glycine has been researched along with Respiratory Distress Syndrome in 59 studies
Respiratory Distress Syndrome: A syndrome characterized by progressive life-threatening RESPIRATORY INSUFFICIENCY in the absence of known LUNG DISEASES, usually following a systemic insult such as surgery or major TRAUMA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This article summarizes the effects of sivelestat on acute lung injury/acute respiratory distress syndrome (ALI/ARDS) or ARDS with coagulopathy, both of which are frequently seen in patients with COVID-19." | 9.05 | Neutrophil elastase inhibitor (sivelestat) may be a promising therapeutic option for management of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19. ( Avan, R; Bagheri, M; Habtemariam, S; Khataminia, M; Rezai Ghaleno, H; Sadremomtaz, A; Safdari, M; Saghafi, F; Sahebnasagh, A; Talaei, Z, 2020) |
| "To investigate the effect of sivelestat sodium on the prognosis in patients with acute lung injury (ALI) and acute respiratory distress syndrome (ARDS)." | 8.91 | [Effect of sivelestat sodium on the prognosis of patients with acute lung injury and acute respiratory distress syndrome: a meta-analysis]. ( Shang, Y; Sun, Z; Xia, H; Yang, Y; Yao, S, 2015) |
| "We conducted a systematic review and meta-analysis of randomized controlled trials on sivelestat for the treatment of acute lung injury and acute respiratory distress syndrome." | 8.86 | Effect of neutrophil elastase inhibitor (sivelestat sodium) in the treatment of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS): a systematic review and meta-analysis. ( Doi, A; Gremillion, DH; Igarashi, W; Iwata, K; Oba, Y; Ohji, G; Oka, H; Shimada, T; Takimoto, K, 2010) |
| "To compare the protective effect of Xuebijing injection versus Sivelestat sodium on acute lung injury/acute respiratory distress syndrome (ALI/ARDS) rats." | 8.12 | [Comparative study of the protective effect of Xuebijing injection and Sivelestat sodium on acute lung injury/acute respiratory distress syndrome rats]. ( Dong, T; Tian, W, 2022) |
| "The efficacy of sivelestat, a neutrophil elastase inhibitor, for acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) remains controversial." | 7.85 | Efficacy of early sivelestat administration on acute lung injury and acute respiratory distress syndrome. ( Asakawa, T; Fujino, Y; Kido, T; Kubo, T; Matsuda, S; Mayumi, T; Mukae, H; Muramatsu, K; Otsubo, H; Yatera, K, 2017) |
| "A multicenter retrospective survey of patients poisoned by herbicides containing glyphosate salts in Japan was conducted to identify differences in symptoms and outcome of poisoning." | 7.83 | A multicenter retrospective survey of poisoning after ingestion of herbicides containing glyphosate potassium salt or other glyphosate salts in Japan. ( Kamijo, Y; Sakamoto, T; Takai, M, 2016) |
| "The efficacy of sivelestat in the treatment of acute lung injury/acute respiratory distress syndrome (ALI/ARDS) has not been established." | 7.78 | Clinical evaluation of sivelestat for acute lung injury/acute respiratory distress syndrome following surgery for abdominal sepsis. ( Mii, S; Nakazato, K; Sakamoto, A; Takeda, S; Tanaka, K; Tsuboko, Y; Uchida, E, 2012) |
| "We experienced a case of good response in acute respiratory distress syndrome (ARDS) treated with sivelestat sodium hydrate during chemotherapy for cholangiocarcinoma." | 7.74 | [Good response in ARDS treated with sivelestat sodium hydrate during chemotherapy for cholangiocarcinoma]. ( Hanada, N; Hori, K; Kusano, S; Momi, H, 2007) |
| "We have examined the effect of DL-propargylglycine, a cystathionine gamma-lyase inhibitor, on the synthesis of CC chemokine monocyte chemotactic protein 1, Regulated upon Activation, Normal T-cell Expressed, and Secreted, and macrophage inflammatory protein-1alpha (MIP-1alpha), and CXC chemokine MIP-2 in an in vitro and in vivo model of cerulein-induced acute pancreatitis and associated lung injury." | 7.74 | Inhibition of hydrogen sulfide synthesis attenuates chemokine production and protects mice against acute pancreatitis and associated lung injury. ( Bhatia, M; Moore, PK; Tamizhselvi, R, 2008) |
| "We assessed the effects of a neutrophil elastase inhibitor, sivelestat, on respiratory and organ functions as well as on the mortality of patients with acute respiratory distress syndrome (ARDS) associated with systemic inflammatory response syndrome (SIRS)." | 7.73 | Clinical effects of a neutrophil elastase inhibitor, sivelestat, in patients with acute respiratory distress syndrome. ( Imabayashi, T; Kakihana, Y; Kanmura, Y; Matsunaga, A; Okayama, N; Omae, T; Setoguchi, D, 2006) |
| "To conduct a cost-minimisation analysis of sivelestat sodium hydrate treatment for patients in the intensive care unit (ICU) with acute lung injury (ALI) associated with systemic inflammatory response syndrome (SIRS) caused by infection." | 7.73 | Cost-minimisation analysis of sivelestat for acute lung injury associated with systemic inflammatory response syndrome. ( Abiru, T; Aikawa, N; Fujishima, S; Kobayashi, M; Matsuoka, S, 2005) |
