glycine has been researched along with Nerve Degeneration in 63 studies
Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Here we investigated for the first time the inhibitory potential of Glycine (Gly) against ethanol-induced oxidative stress, neuroinflammation and apoptotic neurodegeneration in human neuroblastoma SH-SY5Y cells and in the developing rat brain." | 7.83 | Glycine inhibits ethanol-induced oxidative stress, neuroinflammation and apoptotic neurodegeneration in postnatal rat brain. ( Amin, FU; Kim, MO; Shah, SA, 2016) |
| "The neuroprotective potential of an antagonist (7-chlorokynurenic acid (7-CIKYNA)) and a low efficacy partial agonist (HA-966) for the glycine modulatory site on the N-methyl-D-aspartate (NMDA) receptor complex has been examined using a neuronal cell culture/hypoxia model of neurodegeneration." | 7.68 | The effect of NMDA receptor glycine site antagonists on hypoxia-induced neurodegeneration of rat cortical cell cultures. ( Horne, AL; Kemp, JA; McKernan, RM; Priestley, T, 1990) |
| "Here we investigated for the first time the inhibitory potential of Glycine (Gly) against ethanol-induced oxidative stress, neuroinflammation and apoptotic neurodegeneration in human neuroblastoma SH-SY5Y cells and in the developing rat brain." | 3.83 | Glycine inhibits ethanol-induced oxidative stress, neuroinflammation and apoptotic neurodegeneration in postnatal rat brain. ( Amin, FU; Kim, MO; Shah, SA, 2016) |
| " The aminothiol compound cysteamine (CSH) induces the appearance of autofluorescent, iron-rich cytoplasmic granules in cultured astroglia that are identical to glial inclusions that progressively accumulate in the aging periventricular brain." | 3.69 | A cellular stress model for the sequestration of redox-active glial iron in the aging and degenerating nervous system. ( Manganaro, F; Schipper, HM; Wang, X, 1995) |
| "The neuroprotective potential of an antagonist (7-chlorokynurenic acid (7-CIKYNA)) and a low efficacy partial agonist (HA-966) for the glycine modulatory site on the N-methyl-D-aspartate (NMDA) receptor complex has been examined using a neuronal cell culture/hypoxia model of neurodegeneration." | 3.68 | The effect of NMDA receptor glycine site antagonists on hypoxia-induced neurodegeneration of rat cortical cell cultures. ( Horne, AL; Kemp, JA; McKernan, RM; Priestley, T, 1990) |
| "Peripheral nerve injury affects motor functions." | 1.72 | Slow progression of sciatic nerve degeneration and regeneration after loose ligation through microglial activation and decreased KCC2 levels in the mouse spinal cord ventral horn. ( Kim, J; Kinjo, D; Kobayashi, S; Kosaka, Y; Matsuda, K; Okabe, A; Okura, N; Shimizu-Okabe, C; Takayama, C; Yafuso, T, 2022) |
