Page last updated: 2024-10-18

glycine and Obesity

glycine has been researched along with Obesity in 98 studies

Obesity: A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).

Research Excerpts

ExcerptRelevanceReference
"The metabolic signature associated with obesity is characterized by a decrease in plasma glycine concentration, a feature closely associated with insulin resistance and highly predictive of the risk of developing chronic metabolic diseases."9.41Alterations in glycine metabolism in obesity and chronic metabolic diseases - an update on new advances. ( Alves, A; Morio, B, 2023)
"Glycine supplementation improves various components of metabolic syndrome including diabetes, obesity, hyperlipidemia and hypertension."9.22Effects of glycine on metabolic syndrome components: a review. ( Hossenzadeh, H; Imenshahidi, M, 2022)
"To investigate the effect of obesity on the pharmacokinetics and pharmacodynamics of melagatran after oral administration of ximelagatran."9.10No influence of obesity on the pharmacokinetics and pharmacodynamics of melagatran, the active form of the oral direct thrombin inhibitor ximelagatran. ( Eriksson, UG; Homolka, R; Peters, GR; Sarich, TC; Svensson, M; Teng, R; Wollbratt, M, 2003)
" In addition, the plasma level of glycine is decreased in obesity, and the decrease is strongly correlated with the severity of insulin resistance."8.12Glycine Supplementation in Obesity Worsens Glucose Intolerance through Enhanced Liver Gluconeogenesis. ( Alves, A; Bassot, A; Bloise, AMNLG; Chanon, S; Drevet Mulard, E; Godet, M; Lamarche, F; Lefebvre, R; Loizon, E; Morio, B; Panthu, B; Pinteur, C; Rautureau, GJP, 2022)
"Obesity is associated with altered glycine metabolism in humans."7.96Obesity increases hepatic glycine dehydrogenase and aminomethyltransferase expression while dietary glycine supplementation reduces white adipose tissue in Zucker diabetic fatty rats. ( Edwards, AK; McKnight, SM; Satterfield, MC; Simmons, RM; Wu, G, 2020)
"Glycine (Gly) lowers hypercholesterolemia, hypertriglyceridemia and hypertension but its role in preventing adipocyte hypertrophy and modulating enzymatic activity of adipocytes has not been studied."7.83Effect of Glycine on Adipocyte Hypertrophy in a Metabolic Syndrome Rat Model. ( Castro, ES; Díaz-Díaz, E; Espejel, RV; Lans, VG; López, YR; Pérez-Torres, I; Zúñiga-Muñoz, A, 2016)
" The subjects carrying Gly16 or Glu27 alleles regardless of BMI had greater total fat mass, W/H and plasma leptin compared with those without the Gly16 or Glu27 alleles, indicating that Gly16 and Glu27 alleles of the beta2-adrenoceptor gene are related to obesity and fat mass."7.73Beta2-adrenoceptor polymorphisms relate to obesity through blunted leptin-mediated sympathetic activation. ( Fu, Y; Katsuya, T; Kawaguchi, H; Masuo, K; Ogihara, T; Rakugi, H; Tuck, ML, 2006)
"Glycine (Gly) has been reported to enhance the expression of tight-junction proteins in porcine enterocytes."5.62Dietary Supplementation with Glycine Enhances Intestinal Mucosal Integrity and Ameliorates Inflammation in C57BL/6J Mice with High-Fat Diet-Induced Obesity. ( Chen, J; Dai, Z; Kim, IH; Wu, G; Wu, Z; Yang, Y, 2021)
"Obesity was found to be associated with decreased vessel H2S concentration, inward hypertrophic remodeling, altered collagen-to-elastin ratio, and reduced vessel stiffness."5.43Hydrogen sulfide depletion contributes to microvascular remodeling in obesity. ( Candela, J; Velmurugan, GV; White, C, 2016)
"The metabolic signature associated with obesity is characterized by a decrease in plasma glycine concentration, a feature closely associated with insulin resistance and highly predictive of the risk of developing chronic metabolic diseases."5.41Alterations in glycine metabolism in obesity and chronic metabolic diseases - an update on new advances. ( Alves, A; Morio, B, 2023)
"Obesity is associated with insulin resistance and other major cardiovascular risk factors."5.30Plasma leptin levels: interaction of obesity with a common variant of insulin receptor substrate-1. ( Breban, D; Hell, E; Krempler, F; Patsch, W; Winkler, C, 1998)
"Glycine supplementation improves various components of metabolic syndrome including diabetes, obesity, hyperlipidemia and hypertension."5.22Effects of glycine on metabolic syndrome components: a review. ( Hossenzadeh, H; Imenshahidi, M, 2022)
" Furthermore, glycine could be linked to metabolic health and insulin sensitivity through the betaine osmolyte."5.22Network Analysis of Metabolite GWAS Hits: Implication of CPS1 and the Urea Cycle in Weight Maintenance. ( Astrup, A; Carayol, J; Charon, C; Fazelzadeh, P; Hager, J; Lefebvre, G; Matone, A; Morine, M; Saris, WH; Scott-Boyer, MP; Valsesia, A; Vervoort, J, 2016)
"To investigate the effect of obesity on the pharmacokinetics and pharmacodynamics of melagatran after oral administration of ximelagatran."5.10No influence of obesity on the pharmacokinetics and pharmacodynamics of melagatran, the active form of the oral direct thrombin inhibitor ximelagatran. ( Eriksson, UG; Homolka, R; Peters, GR; Sarich, TC; Svensson, M; Teng, R; Wollbratt, M, 2003)
"Humans are exposed to obesity causing Bisphenol A in various ways, especially through diet and food containers."4.31Exposure to environmental pollutant bisphenol A causes oxidative damage and lipid accumulation in Zebrafish larvae: Protective role of WL15 peptide derived from cysteine and glycine-rich protein 2. ( Arockiaraj, J; Guru, A, 2023)
" Glycine-β-muricholic acid (Gly-MCA) is an intestine-specific FXR antagonist previously shown to have favorable metabolic effects on obesity and insulin resistance."4.12Glycine-β-muricholic acid antagonizes the intestinal farnesoid X receptor-ceramide axis and ameliorates NASH in mice. ( Amin, SG; Desai, D; Gao, X; Gonzalez, FJ; Jiang, J; Krausz, KW; Liu, Y; Lu, D; Ma, Y; Patterson, AD; Xie, C, 2022)
" In addition, the plasma level of glycine is decreased in obesity, and the decrease is strongly correlated with the severity of insulin resistance."4.12Glycine Supplementation in Obesity Worsens Glucose Intolerance through Enhanced Liver Gluconeogenesis. ( Alves, A; Bassot, A; Bloise, AMNLG; Chanon, S; Drevet Mulard, E; Godet, M; Lamarche, F; Lefebvre, R; Loizon, E; Morio, B; Panthu, B; Pinteur, C; Rautureau, GJP, 2022)
