glycine has been researched along with Lung Injury, Acute in 43 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sivelestat, a neutrophil elastase inhibitor, has been approved in Japan for the treatment of patients with acute lung injury (ALI) associated with systemic inflammatory response syndrome (SIRS)." | 9.15 | Reevaluation of the efficacy and safety of the neutrophil elastase inhibitor, Sivelestat, for the treatment of acute lung injury associated with systemic inflammatory response syndrome; a phase IV study. ( Aikawa, N; Endo, S; Hirasawa, H; Ikeda, T; Ishizaka, A; Kawasaki, Y; Shimazaki, S; Shinozaki, M; Sugimoto, H; Taenaka, N; Yamamoto, Y, 2011) |
| "This article summarizes the effects of sivelestat on acute lung injury/acute respiratory distress syndrome (ALI/ARDS) or ARDS with coagulopathy, both of which are frequently seen in patients with COVID-19." | 9.05 | Neutrophil elastase inhibitor (sivelestat) may be a promising therapeutic option for management of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19. ( Avan, R; Bagheri, M; Habtemariam, S; Khataminia, M; Rezai Ghaleno, H; Sadremomtaz, A; Safdari, M; Saghafi, F; Sahebnasagh, A; Talaei, Z, 2020) |
| "To investigate the effect of sivelestat sodium on the prognosis in patients with acute lung injury (ALI) and acute respiratory distress syndrome (ARDS)." | 8.91 | [Effect of sivelestat sodium on the prognosis of patients with acute lung injury and acute respiratory distress syndrome: a meta-analysis]. ( Shang, Y; Sun, Z; Xia, H; Yang, Y; Yao, S, 2015) |
| "Sivelestat is neutrophil elastase inhibitor, which is widely used in Japan for the treatment of acute lung injury." | 8.86 | Effect of neutrophil elastase inhibitor (sivelestat sodium) in the treatment of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS): a systematic review and meta-analysis. ( Doi, A; Gremillion, DH; Igarashi, W; Iwata, K; Oba, Y; Ohji, G; Oka, H; Shimada, T; Takimoto, K, 2010) |
| "To compare the protective effect of Xuebijing injection versus Sivelestat sodium on acute lung injury/acute respiratory distress syndrome (ALI/ARDS) rats." | 8.12 | [Comparative study of the protective effect of Xuebijing injection and Sivelestat sodium on acute lung injury/acute respiratory distress syndrome rats]. ( Dong, T; Tian, W, 2022) |
| "The efficacy of sivelestat, a neutrophil elastase inhibitor, for acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) remains controversial." | 7.85 | Efficacy of early sivelestat administration on acute lung injury and acute respiratory distress syndrome. ( Asakawa, T; Fujino, Y; Kido, T; Kubo, T; Matsuda, S; Mayumi, T; Mukae, H; Muramatsu, K; Otsubo, H; Yatera, K, 2017) |
| "A multicenter retrospective survey of patients poisoned by herbicides containing glyphosate salts in Japan was conducted to identify differences in symptoms and outcome of poisoning." | 7.83 | A multicenter retrospective survey of poisoning after ingestion of herbicides containing glyphosate potassium salt or other glyphosate salts in Japan. ( Kamijo, Y; Sakamoto, T; Takai, M, 2016) |
| "48 Sprague-Dawley (SD) rats were divided into 3 groups: normal control group, severe burns injury group and severe burns treated with sivelestat sodium hydrate group (SSI)." | 7.83 | Sivelestat sodium hydrate attenuates acute lung injury by decreasing systemic inflammation in a rat model of severe burns. ( Huang, P; Li, QG; Xiao, XG; Zu, HG, 2016) |
| " Sivelestat (SV), a neutrophil elastase inhibitor, is effective in reducing inflammation in acute lung injury." | 7.80 | Effects of sivelestat treatment on acute lung injury in paraquat-intoxicated rats. ( Choi, SY; Kim, H; Park, JS; Park, KH, 2014) |
| "Sivelestat, especially in a high dose, exerts a protective effect in acute lung injury after burn-blast combined injury through improving the index of blood gas analysis, ameliorating pulmonary edema, and lowering the production of pro-inflammatory mediators." | 7.80 | [Effects of sivelestat on acute lung injury in dogs with severe burn-blast combined injury]. ( Hou, Y; Hu, Q; Liu, L; Luo, H; Wang, Y; Yang, H, 2014) |