| " Agonists of the glycine recognition site of NMDA receptors (D-serine and D-alanine) did not have any toxic effect in hippocampal cultures, whereas competitive blockade of the glycine site by 7-chlorokynurenic acid was neuroprotective." | 1.33 | Glycine-induced neurotoxicity in organotypic hippocampal slice cultures. ( Barth, A; Barth, L; Newell, DW; Nguyen, LB, 2005) |
| " A dose-response study demonstrated that doses of DCG-IV as low as 5 nmol was very toxic in terms GAD mRNA and apoptosis." | 1.31 | DCG-IV but not other group-II metabotropic receptor agonists induces microglial BDNF mRNA expression in the rat striatum. Correlation with neuronal injury. ( Cano, J; Machado, A; Matarredona, ER; Santiago, M; Tomás-Camardiel, M; Venero, JL, 2002) |
| " In mixed cultures of cortical cells, the selective mGlu1/5 agonist, 3,5-dihydroxyphenylglycine (DHPG), amplified neurodegeneration induced by a toxic pulse of NMDA." | 1.31 | An activity-dependent switch from facilitation to inhibition in the control of excitotoxicity by group I metabotropic glutamate receptors. ( Battaglia, G; Bruno, V; Ceña, V; Cespédes, VM; Copani, A; Flor, PJ; Galindo, MF; Gasparini, F; Kuhn, R; Nicoletti, F; Sánchez-Prieto, J, 2001) |
| " LY354740 and LY379268 were protective against transient global ischemia in gerbils when dosed intraperitoneally." | 1.30 | Neuroprotective actions of novel and potent ligands of group I and group II metabotropic glutamate receptors. ( Battaglia, G; Bond, A; Bruno, V; Clark, BP; Harris, JR; Kingston, AE; Lodge, D; Monn, JA; Nicoletti, F; O'Neill, MJ; Schoepp, DD, 1999) |
| " Dose-response showed that DL-(tetrazol-5-yl)glycine was about 100 and 500 times more potent than cis-methanoglutamate and NMDA, respectively." | 1.29 | The NMDA receptor agonist DL-(tetrazol-5-yl)glycine is a highly potent excitotoxin. ( Lunn, WH; McDonald, JW; Salhoff, CR; Schoepp, DD, 1994) |
| "Glycine change was primarily limited to a bilateral decrease in the dorsal part of the lateral vestibular nucleus." | 1.29 | Quantitative changes of amino acid distributions in the rat vestibular nuclear complex after unilateral vestibular ganglionectomy. ( Godfrey, DA; Godfrey, TG; Li, H; Rubin, AM, 1996) |
| "Glycine levels were reduced by 9% in dorsolateral laminae VII and IX." | 1.27 | Amino acid levels in the guinea pig spinal gray matter after axotomy of primary sensory and descending tracts. ( Dymczyk, L; Potashner, SJ, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (15.87) | 18.7374 |
| 1990's | 21 (33.33) | 18.2507 |
| 2000's | 20 (31.75) | 29.6817 |
| 2010's | 9 (14.29) | 24.3611 |
| 2020's | 3 (4.76) | 2.80 |
| Authors | Studies |
|---|---|
| Sonobe, Y | 1 |
| Aburas, J | 1 |
| Krishnan, G | 1 |
| Fleming, AC | 1 |
| Ghadge, G | 1 |
| Islam, P | 1 |
| Warren, EC | 1 |