| " He was diagnosed as having acute respiratory distress syndrome due to severe pneumonia, and was treated with pulse methylprednisolone and sivelestat sodium in combination with intravenous erythromycin and ciprofloxacin." | 7.72 | [A case of Legionella pneumonia complicated with acute respiratory distress syndrome treated with methylprednisolone and sivelestat sodium in combination with intravenous erythromycin and ciprofloxacin]. ( Arinobu, Y; Himeji, D; Kikuchi, I; Kojima, T; Oguma, A; Ueda, A, 2004) |
| "Sivelestat sodium hydrate (ELASPOL) was effective for ARDS in a fifty-year-old female patient suffering from chronic rheumatoid arthritis with acute exacerbation, after failing to respond to high dose steroid pulse therapy." | 7.72 | [Sivelestat sodium hydrate was effective for ARDS in a patient suffering from chronic rheumatoid arthritis with acute exacerbation after failing to respond to high dose steroid pulse therapy]. ( Sugahara, K; Takara, I; Tokumine, J; Tomiyama, H, 2004) |
| " No adverse events were reported during the study period." | 5.62 | Efficacy, safety, and pharmacoeconomics of sivelestat sodium in the treatment of septic acute respiratory distress syndrome: a retrospective cohort study. ( Gao, X; Guo, X; Huang, L; Lei, Z; Tian, J; Yang, Y; Zhang, R, 2021) |
| "Sivelestat is a selective neutrophil elastase inhibitor." | 5.36 | Sivelestat (selective neutrophil elastase inhibitor) improves the mortality rate of sepsis associated with both acute respiratory distress syndrome and disseminated intravascular coagulation patients. ( Gando, S; Hayakawa, M; Hoshino, H; Katabami, K; Sawamura, A; Sugano, M; Wada, T, 2010) |
| "Sivelestat was administered continuously for 7 days with no adverse reactions, and consolidations on a chest radiograph were diminished and impaired oxygenation was markedly alleviated." | 5.35 | Sivelestat treatment for acute respiratory distress syndrome in an infant. ( Goto, K; Hagiwara, S; Hidaka, S; Iwasaka, H; Matsumoto, S; Noguchi, T; Shingu, C, 2009) |
| "Hemodialysis was started for acute renal failure due to rhabdomyolysis, and mechanical ventilation was introduced due to worsening of acute respiratory failure." | 5.34 | [A case of legionella pneumonia associated with acute respiratory distress syndrome (ARDS) and acute renal failure treated with methylprednisolone and sivelestat]. ( Hida, N; Horiuchi, N; Kunikane, H; Naoki, K; Narita, Y; Okamoto, H; Watanabe, K, 2007) |
| "This article summarizes the effects of sivelestat on acute lung injury/acute respiratory distress syndrome (ALI/ARDS) or ARDS with coagulopathy, both of which are frequently seen in patients with COVID-19." | 5.05 | Neutrophil elastase inhibitor (sivelestat) may be a promising therapeutic option for management of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19. ( Avan, R; Bagheri, M; Habtemariam, S; Khataminia, M; Rezai Ghaleno, H; Sadremomtaz, A; Safdari, M; Saghafi, F; Sahebnasagh, A; Talaei, Z, 2020) |
| "To investigate the effect of sivelestat sodium on the prognosis in patients with acute lung injury (ALI) and acute respiratory distress syndrome (ARDS)." | 4.91 | [Effect of sivelestat sodium on the prognosis of patients with acute lung injury and acute respiratory distress syndrome: a meta-analysis]. ( Shang, Y; Sun, Z; Xia, H; Yang, Y; Yao, S, 2015) |
| "We conducted a systematic review and meta-analysis of randomized controlled trials on sivelestat for the treatment of acute lung injury and acute respiratory distress syndrome." | 4.86 | Effect of neutrophil elastase inhibitor (sivelestat sodium) in the treatment of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS): a systematic review and meta-analysis. ( Doi, A; Gremillion, DH; Igarashi, W; Iwata, K; Oba, Y; Ohji, G; Oka, H; Shimada, T; Takimoto, K, 2010) |
| "To compare the protective effect of Xuebijing injection versus Sivelestat sodium on acute lung injury/acute respiratory distress syndrome (ALI/ARDS) rats." | 4.12 | [Comparative study of the protective effect of Xuebijing injection and Sivelestat sodium on acute lung injury/acute respiratory distress syndrome rats]. ( Dong, T; Tian, W, 2022) |
| "Because mortality and postoperative complications were similar, our findings do not support prophylactic sivelestat administration for patients undergoing esophagectomy." | 3.91 | Prophylactic sivelestat for esophagectomy and in-hospital mortality: a propensity score-matched analysis of claims database. ( Kawakami, K; Kawasaki, Y; Kuwauchi, A; Nahara, I; Takeda, C; Takeuchi, M; Tanaka, S; Yonekura, H; Yoshida, S, 2019) |
| "Diquat and glyphosate poisoning were diagnosed by stated ingestion history, and the diagnostic criteria for acute respiratory distress syndrome (ARDS) and multi-organ dysfunction syndrome were also met." | 3.91 | Successful extracorporeal membrane oxygenation support for severe acute diquat and glyphosate poisoning: A case report. ( Hu, J; Luo, J; Wang, D; Zhang, G; Zhang, W; Zhu, L, 2019) |