| " The effect of sivelestat on ALI patients was also examined based on whether they had sepsis and whether their initial serum procalcitonin level was ≥0." | 7.79 | Usefulness of a selective neutrophil elastase inhibitor, sivelestat, in acute lung injury patients with sepsis. ( Aibiki, M; Dote, K; Hamada, H; Higaki, J; Irifune, K; Ito, R; Kanematsu, T; Katayama, H; Miyoshi, S; Nakanishi, N; Okura, T; Suwaki, T, 2013) |
| "The present study aimed to investigate the combined effects of a neutrophil elastase inhibitor, sivelestat sodium, with a free radical scavenger, edaravone, on lipolysaccharide (LPS)-induced acute lung injury (ALI)." | 7.78 | Combined effects of a neutrophil elastase inhibitor (sivelestat sodium) and a free radical scavenger (edaravone) on lipopolysaccharide-induced acute lung injury in rats. ( Bao, R; Chen, H; Deng, X; Hou, J; Li, J; Liu, Y; Sun, L; Wang, J; Yang, T; Zhang, J; Zhu, X, 2012) |
| "Administration of sivelestat to patients with ALI/ARDS following surgery for abdominal sepsis resulted in early improvements of oxygenation and multiple organ dysfunction score, early ventilator weaning, and early discharge from the intensive care unit." | 7.78 | Clinical evaluation of sivelestat for acute lung injury/acute respiratory distress syndrome following surgery for abdominal sepsis. ( Mii, S; Nakazato, K; Sakamoto, A; Takeda, S; Tanaka, K; Tsuboko, Y; Uchida, E, 2012) |
| "Sivelestat, a neutrophil elastase inhibitor, has been used to treat acute lung injury (ALI) with varying levels of clinical success." | 7.76 | The impact of oxidative stress levels on the clinical effectiveness of sivelestat in treating acute lung injury: an electron spin resonance study. ( Goto, K; Hagiwara, S; Hidaka, S; Iwasaka, H; Koga, H; Matsumoto, S; Noguchi, T; Shingu, C; Yokoi, I, 2010) |
| " We investigated the patients' background, pneumonia severity score, the days from diagnosis of systemic inflammatory response syndrome (SIRS) to sivelestat administration, P/F ratio, SIRS score, and compared two groups: those who survived and those who died." | 7.74 | [Efficacy of sivelestat for acute lung injury due to severe bacterial pneumonia with systemic inflammatory response syndrome]. ( Izumikawa, K; Kakeya, H; Kohno, S; Mukae, H; Nakamura, S; Seki, M; Tashiro, T; Yamamoto, Y; Yanagihara, K, 2008) |
| "Sivelestat, a neutrophil elastase inhibitor, has been approved in Japan for the treatment of patients with acute lung injury (ALI) associated with systemic inflammatory response syndrome (SIRS)." | 5.15 | Reevaluation of the efficacy and safety of the neutrophil elastase inhibitor, Sivelestat, for the treatment of acute lung injury associated with systemic inflammatory response syndrome; a phase IV study. ( Aikawa, N; Endo, S; Hirasawa, H; Ikeda, T; Ishizaka, A; Kawasaki, Y; Shimazaki, S; Shinozaki, M; Sugimoto, H; Taenaka, N; Yamamoto, Y, 2011) |
| "This article summarizes the effects of sivelestat on acute lung injury/acute respiratory distress syndrome (ALI/ARDS) or ARDS with coagulopathy, both of which are frequently seen in patients with COVID-19." | 5.05 | Neutrophil elastase inhibitor (sivelestat) may be a promising therapeutic option for management of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19. ( Avan, R; Bagheri, M; Habtemariam, S; Khataminia, M; Rezai Ghaleno, H; Sadremomtaz, A; Safdari, M; Saghafi, F; Sahebnasagh, A; Talaei, Z, 2020) |
| "To investigate the effect of sivelestat sodium on the prognosis in patients with acute lung injury (ALI) and acute respiratory distress syndrome (ARDS)." | 4.91 | [Effect of sivelestat sodium on the prognosis of patients with acute lung injury and acute respiratory distress syndrome: a meta-analysis]. ( Shang, Y; Sun, Z; Xia, H; Yang, Y; Yao, S, 2015) |