| Gu, Y | 1 |
| Kankel, MW | 1 |
| Brown, AEX | 1 |
| Kiskinis, E | 1 |
| Gendron, TF | 1 |
| Gao, FB | 1 |
| Roos, RP | 1 |
| Kratsios, P | 1 |
| Yafuso, T | 1 |
| Kosaka, Y | 1 |
| Shimizu-Okabe, C | 1 |
| Okura, N | 1 |
| Kobayashi, S | 1 |
| Kim, J | 2 |
| Matsuda, K | 1 |
| Kinjo, D | 1 |
| Okabe, A | 1 |
| Takayama, C | 2 |
| Escande-Beillard, N | 1 |
| Loh, A | 1 |
| Saleem, SN | 1 |
| Kanata, K | 1 |
| Hashimoto, Y | 1 |
| Altunoglu, U | 1 |
| Metoska, A | 1 |
| Grandjean, J | 1 |
| Ng, FM | 1 |
| Pomp, O | 1 |
| Baburajendran, N | 1 |
| Wong, J | 1 |
| Hill, J | 1 |
| Beillard, E | 1 |
| Cozzone, P | 1 |
| Zaki, M | 1 |
| Kayserili, H | 1 |
| Hamada, H | 1 |
| Shiratori, H | 1 |
| Reversade, B | 1 |
| Li, H | 2 |
| Zhang, N | 1 |
| Sun, G | 1 |
| Ding, S | 1 |
| Martin, DD | 1 |
| Hayden, MR | 1 |
| Slikker, W | 1 |
| Liu, F | 1 |
| Rainosek, SW | 1 |
| Patterson, TA | 1 |
| Sadovova, N | 1 |
| Hanig, JP | 1 |
| Paule, MG | 1 |
| Wang, C | 1 |
| Amin, FU | 1 |
| Shah, SA | 1 |
| Kim, MO | 1 |
| Liu, J | 1 |
| Tang, TS | 1 |
| Tu, H | 1 |
| Nelson, O | 1 |
| Herndon, E | 1 |
| Huynh, DP | 1 |
| Pulst, SM | 1 |
| Bezprozvanny, I | 1 |
| Ng, CH | 1 |
| Mok, SZ | 1 |
| Koh, C | 1 |
| Ouyang, X | 1 |
| Fivaz, ML | 1 |
| Tan, EK | 1 |
| Dawson, VL | 1 |
| Dawson, TM | 1 |
| Yu, F | 1 |
| Lim, KL | 1 |
| Negga, R | 2 |
| Rudd, DA | 1 |
| Davis, NS | 1 |
| Justice, AN | 1 |
| Hatfield, HE | 1 |
| Valente, AL | 1 |
| Fields, AS | 1 |
| Fitsanakis, VA | 2 |
| Stuart, JA | 1 |
| Machen, ML | 1 |
| Salva, J | 1 |
| Lizek, AJ | 1 |
| Richardson, SJ | 1 |
| Osborne, AS | 1 |
| Mirallas, O | 1 |
| McVey, KA | 1 |
| Tatetsu, M | 1 |
| Kina, S | 1 |
| Sunakawa, H | 1 |
| Wang, JW | 2 |
| Wang, HD | 2 |
| Zhong, WZ | 1 |
| Li, N | 1 |
| Cong, ZX | 2 |
| Zhang, XS | 1 |
| Zhou, XM | 1 |
| Zhang, DD | 1 |
| Valerio, A | 2 |
| Ferrario, M | 1 |
| Paterlini, M | 1 |
| Liberini, P | 1 |
| Moretto, G | 1 |
| Cairns, NJ | 1 |
| Pizzi, M | 2 |
| Spano, P | 1 |
| Venero, JL | 1 |
| Santiago, M | 1 |
| Tomás-Camardiel, M | 1 |
| Matarredona, ER | 1 |
| Cano, J | 1 |
| Machado, A | 1 |
| Belmadani, A | 1 |
| Neafsey, EJ | 1 |
| Collins, MA | 1 |
| Heresco-Levy, U | 1 |
| Barth, A | 1 |
| Nguyen, LB | 1 |
| Barth, L | 1 |
| Newell, DW | 1 |
| Petrović, M | 1 |
| Horák, M | 1 |
| Sedlácek, M | 1 |
| Vyklický, L | 1 |
| Fei, Z | 1 |
| Zhang, X | 1 |
| Bai, HM | 1 |
| Jiang, XF | 1 |
| Wang, XL | 1 |
| Vernon, AC | 1 |
| Zbarsky, V | 1 |
| Datla, KP | 1 |
| Croucher, MJ | 1 |
| Dexter, DT | 1 |
| Trauner, DA | 1 |
| Page, T | 1 |
| Greco, C | 1 |
| Sweetman, L | 1 |
| Kulovich, S | 1 |
| Nyhan, WL | 1 |
| Copani, A | 2 |
| Bruno, V | 4 |
| Battaglia, G | 4 |
| Leanza, G | 1 |
| Pellitteri, R | 1 |
| Russo, A | 1 |
| Stanzani, S | 1 |
| Nicoletti, F | 4 |