| "The efficacy of sivelestat, a neutrophil elastase inhibitor, for acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) remains controversial." | 3.85 | Efficacy of early sivelestat administration on acute lung injury and acute respiratory distress syndrome. ( Asakawa, T; Fujino, Y; Kido, T; Kubo, T; Matsuda, S; Mayumi, T; Mukae, H; Muramatsu, K; Otsubo, H; Yatera, K, 2017) |
| "A multicenter retrospective survey of patients poisoned by herbicides containing glyphosate salts in Japan was conducted to identify differences in symptoms and outcome of poisoning." | 3.83 | A multicenter retrospective survey of poisoning after ingestion of herbicides containing glyphosate potassium salt or other glyphosate salts in Japan. ( Kamijo, Y; Sakamoto, T; Takai, M, 2016) |
| "Sivelestat, a selective inhibitor of neutrophil elastase, has been reported to reduce acute lung injury associated with systemic inflammatory response syndrome." | 3.79 | Preventive effect of sivelestat on postoperative respiratory disorders after thoracic esophagectomy. ( Baba, H; Baba, Y; Hirashima, K; Iwatsuki, M; Karashima, R; Kinoshita, K; Kurashige, J; Nagai, Y; Watanabe, M, 2013) |
| "The efficacy of sivelestat in the treatment of acute lung injury/acute respiratory distress syndrome (ALI/ARDS) has not been established." | 3.78 | Clinical evaluation of sivelestat for acute lung injury/acute respiratory distress syndrome following surgery for abdominal sepsis. ( Mii, S; Nakazato, K; Sakamoto, A; Takeda, S; Tanaka, K; Tsuboko, Y; Uchida, E, 2012) |
| "We experienced a case of good response in acute respiratory distress syndrome (ARDS) treated with sivelestat sodium hydrate during chemotherapy for cholangiocarcinoma." | 3.74 | [Good response in ARDS treated with sivelestat sodium hydrate during chemotherapy for cholangiocarcinoma]. ( Hanada, N; Hori, K; Kusano, S; Momi, H, 2007) |
| "We have examined the effect of DL-propargylglycine, a cystathionine gamma-lyase inhibitor, on the synthesis of CC chemokine monocyte chemotactic protein 1, Regulated upon Activation, Normal T-cell Expressed, and Secreted, and macrophage inflammatory protein-1alpha (MIP-1alpha), and CXC chemokine MIP-2 in an in vitro and in vivo model of cerulein-induced acute pancreatitis and associated lung injury." | 3.74 | Inhibition of hydrogen sulfide synthesis attenuates chemokine production and protects mice against acute pancreatitis and associated lung injury. ( Bhatia, M; Moore, PK; Tamizhselvi, R, 2008) |
| "To conduct a cost-minimisation analysis of sivelestat sodium hydrate treatment for patients in the intensive care unit (ICU) with acute lung injury (ALI) associated with systemic inflammatory response syndrome (SIRS) caused by infection." | 3.73 | Cost-minimisation analysis of sivelestat for acute lung injury associated with systemic inflammatory response syndrome. ( Abiru, T; Aikawa, N; Fujishima, S; Kobayashi, M; Matsuoka, S, 2005) |
| "We assessed the effects of a neutrophil elastase inhibitor, sivelestat, on respiratory and organ functions as well as on the mortality of patients with acute respiratory distress syndrome (ARDS) associated with systemic inflammatory response syndrome (SIRS)." | 3.73 | Clinical effects of a neutrophil elastase inhibitor, sivelestat, in patients with acute respiratory distress syndrome. ( Imabayashi, T; Kakihana, Y; Kanmura, Y; Matsunaga, A; Okayama, N; Omae, T; Setoguchi, D, 2006) |
| "Sivelestat sodium hydrate (ELASPOL) was effective for ARDS in a fifty-year-old female patient suffering from chronic rheumatoid arthritis with acute exacerbation, after failing to respond to high dose steroid pulse therapy." | 3.72 | [Sivelestat sodium hydrate was effective for ARDS in a patient suffering from chronic rheumatoid arthritis with acute exacerbation after failing to respond to high dose steroid pulse therapy]. ( Sugahara, K; Takara, I; Tokumine, J; Tomiyama, H, 2004) |
| " He was diagnosed as having acute respiratory distress syndrome due to severe pneumonia, and was treated with pulse methylprednisolone and sivelestat sodium in combination with intravenous erythromycin and ciprofloxacin." | 3.72 | [A case of Legionella pneumonia complicated with acute respiratory distress syndrome treated with methylprednisolone and sivelestat sodium in combination with intravenous erythromycin and ciprofloxacin]. ( Arinobu, Y; Himeji, D; Kikuchi, I; Kojima, T; Oguma, A; Ueda, A, 2004) |
| "Sivelestat-Na was administered by 0." | 2.43 | [Sivelestat sodium for aspiration-related acute lung injury: a review and analysis of published case reports]. ( Hashimoto, S; Shime, N, 2006) |
| " No adverse events were reported during the study period." | 1.62 | Efficacy, safety, and pharmacoeconomics of sivelestat sodium in the treatment of septic acute respiratory distress syndrome: a retrospective cohort study. ( Gao, X; Guo, X; Huang, L; Lei, Z; Tian, J; Yang, Y; Zhang, R, 2021) |