| "Sivelestat is neutrophil elastase inhibitor, which is widely used in Japan for the treatment of acute lung injury." | 4.86 | Effect of neutrophil elastase inhibitor (sivelestat sodium) in the treatment of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS): a systematic review and meta-analysis. ( Doi, A; Gremillion, DH; Igarashi, W; Iwata, K; Oba, Y; Ohji, G; Oka, H; Shimada, T; Takimoto, K, 2010) |
| "To compare the protective effect of Xuebijing injection versus Sivelestat sodium on acute lung injury/acute respiratory distress syndrome (ALI/ARDS) rats." | 4.12 | [Comparative study of the protective effect of Xuebijing injection and Sivelestat sodium on acute lung injury/acute respiratory distress syndrome rats]. ( Dong, T; Tian, W, 2022) |
| "The efficacy of sivelestat, a neutrophil elastase inhibitor, for acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) remains controversial." | 3.85 | Efficacy of early sivelestat administration on acute lung injury and acute respiratory distress syndrome. ( Asakawa, T; Fujino, Y; Kido, T; Kubo, T; Matsuda, S; Mayumi, T; Mukae, H; Muramatsu, K; Otsubo, H; Yatera, K, 2017) |
| "Sivelestat significantly attenuated LPS-induced ALI during recovery from neutropenia, and this effect was associated with MerTK induction." | 3.85 | Inhibition of neutrophil elastase contributes to attenuation of lipopolysaccharide-induced acute lung injury during neutropenia recovery in mice. ( Kim, IK; Kim, JW; Lee, DG; Lee, HY; Lee, JM; Lee, SH; Rhee, CK; Yeo, CD, 2017) |
| "48 Sprague-Dawley (SD) rats were divided into 3 groups: normal control group, severe burns injury group and severe burns treated with sivelestat sodium hydrate group (SSI)." | 3.83 | Sivelestat sodium hydrate attenuates acute lung injury by decreasing systemic inflammation in a rat model of severe burns. ( Huang, P; Li, QG; Xiao, XG; Zu, HG, 2016) |
| "A multicenter retrospective survey of patients poisoned by herbicides containing glyphosate salts in Japan was conducted to identify differences in symptoms and outcome of poisoning." | 3.83 | A multicenter retrospective survey of poisoning after ingestion of herbicides containing glyphosate potassium salt or other glyphosate salts in Japan. ( Kamijo, Y; Sakamoto, T; Takai, M, 2016) |
| "Sivelestat, especially in a high dose, exerts a protective effect in acute lung injury after burn-blast combined injury through improving the index of blood gas analysis, ameliorating pulmonary edema, and lowering the production of pro-inflammatory mediators." | 3.80 | [Effects of sivelestat on acute lung injury in dogs with severe burn-blast combined injury]. ( Hou, Y; Hu, Q; Liu, L; Luo, H; Wang, Y; Yang, H, 2014) |
| " Sivelestat (SV), a neutrophil elastase inhibitor, is effective in reducing inflammation in acute lung injury." | 3.80 | Effects of sivelestat treatment on acute lung injury in paraquat-intoxicated rats. ( Choi, SY; Kim, H; Park, JS; Park, KH, 2014) |
| " The effect of sivelestat on ALI patients was also examined based on whether they had sepsis and whether their initial serum procalcitonin level was ≥0." | 3.79 | Usefulness of a selective neutrophil elastase inhibitor, sivelestat, in acute lung injury patients with sepsis. ( Aibiki, M; Dote, K; Hamada, H; Higaki, J; Irifune, K; Ito, R; Kanematsu, T; Katayama, H; Miyoshi, S; Nakanishi, N; Okura, T; Suwaki, T, 2013) |
| "Sivelestat, a selective inhibitor of neutrophil elastase, has been reported to reduce acute lung injury associated with systemic inflammatory response syndrome." | 3.79 | Preventive effect of sivelestat on postoperative respiratory disorders after thoracic esophagectomy. ( Baba, H; Baba, Y; Hirashima, K; Iwatsuki, M; Karashima, R; Kinoshita, K; Kurashige, J; Nagai, Y; Watanabe, M, 2013) |
| "The present study aimed to investigate the combined effects of a neutrophil elastase inhibitor, sivelestat sodium, with a free radical scavenger, edaravone, on lipolysaccharide (LPS)-induced acute lung injury (ALI)." | 3.78 | Combined effects of a neutrophil elastase inhibitor (sivelestat sodium) and a free radical scavenger (edaravone) on lipopolysaccharide-induced acute lung injury in rats. ( Bao, R; Chen, H; Deng, X; Hou, J; Li, J; Liu, Y; Sun, L; Wang, J; Yang, T; Zhang, J; Zhu, X, 2012) |