"Obesity is associated with altered glycine metabolism in humans."3.96Obesity increases hepatic glycine dehydrogenase and aminomethyltransferase expression while dietary glycine supplementation reduces white adipose tissue in Zucker diabetic fatty rats. ( Edwards, AK; McKnight, SM; Satterfield, MC; Simmons, RM; Wu, G, 2020)
"Glycine (Gly) lowers hypercholesterolemia, hypertriglyceridemia and hypertension but its role in preventing adipocyte hypertrophy and modulating enzymatic activity of adipocytes has not been studied."3.83Effect of Glycine on Adipocyte Hypertrophy in a Metabolic Syndrome Rat Model. ( Castro, ES; Díaz-Díaz, E; Espejel, RV; Lans, VG; López, YR; Pérez-Torres, I; Zúñiga-Muñoz, A, 2016)
" Since we demonstrated that glycine supplementation can reduce inflammation and muscle wasting, we hypothesized that glycine supplementation during CR would preserve muscle mass in mice."3.83Glycine supplementation during calorie restriction accelerates fat loss and protects against further muscle loss in obese mice. ( Caldow, MK; Chee, A; Godeassi, DP; Ham, DJ; Koopman, R; Lynch, GS, 2016)
" Here we show that treatment of mice with glycine-β-muricholic acid (Gly-MCA) inhibits FXR signalling exclusively in intestine, and improves metabolic parameters in mouse models of obesity."3.81Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction. ( Amin, SG; Bisson, WH; Brocker, CN; Desai, D; Gavrilova, O; Gonzalez, FJ; Jiang, C; Krausz, KW; Li, J; Liu, Y; Lv, Y; Patterson, AD; Shi, J; Xie, C, 2015)
" In the present study the influence of a four-week daily oral administration of 2 mg/kg body weight ciprofibrate (CAS 52214-84-3) or of 100 mg/kg body weight clofibric acid (CAS 882-09-7) was compared to that of the respective doses of their newly synthesized glycine conjugates in adult male lean and obese Zucker rats."3.74Ciprofibrate, clofibric acid and respective glycinate derivatives. Effects of a four-week treatment on male lean and obese Zucker rats. ( Deufel, T; Fleck, C; Karge, E; Lupp, A; Oelschlägers, H, 2008)
" The subjects carrying Gly16 or Glu27 alleles regardless of BMI had greater total fat mass, W/H and plasma leptin compared with those without the Gly16 or Glu27 alleles, indicating that Gly16 and Glu27 alleles of the beta2-adrenoceptor gene are related to obesity and fat mass."3.73Beta2-adrenoceptor polymorphisms relate to obesity through blunted leptin-mediated sympathetic activation. ( Fu, Y; Katsuya, T; Kawaguchi, H; Masuo, K; Ogihara, T; Rakugi, H; Tuck, ML, 2006)
"To determine whether there are variations in leptin levels according to the beta(3)-adrenoceptor (beta(3)-AR) Trp64Arg and uncoupling protein 1 (UCP1) -3826A-->G polymorphisms, given the regulatory role of catecholamines through the beta(3)-AR in leptin production and the previously reported association of the UCP1 -3826A-->G variant with obesity."3.72The Arg64 allele of the beta 3-adrenoceptor gene but not the -3826G allele of the uncoupling protein 1 gene is associated with increased leptin levels in the Spanish population. ( Fernández-Pérez, C; González-Sánchez, JL; Martínez-Larrad, MT; Palou, A; Proenza, AM; Ramis, JM; Serrano-Ríos, M, 2004)
"The effects of low energy diets on protein metabolism in terms of the metabolic pool, active protein pool, and active and inactive protein synthesis rates were studied using [15N]glycine in five obese patients (percentage of ideal body weight, 120-190%)."3.67Effects of low energy diets on protein metabolism studies with [15N]glycine in obese patients. ( Koh, H; Koishi, H; Kurata, M; Nambu, S; Oi, Y; Okuda, T; Waki, M, 1987)
"Using the glycine-l-14C-cholic acid (14C-GCA) test, bile salt deconjugation and excretion were studied in 26 subjects with morbid exogenous obesity before and at selected intervals after jejuno-ileal bypass."3.65Studies on bile salt deconjugation following small bowel bypass procedures. ( Margraf, H; Stein, T; Wise, L, 1975)
"Given the potential of boron in the treatment of obesity, the aim of this study is to investigate the anti-adipogenic activity of the newly synthesised boron glycine monoester compound (BGM) using 3T3-L1 adipocytes by analysing lipid accumulation, CTRP3 and PPARy gene expression, oxidative stress and apoptotic effects."1.72BGM, a Newly Synthesised Boron Compound, Induces Apoptosis and Reduces Oxidative Stress by Inhibiting Lipogenesis in 3T3-L1 Adipocytes via PPARγ and CTRP3. ( Koldemir Gündüz, M, 2022)
"Glycine (Gly) has been reported to enhance the expression of tight-junction proteins in porcine enterocytes."1.62Dietary Supplementation with Glycine Enhances Intestinal Mucosal Integrity and Ameliorates Inflammation in C57BL/6J Mice with High-Fat Diet-Induced Obesity. ( Chen, J; Dai, Z; Kim, IH; Wu, G; Wu, Z; Yang, Y, 2021)
"Obesity was found to be associated with decreased vessel H2S concentration, inward hypertrophic remodeling, altered collagen-to-elastin ratio, and reduced vessel stiffness."1.43Hydrogen sulfide depletion contributes to microvascular remodeling in obesity. ( Candela, J; Velmurugan, GV; White, C, 2016)
" Moreover, chronic administration of JTT-551 showed an antiobesity effect and an improvement of glucose and lipid metabolism in DIO mice."1.40Pharmacological effects of JTT-551, a novel protein tyrosine phosphatase 1B inhibitor, in diet-induced obesity mice. ( Fukuda, S; Ito, M; Morinaga, H; Ohta, T; Sakata, S, 2014)
"Obesity is widely recognized as cause of metabolic syndrome and cardiovascular disease."1.36Glycine regulates inflammatory markers modifying the energetic balance through PPAR and UCP-2. ( Alarcon-Aguilar, FJ; Almanza-Perez, JC; Blancas-Flores, G; Campos-Sepulveda, AE; Cruz, M; Garcia-Macedo, R; Roman-Ramos, R, 2010)
"Hydrogen sulfide (H(2)S) has been traditionally known for its toxic effects on living organisms."1.35Pancreatic islet overproduction of H2S and suppressed insulin release in Zucker diabetic rats. ( Cao, K; Duridanova, D; Jia, X; Wang, R; Wu, L; Yang, G; Yang, W, 2009)
"Obesity is commonly associated with a high incidence and prevalence of dyslipidaemia, cardiovascular disease and Type II diabetes."1.31The effect of rate of weight loss on erythrocyte glutathione concentration and synthesis in healthy obese men. ( Calder, AG; Duthie, GG; Elia, M; Faber, P; Gibney, ER; Johnstone, AM; Lobley, GE; Stubbs, RJ, 2002)
"Obesity is associated with insulin resistance and other major cardiovascular risk factors."1.30Plasma leptin levels: interaction of obesity with a common variant of insulin receptor substrate-1. ( Breban, D; Hell, E; Krempler, F; Patsch, W; Winkler, C, 1998)