| Shinozaki, H | 2 |
| Hartmann, J | 1 |
| Ransmayr, G | 1 |
| Riederer, P | 1 |
| Wang, X | 1 |
| Manganaro, F | 1 |
| Schipper, HM | 1 |
| Fedele, E | 1 |
| Foster, AC | 2 |
| Ludolph, AC | 1 |
| Riepe, M | 1 |
| Ullrich, K | 1 |
| Wickesberg, RE | 1 |
| Whitlon, D | 1 |
| Oertel, D | 1 |
| Schoepp, DD | 2 |
| Lunn, WH | 1 |
| Salhoff, CR | 1 |
| McDonald, JW | 1 |
| Chandler, LJ | 1 |
| Sumners, C | 1 |
| Crews, FT | 1 |
| Godfrey, TG | 1 |
| Godfrey, DA | 1 |
| Rubin, AM | 1 |
| Kwak, S | 1 |
| Miyamoto, M | 1 |
| Ishida, M | 1 |
| Fletcher, EL | 1 |
| Kalloniatis, M | 1 |
| Bäurle, J | 1 |
| Grüsser-Cornehls, U | 1 |
| Tomiyama, M | 1 |
| Kannari, K | 1 |
| Matsunaga, M | 1 |
| Suneja, SK | 1 |
| Potashner, SJ | 2 |
| Benson, CG | 1 |
| Kingston, AE | 1 |
| O'Neill, MJ | 2 |
| Bond, A | 1 |
| Harris, JR | 1 |
| Clark, BP | 1 |
| Monn, JA | 1 |
| Lodge, D | 1 |
| Benarese, M | 1 |
| Boroni, F | 1 |
| Goffi, F | 1 |
| Spano, PF | 1 |
| Ksiazek, I | 1 |
| van der Putten, H | 1 |
| Catania, MV | 1 |
| Giuffrida, R | 1 |
| Lukic, S | 1 |
| Leonhardt, T | 1 |
| Inderbitzin, W | 1 |
| Gasparini, F | 2 |
| Kuhn, R | 2 |
| Hampson, DR | 1 |
| Flor, PJ | 2 |
| Rozza, A | 1 |
| Masoero, E | 1 |
| Favalli, L | 1 |
| Lanza, E | 1 |
| Govoni, S | 1 |
| Rizzo, V | 1 |
| Montalbetti, L | 1 |
| Ooboshi, H | 1 |
| Ibayashi, S | 1 |
| Takano, K | 1 |
| Sadoshima, S | 1 |
| Kondo, A | 1 |
| Uchimura, H | 1 |
| Fujishima, M | 1 |
| Yang, L | 1 |
| Zhang, B | 1 |
| Toku, K | 1 |
| Maeda, N | 1 |
| Sakanaka, M | 1 |
| Tanaka, J | 1 |
| Cespédes, VM | 1 |
| Galindo, MF | 1 |
| Ceña, V | 1 |
| Sánchez-Prieto, J | 1 |
| Zwienenberg, M | 1 |
| Gong, QZ | 1 |
| Berman, RF | 1 |
| Muizelaar, JP | 1 |
| Lyeth, BG | 1 |
| Mishra, OP | 1 |
| Delivoria-Papadopoulos, M | 1 |
| Santer, RM | 1 |
| Dering, MA | 1 |
| Ranson, RN | 1 |
| Waboso, HN | 1 |
| Watson, AH | 1 |
| Collins, GG | 1 |
| Boehme, DH | 1 |
| Marks, N | 1 |
| Fordice, MW | 1 |
| Plaitakis, A | 1 |
| McNamara, D | 1 |
| Dingledine, R | 1 |
| Priestley, T | 2 |
| Horne, AL | 1 |
| McKernan, RM | 1 |
| Kemp, JA | 2 |
| Donald, AE | 1 |
| Willis, CL | 1 |
| Tridgett, R | 1 |
| Phelix, CF | 1 |
| Hartle, DK | 1 |
| Shalaby, I | 1 |
| Chenard, B | 1 |
| Prochniak, M | 1 |
| Dymczyk, L | 1 |
| McBride, WJ | 1 |
| Ghetti, B | 1 |
| Takemura, M | 2 |
| Sugimoto, T | 2 |
| Sakai, A | 2 |
| Okubo, J | 1 |
| Roberts, PJ | 1 |
| Keen, P | 1 |
| Kozik, M | 1 |
5 reviews available for glycine and Nerve Degeneration
| Article | Year |
|---|---|
Glutamatergic neurotransmission modulation and the mechanisms of antipsychotic atypicality.
Topics: Animals; Antipsychotic Agents; Aspartic Acid; Glutamic Acid; Glycine; Humans; Nerve Degeneration; Ne | 2003 |
Physiology and pathology of NMDA receptors.
