glycine and Inflammation studies

Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.

Research Excerpts

Excerpt	Relevance	Reference
" By combining the benefits of glycine, NAC and GSH, GlyNAC is an effective nutritional supplement that improves and reverses multiple age-associated abnormalities to promote health in aging humans."	9.69	Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial. ( Hsu, JW; Jahoor, F; Kumar, P; Liu, C; Minard, CG; Muthupillai, R; Sekhar, RV; Suliburk, J; Taffet, GE, 2023)
"We conducted a single-center, placebo-controlled, randomized study investigating 12 weeks of roflumilast treatment added to current therapy in moderate-to-severe COPD with chronic bronchitis."	9.20	A Randomized, Placebo-controlled Trial of Roflumilast. Effect on Proline-Glycine-Proline and Neutrophilic Inflammation in Chronic Obstructive Pulmonary Disease. ( Bailey, WC; Bhatt, SP; Blalock, JE; Dransfield, MT; Gaggar, A; Gautney, J; Handley, G; Jackson, PL; King, RW; Viera, L; Wells, JM; Xu, X, 2015)
"Glycine receptors (GlyRs) play key roles in the processing of inflammatory pain."	8.31	AAV-glycine receptor α3 alleviates CFA-induced inflammatory pain by downregulating ERK phosphorylation and proinflammatory cytokine expression in SD rats. ( Chang, LL; Cheng, KI; Kwan, AL; Tseng, KY; Wang, HC, 2023)
"5% of glyphosate (Roundup Original DI®) in drinking water or purified water (Glyphosate Group and Control Group respectively) during pregnancy and lactation."	8.12	Exposure to glyphosate-based herbicide during early stages of development increases insulin sensitivity and causes liver inflammation in adult mice offspring. ( Alegre-Maller, ACP; Amorim, JPA; Balbo, SL; Bonfleur, ML; Gomes, ECZ; Teleken, JL; Vargas, R, 2022)
" Here, we studied extracellular serine and serine/glycine metabolism using human keratinocytes, human skin biopsies, and a mouse model of psoriasis-like disease."	8.12	Extracellular serine empowers epidermal proliferation and psoriasis-like symptoms. ( Albanesi, C; Annicchiarico-Petruzzelli, M; Belardo, A; Candi, E; Cappello, A; Cutruzzolà, F; Jia, W; Madonna, S; Mancini, M; Melino, G; Pallotta, S; Panatta, E; Paone, A; Rinaldo, S; Scarponi, C; Wang, L; Zolla, L; Zuccotti, A, 2022)
" Here, we evaluated the anti-inflammatory Trimethylglycine and the Signal transducer and activator of transcription (STAT6) inhibitor AS1517499, as possible adjuvants to 5-FU in already established cancers, using a model of colitis-associated colon cancer (CAC)."	7.96	Use of STAT6 Phosphorylation Inhibitor and Trimethylglycine as New Adjuvant Therapies for 5-Fluorouracil in Colitis-Associated Tumorigenesis. ( Beristain-Terrazas, DL; Callejas, BE; Chirino, YI; Delgado-Buenrostro, NL; García-Castillo, V; Gutierrez-Cirlos, EB; León-Cabrera, SA; Mendoza-Rodríguez, MG; Meraz-Ríos, MA; Pérez-Plasencia, C; Rodríguez-Sosa, M; Sánchez-Barrera, CÁ; Terrazas, LI; Vaca-Paniagua, F, 2020)
"To explore the molecular mechanism of glycine in improving ischemic stroke."	7.96	Glycine Improves Ischemic Stroke Through miR-19a-3p/AMPK/GSK-3β/HO-1 Pathway. ( Chen, ZJ; Fan, TP; Li, D; Qi, HX; Zhao, XS, 2020)
"Our findings suggest that skeletal muscular glycine contributes to the antidepressant effects of ketamine in inflammation."	7.91	Contribution of skeletal muscular glycine to rapid antidepressant effects of ketamine in an inflammation-induced mouse model of depression. ( Hua, D; Hua, F; Huang, N; Jiang, R; Li, S; Luo, A; Wang, Y; Wu, Y; Yang, C; Yang, L; Yu, F; Zhan, G; Zhu, B, 2019)
" Because the involvement of local inhibition in the dorsal horn, specifically that mediated by the inhibitory amino acids GABA and glycine, is so important in signal processing, we investigated regional inhibitory control of excitatory interneurons under control conditions and peripheral inflammation-induced mechanical allodynia."	7.85	Inhibition Mediated by Glycinergic and GABAergic Receptors on Excitatory Neurons in Mouse Superficial Dorsal Horn Is Location-Specific but Modified by Inflammation. ( Choudhury, P; Conway, CM; Flood, PD; MacDermott, AB; Mukai, J; Scherrer, G; Takazawa, T; Tong, CK, 2017)
"Here we investigated for the first time the inhibitory potential of Glycine (Gly) against ethanol-induced oxidative stress, neuroinflammation and apoptotic neurodegeneration in human neuroblastoma SH-SY5Y cells and in the developing rat brain."	7.83	Glycine inhibits ethanol-induced oxidative stress, neuroinflammation and apoptotic neurodegeneration in postnatal rat brain. ( Amin, FU; Kim, MO; Shah, SA, 2016)
"Glycine protects skeletal muscle from cancer-induced wasting and loss of function, reduces the oxidative and inflammatory burden, and reduces the expression of genes associated with muscle protein breakdown in cancer cachexia."	7.80	Glycine administration attenuates skeletal muscle wasting in a mouse model of cancer cachexia. ( Chee, A; Ham, DJ; Koopman, R; Lynch, GS; Murphy, KT, 2014)
"The data indicate that preoperative glycine reduces postoperative ileus via the early attenuation of primal inflammatory events within the surgically manipulated gut wall."	7.77	Anti-inflammatory role of glycine in reducing rodent postoperative inflammatory ileus. ( Bauer, AJ; Kalff, JC; Moore, BA; Nazir, A; Schmidt, J; Schnurr, C; Stoffels, B; Tsukamoto, T; Türler, A, 2011)
"Hydrogen sulfide (H₂S), recently considered the third endogenous gaseous transmitter, may have an important role in systemic inflammation."	7.77	Involvement of endogenous hydrogen sulfide in cigarette smoke-induced changes in airway responsiveness and inflammation of rat lung. ( Chen, YH; He, YJ; Qi, YF; Tang, CS; Wang, PP; Wang, XM; Yao, WZ, 2011)
"In the present study we examined the effect of NA-glycine in a rat model of inflammatory pain."	7.74	Actions of N-arachidonyl-glycine in a rat inflammatory pain model. ( Mitchell, VA; Succar, R; Vaughan, CW, 2007)
" We have studied the effects on mechanical nociceptive thresholds in rats with carrageenin-induced paw inflammation of L-687,414, a low efficacy partial agonist which acts as a functional antagonist at the glycine modulatory site of the NMDA receptor and of L-701,324, a structurally novel, highly selective, full antagonist at this site."	7.69	Effects of a partial agonist and a full antagonist acting at the glycine site of the NMDA receptor on inflammation-induced mechanical hyperalgesia in rats. ( Hargreaves, RJ; Hill, RG; Laird, JM; Mason, GS; Webb, J, 1996)
"Glyphosate has been detected in urine, blood and maternal milk and has been found to induce the generation of reactive oxygen species (ROS) and several cytotoxic and genotoxic effects in vitro and in animal models directly or indirectly through its metabolite, aminomethylphosphonic acid (AMPA)."	6.72	Pleiotropic Outcomes of Glyphosate Exposure: From Organ Damage to Effects on Inflammation, Cancer, Reproduction and Development. ( Marino, M; Meccariello, R; Mele, E; Nori, SL; Santoro, A; Viggiano, A, 2021)
"Glyphosate is a herbicide which is commonly used in agricultural areas."	5.72	Effects of exposure to glyphosate on oxidative stress, inflammation, and lung function in maize farmers, Northern Thailand. ( Khacha-Ananda, S; Pothirat, C; Sapbamrer, R; Sidthilaw, S; Wunnapuk, K, 2022)
" By combining the benefits of glycine, NAC and GSH, GlyNAC is an effective nutritional supplement that improves and reverses multiple age-associated abnormalities to promote health in aging humans."	5.69	Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial. ( Hsu, JW; Jahoor, F; Kumar, P; Liu, C; Minard, CG; Muthupillai, R; Sekhar, RV; Suliburk, J; Taffet, GE, 2023)
"Glycine (Gly) has been reported to enhance the expression of tight-junction proteins in porcine enterocytes."	5.62	Dietary Supplementation with Glycine Enhances Intestinal Mucosal Integrity and Ameliorates Inflammation in C57BL/6J Mice with High-Fat Diet-Induced Obesity. ( Chen, J; Dai, Z; Kim, IH; Wu, G; Wu, Z; Yang, Y, 2021)
"Acute pancreatitis was induced in mice by 10 hourly intraperitoneal injections of caerulein (50 (g/kg)."	5.35	Pro-inflammatory effects of hydrogen sulphide on substance P in caerulein-induced acute pancreatitis. ( Bhatia, M; Moochhala, SM; Ng, SW; Sidhapuriwala, JN; Tamizhselvi, R, 2008)
"We previously demonstrated that a novel hydrophilic gamma-tocopherol (gamma-Toc) derivative, gamma-tocopherol-N,N-dimethylglycinate hydrochloride (gamma-TDMG) converts to gamma-Toc in the mouse skin and has a higher bioavailability than gamma-Toc itself."	5.33	Topical application of a novel, hydrophilic gamma-tocopherol derivative reduces photo-inflammation in mice skin. ( Karube, Y; Kobayashi, S; Takata, J; Watanabe, T; Yamazaki, A; Yoshida, E, 2006)
"Glycine effects were also investigated in vivo by treating rats with a diet containing glycine (5%) during 3 days."	5.33	Insight into the involvement of Kupffer cell-derived mediators in the hepatoprotective effect of glycine upon inflammation: study on rat precision-cut liver slices. ( Delzenne, NM; Margagliotti, S; Neyrinck, AM, 2005)
"We conducted a single-center, placebo-controlled, randomized study investigating 12 weeks of roflumilast treatment added to current therapy in moderate-to-severe COPD with chronic bronchitis."	5.20	A Randomized, Placebo-controlled Trial of Roflumilast. Effect on Proline-Glycine-Proline and Neutrophilic Inflammation in Chronic Obstructive Pulmonary Disease. ( Bailey, WC; Bhatt, SP; Blalock, JE; Dransfield, MT; Gaggar, A; Gautney, J; Handley, G; Jackson, PL; King, RW; Viera, L; Wells, JM; Xu, X, 2015)
"We investigated changes to the leukotriene A4 hydrolase (LTA4H)-proline-glycine-proline (PGP) pathway and chronic inflammation in the development of COPD."	5.19	An aberrant leukotriene A4 hydrolase-proline-glycine-proline pathway in the pathogenesis of chronic obstructive pulmonary disease. ( Blalock, JE; Gaggar, A; Garrett, C; Handley, G; Jackson, PL; McNicholas, CM; Miller, BE; O'Reilly, PJ; Rennard, SI; Roda, MA; Sullivan, DI; Szul, T; Tal-Singer, R; Wells, JM, 2014)
" Sivelestat has been used clinically to treat acute lung injury associated with systemic inflammatory response syndrome."	5.17	Neutrophil elastase inhibitor sivelestat attenuates perioperative inflammatory response in pediatric heart surgery with cardiopulmonary bypass. ( Inoue, N; Itatani, K; Kitamura, T; Miyaji, K; Oka, N; Shibata, K; Tomoyasu, T, 2013)
" Guanidinosuccinate correlated positively with plasma urea and negatively with inflammation markers."	5.13	Guanidino compounds after creatine supplementation in renal failure patients and their relation to inflammatory status. ( De Deyn, PP; De Vriese, A; Delanghe, JR; Marescau, B; Schepers, E; Taes, YE; Vanholder, R, 2008)
"Glycine protects against shock caused by hemorrhage, endotoxin and sepsis, prevents ischemia/reperfusion and cold storage/reperfusion injury to a variety of tissues and organs including liver, kidney, heart, intestine and skeletal muscle, and diminishes liver and renal injury caused by hepatic and renal toxicants and drugs."	4.82	L-Glycine: a novel antiinflammatory, immunomodulatory, and cytoprotective agent. ( Bradford, B; Bunzendaul, H; Froh, M; Lemasters, JJ; Li, X; Schemmer, P; Wheeler, MD; Yin, M; Zhong, Z, 2003)
"Glycine receptors (GlyRs) play key roles in the processing of inflammatory pain."	4.31	AAV-glycine receptor α3 alleviates CFA-induced inflammatory pain by downregulating ERK phosphorylation and proinflammatory cytokine expression in SD rats. ( Chang, LL; Cheng, KI; Kwan, AL; Tseng, KY; Wang, HC, 2023)
" Altered energy metabolism and lower cytoprotective activity (histidine, glycine, arginine) indicated vulnerability to develop intestinal inflammation in PCeD over time."	4.12	NMR based metabolic profiling of patients with potential celiac disease elucidating early biochemical changes of gluten-sensitivity: A pilot study. ( Das, P; Dattagupta, S; Jagannathan, NR; Makharia, GK; Sharma, U; Upadhyay, D, 2022)
"5% of glyphosate (Roundup Original DI®) in drinking water or purified water (Glyphosate Group and Control Group respectively) during pregnancy and lactation."	4.12	Exposure to glyphosate-based herbicide during early stages of development increases insulin sensitivity and causes liver inflammation in adult mice offspring. ( Alegre-Maller, ACP; Amorim, JPA; Balbo, SL; Bonfleur, ML; Gomes, ECZ; Teleken, JL; Vargas, R, 2022)
" Here, we studied extracellular serine and serine/glycine metabolism using human keratinocytes, human skin biopsies, and a mouse model of psoriasis-like disease."	4.12	Extracellular serine empowers epidermal proliferation and psoriasis-like symptoms. ( Albanesi, C; Annicchiarico-Petruzzelli, M; Belardo, A; Candi, E; Cappello, A; Cutruzzolà, F; Jia, W; Madonna, S; Mancini, M; Melino, G; Pallotta, S; Panatta, E; Paone, A; Rinaldo, S; Scarponi, C; Wang, L; Zolla, L; Zuccotti, A, 2022)
"The liver expression levels of APOA1bp were associated with lower cIMT and leukocyte counts, a better plasma lipid profile and higher circulating levels of metabolites associated with lower risk of atherosclerosis (glycine, histidine and asparagine)."	3.96	The APOA1bp-SREBF-NOTCH axis is associated with reduced atherosclerosis risk in morbidly obese patients. ( Barton, RH; Burcelin, R; Dumas, ME; Federici, M; Fernández-Real, JM; Hoyles, L; Mayneris-Perxachs, J; Puig, J, 2020)
" Here, we evaluated the anti-inflammatory Trimethylglycine and the Signal transducer and activator of transcription (STAT6) inhibitor AS1517499, as possible adjuvants to 5-FU in already established cancers, using a model of colitis-associated colon cancer (CAC)."	3.96	Use of STAT6 Phosphorylation Inhibitor and Trimethylglycine as New Adjuvant Therapies for 5-Fluorouracil in Colitis-Associated Tumorigenesis. ( Beristain-Terrazas, DL; Callejas, BE; Chirino, YI; Delgado-Buenrostro, NL; García-Castillo, V; Gutierrez-Cirlos, EB; León-Cabrera, SA; Mendoza-Rodríguez, MG; Meraz-Ríos, MA; Pérez-Plasencia, C; Rodríguez-Sosa, M; Sánchez-Barrera, CÁ; Terrazas, LI; Vaca-Paniagua, F, 2020)
"Plasma acylcarnitines [(C2, C16:1, C18, C18:1, C18:1-OH, and C18:2)], glycerophospholipids (lysophosphatidylcholine-acyl, -di-acyl, and -di-acyl acyl-alkyl) and sphingomyelins [SM (OH) C16:1, SM C18:0, SM C18:1, and SM C20:2] significantly increased on PND 145, when chronic inflammation was observed in the dorsolateral prostate of rats dosed with EB, T, and E."	3.96	Distinct lipid signatures are identified in the plasma of rats with chronic inflammation induced by estradiol benzoate and sex hormones. ( Beger, RD; Cao, Z; Nakamura, N; Pence, LM, 2020)
"To explore the molecular mechanism of glycine in improving ischemic stroke."	3.96	Glycine Improves Ischemic Stroke Through miR-19a-3p/AMPK/GSK-3β/HO-1 Pathway. ( Chen, ZJ; Fan, TP; Li, D; Qi, HX; Zhao, XS, 2020)
"Our findings suggest that skeletal muscular glycine contributes to the antidepressant effects of ketamine in inflammation."	3.91	Contribution of skeletal muscular glycine to rapid antidepressant effects of ketamine in an inflammation-induced mouse model of depression. ( Hua, D; Hua, F; Huang, N; Jiang, R; Li, S; Luo, A; Wang, Y; Wu, Y; Yang, C; Yang, L; Yu, F; Zhan, G; Zhu, B, 2019)