Research

Studies (98)

TimeframeStudies, this research(%)All Research%
pre-199026 (26.53)18.7374
1990's5 (5.10)18.2507
2000's26 (26.53)29.6817
2010's28 (28.57)24.3611
2020's13 (13.27)2.80

Authors

AuthorsStudies
Imenshahidi, M1
Hossenzadeh, H1
Ye, Z1
Zhang, C1
Wang, S1
Zhang, Y1
Li, R1
Zhao, Y1
Qiao, J1
Koldemir Gündüz, M1
Guru, A1
Arockiaraj, J1
Jiang, J1
Ma, Y1
Liu, Y2
Lu, D1
Gao, X1
Krausz, KW2
Desai, D2
Amin, SG2
Patterson, AD2
Gonzalez, FJ2
Xie, C2
Alves, A3
Morio, B3
Lamarche, F1
Lefebvre, R1
Drevet Mulard, E1
Bassot, A2
Chanon, S1
Loizon, E1
Pinteur, C1
Bloise, AMNLG1
Godet, M1
Rautureau, GJP1
Panthu, B1
Hay, RE1
Edwards, A1
Klein, M1
Hyland, L1
MacDonald, D1
Karatsoreos, I1
Hill, MN1
Abizaid, A1
Simmons, RM1
McKnight, SM1
Edwards, AK1
Wu, G2
Satterfield, MC1
White, PJ1
Lapworth, AL1
McGarrah, RW1
Kwee, LC1
Crown, SB1
Ilkayeva, O1
An, J1
Carson, MW1
Christopher, BA1
Ball, JR1
Davies, MN1
Kjalarsdottir, L1
George, T1
Muehlbauer, MJ1
Bain, JR1
Stevens, RD1
Koves, TR1
Muoio, DM1
Brozinick, JT1
Gimeno, RE1
Brosnan, MJ1
Rolph, TP1
Kraus, WE1
Shah, SH1
Newgard, CB1
Camacho-Barcia, L1
García-Gavilán, J1
Papandreou, C1
Hansen, TT1
Harrold, JA1
Finlayson, G1
Blundell, JE1
Sjödin, A1
Halford, JCG1
Bulló, M1
Boutin, JA1
Jullian, M1
Frankiewicz, L1
Galibert, M1
Gloanec, P1
Le Diguarher, T1
Dupuis, P1
Ko, A1
Ripoll, L1
Bertrand, M1
Pecquery, A1
Ferry, G1
Puget, K1
Chen, J1
Yang, Y2
Dai, Z1
Kim, IH1
Wu, Z1
Orellana, ER1
Jamis, C1
Horvath, N1
Hajnal, A1
Vandenbeek, R1
Khan, NP1
Estall, JL1
Margolis, LM1
Ceglia, L1
Rivas, DA1
Dawson-Hughes, B1
Fielding, RA1
Khukhlina, O1
Antoniv, A1
Kanovska, L1
Mandryk, O1
Smandych, V1
Zheng, JQ1
Zhang, GR1
Li, J2
Bi, HW1
Bulteau, AL1
Pirola, L1
Haviland, JA1
Reiland, H1
Butz, DE1
Tonelli, M1
Porter, WP1
Zucchi, R1
Scanlan, TS1
Chiellini, G1
Assadi-Porter, FM1
Geng, B1
Cai, B1
Liao, F1
Zheng, Y1
Zeng, Q1
Fan, X1
Gong, Y1
Yang, J1
Cui, QH1
Tang, C1
Xu, GH1
Linder, DE1
Freeman, LM1
Holden, SL1
Biourge, V1
German, AJ1
Sato, S1
Sakurai, T1
Ogasawara, J1
Takahashi, M1
Izawa, T1
Imaizumi, K1
Taniguchi, N1
Ohno, H1
Kizaki, T1
Jamroz-Wiśniewska, A1
Gertler, A1
Solomon, G1
Wood, ME1
Whiteman, M1
Bełtowski, J1
Tastesen, HS1
Keenan, AH1
Madsen, L1
Kristiansen, K1
Liaset, B1
Ito, M1
Fukuda, S1
Sakata, S1
Morinaga, H1
Ohta, T1
McMurray, F1
Demetriades, M1
Aik, W1
Merkestein, M1
Kramer, H1
Andrew, DS1
Scudamore, CL1
Hough, TA1
Wells, S1
Ashcroft, FM1
McDonough, MA1
Schofield, CJ1
Cox, RD1
Caldow, MK1
Ham, DJ1
Godeassi, DP1
Chee, A1
Lynch, GS1
Koopman, R1
Jiang, C1
Lv, Y1
Shi, J1
Brocker, CN1
Bisson, WH1
Gavrilova, O1
Schmid, A1
Neumann, H1
Karrasch, T1
Liebisch, G1
Schäffler, A1
Matone, A1
Scott-Boyer, MP1
Carayol, J1
Fazelzadeh, P1
Lefebvre, G1
Valsesia, A1
Charon, C1
Vervoort, J1
Astrup, A1
Saris, WH1
Morine, M1
Hager, J1
Candela, J1
Velmurugan, GV1
White, C1
López, YR1
Pérez-Torres, I1
Zúñiga-Muñoz, A1
Lans, VG1
Díaz-Díaz, E1
Castro, ES1
Espejel, RV1
Kim, YJ1
Huh, I1
Kim, JY1
Park, S1
Ryu, SH1
Kim, KB1
Kim, S1
Park, T2
Kwon, O1
Lupp, A1
Karge, E1
Deufel, T1
Oelschlägers, H1
Fleck, C1
Alarcon-Aguilar, FJ2
Almanza-Perez, J1
Blancas, G1
Angeles, S1
Garcia-Macedo, R2
Roman, R1
Cruz, M2
Wu, L1
Yang, W1
Jia, X1
Yang, G1
Duridanova, D1
Cao, K1
Wang, R1
Ouederni, TB1
Sanchez-Corona, J1
Flores Martinez, SE1
Ben Maiz, H1
Skhiri, HA1
Abid, HK1
Benammar-Elgaaied, A1
Kim, SH1
Yang, SO1
Kim, HS1
Kim, Y1
Choi, HK1
Almanza-Perez, JC1
Blancas-Flores, G1
Campos-Sepulveda, AE1
Roman-Ramos, R1
Maarman, G1
Marais, E1
Lochner, A1
du Toit, EF1
Beadle, RM1
Yue, JT1
Mighiu, PI1
Naples, M1
Adeli, K1
Lam, TK1
Mencarelli, M1
Zulian, A1
Cancello, R1
Alberti, L1
Gilardini, L1
Di Blasio, AM1
Invitti, C1
Keung, W1
Ussher, JR1
Jaswal, JS1
Raubenheimer, M1
Lam, VH1
Wagg, CS1
Lopaschuk, GD1
Lees, HJ1
Swann, JR1
Wilson, ID1
Nicholson, JK1
Holmes, E1
Muller, YL1
Bogardus, C2
Pedersen, O1
Baier, L1
Sarich, TC1
Teng, R1
Peters, GR1
Wollbratt, M1
Homolka, R1
Svensson, M1
Eriksson, UG1
Stefan, N1
Kovacs, P1
Stumvoll, M1
Hanson, RL1
Lehn-Stefan, A1
Permana, PA1
Baier, LJ1
Tataranni, PA1
Silver, K1
Jellema, A1
Zeegers, MP1
Feskens, EJ1
Dagnelie, PC1
Mensink, RP1
HUGHES, AM1
TOLBERT, BM1
CRISTOFORI, FC1
DUNCAN, GG1
D'Adamo, M1
Perego, L1
Cardellini, M1
Marini, MA1
Frontoni, S1
Andreozzi, F1
Sciacqua, A1
Lauro, D1
Sbraccia, P1
Federici, M1
Paganelli, M1
Pontiroli, AE1
Lauro, R1
Perticone, F1
Folli, F1
Sesti, G1
Ramis, JM1
González-Sánchez, JL1
Proenza, AM1
Martínez-Larrad, MT1
Fernández-Pérez, C1
Palou, A1
Serrano-Ríos, M1
Nakashima, T1
Sumida, Y1
Mitsuyoshi, H1
Okanoue, T1
Bidzińska, B1
Demissie, M1
Tworowska, U1
Slezak, R1
Dobosz, T1
Milewicz, A1
Harrity, T1
Farrelly, D1
Tieman, A1
Chu, C1
Kunselman, L1
Gu, L1
Ponticiello, R1
Cap, M1
Qu, F1
Shao, C1
Wang, W1
Zhang, H1
Fenderson, W1
Chen, S1
Devasthale, P1
Jeon, Y1
Seethala, R1
Yang, WP1
Ren, J1
Zhou, M1
Ryono, D1
Biller, S1
Mookhtiar, KA1
Wetterau, J1
Gregg, R1
Cheng, PT1
Hariharan, N1
Fanelli, M1
Filippi, E1
Sentinelli, F1
Romeo, S1
Fallarino, M1
Buzzetti, R1
Leonetti, F1
Baroni, MG1
Ridderstråle, M1
Johansson, LE1
Rastam, L1
Lindblad, U1
Pyrzak, B1
Wiśniewska, A1
Rymkiewicz-Kluczyńska, B1
Masuo, K1
Katsuya, T1
Kawaguchi, H1
Fu, Y1
Rakugi, H1
Ogihara, T1
Tuck, ML1
Mo, W1
Zhang, GG1
Yang, TL1
Dai, XP1
Li, HH1
Zeng, H1
Liu, J1
Tan, YM1
Zhou, HH1
Liu, ZQ1
Peeters, A1
Beckers, S1
Mertens, I1
Van Hul, W1
Van Gaal, L1
Gougeon, R2
Morais, JA2
Chevalier, S1
Pereira, S1
Lamarche, M1
Marliss, EB2
von Studnitz, W1
Krag, E2
Højgaard, L1
Garlick, PJ1
Clugston, GA1
Waterlow, JC2
Winterer, J1
Bistrian, BR1
Bilmazes, C1
Blackburn, GL1
Young, VR1
Ivy, JL1
Cortez, MY1
Chandler, RM1
Byrne, HK1
Miller, RH1
Jones, PJ1
Pencharz, PB1
Krempler, F1
Hell, E1
Winkler, C1
Breban, D1
Patsch, W1
Ebbeling, CB1
Rodriguez, NR1
Mori, Y1
Kim-Motoyama, H1
Ito, Y1
Katakura, T1
Yasuda, K1
Ishiyama-Shigemoto, S1
Yamada, K1
Akanuma, Y1
Ohashi, Y1
Kimura, S1
Yazaki, Y1
Kadowaki, T1
Meirhaeghe, A1
Helbecque, N1
Cottel, D1
Amouyel, P1
Hayakawa, T1
Nagai, Y1
Kahara, T1
Yamashita, H1
Takamura, T1
Abe, T1
Nomura, G1
Kobayashi, K1
Marchini, JS1
Lambertini, CR1
Ferriolli, E1
Dutra de Oliveira, JE1
Faber, P1
Johnstone, AM1
Gibney, ER1
Elia, M1
Stubbs, RJ1
Duthie, GG1
Calder, AG1
Lobley, GE1
Dionne, IJ1
Garant, MJ1
Nolan, AA1
Pollin, TI1
Lewis, DG1
Shuldiner, AR1
Poehlman, ET1
Wise, L3
Stein, T3
Golden, MH1
Ell, MS1
Bruusgaard, A1
Sörensen, TI1
Justesen, T2
Müller, WA1
Aoki, TT1
Cahill, GF2
Margraf, H1
Oi, Y2
Okuda, T2
Miyoshi, H1
Koishi, H2
Koh, H1
Waki, M1
Kurata, M1
Nambu, S1
Danö, P2
Lenz, K2
Sherr, HP1
Nair, PP1
White, JJ2
Banwell, JG1
Lockwood, DH2
Halliday, D1
Garrow, JS1
Rodgers, PA1
Sehlin, J1
Gylfe, E1
Moxley, RT1
Pozefsky, T1
Deleña, S1
Brown, H1
Adibi, SA1
Felig, P1
Marliss, E1
Mandell, AJ1
Rubin, RT1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Controlled and Randomized Clinical Trial for Evaluating the Effect of a Supplement of Glycine as Adjuvant in the Treatment of COVID-19 Pneumonia in Patients Initiating Mechanical Ventilation[NCT04443673]59 participants (Actual)Interventional2020-06-15Terminated (stopped due to An interim analysis showed no difference in major outcomes (n=35 glycine and n=24 control participants))
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