Topics: Animals; Brain; Glutamic Acid; Glycine; Humans; Ion Channels; Nerve Degeneration; Oxidation-Reductio | 2005 |
Excitotoxicity, energy metabolism and neurodegeneration.
Topics: Amino Acid Metabolism, Inborn Errors; Amino Acids; Animals; Energy Metabolism; Glycine; Humans; Nerv | 1993 |
Altered glutamatergic mechanisms and selective motor neuron degeneration in amyotrophic lateral sclerosis: possible role of glycine.
Topics: Amyotrophic Lateral Sclerosis; Animals; Glutamates; Glutamic Acid; Glutamine; Glycine; Humans; Motor | 1991 |
The glycine site on the NMDA receptor: pharmacology and involvement in NMDA receptor-mediated neurodegeneration.
Topics: Allosteric Site; Animals; Glycine; Kynurenic Acid; Nerve Degeneration; Receptors, N-Methyl-D-Asparta | 1990 |
58 other studies available for glycine and Nerve Degeneration
| Article | Year |
|---|---|
A C. elegans model of C9orf72-associated ALS/FTD uncovers a conserved role for eIF2D in RAN translation.
Topics: Alanine; Amyotrophic Lateral Sclerosis; Animals; Arginine; C9orf72 Protein; Caenorhabditis elegans; | 2021 |
Slow progression of sciatic nerve degeneration and regeneration after loose ligation through microglial activation and decreased KCC2 levels in the mouse spinal cord ventral horn.
Topics: Animals; Choline O-Acetyltransferase; gamma-Aminobutyric Acid; Glycine; K Cl- Cotransporters; Mice; | 2022 |
Loss of PYCR2 Causes Neurodegeneration by Increasing Cerebral Glycine Levels via SHMT2.
Topics: Adolescent; Animals; Cerebral Cortex; Child, Preschool; Female; Glycine; Glycine Hydroxymethyltransf | 2020 |
Inhibition of the group I mGluRs reduces acute brain damage and improves long-term histological outcomes after photothrombosis-induced ischaemia.
Topics: Animals; Antimetabolites, Antineoplastic; Astrocytes; Benzoates; Blotting, Western; Brain; Brain Isc | 2013 |
Post-translational myristoylation at the cross roads of cell death, autophagy and neurodegeneration.
Topics: Autophagy; Cell Death; Cell Differentiation; Cell Survival; Glycine; Humans; Myristic Acid; Nerve De | 2015 |
Ketamine-Induced Toxicity in Neurons Differentiated from Neural Stem Cells.
Topics: Animals; Apoptosis; Astrocytes; Calcium; Cell Division; Cells, Cultured; Cerebral Cortex; Culture Me | 2015 |
Glycine inhibits ethanol-induced oxidative stress, neuroinflammation and apoptotic neurodegeneration in postnatal rat brain.
Topics: Animals; Animals, Newborn; Apoptosis; Brain; Cell Line, Tumor; Dose-Response Relationship, Drug; Eth | 2016 |
Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 2.
Topics: Animals; Ataxins; Calcium; Calcium Channel Blockers; Calcium Signaling; Cell Death; Cells, Cultured; | 2009 |
Parkin protects against LRRK2 G2019S mutant-induced dopaminergic neurodegeneration in Drosophila.
Topics: Amino Acid Substitution; Animals; Animals, Genetically Modified; Dopamine; Drosophila; Drosophila Pr | 2009 |
Exposure to Mn/Zn ethylene-bis-dithiocarbamate and glyphosate pesticides leads to neurodegeneration in Caenorhabditis elegans.
Topics: Analysis of Variance; Animals; Animals, Genetically Modified; Caenorhabditis elegans; Dose-Response | 2011 |
Exposure to glyphosate- and/or Mn/Zn-ethylene-bis-dithiocarbamate-containing pesticides leads to degeneration of γ-aminobutyric acid and dopamine neurons in Caenorhabditis elegans.
Topics: Animals; Animals, Genetically Modified; Caenorhabditis elegans; Dopaminergic Neurons; Dose-Response | 2012 |
GABA/glycine signaling during degeneration and regeneration of mouse hypoglossal nerves.