| "Administration of sivelestat to patients with ALI/ARDS following surgery for abdominal sepsis resulted in early improvements of oxygenation and multiple organ dysfunction score, early ventilator weaning, and early discharge from the intensive care unit." | 3.78 | Clinical evaluation of sivelestat for acute lung injury/acute respiratory distress syndrome following surgery for abdominal sepsis. ( Mii, S; Nakazato, K; Sakamoto, A; Takeda, S; Tanaka, K; Tsuboko, Y; Uchida, E, 2012) |
| "Sivelestat, a neutrophil elastase inhibitor, has been used to treat acute lung injury (ALI) with varying levels of clinical success." | 3.76 | The impact of oxidative stress levels on the clinical effectiveness of sivelestat in treating acute lung injury: an electron spin resonance study. ( Goto, K; Hagiwara, S; Hidaka, S; Iwasaka, H; Koga, H; Matsumoto, S; Noguchi, T; Shingu, C; Yokoi, I, 2010) |
| " The present study was designed to examine whether inhibition of NE activity by sivelestat, a specific NE inhibitor with low cellular permeability, is beneficial for acute lung injury induced by Streptococcus pneumoniae in hamsters." | 3.74 | Inhibition of neutrophil elastase reduces lung injury and bacterial count in hamsters. ( Hagio, T; Hasegawa, N; Hashimoto, S; Ishizaka, A; Kawabata, K; Kishikawa, K; Tasaka, S, 2008) |
| " We investigated the patients' background, pneumonia severity score, the days from diagnosis of systemic inflammatory response syndrome (SIRS) to sivelestat administration, P/F ratio, SIRS score, and compared two groups: those who survived and those who died." | 3.74 | [Efficacy of sivelestat for acute lung injury due to severe bacterial pneumonia with systemic inflammatory response syndrome]. ( Izumikawa, K; Kakeya, H; Kohno, S; Mukae, H; Nakamura, S; Seki, M; Tashiro, T; Yamamoto, Y; Yanagihara, K, 2008) |
| "Twenty-two patients with thoracic esophageal cancer underwent video-assisted thoracoscopic esophagectomy with extended lymph node dissection in our institution between April 2007 and November 2008." | 2.75 | Prospective randomized controlled study on the effects of perioperative administration of a neutrophil elastase inhibitor to patients undergoing video-assisted thoracoscopic surgery for thoracic esophageal cancer. ( Fujimura, T; Funaki, H; Fushida, S; Inaba, H; Kawahara, Y; Kayahara, M; Nakagawara, H; Ninomiya, I; Oyama, K; Tajima, H; Takamura, H, 2010) |
| "Treatment with sivelestat significantly improved survival rate with P = 0." | 1.39 | Sivelestat improves outcome of crush injury by inhibiting high-mobility group box 1 in rats. ( Abe, C; Binh, NH; Cuong, NT; Hara, A; Morita, H; Ogura, S, 2013) |
| " Finally, AZD9668 prevented airspace enlargement and small airway wall remodeling in guinea pigs in response to chronic tobacco smoke exposure whether dosed therapeutically or prophylactically." | 1.37 | AZD9668: pharmacological characterization of a novel oral inhibitor of neutrophil elastase. ( Churg, A; Ekholm, K; Falk-Håkansson, H; Gränse, M; Jungar, C; Kozma, V; Lal, H; Lindahl, M; Ottosson, T; Sanfridson, A; Stevens, T; Wright, JL, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (4.65) | 29.6817 |
| 2010's | 37 (86.05) | 24.3611 |
| 2020's | 4 (9.30) | 2.80 |
| Authors | Studies |
|---|---|
| Tian, W | 1 |
| Dong, T | 1 |
| Zhang, Y | 2 |
| Ma, X | 1 |
| Jiang, D | 1 |
| Chen, J | 1 |
| Jia, H | 1 |
| Wu, Z | 1 |
| Kim, IH | 1 |
| Yang, Y | 2 |
| Han, F | 1 |
| Wu, G | 1 |
| Han, S | 1 |
| Li, Z | 1 |
| Jia, Y | 1 |
| Bai, L | 1 |
| Li, X | 1 |
| Wang, K | 1 |
| Yang, F | 1 |
| Zhang, J | 2 |
| Wang, X | 1 |
| Guan, H | 1 |
| Linlin, S | 1 |
| Han, J | 1 |
| Hu, D | 1 |
| Sahebnasagh, A | 1 |
| Saghafi, F | 1 |
| Safdari, M | 1 |
| Khataminia, M | 1 |
