glycine has been researched along with Precursor Cell Lymphoblastic Leukemia-Lymphoma in 8 studies
Precursor Cell Lymphoblastic Leukemia-Lymphoma: A neoplasm characterized by abnormalities of the lymphoid cell precursors leading to excessive lymphoblasts in the marrow and other organs. It is the most common cancer in children and accounts for the vast majority of all childhood leukemias.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pemetrexed represents the first antifolate cancer drug to be approved by the Food and Drug Administration in 20 years; it is currently in widespread use for first line therapy of mesothelioma and non-small cell lung cancer." | 3.75 | Therapeutics by cytotoxic metabolite accumulation: pemetrexed causes ZMP accumulation, AMPK activation, and mammalian target of rapamycin inhibition. ( Heyer, CL; Moran, RG; Racanelli, AC; Rothbart, SB, 2009) |
| "Acute lymphoblastic leukemia (ALL) is a disease of lymphoid progenitor cells with an often aggressive course and is commonly caused by the BCR-ABL fusion gene t(9;22) in adults." | 1.72 | Combined inhibition of BCR-ABL1 and the proteasome as a potential novel therapeutic approach in BCR-ABL positive acute lymphoblastic leukemia. ( Appelmann, I; Brümmendorf, TH; Koschmieder, S; Maletzke, S; Masouleh, BK; Salimi, A; Schemionek, M; Schroeder, KM; Vieri, M, 2022) |
| "Ixazomib (IXA) is an orally available proteasome inhibitor, with an improved safety profile compared to Bortezomib (BTZ)." | 1.62 | Pre-Clinical Evaluation of the Proteasome Inhibitor Ixazomib against Bortezomib-Resistant Leukemia Cells and Primary Acute Leukemia Cells. ( Cloos, J; Jansen, G; Kaspers, GJL; Kwidama, ZJ; Roeten, MSF; Segerink, WH; Ter Huizen, G; van Meerloo, J; Zweegman, S, 2021) |
| "We propose that patients whose tumors show this phenotype will be sensitive to folate antagonists targeting thymidylate or purine biosynthesis." | 1.39 | Overexpression of the mitochondrial folate and glycine-serine pathway: a new determinant of methotrexate selectivity in tumors. ( Bertino, JR; Tedeschi, PM; Vazquez, A, 2013) |
| "We studied 170 patients with acute lymphoblastic leukemia (ALL), treated from 1988 to 1994 according to a protocol derived from BFM-83 studies, in order to evaluate the incidence and prognostic significance of mutations in this gene in childhood ALL." | 1.31 | Lack of association between N-ras gene mutations and clinical prognosis in Brazilian children with acute lymphoblastic leukemia. ( Clementino, NC; Costa, FF; Figueiredo, MS; Kerbauy, J; Saad, ST; Viana, MB; Yamamoto, M, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 3 (37.50) | 24.3611 |
| 2020's | 3 (37.50) | 2.80 |
| Authors | Studies |
|---|---|
| Amrein, P | 1 |
| Ballen, K | 1 |
| Stevenson, K | 1 |
| Brunner, A | 1 |
| Hobbs, G | 1 |
| Hock, H | 1 |
| McAfee, S | 1 |
| Moran, J | 1 |
| Bergeron, M | 1 |
| Foster, J | 1 |
| Bertoli, C | 1 |
| McGreggor, K | 1 |
| Macrea, M | 1 |
| Burke, M | 1 |
| Behnam, T | 1 |
| Som, T | 1 |
| Ramos, A | 1 |
| Vartanian, M | 1 |
| Lombardi Story, J | 1 |
| Connolly, C | 1 |
| Blonquist, T | 1 |
| Neuberg, D | 1 |
| Fathi, A | 1 |
| Maletzke, S | 1 |
| Salimi, A | 1 |
| Vieri, M | 1 |
| Schroeder, KM | 1 |
| Schemionek, M | 1 |
| Masouleh, BK | 1 |
| Brümmendorf, TH | 1 |
| Koschmieder, S | 1 |
| Appelmann, I | 1 |
| Roeten, MSF | 1 |
| van Meerloo, J | 1 |
| Kwidama, ZJ | 1 |
| Ter Huizen, G | 1 |
| Segerink, WH | 1 |
| Zweegman, S | 1 |
| Kaspers, GJL | 1 |
| Jansen, G | 1 |
| Cloos, J | 1 |
| Racanelli, AC | 1 |
| Rothbart, SB | 1 |
| Heyer, CL | 1 |
| Moran, RG | 1 |
| Ganguly, A | 1 |
| Basu, S | 1 |
| Banerjee, K | 1 |
| Chakraborty, P | 1 |
| Sarkar, A | 1 |
| Chatterjee, M | 1 |
| Chaudhuri, SK | 1 |
| Oussenko, IA | 1 |
| Holland, JF | 1 |
| Reddy, EP | 1 |
| Ohnuma, T | 1 |
| Vazquez, A | 1 |
| Tedeschi, PM | 1 |
| Bertino, JR | 1 |
| Clementino, NC | 1 |
| Yamamoto, M | 1 |
| Viana, MB | 1 |
| Figueiredo, MS | 1 |
| Kerbauy, J | 1 |
| Saad, ST | 1 |
| Costa, FF | 1 |
8 other studies available for glycine and Precursor Cell Lymphoblastic Leukemia-Lymphoma
| Article | Year |
|---|---|
Ixazomib in addition to chemotherapy for the treatment of acute lymphoblastic leukemia in older adults.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Boron Compounds; Glycine; Humans; Precursor Ce | 2022 |
Combined inhibition of BCR-ABL1 and the proteasome as a potential novel therapeutic approach in BCR-ABL positive acute lymphoblastic leukemia.
Topics: Adult; Aged; Boron Compounds; Bortezomib; Dasatinib; Drug Resistance, Neoplasm; Fusion Proteins, bcr | 2022 |
Pre-Clinical Evaluation of the Proteasome Inhibitor Ixazomib against Bortezomib-Resistant Leukemia Cells and Primary Acute Leukemia Cells.
Topics: Boron Compounds; Bortezomib; Cell Line, Tumor; Drug Resistance, Neoplasm; Glycine; Humans; Leukemia, | 2021 |
Therapeutics by cytotoxic metabolite accumulation: pemetrexed causes ZMP accumulation, AMPK activation, and mammalian target of rapamycin inhibition.
Topics: Adenylate Kinase; Aminoimidazole Carboxamide; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; | 2009 |
Redox active copper chelate overcomes multidrug resistance in T-lymphoblastic leukemia cell by triggering apoptosis.
Topics: Animals; Antibiotics, Antineoplastic; Apoptosis; Blotting, Western; Cell Cycle; Cell Line; Cell Line | 2011 |
Effect of ON 01910.Na, an anticancer mitotic inhibitor, on cell-cycle progression correlates with RanGAP1 hyperphosphorylation.
Topics: Camptothecin; Cell Cycle; Cell Line, Tumor; DNA Damage; Doxorubicin; Glycine; GTPase-Activating Prot | 2011 |
Overexpression of the mitochondrial folate and glycine-serine pathway: a new determinant of methotrexate selectivity in tumors.
Topics: Biological Transport; Folic Acid; Folic Acid Antagonists; Glycine; Humans; Methotrexate; Mitochondri | 2013 |
Lack of association between N-ras gene mutations and clinical prognosis in Brazilian children with acute lymphoblastic leukemia.
Topics: Amino Acid Substitution; Base Sequence; Bone Marrow Cells; Brazil; Child; Child, Preschool; Cloning, | 2001 |