| "The severity of the lung injury was assessed on the basis of vascular permeability, histopathologic evaluation, and lung mechanics." | 1.46 | Evaluation of Lecithinized Superoxide Dismutase for the Prevention of Acute Respiratory Distress Syndrome in Animal Models. ( Imai, Y; Kawahara, M; Kuba, K; Mizushima, T; Sugizaki, T; Tamura, F; Tanaka, KI, 2017) |
| "Sivelestat is a selective neutrophil elastase inhibitor." | 1.36 | Sivelestat (selective neutrophil elastase inhibitor) improves the mortality rate of sepsis associated with both acute respiratory distress syndrome and disseminated intravascular coagulation patients. ( Gando, S; Hayakawa, M; Hoshino, H; Katabami, K; Sawamura, A; Sugano, M; Wada, T, 2010) |
| "Sivelestat was administered continuously for 7 days with no adverse reactions, and consolidations on a chest radiograph were diminished and impaired oxygenation was markedly alleviated." | 1.35 | Sivelestat treatment for acute respiratory distress syndrome in an infant. ( Goto, K; Hagiwara, S; Hidaka, S; Iwasaka, H; Matsumoto, S; Noguchi, T; Shingu, C, 2009) |
| "After 10 postoperative days, he had acute respiratory distress syndrome." | 1.35 | Successful management of postoperative acute respiratory distress syndrome in a patient with lung cancer. ( Hiroshima, K; Iyoda, A; Moriya, Y; Shibuya, K; Yoshino, I, 2008) |
| "Hemodialysis was started for acute renal failure due to rhabdomyolysis, and mechanical ventilation was introduced due to worsening of acute respiratory failure." | 1.34 | [A case of legionella pneumonia associated with acute respiratory distress syndrome (ARDS) and acute renal failure treated with methylprednisolone and sivelestat]. ( Hida, N; Horiuchi, N; Kunikane, H; Naoki, K; Narita, Y; Okamoto, H; Watanabe, K, 2007) |
| "Treatment with Sivelestat, a small molecule inhibitor of neutrophil elastase, achieved rapid improvement in oxygenation and chest radiograph findings, and the patient has been in complete remission for 24 months." | 1.33 | Sivelestat relieves respiratory distress refractory to dexamethasone in all-trans retinoic acid syndrome: a report of two cases. ( Akaike, H; Kawasaki, K; Miyauchi, A; Ouchi, K, 2006) |
| "Treatment with sivelestat sodium hydrate also decreased serum neutrophil elastase activity." | 1.33 | [Survival by a young woman with malnutrition due to alcoholism and eating disorders and with acute respiratory distress syndrome due to severe pneumonia who showed increased serum neutrophil elastase activity]. ( Nakajima, H; Nakajima, S; Sawaguchi, H, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (8.47) | 18.2507 |
| 2000's | 33 (55.93) | 29.6817 |
| 2010's | 16 (27.12) | 24.3611 |
| 2020's | 5 (8.47) | 2.80 |
| Authors | Studies |
|---|---|
| Gao, X | 1 |
| Zhang, R | 1 |
| Lei, Z | 1 |
| Guo, X | 1 |
| Yang, Y | 2 |
| Tian, J | 1 |
| Huang, L | 1 |
| Harnisch, LO | 4 |
| Mihaylov, D | 4 |
| Bein, T | 4 |
| Apfelbacher, C | 4 |
| Kiehntopf, M | 1 |
| Bauer, M | 1 |
| Moerer, O | 4 |
| Quintel, M | 4 |
| Tian, W | 1 |
| Dong, T | 1 |
| Sahebnasagh, A | 1 |
| Saghafi, F | 1 |
| Safdari, M | 1 |
| Khataminia, M | 1 |
| Sadremomtaz, A | 1 |
| Talaei, Z | 1 |
| Rezai Ghaleno, H | 1 |
| Bagheri, M | 1 |
| Habtemariam, S | 1 |
| Avan, R | 1 |
| Takeda, C | 1 |
| Takeuchi, M | 1 |
| Kawasaki, Y | 1 |
| Yonekura, H | 1 |
| Nahara, I | 1 |
| Kuwauchi, A | 1 |
| Yoshida, S | 1 |
| Tanaka, S | 1 |
| Kawakami, K | 1 |
| Wang, D | 1 |
| Zhang, G | 1 |
| Zhang, W | 1 |
| Luo, J | 1 |
| Zhu, L | 1 |
| Hu, J | 1 |
| Nagai, Y | 1 |
| Watanabe, M | 1 |
| Baba, Y | 1 |
| Iwatsuki, M | 1 |
| Hirashima, K | 1 |
| Karashima, R | 1 |
| Kurashige, J | 1 |
| Kinoshita, K | 1 |
| Baba, H | 1 |
| Lee, SK | 1 |
| Son, BS | 1 |
| Hwang, JJ | 1 |
| Kim, KD | 1 |
| Kim, DH | 1 |
| Izumida, H | 1 |
| Fujishima, S | 2 |
| Miyoshi, S | 1 |
| Ito, R | 1 |
| Katayama, H | 1 |
| Dote, K | 1 |
| Aibiki, M | 1 |
| Hamada, H | 1 |
| Okura, T | 1 |
| Higaki, J | 1 |
| Kamijo, Y | 1 |
| Takai, M | 1 |
| Sakamoto, T | 1 |
| Xia, H | 1 |
| Sun, Z | 1 |
| Shang, Y | 1 |
| Yao, S | 1 |
| Tanaka, KI | 1 |
| Tamura, F | 1 |
| Sugizaki, T | 1 |
| Kawahara, M | 1 |
| Kuba, K | 1 |
| Imai, Y | 1 |
| Mizushima, T | 1 |
| Kido, T | 1 |
| Muramatsu, K | 1 |
| Yatera, K | 1 |
| Asakawa, T | 1 |
| Otsubo, H | 1 |
| Kubo, T | 1 |
| Fujino, Y | 2 |
| Matsuda, S | 1 |
| Mayumi, T | 1 |
| Mukae, H | 1 |
| Iyoda, A | 1 |
| Moriya, Y | 1 |
| Hiroshima, K | 1 |
| Shibuya, K | 1 |
| Yoshino, I | 1 |
| Matsumoto, S | 2 |
| Hidaka, S | 1 |
| Goto, K | 1 |
| Hagiwara, S | 1 |
| Shingu, C | 1 |
| Iwasaka, H | 1 |
| Noguchi, T | 1 |
| Hayakawa, M | 1 |
| Katabami, K | 1 |
| Wada, T | 1 |
| Sugano, M | 1 |
| Hoshino, H | 1 |
| Sawamura, A | 1 |
| Gando, S | 1 |
| Iwata, K | 1 |
| Doi, A | 1 |
| Ohji, G | 1 |
| Oka, H | 1 |
| Oba, Y | 1 |
| Takimoto, K | 1 |
| Igarashi, W | 1 |