| Sadremomtaz, A | 1 |
| Talaei, Z | 1 |
| Rezai Ghaleno, H | 1 |
| Bagheri, M | 1 |
| Habtemariam, S | 1 |
| Avan, R | 1 |
| Yu, D | 1 |
| Fang, X | 1 |
| Xu, Y | 1 |
| Xiao, H | 1 |
| Huang, T | 1 |
| Ge, Y | 1 |
| Li, Y | 1 |
| Zong, L | 1 |
| Gao, J | 1 |
| Nagai, Y | 1 |
| Watanabe, M | 1 |
| Baba, Y | 1 |
| Iwatsuki, M | 1 |
| Hirashima, K | 1 |
| Karashima, R | 1 |
| Kurashige, J | 1 |
| Kinoshita, K | 1 |
| Baba, H | 1 |
| Aikawa, N | 2 |
| Lee, SK | 1 |
| Son, BS | 1 |
| Hwang, JJ | 1 |
| Kim, KD | 1 |
| Kim, DH | 1 |
| Miyoshi, S | 1 |
| Hamada, H | 1 |
| Ito, R | 1 |
| Katayama, H | 1 |
| Irifune, K | 1 |
| Suwaki, T | 1 |
| Nakanishi, N | 1 |
| Kanematsu, T | 1 |
| Dote, K | 1 |
| Aibiki, M | 1 |
| Okura, T | 1 |
| Higaki, J | 1 |
| Eguchi, T | 1 |
| Yoshida, K | 1 |
| Kondo, R | 1 |
| Hamanaka, K | 1 |
| Shiina, T | 1 |
| Komatsu, Y | 1 |
| Yamamoto, H | 1 |
| Kubo, K | 2 |
| Hasegawa, J | 1 |
| Koizumi, T | 2 |
| Park, JS | 1 |
| Park, KH | 1 |
| Kim, H | 1 |
| Choi, SY | 1 |
| Yuan, Q | 1 |
| Jiang, YW | 1 |
| Fang, QH | 1 |
| Wang, Y | 1 |
| Yang, H | 1 |
| Hu, Q | 1 |
| Hou, Y | 1 |
| Luo, H | 1 |
| Liu, L | 1 |
| Wang, ZQ | 1 |
| Chen, LQ | 1 |
| Yuan, Y | 1 |
| Wang, WP | 1 |
| Niu, ZX | 1 |
| Yang, YS | 1 |
| Cai, J | 1 |
| Kamijo, Y | 1 |
| Takai, M | 1 |
| Sakamoto, T | 1 |
| Tang, B | 1 |
| Ma, L | 2 |
| Yao, X | 1 |
| Tan, G | 1 |
| Han, P | 1 |
| Yu, T | 1 |
| Liu, B | 1 |
| Sun, X | 1 |
| Xiao, XG | 1 |
| Zu, HG | 1 |
| Li, QG | 1 |
| Huang, P | 1 |
| Xia, H | 1 |
| Sun, Z | 1 |
| Shang, Y | 1 |
| Yao, S | 1 |
| Guo, Y | 1 |
| Zhang, F | 1 |
| Sun, R | 1 |
| Li, T | 1 |
| Kido, T | 1 |
| Muramatsu, K | 1 |
| Yatera, K | 1 |
| Asakawa, T | 1 |
| Otsubo, H | 1 |
| Kubo, T | 1 |
| Fujino, Y | 1 |
| Matsuda, S | 1 |
| Mayumi, T | 1 |
| Mukae, H | 2 |
| Lee, JM | 1 |
| Yeo, CD | 1 |
| Lee, HY | 1 |
| Rhee, CK | 1 |
| Kim, IK | 1 |
| Lee, DG | 1 |
| Lee, SH | 1 |
| Kim, JW | 1 |
| Hagio, T | 1 |
| Kishikawa, K | 1 |
| Kawabata, K | 1 |
| Tasaka, S | 1 |
| Hashimoto, S | 1 |
| Hasegawa, N | 1 |
| Ishizaka, A | 2 |
| Nakamura, S | 1 |
| Yanagihara, K | 1 |
| Izumikawa, K | 1 |
| Seki, M | 1 |
| Kakeya, H | 1 |
| Yamamoto, Y | 2 |
| Tashiro, T | 1 |
| Kohno, S | 1 |
| Kawahara, Y | 1 |
| Ninomiya, I | 1 |
| Fujimura, T | 1 |
| Funaki, H | 1 |
| Nakagawara, H | 1 |
| Takamura, H | 1 |
| Oyama, K | 1 |
| Tajima, H | 1 |
| Fushida, S | 1 |
| Inaba, H | 1 |
| Kayahara, M | 1 |
| Matsumoto, S | 1 |
| Shingu, C | 1 |
| Koga, H | 1 |
| Hidaka, S | 1 |
| Goto, K | 1 |
| Hagiwara, S | 1 |
| Iwasaka, H | 1 |
| Noguchi, T | 1 |
| Yokoi, I | 1 |
| Yokoyama, T | 1 |
| Tsushima, K | 1 |
| Ushiki, A | 1 |
| Kobayashi, N | 1 |
| Urushihata, K | 1 |
| Fujii, M | 1 |
| Miyagi, Y | 1 |
| Bessho, R | 1 |
| Nitta, T | 1 |
| Ochi, M | 1 |
| Shimizu, K | 1 |
| Kaido, T | 1 |
| Uemoto, S | 1 |
| Ishii, T | 1 |
| Doi, K | 1 |
| Okamoto, K | 1 |
| Imamura, M | 1 |
| Dohi, M | 1 |
| Yamamoto, K | 1 |
| Fujita, T | 1 |
| Noiri, E | 1 |
| Shibata, S | 1 |
| Takahashi, G | 1 |
| Shioya, N | 1 |
| Inada, K | 1 |
| Endo, S | 2 |
| Iwata, K | 2 |
| Doi, A | 1 |
| Ohji, G | 1 |
| Oka, H | 1 |
| Oba, Y | 1 |
| Takimoto, K | 1 |
| Igarashi, W | 1 |
| Gremillion, DH | 1 |
| Shimada, T | 1 |
| Hirasawa, H | 1 |
| Shimazaki, S | 1 |
| Sugimoto, H | 1 |
| Shinozaki, M | 1 |
| Taenaka, N | 1 |
| Ikeda, T | 1 |
| Kawasaki, Y | 1 |
| Yamaguchi, K | 1 |
| Sugasawa, Y | 1 |
| Takeuchi, K | 1 |
| Kugimiya, T | 1 |
| Kumakura, S | 1 |
| Iwanuma, Y | 1 |
| Kajiyama, Y | 1 |
| Tsurumaru, M | 1 |
| Nagaoka, I | 1 |
| Inada, E | 1 |
| Hayashida, K | 1 |
| Fujishima, S | 1 |
| Sasao, K | 1 |
| Orita, T | 1 |
| Toyoda, Y | 1 |
| Kitano, M | 1 |
| Hori, S | 1 |
| Stevens, T | 1 |
| Ekholm, K | 1 |
| Gränse, M | 1 |
| Lindahl, M | 1 |
| Kozma, V | 1 |
| Jungar, C | 1 |
| Ottosson, T | 1 |
| Falk-Håkansson, H | 1 |
| Churg, A | 1 |
| Wright, JL | 1 |
| Lal, H | 1 |
| Sanfridson, A | 1 |
| Fujino, N | 1 |
| Kubo, H | 1 |
| Suzuki, T | 3 |
| He, M | 1 |
