Page last updated: 2024-10-18

glycine and Morphine Abuse

glycine has been researched along with Morphine Abuse in 17 studies

Research Excerpts

ExcerptRelevanceReference
"Here, we report that following two exposures to morphine (20 mg/kg, sc) each followed by naloxone (1 mg/kg, sc) 24 h later, rats display nausea-like somatic reactions of lying flattened on belly, abdominal contractions and diarrhea, and display increased mouthing movements and loss of body weight."7.96Acute naloxone-precipitated morphine withdrawal elicits nausea-like somatic behaviors in rats in a manner suppressed by N-oleoylglycine. ( Ayoub, SM; DeVuono, MV; Di Marzo, V; Gene, A; Lichtman, AH; Limebeer, CL; Mechoulam, R; Parker, LA; Rock, EM; Smoum, R; Wills, KL, 2020)
" The contribution of various excitatory amino acid (EAA) receptors (NMDA, AMPA/kainate and metabotropic) in the brain to the development of morphine dependence was examined."7.69Effect of activity at metabotropic, as well as ionotropic (NMDA), glutamate receptors on morphine dependence. ( Coderre, TJ; Fundytus, ME, 1994)
"The ability of memantine (1-amino-3,5-dimethyl-adamantane) to block the expression and maintenance of morphine dependence was examined in mice."7.69The NMDA antagonist memantine blocks the expression and maintenance of morphine dependence. ( Popik, P; Skolnick, P, 1996)
"It was found that chronic and acute uses of both propargylglycine and hydroxylamine prevented the development of tolerance to morphine, whereas they had no effect on morphine dependence."4.02The Role of Hydrogen Sulfide in the Development of Tolerance and Dependence to Morphine in Mice. ( Cetin, Z; Dokmeci, D; Gunduz, O; Karadag, HC; Topuz, RD; Ulugol, A, 2021)
"Here, we report that following two exposures to morphine (20 mg/kg, sc) each followed by naloxone (1 mg/kg, sc) 24 h later, rats display nausea-like somatic reactions of lying flattened on belly, abdominal contractions and diarrhea, and display increased mouthing movements and loss of body weight."3.96Acute naloxone-precipitated morphine withdrawal elicits nausea-like somatic behaviors in rats in a manner suppressed by N-oleoylglycine. ( Ayoub, SM; DeVuono, MV; Di Marzo, V; Gene, A; Lichtman, AH; Limebeer, CL; Mechoulam, R; Parker, LA; Rock, EM; Smoum, R; Wills, KL, 2020)
" The contribution of various excitatory amino acid (EAA) receptors (NMDA, AMPA/kainate and metabotropic) in the brain to the development of morphine dependence was examined."3.69Effect of activity at metabotropic, as well as ionotropic (NMDA), glutamate receptors on morphine dependence. ( Coderre, TJ; Fundytus, ME, 1994)
"The ability of memantine (1-amino-3,5-dimethyl-adamantane) to block the expression and maintenance of morphine dependence was examined in mice."3.69The NMDA antagonist memantine blocks the expression and maintenance of morphine dependence. ( Popik, P; Skolnick, P, 1996)
"The effect of chronic administration of morphine to rats on the N-methyl-D-aspartate (NMDA) receptors labeled with [3H]MK-801, a non-competitive antagonist, was determined in brain regions and spinal cord."1.29Effect of morphine tolerance and abstinence on the binding of [3H]MK-801 to brain regions and spinal cord of the rat. ( Bhargava, HN; Gudehithlu, KP; Reddy, PL, 1994)
"Diazepam was ineffective in the analgesic test and it did not alter morphine analgesia, except when administered in a high dose which decreased and analgesic response."1.26Effects of glycine, beta-alanine and diazepam upon morphine-tolerant-dependent mice. ( Contreras, E; Tamayo, L, 1980)

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19906 (35.29)18.7374
1990's7 (41.18)18.2507
2000's1 (5.88)29.6817
2010's0 (0.00)24.3611
2020's3 (17.65)2.80

Authors

AuthorsStudies
Rock, EM2
Ayoub, SM2
Limebeer, CL2
Gene, A1
Wills, KL1
DeVuono, MV1
Smoum, R2
Di Marzo, V2
Lichtman, AH2
Mechoulam, R2
Parker, LA2
Farag, M1
Atwal, H1
Collins, SA1
Piscitelli, F1
Iannotti, FA1
Leri, F1
Cetin, Z1
Gunduz, O1
Topuz, RD1
Dokmeci, D1
Karadag, HC1
Ulugol, A1
Siggins, GR1
Martin, G1
Roberto, M1
Nie, Z1
Madamba, S1
De Lecea, L1
Contreras, E1
Tamayo, L1
Smith, JE1
Co, C1
Freeman, ME1
Sands, MP1
Lane, JD1
Contreras, PC1
Takemori, AE1
Bhargava, HN2
Reddy, PL2
Gudehithlu, KP2
Fundytus, ME2
Coderre, TJ2
Cappendijk, SL1
de Vries, R1
Dzoljic, MR1
Popik, P1
Skolnick, P1
Ritchie, J1
Dravolina, OA1
Medvedev, IO1
Bespalov, AY1
Davies, J1
Filipović, N1
Stern, P2
Fuks, Z1
Stern, M1

Reviews

1 review available for glycine and Morphine Abuse

ArticleYear
Glutamatergic transmission in opiate and alcohol dependence.
    Annals of the New York Academy of Sciences, 2003, Volume: 1003