| Gremillion, DH | 1 |
| Shimada, T | 1 |
| Yamaguchi, K | 1 |
| Sugasawa, Y | 1 |
| Takeuchi, K | 1 |
| Kugimiya, T | 1 |
| Kumakura, S | 1 |
| Iwanuma, Y | 1 |
| Kajiyama, Y | 1 |
| Tsurumaru, M | 1 |
| Nagaoka, I | 1 |
| Inada, E | 1 |
| Fujino, N | 1 |
| Kubo, H | 1 |
| Suzuki, T | 2 |
| He, M | 1 |
| Yamada, M | 1 |
| Takahashi, T | 1 |
| Ota, C | 1 |
| Yamaya, M | 1 |
| Tsuboko, Y | 1 |
| Takeda, S | 1 |
| Mii, S | 1 |
| Nakazato, K | 1 |
| Tanaka, K | 1 |
| Uchida, E | 1 |
| Sakamoto, A | 1 |
| Zouaoui, K | 1 |
| Dulaurent, S | 1 |
| Gaulier, JM | 1 |
| Moesch, C | 1 |
| Lachâtre, G | 1 |
| Bellomo, R | 1 |
| Uchino, S | 1 |
| Naka, T | 1 |
| Wan, L | 1 |
| Zeiher, BG | 2 |
| Artigas, A | 1 |
| Vincent, JL | 1 |
| Dmitrienko, A | 1 |
| Jackson, K | 1 |
| Thompson, BT | 1 |
| Bernard, G | 1 |
| Kadoi, Y | 1 |
| Hinohara, H | 1 |
| Kunimoto, F | 1 |
| Saito, S | 1 |
| Goto, F | 1 |
| Kosaka, T | 1 |
| Ieta, K | 1 |
| Tamakuma, S | 1 |
| Ogawa, M | 1 |
| Aikawa, N | 2 |
| Kubota, T | 1 |
| Hirasawa, H | 1 |
| Ishizaka, A | 2 |
| Taenaka, N | 1 |
| Hamada, C | 1 |
| Matsuoka, S | 3 |
| Abiru, T | 2 |
| Tomiyama, H | 1 |
| Takara, I | 1 |
| Tokumine, J | 1 |
| Sugahara, K | 1 |
| Oguma, A | 1 |
| Kojima, T | 1 |
| Himeji, D | 1 |
| Arinobu, Y | 1 |
| Kikuchi, I | 1 |
| Ueda, A | 1 |
| Kobayashi, M | 1 |
| Inoue, Y | 2 |
| Seiyama, A | 1 |
| Tanaka, H | 2 |
| Ukai, I | 2 |
| Akimau, P | 1 |
| Nishino, M | 1 |
| Shimazu, T | 2 |
| Sugimoto, H | 2 |
| Hoshi, K | 1 |
| Kurosawa, S | 1 |
| Kato, M | 1 |
| Andoh, K | 1 |
| Satoh, D | 1 |
| Kaise, A | 1 |
| Okayama, N | 1 |
| Kakihana, Y | 1 |
| Setoguchi, D | 1 |
| Imabayashi, T | 1 |
| Omae, T | 1 |
| Matsunaga, A | 1 |
| Kanmura, Y | 1 |
| Santacruz, JF | 1 |
| Diaz Guzman Zavala, E | 1 |
| Arroliga, AC | 1 |
| Ryugo, M | 1 |
| Sawa, Y | 1 |
| Takano, H | 1 |
| Matsumiya, G | 1 |
| Iwai, S | 1 |
| Ono, M | 1 |
| Hata, H | 1 |
| Yamauchi, T | 1 |
| Nishimura, M | 1 |
| Matsuda, H | 1 |
| Ogura, H | 1 |
| Fujita, K | 1 |
| Hosotsubo, H | 1 |
| Shime, N | 2 |
| Hashimoto, S | 2 |
| Minami, T | 1 |
| Kito, K | 1 |
| Kawasaki, K | 1 |
| Akaike, H | 1 |
| Miyauchi, A | 1 |
| Ouchi, K | 1 |
| Utsugi, M | 1 |
| Ishizuka, T | 1 |
| Hisada, T | 1 |
| Shimizu, Y | 1 |
| Dobashi, K | 1 |
| Mori, M | 1 |
| Nakajima, H | 1 |
| Sawaguchi, H | 1 |
| Nakajima, S | 1 |
| Wakayama, F | 1 |
| Fukuda, I | 1 |
| Suzuki, Y | 1 |
| Kondo, N | 1 |
| Jessen, ME | 1 |
| Yoshida, T | 1 |
| Rinka, H | 1 |
| Kaji, A | 1 |
| Kodama, T | 1 |
| Yukioka, H | 1 |
| Kato, T | 1 |
| Kato, N | 1 |
| Hato, F | 1 |
| Kitagawa, S | 1 |
| Narita, Y | 1 |
| Naoki, K | 1 |
| Horiuchi, N | 1 |
| Hida, N | 1 |
| Okamoto, H | 1 |
| Kunikane, H | 1 |
| Watanabe, K | 1 |
| Hanada, N | 1 |
| Kusano, S | 1 |
| Hori, K | 1 |
| Momi, H | 1 |
| Okayama, Y | 1 |
| Kimura, A | 1 |
| Funakoshi, Y | 1 |
| Kawabata, K | 3 |
| Amaya, F | 1 |
| Nagashima, M | 1 |
| Kunisawa, T | 1 |
| Kurosawa, A | 1 |
| Takahashi, K | 1 |
| Harada, H | 1 |
| Takahata, O | 1 |
| Iwasaki, H | 1 |
| Kakeya, H | 1 |
| Ehara, N | 1 |
| Fukushima, K | 1 |
| Seki, M | 1 |
| Izumikawa, K | 1 |
| Yamamoto, Y | 1 |
| Yanagihara, K | 1 |
| Saito, A | 1 |
| Kohno, S | 1 |
| Tamizhselvi, R | 1 |
| Moore, PK | 1 |
| Bhatia, M | 1 |
| Yasui, S | 1 |
| Nagai, A | 1 |
| Aoshiba, K | 1 |
| Ozawa, Y | 1 |
| Kakuta, Y | 1 |
| Konno, K | 1 |
| van Heerden, PV | 1 |
| Power, BM | 1 |
| Leonard, RC | 1 |
| Nishina, K | 1 |
| Mikawa, K | 1 |
| Takao, Y | 1 |
| Maekawa, N | 1 |
| Shiga, M | 1 |
| Obara, H | 1 |
| Miyazaki, Y | 1 |
| Inoue, T | 1 |
| Kyi, M | 1 |
| Sawada, M | 1 |
| Miyake, S | 1 |
| Yoshizawa, Y | 1 |
| Kitamura, S | 1 |
| Hagio, T | 1 |
| Nakao, S | 1 |
| Orita, S | 1 |
| Aze, Y | 1 |
| Ohno, H | 1 |
| Quasney, MW | 1 |
| Waterer, GW | 1 |
| Dahmer, MK | 1 |
| Turner, D | 1 |
| Zhang, Q | 1 |
| Cantor, RM | 1 |
| Wunderink, RG | 1 |
| Repine, JE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pirfenidone to Prevent Fibrosis in ARDS. A Randomized Controlled Trial - PIONEER[NCT05075161] | Phase 3 | 130 participants (Anticipated) | Interventional | 2022-06-01 | Recruiting | ||
| Retrospective Study of Intrapleural Methylprednisolone Injection for Multiple Organ Failure With Acute Respiratory Distress Syndrome[NCT01423864] | Phase 2 | 29 participants (Actual) | Interventional | 2005-06-30 | Completed | ||
| A Pilot Study of Perioperative Application of Sivelestat Sodium in Acute Type A Aortic Dissection Patients With Preoperative Moderate to Severe Hypoxemia to Shorten the Duration of Postoperative Invasive Mechanical Ventilation[NCT05874700] | 30 participants (Anticipated) | Interventional | 2023-05-31 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 reviews available for glycine and Respiratory Distress Syndrome
| Article | Year |
|---|---|
Neutrophil elastase inhibitor (sivelestat) may be a promising therapeutic option for management of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19.