Topics: Animals; Carrier Proteins; Cholera Toxin; Choline O-Acetyltransferase; gamma-Aminobutyric Acid; Gene | 2012 |
Expression and cell distribution of metabotropic glutamate receptor 5 in the rat cortex following traumatic brain injury.
Topics: Animals; Brain Injuries; Cerebral Cortex; Excitatory Amino Acid Agonists; Glycine; Male; Nerve Degen | 2012 |
Activation of metabotropic glutamate receptor 5 reduces the secondary brain injury after traumatic brain injury in rats.
Topics: Animals; Brain Edema; Brain Injuries; Excitatory Amino Acid Agonists; Glycine; Male; Microglia; Nerv | 2013 |
Spinal cord mGlu1a receptors: possible target for amyotrophic lateral sclerosis therapy.
Topics: Amyotrophic Lateral Sclerosis; Animals; Cell Survival; Excitatory Amino Acid Agonists; Excitatory Am | 2002 |
DCG-IV but not other group-II metabotropic receptor agonists induces microglial BDNF mRNA expression in the rat striatum. Correlation with neuronal injury.
Topics: Animals; Brain-Derived Neurotrophic Factor; Corpus Striatum; Cyclopropanes; DNA Fragmentation; Dose- | 2002 |
Human immunodeficiency virus type 1 gp120 and ethanol coexposure in rat organotypic brain slice cultures: Curtailment of gp120-induced neurotoxicity and neurotoxic mediators by moderate but not high ethanol concentrations.
Topics: Animals; Arachidonic Acid; Brain; Central Nervous System Depressants; Dose-Response Relationship, Dr | 2003 |
Glycine-induced neurotoxicity in organotypic hippocampal slice cultures.
Topics: Alanine; Animals; Animals, Newborn; Brain Ischemia; Dose-Response Relationship, Drug; Drug Resistanc | 2005 |
Metabotropic glutamate receptor antagonists and agonists: potential neuroprotectors in diffuse brain injury.
Topics: Animals; Body Water; Brain; Brain Edema; Cell Death; Cyclopropanes; Diffuse Axonal Injury; Disease M | 2006 |
Subtype selective antagonism of substantia nigra pars compacta Group I metabotropic glutamate receptors protects the nigrostriatal system against 6-hydroxydopamine toxicity in vivo.
Topics: Animals; Benzoates; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Excitatory Amino Ac | 2007 |
Progressive neurodegenerative disorder in a patient with nonketotic hyperglycinemia.
Topics: Amino Acid Metabolism, Inborn Errors; Central Nervous System Diseases; Cerebral Cortex; Female; Glyc | 1981 |
Activation of metabotropic glutamate receptors protects cultured neurons against apoptosis induced by beta-amyloid peptide.
Topics: Aminobutyrates; Amyloid beta-Peptides; Animals; Apoptosis; Benzoates; Calcium Channels; Cells, Cultu | 1995 |
Neuron damage induced by some potent kainoids and neuroprotective action of new agonists for metabotropic glutamate receptors.
Topics: Amino Acids, Dicarboxylic; Animals; Animals, Newborn; Brain; Culture Techniques; Cyclopropanes; Dose | 1994 |
The glycine binding site of the NMDA receptor: involvement in neurodegeneration and new approach for neuroprotection.
Topics: Autoradiography; Binding Sites; Binding, Competitive; Glycine; Hippocampus; Humans; In Vitro Techniq | 1994 |
A cellular stress model for the sequestration of redox-active glial iron in the aging and degenerating nervous system.
Topics: Aging; Aminolevulinic Acid; Animals; Astrocytes; Cysteamine; Glycine; Heme; Heme Oxygenase (Decycliz | 1995 |
An evaluation of the role of extracellular amino acids in the delayed neurodegeneration induced by quinolinic acid in the rat striatum.
Topics: Amino Acids; Animals; Asparagine; Aspartic Acid; Corpus Striatum; Dialysis; Dizocilpine Maleate; Glu | 1993 |
In vitro modulation of somatic glycine-like immunoreactivity in presumed glycinergic neurons.