    Topics: Alcoholism; Amygdala; Animals; Ethanol; Glutamates; Glycine; Humans; Morphine Dependence; Neurons; N

2003

Other Studies

16 other studies available for glycine and Morphine Abuse

ArticleYear
Acute naloxone-precipitated morphine withdrawal elicits nausea-like somatic behaviors in rats in a manner suppressed by N-oleoylglycine.
    Psychopharmacology, 2020, Volume: 237, Issue:2

    Topics: Animals; Female; Glycine; Male; Medically Unexplained Symptoms; Morphine; Morphine Dependence; Nalox

2020
Oleoyl alanine (HU595): a stable monomethylated oleoyl glycine interferes with acute naloxone precipitated morphine withdrawal in male rats.
    Psychopharmacology, 2020, Volume: 237, Issue:9

    Topics: Alanine; Analgesics, Opioid; Animals; Glycine; Male; Morphine; Morphine Dependence; Naloxone; Narcot

2020
The Role of Hydrogen Sulfide in the Development of Tolerance and Dependence to Morphine in Mice.
    Neuropsychobiology, 2021, Volume: 80, Issue:3

    Topics: Alkynes; Animals; Behavior, Animal; Disease Models, Animal; Drug Tolerance; Enzyme Inhibitors; Glyci

2021
Effects of glycine, beta-alanine and diazepam upon morphine-tolerant-dependent mice.
    The Journal of pharmacy and pharmacology, 1980, Volume: 32, Issue:5

    Topics: Alanine; Analgesia; Animals; beta-Alanine; Diazepam; Drug Interactions; Drug Tolerance; Female; Glyc

1980
Neurotransmitter turnover in rat striatum is correlated with morphine self-administration.
    Nature, 1980, Sep-11, Volume: 287, Issue:5778

    Topics: Animals; Aspartic Acid; Corpus Striatum; Dopamine; gamma-Aminobutyric Acid; Glutamates; Glycine; Hum

1980
Facilitation of morphine-induced tolerance and physical dependence by prolyl-leucyl-glycinamide.
    European journal of pharmacology, 1981, May-08, Volume: 71, Issue:2-3

    Topics: Analgesia; Animals; Body Temperature; Body Weight; Brain Chemistry; Drug Tolerance; Glycine; Humans;

1981
Down-regulation of N-methyl-D-aspartate (NMDA) receptors of brain regions and spinal cord of rats treated chronically with morphine.
    General pharmacology, 1995, Volume: 26, Issue:1

    Topics: Animals; Brain Chemistry; Dizocilpine Maleate; Down-Regulation; Glutamic Acid; Glycine; Male; Morphi

1995
Effect of activity at metabotropic, as well as ionotropic (NMDA), glutamate receptors on morphine dependence.
    British journal of pharmacology, 1994, Volume: 113, Issue:4

    Topics: Alanine; Animals; Anti-Anxiety Agents; Behavior, Animal; Benzoates; Benzodiazepines; Dizocilpine Mal

1994
Effect of morphine tolerance and abstinence on the binding of [3H]MK-801 to brain regions and spinal cord of the rat.
    Brain research, 1994, Mar-14, Volume: 639, Issue:2

    Topics: Animals; Brain; Dizocilpine Maleate; Down-Regulation; Drug Tolerance; Glutamates; Glutamic Acid; Gly

1994
Excitatory amino acid receptor antagonists and naloxone-precipitated withdrawal syndrome in morphine-dependent mice.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 1993, Volume: 3, Issue:2

    Topics: Animals; Behavior, Animal; Dizocilpine Maleate; Glycine; Kynurenic Acid; Male; Mice; Morphine Depend

1993
The NMDA antagonist memantine blocks the expression and maintenance of morphine dependence.
    Pharmacology, biochemistry, and behavior, 1996, Volume: 53, Issue:4

    Topics: Amino Acids; Animals; Brain Chemistry; Dose-Response Relationship, Drug; Electrophysiology; Excitato

1996
Attenuation of morphine withdrawal symptoms by subtype-selective metabotropic glutamate receptor antagonists.
    British journal of pharmacology, 1997, Volume: 120, Issue:6

    Topics: Amino Acids, Dicarboxylic; Aminobutyrates; Animals; Benzoates; Excitatory Amino Acid Antagonists; Gl

1997
Behavioural effects of glutamate receptor agonists in morphine-dependent rats.
    Behavioural pharmacology, 1999, Volume: 10, Issue:4

    Topics: Animals; Behavior, Animal; Brain Chemistry; Discrimination, Psychological; Dose-Response Relationshi

1999
Effects of morphine and naloxone on Renshaw cells and spinal interneurones in morphine dependent and non-dependent rats.
    Brain research, 1976, Aug-27, Volume: 113, Issue:2

    Topics: Acetylcholine; Animals; Dextrorphan; Evoked Potentials; gamma-Aminobutyric Acid; Glutamates; Glycine

1976
Effects of serine on morphine-dependent mice.
    Pharmacology, 1976, Volume: 14, Issue:3

    Topics: Animals; Brain; Drug Tolerance; Glycine; Humans; Male; Mice; Morphine Dependence; Nalorphine; Serine

1976
[Effect of glycine on chronic morphinism].
    Experientia, 1974, Dec-15, Volume: 30, Issue:12

    Topics: Aggression; Animals; Disease Models, Animal; Drug Synergism; Glycine; Humans; Mice; Morphine Depende

1974