Topics: Acute Lung Injury; COVID-19; COVID-19 Drug Treatment; Disseminated Intravascular Coagulation; Glycin | 2020 |
[Pharmacological therapies for ARDS].
Topics: Animals; Anticoagulants; Atracurium; Disseminated Intravascular Coagulation; Glycine; Humans; Meta-A | 2013 |
[Effect of sivelestat sodium on the prognosis of patients with acute lung injury and acute respiratory distress syndrome: a meta-analysis].
Topics: Acute Lung Injury; China; Glycine; Humans; Intensive Care Units; Length of Stay; Prognosis; Randomiz | 2015 |
Effect of neutrophil elastase inhibitor (sivelestat sodium) in the treatment of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS): a systematic review and meta-analysis.
Topics: Acute Lung Injury; Glycine; Humans; Proteinase Inhibitory Proteins, Secretory; Randomized Controlled | 2010 |
Update in ARDS management: recent randomized controlled trials that changed our practice.
Topics: Glycine; High-Frequency Ventilation; Humans; Liquid Ventilation; Nitric Oxide; Ohio; Positive-Pressu | 2006 |
[Sivelestat sodium for aspiration-related acute lung injury: a review and analysis of published case reports].
Topics: Aged; Aged, 80 and over; Female; Glycine; Humans; Male; Middle Aged; Pneumonia, Aspiration; Respirat | 2006 |
[The 74th Annual Meeting President Lecture. Pathogenesis and therapy of acute lung injury].
Topics: Glycine; Humans; Leukocyte Elastase; Respiratory Distress Syndrome; Serine Proteinase Inhibitors; Su | 1999 |
7 trials available for glycine and Respiratory Distress Syndrome
| Article | Year |
|---|---|
Effects of sivelestat on bronchial inflammatory responses after esophagectomy.
Topics: Acute Lung Injury; Aged; Bronchitis; Esophagectomy; Female; Glycine; Humans; Interleukin-6; Interleu | 2011 |
Neutrophil elastase inhibition in acute lung injury: results of the STRIVE study.
Topics: Australia; Belgium; Canada; Double-Blind Method; Female; Follow-Up Studies; Glycine; Guideline Adher | 2004 |
Pilot study of the effects of ONO-5046 in patients with acute respiratory distress syndrome.
Topics: Adult; Aged; Cytokines; Double-Blind Method; Female; Glycine; Humans; Leukocyte Elastase; Male; Midd | 2004 |
Relationship between neutrophil elastase and acute lung injury in humans.
Topics: Adolescent; Adult; Aged; Dose-Response Relationship, Drug; Double-Blind Method; Female; Glycine; Hum | 2004 |
Effect of a polymorphonuclear elastase inhibitor (sivelestat sodium) on acute lung injury after cardiopulmonary bypass: findings of a double-blind randomized study.
Topics: Acute Disease; Aged; Cardiopulmonary Bypass; Female; Glycine; Humans; Interleukin-8; Leukocyte Elast | 2006 |
A neutrophil elastase inhibitor, sivelestat, improves leukocyte deformability in patients with acute lung injury.
Topics: Adult; Aged; APACHE; C-Reactive Protein; Cell Membrane; Elasticity; Female; Glycine; Humans; Leukocy | 2006 |
Neutrophil elastase as a predicting factor for development of acute lung injury.
Topics: Adult; Aged; Aged, 80 and over; Female; Glycine; Humans; Leukocyte Elastase; Male; Middle Aged; Pred | 2007 |
45 other studies available for glycine and Respiratory Distress Syndrome
| Article | Year |
|---|---|
Efficacy, safety, and pharmacoeconomics of sivelestat sodium in the treatment of septic acute respiratory distress syndrome: a retrospective cohort study.
Topics: Economics, Pharmaceutical; Glycine; Humans; Respiratory Distress Syndrome; Retrospective Studies; So | 2021 |
Determination of individual bile acids in acute respiratory distress syndrome reveals a specific pattern of primary and secondary bile acids and a shift to the acidic pathway as an adaptive response to the critical condition.
Topics: Bile Acids and Salts; Chenodeoxycholic Acid; Glycine; Humans; Respiratory Distress Syndrome; Taurine | 2022 |
[Comparative study of the protective effect of Xuebijing injection and Sivelestat sodium on acute lung injury/acute respiratory distress syndrome rats].
Topics: Acute Lung Injury; Animals; Drugs, Chinese Herbal; Glycine; Interleukin-6; Lipopolysaccharides; Lung | 2022 |
A reduced glycine-to-taurine ratio of conjugated serum bile acids signifies an adaptive mechanism and is an early marker of outcome in acute respiratory distress syndrome.
Topics: Bile Acids and Salts; Chromatography, Liquid; Glycine; Humans; Respiratory Distress Syndrome; Tandem | 2023 |
A reduced glycine-to-taurine ratio of conjugated serum bile acids signifies an adaptive mechanism and is an early marker of outcome in acute respiratory distress syndrome.
Topics: Bile Acids and Salts; Chromatography, Liquid; Glycine; Humans; Respiratory Distress Syndrome; Tandem | 2023 |
A reduced glycine-to-taurine ratio of conjugated serum bile acids signifies an adaptive mechanism and is an early marker of outcome in acute respiratory distress syndrome.
Topics: Bile Acids and Salts; Chromatography, Liquid; Glycine; Humans; Respiratory Distress Syndrome; Tandem | 2023 |
A reduced glycine-to-taurine ratio of conjugated serum bile acids signifies an adaptive mechanism and is an early marker of outcome in acute respiratory distress syndrome.
Topics: Bile Acids and Salts; Chromatography, Liquid; Glycine; Humans; Respiratory Distress Syndrome; Tandem | 2023 |
A reduced glycine-to-taurine ratio of conjugated serum bile acids signifies an adaptive mechanism and is an early marker of outcome in acute respiratory distress syndrome.