" Because the involvement of local inhibition in the dorsal horn, specifically that mediated by the inhibitory amino acids GABA and glycine, is so important in signal processing, we investigated regional inhibitory control of excitatory interneurons under control conditions and peripheral inflammation-induced mechanical allodynia."	3.85	Inhibition Mediated by Glycinergic and GABAergic Receptors on Excitatory Neurons in Mouse Superficial Dorsal Horn Is Location-Specific but Modified by Inflammation. ( Choudhury, P; Conway, CM; Flood, PD; MacDermott, AB; Mukai, J; Scherrer, G; Takazawa, T; Tong, CK, 2017)
"As an effective COX-2 inhibitor, celecoxib is widely used in anti-inflammation therapy."	3.85	Enhanced Anti-Inflammatory Efficacy Through Targeting to Macrophages: Synthesis and In Vitro Evaluation of Folate-Glycine-Celecoxib. ( Li, Y; Xiao, Y; Yin, Z, 2017)
" In this study, we investigated the dynamics of AnxA1 expression and the effects of synthetic (sivelestat [SIV]; Eglin) and natural (secretory leukocyte protease inhibitor [SLPI]; Elafin) protease inhibitors on the resolution of LPS-induced inflammation."	3.83	Proresolving Actions of Synthetic and Natural Protease Inhibitors Are Mediated by Annexin A1. ( Carneiro, FS; de Caux, TR; Galvão, I; Lima, GL; Lima, KM; Nunes, FF; Perretti, M; Pinho, V; Ribeiro, AL; Sousa, LP; Sugimoto, MA; Tavares, LP; Teixeira, MM; Vago, JP, 2016)
" Since we demonstrated that glycine supplementation can reduce inflammation and muscle wasting, we hypothesized that glycine supplementation during CR would preserve muscle mass in mice."	3.83	Glycine supplementation during calorie restriction accelerates fat loss and protects against further muscle loss in obese mice. ( Caldow, MK; Chee, A; Godeassi, DP; Ham, DJ; Koopman, R; Lynch, GS, 2016)
"Here we investigated for the first time the inhibitory potential of Glycine (Gly) against ethanol-induced oxidative stress, neuroinflammation and apoptotic neurodegeneration in human neuroblastoma SH-SY5Y cells and in the developing rat brain."	3.83	Glycine inhibits ethanol-induced oxidative stress, neuroinflammation and apoptotic neurodegeneration in postnatal rat brain. ( Amin, FU; Kim, MO; Shah, SA, 2016)
"These findings showed for the first time that arginine 213 in the HBD of SOD3 is critical for maintaining proper organ function through moderating the normal innate immune response, which would otherwise lead to chronic inflammation and degenerative diseases in aged mice."	3.81	SOD3 Variant, R213G, Altered SOD3 Function, Leading to ROS-Mediated Inflammation and Damage in Multiple Organs of Premature Aging Mice. ( Kim, JH; Kim, TY; Kwon, MJ; Lee, HW; Lee, KY, 2015)
" Colonic delivery of celecoxib elicits anticolitic effects in a trinitrobenzene sulfonic acid-induced rat colitis model."	3.81	Evaluation of glycine-bearing celecoxib derivatives as a colon-specific mutual prodrug acting on nuclear factor-κB, an anti-inflammatory target. ( Jeong, S; Jung, Y; Kim, MS; Kim, W; Lee, S; Lee, Y; Moon, HR; Nam, J; Yoo, JW, 2015)
"Glycine protects skeletal muscle from cancer-induced wasting and loss of function, reduces the oxidative and inflammatory burden, and reduces the expression of genes associated with muscle protein breakdown in cancer cachexia."	3.80	Glycine administration attenuates skeletal muscle wasting in a mouse model of cancer cachexia. ( Chee, A; Ham, DJ; Koopman, R; Lynch, GS; Murphy, KT, 2014)
" The aim of this study was to determine effects of inhibiting hydrogen sulphide biosynthesis by DL-propargyl glycine (an irreversible inhibitor of cystathionine gamma-lyase) on inflammation, necrosis and renal function, following treatment with gentamicin in rats."	3.78	Inhibition of cystathionine gamma-lyase and the biosynthesis of endogenous hydrogen sulphide ameliorates gentamicin-induced nephrotoxicity. ( Dam, VP; Kinobe, RT; Ross, A; Scott, JL, 2012)
"The data indicate that preoperative glycine reduces postoperative ileus via the early attenuation of primal inflammatory events within the surgically manipulated gut wall."	3.77	Anti-inflammatory role of glycine in reducing rodent postoperative inflammatory ileus. ( Bauer, AJ; Kalff, JC; Moore, BA; Nazir, A; Schmidt, J; Schnurr, C; Stoffels, B; Tsukamoto, T; Türler, A, 2011)
"Hydrogen sulfide (H₂S), recently considered the third endogenous gaseous transmitter, may have an important role in systemic inflammation."	3.77	Involvement of endogenous hydrogen sulfide in cigarette smoke-induced changes in airway responsiveness and inflammation of rat lung. ( Chen, YH; He, YJ; Qi, YF; Tang, CS; Wang, PP; Wang, XM; Yao, WZ, 2011)
": A neutrophil elastase (NE) inhibitor, Sivelestat, has been approved for the treatment of acute lung injury associated with systemic inflammation in humans."	3.76	The protective function of neutrophil elastase inhibitor in liver ischemia/reperfusion injury. ( Busuttil, RW; Freitas, MC; Kupiec-Weglinski, JW; Uchida, Y; Zhao, D, 2010)
"In this study, the effect of (S)-3,4-dicarboxyphenylglycine (DCPG), a selective mGlu8 receptor agonist, has been investigated in inflammatory and neuropathic pain models in order to elucidate the role of mGlu8 receptor in modulating pain perception."	3.74	Effects of (S)-3,4-DCPG, an mGlu8 receptor agonist, on inflammatory and neuropathic pain in mice. ( de Novellis, V; Maione, S; Marabese, I; Palazzo, E; Rossi, F; Scafuro, MA; Vita, D, 2007)
" This efficient route enabled to scale up the synthesis of an orally bioavailable glycine antagonist showing outstanding in vivo anti-hyperalgesic activity in different animal models of sustained inflammation and chronic neuropathic pain."	3.74	Chiral tetrahydroquinoline derivatives as potent anti-hyperalgesic agents in animal models of sustained inflammation and chronic neuropathic pain. ( Alvaro, G; Barnaby, RJ; Bertani, B; Corsi, M; Di Fabio, R; Donati, D; Gentile, G; Giacobbe, S; Pentassuglia, G; Pizzi, DM; Quartaroli, M; Ratti, E; Spada, S; Vitulli, G, 2007)
"In the present study we examined the effect of NA-glycine in a rat model of inflammatory pain."	3.74	Actions of N-arachidonyl-glycine in a rat inflammatory pain model. ( Mitchell, VA; Succar, R; Vaughan, CW, 2007)
"The present study investigated the hypothesis that hydrogen sulfide (H2S) is pro-nociceptive in the formalin model of persistent inflammatory pain in the adult rat."	3.74	A nociceptive-intensity-dependent role for hydrogen sulphide in the formalin model of persistent inflammatory pain. ( Cheng, Y; Khanna, S; Lee, AT; Li, L; Moore, PK; Shah, JJ, 2008)
" This study examined the effects of the metabotropic glutamate receptor agonists (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid ((1S,3R)-ACPD), (S)-3,5-dihydroxyphenylglycine ((S)-3,5-DHPG) and (1S,3S)-1-aminocyclopentane-1,3-dicarboxylic acid ((1S,3S)-ACPD) on the electrically evoked responses of dorsal horn neurones recorded in normal animals and in animals 3 h after the induction of carrageenan inflammation."	3.70	Inflammation alters the effects of mGlu receptor agonists on spinal nociceptive neurones. ( Dickenson, AH; Stanfa, LC, 1998)
" We have studied the effects on mechanical nociceptive thresholds in rats with carrageenin-induced paw inflammation of L-687,414, a low efficacy partial agonist which acts as a functional antagonist at the glycine modulatory site of the NMDA receptor and of L-701,324, a structurally novel, highly selective, full antagonist at this site."	3.69	Effects of a partial agonist and a full antagonist acting at the glycine site of the NMDA receptor on inflammation-induced mechanical hyperalgesia in rats. ( Hargreaves, RJ; Hill, RG; Laird, JM; Mason, GS; Webb, J, 1996)
"ST 679 dose-dependently inhibited carrageenan-, concanavalin A-, and nystatin-induced oedema."	3.68	Profile of activity of a new anti-inflammatory agent, ST 679 (MED 15). ( Arrigoni-Martelli, E, 1990)
"Glycine is a non-essential amino acid with many functions and effects."	3.01	Glycine: The Smallest Anti-Inflammatory Micronutrient. ( Acevedo-Villavicencio, LN; Aguayo-Cerón, KA; Flores-Zarate, AV; Giacoman-Martinez, A; Gutierrez-Rojas, RA; Huang, F; Romero-Nava, R; Sánchez-Muñoz, F; Villafaña, S, 2023)
"Glyphosate has been detected in urine, blood and maternal milk and has been found to induce the generation of reactive oxygen species (ROS) and several cytotoxic and genotoxic effects in vitro and in animal models directly or indirectly through its metabolite, aminomethylphosphonic acid (AMPA)."	2.72	Pleiotropic Outcomes of Glyphosate Exposure: From Organ Damage to Effects on Inflammation, Cancer, Reproduction and Development. ( Marino, M; Meccariello, R; Mele, E; Nori, SL; Santoro, A; Viggiano, A, 2021)
"Glycine has been well characterized in spinal cord as an inhibitory neurotransmitter which activates a glycine-gated chloride channel (GlyR) expressed in postsynaptic membranes."	2.40	Glycine: a new anti-inflammatory immunonutrient. ( Bradford, B; Enomoto, N; Ikejema, K; Rose, ML; Rusyn, I; Schemmer, P; Seabra, V; Stacklewitz, RF; Thurman, RG; Wheeler, MD; Yin, M; Zhong, Z, 1999)
"Glyphosate is a herbicide which is commonly used in agricultural areas."	1.72	Effects of exposure to glyphosate on oxidative stress, inflammation, and lung function in maize farmers, Northern Thailand. ( Khacha-Ananda, S; Pothirat, C; Sapbamrer, R; Sidthilaw, S; Wunnapuk, K, 2022)
"Sepsis is a life-threatening organ dysfunction caused by dysregulated host response to an infection."	1.72	Dichloroacetate improves systemic energy balance and feeding behavior during sepsis. ( Jain, S; Long, D; McCall, CE; Oh, TS; Quinn, MA; Stacpoole, PW; Zabalawi, M, 2022)
"Glycine (Gly) has been reported to enhance the expression of tight-junction proteins in porcine enterocytes."	1.62	Dietary Supplementation with Glycine Enhances Intestinal Mucosal Integrity and Ameliorates Inflammation in C57BL/6J Mice with High-Fat Diet-Induced Obesity. ( Chen, J; Dai, Z; Kim, IH; Wu, G; Wu, Z; Yang, Y, 2021)
"Glyphosate (Gly) is an active ingredient of herbicide, its underlying toxicity on fish is still unclear."	1.62	Effects of chronic glyphosate exposure on antioxdative status, metabolism and immune response in tilapia (GIFT, Oreochromis niloticus). ( Cao, L; Du, J; Gu, Z; He, Q; Jia, R; Xu, P; Yin, G; Zheng, T, 2021)
"Glycine (Gly) has been reported to have antioxidative and anti-inflammatory effects and to regulate apoptosis in various models."	1.56	Glycine Attenuates LPS-Induced Apoptosis and Inflammatory Cell Infiltration in Mouse Liver. ( Chen, J; Dai, Z; Jia, H; Jin, Y; Liu, N; Wang, C; Wu, G; Wu, Z; Yang, Y; Zhang, Y, 2020)
"Treatment with SR9009 also blocked tumor necrosis factor-induced IL-1β mRNA, IL-6 mRNA and MMP-9 mRNA."	1.51	Stimulation of nuclear receptor REV-ERBs suppresses production of pronociceptive molecules in cultured spinal astrocytes and ameliorates mechanical hypersensitivity of inflammatory and neuropathic pain of mice. ( Hisaoka-Nakashima, K; Kodama, K; Morioka, N; Nakamura, Y; Nakata, Y; Saeki, M; Tomori, M; Yoshikawa, K; Zhang, FF, 2019)
"Cholestasis is the stoppage of bile flow which could lead to serious clinical complications if not managed."	1.48	Mitochondria protection as a mechanism underlying the hepatoprotective effects of glycine in cholestatic mice. ( Abdoli, N; Aghaei, F; Ahmadi, A; Azarpira, N; Esfandiari, A; Ghanbarinejad, V; Heidari, R; Mohammadi, H; Niknahad, H; Ommati, MM, 2018)
"Rat acute inflammation was induced by subcutaneous injection of carrageenan in hind paws."	1.42	The investigation of anti-inflammatory activity of volatile oil of Angelica sinensis by plasma metabolomics approach. ( Hua, Y; Ji, P; Li, J; Li, P; Wei, Y; Yao, W; Zhang, L; Zhao, H; Zhong, L, 2015)
"Sivelestat was administered immediately before and 1 h after irradiation in group RE2, and immediately before and 1, 3 and 6 h after irradiation in group RE4."	1.39	Sivelestat sodium hydrate reduces radiation-induced lung injury in mice by inhibiting neutrophil elastase. ( Akita, K; Inomata, T; Narumi, Y; Okada, Y; Shimbo, T; Takahashi, M; Uesugi, Y; Yoshikawa, N, 2013)
"Sivelestat is a specific neutrophil elastase inhibitor, which has been developed in Japan in 1991."	1.39	Protective effects of sivelestat in a caerulein-induced rat acute pancreatitis model. ( Cao, J; Liu, Q, 2013)
"In the bleomycin-induced early-stage pulmonary fibrosis model, the neutrophil elastase level was increased in the lungs."	1.38	A neutrophil elastase inhibitor prevents bleomycin-induced pulmonary fibrosis in mice. ( Fukuda, T; Ishii, Y; Takemasa, A, 2012)
"Treatment with sivelestat significantly improved the survival rate of the post-CLP septic animals (P = 0."	1.36	Neutrophil elastase inhibitor improves survival of rats with clinically relevant sepsis. ( Fukunaga, K; Funakoshi, Y; Hagiwara, T; Hashimoto, S; Ishizaka, A; Kawasako, K; Kitagawa, Y; Maruyama, I; Miyasho, T; Okamoto, M; Saikawa, Y; Suda, K; Suganuma, K; Takeuchi, H; Wada, N; Yamada, S; Yokota, H, 2010)
"Sivelestat sodium was administered within 24 h after the onset of respiratory dysfunction in 87."	1.36	A survey of the effects of sivelestat sodium administration on patients with postoperative respiratory dysfunction. ( Harada, N; Harimoto, N; Kakeji, Y; Koga, T; Maehara, Y; Miyazaki, M; Morita, M; Nagata, S; Oki, E; Saeki, H, 2010)
"Endotoxic shock is a systemic inflammatory response that is associated with an increase in nitric oxide production and a decrease in the formation of 20-hydroxyeicosatetraenoic acid (20-HETE), which may contribute to the fall in blood pressure and vascular reactivity."	1.35	A 20-hydroxyeicosatetraenoic acid agonist, N-[20-hydroxyeicosa-5(Z),14(Z)-dienoyl]glycine, opposes the fall in blood pressure and vascular reactivity in endotoxin-treated rats. ( Anjaiah, S; Buharalioglu, CK; Falck, J; Firat, SS; Korkmaz, B; Malik, KU; Roman, RJ; Tunctan, B, 2008)
"Acute pancreatitis was induced in mice by 10 hourly intraperitoneal injections of caerulein (50 (g/kg)."	1.35	Pro-inflammatory effects of hydrogen sulphide on substance P in caerulein-induced acute pancreatitis. ( Bhatia, M; Moochhala, SM; Ng, SW; Sidhapuriwala, JN; Tamizhselvi, R, 2008)
"Glycine effects were also investigated in vivo by treating rats with a diet containing glycine (5%) during 3 days."	1.33	Insight into the involvement of Kupffer cell-derived mediators in the hepatoprotective effect of glycine upon inflammation: study on rat precision-cut liver slices. ( Delzenne, NM; Margagliotti, S; Neyrinck, AM, 2005)
"We previously demonstrated that a novel hydrophilic gamma-tocopherol (gamma-Toc) derivative, gamma-tocopherol-N,N-dimethylglycinate hydrochloride (gamma-TDMG) converts to gamma-Toc in the mouse skin and has a higher bioavailability than gamma-Toc itself."	1.33	Topical application of a novel, hydrophilic gamma-tocopherol derivative reduces photo-inflammation in mice skin. ( Karube, Y; Kobayashi, S; Takata, J; Watanabe, T; Yamazaki, A; Yoshida, E, 2006)
" Unlike morphine, CHF3381 chronic administration was not accompanied by the development of tolerance in the formalin test."	1.32	Antinociceptive activity of the N-methyl-D-aspartate receptor antagonist N-(2-Indanyl)-glycinamide hydrochloride (CHF3381) in experimental models of inflammatory and neuropathic pain. ( Barbieri, M; Bassani, F; Bergamaschi, M; Bolzoni, PT; Chamiot-Clerc, P; Maiorino, M; Pietra, C; Rondelli, I; Simonato, M; Villetti, G, 2003)

