Page last updated: 2024-10-18

glycine and Hyperammonemia

glycine has been researched along with Hyperammonemia in 12 studies

Hyperammonemia: Elevated level of AMMONIA in the blood. It is a sign of defective CATABOLISM of AMINO ACIDS or ammonia to UREA.

Research Excerpts

ExcerptRelevanceReference
"Hyperornithinemia, hyperammonemia, and homocitrullinuria (HHH) syndrome is caused by mutations in the SLC25A15 (ORNT1) gene encoding the mitochondrial ornithine transporter, but the mechanism of pathogenesis of the encephalopathy, spastic paraparesis and hepatopathy remains undetermined."7.72Hyperornithinemia, hyperammonemia, and homocitrullinuria syndrome with evidence of mitochondrial dysfunction due to a novel SLC25A15 (ORNT1) gene mutation in a Palestinian family. ( Abu-Libdeh, B; Gutman, A; Kanazawa, N; Korman, SH; Tsujino, S, 2004)
"Hyperammonemia is a common finding in children with methylmalonic acidemia."3.83A neuronal disruption in redox homeostasis elicited by ammonia alters the glycine/glutamate (GABA) cycle and contributes to MMA-induced excitability. ( Braga, DV; da Silva, AM; da Silva, LR; da Silveira Junior, ME; de Oliveira Ferreira, AP; Della-Pace, ID; Dobrachinski, F; Fighera, MR; Furian, AF; Gabbi, P; Grisólia, AB; Marchesan, S; Oliveira, MS; Ribeiro, LR; Rodrigues, FS; Royes, LF; Soares, FA, 2016)
"Hyperornithinemia, hyperammonemia, and homocitrullinuria (HHH) syndrome is caused by mutations in the SLC25A15 (ORNT1) gene encoding the mitochondrial ornithine transporter, but the mechanism of pathogenesis of the encephalopathy, spastic paraparesis and hepatopathy remains undetermined."3.72Hyperornithinemia, hyperammonemia, and homocitrullinuria syndrome with evidence of mitochondrial dysfunction due to a novel SLC25A15 (ORNT1) gene mutation in a Palestinian family. ( Abu-Libdeh, B; Gutman, A; Kanazawa, N; Korman, SH; Tsujino, S, 2004)
"Sivelestat was given for the complication of ARDS."1.42Elevation of pivaloylcarnitine by sivelestat sodium in two children. ( Bo, R; Hasegawa, Y; Ishige, N; Kobayashi, H; Nakamura, M; Takahashi, T; Yamada, K; Yamaguchi, S, 2015)
"Glycine is an important ammoniagenic amino acid, which is increased in acute liver failure (ALF)."1.40L-Ornithine phenylacetate reduces ammonia in pigs with acute liver failure through phenylacetylglycine formation: a novel ammonia-lowering pathway. ( Fuskevåg, OM; Jalan, R; Kristiansen, RG; Mæhre, H; Revhaug, A; Rose, CF; Ytrebø, LM, 2014)
"The encephalopathy and seizures were ascribed to accumulation of toxic metabolites of glycine, especially ammonia (serum level -1261 mcmol/L)."1.37Postprostatectomy seizures: A case report. ( Bichu, P; Misra, M; Phadke, G; Sangha, H, 2011)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (8.33)18.2507
2000's4 (33.33)29.6817
2010's7 (58.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Auray-Blais, C1
Maranda, B1
Lavoie, P1
Kristiansen, RG2
Rose, CF2
Fuskevåg, OM1
Mæhre, H1
Revhaug, A1
Jalan, R1
Ytrebø, LM2
Yamada, K1
Kobayashi, H1
Bo, R1
Takahashi, T1
Hasegawa, Y1
Nakamura, M1
Ishige, N1
Yamaguchi, S1
Cabrera-Pastor, A1
Taoro-Gonzalez, L1
Felipo, V3
Royes, LF1
Gabbi, P1
Ribeiro, LR1
Della-Pace, ID1
Rodrigues, FS1
de Oliveira Ferreira, AP1
da Silveira Junior, ME1
da Silva, LR1
Grisólia, AB1
Braga, DV1
Dobrachinski, F1
da Silva, AM1
Soares, FA1
Marchesan, S1
Furian, AF1
Oliveira, MS1
Fighera, MR1
Poo, JL1
Cervera, E1
de Hoyos, A1
Gil, S1
Cadena, M1
Uribe, M1
Bichu, P1
Phadke, G1
Sangha, H1
Misra, M1
Canales, JJ1
Elayadi, A1
Errami, M1
Llansola, M1
Cauli, O2
Korman, SH1
Kanazawa, N1
Abu-Libdeh, B1
Gutman, A1
Tsujino, S1
Mlili, N1
Rodrigo, R1
Bhakta, P1
Goel, A1
Acharjee, P1
Biswas, BK1

