Page last updated: 2024-10-18

glycine and Movement Disorders

glycine has been researched along with Movement Disorders in 23 studies

Movement Disorders: Syndromes which feature DYSKINESIAS as a cardinal manifestation of the disease process. Included in this category are degenerative, hereditary, post-infectious, medication-induced, post-inflammatory, and post-traumatic conditions.

Research Excerpts

ExcerptRelevanceReference
"We performed a therapeutic trial with the glycine precursor, milacemide, on 10 patients with intractable movement disorders."9.07Therapeutic trial of milacemide in patients with myoclonus and other intractable movement disorders. ( Diaz-Olivo, R; Fahn, S; Gordon, MF; Hunt, AL, 1993)
"We performed a therapeutic trial with the glycine precursor, milacemide, on 10 patients with intractable movement disorders."5.07Therapeutic trial of milacemide in patients with myoclonus and other intractable movement disorders. ( Diaz-Olivo, R; Fahn, S; Gordon, MF; Hunt, AL, 1993)
"Glycine has important neurotransmitter functions at inhibitory and excitatory synapses in the vertebrate central nervous system."2.43Glycine transporters: essential regulators of neurotransmission. ( Armsen, W; Betz, H; Eulenburg, V; Gomeza, J, 2005)

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-19905 (21.74)18.7374
1990's3 (13.04)18.2507
2000's5 (21.74)29.6817
2010's9 (39.13)24.3611
2020's1 (4.35)2.80

Authors

AuthorsStudies
Balestrino, M1
Adriano, E1
Mirelman, A1
Saunders-Pullman, R1
Alcalay, RN1
Shustak, S1
Thaler, A1
Gurevich, T1
Raymond, D1
Mejia-Santana, H1
Orbe Reilly, M1
Ozelius, L1
Clark, L1
Gana-Weisz, M1
Bar-Shira, A1
Orr-Utreger, A1
Bressman, SB1
Marder, K1
Giladi, N1
Benoit, R1
Samir, M1
Boutin, J1
Samuel, A1
Brigitte, C1
Dominique, D1
Isabelle, RV1
El-Gharbawy, AH1
Goldstein, JL1
Millington, DS1
Vaisnins, AE1
Schlune, A2
Barshop, BA1
Schulze, A4
Koeberl, DD1
Young, SP1
Stockler-Ipsiroglu, S1
van Karnebeek, C1
Longo, N2
Korenke, GC1
Mercimek-Mahmutoglu, S2
Marquart, I1
Barshop, B1
Grolik, C2
Angle, B1
Araújo, HC2
Coskun, T1
Diogo, L1
Geraghty, M1
Haliloglu, G1
Konstantopoulou, V1
Leuzzi, V2
Levtova, A1
Mackenzie, J1
Maranda, B1
Mhanni, AA1
Mitchell, G1
Morris, A1
Newlove, T1
Renaud, D1
Scaglia, F1
Valayannopoulos, V1
van Spronsen, FJ1
Verbruggen, KT1
Yuskiv, N1
Nyhan, W1
Braissant, O2
Pasquali, M1
Schwarz, E1
Jensen, M1
Yuzyuk, T1
DeBiase, I1
Randall, H1
Pitt, JJ1
Tzanakos, N1
Nguyen, T1
Tran, C1
Levandovskiy, V1
Patel, V1
Cortez, MA1
Byrnes, KR1
Loane, DJ1
Stoica, BA1
Zhang, J1
Faden, AI1
Eulenburg, V1
Armsen, W1
Betz, H1
Gomeza, J1
Kay, DM1
Zabetian, CP1
Factor, SA1
Nutt, JG1
Samii, A1
Griffith, A1
Bird, TD1
Kramer, P1
Higgins, DS1
Payami, H1
Stoeckler-Ipsiroglu, S1
Adami, A1
Appleton, R1
Duran, M1
Ensenauer, R1
Fernandez-Alvarez, E1
Garcia, P1
Item, CB1
Marquardt, I1
Mühl, A1
Saelke-Kellermann, RA1
Salomons, GS1
Surtees, R1
van der Knaap, MS1
Vasconcelos, R1
Verhoeven, NM1
Vilarinho, L1
Wilichowski, E1
Jakobs, C1
Henry, H1
Gordon, MF1
Diaz-Olivo, R1
Hunt, AL1
Fahn, S1
Emery, ES1
Homans, AC1
Colletti, RB1
Crone, C1
Nielsen, J1
Petersen, N1
Tijssen, MA1
van Dijk, JG1
Becker, CM1
Larson, AA1
Davidoff, RA1
Graham, LT1
Shank, RP1
Werman, R1
Aprison, MH1
Kastin, AJ1
Barbeau, A1
van der Zee, SP1
Lommen, EJ1
Trijbels, JM1
Schretlen, ED1
Ghadimi, H1
Bhalla, CK1
Kirchenbaum, DM1