Research

Studies (162)

Authors

Clinical Trials (13)

Trial Overview

Trial Outcomes

Changes in Serum Concentration of Inflammatory Biomarkers (TNF-alpha)

Timeframe	Studies, this research(%)	All Research%
pre-1990	12 (7.41)	18.7374
1990's	8 (4.94)	18.2507
2000's	44 (27.16)	29.6817
2010's	73 (45.06)	24.3611
2020's	25 (15.43)	2.80

Authors	Studies
Chen, J	4
Li, Z	1
Zhang, H	2
Hu, J	2
Wang, J	1
Zhou, H	1
Liu, Y	2
Liu, J	2
Yi, B	1
Zhang, W	4
Marino, M	1
Mele, E	1
Viggiano, A	1
Nori, SL	1
Meccariello, R	1
Santoro, A	1
Upadhyay, D	1
Das, P	1
Dattagupta, S	1
Makharia, GK	1
Jagannathan, NR	1
Sharma, U	1
Gomes, ECZ	1
Teleken, JL	1
Vargas, R	1
Alegre-Maller, ACP	1
Amorim, JPA	1
Bonfleur, ML	1
Balbo, SL	1
Oh, TS	1
Zabalawi, M	1
Jain, S	1
Long, D	1
Stacpoole, PW	1
McCall, CE	1
Quinn, MA	1
Sidthilaw, S	1
Sapbamrer, R	1
Pothirat, C	1
Wunnapuk, K	1
Khacha-Ananda, S	1
Johnstone, MA	1
Self, WT	1
Kumar, P	3
Liu, C	3
Suliburk, J	1
Hsu, JW	2
Muthupillai, R	1
Jahoor, F	3
Minard, CG	1
Taffet, GE	2
Sekhar, RV	4
Morozova, MV	1
Borisova, MA	1
Snytnikova, OA	1
Achasova, KM	1
Litvinova, EA	1
Tsentalovich, YP	1
Kozhevnikova, EN	1
Cappello, A	2
Mancini, M	2
Madonna, S	2
Rinaldo, S	2
Paone, A	2
Scarponi, C	2
Belardo, A	2
Zolla, L	2
Zuccotti, A	2
Panatta, E	2
Pallotta, S	2
Annicchiarico-Petruzzelli, M	2
Albanesi, C	2
Cutruzzolà, F	2
Wang, L	2
Jia, W	3
Melino, G	2
Candi, E	2
Wang, HC	1
Cheng, KI	1
Tseng, KY	1
Kwan, AL	1
Chang, LL	1
Aguayo-Cerón, KA	1
Sánchez-Muñoz, F	1
Gutierrez-Rojas, RA	1
Acevedo-Villavicencio, LN	1
Flores-Zarate, AV	1
Huang, F	1
Giacoman-Martinez, A	1
Villafaña, S	1
Romero-Nava, R	1
Zheng, C	1
Zhong, Y	1
Wang, Z	1
Xiao, H	1
Xie, J	1
Peng, X	1
Luo, J	1
Xu, W	1
Ying, R	1
Zhang, Z	2
Zhu, H	2
Li, B	1
Hou, H	1
Zhang, Y	3
Chang, Y	1
Yang, T	1
Wen, M	1
Liu, G	1
Zhao, H	2
Chen, X	1
Tian, G	1
Cai, J	2
Wu, B	1
Jia, G	1
Garattini, EG	1
Santos, BM	1
Ferrari, DP	1
Capel, CP	1
Francescato, HDC	1
Coimbra, TM	3
Leite-Panissi, CRA	1
Branco, LGS	1
Nascimento, GC	1
Raevens, S	1
Van Campenhout, S	1
Debacker, PJ	1
Lefere, S	1
Verhelst, X	1
Geerts, A	1
Van Vlierberghe, H	1
Colle, I	1
Devisscher, L	1
Jia, H	2
Jin, Y	1
Liu, N	1
Yang, Y	4
Dai, Z	2
Wang, C	1
Wu, G	2
Wu, Z	3
Mayneris-Perxachs, J	1
Puig, J	1
Burcelin, R	1
Dumas, ME	1
Barton, RH	1
Hoyles, L	1
Federici, M	1
Fernández-Real, JM	2
Mendoza-Rodríguez, MG	1
Sánchez-Barrera, CÁ	1
Callejas, BE	1
García-Castillo, V	1
Beristain-Terrazas, DL	1
Delgado-Buenrostro, NL	1
Chirino, YI	1
León-Cabrera, SA	1
Rodríguez-Sosa, M	1
Gutierrez-Cirlos, EB	1
Pérez-Plasencia, C	1
Vaca-Paniagua, F	1
Meraz-Ríos, MA	1
Terrazas, LI	1
Chen, ZJ	1
Zhao, XS	1
Fan, TP	1
Qi, HX	1
Li, D	1
Zheng, T	1
Jia, R	1
Cao, L	1
Du, J	2
Gu, Z	1
He, Q	1
Xu, P	1
Yin, G	1
Nakamura, N	1
Pence, LM	1
Cao, Z	1
Beger, RD	1
Chacko, S	1
Minard, C	1
Pandher, U	1
Kirychuk, S	1
Schneberger, D	1
Thompson, B	1
Aulakh, G	1
Sethi, RS	1
Singh, B	1
Kim, IH	1
Short, VL	1
Hoffman, M	1
Metgud, M	1
Kavi, A	1
Goudar, SS	1
Okitawutshu, J	1
Tshefu, A	1
Bose, CL	1
Mwenechanya, M	1
Chomba, E	1
Carlo, WA	1
Figueroa, L	1
Garces, A	1
Krebs, NF	1
Jessani, S	1
Saleem, S	1
Goldenberg, RL	1
Das, PK	1
Patel, A	1
Hibberd, PL	1
Achieng, E	1
Nyongesa, P	1
Esamai, F	1
Bucher, S	1
Nowak, KJ	1
Goco, N	1
Nolen, TL	1
McClure, EM	1
Koso-Thomas, M	1
Miodovnik, M	1
Derman, RJ	1
Li, W	1
Ten, LN	1
Kim, MK	1
Lee, SY	1
Jung, HY	1
Mu, T	1
Oscilowska, I	1
Huynh, TYL	1
Baszanowska, W	1
Prokop, I	1
Surazynski, A	1
Galli, M	1
Zabielski, P	1
Palka, J	1
Martin, FP	1
Su, MM	1
Xie, GX	1
Guiraud, SP	1
Kussmann, M	1
Godin, JP	1
Nydegger, A	1
Heidari, R	1
Ghanbarinejad, V	1
Mohammadi, H	1
Ahmadi, A	1
Ommati, MM	1
Abdoli, N	1
Aghaei, F	1
Esfandiari, A	1
Azarpira, N	1
Niknahad, H	1
Mavuso, S	1
Marimuthu, T	1
Kondiah, PPD	1
du Toit, LC	1
Choonara, YE	1
Pillay, V	1
Ostojic, SM	1
Trivic, T	1
Drid, P	1
Stajer, V	1
Vranes, M	1
Vargas, MH	1
Del-Razo-Rodríguez, R	1
López-García, A	1
Lezana-Fernández, JL	1
Chávez, J	1
Furuya, MEY	1
Marín-Santana, JC	1
Cieslik, KA	1
Granillo, A	1
Reddy, A	1
Medrano, G	1
Heredia, CP	1
Entman, ML	1
Hamilton, DJ	1
Li, S	3
Reineke, E	1
Gupte, AA	1
Zhang, A	1
Tsang, YC	1
Corbet, EF	1
Jin, LJ	1
Guo, DK	1
Zhu, Y	1
Sun, HY	1
Xu, XY	1
Zhang, S	1
Hao, ZB	1
Wang, GH	1
Mu, CC	1
Ren, HG	1
Niu, C	1
Wang, T	1
Zou, W	1
Ying, L	1
Zhang, M	1
Tian, D	1
Dai, J	1
Luo, Z	1
Liu, E	1
Zou, L	1
Xiong, Y	1
Fu, Z	1
Xu, X	2
Wang, X	1
Wu, H	1
Hou, Y	1
Dai, B	1
Liu, X	1
Yao, W	2
Wu, S	1
Han, X	1
Guan, J	1
Yuan, D	1
Hei, Z	1
Tarasuntisuk, S	1
Palaga, T	1
Kageyama, H	1
Waditee-Sirisattha, R	1
Morioka, N	1
Kodama, K	1
Tomori, M	1
Yoshikawa, K	1
Saeki, M	1
Nakamura, Y	1
Zhang, FF	1
Hisaoka-Nakashima, K	1
Nakata, Y	1
George, L	1
Ramasamy, T	1
Sirajudeen, K	1
Manickam, V	1
Comas, F	1
Latorre, J	1
Cussó, O	1
Ortega, F	1
Lluch, A	1
Sabater, M	1
Castells-Nobau, A	1
Ricart, W	1
Ribas, X	1
Costas, M	1
Moreno-Navarrete, JM	1
de Souza, JS	1
Laureano-Melo, R	1
Herai, RH	1
da Conceição, RR	1
Oliveira, KC	1
da Silva, IDCG	1
Dias-da-Silva, MR	1
Romano, RM	1
Romano, MA	1
Maciel, RMB	1
Chiamolera, MI	1
Giannocco, G	1
Huang, N	1
Wang, Y	1
Zhan, G	1
Yu, F	1
Hua, D	1
Jiang, R	1
Wu, Y	1
Yang, L	1
Zhu, B	1
Hua, F	1
Luo, A	1
Yang, C	1
Yoshikawa, N	1
Inomata, T	1
Okada, Y	1
Shimbo, T	1
Takahashi, M	2
Akita, K	1
Uesugi, Y	1
Narumi, Y	1
Paukkeri, EL	1
Leppänen, T	1
Lindholm, M	1
Yam, MF	1
Asmawi, MZ	1
Kolmonen, A	1
Aulaskari, PH	1
Moilanen, E	1
Inoue, N	3
Oka, N	3
Kitamura, T	3
Shibata, K	1
Itatani, K	3
Tomoyasu, T	1
Miyaji, K	3
Hartog, A	2
Cozijnsen, M	1
de Vrij, G	1
Garssen, J	2
Cao, J	1
Liu, Q	1
Kohira, S	2
Hanayama, N	1
Fujii, M	1
Takeda, A	1
Oshima, H	2
Tojo, K	2
Yoshitake, S	2
Ham, DJ	2
Murphy, KT	1
Chee, A	2
Lynch, GS	2
Koopman, R	2
Dort, J	1
Leblanc, N	1
Maltais-Giguère, J	1
Liaset, B	1
Côté, CH	1
Jacques, H	1
Dhaneshwar, S	1
Kusurkar, M	1
Bodhankar, S	1
Bihani, G	1
Sato, S	1
Sakurai, T	1
Ogasawara, J	1
Izawa, T	1
Imaizumi, K	1
Taniguchi, N	1
Ohno, H	1
Kizaki, T	1
Wonnerth, A	1
Katsaros, KM	1
Krychtiuk, KA	1
Speidl, WS	1
Kaun, C	1
Thaler, K	1
Huber, K	1
Wojta, J	1
Maurer, G	1
Seljeflot, I	1
Arnesen, H	1
Weiss, TW	1
Horai, T	1
Wells, JM	2
O'Reilly, PJ	1
Szul, T	1
Sullivan, DI	1
Handley, G	2
Garrett, C	1
McNicholas, CM	1
Roda, MA	1
Miller, BE	1
Tal-Singer, R	1
Gaggar, A	2
Rennard, SI	1
Jackson, PL	2
Blalock, JE	2
Zhou, X	1
Chen, K	1
Lei, H	1
Sun, Z	1
Suh, SS	1
Hwang, J	1
Park, M	1
Seo, HH	1
Kim, HS	1
Lee, JH	1
Moh, SH	1
Lee, TK	1
Kwon, MJ	2
Lee, KY	2
Lee, HW	1
Kim, JH	1
Kim, TY	1
Tourville, TW	1
Poynter, ME	1
DeSarno, MJ	1
Struglics, A	1
Beynnon, BD	1
Viera, L	1
Bhatt, SP	1
Gautney, J	1
King, RW	1
Bailey, WC	1
Dransfield, MT	1
Ryu, J	1
Nam, TJ	1
Lee, S	1
Lee, Y	1
Kim, W	1
Nam, J	1
Jeong, S	1
Yoo, JW	1
Kim, MS	1
Moon, HR	1
Jung, Y	1
Liu, CW	1
Rice, S	1
Caldow, MK	1
Godeassi, DP	1
Jeong, EJ	1
Choi, M	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Glutathione and Fuel Oxidation in Aging[NCT01870193]	Early Phase 1	36 participants (Anticipated)	Interventional	2013-04-23	Completed
Controlled and Randomized Clinical Trial for Evaluating the Effect of a Supplement of Glycine as Adjuvant in the Treatment of COVID-19 Pneumonia in Patients Initiating Mechanical Ventilation[NCT04443673]		59 participants (Actual)	Interventional	2020-06-15	Terminated (stopped due to An interim analysis showed no difference in major outcomes (n=35 glycine and n=24 control participants))
Evaluation of the Capability of a Glycine Oral Supplement for Diminishing Bronchial Inflammation in Children With Cystic Fibrosis[NCT01417481]	Phase 2	13 participants (Actual)	Interventional	2012-03-31	Terminated (stopped due to Some of the researchers finished their participation in the study.)
Erythritol Powder Air Polishing as an Adjunct in Non-surgical Periodontal Therapy in the Management of Periodontitis: a Randomised Clinical Trial[NCT04178291]		24 participants (Anticipated)	Interventional	2020-01-31	Recruiting
Erythritol Air-polishing Versus Curette/Ultrasonic Debridement of Mandibular Furcation Lesions in Supportive Periodontal Therapy A 12-Month Randomized Controlled Trial[NCT04493398]		20 participants (Actual)	Interventional	2015-06-01	Completed
A Pilot Study of Perioperative Application of Sivelestat Sodium in Acute Type A Aortic Dissection Patients With Preoperative Moderate to Severe Hypoxemia to Shorten the Duration of Postoperative Invasive Mechanical Ventilation[NCT05874700]		30 participants (Anticipated)	Interventional	2023-05-31	Not yet recruiting
A Multicentre 3 Year Longitudinal Prospective Study to Identify Novel Endpoints and Compare These With Forced Expiratory Volume in 1 Second (FEV1) for Their Ability to Measure and Predict COPD Severity and Its Progression Over Time[NCT00292552]		2,747 participants (Actual)	Observational	2005-12-31	Completed
Hypertension in High School Students: Genetic and Environmental Factors[NCT06049641]		2,638 participants (Actual)	Observational	2014-10-31	Completed
A Placebo-controlled Trial of Roflumilast (Daliresp) on Markers of Inflammation in Chronic Obstructive Pulmonary Disease (COPD)[NCT01572948]		27 participants (Actual)	Interventional	2012-06-30	Completed
The Effects of Glycine on Atherosclerosis and Metabolic Syndrome-related Parameters: A Clinical and Ex-vivo Study.[NCT03850314]	Phase 2/Phase 3	50 participants (Anticipated)	Interventional	2019-03-31	Not yet recruiting
The Effect of Pre- and Postoperative Supplemental Enteral Nutrition in High-Risk Patients Undergoing Elective Cardiac Surgery. A Prospective Double Blind Study.[NCT00247793]		0 participants	Interventional	1996-07-31	Completed
A Phase II Double Blind Randomized Controlled Trial of High Dose Vitamin B12 in Septic Shock[NCT03783091]	Phase 2	20 participants (Anticipated)	Interventional	2019-08-05	Recruiting
Hydrogen Sulfide as Prognostic Factor[NCT01088490]		50 participants (Actual)	Observational	2010-01-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

