glycine and Reperfusion Injury studies

Reperfusion Injury: Adverse functional, metabolic, or structural changes in tissues that result from the restoration of blood flow to the tissue (REPERFUSION) following ISCHEMIA.

Research Excerpts

Excerpt	Relevance	Reference
"Donor preconditioning with glycine prevents Kupffer cell-dependent reperfusion injury to liver grafts."	7.91	Glycine protects partial liver grafts from Kupffer cell-dependent ischemia-reperfusion injury without negative effect on regeneration. ( Al-Saeedi, M; Herr, I; Liang, R; Nickkholgh, A; Schemmer, P; Schultze, DP; Zorn, M, 2019)
" In previous study, we linked the anti-inflammatory amino acid glycine to nitronyl nitroxide and developed a novel glycine-nitronyl nitroxide (GNN) conjugate, which showed a synergetic protection against renal ischemia/reperfusion injury."	7.85	Glycine-nitronyl nitroxide conjugate protects human umbilical vein endothelial cells against hypoxia/reoxygenation injury via multiple mechanisms and ameliorates hind limb ischemia/reperfusion injury in rats. ( Bi, W; Bi, Y; Chi, K; Gao, X; Li, X; Liu, Y; Yuan, T, 2017)
" To determine the role of non-ionotropic activity of NMDARs in clinical relevant conditions, we tested the effect of glycine, a co-agonist of NMDARs, in rat middle cerebral artery occlusion (MCAO), an animal model of cerebral ischemia-reperfusion injury after the animals were injected with the NMDAR channel blocker MK-801 and the glycine receptor antagonist strychnine."	7.85	A non-ionotropic activity of NMDA receptors contributes to glycine-induced neuroprotection in cerebral ischemia-reperfusion injury. ( Chen, J; Feng, H; Hu, R; Jin, P; Lei, R; Liao, H; Wan, Q; Wan, Y; Zhang, Y; Zhang, Z; Zhuang, Y, 2017)
"The present study was designed to investigate the role of glycine in ischemia reperfusion-induced acute kidney injury (AKI) in rats."	7.80	Glycine aggravates ischemia reperfusion-induced acute kidney injury through N-Methyl-D-Aspartate receptor activation in rats. ( Arora, S; Kaur, A; Kaur, T; Singh, AP, 2014)
"Glycine is well known to protect the intestine against ischemia-reperfusion injury and during mechanical manipulation."	7.80	Glycine selectively reduces intestinal injury during endotoxemia. ( de Groot, H; Effenberger-Neidnicht, K; Jägers, J; Verhaegh, R, 2014)
"Sivelestat sodium hydrate (sivelestat) is a specific neutrophil elastase inhibitor that is effective in treating acute lung injury associated with systemic inflammatory response syndrome."	7.80	Sivelestat sodium hydrate inhibits neutrophil migration to the vessel wall and suppresses hepatic ischemia-reperfusion injury. ( Fujimura, T; Fushida, S; Hayashi, H; Kitagawa, H; Makino, I; Miyashita, T; Munesue, S; Nakagawara, H; Nakanuma, S; Ohta, T; Saito, H; Sakai, S; Tajima, H; Yamamoto, Y, 2014)
"This study shows that preconditioning with taurine or glycine is equally effective in preventing injury to fatty livers most likely via Kupffer cell-dependent mechanisms."	7.77	Glycine and taurine equally prevent fatty livers from Kupffer cell-dependent injury: an in vivo microscopy study. ( Bruns, H; Büchler, MW; Flechtenmacher, C; Galli, U; Gebhard, MM; Schemmer, P; Schulze-Bergkamen, H; Watanpour, I; Zorn, M, 2011)
" Glycine is an effective anti-inflammatory, cytoprotective agent and is reported to have a beneficial effect against ischemia/reperfusion injury in various organs."	7.75	Renal ischemia/reperfusion injury in rats is attenuated by a synthetic glycine derivative. ( Baudy-Floc'h, M; Bi, L; Bi, W; Bi, Y; Gao, X; Li, M; Liu, S; Ngerebara, N; Robinson, SC; Wang, F; Wang, T; Wang, Z; Xue, P; Zhang, Y, 2009)
" In the present study, we investigated the effect of sivelestat, a neutrophil elastase inhibitor, on reperfusion injury of a donor lung that was harvested from endotoxin-primed animals in a rat lung transplantation model."	7.74	Sivelestat reduces reperfusion injury of lungs harvested from endotoxin-primed rats by inhibition of neutrophil-mediated inflammation. ( Kondo, T; Niikawa, H; Oishi, H; Sugawara, T; Suzuki, S; Tabata, T, 2007)
"In the present study, we evaluated the effect of neutrophil elastase inhibitor, sivelestat sodium hydrate on ischemia-reperfusion injury in the rat bladder."	7.74	Neutrophil elastase inhibitor, sivelestat sodium hydrate prevents ischemia-reperfusion injury in the rat bladder. ( Kono, T; Okada, S; Saito, M, 2008)
"Glycine could efficiently protect rat liver grafts from ischemia-reperfusion injury by repressing the expression of CD14 and NF-kappa B binding activity in Kupffer cells and inhibiting the productions of TNF alpha and IL-1."	7.73	[The effect of glycine on CD14 and NF-kappa B in Kupffer cells from rat liver grafts after ischemia-reperfusion injury]. ( Gan, L; Gong, JP; Li, SB; Li, SW; Liu, CA; Peng, Y, 2005)
"To determine whether glycine could downregulate interleukin 1 receptor associated kinase-4 (IRAK-4) expression to interfere with lipopolysaccharides (LPS) signal transduction and blunt transplantative liver ischemia-reperfusion injury (I/RI)."	7.73	Glycine blunts transplantative liver ischemia-reperfusion injury by downregulating interleukin 1 receptor associated kinase-4. ( Gong, JP; Li, SW; Liu, ZJ; Yan, LN; You, HB, 2006)
"Glycine improved mucosal viability in the ischemia and reperfusion injury rat model."	7.72	Protective effect of glycine in mesenteric ischemia and reperfusion injury in a rat model. ( Ascher, E; Gade, P; Hingorani, A; Jacob, T; Kallakuri, S; Mehraein, K; Pagala, M; Scheinman, M, 2003)
"Glycine attenuates ischemia/reperfusion injury after cold preservation by reducing oxidative damage and suppressing apoptosis independent of TNF-alpha in this model."	7.72	Glycine ameliorates lung reperfusion injury after cold preservation in an ex vivo rat lung model. ( Fukuse, T; Hasegawa, S; Ikeyama, K; Mizutani, Y; Omasa, M; Toyokuni, S; Wada, H; Yoshida, H, 2003)
"Glycine (GLY) is a neutral amino acid that has been shown to be cytoprotective in the kidneys of dogs and rabbits undergoing ischemia-reperfusion injury."	7.71	Glycine preserves function and decreases necrosis in skeletal muscle undergoing ischemia and reperfusion injury. ( Ascher, E; Cheng, W; Hanson, JN; Hingorani, A; Scheinman, M, 2001)
" Ouabain and monensin mimicked reperfusion injury and their toxicity was also reduced by taurine."	7.69	Protective effect of taurine against reperfusion injury in cultured rat astrocytes. ( Azuma, J; Baba, A; Kishida, Y; Matsuda, T; Takuma, K, 1996)
"This study investigated the effects of glycine on reperfusion injury in a low-flow, reflow liver perfusion model."	7.69	Glycine minimizes reperfusion injury in a low-flow, reflow liver perfusion model in the rat. ( Jones, S; Thurman, RG; Zhong, Z, 1996)
"We investigated the relationships among N-methyl-D-aspartate, glycine, L-type voltage-dependent calcium channels, and [3H]dopamine release in a canine model of global cerebral ischemia/reperfusion."	7.69	Increased activation of L-type voltage-dependent calcium channels is associated with glycine enhancement of N-methyl-D-aspartate-stimulated dopamine release in global cerebral ischemia/reperfusion. ( Blanck, TJ; Fiskum, G; Fox, LG; Hoehner, PJ; Hurt, KJ; Rosenthal, RE; Werling, LL, 1994)
"The objective of this investigation was to test the effects of glycine, a cytoprotectant in normothermic in vitro models of renal ischemia, in a model of hypothermic renal preservation injury."	7.68	Protective effects of glycine during hypothermic renal ischemia-reperfusion injury. ( Anderson, CB; Grabau, GG; Mangino, MJ; Murphy, MK, 1991)
"Glycine is a non-essential amino acid which is cheap, easily available and relatively non-toxic."	6.43	The role of glycine in hepatic ischemia-reperfusion injury. ( Davidson, BR; Habib, MM; Hodgson, HJ, 2006)
"Kupffer cell-dependent reperfusion injury occurs to the liver following transplantation, most often in fatty livers which fail most frequently due to primary nonfunction."	6.40	Kupffer cell-dependent reperfusion injury in liver transplantation: new clinically relevant use of glycine. ( Bunzendahl, H; Lemasters, JJ; Schemmer, P; Thurman, RG; von Frankenberg, M; Zhong, Z, 1998)
"Glycine has been shown to ameliorate IRI in various animal models."	5.48	Glycine Protects the Liver from Reperfusion Injury following Pneumoperitoneum. ( Al-Saeedi, M; Flechtenmacher, C; Gutt, CN; Liang, R; Nickkholgh, A; Schemmer, P; Schultze, D; Zorn, M, 2018)
"Glycine is a cytoprotector to protect cells against ischemic damage by counteracting neuronal depolarization."	5.38	Glycine attenuates cerebral ischemia/reperfusion injury by inhibiting neuronal apoptosis in mice. ( Bai, H; Ben, J; Chen, Q; Li, K; Li, X; Lu, Y; Ma, B; Yang, Q; Zhang, J; Zhu, X, 2012)
"Sivelestat treatment lowered the MDA concentration and the percentage of apoptotic cells bilaterally and ameliorated the testicular histological pattern bilaterally."	5.37	Protective effect of sivelestat, a neutrophil elastase inhibitor, on ipsilateral and contralateral testes after unilateral testicular ischaemia-reperfusion injury in rats. ( Dimitriadis, F; Kinoshita, Y; Saito, M; Satoh, I; Satoh, K; Shimizu, S; Shomori, K; Tsounapi, P, 2011)
"Glycine was intravenously infused for 30 min before ischemia (pre-ischemic infusion), and once again from 30 min before until 60 min after reperfusion."	5.37	Protection from glycine at low doses in ischemia-reperfusion injury of the rat small intestine. ( Boengler, K; de Groot, H; Drowatzky, J; Finckh, B; Petrat, F; Schmitz, KJ; Schulz, R, 2011)
"Also glycine-treated grafts exhibited significantly less infiltration with ED-1-positive macrophages and MPO-positive neutrophils as well as reduced apoptosis."	5.35	Perioperative glycine treatment attenuates ischemia/reperfusion injury and ameliorates smooth muscle dysfunction in intestinal transplantation. ( Abu-Elmagd, KM; Hirner, A; Kalff, JC; Overhaus, M; Schaefer, N; Schmidt, J; Schuchtrup, S; Tahara, K; Türler, A; Websky, MV; Wirz, S, 2008)
"Glycine (5% in water) was orally administered to rats for 3 days as drinking water before the surgery."	5.35	Effect of non-essential amino acid glycine administration on the liver regeneration of partially hepatectomized rats with hepatic ischemia/reperfusion injury. ( Arii, S; Horikawa, S; Ito, K; Koike, Y; Noda, Y; Ozasa, H, 2008)
"Pretreatment with glycine also significantly reduced hepatic necrosis and the number of neutrophils at 24 h after reperfusion."	5.34	Glycine reduces hepatic warm ischaemia-reperfusion injury by suppressing inflammatory reactions in rats. ( Eguchi, S; Kamohara, Y; Kanematsu, T; Okudaira, S; Tajima, Y; Yamanouchi, K; Yanaga, K, 2007)