Topics: Bile Acids and Salts; Chromatography, Liquid; Glycine; Humans; Respiratory Distress Syndrome; Tandem | 2023 |
A reduced glycine-to-taurine ratio of conjugated serum bile acids signifies an adaptive mechanism and is an early marker of outcome in acute respiratory distress syndrome.
Topics: Bile Acids and Salts; Chromatography, Liquid; Glycine; Humans; Respiratory Distress Syndrome; Tandem | 2023 |
A reduced glycine-to-taurine ratio of conjugated serum bile acids signifies an adaptive mechanism and is an early marker of outcome in acute respiratory distress syndrome.
Topics: Bile Acids and Salts; Chromatography, Liquid; Glycine; Humans; Respiratory Distress Syndrome; Tandem | 2023 |
A reduced glycine-to-taurine ratio of conjugated serum bile acids signifies an adaptive mechanism and is an early marker of outcome in acute respiratory distress syndrome.
Topics: Bile Acids and Salts; Chromatography, Liquid; Glycine; Humans; Respiratory Distress Syndrome; Tandem | 2023 |
A reduced glycine-to-taurine ratio of conjugated serum bile acids signifies an adaptive mechanism and is an early marker of outcome in acute respiratory distress syndrome.
Topics: Bile Acids and Salts; Chromatography, Liquid; Glycine; Humans; Respiratory Distress Syndrome; Tandem | 2023 |
Prophylactic sivelestat for esophagectomy and in-hospital mortality: a propensity score-matched analysis of claims database.
Topics: Aged; Databases, Factual; Esophagectomy; Female; Glycine; Hospitals; Humans; Japan; Male; Middle Age | 2019 |
Successful extracorporeal membrane oxygenation support for severe acute diquat and glyphosate poisoning: A case report.
Topics: Adult; Diquat; Extracorporeal Membrane Oxygenation; Glycine; Glyphosate; Humans; Male; Multiple Orga | 2019 |
Preventive effect of sivelestat on postoperative respiratory disorders after thoracic esophagectomy.
Topics: Acute Lung Injury; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents; Drug Administration Sch | 2013 |
The use of neutrophil elastase inhibitor in the treatment of acute lung injury after pneumonectomy.
Topics: Acute Lung Injury; Adult; Aged; Combined Modality Therapy; Drug Administration Schedule; Glycine; Hu | 2013 |
Combination therapy with sivelestat and recombinant human soluble thrombomodulin for ARDS and DIC patients.
Topics: Aged; Disseminated Intravascular Coagulation; Drug Therapy, Combination; Female; Glycine; Humans; Ma | 2014 |
A multicenter retrospective survey of poisoning after ingestion of herbicides containing glyphosate potassium salt or other glyphosate salts in Japan.
Topics: Acute Lung Injury; Adult; Aged; Aged, 80 and over; Chemical and Drug Induced Liver Injury; Dose-Resp | 2016 |
Evaluation of Lecithinized Superoxide Dismutase for the Prevention of Acute Respiratory Distress Syndrome in Animal Models.
Topics: Animals; Cecum; Dexamethasone; Disease Models, Animal; Glycine; Ligation; Lipopolysaccharides; Lung | 2017 |
Efficacy of early sivelestat administration on acute lung injury and acute respiratory distress syndrome.
Topics: Acute Lung Injury; Aged; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Fol | 2017 |
Successful management of postoperative acute respiratory distress syndrome in a patient with lung cancer.
Topics: Adrenal Cortex Hormones; Aged; Drug Therapy, Combination; Glycine; Humans; Lung Neoplasms; Male; Pne | 2008 |
Sivelestat treatment for acute respiratory distress syndrome in an infant.
Topics: Anti-Inflammatory Agents; C-Reactive Protein; Cardiopulmonary Resuscitation; Glycine; Humans; Hypoxi | 2009 |
Sivelestat (selective neutrophil elastase inhibitor) improves the mortality rate of sepsis associated with both acute respiratory distress syndrome and disseminated intravascular coagulation patients.
Topics: Adult; Aged; Disseminated Intravascular Coagulation; Female; Glycine; Humans; Male; Middle Aged; Res | 2010 |
Administration of a specific inhibitor of neutrophil elastase attenuates pulmonary fibrosis after acute lung injury in mice.
Topics: Acute Lung Injury; Animals; Bronchoalveolar Lavage Fluid; Cell Movement; Collagen; Glycine; Leukocyt | 2012 |
Clinical evaluation of sivelestat for acute lung injury/acute respiratory distress syndrome following surgery for abdominal sepsis.
Topics: Abdomen; Acute Lung Injury; Aged; Female; Glycine; Humans; Male; Middle Aged; Postoperative Complica | 2012 |
Determination of glyphosate and AMPA in blood and urine from humans: about 13 cases of acute intoxication.
Topics: Accidents; Acidosis; Adult; Aged; Arrhythmias, Cardiac; Chemical and Drug Induced Liver Injury; Chro | 2013 |
Hidden evidence to the West: multicentre, randomised, controlled trials in sepsis and systemic inflammatory response syndrome in Japanese journals.
Topics: Anti-Inflammatory Agents; Communication Barriers; Double-Blind Method; Evidence-Based Medicine; Glyc | 2004 |
[Sivelestat sodium hydrate was effective for ARDS in a patient suffering from chronic rheumatoid arthritis with acute exacerbation after failing to respond to high dose steroid pulse therapy].
Topics: Antigens; Antigens, Neoplasm; Arthritis, Rheumatoid; Biomarkers; Female; Glycine; Glycoproteins; Hum | 2004 |
[A case of Legionella pneumonia complicated with acute respiratory distress syndrome treated with methylprednisolone and sivelestat sodium in combination with intravenous erythromycin and ciprofloxacin].
Topics: Anti-Infective Agents; Ciprofloxacin; Drug Therapy, Combination; Erythromycin; Glycine; Humans; Infu | 2004 |
Cost-minimisation analysis of sivelestat for acute lung injury associated with systemic inflammatory response syndrome.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Cost Savings; Female; Glycine; Health Care Costs; Humans | 2005 |
Protective effects of a selective neutrophil elastase inhibitor (sivelestat) on lipopolysaccharide-induced acute dysfunction of the pulmonary microcirculation.