| Yamada, M | 1 |
| Takahashi, T | 1 |
| Ota, C | 1 |
| Yamaya, M | 1 |
| Nishiyama, J | 1 |
| Matsuda, M | 1 |
| Ando, S | 1 |
| Hirasawa, M | 1 |
| Makuuchi, H | 1 |
| Tao, W | 1 |
| Miao, QB | 1 |
| Zhu, YB | 1 |
| Shu, YS | 1 |
| Lin, CC | 1 |
| Liu, PH | 1 |
| Kao, SJ | 1 |
| Chen, HI | 1 |
| Yang, T | 1 |
| Sun, L | 1 |
| Zhu, X | 1 |
| Li, J | 1 |
| Wang, J | 1 |
| Chen, H | 1 |
| Bao, R | 1 |
| Deng, X | 1 |
| Hou, J | 1 |
| Liu, Y | 1 |
| Tsuboko, Y | 1 |
| Takeda, S | 1 |
| Mii, S | 1 |
| Nakazato, K | 1 |
| Tanaka, K | 1 |
| Uchida, E | 1 |
| Sakamoto, A | 1 |
| Cuong, NT | 1 |
| Abe, C | 1 |
| Binh, NH | 1 |
| Hara, A | 1 |
| Morita, H | 1 |
| Ogura, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Pilot Study of Perioperative Application of Sivelestat Sodium in Acute Type A Aortic Dissection Patients With Preoperative Moderate to Severe Hypoxemia to Shorten the Duration of Postoperative Invasive Mechanical Ventilation[NCT05874700] | 30 participants (Anticipated) | Interventional | 2023-05-31 | Not yet recruiting | |||
| Clinical Study of Neutrophil Elastase Inhibitor in Treatment of Acute Respiratory Distress Syndrome Patients With Mechanical Ventilation Caused by Sepsis[NCT05672472] | 100 participants (Anticipated) | Interventional | 2023-01-10 | Not yet recruiting | |||
| Pirfenidone to Prevent Fibrosis in ARDS. A Randomized Controlled Trial - PIONEER[NCT05075161] | Phase 3 | 130 participants (Anticipated) | Interventional | 2022-06-01 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for glycine and Lung Injury, Acute
| Article | Year |
|---|---|
Neutrophil elastase inhibitor (sivelestat) may be a promising therapeutic option for management of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19.
Topics: Acute Lung Injury; COVID-19; COVID-19 Drug Treatment; Disseminated Intravascular Coagulation; Glycin | 2020 |
Effects of neutrophil elastase inhibitor in patients undergoing esophagectomy: a systematic review and meta-analysis.
Topics: Acute Lung Injury; Aged; Esophagectomy; Female; Glycine; Humans; Leukocyte Elastase; Male; Middle Ag | 2015 |
[Effect of sivelestat sodium on the prognosis of patients with acute lung injury and acute respiratory distress syndrome: a meta-analysis].
Topics: Acute Lung Injury; China; Glycine; Humans; Intensive Care Units; Length of Stay; Prognosis; Randomiz | 2015 |
Effect of neutrophil elastase inhibitor (sivelestat sodium) in the treatment of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS): a systematic review and meta-analysis.
Topics: Acute Lung Injury; Glycine; Humans; Proteinase Inhibitory Proteins, Secretory; Randomized Controlled | 2010 |
6 trials available for glycine and Lung Injury, Acute
| Article | Year |
|---|---|
Sivelestat prevents cytoskeletal rearrangements in neutrophils resulting from lung re-expansion following one-lung ventilation during thoracic surgery.
Topics: Actin Cytoskeleton; Actins; Acute Lung Injury; Aged; Aged, 80 and over; Female; Glycine; Humans; Int | 2013 |
Prospective randomized controlled study on the effects of perioperative administration of a neutrophil elastase inhibitor to patients undergoing video-assisted thoracoscopic surgery for thoracic esophageal cancer.
Topics: Acute Lung Injury; Aged; Double-Blind Method; Esophageal Neoplasms; Esophagectomy; Female; Glycine; | 2010 |
Effect of a neutrophil elastase inhibitor on acute lung injury after cardiopulmonary bypass.
Topics: Acute Lung Injury; Aged; Anti-Inflammatory Agents; Aortic Valve; Bronchoalveolar Lavage; Bronchoalve | 2010 |
Effects of neutrophil elastase inhibitor on progression of acute lung injury after liver transplantation.
Topics: Acute Lung Injury; Glycine; Humans; Infusions, Intravenous; Leukocyte Elastase; Liver Transplantatio | 2010 |
Reevaluation of the efficacy and safety of the neutrophil elastase inhibitor, Sivelestat, for the treatment of acute lung injury associated with systemic inflammatory response syndrome; a phase IV study.