To correct for the baseline variability, all measurements were expressed as percentage of baseline (value at week 8 with respect to baseline value [beginning of the glycine or placebo period, respectively]). Then, percentages were log-transformed to adjust to a normal distribution. (NCT01417481)
Timeframe: 8 weeks

Changes in Sputum Concentration of Inflammatory Biomarkers (G-CSF)

Intervention	log (percent change) (Mean)
Glycine	-0.3908
Placebo	0.2035

To correct for the baseline variability, all measurements were expressed as percentage of baseline (value at week 8 with respect to baseline value [beginning of the glycine or placebo period, respectively]). Then, percentage change was log-transformed to adjust to a normal distribution. (NCT01417481)
Timeframe: 8 weeks

Changes in Sputum Concentration of Inflammatory Biomarkers (IL-6)

Intervention	log (percent change) (Mean)
Glycine	-0.0819
Placebo	0.1668

To correct for the baseline variability, all measurements were expressed as percentage of baseline (value at week 8 with respect to baseline value [beginning of the glycine or placebo period, respectively]). Then, percentage change was log-transformed to adjust to a normal distribution. (NCT01417481)
Timeframe: 8 weeks

Changes in Clinical Data Scores (Other Than Sputum Production, Dyspnea and Global Symptoms)

Intervention	log (percent change) (Mean)
Glycine	-0.00007
Placebo	0.1739

"To correct for the baseline variability, all measurements were expressed as percentage of baseline (value at week 8 with respect to baseline value [beginning of the glycine or placebo period, respectively]).~Each respiratory symptom (Cough severity, Sputum features, Appetite, Dyspnea, and Energy perception) was evaluated in a 5-options Likert scale, ranging from 1 (better) to 5 (worse). The total score was computed by the simple sum of the five symptoms." (NCT01417481)
Timeframe: 8 weeks

Changes in FEV1, FEF25, and FEFmax

Intervention	Percentage of baseline (Mean)
	Cough questionnaire score	Appetite questionnaire score	Energy questionnaire score	Body weight	Height	Heart rate	Respiratory rate	Temperature
Glycine	81.1	89.1	84.6	101.6	100.5	103.5	94.8	100.0
Placebo	89.1	132.1	111.5	103.6	100.5	98.1	109.0	100.1

Changes in Other Spirometric Variables

Intervention	Percentage of baseline (Mean)
	Forced expiratory volume at first second (FEV1)	Forced expiratory flow at 25%FVC (FEF25)	Maximal forced expiratory flow (FEFmax, PEFR)
Glycine	109.7	133.9	115.3
Placebo	91.4	83.3	91.2

Changes in Pulse Oximetry, FEV1/FVC, and FEF50.

Intervention	Percentage of baseline (Mean)
	Forced vital capacity (FVC)	Forced expiratory flow at 75%FVC (FEF75)
Glycine	104.1	111.8
Placebo	100.6	108.9

Changes in Score for Sputum Production, Dyspnea and Global Symptoms

Intervention	Percentage of baseline (Mean)
	Peripheral oxygen saturation (SpO2)	FEV1/FVC	Forced expiratory flow at 50%FVC (FEF50)
Glycine	105.2	105.2	115.5
Placebo	98.9	94.9	93.1

"To correct for the baseline variability, all measurements were expressed as percentage of baseline (value at week 8 with respect to baseline value [beginning of the glycine or placebo period, respectively]).~In the symptoms questionnaire, each respiratory symptom (Cough severity, Sputum features, Appetite, Dyspnea, and Energy perception) was evaluated in a 5-options Likert scale, ranging from 1 (better) to 5 (worse). The total score was computed by the simple sum of the five symptoms." (NCT01417481)
Timeframe: 8 weeks

Changes in Serum Concentration of Inflammatory Biomarkers (Other Than TNF-alpha)

Intervention	Percentage of baseline (Mean)
	Sputum questionnaire score	Dyspnea questionnaire score	Total questionnaire score
Glycine	82.0	75.6	77.7
Placebo	102.6	103.8	98.7

Changes in Sputum Concentration of Inflammatory Biomarkers (Other Than IL-6 and G-CSF)

Intervention	log (percent change) (Mean)
	Myeloperoxidase	IL-1	IL-4	IL-6	IL-7	IL-8	IL-12	IL-13	G-CSF	IFN-gamma	MCP-1	MIP-1beta
Glycine	-0.4361	-0.1635	0.2964	0.0085	0.0356	-0.1466	0.3203	-0.0561	-0.0776	0.3272	-0.0836	0.0330
Placebo	-0.2906	-0.0352	0.1470	0.2255	0.0819	-0.2364	0.2603	0.1953	0.2272	0.3639	0.0472	-0.0608

To correct for the baseline variability, all measurements were expressed as percentage of baseline (value at week 8 with respect to baseline value [beginning of the glycine or placebo period, respectively]). Then, percentage change was log-transformed to adjust to a normal distribution. (NCT01417481)
Timeframe: 8 weeks

Intervention	log (percent change) (Mean)
	Myeloperoxidase	IL-1	IL-2	IL-4	IL-5	IL-7	IL-8	IL-10	IL-12	IL-13	IL-17	IFN-gamma	MCP-1	MIP-1beta	TNF-alpha	GM-CSF
Glycine	0.1294	-0.0918	0.0233	-0.0161	0.2498	0.0611	-0.0824	0.0549	0.1675	0.1630	0.0680	0.0248	0.0042	-0.0303	0.0412	-0.0538
Placebo	0.0669	-0.0102	-0.0274	0.0522	0.1304	0.1387	0.0542	0.0074	0.0677	0.0953	0.1140	0.0649	0.2608	0.0977	0.1568	-0.0822

