glycine has been researched along with Muscle Spasticity in 20 studies
Muscle Spasticity: A form of muscle hypertonia associated with upper MOTOR NEURON DISEASE. Resistance to passive stretch of a spastic muscle results in minimal initial resistance (a free interval) followed by an incremental increase in muscle tone. Tone increases in proportion to the velocity of stretch. Spasticity is usually accompanied by HYPERREFLEXIA and variable degrees of MUSCLE WEAKNESS. (From Adams et al., Principles of Neurology, 6th ed, p54)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine whether the naturally occurring amino acid threonine, a potential precursor for glycine biosynthesis in the spinal cord, has an effect on spasticity in multiple sclerosis, 26 ambulatory patients were entered into a randomized crossover trial." | 9.07 | An antispasticity effect of threonine in multiple sclerosis. ( Doolittle, TH; Growdon, J; Hauser, SL; Lehrich, JR; Lopez-Bresnahan, M; Schoenfeld, D; Shahani, B; Shih, VE, 1992) |
| "To determine whether the naturally occurring amino acid threonine, a potential precursor for glycine biosynthesis in the spinal cord, has an effect on spasticity in multiple sclerosis, 26 ambulatory patients were entered into a randomized crossover trial." | 5.07 | An antispasticity effect of threonine in multiple sclerosis. ( Doolittle, TH; Growdon, J; Hauser, SL; Lehrich, JR; Lopez-Bresnahan, M; Schoenfeld, D; Shahani, B; Shih, VE, 1992) |
| "The term cerebral palsy is restricted to non-progressive disorders of motor function, already observed at an early age and due to cerebral lesions." | 2.37 | [Functional neurosurgery of cerebral palsy]. ( Alexandre, F; Angelini, L; Benezech, J; Broggi, G; Claverie, P; Deonna, T; Frerebeau, P; Lazorthes, Y; Siegfried, J; Verdie, JC, 1985) |
| "Spinal cord injury-induced spasticity, in the tail musculature, does not appear to involve either an increase in monosynaptic glutamatergic inputs from myelinated afferents or a decrease in glycinergic inputs to sacrocaudal motoneurons." | 1.34 | VGLUT1 and GLYT2 labeling of sacrocaudal motoneurons in the spinal cord injured spastic rat. ( Kitzman, P, 2007) |
| "Thus, in spastic, GlyRs are functionally normal but reduced in number, whereas in spasmodic, GlyR kinetics is faster." | 1.33 | Distinct physiological mechanisms underlie altered glycinergic synaptic transmission in the murine mutants spastic, spasmodic, and oscillator. ( Callister, RJ; Graham, BA; Margrie, TW; Sah, P; Schofield, PR, 2006) |
| "However, the overall structure of the spastic mutant retina was not disrupted because the distribution and intensity of both a presynaptic marker (synaptophysin) and a marker for the rod bipolar cell (protein kinase C) in the mutant retina were indistinguishable from those in normal retinas." | 1.29 | Glycine receptors in the retinas of normal and spastic mutant mice. ( Becker, CM; Grünert, U; Kirsch, J; Pinto, LH; Studholme, K; Yazulla, S, 1994) |
| "The role of glycine in spasticity and spinal shock was explored further in rabbits with ischemic spinal cord injuries that produced spastic paraparesis or flaccid paraplegia." | 1.29 | The role of glycine in spinal shock. ( Goodman, JC; Robertson, CS; Simpson, RK, 1996) |