"In glycine-treated animals, the middle and distal segments of the small intestine were well- preserved and showed better histologic grade and morphometric parameters as compared with saline controls (P<."	5.32	Glycine prevents the induction of apoptosis attributed to mesenteric ischemia/reperfusion injury in a rat model. ( Ascher, E; Hingorani, A; Jacob, T; Kallakuri, S, 2003)
"Coronary thrombosis was produced by insertion of a thrombogenic copper coil into the LAD of 40 anesthetized pigs."	5.30	Coronary thrombosis/thrombolysis in pigs: effects of heparin, ASA, and the thrombin inhibitor inogatran. ( Hatori, N; Mattsson, C; Nordlander, R; Rydén, L; Sjöquist, PO; Uriuda, Y; Wang, QD, 1998)
"Glycine protects against shock caused by hemorrhage, endotoxin and sepsis, prevents ischemia/reperfusion and cold storage/reperfusion injury to a variety of tissues and organs including liver, kidney, heart, intestine and skeletal muscle, and diminishes liver and renal injury caused by hepatic and renal toxicants and drugs."	4.82	L-Glycine: a novel antiinflammatory, immunomodulatory, and cytoprotective agent. ( Bradford, B; Bunzendaul, H; Froh, M; Lemasters, JJ; Li, X; Schemmer, P; Wheeler, MD; Yin, M; Zhong, Z, 2003)
"Donor preconditioning with glycine prevents Kupffer cell-dependent reperfusion injury to liver grafts."	3.91	Glycine protects partial liver grafts from Kupffer cell-dependent ischemia-reperfusion injury without negative effect on regeneration. ( Al-Saeedi, M; Herr, I; Liang, R; Nickkholgh, A; Schemmer, P; Schultze, DP; Zorn, M, 2019)
" To determine the role of non-ionotropic activity of NMDARs in clinical relevant conditions, we tested the effect of glycine, a co-agonist of NMDARs, in rat middle cerebral artery occlusion (MCAO), an animal model of cerebral ischemia-reperfusion injury after the animals were injected with the NMDAR channel blocker MK-801 and the glycine receptor antagonist strychnine."	3.85	A non-ionotropic activity of NMDA receptors contributes to glycine-induced neuroprotection in cerebral ischemia-reperfusion injury. ( Chen, J; Feng, H; Hu, R; Jin, P; Lei, R; Liao, H; Wan, Q; Wan, Y; Zhang, Y; Zhang, Z; Zhuang, Y, 2017)
" Therefore, we investigated whether glycine, sodium pyruvate, and resveratrol can either support or potentially harm regeneration when applied therapeutically after reperfusion injury."	3.85	Effect of Glycine, Pyruvate, and Resveratrol on the Regeneration Process of Postischemic Intestinal Mucosa. ( Brencher, L; Hamburger, T; Kirsch, M; Petrat, F; Stych, K, 2017)
" In previous study, we linked the anti-inflammatory amino acid glycine to nitronyl nitroxide and developed a novel glycine-nitronyl nitroxide (GNN) conjugate, which showed a synergetic protection against renal ischemia/reperfusion injury."	3.85	Glycine-nitronyl nitroxide conjugate protects human umbilical vein endothelial cells against hypoxia/reoxygenation injury via multiple mechanisms and ameliorates hind limb ischemia/reperfusion injury in rats. ( Bi, W; Bi, Y; Chi, K; Gao, X; Li, X; Liu, Y; Yuan, T, 2017)
"The present study was designed to investigate the role of glycine in ischemia reperfusion-induced acute kidney injury (AKI) in rats."	3.80	Glycine aggravates ischemia reperfusion-induced acute kidney injury through N-Methyl-D-Aspartate receptor activation in rats. ( Arora, S; Kaur, A; Kaur, T; Singh, AP, 2014)
"Sivelestat sodium hydrate (sivelestat) is a specific neutrophil elastase inhibitor that is effective in treating acute lung injury associated with systemic inflammatory response syndrome."	3.80	Sivelestat sodium hydrate inhibits neutrophil migration to the vessel wall and suppresses hepatic ischemia-reperfusion injury. ( Fujimura, T; Fushida, S; Hayashi, H; Kitagawa, H; Makino, I; Miyashita, T; Munesue, S; Nakagawara, H; Nakanuma, S; Ohta, T; Saito, H; Sakai, S; Tajima, H; Yamamoto, Y, 2014)
"Glycine is well known to protect the intestine against ischemia-reperfusion injury and during mechanical manipulation."	3.80	Glycine selectively reduces intestinal injury during endotoxemia. ( de Groot, H; Effenberger-Neidnicht, K; Jägers, J; Verhaegh, R, 2014)
"Neuroprotective properties of the new derivative of glutamic and apovincaminic acids, ethyl -(3-alpha,16-alpha)-eburnamenin-14-carbopxylate of 2-aminopentadionic acid (LHT 1-02) were studied on a model of acute brain ischemia in cats."	3.80	[Effect of a new derivative of glutamic and apovincaminic acids on brain metabolism in post-ischemic period]. ( Makarova, LM; Mirzoian, RS; Pogorelyĭ, VE; Prikhod'ko, MA; Skachilova, SIa, 2014)
" Although a number of studies have investigated that ginkgolide B, a purified terpene lactone component extracted from Ginkgo biloba leaves, is available "platelet activating factor (PAF) receptors antagonist", "antioxidant" with a variety of actions, very little has been performed to explore the effect of ginkgolide B on extracellular amino acids in experimental animal of focal cerebral ischemia/reperfusion."	3.77	Effect of ginkgolide B on striatal extracellular amino acids in middle cerebral artery occluded rats. ( Feng, W; Li, J; Li, SX; Wang, H; Yang, ZZ, 2011)
"This study shows that preconditioning with taurine or glycine is equally effective in preventing injury to fatty livers most likely via Kupffer cell-dependent mechanisms."	3.77	Glycine and taurine equally prevent fatty livers from Kupffer cell-dependent injury: an in vivo microscopy study. ( Bruns, H; Büchler, MW; Flechtenmacher, C; Galli, U; Gebhard, MM; Schemmer, P; Schulze-Bergkamen, H; Watanpour, I; Zorn, M, 2011)
": A neutrophil elastase (NE) inhibitor, Sivelestat, has been approved for the treatment of acute lung injury associated with systemic inflammation in humans."	3.76	The protective function of neutrophil elastase inhibitor in liver ischemia/reperfusion injury. ( Busuttil, RW; Freitas, MC; Kupiec-Weglinski, JW; Uchida, Y; Zhao, D, 2010)
" Glycine is an effective anti-inflammatory, cytoprotective agent and is reported to have a beneficial effect against ischemia/reperfusion injury in various organs."	3.75	Renal ischemia/reperfusion injury in rats is attenuated by a synthetic glycine derivative. ( Baudy-Floc'h, M; Bi, L; Bi, W; Bi, Y; Gao, X; Li, M; Liu, S; Ngerebara, N; Robinson, SC; Wang, F; Wang, T; Wang, Z; Xue, P; Zhang, Y, 2009)
" In the present study, we investigated the effect of sivelestat, a neutrophil elastase inhibitor, on reperfusion injury of a donor lung that was harvested from endotoxin-primed animals in a rat lung transplantation model."	3.74	Sivelestat reduces reperfusion injury of lungs harvested from endotoxin-primed rats by inhibition of neutrophil-mediated inflammation. ( Kondo, T; Niikawa, H; Oishi, H; Sugawara, T; Suzuki, S; Tabata, T, 2007)
"Addition of sivelestat to the organ flushing solution ameliorated ischemia-reperfusion injury in a lung transplant model."	3.74	Addition of a neutrophil elastase inhibitor to the organ flushing solution decreases lung reperfusion injury in rat lung transplantation. ( Date, H; Kotani, K; Mori, H; Nagahiro, I; Nakanishi, H; Osaragi, T; Sano, Y; Shimizu, N, 2007)
"In the present study, we evaluated the effect of neutrophil elastase inhibitor, sivelestat sodium hydrate on ischemia-reperfusion injury in the rat bladder."	3.74	Neutrophil elastase inhibitor, sivelestat sodium hydrate prevents ischemia-reperfusion injury in the rat bladder. ( Kono, T; Okada, S; Saito, M, 2008)
"The effect of Sivelestat, a neutrophil elastase inhibitor, on hepatic ischemia-reperfusion injury was examined in a pig hepatectomy model."	3.74	Protective effect of Sivelestat in a porcine hepatectomy model prepared using an intermittent Pringle method. ( Iwasaki, Y; Kubota, K; Okada, T; Sawada, T; Shimoda, M, 2008)
" Glycine, a non-toxic, non-essential amino acid has been conclusively shown in various experiments to prevent both activation of Kupffer cells and reperfusion injury."	3.73	HEGPOL: randomized, placebo controlled, multicenter, double-blind clinical trial to investigate hepatoprotective effects of glycine in the postoperative phase of liver transplantation [ISRCTN69350312]. ( Büchler, MW; Bunzendahl, H; Klar, E; Kraus, TW; Luntz, SP; Schemmer, P; Seibert-Grafe, M; Unnebrink, K, 2005)
"Glycine could efficiently protect rat liver grafts from ischemia-reperfusion injury by repressing the expression of CD14 and NF-kappa B binding activity in Kupffer cells and inhibiting the productions of TNF alpha and IL-1."	3.73	[The effect of glycine on CD14 and NF-kappa B in Kupffer cells from rat liver grafts after ischemia-reperfusion injury]. ( Gan, L; Gong, JP; Li, SB; Li, SW; Liu, CA; Peng, Y, 2005)
"Alpha-lipoic (LA) acid pretreatment has previously been described to reduce ischemia/reperfusion injury (IRI) after warm liver ischemia, whereas glycine pretreatment has been shown to be protective mostly in models of cold hepatic ischemia."	3.73	Different protection mechanisms after pretreatment with glycine or alpha-lipoic acid in a rat model of warm hepatic ischemia. ( Duenschede, F; Dutkowski, P; Erbes, K; Ewald, P; Junginger, T; Kiemer, AK; Kircher, A; Miesner, I; Riegler, N; Schad, A; Schaefer, H; Schneider, J; Westermann, S, 2006)
"Glycine reduces ischemia-reperfusion injury after experimental liver transplantation."	3.73	Glycine application and right heart function in a porcine heart transplantation model. ( Haverich, A; Klima, U; Schulze, B; Steinkamp, T; Warnecke, G, 2006)
"The potential role of glycine in combination with standard lung preservation with low-potassium dextran solution in lung ischemia-reperfusion injury has not been investigated in a preclinical porcine transplant model."	3.73	Glycine intravenous donor preconditioning is superior to glycine supplementation to low-potassium dextran flush preservation and improves graft function in a large animal lung transplantation model after 24 hours of cold ischemia. ( Avsar, M; Fischer, S; Gohrbandt, B; Haverich, A; Sommer, SP; Strueber, M; Warnecke, G, 2006)
"To determine whether glycine could downregulate interleukin 1 receptor associated kinase-4 (IRAK-4) expression to interfere with lipopolysaccharides (LPS) signal transduction and blunt transplantative liver ischemia-reperfusion injury (I/RI)."	3.73	Glycine blunts transplantative liver ischemia-reperfusion injury by downregulating interleukin 1 receptor associated kinase-4. ( Gong, JP; Li, SW; Liu, ZJ; Yan, LN; You, HB, 2006)