Article	Year
Pleiotropic Outcomes of Glyphosate Exposure: From Organ Damage to Effects on Inflammation, Cancer, Reproduction and Development. International journal of molecular sciences, 2021, Nov-22, Volume: 22, Issue:22 Topics: DNA Damage; Europe; Gene Expression Regulation; Glycine; Glyphosate; Herbicides; Humans; Inflammatio	2021
Glycine: The Smallest Anti-Inflammatory Micronutrient. International journal of molecular sciences, 2023, Jul-08, Volume: 24, Issue:14 Topics: Amino Acids; Anti-Inflammatory Agents; Cytokines; Glycine; Humans; Inflammation; Micronutrients; NF-	2023
Targeting Hypoxia-Inducible Factors for the Treatment of Anemia in Chronic Kidney Disease Patients. American journal of nephrology, 2017, Volume: 45, Issue:3 Topics: Anemia; Animals; Barbiturates; Blood Pressure; Disease Models, Animal; Drug Design; Drug Interaction	2017
The human tri-peptide GHK and tissue remodeling. Journal of biomaterials science. Polymer edition, 2008, Volume: 19, Issue:8 Topics: Albumins; Animals; Anti-Inflammatory Agents; Binding Sites; Copper; Fibroblasts; Glycine; Histidine;	2008
Cannabinoids, endocannabinoids, and related analogs in inflammation. The AAPS journal, 2009, Volume: 11, Issue:1 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acids; Cannabinoid Receptor Modulators	2009
Glycine, a simple physiological compound protecting by yet puzzling mechanism(s) against ischaemia-reperfusion injury: current knowledge. British journal of pharmacology, 2012, Volume: 165, Issue:7 Topics: Animals; Cell Membrane; Cells, Cultured; Glycine; Humans; In Vitro Techniques; Inflammation; Intesti	2012
Glycine, a simple physiological compound protecting by yet puzzling mechanism(s) against ischaemia-reperfusion injury: current knowledge. British journal of pharmacology, 2012, Volume: 165, Issue:7 Topics: Animals; Cell Membrane; Cells, Cultured; Glycine; Humans; In Vitro Techniques; Inflammation; Intesti	2012
Glycine, a simple physiological compound protecting by yet puzzling mechanism(s) against ischaemia-reperfusion injury: current knowledge. British journal of pharmacology, 2012, Volume: 165, Issue:7 Topics: Animals; Cell Membrane; Cells, Cultured; Glycine; Humans; In Vitro Techniques; Inflammation; Intesti	2012
Glycine, a simple physiological compound protecting by yet puzzling mechanism(s) against ischaemia-reperfusion injury: current knowledge. British journal of pharmacology, 2012, Volume: 165, Issue:7 Topics: Animals; Cell Membrane; Cells, Cultured; Glycine; Humans; In Vitro Techniques; Inflammation; Intesti	2012
L-Glycine: a novel antiinflammatory, immunomodulatory, and cytoprotective agent. Current opinion in clinical nutrition and metabolic care, 2003, Volume: 6, Issue:2 Topics: Adjuvants, Immunologic; Anti-Inflammatory Agents; Calcium Channels; Chloride Channels; Cytoprotectio	2003
L-Glycine: a novel antiinflammatory, immunomodulatory, and cytoprotective agent. Current opinion in clinical nutrition and metabolic care, 2003, Volume: 6, Issue:2 Topics: Adjuvants, Immunologic; Anti-Inflammatory Agents; Calcium Channels; Chloride Channels; Cytoprotectio	2003
L-Glycine: a novel antiinflammatory, immunomodulatory, and cytoprotective agent. Current opinion in clinical nutrition and metabolic care, 2003, Volume: 6, Issue:2 Topics: Adjuvants, Immunologic; Anti-Inflammatory Agents; Calcium Channels; Chloride Channels; Cytoprotectio	2003
L-Glycine: a novel antiinflammatory, immunomodulatory, and cytoprotective agent. Current opinion in clinical nutrition and metabolic care, 2003, Volume: 6, Issue:2 Topics: Adjuvants, Immunologic; Anti-Inflammatory Agents; Calcium Channels; Chloride Channels; Cytoprotectio	2003
Loss of glycinergic and GABAergic inhibition in chronic pain--contributions of inflammation and microglia. International immunopharmacology, 2008, Volume: 8, Issue:2 Topics: Animals; Chronic Disease; Dinoprostone; gamma-Aminobutyric Acid; Glycine; Humans; Inflammation; Micr	2008
Glycine: a new anti-inflammatory immunonutrient. Cellular and molecular life sciences : CMLS, 1999, Nov-30, Volume: 56, Issue:9-10 Topics: Alcohols; Animals; Anti-Inflammatory Agents; Calcium Channels, L-Type; Chloride Channels; Cyclospori	1999