| "Some of the clinical signs of spasticity improved in the animals injected with glycine compared to the saline-injected controls." | 1.26 | Effects of glycine administration on canine experimental spinal spasticity and the levels of glycine, glutamate, and aspartate in the lumbar spinal cord. ( Campbell, RL; Galvin, MR; Hall, PV; Jones, AR; Smith, JE, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (35.00) | 18.7374 |
| 1990's | 5 (25.00) | 18.2507 |
| 2000's | 4 (20.00) | 29.6817 |
| 2010's | 3 (15.00) | 24.3611 |
| 2020's | 1 (5.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tang, H | 1 |
| Peng, T | 1 |
| Yang, X | 1 |
| Liu, L | 1 |
| Xu, Y | 1 |
| Zhao, Y | 1 |
| Huang, S | 1 |
| Fu, C | 1 |
| Huang, Y | 1 |
| Zhou, H | 1 |
| Li, J | 1 |
| He, L | 1 |
| Wang, W | 1 |
| Niu, H | 1 |
| Xu, K | 1 |
| Kopach, O | 1 |
| Medvediev, V | 1 |
| Krotov, V | 1 |
| Borisyuk, A | 1 |
| Tsymbaliuk, V | 1 |
| Voitenko, N | 1 |
| Boulenguez, P | 2 |
| Liabeuf, S | 2 |
| Bos, R | 1 |
| Bras, H | 1 |
| Jean-Xavier, C | 1 |
| Brocard, C | 1 |
| Stil, A | 1 |
| Darbon, P | 1 |
| Cattaert, D | 1 |
| Delpire, E | 1 |
| Marsala, M | 1 |
| Vinay, L | 2 |
| CHAI, CK | 1 |
| ROBERTS, E | 1 |
| SIDMAN, RL | 1 |
| Zafonte, R | 1 |
| Lombard, L | 1 |
| Elovic, E | 1 |
| Graham, BA | 1 |
| Schofield, PR | 1 |
| Sah, P | 1 |
| Margrie, TW | 1 |
| Callister, RJ | 1 |
| Kitzman, P | 1 |
| Pinto, LH | 1 |
| Grünert, U | 1 |
| Studholme, K | 1 |
| Yazulla, S | 1 |
| Kirsch, J | 1 |
| Becker, CM | 1 |
| Simpson, RK | 2 |
| Gondo, M | 1 |
| Robertson, CS | 2 |
| Goodman, JC | 2 |
| Mertens, P | 1 |
| Ghaemmaghami, C | 1 |
| Bert, L | 1 |
| Perret-Liaudet, A | 1 |
| Sindou, M | 1 |
| Renaud, B | 1 |
| Hall, PV | 2 |
| Smith, JE | 2 |
| Campbell, RL | 2 |
| Felten, DL | 1 |
| Aprison, MH | 1 |
| Galvin, MR | 1 |
| Jones, AR | 1 |
| Hauser, SL | 1 |
| Doolittle, TH | 1 |
| Lopez-Bresnahan, M | 1 |
| Shahani, B | 1 |
| Schoenfeld, D | 1 |
| Shih, VE | 1 |
| Growdon, J | 1 |
| Lehrich, JR | 1 |
| Dietz, V | 1 |
| Davidoff, RA | 2 |
| Siegfried, J | 1 |
| Lazorthes, Y | 1 |
| Broggi, G | 1 |
| Claverie, P | 1 |
| Deonna, T | 1 |
| Frerebeau, P | 1 |
| Verdie, JC | 1 |
| Alexandre, F | 1 |
| Angelini, L | 1 |
| Benezech, J | 1 |
| Burke, D | 1 |
| Ionasescu, V | 1 |
| Stegink, L | 1 |
| Mueller, S | 1 |
| Weinstein, M | 1 |
4 reviews available for glycine and Muscle Spasticity
| Article | Year |
|---|---|
Antispasticity medications: uses and limitations of enteral therapy.
Topics: 4-Aminopyridine; Acetates; Adrenergic alpha-Agonists; Amines; Baclofen; Benzodiazepines; Cyclohexane | 2004 |
[Spasticity: therapy of increased reflexes or movement disorder?].
Topics: Baclofen; Clonidine; Combined Modality Therapy; Dantrolene; Diazepam; Glycine; Humans; Locomotion; M | 1990 |
Antispasticity drugs: mechanisms of action.
Topics: Adrenergic alpha-Antagonists; Animals; Anticonvulsants; Baclofen; Benzodiazepines; Central Nervous S | 1985 |
[Functional neurosurgery of cerebral palsy].