"Glycine improved mucosal viability in the ischemia and reperfusion injury rat model."	3.72	Protective effect of glycine in mesenteric ischemia and reperfusion injury in a rat model. ( Ascher, E; Gade, P; Hingorani, A; Jacob, T; Kallakuri, S; Mehraein, K; Pagala, M; Scheinman, M, 2003)
"Glycine attenuates ischemia/reperfusion injury after cold preservation by reducing oxidative damage and suppressing apoptosis independent of TNF-alpha in this model."	3.72	Glycine ameliorates lung reperfusion injury after cold preservation in an ex vivo rat lung model. ( Fukuse, T; Hasegawa, S; Ikeyama, K; Mizutani, Y; Omasa, M; Toyokuni, S; Wada, H; Yoshida, H, 2003)
"Glycine (GLY) is a neutral amino acid that has been shown to be cytoprotective in the kidneys of dogs and rabbits undergoing ischemia-reperfusion injury."	3.71	Glycine preserves function and decreases necrosis in skeletal muscle undergoing ischemia and reperfusion injury. ( Ascher, E; Cheng, W; Hanson, JN; Hingorani, A; Scheinman, M, 2001)
"This study investigated the effects of glycine on reperfusion injury in a low-flow, reflow liver perfusion model."	3.69	Glycine minimizes reperfusion injury in a low-flow, reflow liver perfusion model in the rat. ( Jones, S; Thurman, RG; Zhong, Z, 1996)
"We investigated the relationships among N-methyl-D-aspartate, glycine, L-type voltage-dependent calcium channels, and [3H]dopamine release in a canine model of global cerebral ischemia/reperfusion."	3.69	Increased activation of L-type voltage-dependent calcium channels is associated with glycine enhancement of N-methyl-D-aspartate-stimulated dopamine release in global cerebral ischemia/reperfusion. ( Blanck, TJ; Fiskum, G; Fox, LG; Hoehner, PJ; Hurt, KJ; Rosenthal, RE; Werling, LL, 1994)
" Ouabain and monensin mimicked reperfusion injury and their toxicity was also reduced by taurine."	3.69	Protective effect of taurine against reperfusion injury in cultured rat astrocytes. ( Azuma, J; Baba, A; Kishida, Y; Matsuda, T; Takuma, K, 1996)
"The objective of this investigation was to test the effects of glycine, a cytoprotectant in normothermic in vitro models of renal ischemia, in a model of hypothermic renal preservation injury."	3.68	Protective effects of glycine during hypothermic renal ischemia-reperfusion injury. ( Anderson, CB; Grabau, GG; Mangino, MJ; Murphy, MK, 1991)
"Glycine is a non-essential amino acid which is cheap, easily available and relatively non-toxic."	2.43	The role of glycine in hepatic ischemia-reperfusion injury. ( Davidson, BR; Habib, MM; Hodgson, HJ, 2006)
"Kupffer cell-dependent reperfusion injury occurs to the liver following transplantation, most often in fatty livers which fail most frequently due to primary nonfunction."	2.40	Kupffer cell-dependent reperfusion injury in liver transplantation: new clinically relevant use of glycine. ( Bunzendahl, H; Lemasters, JJ; Schemmer, P; Thurman, RG; von Frankenberg, M; Zhong, Z, 1998)
"Glycine has been well characterized in spinal cord as an inhibitory neurotransmitter which activates a glycine-gated chloride channel (GlyR) expressed in postsynaptic membranes."	2.40	Glycine: a new anti-inflammatory immunonutrient. ( Bradford, B; Enomoto, N; Ikejema, K; Rose, ML; Rusyn, I; Schemmer, P; Seabra, V; Stacklewitz, RF; Thurman, RG; Wheeler, MD; Yin, M; Zhong, Z, 1999)
"Glycine was added to the flush solution, the perfusate, and the perfusion circuit."	1.51	Improvement of Normothermic Ex Vivo Machine Perfusion of Rat Liver Grafts by Dialysis and Kupffer Cell Inhibition With Glycine. ( Arsenic, R; Claussen, F; Gassner, JMGV; Horner, R; Moosburner, S; Nösser, M; Pratschke, J; Raschzok, N; Sauer, IM; Tang, P; Wegener, L; Wyrwal, D, 2019)
"Glycine has been shown to ameliorate IRI in various animal models."	1.48	Glycine Protects the Liver from Reperfusion Injury following Pneumoperitoneum. ( Al-Saeedi, M; Flechtenmacher, C; Gutt, CN; Liang, R; Nickkholgh, A; Schemmer, P; Schultze, D; Zorn, M, 2018)
"Treatment with sivelestat significantly improved survival rate with P = 0."	1.39	Sivelestat improves outcome of crush injury by inhibiting high-mobility group box 1 in rats. ( Abe, C; Binh, NH; Cuong, NT; Hara, A; Morita, H; Ogura, S, 2013)
"Bowel ischemia reperfusion injury (IRI) induced by supravisceral aortic clamping is associated with an excessive systemic inflammatory response, resulting in remote organ damage, including ALI."	1.39	Neutrophil elastase inhibitor improves survival rate after ischemia reperfusion injury caused by supravisceral aortic clamping in rats. ( Du, W; Fujimura, N; Itano, O; Kawasako, K; Kitagawa, Y; Kitago, M; Maruyama, I; Matsuda, S; Matsumoto, K; Miyasho, T; Obara, H; Ono, S; Sakamoto, M; Shinoda, M; Suda, K; Takeuchi, H; Tanabe, M; Yagi, H; Yamada, S, 2013)
"Glycine is a cytoprotector to protect cells against ischemic damage by counteracting neuronal depolarization."	1.38	Glycine attenuates cerebral ischemia/reperfusion injury by inhibiting neuronal apoptosis in mice. ( Bai, H; Ben, J; Chen, Q; Li, K; Li, X; Lu, Y; Ma, B; Yang, Q; Zhang, J; Zhu, X, 2012)
"Sivelestat treatment lowered the MDA concentration and the percentage of apoptotic cells bilaterally and ameliorated the testicular histological pattern bilaterally."	1.37	Protective effect of sivelestat, a neutrophil elastase inhibitor, on ipsilateral and contralateral testes after unilateral testicular ischaemia-reperfusion injury in rats. ( Dimitriadis, F; Kinoshita, Y; Saito, M; Satoh, I; Satoh, K; Shimizu, S; Shomori, K; Tsounapi, P, 2011)
"Glycine was intravenously infused for 30 min before ischemia (pre-ischemic infusion), and once again from 30 min before until 60 min after reperfusion."	1.37	Protection from glycine at low doses in ischemia-reperfusion injury of the rat small intestine. ( Boengler, K; de Groot, H; Drowatzky, J; Finckh, B; Petrat, F; Schmitz, KJ; Schulz, R, 2011)
"In conclusion, focal cerebral ischemia and reperfusion impaired vasoconstrictor responses in remote brain arteries of rats by a mechanism involving free radicals."	1.36	Decreased vasoconstrictor responses in remote cerebral arteries after focal brain ischemia and reperfusion in the rat, in vitro. ( Albert, M; Benedek, A; Hársing, LG; Kovács, A; Móricz, K; Szénási, G, 2010)
"Glycine (5% in water) was orally administered to rats for 3 days as drinking water before the surgery."	1.35	Effect of non-essential amino acid glycine administration on the liver regeneration of partially hepatectomized rats with hepatic ischemia/reperfusion injury. ( Arii, S; Horikawa, S; Ito, K; Koike, Y; Noda, Y; Ozasa, H, 2008)
"Also glycine-treated grafts exhibited significantly less infiltration with ED-1-positive macrophages and MPO-positive neutrophils as well as reduced apoptosis."	1.35	Perioperative glycine treatment attenuates ischemia/reperfusion injury and ameliorates smooth muscle dysfunction in intestinal transplantation. ( Abu-Elmagd, KM; Hirner, A; Kalff, JC; Overhaus, M; Schaefer, N; Schmidt, J; Schuchtrup, S; Tahara, K; Türler, A; Websky, MV; Wirz, S, 2008)
" In porcine NHBD-LTx, we previously reported a 50% risk of PNF and toxic bile formation in grafts exposed to > or =30' warm ischemia (WI)."	1.35	Multifactorial biological modulation of warm ischemia reperfusion injury in liver transplantation from non-heart-beating donors eliminates primary nonfunction and reduces bile salt toxicity. ( Balligand, E; Buurman, W; Deckx, H; Derveaux, K; Heedfeld, V; Hoekstra, H; Libbrecht, L; Liu, Q; Monbaliu, D; Parkkinen, J; Pirenne, J; Porte, RJ; Vaahtera, L; van Pelt, J; Vekemans, K; Wylin, T; Zeegers, M, 2009)
"Ischemia/reperfusion injury is mediated by various mechanisms."	1.35	Fundamental efforts toward the development of a therapeutic cocktail with a manifold ameliorative effect on hepatic ischemia/reperfusion injury. ( Backhaus, J; Büchler, MW; Flechtenmacher, C; Gebhard, MM; Kincius, M; Liang, R; Schemmer, P; Schindler, G; Zorn, M, 2009)
"Pretreatment with glycine also significantly reduced hepatic necrosis and the number of neutrophils at 24 h after reperfusion."	1.34	Glycine reduces hepatic warm ischaemia-reperfusion injury by suppressing inflammatory reactions in rats. ( Eguchi, S; Kamohara, Y; Kanematsu, T; Okudaira, S; Tajima, Y; Yamanouchi, K; Yanaga, K, 2007)
"In glycine-treated animals, the middle and distal segments of the small intestine were well- preserved and showed better histologic grade and morphometric parameters as compared with saline controls (P<."	1.32	Glycine prevents the induction of apoptosis attributed to mesenteric ischemia/reperfusion injury in a rat model. ( Ascher, E; Hingorani, A; Jacob, T; Kallakuri, S, 2003)
"Ischemia-reperfusion injury is a significant problem in lung transplantation."	1.32	The effects of a specific neutrophil elastase inhibitor (ONO-5046) in pulmonary ischemia-reperfusion injury. ( Ishikawa, N; Kawaguchi, M; Oda, M; Tsunezuka, Y; Watanabe, G, 2003)
"Perhexiline is a potent prophylactic anti-anginal agent that has been shown to inhibit myocardial utilization of long-chain fatty acids and to inhibit the mitochondrial enzyme carnitine palmitoyltransferase (CPT)-1."	1.31	Effect of perhexiline and oxfenicine on myocardial function and metabolism during low-flow ischemia/reperfusion in the isolated rat heart. ( Horowitz, JD; Kennedy, JA; Kiosoglous, AJ; Murphy, GA; Pelle, MA, 2000)
"Ischemia/reperfusion injury is a major cause of transplanted heart dysfunction."	1.31	Effect of a neutrophil elastase inhibitor (ONO-5046 Na) on ischemia/reperfusion injury using the left-sided heterotopic canine heart transplantation model. ( Fukumoto, Y; Moriyama, Y; Nakamura, K; Sakasegawa, K; Sakata, R; Toda, R; Ueno, M; Yamamoto, H; Yotsumoto, G, 2001)
"This pH-dependent reperfusion injury (pH paradox) was prevented after KCN washout at pH 6."	1.30	Mitochondrial dysfunction and cytoskeletal disruption during chemical hypoxia to cultured rat hepatic sinusoidal endothelial cells: the pH paradox and cytoprotection by glucose, acidotic pH, and glycine. ( Lemasters, JJ; Nishimura, Y; Romer, LH, 1998)
"Coronary thrombosis was produced by insertion of a thrombogenic copper coil into the LAD of 40 anesthetized pigs."	1.30	Coronary thrombosis/thrombolysis in pigs: effects of heparin, ASA, and the thrombin inhibitor inogatran. ( Hatori, N; Mattsson, C; Nordlander, R; Rydén, L; Sjöquist, PO; Uriuda, Y; Wang, QD, 1998)
"Glycine has been shown to decrease membrane injury in isolated cells due to hypoxia or cold ischemia."	1.29	Effect of glycine on isolated, perfused rabbit livers following 48-hour preservation in University of Wisconsin solution without glutathione. ( Belzer, FO; den Butter, G; Lindell, SL; Marsh, DC; Southard, JH, 1994)