Article	Year
NMR based metabolic profiling of patients with potential celiac disease elucidating early biochemical changes of gluten-sensitivity: A pilot study. Clinica chimica acta; international journal of clinical chemistry, 2022, Jun-01, Volume: 531 Topics: Arginine; Celiac Disease; Glutens; Glycine; Histidine; Humans; Inflammation; Magnetic Resonance Spec	2022
Exposure to glyphosate-based herbicide during early stages of development increases insulin sensitivity and causes liver inflammation in adult mice offspring. Einstein (Sao Paulo, Brazil), 2022, Volume: 20 Topics: Animals; Female; Glucose; Glycine; Glyphosate; Herbicides; Humans; Inflammation; Insulin; Insulin Re	2022
Dichloroacetate improves systemic energy balance and feeding behavior during sepsis. JCI insight, 2022, 06-22, Volume: 7, Issue:12 Topics: Acetates; Animals; Energy Metabolism; Feeding Behavior; Glycine; Inflammation; Mice; Sepsis	2022
Effects of exposure to glyphosate on oxidative stress, inflammation, and lung function in maize farmers, Northern Thailand. BMC public health, 2022, 07-14, Volume: 22, Issue:1 Topics: Farmers; Glycine; Glyphosate; Herbicides; Humans; Inflammation; Lung; Oxidative Stress; Thailand; Ze	2022
d-Proline Reductase Underlies Proline-Dependent Growth of Clostridioides difficile. Journal of bacteriology, 2022, 08-16, Volume: 204, Issue:8 Topics: Amino Acid Oxidoreductases; Amino Acids; Clostridioides; Clostridioides difficile; Glycine; Humans;	2022
Colitis-associated intestinal microbiota regulates brain glycine and host behavior in mice. Scientific reports, 2022, 09-29, Volume: 12, Issue:1 Topics: Animals; Brain; Choline; Colitis; Fabaceae; Female; Gastrointestinal Microbiome; Glycine; Inflammati	2022
Extracellular serine empowers epidermal proliferation and psoriasis-like symptoms. Science advances, 2022, 12-16, Volume: 8, Issue:50 Topics: Animals; Cell Proliferation; Glycine; Glycine Hydroxymethyltransferase; Humans; Inflammation; Mice;	2022
Extracellular serine empowers epidermal proliferation and psoriasis-like symptoms. Science advances, 2022, 12-16, Volume: 8, Issue:50 Topics: Animals; Cell Proliferation; Glycine; Glycine Hydroxymethyltransferase; Humans; Inflammation; Mice;	2022
Extracellular serine empowers epidermal proliferation and psoriasis-like symptoms. Science advances, 2022, 12-16, Volume: 8, Issue:50 Topics: Animals; Cell Proliferation; Glycine; Glycine Hydroxymethyltransferase; Humans; Inflammation; Mice;	2022
Extracellular serine empowers epidermal proliferation and psoriasis-like symptoms. Science advances, 2022, 12-16, Volume: 8, Issue:50 Topics: Animals; Cell Proliferation; Glycine; Glycine Hydroxymethyltransferase; Humans; Inflammation; Mice;	2022
AAV-glycine receptor α3 alleviates CFA-induced inflammatory pain by downregulating ERK phosphorylation and proinflammatory cytokine expression in SD rats. Molecular medicine (Cambridge, Mass.), 2023, 02-15, Volume: 29, Issue:1 Topics: Animals; Dinoprostone; Extracellular Signal-Regulated MAP Kinases; Freund's Adjuvant; Glycine; Human	2023
Chlorogenic Acid Ameliorates Post-Infectious Irritable Bowel Syndrome by Regulating Extracellular Vesicles of Gut Microbes. Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2023, Volume: 10, Issue:28 Topics: Animals; Chlorogenic Acid; Gastrointestinal Microbiome; Glycine; Inflammation; Irritable Bowel Syndr	2023
The Protective Effect of Mycosporine-Like Amino Acids (MAAs) from Marine drugs, 2019, Aug-14, Volume: 17, Issue:8 Topics: Amino Acids; Animals; Antioxidants; Cyclohexanones; Cyclohexylamines; Cytokines; Glycine; Inflammati	2019
The Hepatoprotective Effects of Zinc Glycine on Liver Injury in Meat Duck Through Alleviating Hepatic Lipid Deposition and Inflammation. Biological trace element research, 2020, Volume: 195, Issue:2 Topics: Animals; Dietary Supplements; Ducks; Glycine; Inflammation; Lipid Metabolism; Liver; Male; Protectiv	2020
Propargylglycine decreases neuro-immune interaction inducing pain response in temporomandibular joint inflammation model. Nitric oxide : biology and chemistry, 2019, 12-01, Volume: 93 Topics: Alkynes; Animals; Cystathionine gamma-Lyase; Enzyme Inhibitors; Glycine; Hydrogen Sulfide; Hyperalge	2019
Combination of sivelestat and N-acetylcysteine alleviates the inflammatory response and exceeds standard treatment for acetaminophen-induced liver injury. Journal of leukocyte biology, 2020, Volume: 107, Issue:2 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver In	2020
Glycine Attenuates LPS-Induced Apoptosis and Inflammatory Cell Infiltration in Mouse Liver. The Journal of nutrition, 2020, 05-01, Volume: 150, Issue:5 Topics: Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Chemical and Drug Induced Liv	2020
The APOA1bp-SREBF-NOTCH axis is associated with reduced atherosclerosis risk in morbidly obese patients. Clinical nutrition (Edinburgh, Scotland), 2020, Volume: 39, Issue:11 Topics: Adult; Asparagine; Atherosclerosis; Biopsy; Carotid Intima-Media Thickness; Cross-Sectional Studies;	2020
Use of STAT6 Phosphorylation Inhibitor and Trimethylglycine as New Adjuvant Therapies for 5-Fluorouracil in Colitis-Associated Tumorigenesis. International journal of molecular sciences, 2020, Mar-20, Volume: 21, Issue:6 Topics: Adjuvants, Pharmaceutic; Animals; Apoptosis; beta Catenin; Cadherins; Carcinogenesis; Cell Adhesion	2020
Glycine Improves Ischemic Stroke Through miR-19a-3p/AMPK/GSK-3β/HO-1 Pathway. Drug design, development and therapy, 2020, Volume: 14 Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Glucose; Glucose Metabolism Disorders; Glycine; G	2020
Effects of chronic glyphosate exposure on antioxdative status, metabolism and immune response in tilapia (GIFT, Oreochromis niloticus). Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 2021, Volume: 239 Topics: Animals; Antioxidants; Biomarkers; Cichlids; Fish Proteins; Glycine; Glyphosate; Herbicides; Immunit	2021
Distinct lipid signatures are identified in the plasma of rats with chronic inflammation induced by estradiol benzoate and sex hormones. Metabolomics : Official journal of the Metabolomic Society, 2020, 09-07, Volume: 16, Issue:9 Topics: Amino Acids; Animals; Biomarkers; Carnitine; Estradiol; Glycerophospholipids; Glycine; Gonadal Stero	2020
Glycine and N-acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, genotoxicity, muscle strength, and cognition: Re Clinical and translational medicine, 2021, Volume: 11, Issue:3 Topics: Acetylcysteine; Adult; Age Factors; Aged; Aged, 80 and over; Aging; Cognition; Dietary Supplements;	2021
Pulmonary inflammatory response from co-exposure to LPS and glyphosate. Environmental toxicology and pharmacology, 2021, Volume: 86 Topics: Animals; Bronchoalveolar Lavage Fluid; Cytokines; Drug Interactions; Glycine; Glyphosate; Herbicides	2021
Dietary Supplementation with Glycine Enhances Intestinal Mucosal Integrity and Ameliorates Inflammation in C57BL/6J Mice with High-Fat Diet-Induced Obesity. The Journal of nutrition, 2021, 07-01, Volume: 151, Issue:7 Topics: Animals; Diet, High-Fat; Dietary Supplements; Gastrointestinal Microbiome; Glycine; Inflammation; Ma	2021
AJOG global reports, 2021, Volume: 1, Issue:1 Topics: Animals; Apoptosis; Breast Neoplasms; Cell Death; Cell Line, Tumor; Cell Survival; Fatty Acids; Fema	2021
Urinary metabolic insights into host-gut microbial interactions in healthy and IBD children. World journal of gastroenterology, 2017, May-28, Volume: 23, Issue:20 Topics: Adolescent; Anthropometry; Bile Acids and Salts; Body Composition; Case-Control Studies; Child; Coli	2017
Mitochondria protection as a mechanism underlying the hepatoprotective effects of glycine in cholestatic mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 97 Topics: Animals; Antioxidants; Bile Acids and Salts; Biomarkers; Cholestasis; Collagen; Disease Models, Anim	2018
InVitro, Ex Vivo, and In Vivo Evaluation of a Dual pH/Redox Responsive Nanoliposomal Sludge for Transdermal Drug Delivery. Journal of pharmaceutical sciences, 2018, Volume: 107, Issue:4 Topics: Administration, Cutaneous; Animals; Chemistry, Pharmaceutical; Copper; Drug Delivery Systems; Glycin	2018
Improved Cardiovascular Function in Old Mice After N-Acetyl Cysteine and Glycine Supplemented Diet: Inflammation and Mitochondrial Factors. The journals of gerontology. Series A, Biological sciences and medical sciences, 2018, 08-10, Volume: 73, Issue:9 Topics: Acetylcysteine; Aging; Animals; Antioxidants; Cardiovascular Physiological Phenomena; Cellular Senes	2018
Pharmacological activation of REV-ERBα represses LPS-induced microglial activation through the NF-κB pathway. Acta pharmacologica Sinica, 2019, Volume: 40, Issue:1 Topics: Animals; Cell Line, Tumor; Glycine; HEK293 Cells; Humans; Inflammation; Male; Mesencephalon; Mice, I	2019
Enhanced pause correlates with airway neutrophils and airway-epithelial injury in asthmatic mice treated with dexamethasone. The Journal of asthma : official journal of the Association for the Care of Asthma, 2019, Volume: 56, Issue:1 Topics: Animals; Anti-Inflammatory Agents; Asthma; Bronchoalveolar Lavage Fluid; Dexamethasone; Disease Mode	2019
Glycine Relieves Intestinal Injury by Maintaining mTOR Signaling and Suppressing AMPK, TLR4, and NOD Signaling in Weaned Piglets after Lipopolysaccharide Challenge. International journal of molecular sciences, 2018, Jul-06, Volume: 19, Issue:7 Topics: AMP-Activated Protein Kinase Kinases; Animals; Escherichia coli; Glycine; Ileum; Inflammation; Injec	2018
ONO-5046 suppresses reactive oxidative species-associated formation of neutrophil extracellular traps. Life sciences, 2018, Oct-01, Volume: 210 Topics: Adult; Cells, Cultured; Extracellular Traps; Glycine; Humans; Inflammation; Lipopolysaccharides; Neu	2018
Mycosporine-2-glycine exerts anti-inflammatory and antioxidant effects in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. Archives of biochemistry and biophysics, 2019, 02-15, Volume: 662 Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Cell Survival; Cyclohexanols; Glycine; Inflammation	2019
Stimulation of nuclear receptor REV-ERBs suppresses production of pronociceptive molecules in cultured spinal astrocytes and ameliorates mechanical hypersensitivity of inflammatory and neuropathic pain of mice. Brain, behavior, and immunity, 2019, Volume: 78 Topics: Animals; Astrocytes; Cytokines; Female; Glial Fibrillary Acidic Protein; Glycine; Hyperalgesia; Infl	2019
LPS-induced Apoptosis is Partially Mediated by Hydrogen Sulphide in RAW 264.7 Murine Macrophages. Immunological investigations, 2019, Volume: 48, Issue:5 Topics: Alkynes; Animals; Antibodies, Blocking; Apoptosis; bcl-2-Associated X Protein; Cystathionine gamma-L	2019
Hydrogen sulfide impacts on inflammation-induced adipocyte dysfunction. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2019, Volume: 131 Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; Alkynes; Animals; Cell Differentiation; Gene Expression; Gly	2019
Maternal glyphosate-based herbicide exposure alters antioxidant-related genes in the brain and serum metabolites of male rat offspring. Neurotoxicology, 2019, Volume: 74 Topics: Animals; Antioxidants; Brain Chemistry; Female; Gene Expression Regulation; Gene Regulatory Networks	2019
Contribution of skeletal muscular glycine to rapid antidepressant effects of ketamine in an inflammation-induced mouse model of depression. Psychopharmacology, 2019, Volume: 236, Issue:12 Topics: Animals; Antidepressive Agents; Depression; Disease Models, Animal; Glycine; Inflammation; Ketamine;	2019
Sivelestat sodium hydrate reduces radiation-induced lung injury in mice by inhibiting neutrophil elastase. Molecular medicine reports, 2013, Volume: 7, Issue:4 Topics: Abnormalities, Radiation-Induced; Animals; Glycine; Humans; Inflammation; Leukocyte Elastase; Lung;	2013
Anti-inflammatory properties of a dual PPARgamma/alpha agonist muraglitazar in in vitro and in vivo models. Arthritis research & therapy, 2013, Apr-17, Volume: 15, Issue:2 Topics: Animals; Anti-Inflammatory Agents; Blotting, Western; Enzyme-Linked Immunosorbent Assay; Gene Expres	2013
Collagen hydrolysate inhibits zymosan-induced inflammation. Experimental biology and medicine (Maywood, N.J.), 2013, Volume: 238, Issue:7 Topics: Animals; Chromatography, High Pressure Liquid; Collagen; Ear; Glycine; Hydrolysis; Inflammation; Int	2013
Protective effects of sivelestat in a caerulein-induced rat acute pancreatitis model. Inflammation, 2013, Volume: 36, Issue:6 Topics: Amylases; Animals; Antioxidants; Ceruletide; Corticosterone; Disease Models, Animal; Glycine; Inflam	2013
Glycine administration attenuates skeletal muscle wasting in a mouse model of cancer cachexia. Clinical nutrition (Edinburgh, Scotland), 2014, Volume: 33, Issue:3 Topics: Adipose Tissue; Animals; Body Mass Index; Cachexia; Cell Line, Tumor; Disease Models, Animal; Fatty	2014
Beneficial effects of cod protein on inflammatory cell accumulation in rat skeletal muscle after injury are driven by its high levels of arginine, glycine, taurine and lysine. PloS one, 2013, Volume: 8, Issue:10 Topics: Amino Acids; Animals; Arginine; Cyclooxygenase 2; Dietary Proteins; Eating; Fish Proteins; Gadiforme	2013
Carrier-linked mutual prodrugs of biphenylacetic acid as a promising alternative to bioprecursor fenbufen: design, kinetics, and pharmacological studies. Inflammopharmacology, 2014, Volume: 22, Issue:4 Topics: Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Exper	2014
A circadian clock gene, Rev-erbα, modulates the inflammatory function of macrophages through the negative regulation of Ccl2 expression. Journal of immunology (Baltimore, Md. : 1950), 2014, Jan-01, Volume: 192, Issue:1 Topics: Age Factors; Animals; Cell Adhesion; Cell Line; Cell Movement; Chemokine CCL2; Circadian Clocks; Gen	2014
Glycoprotein 130 polymorphism predicts soluble glycoprotein 130 levels. Metabolism: clinical and experimental, 2014, Volume: 63, Issue:5 Topics: Aged; Amino Acid Substitution; Cohort Studies; Cysteine; Cytokine Receptor gp130; Gene Frequency; Gl	2014
Effect of additional preoperative administration of the neutrophil elastase inhibitor sivelestat on perioperative inflammatory response after pediatric heart surgery with cardiopulmonary bypass. Artificial organs, 2014, Volume: 38, Issue:12 Topics: C-Reactive Protein; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Female; Glycine; Heart Sept	2014
Klotho gene deficiency causes salt-sensitive hypertension via monocyte chemotactic protein-1/CC chemokine receptor 2-mediated inflammation. Journal of the American Society of Nephrology : JASN, 2015, Volume: 26, Issue:1 Topics: Animals; Benzamides; Blood Pressure; Chemokine CCL2; Disease Models, Animal; Gene Expression Regulat	2015
Anti-inflammation activities of mycosporine-like amino acids (MAAs) in response to UV radiation suggest potential anti-skin aging activity. Marine drugs, 2014, Oct-14, Volume: 12, Issue:10 Topics: Amino Acids; Anti-Inflammatory Agents; Cell Line; Chlamydomonas; Chlorophyta; Cyclohexanols; Cyclohe	2014
SOD3 Variant, R213G, Altered SOD3 Function, Leading to ROS-Mediated Inflammation and Damage in Multiple Organs of Premature Aging Mice. Antioxidants & redox signaling, 2015, Oct-20, Volume: 23, Issue:12 Topics: Aging, Premature; Animal Structures; Animals; Arginine; Cell Line, Tumor; Glycine; Humans; Inflammat	2015
Relationship between synovial fluid ARGS-aggrecan fragments, cytokines, MMPs, and TIMPs following acute ACL injury: A cross-sectional study. Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2015, Volume: 33, Issue:12 Topics: Adolescent; Adult; Aggrecans; Alanine; Anterior Cruciate Ligament Injuries; Arginine; Body Mass Inde	2015
Nrf2 and NF-κB Signaling Pathways Contribute to Porphyra-334-Mediated Inhibition of UVA-Induced Inflammation in Skin Fibroblasts. Marine drugs, 2015, Jul-31, Volume: 13, Issue:8 Topics: Antioxidants; Cells, Cultured; Cyclohexanones; Fibroblasts; Glycine; Humans; Inflammation; Interleuk	2015
Evaluation of glycine-bearing celecoxib derivatives as a colon-specific mutual prodrug acting on nuclear factor-κB, an anti-inflammatory target. Drug design, development and therapy, 2015, Volume: 9 Topics: Animals; Anti-Inflammatory Agents; Celecoxib; Cell Line; Colitis; Colon; Drug Delivery Systems; Drug	2015
Increasing glutathione concentrations with cysteine and glycine supplementation lowers inflammation in HIV patients. AIDS (London, England), 2015, Sep-10, Volume: 29, Issue:14 Topics: C-Reactive Protein; Cysteine; Diet; Glutathione; Glycine; HIV Infections; Humans; Inflammation; Male	2015
Glycine supplementation during calorie restriction accelerates fat loss and protects against further muscle loss in obese mice. Clinical nutrition (Edinburgh, Scotland), 2016, Volume: 35, Issue:5 Topics: Animals; Body Composition; Body Mass Index; Caloric Restriction; Cytokines; Diet, High-Fat; Dietary	2016
The spacer arm length in cell-penetrating peptides influences chitosan/siRNA nanoparticle delivery for pulmonary inflammation treatment. Nanoscale, 2015, Dec-21, Volume: 7, Issue:47 Topics: Animals; Arginine; Cell Line, Tumor; Cell Membrane; Cell Survival; Cell-Penetrating Peptides; Chitos	2015
The investigation of anti-inflammatory activity of volatile oil of Angelica sinensis by plasma metabolomics approach. International immunopharmacology, 2015, Volume: 29, Issue:2 Topics: Angelica sinensis; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Carrageenan; Edema; Glycine;	2015
Proresolving Actions of Synthetic and Natural Protease Inhibitors Are Mediated by Annexin A1. Journal of immunology (Baltimore, Md. : 1950), 2016, Feb-15, Volume: 196, Issue:4 Topics: Animals; Annexin A1; Apoptosis; Blotting, Western; Flow Cytometry; Glycine; Humans; Inflammation; Le	2016
Cysteinyl-glycine reduces mucosal proinflammatory cytokine response to fMLP in a parenterally-fed piglet model. Pediatric research, 2016, Volume: 80, Issue:2 Topics: Animals; Cysteine; Cytokines; Dipeptides; Disease Models, Animal; Genetic Predisposition to Disease;	2016
Glycine inhibits ethanol-induced oxidative stress, neuroinflammation and apoptotic neurodegeneration in postnatal rat brain. Neurochemistry international, 2016, Volume: 96 Topics: Animals; Animals, Newborn; Apoptosis; Brain; Cell Line, Tumor; Dose-Response Relationship, Drug; Eth	2016
Enhanced Anti-Inflammatory Efficacy Through Targeting to Macrophages: Synthesis and In Vitro Evaluation of Folate-Glycine-Celecoxib. AAPS PharmSciTech, 2017, Volume: 18, Issue:3 Topics: Animals; Anti-Inflammatory Agents; Celecoxib; Cell Line; Cyclooxygenase 2 Inhibitors; Folic Acid; Gl	2017
Immunomodulatory Effects of the Mycosporine-Like Amino Acids Shinorine and Porphyra-334. Marine drugs, 2016, Jun-21, Volume: 14, Issue:6 Topics: Amino Acids; Cell Line, Tumor; Cyclohexanones; Cyclohexylamines; Glycine; Humans; Immunologic Factor	2016
Prolonged feeding with guanidinoacetate, a methyl group consumer, exacerbates ethanol-induced liver injury. World journal of gastroenterology, 2016, Oct-14, Volume: 22, Issue:38 Topics: Alanine Transaminase; Amidinotransferases; Animals; Aspartate Aminotransferases; Body Weight; Calciu	2016
Inhibition Mediated by Glycinergic and GABAergic Receptors on Excitatory Neurons in Mouse Superficial Dorsal Horn Is Location-Specific but Modified by Inflammation. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017, 03-01, Volume: 37, Issue:9 Topics: Animals; Animals, Newborn; Disease Models, Animal; Freund's Adjuvant; gamma-Aminobutyric Acid; Glyci	2017
Metabotropic glutamate receptor 5 activation inhibits microglial associated inflammation and neurotoxicity. Glia, 2009, Apr-01, Volume: 57, Issue:5 Topics: Animals; Anti-Inflammatory Agents; Calcium; Cells, Cultured; Chelating Agents; Excitatory Amino Acid	2009
Hydrogen sulphide is pro-inflammatory in haemorrhagic shock. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2008, Volume: 57, Issue:11 Topics: Alkynes; Animals; Blood Pressure; Glycine; Heart Rate; Hydrogen Sulfide; Inflammation; Interleukin-1	2008
Incorporation of 5-chlorocytosine into mammalian DNA results in heritable gene silencing and altered cytosine methylation patterns. Carcinogenesis, 2009, Volume: 30, Issue:5 Topics: Animals; CHO Cells; Cricetinae; Cricetulus; Cytosine; DNA; DNA Damage; DNA Replication; Gene Silenci	2009
Effects of dietary glycine supplementation and fish meal on inflammatory responses in broiler chicks. British poultry science, 2009, Volume: 50, Issue:4 Topics: Animals; Ceruloplasmin; Chickens; Diet; Fish Products; Glycine; Inflammation; Interleukin-1beta; Mal	2009
Antinociceptive actions of honokiol and magnolol on glutamatergic and inflammatory pain. Journal of biomedical science, 2009, Oct-16, Volume: 16 Topics: Analgesics; Animals; Anti-Infective Agents; Biphenyl Compounds; Dinoprostone; Excitatory Amino Acid	2009
Neutrophil elastase inhibitor improves survival of rats with clinically relevant sepsis. Shock (Augusta, Ga.), 2010, Volume: 33, Issue:5 Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Cecum; Disease Models, Animal; Gly	2010
Considering amyloidosis in patients with clinically unresponsive vitreous inflammation (Oculoleptomeningeal amyloidosis in 3 individuals with transthyretin variant Tyr69His. Vol. 44[3]). Canadian journal of ophthalmology. Journal canadien d'ophtalmologie, 2010, Volume: 45, Issue:1 Topics: Adrenal Cortex Hormones; Amyloid Neuropathies, Familial; Drug Resistance; Eye Diseases; Genetic Vari	2010
