: Amino Acid Metabolism, Inborn Errors; Benzoates; Benzoic Acid; Female; Glycine; Humans; Infant, Newb | 1986 |
Effects of allylglycine on photosensitivity in the lateral geniculate-kindled cat.
Topics: Allylglycine; Amygdala; Animals; Cats; Electric Stimulation; Female; Geniculate Bodies; Glycine; Kin | 1986 |
Hyperalgesia induced by altered glycinergic activity at the spinal cord.
Topics: Animals; Behavior, Animal; Castration; Female; Glycine; Hyperalgesia; Hyperesthesia; Injections, Spi | 1985 |
Effects of glycine and other inhibitory amino acid neurotransmitters on strychnine convulsive threshold in mice.
Topics: Alanine; Animals; beta-Alanine; Diazepam; Dose-Response Relationship, Drug; Glycine; Male; Mice; Mic | 1985 |
Effects of betaine on seizures in the rat.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Betaine; Glycine; Injections, Intraperitoneal; Injec | 1985 |
Proceedings: The effect of certain drugs on central synapses.
Topics: Acetylcholine; Alanine Transaminase; Allyl Compounds; Aminobutyrates; Animals; Aspartate Aminotransf | 1973 |
Possible role of cerebral amino acids in acute neurotoxic effects of DDT in mice.
Topics: Amino Acids; Animals; Behavior, Animal; Brain; Brain Chemistry; DDT; gamma-Aminobutyric Acid; Glycin | 1974 |
Proceedings: Anticonvulsive action of homotaurine and taurine.
Topics: Animals; Anticonvulsants; Cats; Electroencephalography; gamma-Aminobutyric Acid; Glycine; Hyperbaric | 1974 |
Seizures induced by allylglycine, 3-mercaptopropionic acid and 4-deoxypyridoxine in mice and photosensitive baboons, and different modes of inhibition of cerebral glutamic acid decarboxylase.
Topics: Allyl Compounds; Animals; Brain; Carboxy-Lyases; Electroencephalography; Glutamates; Glycine; Haplor | 1973 |
Proceedings: Presynaptic inhibition and the depressant actions of GABA and glycine in the feline cuneate nucleus: changes related to electrographic seizure activity.
Topics: Alkaloids; Aminobutyrates; Animals; Cats; Dioxoles; Electroencephalography; Glycine; Injections, Int | 1973 |
On the neurotoxic effects induced by alkylating agents.
Topics: Alanine; Animals; Anti-Bacterial Agents; Antimetabolites; Azaserine; Behavior, Animal; Central Nervo | 1966 |
Amino acids and cerebral excitability.
Topics: Amino Acids; Ammonia; Animals; Brain; Central Nervous System Stimulants; Diet; Glutamates; Glutamine | 1969 |
[Effect of glycine on trace afterdischarges and epileptogenic focal activity in the rabbit hippocampus].
Topics: Animals; Electroencephalography; Female; Glycine; Hippocampus; Male; Penicillins; Rabbits; Seizures | 1974 |
Epileptic brain damage in adolescent baboons following seizures induced by allylgycine.
Topics: Acid-Base Equilibrium; Allyl Compounds; Animals; Carbon Dioxide; Female; Gliosis; Glucose; Glycine; | 1974 |
[Mechanism of convulsive action of folic acid (pteroyl-glutamate) and calcium folinate in the rabbit. 2-Action of atropine and glycine].
Topics: Animals; Atropine; Brain; Calcium; Cerebral Ventricles; Folic Acid; Glycine; Injections; Injections, | 1974 |
Molecular basis of insulin action: contributions of chemical modifications and synthetic approaches.
Topics: Acetates; Acylation; Adipose Tissue; Alkylation; Animals; Arginine; Cattle; Glycine; Hypoglycemia; I | 1972 |
[Amino acid metabolism pathology in the convulsive syndrome in young children].
Topics: Alanine; Amino Acids; Arginine; Asparagine; Child, Preschool; Cystine; Female; Glutamates; Glutamine | 1972 |
The trifluoroacetylation of insulin.
Topics: Amino Acids; Animals; Biological Assay; Cattle; Chemical Phenomena; Chemistry; Chromatography, Gel; | 1973 |
Iminoglycinuria in a child in Czechoslovakia.
Topics: Amino Acid Metabolism, Inborn Errors; Cerebrospinal Fluid Proteins; Deafness; Female; Glycine; Human | 1973 |
Clinical finding and therapeutic problems in non-ketotic hyperglycinemia.
Topics: Amino Acid Metabolism, Inborn Errors; Carbon Radioisotopes; Diet Therapy; Glycine; Humans; Hypotensi | 1973 |
Corneal opacity, microphthalmia, mental retardation, microcephaly and generalized muscular spasticity associated with hyperglycinemia.
Topics: Alkaline Phosphatase; Calcium; Cerebral Palsy; Chromosomes; Consanguinity; Corneal Opacity; Female; | 1974 |
Actions of GABA, picrotoxin and bicuculline on adrenal medulla.
Topics: Acetylcholine; Adrenal Glands; Adrenal Medulla; Alkaloids; Aminobutyrates; Animals; Calcium; Catecho | 1974 |
-cyanoamino acids and related nitriles as inhibitors of glutamate decarboxylase.
Topics: Acetates; Amino Acids; Aminobutyrates; Animals; Carbon Isotopes; Carboxy-Lyases; Chickens; Cyanides; | 1971 |
Convulsive action of penicillin.
Topics: Alkaloids; Aminobutyrates; Animals; Cats; Cerebral Cortex; Glycine; Interneurons; Isoquinolines; Neu | 1972 |
The toxicity of monosodium glutamate in young rats.
Topics: Age Factors; Animals; Aspartic Acid; Brain Chemistry; Glutamates; Glutamine; Glycine; Injections, In | 1971 |
Pyridoxine deficiency and brain amino acids.
Topics: Acetates; Alanine; Amino Acids; Aminobutyrates; Animals; Brain; Brain Chemistry; Diet; Glutamates; G | 1969 |
Homocysteine-induced convulsions in the rat: protection by homoserine, serine, betaine, glycine and glucose.
Topics: Animals; Betaine; Glucose; Glycine; Homocysteine; Male; Rats; Seizures; Serine; Time Factors | 1969 |
Inhibition of Mauthner cells by allylglycine.
Topics: Animals; Cyprinidae; Glutamates; Glycine; Iontophoresis; Seizures | 1970 |
Evidence for separate systems for the transport of neutral and basic amino acids across the blood-brain barrier.
Topics: Alanine; Amino Acids; Animals; Arginine; Biological Transport; Blood-Brain Barrier; Carbon Isotopes; | 1971 |
The clinical findings in a patient with nonketotic hyperglycinemia.
Topics: Amino Acid Metabolism, Inborn Errors; Diet Therapy; Glycine; Glycine max; Humans; Infant; Infant, Ne | 1968 |
[Glycinosis (hyperglycinemia)].
Topics: Acidosis; Amino Acid Metabolism, Inborn Errors; Amino Acids; Child Development; Child, Preschool; Ch | 1968 |
Glutamic acid decarboxylase inhibition and ultrastructural changes by the convulsant drug allylglycine.
Topics: Alanine Transaminase; Alkenes; Amino Acids; Aminobutyrates; Animals; Aspartate Aminotransferases; Ca | 1969 |