Research

Studies (139)

Authors

Clinical Trials (6)

Trial Overview

Trial Outcomes

Changes in Serum Concentration of Inflammatory Biomarkers (TNF-alpha)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	35 (25.18)	18.2507
2000's	57 (41.01)	29.6817
2010's	42 (30.22)	24.3611
2020's	5 (3.60)	2.80

Authors	Studies
Zhang, M	2
Dong, R	1
Yuan, J	1
Da, J	1
Zha, Y	1
Long, Y	1
Gan, Z	1
Xie, D	1
Wu, X	1
Hong, C	1
Fu, J	1
Fan, L	1
Wang, S	1
Han, S	1
Mohr, A	1
Brockmann, JG	1
Becker, F	1
Eleftheriadis, T	1
Pissas, G	1
Filippidis, G	1
Liakopoulos, V	1
Stefanidis, I	1
Wu, M	1
Chen, W	1
Miao, M	1
Jin, Q	1
Zhang, S	1
Bai, M	1
Fan, J	1
Zhang, Y	5
Zhang, A	1
Jia, Z	1
Huang, S	1
Gao, X	2
Bi, Y	2
Chi, K	1
Liu, Y	2
Yuan, T	1
Li, X	4
Bi, W	2
Chen, J	1
Hu, R	1
Liao, H	1
Lei, R	1
Zhang, Z	1
Zhuang, Y	1
Wan, Y	1
Jin, P	1
Feng, H	1
Wan, Q	1
Brencher, L	1
Petrat, F	3
Stych, K	1
Hamburger, T	1
Kirsch, M	1
Lautenschläger, I	1
Pless-Petig, G	1
Middel, P	1
de Groot, H	4
Rauen, U	1
Stojanovic, T	1
Al-Saeedi, M	2
Nickkholgh, A	2
Schultze, D	1
Flechtenmacher, C	3
Zorn, M	4
Liang, R	3
Gutt, CN	1
Schemmer, P	13
Gassner, JMGV	1
Nösser, M	1
Moosburner, S	1
Horner, R	1
Tang, P	1
Wegener, L	1
Wyrwal, D	1
Claussen, F	1
Arsenic, R	1
Pratschke, J	1
Sauer, IM	1
Raschzok, N	1
Schultze, DP	1
Herr, I	1
Issa, K	1
Kimmoun, A	1
Collin, S	1
Ganster, F	1
Fremont-Orlowski, S	1
Asfar, P	1
Mertes, PM	1
Levy, B	1
Sakai, S	1
Tajima, H	1
Miyashita, T	1
Nakanuma, S	1
Makino, I	1
Hayashi, H	1
Nakagawara, H	1
Kitagawa, H	1
Fushida, S	1
Fujimura, T	1
Saito, H	1
Munesue, S	1
Yamamoto, Y	1
Ohta, T	1
Arora, S	1
Kaur, T	1
Kaur, A	1
Singh, AP	1
Chen, X	2
Li, H	1
Huang, M	2
Xu, W	1
Chu, K	1
Chen, L	1
Makarova, LM	1
Prikhod'ko, MA	1
Pogorelyĭ, VE	1
Skachilova, SIa	1
Mirzoian, RS	1
Effenberger-Neidnicht, K	1
Jägers, J	1
Verhaegh, R	1
Wang, Y	2
Wang, YG	1
Ma, TF	1
Li, M	2
Gu, SL	1
Andringa, KK	1
Agarwal, A	1
Han, SJ	1
Kim, JI	1
Park, JW	1
Park, KM	1
Cai, S	1
Ichimaru, N	1
Zhao, M	1
Fujino, M	1
Ito, H	1
Ota, U	1
Nakajima, M	1
Tanaka, T	2
Nonomura, N	1
Li, XK	1
Takahara, S	1
Ito, K	1
Ozasa, H	2
Noda, Y	1
Koike, Y	1
Arii, S	1
Horikawa, S	1
Barba, I	1
Chavarria, L	1
Ruiz-Meana, M	1
Mirabet, M	1
Agulló, E	1
Garcia-Dorado, D	1
Nakano, Y	2
Kondo, T	3
Matsuo, R	1
Murata, S	2
Fukunaga, K	2
Ohkohchi, N	2
García-Criado, FJ	1
Rodriguez-Barca, P	1
García-Cenador, MB	1
Rivas-Elena, JV	1
Grande, MT	1
Lopez-Marcos, JF	1
Mourelle, M	1
López-Novoa, JM	1
Wang, F	1
Wang, T	1
Xue, P	1
Liu, S	1
Wang, Z	1
Baudy-Floc'h, M	1
Robinson, SC	1
Ngerebara, N	1
Bi, L	1
Schindler, G	1
Kincius, M	1
Backhaus, J	1
Gebhard, MM	2
Büchler, MW	5
Monbaliu, D	1
Vekemans, K	1
Hoekstra, H	1
Vaahtera, L	1
Libbrecht, L	1
Derveaux, K	1
Parkkinen, J	1
Liu, Q	1
Heedfeld, V	1
Wylin, T	1
Deckx, H	1
Zeegers, M	1
Balligand, E	1
Buurman, W	1
van Pelt, J	1
Porte, RJ	1
Pirenne, J	1
Tseng, EE	1
Brock, MV	1
Lange, MS	1
Troncoso, JC	1
Blue, ME	1
Lowenstein, CJ	1
Johnston, MV	1
Baumgartner, WA	1
Uchida, Y	1
Freitas, MC	1
Zhao, D	1
Busuttil, RW	1
Kupiec-Weglinski, JW	1
Pak, S	1
Oda, T	1
Sasaki, R	1
Qiu, W	1
Wei, R	1
Zhang, C	2
Leng, W	1
Wang, W	1
Kawai, M	1
Harada, N	3
Takeyama, H	1
Okajima, K	3
Tsounapi, P	1
Saito, M	2
Dimitriadis, F	1
Shimizu, S	1
Kinoshita, Y	1
Shomori, K	1
Satoh, I	1
Satoh, K	1
Kovács, A	1
Móricz, K	1
Albert, M	1
Benedek, A	1
Hársing, LG	1
Szénási, G	1
Wang, YS	1
Yan, YH	1
Zou, XF	1
Hoffmann, K	1
Sheth, H	1
Hafez, T	1
Glantzounis, GK	1
Seifalian, AM	1
Fuller, B	1
Davidson, BR	2
Bruns, H	1
Watanpour, I	1
Galli, U	1
Schulze-Bergkamen, H	1
Hart, ML	1
Grenz, A	1
Gorzolla, IC	1
Schittenhelm, J	1
Dalton, JH	1
Eltzschig, HK	1
Drowatzky, J	1
Boengler, K	2
Finckh, B	1
Schmitz, KJ	1
Schulz, R	2
Yang, ZZ	1
Li, J	1
Li, SX	1
Feng, W	1
Wang, H	1
Petrov, VI	1
Ponomarev, ÉA	1
Maskin, SS	1
Strepetov, NN	1
Mard, SA	1
Neisi, N	1
Solgi, G	1
Hassanpour, M	1
Darbor, M	1
Maleki, M	1
Sommer, SP	2
Sommer, S	1
Sinha, B	1
Leyh, RG	1
Tsujii, S	1
Okabayashi, T	1
Shiga, M	1
Takezaki, Y	1
Sugimoto, T	1
Kobayashi, M	1
Hanazaki, K	1
Fujimura, N	1
Obara, H	1
Suda, K	1
Takeuchi, H	1
Miyasho, T	1
Kawasako, K	1
Du, W	1
Yamada, S	2
Ono, S	1
Matsumoto, K	1
Matsuda, S	1
Yagi, H	1
Kitago, M	1
Shinoda, M	1
Itano, O	1
Tanabe, M	1
Sakamoto, M	1
Maruyama, I	1
Kitagawa, Y	1
Bhagatte, Y	1
Lodwick, D	1
Storey, N	1
Lu, Y	1
Zhang, J	1
Ma, B	1
Li, K	1
Bai, H	1
Yang, Q	1
Zhu, X	2
Ben, J	1
Chen, Q	1
Jamadarkhana, P	1
Chaudhary, A	1
Chhipa, L	1
Dubey, A	1
Mohanan, A	1
Gupta, R	1
Deshpande, S	1
Wu, J	1
Wei, J	1
You, X	1
Zhu, H	1
Xu, M	1
Cuong, NT	1
Abe, C	1
Binh, NH	1
Hara, A	1
Morita, H	1
Ogura, S	1
Golling, M	1
Kraus, T	2
Mehrabi, A	2
Mayatepek, E	1
Herfarth, Ch	1
Klar, E	2
Rentsch, M	2
Beham, A	2
Sirek, S	2
Iesalnieks, I	2
Geissler, EK	1
Anthuber, M	1
Jauch, KW	2
Zakaria, FA	1
Doi, K	1
Horiuchi, T	1
Uchinami, M	1
Tabo, T	1
Kimura, N	1
Yokomachi, J	1
Yoshida, M	2
Tanaka, K	1
Kim, JS	1
Qian, T	2
Lemasters, JJ	8
Zhong, Z	6
Wheeler, MD	2
Froh, M	1
Yin, M	4
Bunzendaul, H	1
Bradford, B	2
Toufektsian, MC	1
Morel, S	1
Tanguy, S	1
Jeunet, A	1
de Leiris, J	1
Boucher, F	1
Omasa, M	1
Fukuse, T	1
Toyokuni, S	1
Mizutani, Y	1
Yoshida, H	1
Ikeyama, K	1
Hasegawa, S	1
Wada, H	1
Ishikawa, N	1
Oda, M	1
Kawaguchi, M	1
Tsunezuka, Y	1
Watanabe, G	1
Bunzendahl, H	5
Thurman, RG	9
Jacob, T	2
Ascher, E	3
Hingorani, A	3
Kallakuri, S	2
Pagala, M	1
Gade, P	1
Scheinman, M	2
Mehraein, K	1
Sauer, P	1
Gutt, C	1
Uhl, W	1
Uchiba, M	2
Mori, M	1
Dijk, F	2
van Leeuwen, S	1
Kamphuis, W	2
Kotake, Y	1
Yamamoto, M	1
Matsumoto, M	1
Morisaki, H	1
Takeda, J	1
Peng, Y	1
Gong, JP	2
Liu, CA	1
Li, SW	2
Gan, L	1
Li, SB	1
Silva, MA	1
Richards, DA	1
Bramhall, SR	1
Adams, DH	1
Mirza, DF	1
Murphy, N	1
Puellmann, K	1
Kienle, K	1
Mueller, T	1
Bolder, U	1
Geissler, E	1
Luntz, SP	1
Unnebrink, K	1
Seibert-Grafe, M	1
Kraus, TW	1
Warnecke, G	2
Schulze, B	1
Steinkamp, T	1
Haverich, A	2
Klima, U	1
Gohrbandt, B	1
Fischer, S	1
Avsar, M	1
Strueber, M	1
Hu, X	1
Ge, QF	1
Zhang, L	1
Lu, YB	1
Wei, EQ	1
Marina Prendes, MG	1
García, JV	1
Testoni, G	1
Fernández, MA	1
Perazzo, JC	1
Savino, EA	1
Varela, A	1
Habib, MM	1
Hodgson, HJ	1
Hayama, T	1
Matsuyama, M	1
Funao, K	1
Tsuchida, K	1
Takemoto, Y	1
Kawahito, Y	1
Sano, H	1
Nakatani, T	1
Yoshimura, R	1
Duenschede, F	1
Westermann, S	1
Riegler, N	1
Miesner, I	1
Erbes, K	1
Ewald, P	1
Kircher, A	1
Schaefer, H	1
Schneider, J	1
Schad, A	1
Dutkowski, P	1
Kiemer, AK	1
Junginger, T	1
Liu, ZJ	1
Yan, LN	1
You, HB	1
White, MY	1
Tchen, AS	1
McCarron, HC	1
Hambly, BD	1
Jeremy, RW	1
Cordwell, SJ	1
Xiao, ZY	1
Sun, CK	1
Xiao, XW	1
Lin, YZ	1
Li, S	1
Ma, H	1
Song, GR	1
Cheng, R	1
Suzuki, S	1
Sugawara, T	1
Tabata, T	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Combined Drug Approach to Prevent Ischemia-reperfusion Injury During Transplantation of Livers (CAPITL): a First-in-men Study[NCT01886443]	Phase 1	10 participants (Actual)	Interventional	2013-08-31	Completed
Combined Drug Approach to Prevent Ischemia-reperfusion Injury During Transplantation of Livers (CAPITL): a First-in-men Study[NCT02251041]	Phase 2	72 participants (Actual)	Interventional	2014-09-30	Completed
The Effects of Glycine on Atherosclerosis and Metabolic Syndrome-related Parameters: A Clinical and Ex-vivo Study.[NCT03850314]	Phase 2/Phase 3	50 participants (Anticipated)	Interventional	2019-03-31	Not yet recruiting
Controlled and Randomized Clinical Trial for Evaluating the Effect of a Supplement of Glycine as Adjuvant in the Treatment of COVID-19 Pneumonia in Patients Initiating Mechanical Ventilation[NCT04443673]		59 participants (Actual)	Interventional	2020-06-15	Terminated (stopped due to An interim analysis showed no difference in major outcomes (n=35 glycine and n=24 control participants))
The Effect of Pre- and Postoperative Supplemental Enteral Nutrition in High-Risk Patients Undergoing Elective Cardiac Surgery. A Prospective Double Blind Study.[NCT00247793]		0 participants	Interventional	1996-07-31	Completed
Evaluation of the Capability of a Glycine Oral Supplement for Diminishing Bronchial Inflammation in Children With Cystic Fibrosis[NCT01417481]	Phase 2	13 participants (Actual)	Interventional	2012-03-31	Terminated (stopped due to Some of the researchers finished their participation in the study.)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

To correct for the baseline variability, all measurements were expressed as percentage of baseline (value at week 8 with respect to baseline value [beginning of the glycine or placebo period, respectively]). Then, percentages were log-transformed to adjust to a normal distribution. (NCT01417481)
Timeframe: 8 weeks

Changes in Sputum Concentration of Inflammatory Biomarkers (G-CSF)

Intervention	log (percent change) (Mean)
Glycine	-0.3908
Placebo	0.2035

To correct for the baseline variability, all measurements were expressed as percentage of baseline (value at week 8 with respect to baseline value [beginning of the glycine or placebo period, respectively]). Then, percentage change was log-transformed to adjust to a normal distribution. (NCT01417481)
Timeframe: 8 weeks

Changes in Sputum Concentration of Inflammatory Biomarkers (IL-6)

Intervention	log (percent change) (Mean)
Glycine	-0.0819
Placebo	0.1668

To correct for the baseline variability, all measurements were expressed as percentage of baseline (value at week 8 with respect to baseline value [beginning of the glycine or placebo period, respectively]). Then, percentage change was log-transformed to adjust to a normal distribution. (NCT01417481)
Timeframe: 8 weeks

Changes in Clinical Data Scores (Other Than Sputum Production, Dyspnea and Global Symptoms)

Intervention	log (percent change) (Mean)
Glycine	-0.00007
Placebo	0.1739

"To correct for the baseline variability, all measurements were expressed as percentage of baseline (value at week 8 with respect to baseline value [beginning of the glycine or placebo period, respectively]).~Each respiratory symptom (Cough severity, Sputum features, Appetite, Dyspnea, and Energy perception) was evaluated in a 5-options Likert scale, ranging from 1 (better) to 5 (worse). The total score was computed by the simple sum of the five symptoms." (NCT01417481)
Timeframe: 8 weeks

Changes in FEV1, FEF25, and FEFmax

Intervention	Percentage of baseline (Mean)
	Cough questionnaire score	Appetite questionnaire score	Energy questionnaire score	Body weight	Height	Heart rate	Respiratory rate	Temperature
Glycine	81.1	89.1	84.6	101.6	100.5	103.5	94.8	100.0
Placebo	89.1	132.1	111.5	103.6	100.5	98.1	109.0	100.1

Changes in Other Spirometric Variables

Intervention	Percentage of baseline (Mean)
	Forced expiratory volume at first second (FEV1)	Forced expiratory flow at 25%FVC (FEF25)	Maximal forced expiratory flow (FEFmax, PEFR)
Glycine	109.7	133.9	115.3
Placebo	91.4	83.3	91.2

Changes in Pulse Oximetry, FEV1/FVC, and FEF50.