Topics: Acute Lung Injury; Aged; Aged, 80 and over; Female; Glycine; Humans; Infusions, Intravenous; Male; M | 2011 |
Effects of sivelestat on bronchial inflammatory responses after esophagectomy.
Topics: Acute Lung Injury; Aged; Bronchitis; Esophagectomy; Female; Glycine; Humans; Interleukin-6; Interleu | 2011 |
33 other studies available for glycine and Lung Injury, Acute
| Article | Year |
|---|---|
[Comparative study of the protective effect of Xuebijing injection and Sivelestat sodium on acute lung injury/acute respiratory distress syndrome rats].
Topics: Acute Lung Injury; Animals; Drugs, Chinese Herbal; Glycine; Interleukin-6; Lipopolysaccharides; Lung | 2022 |
Glycine Attenuates Lipopolysaccharide-Induced Acute Lung Injury by Regulating NLRP3 Inflammasome and NRF2 Signaling.
Topics: Acute Lung Injury; Animals; Autophagy; Cytokines; Down-Regulation; Glycine; HSP40 Heat-Shock Protein | 2020 |
Hypoxia-inducible factor prolyl-hydroxylase inhibitor roxadustat (FG-4592) alleviates sepsis-induced acute lung injury.
Topics: Acute Lung Injury; Animals; Cells, Cultured; Disease Models, Animal; Glycine; Hypoxia-Inducible Fact | 2020 |
Rev-erbα can regulate the NF-κB/NALP3 pathway to modulate lipopolysaccharide-induced acute lung injury and inflammation.
Topics: Acute Lung Injury; Animals; Glycine; Interleukin-1beta; Isoquinolines; Lipopolysaccharides; Lung; Ma | 2019 |
Preventive effect of sivelestat on postoperative respiratory disorders after thoracic esophagectomy.
Topics: Acute Lung Injury; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents; Drug Administration Sch | 2013 |
The propensity score analysis on the efficacy of Sivelestat - author's reply.
Topics: Acute Lung Injury; Female; Glycine; Humans; Male; Serine Proteinase Inhibitors; Sulfonamides; System | 2013 |
The use of neutrophil elastase inhibitor in the treatment of acute lung injury after pneumonectomy.
Topics: Acute Lung Injury; Adult; Aged; Combined Modality Therapy; Drug Administration Schedule; Glycine; Hu | 2013 |
Usefulness of a selective neutrophil elastase inhibitor, sivelestat, in acute lung injury patients with sepsis.
Topics: Acute Lung Injury; Aged; Calcitonin; Calcitonin Gene-Related Peptide; Female; Glycine; Humans; Male; | 2013 |
Usefulness of a selective neutrophil elastase inhibitor, sivelestat, in acute lung injury patients with sepsis.
Topics: Acute Lung Injury; Aged; Calcitonin; Calcitonin Gene-Related Peptide; Female; Glycine; Humans; Male; | 2013 |
Usefulness of a selective neutrophil elastase inhibitor, sivelestat, in acute lung injury patients with sepsis.
Topics: Acute Lung Injury; Aged; Calcitonin; Calcitonin Gene-Related Peptide; Female; Glycine; Humans; Male; | 2013 |
Usefulness of a selective neutrophil elastase inhibitor, sivelestat, in acute lung injury patients with sepsis.
Topics: Acute Lung Injury; Aged; Calcitonin; Calcitonin Gene-Related Peptide; Female; Glycine; Humans; Male; | 2013 |
Effects of sivelestat treatment on acute lung injury in paraquat-intoxicated rats.
Topics: Acute Lung Injury; Animals; Glycine; Histological Techniques; Injections, Intraperitoneal; Interleuk | 2014 |
Improving effect of Sivelestat on lipopolysaccharide-induced lung injury in rats.
Topics: Acute Lung Injury; Animals; Endothelial Cells; Glycine; Intercellular Adhesion Molecule-1; Leukocyte | 2014 |
[Effects of sivelestat on acute lung injury in dogs with severe burn-blast combined injury].
Topics: Acute Lung Injury; Animals; Blood Gas Analysis; Burns; Capillary Permeability; Dogs; Extravascular L | 2014 |
A multicenter retrospective survey of poisoning after ingestion of herbicides containing glyphosate potassium salt or other glyphosate salts in Japan.
Topics: Acute Lung Injury; Adult; Aged; Aged, 80 and over; Chemical and Drug Induced Liver Injury; Dose-Resp | 2016 |
Hydrogen sulfide ameliorates acute lung injury induced by infrarenal aortic cross-clamping by inhibiting inflammation and angiopoietin 2 release.
Topics: Acute Lung Injury; Alkynes; Angiopoietin-2; Animals; Anti-Inflammatory Agents; Aorta, Abdominal; Con | 2017 |
Sivelestat sodium hydrate attenuates acute lung injury by decreasing systemic inflammation in a rat model of severe burns.