Reviews

3 reviews available for glycine and Movement Disorders

ArticleYear
Glycine transporters: essential regulators of neurotransmission.
    Trends in biochemical sciences, 2005, Volume: 30, Issue:6

    Topics: Amino Acid Transport Systems, Neutral; Animals; Glycine; Glycine Plasma Membrane Transport Proteins;

2005
AGAT, GAMT and SLC6A8 distribution in the central nervous system, in relation to creatine deficiency syndromes: a review.
    Journal of inherited metabolic disease, 2008, Volume: 31, Issue:2

    Topics: Amidinotransferases; Amino Acid Metabolism, Inborn Errors; Animals; Brain; Creatine; Developmental D

2008
Disorders of the inhibitory glycine receptor: the spastic mouse.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 1990, Volume: 4, Issue:10

    Topics: Animals; Disease Models, Animal; Glycine; Humans; Mice; Mice, Neurologic Mutants; Movement Disorders

1990

Trials

1 trial available for glycine and Movement Disorders

ArticleYear
Therapeutic trial of milacemide in patients with myoclonus and other intractable movement disorders.
    Movement disorders : official journal of the Movement Disorder Society, 1993, Volume: 8, Issue:4

    Topics: Acetamides; Administration, Oral; Adult; Aged; Basal Ganglia; Blood-Brain Barrier; Double-Blind Meth

1993

Other Studies

19 other studies available for glycine and Movement Disorders

ArticleYear
Presence of guanidinoacetate may compensate creatine absence and account for less statin-induced muscle damage in GAMT-deficient compared to AGAT-deficient mice.
    Amino acids, 2020, Volume: 52, Issue:4

    Topics: Amidinotransferases; Amino Acid Metabolism, Inborn Errors; Animals; Creatine; Developmental Disabili

2020
Application of the Movement Disorder Society prodromal criteria in healthy G2019S-LRRK2 carriers.
    Movement disorders : official journal of the Movement Disorder Society, 2018, Volume: 33, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Female; Glycine; Humans; Leucine-Rich Repeat Serine-Threonine Protei

2018
LC-MS/MS measurements of urinary guanidinoacetic acid and creatine: Method optimization by deleting derivatization step.
    Clinica chimica acta; international journal of clinical chemistry, 2019, Volume: 493

    Topics: Chromatography, High Pressure Liquid; Clinical Laboratory Techniques; Creatine; Glycine; Guanidinoac

2019
Elevation of guanidinoacetate in newborn dried blood spots and impact of early treatment in GAMT deficiency.
    Molecular genetics and metabolism, 2013, Volume: 109, Issue:2

    Topics: Case-Control Studies; Child, Preschool; Creatine; Dried Blood Spot Testing; Early Diagnosis; Female;

2013
Guanidinoacetate methyltransferase (GAMT) deficiency: outcomes in 48 individuals and recommendations for diagnosis, treatment and monitoring.
    Molecular genetics and metabolism, 2014, Volume: 111, Issue:1

    Topics: Adolescent; Adult; Arginine; Brain; Child; Child, Preschool; Combined Modality Therapy; Creatine; Fe

2014
GAMT deficiency: 20 years of a treatable inborn error of metabolism.
    Molecular genetics and metabolism, 2014, Volume: 111, Issue:1

    Topics: Arginine; Creatine; Female; Glycine; Guanidinoacetate N-Methyltransferase; Humans; Intellectual Disa