Intervention	Percentage of baseline (Mean)
	Forced vital capacity (FVC)	Forced expiratory flow at 75%FVC (FEF75)
Glycine	104.1	111.8
Placebo	100.6	108.9

Changes in Score for Sputum Production, Dyspnea and Global Symptoms

Intervention	Percentage of baseline (Mean)
	Peripheral oxygen saturation (SpO2)	FEV1/FVC	Forced expiratory flow at 50%FVC (FEF50)
Glycine	105.2	105.2	115.5
Placebo	98.9	94.9	93.1

"To correct for the baseline variability, all measurements were expressed as percentage of baseline (value at week 8 with respect to baseline value [beginning of the glycine or placebo period, respectively]).~In the symptoms questionnaire, each respiratory symptom (Cough severity, Sputum features, Appetite, Dyspnea, and Energy perception) was evaluated in a 5-options Likert scale, ranging from 1 (better) to 5 (worse). The total score was computed by the simple sum of the five symptoms." (NCT01417481)
Timeframe: 8 weeks

Changes in Serum Concentration of Inflammatory Biomarkers (Other Than TNF-alpha)

Intervention	Percentage of baseline (Mean)
	Sputum questionnaire score	Dyspnea questionnaire score	Total questionnaire score
Glycine	82.0	75.6	77.7
Placebo	102.6	103.8	98.7

Changes in Sputum Concentration of Inflammatory Biomarkers (Other Than IL-6 and G-CSF)

Intervention	log (percent change) (Mean)
	Myeloperoxidase	IL-1	IL-4	IL-6	IL-7	IL-8	IL-12	IL-13	G-CSF	IFN-gamma	MCP-1	MIP-1beta
Glycine	-0.4361	-0.1635	0.2964	0.0085	0.0356	-0.1466	0.3203	-0.0561	-0.0776	0.3272	-0.0836	0.0330
Placebo	-0.2906	-0.0352	0.1470	0.2255	0.0819	-0.2364	0.2603	0.1953	0.2272	0.3639	0.0472	-0.0608

To correct for the baseline variability, all measurements were expressed as percentage of baseline (value at week 8 with respect to baseline value [beginning of the glycine or placebo period, respectively]). Then, percentage change was log-transformed to adjust to a normal distribution. (NCT01417481)
Timeframe: 8 weeks

Intervention	log (percent change) (Mean)
	Myeloperoxidase	IL-1	IL-2	IL-4	IL-5	IL-7	IL-8	IL-10	IL-12	IL-13	IL-17	IFN-gamma	MCP-1	MIP-1beta	TNF-alpha	GM-CSF
Glycine	0.1294	-0.0918	0.0233	-0.0161	0.2498	0.0611	-0.0824	0.0549	0.1675	0.1630	0.0680	0.0248	0.0042	-0.0303	0.0412	-0.0538
Placebo	0.0669	-0.0102	-0.0274	0.0522	0.1304	0.1387	0.0542	0.0074	0.0677	0.0953	0.1140	0.0649	0.2608	0.0977	0.1568	-0.0822

Article	Year
Glycinergic Signaling in Macrophages and Its Application in Macrophage-Associated Diseases. Frontiers in immunology, 2021, Volume: 12 Topics: Animals; Colitis; Glycine; Humans; Macrophages; Metabolic Diseases; MicroRNAs; Neoplasms; Reperfusio	2021
HTK-N: Modified Histidine-Tryptophan-Ketoglutarate Solution-A Promising New Tool in Solid Organ Preservation. International journal of molecular sciences, 2020, Sep-04, Volume: 21, Issue:18 Topics: Alanine; Animals; Arginine; Cryopreservation; Glucose; Glycine; Humans; Liver; Mannitol; Organ Prese	2020
Role of hypoxia-inducible factors in acute kidney injury. Nephron. Clinical practice, 2014, Volume: 127, Issue:1-4 Topics: Acetazolamide; Acute Kidney Injury; Adaptation, Physiological; Altitude; Animals; Barbiturates; Basi	2014
Protective effect of glycine on liver injury during liver transplantation. Chinese medical journal, 2010, Volume: 123, Issue:14 Topics: Glycine; Humans; Kupffer Cells; Liver; Liver Transplantation; Reperfusion Injury	2010
Supplementation of amino acids to prevent reperfusion injury after liver surgery and transplantation--where do we stand today? Clinical nutrition (Edinburgh, Scotland), 2011, Volume: 30, Issue:2 Topics: Acetylcysteine; Amino Acids; Glycine; Hepatectomy; Humans; Kupffer Cells; Liver; Liver Failure; Live	2011
Glycine, a simple physiological compound protecting by yet puzzling mechanism(s) against ischaemia-reperfusion injury: current knowledge. British journal of pharmacology, 2012, Volume: 165, Issue:7 Topics: Animals; Cell Membrane; Cells, Cultured; Glycine; Humans; In Vitro Techniques; Inflammation; Intesti	2012
Glycine, a simple physiological compound protecting by yet puzzling mechanism(s) against ischaemia-reperfusion injury: current knowledge. British journal of pharmacology, 2012, Volume: 165, Issue:7 Topics: Animals; Cell Membrane; Cells, Cultured; Glycine; Humans; In Vitro Techniques; Inflammation; Intesti	2012
Glycine, a simple physiological compound protecting by yet puzzling mechanism(s) against ischaemia-reperfusion injury: current knowledge. British journal of pharmacology, 2012, Volume: 165, Issue:7 Topics: Animals; Cell Membrane; Cells, Cultured; Glycine; Humans; In Vitro Techniques; Inflammation; Intesti	2012
Glycine, a simple physiological compound protecting by yet puzzling mechanism(s) against ischaemia-reperfusion injury: current knowledge. British journal of pharmacology, 2012, Volume: 165, Issue:7 Topics: Animals; Cell Membrane; Cells, Cultured; Glycine; Humans; In Vitro Techniques; Inflammation; Intesti	2012
L-Glycine: a novel antiinflammatory, immunomodulatory, and cytoprotective agent. Current opinion in clinical nutrition and metabolic care, 2003, Volume: 6, Issue:2 Topics: Adjuvants, Immunologic; Anti-Inflammatory Agents; Calcium Channels; Chloride Channels; Cytoprotectio	2003
L-Glycine: a novel antiinflammatory, immunomodulatory, and cytoprotective agent. Current opinion in clinical nutrition and metabolic care, 2003, Volume: 6, Issue:2 Topics: Adjuvants, Immunologic; Anti-Inflammatory Agents; Calcium Channels; Chloride Channels; Cytoprotectio	2003
L-Glycine: a novel antiinflammatory, immunomodulatory, and cytoprotective agent. Current opinion in clinical nutrition and metabolic care, 2003, Volume: 6, Issue:2 Topics: Adjuvants, Immunologic; Anti-Inflammatory Agents; Calcium Channels; Chloride Channels; Cytoprotectio	2003
L-Glycine: a novel antiinflammatory, immunomodulatory, and cytoprotective agent. Current opinion in clinical nutrition and metabolic care, 2003, Volume: 6, Issue:2 Topics: Adjuvants, Immunologic; Anti-Inflammatory Agents; Calcium Channels; Chloride Channels; Cytoprotectio	2003
New aspects on reperfusion injury to liver--impact of organ harvest. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2004, Volume: 19 Suppl 4 Topics: Animals; Glycine; Humans; Kupffer Cells; Lipid Peroxidation; Liver; Liver Transplantation; Living Do	2004
The role of glycine in hepatic ischemia-reperfusion injury. Current pharmaceutical design, 2006, Volume: 12, Issue:23 Topics: Animals; Glycine; Humans; Liver; Liver Diseases; Reperfusion Injury	2006
Kupffer cell-dependent reperfusion injury in liver transplantation: new clinically relevant use of glycine. Langenbecks Archiv fur Chirurgie. Supplement. Kongressband. Deutsche Gesellschaft fur Chirurgie. Kongress, 1998, Volume: 115 Topics: Fatty Liver; Glycine; Humans; Kupffer Cells; Liver; Liver Transplantation; Reperfusion Injury; Risk	1998
Glycine: a new anti-inflammatory immunonutrient. Cellular and molecular life sciences : CMLS, 1999, Nov-30, Volume: 56, Issue:9-10 Topics: Alcohols; Animals; Anti-Inflammatory Agents; Calcium Channels, L-Type; Chloride Channels; Cyclospori	1999

Article	Year
The effect of the neutrophil elastase inhibitor sivelestat on early injury after liver resection. World journal of surgery, 2012, Volume: 36, Issue:5 Topics: Aged; Biomarkers; Drug Administration Schedule; Female; Glycine; Hepatectomy; HMGB1 Protein; Humans;	2012
A study of the metabolites of ischemia-reperfusion injury and selected amino acids in the liver using microdialysis during transplantation. Transplantation, 2005, Apr-15, Volume: 79, Issue:7 Topics: Adult; Aged; Amino Acids; Citrulline; Female; Glutamine; Glycine; Humans; Liver; Liver Function Test	2005