Topics: Animals; Brain Chemistry; Cochlear Nucleus; Colchicine; Electric Stimulation; Glycine; Immunohistoch | 1994 |
The NMDA receptor agonist DL-(tetrazol-5-yl)glycine is a highly potent excitotoxin.
Topics: Animals; Animals, Newborn; Brain; Choline O-Acetyltransferase; Female; gamma-Aminobutyric Acid; Glut | 1994 |
Ethanol inhibits NMDA receptor-mediated excitotoxicity in rat primary neuronal cultures.
Topics: Animals; Brain; Cells, Cultured; Ethanol; Female; Glycine; L-Lactate Dehydrogenase; N-Methylaspartat | 1993 |
Quantitative changes of amino acid distributions in the rat vestibular nuclear complex after unilateral vestibular ganglionectomy.
Topics: Amino Acids; Animals; Aspartic Acid; Behavior, Animal; gamma-Aminobutyric Acid; Ganglionectomy; Glut | 1996 |
Neurotoxicity of (2S,1'R,2'R,3'R)-2-(2,3-dicarboxycyclopropyl)glycine, a potent agonist for class II metabotropic glutamate receptors, in the rat.
Topics: Animals; Behavior, Animal; Brain; Cyclopropanes; Dose-Response Relationship, Drug; Glycine; Hippocam | 1996 |
Neurochemical architecture of the normal and degenerating rat retina.
Topics: Amino Acids; Animals; Antibody Specificity; Arginine; Aspartic Acid; Autoradiography; gamma-Aminobut | 1996 |
Differential number of glycine- and GABA-immunopositive neurons and terminals in the deep cerebellar nuclei of normal and Purkinje cell degeneration mutant mice.
Topics: Animals; Cerebellar Nuclei; gamma-Aminobutyric Acid; Glycine; Immunohistochemistry; Mice; Mice, Neur | 1997 |
Strychnine-sensitive and strychnine-insensitive glycine binding sites in the spinal cord of the wobbler mouse.
Topics: Animals; Disease Models, Animal; Female; Glycine; Male; Mice; Mice, Neurologic Mutants; Motor Neuron | 1997 |
Plastic changes in glycine and GABA release and uptake in adult brain stem auditory nuclei after unilateral middle ear ossicle removal and cochlear ablation.
Topics: Age Factors; Animals; Auditory Pathways; Carbon Radioisotopes; Cochlea; Cochlear Nerve; Cochlear Nuc | 1998 |
Neuroprotective actions of novel and potent ligands of group I and group II metabotropic glutamate receptors.
Topics: Animals; Benzoates; Bridged Bicyclo Compounds; Cells, Cultured; Cerebral Cortex; Drug Evaluation, Pr | 1999 |
Neuroprotection by metabotropic glutamate receptor agonists on kainate-induced degeneration of motor neurons in spinal cord slices from adult rat.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Benzoates; Cell Survival; Choline O-Acetyltransferase | 2000 |
Selective activation of mGlu4 metabotropic glutamate receptors is protective against excitotoxic neuronal death.
Topics: Aminobutyrates; Animals; Cells, Cultured; Cerebral Cortex; Excitatory Amino Acid Agonists; Glutamic | 2000 |
Influence of different anaesthetics on extracellular aminoacids in rat brain.
Topics: Amino Acids; Anesthetics; Animals; Aspartic Acid; Brain; Brain Chemistry; Brain Ischemia; Extracellu | 2000 |
Hypothermia inhibits ischemia-induced efflux of amino acids and neuronal damage in the hippocampus of aged rats.
Topics: Aging; Alanine; Amino Acids; Animals; Aspartic Acid; Brain Ischemia; Cerebrovascular Circulation; Ex | 2000 |
Improvement of the viability of cultured rat neurons by the non-essential amino acids L-serine and glycine that upregulates expression of the anti-apoptotic gene product Bcl-w.
Topics: Animals; Apoptosis; bcl-X Protein; Cell Survival; Cells, Cultured; Cerebral Cortex; Coloring Agents; | 2000 |
Pharmacology and neuroprotective actions of mGlu receptor ligands.