9 reviews available for glycine and Obesity

ArticleYear
Effects of glycine on metabolic syndrome components: a review.
    Journal of endocrinological investigation, 2022, Volume: 45, Issue:5

    Topics: Exercise; Glycine; Humans; Life Style; Metabolic Syndrome; Obesity

2022
Alterations in glycine metabolism in obesity and chronic metabolic diseases - an update on new advances.
    Current opinion in clinical nutrition and metabolic care, 2023, 01-01, Volume: 26, Issue:1

    Topics: Amino Acids, Branched-Chain; Diet; Glycine; Humans; Insulin Resistance; Metabolic Diseases; Obesity

2023
Linking Metabolic Disease With the PGC-1α Gly482Ser Polymorphism.
    Endocrinology, 2018, 02-01, Volume: 159, Issue:2

    Topics: Amino Acid Substitution; Diabetes Mellitus, Type 2; Genetic Linkage; Genetic Predisposition to Disea

2018
Glycine Metabolism and Its Alterations in Obesity and Metabolic Diseases.
    Nutrients, 2019, Jun-16, Volume: 11, Issue:6

    Topics: Biological Availability; Diabetes Mellitus, Type 2; Diet; Gastrointestinal Microbiome; Glycine; Huma

2019
Hippurate: the natural history of a mammalian-microbial cometabolite.
    Journal of proteome research, 2013, Apr-05, Volume: 12, Issue:4

    Topics: Age Factors; Animals; Atherosclerosis; Autistic Disorder; Benzoic Acid; Diabetes Mellitus; Diet; Fem

2013
Gly972Arg variant in the insulin receptor substrate-1 gene and association with Type 2 diabetes: a meta-analysis of 27 studies.
    Diabetologia, 2003, Volume: 46, Issue:7

    Topics: Amino Acid Substitution; Arginine; Diabetes Mellitus; Diabetes Mellitus, Type 2; Genetic Carrier Scr

2003
[Treatment of nonalcoholic steatohepatitis (NASH)].
    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 2004, Volume: 101, Issue:11

    Topics: Cysteine; Diet; Drug Combinations; Fatty Liver; Glycine; Hepatitis; Humans; Insulin Resistance; Live

2004
Bile acid metabolism after intestinal bypass operations.
    International journal of obesity, 1981, Volume: 5, Issue:5

    Topics: Bile; Bile Acids and Salts; Glycine; Humans; Ileum; Jejunum; Kinetics; Obesity; Taurine

1981
Interactions between carbohydrate, protein, and fat metabolism in starvation.
    Nutrition reviews, 1969, Volume: 27, Issue:9

    Topics: Alanine; Amino Acids; Ammonia; Carbohydrate Metabolism; Gluconeogenesis; Glycerol; Glycine; Humans;

1969

Trials

5 trials available for glycine and Obesity

ArticleYear
Pilot Study Examining the Influence of Potassium Bicarbonate Supplementation on Nitrogen Balance and Whole-Body Ammonia and Urea Turnover Following Short-Term Energy Restriction in Older Men.
    Nutrients, 2018, May-16, Volume: 10, Issue:5