Article	Year
Roxadustat (FG-4592) protects against ischaemia/reperfusion-induced acute kidney injury through inhibiting the mitochondrial damage pathway in mice. Clinical and experimental pharmacology & physiology, 2022, Volume: 49, Issue:2 Topics: Acute Kidney Injury; Animals; Apoptosis; Glycine; Ischemia; Isoquinolines; Kidney; Mice; Mice, Inbre	2022
Reoxygenation induces reactive oxygen species production and ferroptosis in renal tubular epithelial cells by activating aryl hydrocarbon receptor. Molecular medicine reports, 2021, Volume: 23, Issue:1 Topics: alpha-Tocopherol; Animals; Azo Compounds; Basic Helix-Loop-Helix Transcription Factors; Cell Hypoxia	2021
Anti-anemia drug FG4592 retards the AKI-to-CKD transition by improving vascular regeneration and antioxidative capability. Clinical science (London, England : 1979), 2021, 07-30, Volume: 135, Issue:14 Topics: Acute Kidney Injury; Animals; Antioxidants; Disease Models, Animal; Fibrosis; Glycine; Isoquinolines	2021
Glycine-nitronyl nitroxide conjugate protects human umbilical vein endothelial cells against hypoxia/reoxygenation injury via multiple mechanisms and ameliorates hind limb ischemia/reperfusion injury in rats. Biochemical and biophysical research communications, 2017, 06-17, Volume: 488, Issue:1 Topics: Animals; Antioxidants; Apoptosis; Cells, Cultured; Glycine; Hindlimb; Human Umbilical Vein Endotheli	2017
A non-ionotropic activity of NMDA receptors contributes to glycine-induced neuroprotection in cerebral ischemia-reperfusion injury. Scientific reports, 2017, 06-15, Volume: 7, Issue:1 Topics: Animals; Brain Ischemia; Disease Models, Animal; Glutamic Acid; Glycine; Male; Neuroprotection; Prot	2017
Effect of Glycine, Pyruvate, and Resveratrol on the Regeneration Process of Postischemic Intestinal Mucosa. BioMed research international, 2017, Volume: 2017 Topics: Animals; beta-Fructofuranosidase; Cell Proliferation; Disease Models, Animal; Glycine; Injections, I	2017
Cold Storage Injury to Rat Small-bowel Transplants-Beneficial Effect of a Modified HTK Solution. Transplantation, 2018, Volume: 102, Issue:10 Topics: Alanine; Animals; Cell Hypoxia; Cold Ischemia; Disease Models, Animal; Glucose; Glycine; Humans; Int	2018
Glycine Protects the Liver from Reperfusion Injury following Pneumoperitoneum. European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes, 2018, Volume: 59, Issue:1-2 Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Female; Glycine; Kupffer Cells; Liver; P	2018
Improvement of Normothermic Ex Vivo Machine Perfusion of Rat Liver Grafts by Dialysis and Kupffer Cell Inhibition With Glycine. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 2019, Volume: 25, Issue:2 Topics: Allografts; Animals; Disease Models, Animal; Extracorporeal Circulation; Glycine; Hemodiafiltration;	2019
Glycine protects partial liver grafts from Kupffer cell-dependent ischemia-reperfusion injury without negative effect on regeneration. Amino acids, 2019, Volume: 51, Issue:6 Topics: Animals; Female; Glycine; Ki-67 Antigen; Kupffer Cells; Liver; Liver Regeneration; Liver Transplanta	2019
Compared effects of inhibition and exogenous administration of hydrogen sulphide in ischaemia-reperfusion injury. Critical care (London, England), 2013, Jul-10, Volume: 17, Issue:4 Topics: Acidosis, Lactic; Adamantane; Adenosine Triphosphate; Alkynes; Animals; Cytokines; Disease Models, A	2013
Sivelestat sodium hydrate inhibits neutrophil migration to the vessel wall and suppresses hepatic ischemia-reperfusion injury. Digestive diseases and sciences, 2014, Volume: 59, Issue:4 Topics: Animals; Cell Adhesion; Chemotaxis, Leukocyte; Disease Models, Animal; Dose-Response Relationship, D	2014
Glycine aggravates ischemia reperfusion-induced acute kidney injury through N-Methyl-D-Aspartate receptor activation in rats. Molecular and cellular biochemistry, 2014, Volume: 393, Issue:1-2 Topics: Acute Kidney Injury; Animals; Binding Sites; Glycine; Humans; Kidney; Kynurenic Acid; Rats; Receptor	2014
Effect of Gua Lou Gui Zhi decoction on focal cerebral ischemia-reperfusion injury through regulating the expression of excitatory amino acids and their receptors. Molecular medicine reports, 2014, Volume: 10, Issue:1 Topics: Animals; Aspartic Acid; Chromatography, High Pressure Liquid; Disease Models, Animal; Drugs, Chinese	2014
[Effect of a new derivative of glutamic and apovincaminic acids on brain metabolism in post-ischemic period]. Eksperimental'naia i klinicheskaia farmakologiia, 2014, Volume: 77, Issue:2 Topics: Acidosis, Lactic; Animals; Blood Glucose; Brain; Brain Ischemia; Cats; Glutamic Acid; Glycine; Lacti	2014
Glycine selectively reduces intestinal injury during endotoxemia. The Journal of surgical research, 2014, Volume: 192, Issue:2 Topics: Animals; Disease Models, Animal; Endotoxemia; Enteritis; Gastrointestinal Hemorrhage; Glycine; Glyci	2014
Dynamic metabolites profile of cerebral ischemia/reperfusion revealed by (1)H NMR-based metabolomics contributes to potential biomarkers. International journal of clinical and experimental pathology, 2014, Volume: 7, Issue:7 Topics: Animals; Biomarkers; Brain Ischemia; Disease Models, Animal; Glycine; Magnetic Resonance Spectroscop	2014
Hydrogen sulfide accelerates the recovery of kidney tubules after renal ischemia/reperfusion injury. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2015, Volume: 30, Issue:9 Topics: Air Pollutants; Alkynes; Animals; Blotting, Western; Cell Proliferation; Cystathionine beta-Synthase	2015
Prolonged Mouse Cardiac Graft Cold Storage via Attenuating Ischemia-Reperfusion Injury Using a New Antioxidant-Based Preservation Solution. Transplantation, 2016, Volume: 100, Issue:5 Topics: Animals; Antioxidants; Apoptosis; Ascorbic Acid; Cold Temperature; Cryopreservation; Cysteine; Glyci	2016
Effect of non-essential amino acid glycine administration on the liver regeneration of partially hepatectomized rats with hepatic ischemia/reperfusion injury. Clinical nutrition (Edinburgh, Scotland), 2008, Volume: 27, Issue:5 Topics: Animals; Glycine; Hepatectomy; Liver; Liver Regeneration; Male; Organ Size; Rats; Rats, Wistar; Repe	2008
Effect of intracellular lipid droplets on cytosolic Ca2+ and cell death during ischaemia-reperfusion injury in cardiomyocytes. The Journal of physiology, 2009, Mar-15, Volume: 587, Issue:Pt 6 Topics: Animals; Calcium; Cell Death; Cell Hypoxia; Cell Line; Cells, Cultured; Cytoplasmic Granules; Cytoso	2009
Prevention of leukocyte activation by the neutrophil elastase inhibitor, sivelestat, in the hepatic microcirculation after ischemia-reperfusion. The Journal of surgical research, 2009, Volume: 155, Issue:2 Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Glycine; Leukocytes; Lipid Peroxidation;	2009
Protective effect of new nitrosothiols on the early inflammatory response to kidney ischemia/reperfusion and transplantation in rats. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 2009, Volume: 29, Issue:8 Topics: Animals; Cold Ischemia; Cytokines; Glycine; Immunity, Innate; Inflammation Mediators; Kidney Transpl	2009
Renal ischemia/reperfusion injury in rats is attenuated by a synthetic glycine derivative. European journal of pharmacology, 2009, Aug-15, Volume: 616, Issue:1-3 Topics: Acetylcholine; Animals; Anti-Inflammatory Agents; Blood Urea Nitrogen; Free Radical Scavengers; Glut	2009
Fundamental efforts toward the development of a therapeutic cocktail with a manifold ameliorative effect on hepatic ischemia/reperfusion injury. Microcirculation (New York, N.Y. : 1994), 2009, Volume: 16, Issue:7 Topics: Alanine; Animals; Arginine; Chemotaxis, Leukocyte; Clinical Enzyme Tests; Drug Therapy, Combination;	2009
Multifactorial biological modulation of warm ischemia reperfusion injury in liver transplantation from non-heart-beating donors eliminates primary nonfunction and reduces bile salt toxicity. Annals of surgery, 2009, Volume: 250, Issue:5 Topics: alpha-Tocopherol; Animals; Bile Acids and Salts; Female; Fibrinolytic Agents; Glutathione; Glycine;	2009
Multifactorial biological modulation of warm ischemia reperfusion injury in liver transplantation from non-heart-beating donors eliminates primary nonfunction and reduces bile salt toxicity. Annals of surgery, 2009, Volume: 250, Issue:5 Topics: alpha-Tocopherol; Animals; Bile Acids and Salts; Female; Fibrinolytic Agents; Glutathione; Glycine;	2009
Multifactorial biological modulation of warm ischemia reperfusion injury in liver transplantation from non-heart-beating donors eliminates primary nonfunction and reduces bile salt toxicity. Annals of surgery, 2009, Volume: 250, Issue:5 Topics: alpha-Tocopherol; Animals; Bile Acids and Salts; Female; Fibrinolytic Agents; Glutathione; Glycine;	2009
Multifactorial biological modulation of warm ischemia reperfusion injury in liver transplantation from non-heart-beating donors eliminates primary nonfunction and reduces bile salt toxicity. Annals of surgery, 2009, Volume: 250, Issue:5 Topics: alpha-Tocopherol; Animals; Bile Acids and Salts; Female; Fibrinolytic Agents; Glutathione; Glycine;	2009
Glutamate excitotoxicity mediates neuronal apoptosis after hypothermic circulatory arrest. The Annals of thoracic surgery, 2010, Volume: 89, Issue:2 Topics: Animals; Apoptosis; Brain; Circulatory Arrest, Deep Hypothermia Induced; Citrulline; Dizocilpine Mal	2010
The protective function of neutrophil elastase inhibitor in liver ischemia/reperfusion injury. Transplantation, 2010, May-15, Volume: 89, Issue:9 Topics: Animals; Chemokine CXCL1; DNA Primers; Glycine; Humans; Immunohistochemistry; Inflammation; Interleu	2010
Platelet adhesion in the sinusoid caused hepatic injury by neutrophils after hepatic ischemia reperfusion. Platelets, 2010, Volume: 21, Issue:4 Topics: Animals; Blood Platelets; Cytokines; Glycine; Liver; Liver Circulation; Liver Diseases; Male; Neutro	2010
A glycine site-specific NMDA receptor antagonist protects retina ganglion cells from ischemic injury by modulating apoptotic cascades. Journal of cellular physiology, 2010, Volume: 223, Issue:3 Topics: Animals; Apoptosis; Cytoprotection; Eye Proteins; Frozen Sections; Gene Expression Regulation; Glyci	2010
Neutrophil elastase contributes to the development of ischemia/reperfusion-induced liver injury by decreasing the production of insulin-like growth factor-I in rats. Translational research : the journal of laboratory and clinical medicine, 2010, Volume: 155, Issue:6 Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Calcitonin Gene-Related Peptide; Cephalo	2010
Protective effect of sivelestat, a neutrophil elastase inhibitor, on ipsilateral and contralateral testes after unilateral testicular ischaemia-reperfusion injury in rats. BJU international, 2011, Volume: 107, Issue:2 Topics: Animals; Glycine; HSP70 Heat-Shock Proteins; Male; Peroxidase; Proteinase Inhibitory Proteins, Secre	2011
Decreased vasoconstrictor responses in remote cerebral arteries after focal brain ischemia and reperfusion in the rat, in vitro. European journal of pharmacology, 2010, Oct-10, Volume: 644, Issue:1-3 Topics: Animals; Brain Ischemia; Cerebral Arteries; Free Radical Scavengers; Glycine; Infarction, Middle Cer	2010
Glycine maintains mitochondrial activity and bile composition following warm liver ischemia-reperfusion injury. Journal of gastroenterology and hepatology, 2011, Volume: 26, Issue:1 Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Bile; Disease Models, Animal; Electron T	2011
Glycine and taurine equally prevent fatty livers from Kupffer cell-dependent injury: an in vivo microscopy study. Microcirculation (New York, N.Y. : 1994), 2011, Volume: 18, Issue:3 Topics: Animals; Cell Communication; Clinical Enzyme Tests; Fatty Liver; Female; Glycine; Kupffer Cells; Mic	2011
Hypoxia-inducible factor-1α-dependent protection from intestinal ischemia/reperfusion injury involves ecto-5'-nucleotidase (CD73) and the A2B adenosine receptor. Journal of immunology (Baltimore, Md. : 1950), 2011, Apr-01, Volume: 186, Issue:7 Topics: 5'-Nucleotidase; Amino Acids, Dicarboxylic; Animals; Colitis; Glycine; Hypoxia-Inducible Factor 1, a	2011
Protection from glycine at low doses in ischemia-reperfusion injury of the rat small intestine. European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes, 2011, Volume: 46, Issue:4 Topics: Animals; Glycine; Infusions, Intravenous; Intestine, Small; Male; Rats; Rats, Wistar; Reperfusion In	2011
Effect of ginkgolide B on striatal extracellular amino acids in middle cerebral artery occluded rats. Journal of ethnopharmacology, 2011, Jun-14, Volume: 136, Issue:1 Topics: Amino Acids; Animals; Aspartic Acid; Brain Ischemia; Corpus Striatum; gamma-Aminobutyric Acid; Ginkg	2011
[Pharmacological neuroprotection against brain damage in ischemiai/reperfusion experiment]. Eksperimental'naia i klinicheskaia farmakologiia, 2011, Volume: 74, Issue:8 Topics: Animals; Brain; Drug Combinations; Drug Evaluation, Preclinical; Eosine Yellowish-(YS); Flavin Monon	2011
Gastroprotective effect of NaHS against mucosal lesions induced by ischemia-reperfusion injury in rat. Digestive diseases and sciences, 2012, Volume: 57, Issue:6 Topics: Alkynes; Animals; Biopsy, Needle; Cystine; Cytokines; Disease Models, Animal; Enzyme-Linked Immunoso	2012