The protective function of neutrophil elastase inhibitor in liver ischemia/reperfusion injury. Transplantation, 2010, May-15, Volume: 89, Issue:9 Topics: Animals; Chemokine CXCL1; DNA Primers; Glycine; Humans; Immunohistochemistry; Inflammation; Interleu	2010
The inhibitory neurotransmitter glycine modulates macrophage activity by activation of neutral amino acid transporters. Journal of neuroscience research, 2010, Aug-15, Volume: 88, Issue:11 Topics: Amino Acid Transport Systems, Neutral; Animals; Biotransformation; Cell Proliferation; Cell Survival	2010
Inhibition of hydrogen sulphide formation reduces cisplatin-induced renal damage. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2011, Volume: 26, Issue:2 Topics: Alkynes; Animals; Antineoplastic Agents; Cisplatin; Disease Models, Animal; Enzyme Inhibitors; Glyci	2011
Anti-inflammatory role of glycine in reducing rodent postoperative inflammatory ileus. Neurogastroenterology and motility, 2011, Volume: 23, Issue:1 Topics: Animals; Anti-Inflammatory Agents; Glycine; Ileus; Inflammation; Male; Mice; Mice, Inbred C57BL; Pos	2011
A survey of the effects of sivelestat sodium administration on patients with postoperative respiratory dysfunction. Surgery today, 2010, Volume: 40, Issue:11 Topics: Adult; Aged; Aged, 80 and over; Female; Glycine; Health Status; Health Surveys; Humans; Inflammation	2010
Involvement of endogenous hydrogen sulfide in cigarette smoke-induced changes in airway responsiveness and inflammation of rat lung. Cytokine, 2011, Volume: 53, Issue:3 Topics: Acetylcholine; Alkynes; Animals; Cystathionine gamma-Lyase; Dose-Response Relationship, Drug; Enzyme	2011
Metabotropic glutamate receptor subtype 8 in the amygdala modulates thermal threshold, neurotransmitter release, and rostral ventromedial medulla cell activity in inflammatory pain. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011, Mar-23, Volume: 31, Issue:12 Topics: Amino Acids; Amygdala; Animals; Behavior, Animal; Benzoates; Blotting, Western; Carrageenan; Chromat	2011
Split-liver procedure and inflammatory response: improvement by pharmacological preconditioning. The Journal of surgical research, 2011, Jun-01, Volume: 168, Issue:1 Topics: Animals; Apoptosis; Cell Movement; Cytokines; Deferoxamine; Drug Therapy, Combination; Female; Glyci	2011
The G82S polymorphism promotes glycosylation of the receptor for advanced glycation end products (RAGE) at asparagine 81: comparison of wild-type rage with the G82S polymorphic variant. The Journal of biological chemistry, 2011, Jun-17, Volume: 286, Issue:24 Topics: Asparagine; Cell Line; Cell Membrane; Gene Expression Regulation; Glycine; Glycosylation; Humans; In	2011
Role of endogenous hydrogen sulfide on renal damage induced by adriamycin injection. Archives of toxicology, 2011, Volume: 85, Issue:12 Topics: Alkynes; Animals; Antibiotics, Antineoplastic; Doxorubicin; Glutathione; Glycine; Hydrogen Sulfide;	2011
Resolution of inflammation by N-arachidonoylglycine. Journal of cellular biochemistry, 2011, Volume: 112, Issue:11 Topics: Animals; Base Sequence; Cell Line; Cells, Cultured; DNA Primers; Glycine; Humans; Inflammation; Mice	2011
Spinal glycinergic and GABAergic neurons expressing C-fos after capsaicin stimulation are increased in rats with contralateral neuropathic pain. Neuroscience, 2011, Nov-24, Volume: 196 Topics: Animals; Capsaicin; Freund's Adjuvant; Functional Laterality; GABAergic Neurons; Glycine; Inflammati	2011
[Study of the Toll-like receptor 4 gene polymorphisms in diseases presenting with subclinical and chronic inflammation]. Orvosi hetilap, 2011, Nov-13, Volume: 152, Issue:46 Topics: Alleles; Aspartic Acid; Brain Ischemia; Chronic Disease; Cytokines; Diabetes Complications; Diabetic	2011
The effects of the early administration of sivelestat sodium, a selective neutrophil elastase inhibitor, on the postoperative course after radical surgery for esophageal cancer. Surgery today, 2012, Volume: 42, Issue:7 Topics: Acute Lung Injury; Aged; C-Reactive Protein; Esophageal Neoplasms; Esophagectomy; Female; Glycine; H	2012
Impaired glycinergic synaptic transmission and enhanced inflammatory pain in mice with reduced expression of vesicular GABA transporter (VGAT). Molecular pharmacology, 2012, Volume: 81, Issue:4 Topics: Animals; Behavior, Animal; Blotting, Western; Down-Regulation; Glycine; Inflammation; Mice; Mice, Kn	2012
A neutrophil elastase inhibitor prevents bleomycin-induced pulmonary fibrosis in mice. The European respiratory journal, 2012, Volume: 40, Issue:6 Topics: Animals; Bleomycin; Bronchoalveolar Lavage; Collagen; Fibrosis; Glycine; Inflammation; Leukocyte Ela	2012
Inhibition of cystathionine gamma-lyase and the biosynthesis of endogenous hydrogen sulphide ameliorates gentamicin-induced nephrotoxicity. European journal of pharmacology, 2012, Jun-15, Volume: 685, Issue:1-3 Topics: Alkynes; Animals; Anti-Bacterial Agents; Cystathionine gamma-Lyase; Female; Gentamicins; Glycine; Hy	2012
Inhibition of neutrophil elastase attenuates airway hyperresponsiveness and inflammation in a mouse model of secondary allergen challenge: neutrophil elastase inhibition attenuates allergic airway responses. Respiratory research, 2013, Jan-24, Volume: 14 Topics: Allergens; Animals; Bronchi; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cells, Culture	2013
Optimization of antibody labeling with rhenium-188 using a prelabeled MAG3 chelate. International journal of pharmaceutics, 2002, Nov-06, Volume: 248, Issue:1-2 Topics: Animals; Antibodies; Biological Availability; Chelating Agents; Glycine; Humans; Immunoglobulin G; I	2002
Antinociceptive activity of the N-methyl-D-aspartate receptor antagonist N-(2-Indanyl)-glycinamide hydrochloride (CHF3381) in experimental models of inflammatory and neuropathic pain. The Journal of pharmacology and experimental therapeutics, 2003, Volume: 306, Issue:2 Topics: Animals; Carrageenan; Cold Temperature; Diabetes Mellitus; Disease Models, Animal; Drug Tolerance; E	2003
Effect of beta-aminopropionitrile on incorporation of glycine by croton oil pouches in rats. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1957, Volume: 96, Issue:2 Topics: Abdominal Wall; Aminopropionitrile; Animals; Croton Oil; Cyanides; Fabaceae; Glycine; Inflammation;	1957
PATHOGENESIS OF ACUTE INFLAMMATION. VI. INFLUENCE OF OSMOLARITY AND CERTAIN METABOLIC ANTAGONISTS UPON PHAGOCYTOSIS AND ADHESIVENESS BY LEUCOCYTES RECOVERED FROM MAN. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1965, Volume: 119 Topics: Adhesiveness; Aminocaproates; Aminocaproic Acid; Citrulline; Dinitrophenols; Edetic Acid; Glycine; H	1965
An investigation into the wound-healing properties of essential oil of Ocimum gratissimum linn. Journal of wound care, 2003, Volume: 12, Issue:9 Topics: Administration, Cutaneous; Animals; Bacitracin; Cysteine; Disease Models, Animal; Drug Combinations;	2003
Oxidative cross-linking of tryptophan to glycine restrains matrix metalloproteinase activity: specific structural motifs control protein oxidation. The Journal of biological chemistry, 2004, Feb-20, Volume: 279, Issue:8 Topics: Amino Acid Motifs; Catalytic Domain; Chromatography, High Pressure Liquid; Cross-Linking Reagents; D	2004
Modulation of delayed-type hypersensitivity responses in hairless guinea pigs by peptides derived from enkephalin. Neuroimmunomodulation, 2004, Volume: 11, Issue:3 Topics: Amino Acid Sequence; Animals; Chemotaxis, Leukocyte; Enkephalin, Methionine; Glycine; Guinea Pigs; H	2004
Neuroscience. Locating a new step in pain's pathway. Science (New York, N.Y.), 2004, May-07, Volume: 304, Issue:5672 Topics: Animals; Dinoprostone; Glycine; Inflammation; Mice; Mice, Knockout; Neurons; Pain; Receptors, Glycin	2004
GlyR alpha3: an essential target for spinal PGE2-mediated inflammatory pain sensitization. Science (New York, N.Y.), 2004, May-07, Volume: 304, Issue:5672 Topics: Amino Acid Sequence; Animals; Cell Line; Cyclic AMP-Dependent Protein Kinases; Dinoprostone; Female;	2004
Hydrogen sulfide is a novel mediator of lipopolysaccharide-induced inflammation in the mouse. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2005, Volume: 19, Issue:9 Topics: Alkynes; Animals; Extracellular Signal-Regulated MAP Kinases; Glycine; Hydrogen Sulfide; Inflammatio	2005
Hydrogen sulfide is a novel mediator of lipopolysaccharide-induced inflammation in the mouse. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2005, Volume: 19, Issue:9 Topics: Alkynes; Animals; Extracellular Signal-Regulated MAP Kinases; Glycine; Hydrogen Sulfide; Inflammatio	2005
Hydrogen sulfide is a novel mediator of lipopolysaccharide-induced inflammation in the mouse. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2005, Volume: 19, Issue:9 Topics: Alkynes; Animals; Extracellular Signal-Regulated MAP Kinases; Glycine; Hydrogen Sulfide; Inflammatio	2005
Hydrogen sulfide is a novel mediator of lipopolysaccharide-induced inflammation in the mouse. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2005, Volume: 19, Issue:9 Topics: Alkynes; Animals; Extracellular Signal-Regulated MAP Kinases; Glycine; Hydrogen Sulfide; Inflammatio	2005
Insight into the involvement of Kupffer cell-derived mediators in the hepatoprotective effect of glycine upon inflammation: study on rat precision-cut liver slices. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2005, Volume: 54, Issue:3 Topics: Adenosine Triphosphate; Alanine Transaminase; Analysis of Variance; Animals; Aspartate Aminotransfer	2005
Protective effect of the G-765C COX-2 polymorphism on subclinical atherosclerosis and inflammatory markers in asymptomatic subjects with cardiovascular risk factors. Clinica chimica acta; international journal of clinical chemistry, 2006, Volume: 368, Issue:1-2 Topics: Atherosclerosis; Biomarkers; Cholesterol; Cyclooxygenase 2; Cysteine; Female; Gene Expression Regula	2006
Topical application of a novel, hydrophilic gamma-tocopherol derivative reduces photo-inflammation in mice skin. The Journal of investigative dermatology, 2006, Volume: 126, Issue:7 Topics: Administration, Topical; alpha-Tocopherol; Animals; Antioxidants; Cyclooxygenase 2; Cyclooxygenase I	2006
Design and characterization of a noncompetitive antagonist of the transient receptor potential vanilloid subunit 1 channel with in vivo analgesic and anti-inflammatory activity. The journal of pain, 2006, Volume: 7, Issue:10 Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arginine; Capsaicin; Chlorocebus aethiops; COS Cells;	2006
Peripheral mGluR5 antagonist attenuated craniofacial muscle pain and inflammation but not mGluR1 antagonist in lightly anesthetized rats. Brain research bulletin, 2006, Oct-16, Volume: 70, Issue:4-6 Topics: Anesthetics, Local; Animals; Behavior, Animal; Benzoates; Dose-Response Relationship, Drug; Drug Int	2006
Effects of (S)-3,4-DCPG, an mGlu8 receptor agonist, on inflammatory and neuropathic pain in mice. Neuropharmacology, 2007, Volume: 52, Issue:2 Topics: Analysis of Variance; Animals; Benzhydryl Compounds; Benzoates; Carrageenan; Dinucleoside Phosphates	2007
Hydrogen sulfide acts as an inflammatory mediator in cecal ligation and puncture-induced sepsis in mice by upregulating the production of cytokines and chemokines via NF-kappaB. American journal of physiology. Lung cellular and molecular physiology, 2007, Volume: 292, Issue:4 Topics: Alkynes; Animals; Cecum; Chemokines; Cystathionine gamma-Lyase; Cytokines; Disease Models, Animal; G	2007
Chiral tetrahydroquinoline derivatives as potent anti-hyperalgesic agents in animal models of sustained inflammation and chronic neuropathic pain. Bioorganic & medicinal chemistry letters, 2007, Mar-01, Volume: 17, Issue:5 Topics: Animals; Biological Availability; Disease Models, Animal; Glycine; Hydroquinones; Hyperalgesia; Infl	2007
A novel mannose-binding lectin-associated serine protease 1/3 gene variant. Scandinavian journal of immunology, 2007, Volume: 65, Issue:5 Topics: Amino Acid Substitution; Genetic Variation; Glutamic Acid; Glycine; Humans; Inflammation; Lupus Eryt	2007
Enhanced 3,5-dihydroxyphenylglycine-induced sustained nociceptive behaviors in rats with neuropathy or chronic inflammation. Behavioural brain research, 2007, Dec-03, Volume: 184, Issue:2 Topics: Analysis of Variance; Animals; Behavior, Animal; Disease Models, Animal; Excitatory Amino Acid Agoni	2007
Actions of N-arachidonyl-glycine in a rat inflammatory pain model. Molecular pain, 2007, Aug-30, Volume: 3 Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Agonists; Disease Models, Animal; Glycine; Inflamma	2007
Anti-inflammatory effects of orally ingested lactoferrin and glycine in different zymosan-induced inflammation models: evidence for synergistic activity. International immunopharmacology, 2007, Dec-15, Volume: 7, Issue:13 Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Drug Synergism; Gly	2007
A nociceptive-intensity-dependent role for hydrogen sulphide in the formalin model of persistent inflammatory pain. Neuroscience, 2008, Mar-03, Volume: 152, Issue:1 Topics: Alkynes; Animals; Enzyme Inhibitors; Formaldehyde; Glycine; Hydrogen Sulfide; Inflammation; Irritant	2008
A 20-hydroxyeicosatetraenoic acid agonist, N-[20-hydroxyeicosa-5(Z),14(Z)-dienoyl]glycine, opposes the fall in blood pressure and vascular reactivity in endotoxin-treated rats. Shock (Augusta, Ga.), 2008, Volume: 30, Issue:3 Topics: Animals; Blood Pressure; Endotoxins; Glycine; Heart Rate; Hydroxyeicosatetraenoic Acids; Inflammatio	2008
Pro-inflammatory effects of hydrogen sulphide on substance P in caerulein-induced acute pancreatitis. Journal of cellular and molecular medicine, 2008, Volume: 12, Issue:2 Topics: Acute Disease; Alkynes; Animals; Ceruletide; Cystathionine beta-Synthase; Glycine; Hydrogen Sulfide;	2008
[Autoradiographic study of protein metabolism in the cells of loose connective tissue]. Arkhiv anatomii, gistologii i embriologii, 1966, Volume: 50, Issue:5 Topics: Animals; Autoradiography; Carbon Isotopes; Cats; Cell Division; Cell Nucleus; Connective Tissue; Con	1966
Promotion of bladder tumours by endoscopic procedures in an animal model. British journal of urology, 1984, Volume: 56, Issue:6 Topics: Animals; Catheterization; Cystoscopy; Diathermy; Female; Glycine; Inflammation; Methylnitrosourea; O	1984
[Consequences of pulpectomy followed by canal obturation on the renewal of periodontal ligament in the baboon (Papio papio)]. Comptes rendus des seances de l'Academie des sciences. Serie III, Sciences de la vie, 1982, Jun-14, Volume: 294, Issue:21 Topics: Animals; Glycine; Inflammation; Papio; Periodontal Ligament; Proteins; Pulpectomy; Root Canal Obtura	1982
Protein-deficient pigs cannot maintain reduced glutathione homeostasis when subjected to the stress of inflammation. The Journal of nutrition, 1995, Volume: 125, Issue:6 Topics: Animals; Erythrocyte Count; Erythrocytes; Female; Glutathione; Glycine; Hematocrit; Hemoglobins; Hom	1995
Effects of a partial agonist and a full antagonist acting at the glycine site of the NMDA receptor on inflammation-induced mechanical hyperalgesia in rats. British journal of pharmacology, 1996, Volume: 117, Issue:7 Topics: Animals; Binding Sites; Carrageenan; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonis	1996
Pathology of the heart after overhydration with glycine solution in the mouse. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 1996, Volume: 104, Issue:12 Topics: Animals; Glycine; Heart; Inflammation; Mannitol; Mice; Myocardium; Necrosis; Solutions; Therapeutic	1996
Inflammation alters the effects of mGlu receptor agonists on spinal nociceptive neurones. European journal of pharmacology, 1998, Apr-24, Volume: 347, Issue:2-3 Topics: Animals; Carrageenan; Cycloleucine; Excitatory Amino Acid Antagonists; Glycine; Inflammation; Male;	1998
G551D cystic fibrosis mice exhibit abnormal regulation of inflammation in lungs and macrophages. Journal of immunology (Baltimore, Md. : 1950), 2000, Apr-01, Volume: 164, Issue:7 Topics: Amino Acid Substitution; Animals; Aspartic Acid; Biomarkers; Bone Marrow Cells; Cell Movement; Cysti	2000
Initiation of rapid, P53-dependent growth arrest in cultured human skin fibroblasts by reactive chlorine species. Archives of biochemistry and biophysics, 2000, May-01, Volume: 377, Issue:1 Topics: Cell Division; Cell Survival; Cells, Cultured; Chloramines; Cyclin-Dependent Kinase Inhibitor p21; C	2000
Pulmonary toxicity of inhaled aerosolized prostacyclin therapy--an observational study. Anaesthesia and intensive care, 2000, Volume: 28, Issue:2 Topics: Administration, Inhalation; Aerosols; Animals; Bronchi; Epoprostenol; Glycine; Inflammation; Lung; N	2000
Inhibition of CD95 ligand-mediated inflammation. Transplantation proceedings, 2000, Volume: 32, Issue:7 Topics: Animals; Antineoplastic Agents; Cell Division; Diabetes Mellitus, Experimental; Fas Ligand Protein;	2000
Peripheral group I metabotropic glutamate receptors modulate nociception in mice. Nature neuroscience, 2001, Volume: 4, Issue:4 Topics: Animals; Chromones; Excitatory Amino Acid Antagonists; Glycine; Hindlimb; Hot Temperature; Immunohis	2001
Metabotropic glutamate receptor subtypes 1 and 5 are activators of extracellular signal-regulated kinase signaling required for inflammatory pain in mice. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001, Jun-01, Volume: 21, Issue:11 Topics: Alternative Splicing; Animals; Behavior, Animal; Enzyme Activation; Excitatory Amino Acid Agonists;	2001
Glycine reduces the inflammatory response and organ damage in a two-hit sepsis model in rats. Shock (Augusta, Ga.), 2001, Volume: 16, Issue:2 Topics: Amino Acids; Animals; Cytokines; Disease Models, Animal; Endotoxins; Glycine; Inflammation; Liver Fu	2001
Metabotropic glutamate 1alpha receptors on peripheral primary afferent fibers: their role in nociception. Brain research, 2001, Sep-14, Volume: 913, Issue:1 Topics: Animals; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Excita	2001
Attenuation of thermal nociception and hyperalgesia by VR1 blockers. Proceedings of the National Academy of Sciences of the United States of America, 2002, Feb-19, Volume: 99, Issue:4 Topics: Animals; Calcium; Capsaicin; Dose-Response Relationship, Drug; Electrophysiology; Glycine; Hot Tempe	2002
Inhibition of thrombin abrogates the instant blood-mediated inflammatory reaction triggered by isolated human islets: possible application of the thrombin inhibitor melagatran in clinical islet transplantation. Diabetes, 2002, Volume: 51, Issue:6 Topics: ABO Blood-Group System; Aged; Aged, 80 and over; Anticoagulants; Azetidines; Benzylamines; Blood Pla	2002
[Use of acelysin solution in the treatment of acute purulent inflammatory diseases of soft tissues]. Klinicheskaia khirurgiia, 1992, Issue:2 Topics: Adolescent; Adult; Aged; Animals; Anti-Infective Agents; Aspirin; Child; Drug Combinations; Female;	1992
Analgesic and anti-inflammatory activity of DL-2-(alkoxyphenyl)glycine octyl esters. Agents and actions, 1991, Volume: 32, Issue:1-2 Topics: Analgesia; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Edema; Female;	1991
Profile of activity of a new anti-inflammatory agent, ST 679 (MED 15). Drugs under experimental and clinical research, 1990, Volume: 16, Issue:2 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Carrageenan; Concanavalin	1990
[The exclusion of nonspecific effects in testing potential anti-inflammatory agents following intraperitoneal administration]. Die Pharmazie, 1987, Volume: 42, Issue:1 Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Drug Evaluation, Preclinical; Glycine; Inflammation;	1987
The development of screening tests for D-penicillamine-like antirheumatic activity based on in vivo interactions with copper. British journal of rheumatology, 1985, Volume: 24, Issue:2 Topics: Animals; Arthritis, Rheumatoid; Capillary Permeability; Copper; Drug Interactions; Extremities; Fema	1985
Anti-inflammatory activity of esters of phenylglycine. The Journal of pharmacy and pharmacology, 1974, Volume: 26, Issue:2 Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Dextrans; Esters; Glycine; Inflammation; Lethal Dose	1974
Amino acids and inflammation. British journal of pharmacology, 1973, Volume: 47, Issue:3 Topics: Amino Acids; Animals; Carrageenan; Cysteine; Dextrans; Dose-Response Relationship, Drug; Esters; Fre	1973
The erythrocyte plasma distribution of amino acids in health and disease. Clinica chimica acta; international journal of clinical chemistry, 1968, Volume: 20, Issue:1 Topics: Acute Disease; Adolescent; Adult; Alanine; Amino Acids; Anemia, Hemolytic; Anemia, Pernicious; Bronc	1968
Uptake of labelled amino acids into human erythrocytes in disease. Clinica chimica acta; international journal of clinical chemistry, 1968, Volume: 20, Issue:1 Topics: Acute Disease; Alanine; Amino Acids; Anemia; Bronchitis; Bronchopneumonia; Carbon Isotopes; Erythroc	1968
[Separation of low molecular weight ninhydrine positive substances in pleural punctates. Contribution to the problem of inflammation]. Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1968, Aug-01, Volume: 23, Issue:15 Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Chromatography; Chromatography, Gel; Electrophoresis;	1968