Topics: Analysis of Variance; Animals; Cell Adhesion; Glycine; Hemodynamics; Leukocyte Elastase; Leukocytes; | 2005 |
Sivelestat, a neutrophil elastase inhibitor, reduces mortality rate of critically ill patients.
Topics: Aged; Aged, 80 and over; Critical Illness; Female; Glycine; Hospitals, University; Hospitals, Urban; | 2005 |
Clinical effects of a neutrophil elastase inhibitor, sivelestat, in patients with acute respiratory distress syndrome.
Topics: Aged; Female; Glycine; Humans; Leukocyte Elastase; Male; Middle Aged; Respiratory Distress Syndrome; | 2006 |
[Prophylactic effects of neutrophil elastase inhibitor for patients undergoing surgery for thoracic aortic aneurysm: a retrospective study].
Topics: Aged; Aged, 80 and over; Aortic Aneurysm, Thoracic; Cardiopulmonary Bypass; Female; Glycine; Humans; | 2006 |
Sivelestat relieves respiratory distress refractory to dexamethasone in all-trans retinoic acid syndrome: a report of two cases.
Topics: Anthracyclines; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Cytoprotection; Dexameth | 2006 |
Acute respiratory failure associated with miliary tuberculosis successfully treated with sivelestat sodium hydrate.
Topics: Antitubercular Agents; Glycine; Humans; Male; Middle Aged; Respiratory Distress Syndrome; Serine Pro | 2006 |
[Survival by a young woman with malnutrition due to alcoholism and eating disorders and with acute respiratory distress syndrome due to severe pneumonia who showed increased serum neutrophil elastase activity].
Topics: Adult; Alcoholism; Feeding and Eating Disorders; Female; Glycine; Humans; Leukocyte Elastase; Malnut | 2006 |
Neutrophil elastase inhibitor, sivelestat, attenuates acute lung injury after cardiopulmonary bypass in the rabbit endotoxemia model.
Topics: Animals; Cardiopulmonary Bypass; Glycine; Interleukin-8; Leukocyte Elastase; Lipopolysaccharides; Ne | 2007 |
Invited commentary.
Topics: Animals; Cardiopulmonary Bypass; Glycine; Leukocyte Elastase; Lipopolysaccharides; Rabbits; Respirat | 2007 |
[A case of idiopathic ARDS treated by sivelestat sodium and fluid management based on extravascular lung water index].
Topics: Aged; Extravascular Lung Water; Female; Fluid Therapy; Glycine; Humans; Leukocyte Elastase; Respirat | 2006 |
[A case of legionella pneumonia associated with acute respiratory distress syndrome (ARDS) and acute renal failure treated with methylprednisolone and sivelestat].
Topics: Acute Kidney Injury; Glucocorticoids; Glycine; Humans; Legionnaires' Disease; Male; Methylprednisolo | 2007 |
[Good response in ARDS treated with sivelestat sodium hydrate during chemotherapy for cholangiocarcinoma].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; | 2007 |
Neutrophil elastase activity in acute lung injury and respiratory distress syndrome.
Topics: Aged; alpha 1-Antitrypsin; Enzyme Inhibitors; Female; Glycine; Humans; Leukocyte Elastase; Male; Mid | 2008 |
[Case of severe transfusion-related acute lung injury during coronary artery bypass surgery].
Topics: Aged; Angina Pectoris; Antibodies; Coronary Artery Bypass; Glycine; Granulocytes; HLA Antigens; Huma | 2008 |
Severe Legionnaires' disease successfully treated using a combination of fluoroquinolone, erythromycin, corticosteroid, and sivelestat.
Topics: Adrenal Cortex Hormones; Aged; Anti-Bacterial Agents; Drug Therapy, Combination; Erythromycin; Fluor | 2008 |
Inhibition of hydrogen sulfide synthesis attenuates chemokine production and protects mice against acute pancreatitis and associated lung injury.
Topics: Acute Disease; Alkynes; Animals; Ceruletide; Chemokine CCL5; Chemokines; Cystathionine gamma-Lyase; | 2008 |
A specific neutrophil elastase inhibitor (ONO-5046.Na) attenuates LPS-induced acute lung inflammation in the hamster.
Topics: Animals; Bronchoalveolar Lavage Fluid; Cell Count; Chemotaxis, Leukocyte; Cricetinae; Glycine; Leuko | 1995 |
Re: Delivery of inhaled aerosolized prostacyclin (IAP)
Topics: Administration, Inhalation; Aerosols; Buffers; Epoprostenol; Equipment Design; Glycine; Humans; Hype | 1996 |
ONO-5046, an elastase inhibitor, attenuates endotoxin-induced acute lung injury in rabbits.
Topics: Airway Resistance; Animals; Bronchoalveolar Lavage Fluid; Endotoxins; Escherichia coli; Glycine; Hem | 1997 |
Effects of a neutrophil elastase inhibitor (ONO-5046) on acute pulmonary injury induced by tumor necrosis factor alpha (TNFalpha) and activated neutrophils in isolated perfused rabbit lungs.
Topics: Animals; Capillary Permeability; Carcinogens; Disease Models, Animal; Drug Evaluation, Preclinical; | 1998 |
Delayed neutrophil elastase inhibition prevents subsequent progression of acute lung injury induced by endotoxin inhalation in hamsters.
Topics: Animals; Bronchoalveolar Lavage Fluid; Cricetinae; Disease Progression; Endotoxins; Glycine; Leukocy | 2000 |
Intracellular adhesion molecule Gly241Arg polymorphism has no impact on ARDS or septic shock in community-acquired pneumonia.
Topics: Arginine; Community-Acquired Infections; Genetic Predisposition to Disease; Glycine; Humans; Interce | 2002 |
Neutrophil elastase and acute lung injury: prospects for sivelestat and other neutrophil elastase inhibitors as therapeutics.
Topics: Animals; Endothelium, Vascular; Glycine; Humans; Leukocyte Elastase; Oxidative Stress; Respiratory D | 2002 |