    Topics: Aged; Ammonia; Bicarbonates; Body Mass Index; Diet, Reducing; Dietary Supplements; Energy Intake; Gl

2018
Network Analysis of Metabolite GWAS Hits: Implication of CPS1 and the Urea Cycle in Weight Maintenance.
    PloS one, 2016, Volume: 11, Issue:3

    Topics: Adult; Ammonia; Betaine; Caloric Restriction; Carbamoyl-Phosphate Synthase (Ammonia); Carbamyl Phosp

2016
Integration of Traditional and Metabolomics Biomarkers Identifies Prognostic Metabolites for Predicting Responsiveness to Nutritional Intervention against Oxidative Stress and Inflammation.
    Nutrients, 2017, Mar-04, Volume: 9, Issue:3

    Topics: Adult; Biomarkers; Body Mass Index; Diet; Erythrocytes; Female; Glutathione; Glycine; Humans; Inflam

2017
No influence of obesity on the pharmacokinetics and pharmacodynamics of melagatran, the active form of the oral direct thrombin inhibitor ximelagatran.
    Clinical pharmacokinetics, 2003, Volume: 42, Issue:5

    Topics: Administration, Oral; Adult; Area Under Curve; Azetidines; Benzylamines; Female; Glycine; Half-Life;

2003
Obese women on a low energy rice and bean diet: effects of leucine, arginine or glycine supplementation on protein turnover.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2001, Volume: 34, Issue:10

    Topics: Adult; Amino Acids; Analysis of Variance; Arginine; Diet, Reducing; Dietary Proteins; Dietary Supple

2001

Other Studies

84 other studies available for glycine and Obesity

ArticleYear
Amino acid signatures in relation to polycystic ovary syndrome and increased risk of different metabolic disturbances.
    Reproductive biomedicine online, 2022, Volume: 44, Issue:4

    Topics: Alanine; Amino Acids; Body Mass Index; Female; Glycine; Humans; Insulin Resistance; Lysine; Metaboli

2022
BGM, a Newly Synthesised Boron Compound, Induces Apoptosis and Reduces Oxidative Stress by Inhibiting Lipogenesis in 3T3-L1 Adipocytes via PPARγ and CTRP3.
    Biological trace element research, 2022, Volume: 200, Issue:11

    Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; Alprostadil; Animals; Annexin A5; Antioxidants; Apoptosis; B

2022
Exposure to environmental pollutant bisphenol A causes oxidative damage and lipid accumulation in Zebrafish larvae: Protective role of WL15 peptide derived from cysteine and glycine-rich protein 2.
    Journal of biochemical and molecular toxicology, 2023, Volume: 37, Issue:1

    Topics: Animals; Antioxidants; Benzhydryl Compounds; Cysteine; Glutathione; Glycine; Humans; Larva; Obesity;

2023
Glycine-β-muricholic acid antagonizes the intestinal farnesoid X receptor-ceramide axis and ameliorates NASH in mice.
    Hepatology communications, 2022, Volume: 6, Issue:12

    Topics: Animals; Ceramides; Glycine; Intestines; Mice; Non-alcoholic Fatty Liver Disease; Obesity; Receptors

2022
Glycine Supplementation in Obesity Worsens Glucose Intolerance through Enhanced Liver Gluconeogenesis.
    Nutrients, 2022, Dec-24, Volume: 15, Issue:1

    Topics: Animals; Diet, High-Fat; Dietary Supplements; Gluconeogenesis; Glucose Intolerance; Glycine; Insulin

2022
Ghrelin Receptor Signaling Is Not Required for Glucocorticoid-Induced Obesity in Male Mice.
    Endocrinology, 2020, 03-01, Volume: 161, Issue:3

    Topics: Adiposity; Animals; Eating; Glucocorticoids; Glycine; Hippocampus; Male; Mice; Mice, Inbred C57BL; M

2020
Obesity increases hepatic glycine dehydrogenase and aminomethyltransferase expression while dietary glycine supplementation reduces white adipose tissue in Zucker diabetic fatty rats.
    Amino acids, 2020, Volume: 52, Issue:10

    Topics: Adipose Tissue, White; Alanine; Aminomethyltransferase; Animals; Appetite Regulation; Body Weight; D

2020
Muscle-Liver Trafficking of BCAA-Derived Nitrogen Underlies Obesity-Related Glycine Depletion.
    Cell reports, 2020, 11-10, Volume: 33, Issue:6

    Topics: Amino Acids, Branched-Chain; Animals; Glycine; Liver; Male; Muscle, Skeletal; Nitrogen; Obesity; Rat

2020
Circulating Metabolites Associated with Postprandial Satiety in Overweight/Obese Participants: The SATIN Study.
    Nutrients, 2021, Feb-08, Volume: 13, Issue:2

    Topics: Adult; Aged; Appetite Regulation; Area Under Curve; Cross-Sectional Studies; Double-Blind Method; Fa

2021
MCH-R1 Antagonist GPS18169, a Pseudopeptide, Is a Peripheral Anti-Obesity Agent in Mice.
    Molecules (Basel, Switzerland), 2021, Feb-27, Volume: 26, Issue:5

    Topics: Adipose Tissue; Alkynes; Aminobutyrates; Animals; Anti-Obesity Agents; Appetite; Aspartic Acid; Dise

2021
Dietary Supplementation with Glycine Enhances Intestinal Mucosal Integrity and Ameliorates Inflammation in C57BL/6J Mice with High-Fat Diet-Induced Obesity.
    The Journal of nutrition, 2021, 07-01, Volume: 151, Issue:7

    Topics: Animals; Diet, High-Fat; Dietary Supplements; Gastrointestinal Microbiome; Glycine; Inflammation; Ma

2021
Effect of vertical sleeve gastrectomy on alcohol consumption and preferences in dietary obese rats and mice: A plausible role for altered ghrelin signaling.
    Brain research bulletin, 2018, Volume: 138

    Topics: Alcohol Drinking; Analysis of Variance; Animals; Blood Glucose; Central Nervous System Depressants;

2018
EFFECTIVENESS OF NONALCOHOLIC STEATOHEPATITIS CORRECTION ON THE BAСKGROUND OF OBESITY WITH CONCOMITANT CHRONIC KIDNEY DISEASE.
    Georgian medical news, 2018, Issue:283

    Topics: Administration, Oral; Anti-Inflammatory Agents; Cysteine; Drug Administration Schedule; Drug Combina

2018
Neutrophil elastase inhibitor suppresses oxidative stress in obese asthmatic rats by activating Keap1/Nrf2 signaling pathway.
    European review for medical and pharmacological sciences, 2019, Volume: 23, Issue:1

    Topics: Animals; Antioxidants; Asthma; Disease Models, Animal; Glycine; Humans; Kelch-Like ECH-Associated Pr

2019
NMR-based metabolomics and breath studies show lipid and protein catabolism during low dose chronic T(1)AM treatment.
    Obesity (Silver Spring, Md.), 2013, Volume: 21, Issue:12

    Topics: 3-Hydroxybutyric Acid; Animals; Body Weight; Breath Tests; Dietary Proteins; Dose-Response Relations

2013
Increase or decrease hydrogen sulfide exert opposite lipolysis, but reduce global insulin resistance in high fatty diet induced obese mice.
    PloS one, 2013, Volume: 8, Issue:9

    Topics: Adipocytes; Alkynes; Animals; Blood Glucose; Carrier Proteins; Cystathionine gamma-Lyase; Cysteine;