Topics: Adolescent; Adult; Animals; Baclofen; Benzodiazepines; Brain; Brain Diseases; Cerebellar Cortex; Cer | 1985 |
1 trial available for glycine and Muscle Spasticity
| Article | Year |
|---|---|
An antispasticity effect of threonine in multiple sclerosis.
Topics: Adult; Female; Glycine; Humans; Male; Multiple Sclerosis; Muscle Spasticity; Placebos; Threonine | 1992 |
15 other studies available for glycine and Muscle Spasticity
| Article | Year |
|---|---|
Plasma Metabolomic Changes in Children with Cerebral Palsy Exposed to Botulinum Neurotoxin.
Topics: Botulinum Toxins, Type A; Cerebral Palsy; Child; Cysteine; Glycine; Humans; Injections, Intramuscula | 2022 |
Opposite, bidirectional shifts in excitation and inhibition in specific types of dorsal horn interneurons are associated with spasticity and pain post-SCI.
Topics: Action Potentials; Animals; Chronic Pain; gamma-Aminobutyric Acid; Glycine; Interneurons; Male; Musc | 2017 |
Down-regulation of the potassium-chloride cotransporter KCC2 contributes to spasticity after spinal cord injury.
Topics: Animals; Blotting, Western; Brain-Derived Neurotrophic Factor; Carboxylic Acids; Chloride Channels; | 2010 |
[Reduced neuronal inhibition and spasticity following spinal cord injury].
Topics: Animals; Brain-Derived Neurotrophic Factor; Chlorides; gamma-Aminobutyric Acid; Glycine; H-Reflex; H | 2011 |
Influence of aminooxyacetic acid, a gamma-aminobutyrate transaminase inhibitor, on hereditary spastic defect in the mouse.
Topics: Aminobutyrates; Aminooxyacetic Acid; Animals; Glycine; Mice; Muscle Spasticity; Spasm; Transaminases | 1962 |
Distinct physiological mechanisms underlie altered glycinergic synaptic transmission in the murine mutants spastic, spasmodic, and oscillator.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Analysis of Variance; Animals; Biological Clocks; Brain Stem; | 2006 |
VGLUT1 and GLYT2 labeling of sacrocaudal motoneurons in the spinal cord injured spastic rat.
Topics: Animals; Behavior, Animal; Disease Progression; Female; Glutamic Acid; Glycine; Glycine Plasma Membr | 2007 |
Glycine receptors in the retinas of normal and spastic mutant mice.
Topics: Animals; Antibodies, Monoclonal; Carrier Proteins; Fluorescent Antibody Technique; Glycine; Membrane | 1994 |
The influence of glycine and related compounds on spinal cord injury-induced spasticity.
Topics: Animals; Electromyography; Glycine; H-Reflex; Male; Muscle Spasticity; Rabbits; Spinal Cord Injuries | 1995 |
The role of glycine in spinal shock.
Topics: Amino Acids; Animals; Electromyography; Evoked Potentials; Glycine; H-Reflex; Microdialysis; Motor C | 1996 |
Amino acids in spinal dorsal horn of patients during surgery for neuropathic pain or spasticity.
Topics: Amino Acids; Aspartic Acid; Chromatography, High Pressure Liquid; Extracellular Space; Feasibility S | 2000 |
Neurochemical correlates of spasticity.
Topics: Animals; Aspartic Acid; Dogs; Female; gamma-Aminobutyric Acid; Glutamates; Glycine; Muscle Spasticit | 1976 |
Effects of glycine administration on canine experimental spinal spasticity and the levels of glycine, glutamate, and aspartate in the lumbar spinal cord.
Topics: Animals; Aspartic Acid; Dogs; Female; Glutamates; Glycine; Muscle Hypotonia; Muscle Spasticity; Spin | 1979 |
Drug treatment of spasticity.
Topics: Aminobutyrates; Animals; Cats; Decerebrate State; Glycine; Humans; Motor Neurons; Muscle Spasticity; | 1970 |
Amino acid abnormality in Sjögren-Larsson syndrome.
Topics: Adolescent; Amino Acid Metabolism, Inborn Errors; Dental Enamel Hypoplasia; Epilepsy; Ethylamines; G | 1973 |