Topics: Amino Acids; Brain; Brain Ischemia; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocycl | 2001 |
An activity-dependent switch from facilitation to inhibition in the control of excitotoxicity by group I metabotropic glutamate receptors.
Topics: Animals; Cells, Cultured; Cerebral Cortex; Enzyme Activation; Excitatory Amino Acid Agonists; Excita | 2001 |
The effect of groups II and III metabotropic glutamate receptor activation on neuronal injury in a rodent model of traumatic brain injury.
Topics: Animals; Brain Injuries; Cyclopropanes; Dose-Response Relationship, Drug; Fluorescent Dyes; Glycine; | 2001 |
Nitric oxide-mediated Ca++-influx in neuronal nuclei and cortical synaptosomes of normoxic and hypoxic newborn piglets.
Topics: Adenosine Triphosphate; Animals; Asphyxia Neonatorum; Calcium; Calcium Signaling; Cell Nucleus; Cere | 2002 |
Differential susceptibility to ageing of rat preganglionic neurones projecting to the major pelvic ganglion and of their afferent inputs.
Topics: Afferent Pathways; Aging; Animals; Dendrites; Disease Susceptibility; Efferent Pathways; gamma-Amino | 2002 |
Effect of chronic bulbectomy on the depth distribution of amino acid transmitter candidates in rat olfactory cortex.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Cerebral Cortex; Denervation; gamma-Aminobutyric Acid; | 1979 |
Glycine levels in the degenerated human spinal cord.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Glycine; Humans; Middle Aged; Nerve Degeneration; Spinal | 1976 |
Dual effect of glycine on NMDA-induced neurotoxicity in rat cortical cultures.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cells, Cultured; Cerebral Cortex; Drug Synergism; gamma-Aminob | 1990 |
The effect of NMDA receptor glycine site antagonists on hypoxia-induced neurodegeneration of rat cortical cell cultures.
Topics: Animals; Binding Sites; Cells, Cultured; Cerebral Cortex; Dizocilpine Maleate; Fetus; Glycine; Hypox | 1990 |
Systemic glutamate induces degeneration of a subpopulation of serotonin-immunoreactive neurons in the area postrema of rats.
Topics: Animals; Cerebral Ventricles; Glycine; Immunoenzyme Techniques; Male; Nerve Degeneration; Neurons; R | 1990 |
Glycine reverses 7-Cl kynurenate blockade of glutamate neurotoxicity in cell culture.
Topics: Animals; Cells, Cultured; Drug Interactions; Glutamates; Glycine; Hippocampus; Kynurenic Acid; L-Lac | 1989 |
Amino acid levels in the guinea pig spinal gray matter after axotomy of primary sensory and descending tracts.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Axons; gamma-Aminobutyric Acid; Glutamates; Glutamic A | 1986 |
Changes in the content of glutamate and GABA in the cerebellar vermis and hemispheres of the Purkinje cell degeneration (pcd) mutant.
Topics: Alanine; Animals; Cerebellum; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Mice; Mic | 1988 |
[Effects of systemic administration of strychnine, L-allylglycine, bicuculline and picrotoxin on the transsynaptic neural destruction in the medullary dorsal horn following transection of the rat inferior alveolar nerve].
Topics: Allylglycine; Animals; Bicuculline; Glycine; Male; Mandibular Nerve; Medulla Oblongata; Nerve Degene | 1987 |
Strychnine and L-allylglycine but not bicuculline and picrotoxin induce transsynaptic degeneration following transection of the inferior alveolar nerve in adult rats.
Topics: Allylglycine; Animals; Bicuculline; Glycine; Mandibular Nerve; Medulla Oblongata; Nerve Degeneration | 1985 |
Effect of dorsal root section on amino acids of rat spinal cord.
Topics: Alanine; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Carbon Radioisotopes; Centrifugation, | 1974 |
Degenerative changes of neurocytes in the light of autoradiographic investigations.
Topics: Adenine; Amino Acids; Animals; Autoradiography; Brain; Carbon Isotopes; Cerebral Cortex; Disease Mod | 1971 |