2013
Status of selected nutrients in obese dogs undergoing caloric restriction.
    BMC veterinary research, 2013, Oct-24, Volume: 9

    Topics: Amino Acids; Animals; Caloric Restriction; Choline; Creatinine; Dog Diseases; Dogs; Female; Glycine;

2013
A circadian clock gene, Rev-erbα, modulates the inflammatory function of macrophages through the negative regulation of Ccl2 expression.
    Journal of immunology (Baltimore, Md. : 1950), 2014, Jan-01, Volume: 192, Issue:1

    Topics: Age Factors; Animals; Cell Adhesion; Cell Line; Cell Movement; Chemokine CCL2; Circadian Clocks; Gen

2014
Leptin-induced endothelium-dependent vasorelaxation of peripheral arteries in lean and obese rats: role of nitric oxide and hydrogen sulfide.
    PloS one, 2014, Volume: 9, Issue:1

    Topics: Adipose Tissue; Alkynes; Animals; Biological Factors; Bismuth; Cystathionine gamma-Lyase; Diet; Endo

2014
Scallop protein with endogenous high taurine and glycine content prevents high-fat, high-sucrose-induced obesity and improves plasma lipid profile in male C57BL/6J mice.
    Amino acids, 2014, Volume: 46, Issue:7

    Topics: Adipose Tissue; Animals; Diet, High-Fat; Dietary Proteins; Energy Intake; Glycine; Lipids; Male; Mic

2014
Pharmacological effects of JTT-551, a novel protein tyrosine phosphatase 1B inhibitor, in diet-induced obesity mice.
    Journal of diabetes research, 2014, Volume: 2014

    Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glu

2014
Pharmacological inhibition of FTO.
    PloS one, 2015, Volume: 10, Issue:4

    Topics: Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Animals; Anti-Obesity Agents; Cell Line; Drug Evaluat

2015
Glycine supplementation during calorie restriction accelerates fat loss and protects against further muscle loss in obese mice.
    Clinical nutrition (Edinburgh, Scotland), 2016, Volume: 35, Issue:5

    Topics: Animals; Body Composition; Body Mass Index; Caloric Restriction; Cytokines; Diet, High-Fat; Dietary

2016
Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction.
    Nature communications, 2015, Dec-15, Volume: 6

    Topics: Adolescent; Adult; Aged; Animals; Ceramides; Cholic Acids; Diet, High-Fat; Fatty Liver; Female; Glyc

2015
Bile Acid Metabolome after an Oral Lipid Tolerance Test by Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS).
    PloS one, 2016, Volume: 11, Issue:2

    Topics: Adolescent; Adult; Anthropometry; Bile Acids and Salts; Chromatography, Liquid; Contraceptives, Oral

2016
Hydrogen sulfide depletion contributes to microvascular remodeling in obesity.
    American journal of physiology. Heart and circulatory physiology, 2016, 05-01, Volume: 310, Issue:9

    Topics: Alkynes; Animals; Arterioles; Cells, Cultured; Collagen; Collagenases; Cystathionine gamma-Lyase; Di

2016
Effect of Glycine on Adipocyte Hypertrophy in a Metabolic Syndrome Rat Model.
    Current drug delivery, 2016, Volume: 13, Issue:1

    Topics: Adipocytes; Adipose Tissue; Animals; Blood Pressure; Fatty Acids; Glycine; Hypertrophy; Insulin; Lip

2016
Ciprofibrate, clofibric acid and respective glycinate derivatives. Effects of a four-week treatment on male lean and obese Zucker rats.
    Arzneimittel-Forschung, 2008, Volume: 58, Issue:5

    Topics: Animals; Body Weight; Chemical and Drug Induced Liver Injury; Clofibric Acid; Cytochrome P-450 Enzym

2008
Glycine regulates the production of pro-inflammatory cytokines in lean and monosodium glutamate-obese mice.
    European journal of pharmacology, 2008, Dec-03, Volume: 599, Issue:1-3

    Topics: 3T3 Cells; Adiponectin; Animals; Cytokines; Disease Models, Animal; Gene Expression Regulation; Gluc

2008
Pancreatic islet overproduction of H2S and suppressed insulin release in Zucker diabetic rats.
    Laboratory investigation; a journal of technical methods and pathology, 2009, Volume: 89, Issue:1

    Topics: Alkynes; Animals; Blood Glucose; Catalysis; Cystathionine gamma-Lyase; Diabetes Mellitus; Glycine; H

2009
The G1057D polymorphism of IRS-2 gene is not associated with type 2 diabetes and obese patients among ethnic groups in Tunisian population.
    Clinical biochemistry, 2009, Volume: 42, Issue:10-11

    Topics: Aspartic Acid; Black People; Diabetes Mellitus, Type 2; Ethnicity; Female; Genetic Predisposition to

2009
1H-nuclear magnetic resonance spectroscopy-based metabolic assessment in a rat model of obesity induced by a high-fat diet.
    Analytical and bioanalytical chemistry, 2009, Volume: 395, Issue:4

    Topics: Acetoacetates; Acetone; Animals; Betaine; Citric Acid; Dietary Fats; Disease Models, Animal; Glycine

2009
Glycine regulates inflammatory markers modifying the energetic balance through PPAR and UCP-2.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2010, Volume: 64, Issue:8

    Topics: Adipose Tissue; Animals; Anti-Inflammatory Agents; Cytokines; Disease Models, Animal; Energy Metabol

2010
Effect of chronic CPT-1 inhibition on myocardial ischemia-reperfusion injury (I/R) in a model of diet-induced obesity.
    Cardiovascular drugs and therapy, 2012, Volume: 26, Issue:3

    Topics: Animals; Body Weight; Carnitine O-Palmitoyltransferase; Diet; Disease Models, Animal; Enzyme Inhibit

2012
Reducing the burden of ischemia reperfusion: editorial to: "Effect of Chronic CPT-1 Inhibition on Myocardial Ischemia-Reperfusion Injury (I/R) in a Model of Diet-Induced Obesity" by G. Maarman et al.
    Cardiovascular drugs and therapy, 2012, Volume: 26, Issue:3

    Topics: Animals; Carnitine O-Palmitoyltransferase; Enzyme Inhibitors; Glycine; Male; Myocardial Infarction;

2012
Glycine normalizes hepatic triglyceride-rich VLDL secretion by triggering the CNS in high-fat fed rats.
    Circulation research, 2012, May-11, Volume: 110, Issue:10

    Topics: Adiponectin; Animals; Cholesterol, VLDL; Diabetes Mellitus, Type 2; Dietary Fats; Dyslipidemias; Fat

2012
A novel missense mutation in the signal peptide of the human POMC gene: a possible additional link between early-onset type 2 diabetes and obesity.
    European journal of human genetics : EJHG, 2012, Volume: 20, Issue:12

    Topics: Animals; Arginine; Cell Line, Tumor; Coronary Disease; Diabetes Mellitus, Type 2; Female; Genetic Lo

2012
Inhibition of carnitine palmitoyltransferase-1 activity alleviates insulin resistance in diet-induced obese mice.
    Diabetes, 2013, Volume: 62, Issue:3

    Topics: Animals; Anti-Obesity Agents; Carbohydrate Metabolism; Carnitine O-Palmitoyltransferase; Cell Membra

2013
A Gly482Ser missense mutation in the peroxisome proliferator-activated receptor gamma coactivator-1 is associated with altered lipid oxidation and early insulin secretion in Pima Indians.
    Diabetes, 2003, Volume: 52, Issue:3