Glycine preconditioning to ameliorate pulmonary ischemia reperfusion injury in rats. Interactive cardiovascular and thoracic surgery, 2012, Volume: 14, Issue:5 Topics: Animals; Apoptosis; Cytochromes c; Cytoprotection; Disease Models, Animal; Electron Transport Chain	2012
Neutrophil elastase inhibitor improves survival rate after ischemia reperfusion injury caused by supravisceral aortic clamping in rats. The Journal of surgical research, 2013, Volume: 180, Issue:1 Topics: Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Constriction; Glycine; Intestines; Male; Prot	2013
Mitochondrial ROS production and subsequent ERK phosphorylation are necessary for temperature preconditioning of isolated ventricular myocytes. Cell death & disease, 2012, Jul-05, Volume: 3 Topics: Animals; Cells, Cultured; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; Free R	2012
Glycine attenuates cerebral ischemia/reperfusion injury by inhibiting neuronal apoptosis in mice. Neurochemistry international, 2012, Volume: 61, Issue:5 Topics: Animals; Apoptosis; Brain Ischemia; Disease Models, Animal; Glycine; Male; Mice; Mice, Inbred ICR; N	2012
Treatment with a novel hypoxia-inducible factor hydroxylase inhibitor (TRC160334) ameliorates ischemic acute kidney injury. American journal of nephrology, 2012, Volume: 36, Issue:3 Topics: Acute Kidney Injury; Animals; Cell Line, Tumor; Creatinine; Disease Models, Animal; Dose-Response Re	2012
Inhibition of hydrogen sulfide generation contributes to lung injury after experimental orthotopic lung transplantation. The Journal of surgical research, 2013, Jun-01, Volume: 182, Issue:1 Topics: Alkynes; Animals; Cold Ischemia; Cystathionine gamma-Lyase; Enzyme Inhibitors; Glycine; Hydrogen Sul	2013
Sivelestat improves outcome of crush injury by inhibiting high-mobility group box 1 in rats. Shock (Augusta, Ga.), 2013, Volume: 39, Issue:1 Topics: Acute Lung Injury; Animals; Biomarkers; Carbon Dioxide; Combined Modality Therapy; Crush Syndrome; D	2013
Extended experience with glycine for prevention of reperfusion injury after human liver transplantation. Transplantation proceedings, 2002, Volume: 34, Issue:6 Topics: Adenosine; Adult; Alanine Transaminase; Allopurinol; Aspartate Aminotransferases; Brain Death; Gluta	2002
Glycine but not gadolinium chloride or methyl palmitate reduces postischemic white blood cell accumulation and early graft nonfunction after liver transplantation in the rat. Transplantation proceedings, 2002, Volume: 34, Issue:6 Topics: Animals; Biomarkers; Endothelin-1; Gadolinium; Glycine; Graft Survival; Kupffer Cells; Leukocytes; L	2002
Effect of oxygen derived free radicals and glycine on sodium-potassium adenosine triphosphatase in the basolateral membrane of the kidney in ischemia-reperfusion. Saudi medical journal, 2002, Volume: 23, Issue:11 Topics: Animals; Free Radical Scavengers; Glomerular Basement Membrane; Glycine; Kidney; Lipid Peroxidation;	2002
Neutrophil elastase inhibitor reduces hepatic metastases induced by ischaemia-reperfusion in rats. The European journal of surgery = Acta chirurgica, 2002, Volume: 168, Issue:8-9 Topics: Animals; Glycine; Liver Circulation; Liver Neoplasms, Experimental; Male; Rats; Rats, Inbred F344; R	2002
Mitochondrial permeability transition in the switch from necrotic to apoptotic cell death in ischemic rat hepatocytes. Gastroenterology, 2003, Volume: 124, Issue:2 Topics: Animals; Apoptosis; Caspase 3; Caspase Inhibitors; Caspases; Cells, Cultured; Cyclosporine; Energy M	2003
Involvement of reactive oxygen species in cardiac preconditioning in rats. Antioxidants & redox signaling, 2003, Volume: 5, Issue:1 Topics: Animals; Carnosine; Dose-Response Relationship, Drug; Electron Spin Resonance Spectroscopy; Free Rad	2003
Glycine ameliorates lung reperfusion injury after cold preservation in an ex vivo rat lung model. Transplantation, 2003, Mar-15, Volume: 75, Issue:5 Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Apoptosis; Blood Pressure; Cryopreservation; Cytoprotection; D	2003
The effects of a specific neutrophil elastase inhibitor (ONO-5046) in pulmonary ischemia-reperfusion injury. Transplant international : official journal of the European Society for Organ Transplantation, 2003, Volume: 16, Issue:5 Topics: Animals; Cardiac Output; Female; Glycine; Leukocyte Elastase; Lung Diseases; Lung Transplantation; O	2003
[Preparing the donor with glycine improves survival after liver transplantation in the animal model]. Langenbecks Archiv fur Chirurgie. Supplement. Kongressband. Deutsche Gesellschaft fur Chirurgie. Kongress, 1998, Volume: 115, Issue:Suppl I Topics: Animals; Female; Glycine; Graft Survival; Kupffer Cells; Liver Function Tests; Liver Transplantation	1998
Glycine prevents the induction of apoptosis attributed to mesenteric ischemia/reperfusion injury in a rat model. Surgery, 2003, Volume: 134, Issue:3 Topics: Animals; Apoptosis; Cytoprotection; Dose-Response Relationship, Drug; Glycine; Male; Mesentery; Prot	2003
Protective effect of glycine in mesenteric ischemia and reperfusion injury in a rat model. Journal of vascular surgery, 2003, Volume: 38, Issue:5 Topics: Amino Acids; Animals; Cell Survival; Cytoprotection; Gastrointestinal Motility; Glycine; Intestinal	2003
Neutrophil elastase contributes to the development of ischemia-reperfusion-induced liver injury by decreasing endothelial production of prostacyclin in rats. American journal of physiology. Gastrointestinal and liver physiology, 2004, Volume: 287, Issue:6 Topics: 6-Ketoprostaglandin F1 alpha; Animals; Capillary Permeability; Cephalosporins; Chemokines, CXC; Cycl	2004
Differential effects of ischemia/reperfusion on amacrine cell subtype-specific transcript levels in the rat retina. Brain research, 2004, Nov-12, Volume: 1026, Issue:2 Topics: Amacrine Cells; Animals; Cluster Analysis; gamma-Aminobutyric Acid; Gene Expression Regulation; Glia	2004
An immunocytochemical study on specific amacrine cell subpopulations in the rat retina after ischemia. Brain research, 2004, Nov-12, Volume: 1026, Issue:2 Topics: Amacrine Cells; Animals; Cell Count; Eye Diseases; gamma-Aminobutyric Acid; Gene Expression Regulati	2004
Sivelestat, a neutrophil elastase inhibitor, attenuates neutrophil priming after hepatoenteric ischemia in rabbits. Shock (Augusta, Ga.), 2005, Volume: 23, Issue:2 Topics: Acetylglucosaminidase; Animals; Bronchoalveolar Lavage Fluid; Glycine; Ischemia; L-Lactate Dehydroge	2005
[The effect of glycine on CD14 and NF-kappa B in Kupffer cells from rat liver grafts after ischemia-reperfusion injury]. Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology, 2005, Volume: 13, Issue:3 Topics: Animals; Cells, Cultured; Glycine; Kupffer Cells; Lipopolysaccharide Receptors; Liver; Liver Transpl	2005
Benefit of Kupffer cell modulation with glycine versus Kupffer cell depletion after liver transplantation in the rat: effects on postischemic reperfusion injury, apoptotic cell death graft regeneration and survival. Transplant international : official journal of the European Society for Organ Transplantation, 2005, Volume: 18, Issue:9 Topics: Animals; Apoptosis; Bile; Caspase 3; Caspases; Gadolinium; Glycine; Graft Survival; Kupffer Cells; L	2005
HEGPOL: randomized, placebo controlled, multicenter, double-blind clinical trial to investigate hepatoprotective effects of glycine in the postoperative phase of liver transplantation [ISRCTN69350312]. BMC surgery, 2005, Aug-17, Volume: 5 Topics: Alanine Transaminase; Aspartate Aminotransferases; Clinical Protocols; Cyclosporine; Cytoprotection;	2005
Glycine application and right heart function in a porcine heart transplantation model. Transplant international : official journal of the European Society for Organ Transplantation, 2006, Volume: 19, Issue:3 Topics: Animals; Creatine Kinase, MB Form; Diastole; Glycine; Heart; Heart Transplantation; Ischemia; Liver	2006
Glycine intravenous donor preconditioning is superior to glycine supplementation to low-potassium dextran flush preservation and improves graft function in a large animal lung transplantation model after 24 hours of cold ischemia. The Journal of thoracic and cardiovascular surgery, 2006, Volume: 131, Issue:3 Topics: Animals; Cold Ischemia; Dextrans; Glucose; Glycine; Injections, Intravenous; Lung Transplantation; M	2006
[Homeostatic conditions affect the protective effect of edaravone on ischemic injury in neurons]. Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2006, Volume: 35, Issue:2 Topics: Animals; Animals, Newborn; Antipyrine; Cell Hypoxia; Cells, Cultured; Cerebral Cortex; Edaravone; Gl	2006
Influence of fasting on the effects of dimethylamiloride and oxfenicine on ischaemic-reperfused rat hearts. Archives of physiology and biochemistry, 2006, Volume: 112, Issue:1 Topics: Amiloride; Animals; Carnitine O-Palmitoyltransferase; Cell Survival; Enzyme Inhibitors; Fasting; Fat	2006
Benefical effect of neutrophil elastase inhibitor on renal warm ischemia-reperfusion injury in the rat. Transplantation proceedings, 2006, Volume: 38, Issue:7 Topics: Animals; Disease Models, Animal; Enzyme Inhibitors; Functional Laterality; Glycine; Leukocyte Elasta	2006
Different protection mechanisms after pretreatment with glycine or alpha-lipoic acid in a rat model of warm hepatic ischemia. European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes, 2006, Volume: 38, Issue:6 Topics: Animals; Apoptosis; Cytoprotection; Glutathione Transferase; Glycine; In Situ Nick-End Labeling; L-L	2006
Glycine blunts transplantative liver ischemia-reperfusion injury by downregulating interleukin 1 receptor associated kinase-4. Acta pharmacologica Sinica, 2006, Volume: 27, Issue:11 Topics: Animals; Down-Regulation; Glycine; Interleukin-1 Receptor-Associated Kinases; Lipopolysaccharides; L	2006
Proteomics of ischemia and reperfusion injuries in rabbit myocardium with and without intervention by an oxygen-free radical scavenger. Proteomics, 2006, Volume: 6, Issue:23 Topics: Animals; Energy Metabolism; Free Radical Scavengers; Glycine; Heart; Male; Muscle Proteins; Myocardi	2006
[Effects of Ginkgo biloba extract against excitotoxicity induced by NMDA receptors and mechanism thereof]. Zhonghua yi xue za zhi, 2006, Sep-19, Volume: 86, Issue:35 Topics: Animals; Animals, Newborn; Brain Ischemia; Cell Survival; Cells, Cultured; Dizocilpine Maleate; Exci	2006
Sivelestat reduces reperfusion injury of lungs harvested from endotoxin-primed rats by inhibition of neutrophil-mediated inflammation. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2007, Volume: 26, Issue:4 Topics: Animals; Cytokines; Endotoxins; Escherichia coli; Glycine; Injections, Intraperitoneal; Interleukin-	2007
Hemoglobin induces cytotoxic damage of glycine-preserved renal tubules. Transplant international : official journal of the European Society for Organ Transplantation, 2007, Volume: 20, Issue:10 Topics: Animals; Cells, Cultured; Culture Media; Disease Models, Animal; Female; Glycine; Glycine Agents; He	2007
Addition of a neutrophil elastase inhibitor to the organ flushing solution decreases lung reperfusion injury in rat lung transplantation. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2007, Volume: 32, Issue:5 Topics: Animals; Glycine; Leukocyte Elastase; Lung; Lung Transplantation; Male; Models, Animal; Organ Preser	2007
Glycine reduces hepatic warm ischaemia-reperfusion injury by suppressing inflammatory reactions in rats. Liver international : official journal of the International Association for the Study of the Liver, 2007, Volume: 27, Issue:9 Topics: Alanine Transaminase; Animals; Chemokine CXCL1; Glycine; Glycine Agents; L-Lactate Dehydrogenase; Li	2007
Neutrophil elastase inhibitor, sivelestat sodium hydrate prevents ischemia-reperfusion injury in the rat bladder. Molecular and cellular biochemistry, 2008, Volume: 311, Issue:1-2 Topics: Animals; Glycine; Leukocyte Elastase; Male; Malondialdehyde; Nitrates; Nitrites; Proteinase Inhibito	2008
Post-hypoxic cellular disintegration in glycine-preserved renal tubules is attenuated by hydroxyl radical scavengers and iron chelators. Langenbeck's archives of surgery, 2008, Volume: 393, Issue:3 Topics: Animals; Cell Death; Cell Hypoxia; Cytoplasm; Enzymes; Female; Free Radical Scavengers; Gluconeogene	2008
Protective effect of Sivelestat in a porcine hepatectomy model prepared using an intermittent Pringle method. European journal of pharmacology, 2008, Jun-10, Volume: 587, Issue:1-3 Topics: Animals; Aspartate Aminotransferases; Blood Pressure; Cell Line; Enzyme Inhibitors; Glycine; Heart R	2008
Sivelestat and its role in tissue reperfusion injury. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2008, Volume: 33, Issue:6 Topics: Glycine; Humans; Leukocyte Elastase; Lung; Reperfusion Injury; Serine Proteinase Inhibitors; Sulfona	2008
Perioperative glycine treatment attenuates ischemia/reperfusion injury and ameliorates smooth muscle dysfunction in intestinal transplantation. Transplantation, 2008, May-15, Volume: 85, Issue:9 Topics: Animals; Apoptosis; Cyclooxygenase 2; DNA Primers; Gene Expression Regulation; Glycine; Intercellula	2008
Glycine in Carolina rinse solution reduces reperfusion injury, improves graft function, and increases graft survival after rat liver transplantation. Transplantation proceedings, 1995, Volume: 27, Issue:1 Topics: Adenosine; Alanine Transaminase; Allopurinol; Animals; Aspartate Aminotransferases; Glucose; Glutath	1995