glycine and Inflammation

Research Excerpts

Research

Studies (162)

Authors

Clinical Trials (13)

Trial Overview

Trial Outcomes

Changes in Serum Concentration of Inflammatory Biomarkers (TNF-alpha)

Changes in Sputum Concentration of Inflammatory Biomarkers (G-CSF)

Changes in Sputum Concentration of Inflammatory Biomarkers (IL-6)

Changes in Clinical Data Scores (Other Than Sputum Production, Dyspnea and Global Symptoms)

Changes in FEV1, FEF25, and FEFmax

Changes in Other Spirometric Variables

Changes in Pulse Oximetry, FEV1/FVC, and FEF50.

Changes in Score for Sputum Production, Dyspnea and Global Symptoms

Changes in Serum Concentration of Inflammatory Biomarkers (Other Than TNF-alpha)

Changes in Sputum Concentration of Inflammatory Biomarkers (Other Than IL-6 and G-CSF)

Induced Sputum Neutrophil Count

Induced Sputum Neutrophil Count

Induced Sputum Neutrophil Count

Induced Sputum Proline-glycine-proline (PGP) Levels at Baseline

Mean Induced Sputum Proline-glycine-proline (PGP) Levels at 1 Month After Randomization.

Mean Induced Sputum Proline-glycine-proline (PGP) Levels at 3 Months After Randomization

Reviews

Trials

Other Studies

Article	Year
A Prospective, Self-Controlled Pilot Study of the Efficacy of Roxadustat for Erythropoietin Hyporesponsiveness in Patients Requiring Chronic Ambulatory Peritoneal Dialysis. Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation, 2022, Volume: 32, Issue:5 Topics: Anemia; C-Reactive Protein; Erythropoietin; Glycine; Hemoglobins; Humans; Inflammation; Interleukin-	2022
Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial. The journals of gerontology. Series A, Biological sciences and medical sciences, 2023, 01-26, Volume: 78, Issue:1 Topics: Acetylcysteine; Aged; Aging; Animals; Dietary Supplements; Glutathione; Glycine; Health Promotion; H	2023
Effects of Guanidinoacetic Acid Loading on Biomarkers of Cardiometabolic Risk and Inflammation. Annals of nutrition & metabolism, 2018, Volume: 72, Issue:1 Topics: Biomarkers; C-Reactive Protein; Cardiovascular Diseases; Cholesterol, HDL; Dietary Supplements; Fema	2018
Effect of oral glycine on the clinical, spirometric and inflammatory status in subjects with cystic fibrosis: a pilot randomized trial. BMC pulmonary medicine, 2017, Dec-15, Volume: 17, Issue:1 Topics: Administration, Oral; Adolescent; Anti-Inflammatory Agents; Biomarkers; Child; Cross-Over Studies; C	2017
Effect of oral glycine on the clinical, spirometric and inflammatory status in subjects with cystic fibrosis: a pilot randomized trial. BMC pulmonary medicine, 2017, Dec-15, Volume: 17, Issue:1 Topics: Administration, Oral; Adolescent; Anti-Inflammatory Agents; Biomarkers; Child; Cross-Over Studies; C	2017
Effect of oral glycine on the clinical, spirometric and inflammatory status in subjects with cystic fibrosis: a pilot randomized trial. BMC pulmonary medicine, 2017, Dec-15, Volume: 17, Issue:1 Topics: Administration, Oral; Adolescent; Anti-Inflammatory Agents; Biomarkers; Child; Cross-Over Studies; C	2017
Effect of oral glycine on the clinical, spirometric and inflammatory status in subjects with cystic fibrosis: a pilot randomized trial. BMC pulmonary medicine, 2017, Dec-15, Volume: 17, Issue:1 Topics: Administration, Oral; Adolescent; Anti-Inflammatory Agents; Biomarkers; Child; Cross-Over Studies; C	2017
Subgingival glycine powder air-polishing as an additional approach to nonsurgical periodontal therapy in subjects with untreated chronic periodontitis. Journal of periodontal research, 2018, Volume: 53, Issue:3 Topics: Adolescent; Adult; Aged; Asian People; Chronic Periodontitis; Cytokines; Dental Plaque; Dental Plaqu	2018
Subgingival glycine powder air-polishing as an additional approach to nonsurgical periodontal therapy in subjects with untreated chronic periodontitis. Journal of periodontal research, 2018, Volume: 53, Issue:3 Topics: Adolescent; Adult; Aged; Asian People; Chronic Periodontitis; Cytokines; Dental Plaque; Dental Plaqu	2018
Subgingival glycine powder air-polishing as an additional approach to nonsurgical periodontal therapy in subjects with untreated chronic periodontitis. Journal of periodontal research, 2018, Volume: 53, Issue:3 Topics: Adolescent; Adult; Aged; Asian People; Chronic Periodontitis; Cytokines; Dental Plaque; Dental Plaqu	2018
Subgingival glycine powder air-polishing as an additional approach to nonsurgical periodontal therapy in subjects with untreated chronic periodontitis. Journal of periodontal research, 2018, Volume: 53, Issue:3 Topics: Adolescent; Adult; Aged; Asian People; Chronic Periodontitis; Cytokines; Dental Plaque; Dental Plaqu	2018
Neutrophil elastase inhibitor sivelestat attenuates perioperative inflammatory response in pediatric heart surgery with cardiopulmonary bypass. International heart journal, 2013, Volume: 54, Issue:3 Topics: Cardiac Surgical Procedures; Cardiopulmonary Bypass; Double-Blind Method; Female; Glycine; Humans; I	2013
Effect of the neutrophil elastase inhibitor sivelestat on perioperative inflammatory response after pediatric heart surgery with cardiopulmonary bypass: a prospective randomized study. Artificial organs, 2013, Volume: 37, Issue:12 Topics: Age Factors; Anti-Inflammatory Agents; Blood Coagulation; Blood Loss, Surgical; Cardiac Surgical Pro	2013
An aberrant leukotriene A4 hydrolase-proline-glycine-proline pathway in the pathogenesis of chronic obstructive pulmonary disease. American journal of respiratory and critical care medicine, 2014, Jul-01, Volume: 190, Issue:1 Topics: Aged; Animals; Bronchoalveolar Lavage Fluid; Cohort Studies; Disease Models, Animal; Emphysema; Epox	2014
A Randomized, Placebo-controlled Trial of Roflumilast. Effect on Proline-Glycine-Proline and Neutrophilic Inflammation in Chronic Obstructive Pulmonary Disease. American journal of respiratory and critical care medicine, 2015, Oct-15, Volume: 192, Issue:8 Topics: Aged; Aminopyridines; Benzamides; Bronchitis, Chronic; Cyclopropanes; Double-Blind Method; Epoxide H	2015
Integration of Traditional and Metabolomics Biomarkers Identifies Prognostic Metabolites for Predicting Responsiveness to Nutritional Intervention against Oxidative Stress and Inflammation. Nutrients, 2017, Mar-04, Volume: 9, Issue:3 Topics: Adult; Biomarkers; Body Mass Index; Diet; Erythrocytes; Female; Glutathione; Glycine; Humans; Inflam	2017
Capacity of glycine to modulate early inflammatory disturbances after serious gunshot injuries in the pig. Scandinavian journal of clinical and laboratory investigation, 2007, Volume: 67, Issue:2 Topics: Acute Disease; Animals; Blood Pressure; Cytokines; Glutathione; Glycine; Glycine Agents; Heart Rate;	2007
Guanidino compounds after creatine supplementation in renal failure patients and their relation to inflammatory status. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2008, Volume: 23, Issue:4 Topics: Administration, Oral; Aged; Arginine; Biomarkers; C-Reactive Protein; Creatine; Cross-Over Studies;	2008