    Topics: Adipocytes; Adipose Tissue; Adult; Alleles; Blood Glucose; Body Composition; Body Mass Index; Cell S

2003
Metabolic effects of the Gly1057Asp polymorphism in IRS-2 and interactions with obesity.
    Diabetes, 2003, Volume: 52, Issue:6

    Topics: Adult; Amino Acid Substitution; Animals; Arizona; Aspartic Acid; Base Sequence; Body Composition; Co

2003
Oxidation of acetate, glucose, or glycine to carbon dioxide in mice exhibiting the hereditary obesity syndrome.
    The Journal of biological chemistry, 1958, Volume: 231, Issue:1

    Topics: Acetates; Animals; Carbohydrate Metabolism; Carbon Dioxide; Glucose; Glycine; Mice; Obesity; Oxidati

1958
URIC ACID EXCRETION IN OBESE SUBJECTS DURING PERIODS OF TOTAL FASTING.
    Metabolism: clinical and experimental, 1964, Volume: 13

    Topics: Acidosis; Basal Metabolism; Blood Glucose; Fasting; Glycine; Humans; Obesity; Pennsylvania; Probenec

1964
The -866A/A genotype in the promoter of the human uncoupling protein 2 gene is associated with insulin resistance and increased risk of type 2 diabetes.
    Diabetes, 2004, Volume: 53, Issue:7

    Topics: Adipose Tissue; Adult; Alanine; Case-Control Studies; Diabetes Mellitus, Type 2; Female; Genotype; G

2004
The Arg64 allele of the beta 3-adrenoceptor gene but not the -3826G allele of the uncoupling protein 1 gene is associated with increased leptin levels in the Spanish population.
    Metabolism: clinical and experimental, 2004, Volume: 53, Issue:11

    Topics: Adipocytes; Adult; Alanine; Arginine; Blood Glucose; Body Mass Index; Carrier Proteins; Cholesterol;

2004
[Is obesity associated with a polymorphism Pro12Ala and Pro115Gln in the PPARgamma gene?].
    Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 2004, Volume: 17, Issue:100

    Topics: Alanine; Body Mass Index; Case-Control Studies; Female; Gene Frequency; Glycine; Humans; Male; Obesi

2004
Muraglitazar, a novel dual (alpha/gamma) peroxisome proliferator-activated receptor activator, improves diabetes and other metabolic abnormalities and preserves beta-cell function in db/db mice.
    Diabetes, 2006, Volume: 55, Issue:1

    Topics: Adiponectin; Animals; Blood Glucose; Corticosterone; Diabetes Mellitus, Type 2; Diet; Female; Glycin

2006
The Gly482Ser missense mutation of the peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1 alpha) gene associates with reduced insulin sensitivity in normal and glucose-intolerant obese subjects.
    Disease markers, 2005, Volume: 21, Issue:4

    Topics: Adult; Amino Acid Substitution; Female; Genetic Predisposition to Disease; Glucose Intolerance; Glyc

2005
Increased risk of obesity associated with the variant allele of the PPARGC1A Gly482Ser polymorphism in physically inactive elderly men.
    Diabetologia, 2006, Volume: 49, Issue:3

    Topics: Adult; Age Distribution; Aged; Alleles; Exercise; Female; Glycine; Heat-Shock Proteins; Humans; Leis

2006
[The influence of polymorphism the Gly972Arg variant insulin receptor substrate-1 (IRS-1) gene, and G-308A TNF-alpha gene on obesity and insulin resistance in children with obesity].
    Endokrynologia, diabetologia i choroby przemiany materii wieku rozwojowego : organ Polskiego Towarzystwa Endokrynologow Dzieciecych, 2006, Volume: 12, Issue:3

    Topics: Adolescent; Arginine; Child; Female; Gene Frequency; Glycine; Humans; Insulin Receptor Substrate Pro

2006
Beta2-adrenoceptor polymorphisms relate to obesity through blunted leptin-mediated sympathetic activation.
    American journal of hypertension, 2006, Volume: 19, Issue:10

    Topics: Adult; Alleles; Blood Pressure; Body Weight; Cohort Studies; Gene Expression Regulation; Gene Freque

2006
The genetic polymorphisms of beta3-adrenergic receptor (AR) Trp64Arg and beta2-AR Gln27Glu are associated with obesity in Chinese male hypertensive patients.
    Clinical chemistry and laboratory medicine, 2007, Volume: 45, Issue:4

    Topics: Aged; Arginine; Base Sequence; DNA Primers; Glutamic Acid; Glycine; Humans; Hypertension; Male; Midd

2007
The G1422A variant of the cannabinoid receptor gene (CNR1) is associated with abdominal adiposity in obese men.
    Endocrine, 2007, Volume: 31, Issue:2

    Topics: Abdominal Fat; Adiposity; Adult; Alanine; Case-Control Studies; Female; Glycine; Humans; Male; Middl

2007
Determinants of whole-body protein metabolism in subjects with and without type 2 diabetes.
    Diabetes care, 2008, Volume: 31, Issue:1

    Topics: Adult; Basal Metabolism; Body Weight; Diabetes Mellitus, Type 2; Female; Glycine; Humans; Kinetics;

2008
Urinary excretion of aminoacetone following administration of L-threonine in man.
    Scandinavian journal of clinical and laboratory investigation, 1967, Volume: 20, Issue:1

    Topics: Amino Acids; Creatinine; Dietary Carbohydrates; Electrophoresis; Glycine; Humans; Ketone Bodies; Lev

1967
Influence of low-energy diets on whole-body protein turnover in obese subjects.
    The American journal of physiology, 1980, Volume: 238, Issue:3

    Topics: Adult; Aged; Diet, Reducing; Dietary Proteins; Female; Glycine; Humans; Leucine; Male; Middle Aged;

1980
Whole body protein turnover, studied with 15N-glycine, and muscle protein breakdown in mildly obese subjects during a protein-sparing diet and a brief total fast.
    Metabolism: clinical and experimental, 1980, Volume: 29, Issue:6

    Topics: Adult; Dietary Proteins; Fasting; Female; Glycine; Humans; Kinetics; Methylhistidines; Muscle Protei

1980
Effects of pyruvate on the metabolism and insulin resistance of obese Zucker rats.
    The American journal of clinical nutrition, 1994, Volume: 59, Issue:2

    Topics: Analysis of Variance; Animals; Blood Glucose; Body Weight; Cholesterol; Energy Metabolism; Female; G

1994
Effect of exogenous insulin on protein metabolism with differing nonprotein energy intakes in Type 2 diabetes mellitus.
    International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 1998, Volume: 22, Issue:3

    Topics: Adult; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Type 2; Dietary Proteins; Energy Intake;

1998
Plasma leptin levels: interaction of obesity with a common variant of insulin receptor substrate-1.
    Arteriosclerosis, thrombosis, and vascular biology, 1998, Volume: 18, Issue:11

    Topics: Adult; Amino Acid Substitution; Arginine; Blood Glucose; Case-Control Studies; Codon; Female; Genoty

1998
Effects of reduced energy intake on protein utilization in obese children.
    Metabolism: clinical and experimental, 1998, Volume: 47, Issue:12

    Topics: Amino Acids; Basal Metabolism; Body Weight; Child; Creatinine; Diet; Energy Metabolism; Female; Glyc