Topics: Acute Lung Injury; Animals; Blood Gas Analysis; Burns; Disease Models, Animal; Glycine; Inflammation | 2016 |
Neutrophil elastase ameliorates matrix metalloproteinase-9 to promote lipopolysaccharide-induced acute lung injury in mice 1.
Topics: Acute Lung Injury; Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Glycine; Inflammat | 2016 |
Efficacy of early sivelestat administration on acute lung injury and acute respiratory distress syndrome.
Topics: Acute Lung Injury; Aged; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Fol | 2017 |
Inhibition of neutrophil elastase contributes to attenuation of lipopolysaccharide-induced acute lung injury during neutropenia recovery in mice.
Topics: Acute Lung Injury; Animals; Bronchoalveolar Lavage Fluid; Female; Glycine; Intercellular Adhesion Mo | 2017 |
Inhibition of neutrophil elastase reduces lung injury and bacterial count in hamsters.
Topics: Acute Lung Injury; Animals; Bronchoalveolar Lavage Fluid; Colony Count, Microbial; Cricetinae; Disea | 2008 |
[Efficacy of sivelestat for acute lung injury due to severe bacterial pneumonia with systemic inflammatory response syndrome].
Topics: Acute Lung Injury; Aged; Aged, 80 and over; Female; Glycine; Humans; Leukocyte Elastase; Male; Pneum | 2008 |
The impact of oxidative stress levels on the clinical effectiveness of sivelestat in treating acute lung injury: an electron spin resonance study.
Topics: Acute Lung Injury; Adult; Aged; Analysis of Variance; Chromatography, High Pressure Liquid; Dehydroa | 2010 |
Acute lung injury with alveolar hemorrhage due to a novel swine-origin influenza A (H1N1) virus.
Topics: Acute Lung Injury; Adult; Antiviral Agents; Female; Glycine; Hemorrhage; Humans; Influenza A Virus, | 2010 |
Neutrophil elastase contributes to acute lung injury induced by bilateral nephrectomy.
Topics: Acute Lung Injury; Animals; Blotting, Western; Chemokines; Glycine; Interleukin-6; Leukocyte Elastas | 2010 |
Suppressive effects of sivelestat on interleukin 8 and TNF-α production from LPS-stimulated granulocytes in whole blood culture.
Topics: Acute Lung Injury; Flow Cytometry; Glycine; Granulocytes; Humans; In Vitro Techniques; Interleukin-8 | 2010 |
Early administration of sivelestat, the neutrophil elastase inhibitor, in adults for acute lung injury following gastric aspiration.
Topics: Acute Lung Injury; Aged; Aged, 80 and over; Female; Glycine; Humans; Laryngopharyngeal Reflux; Male; | 2011 |
AZD9668: pharmacological characterization of a novel oral inhibitor of neutrophil elastase.
Topics: Acute Lung Injury; Animals; Bronchoalveolar Lavage Fluid; Dogs; Dose-Response Relationship, Drug; Em | 2011 |
Administration of a specific inhibitor of neutrophil elastase attenuates pulmonary fibrosis after acute lung injury in mice.
Topics: Acute Lung Injury; Animals; Bronchoalveolar Lavage Fluid; Cell Movement; Collagen; Glycine; Leukocyt | 2012 |
The effects of the early administration of sivelestat sodium, a selective neutrophil elastase inhibitor, on the postoperative course after radical surgery for esophageal cancer.
Topics: Acute Lung Injury; Aged; C-Reactive Protein; Esophageal Neoplasms; Esophagectomy; Female; Glycine; H | 2012 |
Inhaled neutrophil elastase inhibitor reduces oleic acid-induced acute lung injury in rats.
Topics: Acute Lung Injury; Administration, Inhalation; Albumins; Animals; Blood Gas Analysis; Bronchoalveola | 2012 |
Effects of phorbol myristate acetate and sivelestat on the lung injury caused by fat embolism in isolated lungs.
Topics: Acute Lung Injury; Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Embolism, Fat; Gly | 2012 |
Combined effects of a neutrophil elastase inhibitor (sivelestat sodium) and a free radical scavenger (edaravone) on lipopolysaccharide-induced acute lung injury in rats.
Topics: Acute Lung Injury; Animals; Antipyrine; Drug Combinations; Edaravone; Free Radical Scavengers; Glyci | 2012 |
Clinical evaluation of sivelestat for acute lung injury/acute respiratory distress syndrome following surgery for abdominal sepsis.
Topics: Abdomen; Acute Lung Injury; Aged; Female; Glycine; Humans; Male; Middle Aged; Postoperative Complica | 2012 |
The propensity score analysis on the efficacy of sivelestat.
Topics: Acute Lung Injury; Female; Glycine; Humans; Male; Serine Proteinase Inhibitors; Sulfonamides; System | 2013 |
Sivelestat improves outcome of crush injury by inhibiting high-mobility group box 1 in rats.
Topics: Acute Lung Injury; Animals; Biomarkers; Carbon Dioxide; Combined Modality Therapy; Crush Syndrome; D | 2013 |