Reviews

2 reviews available for glycine and Hyperammonemia

ArticleYear
Glycine and hyperammonemia: potential target for the treatment of hepatic encephalopathy.
    Metabolic brain disease, 2016, Volume: 31, Issue:6

    Topics: Animals; Drug Delivery Systems; Glycine; Hepatic Encephalopathy; Humans; Hyperammonemia; Ornithine;

2016
[Rationale for the use of sodium benzoate in clinical hepatology].
    Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion, 1990, Volume: 42 Suppl

    Topics: Acetates; Adult; Animals; Child; Clinical Trials as Topic; Drug Evaluation, Preclinical; Glycine; He

1990

Other Studies

10 other studies available for glycine and Hyperammonemia

ArticleYear
High-throughput tandem mass spectrometry multiplex analysis for newborn urinary screening of creatine synthesis and transport disorders, Triple H syndrome and OTC deficiency.
    Clinica chimica acta; international journal of clinical chemistry, 2014, Sep-25, Volume: 436

    Topics: Biomarkers; Creatine; Creatinine; Filtration; Glycine; Humans; Hyperammonemia; Infant, Newborn; Orni

2014
L-Ornithine phenylacetate reduces ammonia in pigs with acute liver failure through phenylacetylglycine formation: a novel ammonia-lowering pathway.
    American journal of physiology. Gastrointestinal and liver physiology, 2014, Nov-15, Volume: 307, Issue:10

    Topics: Ammonia; Animals; Biomarkers; Brain; Disease Models, Animal; Female; Glycine; Hyperammonemia; Kidney

2014
Elevation of pivaloylcarnitine by sivelestat sodium in two children.
    Molecular genetics and metabolism, 2015, Volume: 116, Issue:3

    Topics: Amino Acid Metabolism, Inborn Errors; Cardiomyopathies; Carnitine; Child, Preschool; Chromatography,

2015
Hyperammonemia alters glycinergic neurotransmission and modulation of the glutamate-nitric oxide-cGMP pathway by extracellular glycine in cerebellum in vivo.
    Journal of neurochemistry, 2016, Volume: 137, Issue:4

    Topics: Animals; Cerebellum; Cyclic GMP; Dose-Response Relationship, Drug; Extracellular Fluid; Glutamic Aci

2016
A neuronal disruption in redox homeostasis elicited by ammonia alters the glycine/glutamate (GABA) cycle and contributes to MMA-induced excitability.
    Amino acids, 2016, Volume: 48, Issue:6

    Topics: Ammonia; Animals; Cerebral Cortex; Cytokines; Electroencephalography; Glutamic Acid; Glycine; Homeos

2016
Postprostatectomy seizures: A case report.
    Hemodialysis international. International Symposium on Home Hemodialysis, 2011, Volume: 15 Suppl 1

    Topics: Aged; Glycine; Humans; Hyperammonemia; Hyponatremia; Male; Prostatectomy; Renal Dialysis; Seizures

2011
Chronic hyperammonemia alters motor and neurochemical responses to activation of group I metabotropic glutamate receptors in the nucleus accumbens in rats in vivo.
    Neurobiology of disease, 2003, Volume: 14, Issue:3

    Topics: Animals; Chromones; Chronic Disease; Dopamine; Excitatory Amino Acid Agonists; Excitatory Amino Acid

2003
Hyperornithinemia, hyperammonemia, and homocitrullinuria syndrome with evidence of mitochondrial dysfunction due to a novel SLC25A15 (ORNT1) gene mutation in a Palestinian family.
    Journal of the neurological sciences, 2004, Mar-15, Volume: 218, Issue:1-2

    Topics: Adolescent; Alanine; Amino Acid Metabolism, Inborn Errors; Amino Acid Transport Systems, Basic; Arab

2004
Hyperammonaemia alters the mechanisms by which metabotropic glutamate receptors in nucleus accumbens modulate motor function.
    Journal of neurochemistry, 2007, Volume: 103, Issue:1

    Topics: Animals; Disease Models, Animal; Excitatory Amino Acid Agonists; Glycine; Hyperammonemia; Male; Micr

2007
Propofol for the management of glycine-mediated excitatory symptoms of TURP syndrome.
    European journal of anaesthesiology, 2008, Volume: 25, Issue:5

    Topics: Aged; Akathisia, Drug-Induced; Glycine; Glycine Agents; Humans; Hyperammonemia; Hypnotics and Sedati

2008