1998
The Gln27Glu beta2-adrenergic receptor variant is associated with obesity due to subcutaneous fat accumulation in Japanese men.
    Biochemical and biophysical research communications, 1999, Apr-29, Volume: 258, Issue:1

    Topics: Adipose Tissue; Adult; Aged; Alleles; Blood Glucose; Blood Pressure; Gene Frequency; Glutamic Acid;

1999
Impact of polymorphisms of the human beta2-adrenoceptor gene on obesity in a French population.
    International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 2000, Volume: 24, Issue:3

    Topics: Adult; Arginine; Body Constitution; Body Mass Index; Body Weight; Female; France; Genotype; Glutamic

2000
Gln27Glu and Arg16Gly polymorphisms of the beta2-adrenergic receptor gene are not associated with obesity in Japanese men.
    Metabolism: clinical and experimental, 2000, Volume: 49, Issue:9

    Topics: Adult; Aged; Arginine; Codon; Gene Frequency; Glutamic Acid; Glutamine; Glycine; Heterozygote; Homoz

2000
The effect of rate of weight loss on erythrocyte glutathione concentration and synthesis in healthy obese men.
    Clinical science (London, England : 1979), 2002, Volume: 102, Issue:5

    Topics: Amino Acids; Anthropometry; Body Composition; Erythrocytes; Glutathione; Glycine; Humans; Lipids; Ma

2002
Association between obesity and a polymorphism in the beta(1)-adrenoceptor gene (Gly389Arg ADRB1) in Caucasian women.
    International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 2002, Volume: 26, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Alleles; Arginine; Body Mass Index; Body Weight; Energy Intake; Ener

2002
The effect of jejunoileal bypass on bile composition and the formation of billiary calculi.
    Annals of surgery, 1978, Volume: 187, Issue:1

    Topics: Adult; Bile; Cholelithiasis; Cholesterol; Follow-Up Studies; Glycine; Humans; Ileum; Jejunum; Micell

1978
The use of urinary ammonia as end-product in measurements of total protein turnover with 15N.
    The Proceedings of the Nutrition Society, 1977, Volume: 36, Issue:1

    Topics: Adult; Ammonia; Child; Glycine; Humans; Obesity; Proteins

1977
Bile acid metabolism after jejunoileal bypass operation for obesity.
    Scandinavian journal of gastroenterology, 1976, Volume: 11, Issue:8

    Topics: Bile Acids and Salts; Chenodeoxycholic Acid; Cholic Acids; Deoxycholic Acid; Duodenum; Glycine; Huma

1976
Effect of alanine and glycine on glucagon secretion in postabsorptive and fasting obese man.
    The Journal of clinical endocrinology and metabolism, 1975, Volume: 40, Issue:3

    Topics: Adolescent; Adult; Alanine; Blood Glucose; Fasting; Female; Glucagon; Glycine; Humans; Insulin; Male

1975
Studies on bile salt deconjugation following small bowel bypass procedures.
    Annals of surgery, 1975, Volume: 181, Issue:4

    Topics: Bile Acids and Salts; Carbon Dioxide; Carbon Radioisotopes; Evaluation Studies as Topic; Feces; Glyc

1975
Biliary and urinary calculi: pathogenesis following small bowel bypass for obesity.
    Archives of surgery (Chicago, Ill. : 1960), 1975, Volume: 110, Issue:8

    Topics: Adult; Bile; Bile Acids and Salts; Calcium; Cholelithiasis; Follow-Up Studies; Glycine; Humans; Inte

1975
Effects of restricted diet on protein metabolism measured by [15N]glycine in high-fat-diet-induced obese rats.
    Journal of nutritional science and vitaminology, 1987, Volume: 33, Issue:4

    Topics: Animals; Caseins; Diet, Reducing; Dietary Fats; Dietary Proteins; Energy Intake; Glycine; Male; Nitr

1987
Effects of low energy diets on protein metabolism studies with [15N]glycine in obese patients.
    Journal of nutritional science and vitaminology, 1987, Volume: 33, Issue:3

    Topics: Body Weight; Diet, Reducing; Energy Metabolism; Female; Glycine; Humans; Kinetics; Male; Middle Aged

1987
Bile acid metabolism and intestinal bacterial flora after three types of intestinal shunt operation for obesity.
    Scandinavian journal of gastroenterology, 1974, Volume: 9, Issue:8

    Topics: Adolescent; Adult; Bile Acids and Salts; Carbon Radioisotopes; Enterobacteriaceae; Female; Glycine;

1974
Bile acid metabolism and hepatic disease following small bowel bypass for obesity.
    The American journal of clinical nutrition, 1974, Volume: 27, Issue:12

    Topics: Adult; Bile; Bile Acids and Salts; Bilirubin; Chenodeoxycholic Acid; Cholic Acids; Deoxycholic Acid;

1974
Proceedings: A simple technique for the estimation of tissue protein turnover in man.
    The Proceedings of the Nutrition Society, 1974, Volume: 33, Issue:2

    Topics: Dietary Proteins; Energy Metabolism; Glycine; Humans; Nitrogen Isotopes; Obesity; Protein Biosynthes

1974
Transport and oxidation of glycine in mammalian pancreatic islets with reference to the mechanism of amino acid-induced insulin release.
    Hormones, 1972, Volume: 3, Issue:3

    Topics: Amino Acids; Animals; Autoradiography; Carbon Dioxide; Carbon Isotopes; Glycine; Hyperglycemia; In V

1972
Change of bile acid metabolism and absorption of vitamin B 12 after intestinal shunt operation in obesity. A comparison of three types of operation.
    Scandinavian journal of gastroenterology, 1974, Volume: 9, Issue:2

    Topics: Adolescent; Adult; Bacteroides; Bile Acids and Salts; Breath Tests; Carbon Dioxide; Carbon Radioisot

1974
Changes of free amino acids in pancreatic beta-cells after starvation and substrate deprivation.
    Acta endocrinologica, 1974, Volume: 75, Issue:1

    Topics: Alanine; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Carbon Radioisotopes; Chromatography,

1974
Transient kwaskiorkor: A cause of fatty liver following small bowel bypass.
    Surgery, 1974, Volume: 75, Issue:6

    Topics: Adult; Amino Acids; Body Weight; Dietary Carbohydrates; Dietary Proteins; Fatty Liver; Female; Glyci

1974
Effect of glycine loading on Delta-Aminolevulinic acid (ALA) and porphobilinogen (PBG) excretion during starvation.
    Metabolism: clinical and experimental, 1969, Volume: 18, Issue:11

    Topics: Adolescent; Adult; Amino Acids; Body Weight; Female; Glycine; Humans; Hydro-Lyases; Levulinic Acids;

1969
Influence of dietary deprivations on plasma concentration of free amino acids of man.
    Journal of applied physiology, 1968, Volume: 25, Issue:1

    Topics: Adolescent; Adult; Alanine; Amino Acids; Chromatography, Ion Exchange; Diet; Dietary Proteins; Femal

1968
Plasma amino acid levels and insulin secretion in obesity.
    The New England journal of medicine, 1969, Oct-09, Volume: 281, Issue:15

    Topics: Adolescent; Adult; Amino Acids; Blood Glucose; Fasting; Feedback; Female; Glucose; Glycine; Humans;

1969
Indolylacroyl glycine excretion in man.
    Life sciences, 1965, Volume: 4, Issue:17

    Topics: Acrylates; Chromatography, Paper; Glycine; Humans; In Vitro Techniques; Indoles; Infrared Rays; Ment

1965