Effects of Ca2+ channel blockers, low Ca2+ medium and glycine on cell Ca2+ and injury in anoxic rabbit proximal tubules. Kidney international, 1994, Volume: 46, Issue:1 Topics: Animals; Calcium; Calcium Channel Blockers; Cell Hypoxia; Cell Survival; Culture Media; Fura-2; Glyc	1994
Protective effects of glycine and esterified gamma-glutamylcysteine on ischemia/reoxygenation injury of rat liver. Transplantation, 1994, Sep-27, Volume: 58, Issue:6 Topics: Animals; Dipeptides; Glutathione; Glycine; Ischemia; Liver; Male; Rats; Rats, Wistar; Reperfusion In	1994
Effect of glycine on isolated, perfused rabbit livers following 48-hour preservation in University of Wisconsin solution without glutathione. Transplant international : official journal of the European Society for Organ Transplantation, 1994, Volume: 7, Issue:3 Topics: Adenosine; Allopurinol; Animals; Glutathione; Glycine; Insulin; Liver; Liver Function Tests; Organ P	1994
Diminution of histidine-induced reoxygenation damage by glycine in posthypoxic renal cells. Advances in experimental medicine and biology, 1994, Volume: 345 Topics: Animals; Cell Hypoxia; Free Radicals; Glycine; Histidine; In Vitro Techniques; Kidney Tubules; Lipid	1994
Increased activation of L-type voltage-dependent calcium channels is associated with glycine enhancement of N-methyl-D-aspartate-stimulated dopamine release in global cerebral ischemia/reperfusion. Journal of neurochemistry, 1994, Volume: 63, Issue:1 Topics: Animals; Brain Ischemia; Calcium Channels; Dogs; Dopamine; Female; Glycine; Isradipine; N-Methylaspa	1994
Long-chain acyl-coenzyme A thioesters and renal hypothermic ischemic injury: effects of glycine flush. Cryobiology, 1993, Volume: 30, Issue:1 Topics: Acyl Coenzyme A; Animals; Cold Temperature; Cryopreservation; Cryoprotective Agents; Dogs; Evaluatio	1993
Neutrophil elastase inhibitor (ONO-5046) decreases cytokine-induced neutrophil chemoattractant after reperfusion of pancreaticoduodenal transplantation in rats. Transplantation, 1996, Apr-15, Volume: 61, Issue:7 Topics: Animals; Chemokines, CXC; Chemotactic Factors; Duodenum; Glycine; Growth Substances; Intercellular S	1996
Effects of neutrophil elastase inhibitor on reperfusion injury in the canine liver. Transplantation proceedings, 1996, Volume: 28, Issue:3 Topics: Alanine Transaminase; Animals; Biomarkers; Dogs; Glycine; Hyaluronic Acid; Ischemia; L-Lactate Dehyd	1996
Effects of a specific neutrophil elastase inhibitor (ONO-5046 Na) and neutrophil depletion using a G-1 column on lung reperfusion injury in dogs. Transplantation proceedings, 1996, Volume: 28, Issue:3 Topics: Animals; Chromatography; Dogs; Glycine; Graft Survival; Ischemia; Leukapheresis; Leukocyte Count; Le	1996
Characterization of hypothermic intestinal ischemia-reperfusion injury in dogs. Effects of glycine. Transplantation, 1996, Jul-27, Volume: 62, Issue:2 Topics: Animals; Dogs; Glycine; Hypertonic Solutions; Hypothermia, Induced; Intestinal Mucosa; Intestine, Sm	1996
Comparison of isolated hepatocytes and tissue slices for study of liver hypothermic preservation/reperfusion injury. Cryobiology, 1996, Volume: 33, Issue:4 Topics: Adenosine; Allopurinol; Animals; Calcium; Cell Separation; Cold Temperature; Fasting; Glutathione; G	1996
Glycine minimizes reperfusion injury in a low-flow, reflow liver perfusion model in the rat. The American journal of physiology, 1996, Volume: 270, Issue:2 Pt 1 Topics: Animals; Glycine; Liver; Liver Circulation; Male; Malondialdehyde; Microcirculation; Rats; Rats, Spr	1996
Protective effect of taurine against reperfusion injury in cultured rat astrocytes. Advances in experimental medicine and biology, 1996, Volume: 403 Topics: Animals; Animals, Newborn; Astrocytes; beta-Alanine; Calcium; Cell Survival; Cells, Cultured; Cerebr	1996
Role of granulocyte elastase in ischemia/reperfusion injury of rat liver. Critical care medicine, 1996, Volume: 24, Issue:11 Topics: Animals; Bile; Coloring Agents; Glycine; Indocyanine Green; Leukocyte Elastase; Liver; Male; Rats; R	1996
Protection by Carolina rinse solution, acidotic pH, and glycine against lethal reperfusion injury to sinusoidal endothelial cells of rat livers stored for transplantation. Transplantation, 1996, Dec-15, Volume: 62, Issue:11 Topics: Animals; Cell Death; Cells, Cultured; Endothelium; Glycine; Hydrogen-Ion Concentration; Kupffer Cell	1996
Blood clearance of 99mTc-trimethyl-Br-IDA discriminates between different degrees of severe liver ischaemia--reperfusion injury in the rat. European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes, 1997, Volume: 29, Issue:5 Topics: Alanine Transaminase; Aniline Compounds; Animals; Galactosemias; Glycine; Imino Acids; Ischemia; Liv	1997
Mitochondrial permeability transition in pH-dependent reperfusion injury to rat hepatocytes. The American journal of physiology, 1997, Volume: 273, Issue:6 Topics: Adenosine Triphosphate; Aerobiosis; Anaerobiosis; Animals; Cell Death; Cell Survival; Cells, Culture	1997
Mitochondrial dysfunction and cytoskeletal disruption during chemical hypoxia to cultured rat hepatic sinusoidal endothelial cells: the pH paradox and cytoprotection by glucose, acidotic pH, and glycine. Hepatology (Baltimore, Md.), 1998, Volume: 27, Issue:4 Topics: Adenosine Triphosphate; Animals; Cell Hypoxia; Cells, Cultured; Cyclosporine; Cytoprotection; Cytosk	1998
Coronary thrombosis/thrombolysis in pigs: effects of heparin, ASA, and the thrombin inhibitor inogatran. Journal of pharmacological and toxicological methods, 1998, Volume: 39, Issue:2 Topics: Animals; Antithrombins; Aspirin; Blood Flow Velocity; Coronary Thrombosis; Glycine; Hemodynamics; He	1998
Effects of renal cytoprotective agents on erythrocyte membrane stability. Life sciences, 1998, Volume: 63, Issue:11 Topics: Animals; Calcium Channel Blockers; Chloride Channels; Cryoprotective Agents; Erythrocyte Membrane; F	1998
Cyclosporin A increases hypoxia and free radical production in rat kidneys: prevention by dietary glycine. The American journal of physiology, 1998, Volume: 275, Issue:4 Topics: Animals; Creatinine; Cyclosporine; Food, Fortified; Free Radicals; Glomerular Filtration Rate; Glyci	1998
The effect of neutrophil elastase inhibitor in hepatectomy with ischemia in dogs. The Journal of surgical research, 1999, Volume: 81, Issue:2 Topics: Alanine Transaminase; Animals; Biomarkers; Dogs; Endothelium, Vascular; Glycine; Hemorrhage; Hepatec	1999
Intravenous glycine improves survival in rat liver transplantation. The American journal of physiology, 1999, Volume: 276, Issue:4 Topics: Adenosine; Allopurinol; Animals; Female; Gadolinium; Glutathione; Glycine; Graft Survival; Hepatecto	1999
The effects of a neutrophil elastase inhibitor (ONO-5046.Na) and neutrophil depletion using a granulotrap (G-1) column on lung reperfusion injury in dogs. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 1999, Volume: 18, Issue:7 Topics: Animals; Dogs; Drug Evaluation, Preclinical; Glycine; Hemodynamics; Leukapheresis; Leukocyte Elastas	1999
Effect of specific neutrophil elastase inhibitor on ischemia/reperfusion injury in rat liver transplantation. The Journal of surgical research, 1999, Volume: 86, Issue:1 Topics: Adenine Nucleotides; Animals; Bile; Glycine; Hyaluronic Acid; Ischemia; Leukocyte Elastase; Liver; L	1999
Neutrophil elastase inhibitor (ONO-5046) attenuates reperfusion-induced hepatic microcirculatory derangement, energy depletion and lipid peroxidation in rats. Shock (Augusta, Ga.), 1999, Volume: 12, Issue:6 Topics: Adenosine Triphosphate; Animals; Energy Metabolism; Glycine; Hemodynamics; Ischemia; Laser-Doppler F	1999
Protective effects of ONO-5046Na, a specific neutrophil elastase inhibitor, on postperfusion lung injury. The Annals of thoracic surgery, 1999, Volume: 68, Issue:6* Topics: Animals; Cardiopulmonary Bypass; Dogs; Extravascular Lung Water; Glycine; Hemodynamics; Interleukin-	1999
The role of hepatobiliary scintigraphy in the evaluation of the protective effects of dimethylsulphoxide in ischaemic/reperfusion injury of liver. Nuclear medicine communications, 2000, Volume: 21, Issue:8 Topics: Aniline Compounds; Animals; Biliary Tract; Cell Death; Dimethyl Sulfoxide; Glycine; Imino Acids; Liv	2000
Glucagonlike peptide-2 analogue enhances intestinal mucosal mass and absorptive function after ischemia-reperfusion injury. Journal of pediatric surgery, 2000, Volume: 35, Issue:11 Topics: Animals; Disease Models, Animal; DNA; Galactose; Glucagon-Like Peptides; Glycine; Infusions, Intrave	2000
Effect of perhexiline and oxfenicine on myocardial function and metabolism during low-flow ischemia/reperfusion in the isolated rat heart. Journal of cardiovascular pharmacology, 2000, Volume: 36, Issue:6 Topics: Animals; Calcium Channel Blockers; Carnitine O-Palmitoyltransferase; Coronary Circulation; Enzyme In	2000
Glycine preserves function and decreases necrosis in skeletal muscle undergoing ischemia and reperfusion injury. Surgery, 2001, Volume: 129, Issue:2 Topics: Adenosine Triphosphate; Animals; Disease Models, Animal; Dogs; Glycine; Infusions, Intra-Arterial; I	2001
Pretreatment with glycine reduces the severity of warm intestinal ischemic-reperfusion injury in the rat. Annals of plastic surgery, 2001, Volume: 46, Issue:3 Topics: Animals; Chi-Square Distribution; Glycine; Infusions, Intra-Arterial; Ischemia; Jejunum; Male; Rats;	2001
Effect of a neutrophil elastase inhibitor (ONO-5046 Na) on ischemia/reperfusion injury using the left-sided heterotopic canine heart transplantation model. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2001, Volume: 20, Issue:8 Topics: Animals; Cytokines; Dogs; Glycine; Heart Transplantation; Inflammation Mediators; Leukocyte Elastase	2001
Effects of neutrophil elastase inhibitor (ONO-5046) on lung injury after intestinal ischemia-reperfusion. Journal of applied physiology (Bethesda, Md. : 1985), 2001, Volume: 91, Issue:4 Topics: Animals; Bronchoalveolar Lavage Fluid; Chemokine CXCL1; Chemokines; Chemokines, CXC; Chemotactic Fac	2001
[Effect of guizhi fuling pills on the changes of Ca2+ and amino acids in rats with cerebral ischemia and reperfusion]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 1998, Volume: 23, Issue:9 Topics: Animals; Brain; Brain Ischemia; Calcium; Drug Combinations; Drugs, Chinese Herbal; Female; gamma-Ami	1998
Selective mGluR5 receptor antagonist or agonist provides neuroprotection in a rat model of focal cerebral ischemia. Brain research, 2001, Dec-20, Volume: 922, Issue:2 Topics: Animals; Body Temperature; Body Weight; Brain Ischemia; Cell Survival; Cerebral Cortex; Disease Mode	2001
Protective effect of glycine on renal injury induced by ischemia-reperfusion in vivo. American journal of physiology. Renal physiology, 2002, Volume: 282, Issue:3 Topics: Animals; Electron Spin Resonance Spectroscopy; Female; Free Radicals; Glycine; Hypoxia; Kidney Disea	2002
Interleukin-11 enhances intestinal absorptive function after ischemia-reperfusion injury. Journal of pediatric surgery, 2002, Volume: 37, Issue:3 Topics: Animals; Carbon Radioisotopes; Disease Models, Animal; DNA; Galactose; Glycine; Interleukin-11; Inte	2002
Reduced reperfusion injury by glycine in a porcine liver transplantation model with non-heart-beating donors. Transplantation proceedings, 2002, Volume: 34, Issue:4 Topics: Animals; Glycine; Graft Survival; Heart Arrest; Humans; Liver Circulation; Liver Function Tests; Liv	2002
Effect of glycine and hypertrophy on renal outer medullary hypoxic injury in ischemia reflow and contrast nephropathy. American journal of kidney diseases : the official journal of the National Kidney Foundation, 1992, Volume: 19, Issue:6 Topics: Animals; Cell Hypoxia; Glycine; Hypertrophy; Iothalamic Acid; Kidney Medulla; Kidney Tubular Necrosi	1992
Amino acids to suppress reperfusion injury after liver preservation. Transplantation proceedings, 1991, Volume: 23, Issue:5 Topics: Adenosine; Allopurinol; Amino Acids; Animals; Dogs; Glutathione; Glycine; Insulin; Liver; Liver Func	1991
Protective effects of glycine during hypothermic renal ischemia-reperfusion injury. The American journal of physiology, 1991, Volume: 261, Issue:5 Pt 2 Topics: Acetyl Coenzyme A; Acyl Coenzyme A; Adenine Nucleotides; Animals; Dogs; Glutathione; Glycine; Hypoth	1991

glycine and Reperfusion Injury

Research Excerpts

Research

Studies (139)

Authors

Clinical Trials (6)

Trial Overview

Trial Outcomes

Changes in Serum Concentration of Inflammatory Biomarkers (TNF-alpha)

Changes in Sputum Concentration of Inflammatory Biomarkers (G-CSF)

Changes in Sputum Concentration of Inflammatory Biomarkers (IL-6)

Changes in Clinical Data Scores (Other Than Sputum Production, Dyspnea and Global Symptoms)

Changes in FEV1, FEF25, and FEFmax

Changes in Other Spirometric Variables

Changes in Pulse Oximetry, FEV1/FVC, and FEF50.

Changes in Score for Sputum Production, Dyspnea and Global Symptoms

Changes in Serum Concentration of Inflammatory Biomarkers (Other Than TNF-alpha)

Changes in Sputum Concentration of Inflammatory Biomarkers (Other Than IL-6 and G-CSF)

Reviews

Trials

Other Studies