2014
Feasibility of newborn screening for guanidinoacetate methyltransferase (GAMT) deficiency.
    Journal of inherited metabolic disease, 2014, Volume: 37, Issue:2

    Topics: Brain; Creatine; Dried Blood Spot Testing; False Positive Reactions; Feasibility Studies; Glycine; G

2014
Newborn screening for guanidinoacetate methyl transferase deficiency.
    Molecular genetics and metabolism, 2014, Volume: 111, Issue:3

    Topics: Arginine; Creatine; Diet; Female; Glycine; Guanidinoacetate N-Methyltransferase; Humans; Intellectua

2014
Systemic availability of guanidinoacetate affects GABAA receptor function and seizure threshold in GAMT deficient mice.
    Amino acids, 2016, Volume: 48, Issue:8

    Topics: Animals; Electrocorticography; Glycine; Guanidinoacetate N-Methyltransferase; Language Development D

2016
Delayed mGluR5 activation limits neuroinflammation and neurodegeneration after traumatic brain injury.
    Journal of neuroinflammation, 2012, Feb-28, Volume: 9

    Topics: Animals; Brain Injuries; Calcium-Binding Proteins; Cognition Disorders; Diffusion Tensor Imaging; Di

2012
Parkinson's disease and LRRK2: frequency of a common mutation in U.S. movement disorder clinics.
    Movement disorders : official journal of the Movement Disorder Society, 2006, Volume: 21, Issue:4

    Topics: Adolescent; Adult; Age of Onset; Aged; Aged, 80 and over; DNA Mutational Analysis; Family Health; Fe

2006
GAMT deficiency: features, treatment, and outcome in an inborn error of creatine synthesis.
    Neurology, 2006, Aug-08, Volume: 67, Issue:3

    Topics: Adolescent; Adult; Child; Creatine; Epilepsy; Female; Glycine; Guanidinoacetate N-Methyltransferase;

2006
Vitamin B12 deficiency: a cause of abnormal movements in infants.
    Pediatrics, 1997, Volume: 99, Issue:2

    Topics: Glycine; Humans; Infant; Male; Movement Disorders; Vitamin B 12 Deficiency

1997
Patients with the major and minor form of hyperekplexia differ with regards to disynaptic reciprocal inhibition between ankle flexor and extensor muscles.
    Experimental brain research, 2001, Volume: 140, Issue:2

    Topics: Adult; Ankle Joint; Electromyography; Glycine; H-Reflex; Humans; Middle Aged; Movement Disorders; Mu

2001
Intrathecal GABA, glycine, taurine or beta-alanine elicits dyskinetic movements in mice.
    Pharmacology, biochemistry, and behavior, 1989, Volume: 32, Issue:2

    Topics: Alanine; Animals; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Glycine; Injections, In

1989
Changes in amino acid concentrations associated with loss of spinal interneurons.
    Journal of neurochemistry, 1967, Volume: 14, Issue:10

    Topics: Aminobutyrates; Animals; Aorta, Thoracic; Aortic Valve Stenosis; Aspartic Acid; Cats; Freezing; Glut

1967
Preliminary clinical studies with L-prolyl-L-leucyl-glycine amide in Parkinson's disease.
    Canadian Medical Association journal, 1972, Dec-09, Volume: 107, Issue:11

    Topics: Administration, Oral; Aged; Amides; Antiparkinson Agents; Dihydroxyphenylalanine; Female; Glycine; H

1972
The influence of adenine on the clinical features and purine metabolism in the Lesch-Nyhan syndrome.
    Acta paediatrica Scandinavica, 1970, Volume: 59, Issue:3

    Topics: Adenine; Allopurinol; Athetosis; Bone Marrow; Carbon Isotopes; Child; Child, Preschool; Chorea; Comp

1970
The significance of the deficiency state in Lesch-Nyhan disease.
    Acta paediatrica Scandinavica, 1970, Volume: 59, Issue:3

    Topics: Allopurinol; Amino Acids; Athetosis; Carbon Isotopes; Child, Preschool; Chorea; Compulsive Behavior;

1970