glycine has been researched along with Hepatic Encephalopathy in 22 studies
Hepatic Encephalopathy: A syndrome characterized by central nervous system dysfunction in association with LIVER FAILURE, including portal-systemic shunts. Clinical features include lethargy and CONFUSION (frequently progressing to COMA); ASTERIXIS; NYSTAGMUS, PATHOLOGIC; brisk oculovestibular reflexes; decorticate and decerebrate posturing; MUSCLE SPASTICITY; and bilateral extensor plantar reflexes (see REFLEX, BABINSKI). ELECTROENCEPHALOGRAPHY may demonstrate triphasic waves. (From Adams et al., Principles of Neurology, 6th ed, pp1117-20; Plum & Posner, Diagnosis of Stupor and Coma, 3rd ed, p222-5)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Relative deficiencies of ornithine or arginine occur in the presence of excessive ammonia, excessive lysine, growth, pregnancy, trauma, or protein deficiency and malnutrition." | 4.77 | Conditional deficiencies of ornithine or arginine. ( Zieve, L, 1986) |
| "Hepatic encephalopathy was induced in mice via injection of azoxymethane (AOM) in the presence or absence of INCB 3284 dimesylate (INCB), a chemokine receptor 2 inhibitor, or C 021 dihydrochloride (C021), a chemokine receptor 4 inhibitor." | 3.80 | Neuronal CCL2 is upregulated during hepatic encephalopathy and contributes to microglia activation and neurological decline. ( Alpini, G; DeMorrow, S; Frampton, G; Galindo, C; McMillin, M; Standeford, H; Thompson, M; Whittington, E, 2014) |
| "The neuromodulators, adenosine, serotonin, and glycine, did not alter the course of hepatic encephalopathy (HE) that followed a portacaval shunt and hepatic artery ligation in rats." | 3.67 | Inhibitory neuromodulators do not alter the course of experimental hepatic encephalopathy. ( Lindblad, S; Rzepczynski, D; Zieve, L, 1988) |
| "Hepatic encephalopathy is associated with a regional specific decrease of GABA levels in the visual cortex, while no changes were revealed for the sensorimotor cortex." | 1.42 | Low visual cortex GABA levels in hepatic encephalopathy: links to blood ammonia, critical flicker frequency, and brain osmolytes. ( Baumgarten, TJ; Butz, M; Hoogenboom, N; Oeltzschner, G; Schnitzler, A; Wittsack, HJ, 2015) |
| "All animals were tested three times for seizure threshold, and were then decapitated and the brains removed for analysis of the amino acids." | 1.30 | Effects of ammonia on pentylenetetrazole-induced seizure threshold. ( Arikan, K; Coskun, T; Guvener, B; Oran, O, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (40.91) | 18.7374 |
| 1990's | 8 (36.36) | 18.2507 |
| 2000's | 1 (4.55) | 29.6817 |
| 2010's | 3 (13.64) | 24.3611 |
| 2020's | 1 (4.55) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, XF | 1 |
| Lu, JJ | 1 |
| Li, Y | 1 |
| Yang, XY | 1 |
| Qiang, JW | 1 |
| McMillin, M | 1 |
| Frampton, G | 1 |
| Thompson, M | 1 |
| Galindo, C | 1 |
| Standeford, H | 1 |
| Whittington, E | 1 |
| Alpini, G | 1 |
| DeMorrow, S | 1 |
| Oeltzschner, G | 1 |
| Butz, M | 1 |
| Baumgarten, TJ | 1 |
| Hoogenboom, N | 1 |
| Wittsack, HJ | 1 |
| Schnitzler, A | 1 |
| Kristiansen, RG | 1 |
| Rose, CF | 1 |
| Ytrebø, LM | 1 |
| Poo, JL | 1 |
| Cervera, E | 1 |
| de Hoyos, A | 1 |
| Gil, S | 1 |
| Cadena, M | 1 |
| Uribe, M | 1 |
| MONDEN, M | 1 |
| Canales, JJ | 1 |
| Elayadi, A | 1 |
| Errami, M | 1 |
| Llansola, M | 1 |
| Cauli, O | 1 |
| Felipo, V | 1 |
| Ochiai, Y | 1 |
| Abe, S | 1 |
| Yamada, T | 1 |
| Tada, K | 1 |
| Kosaka, F | 1 |
| Helewski, K | 1 |
| Konecki, J | 1 |
| Rypins, EB | 1 |
| Milne, N | 1 |
| Sarfeh, IJ | 1 |
| Petras, S | 1 |
| Aurengo, A | 1 |
| Le, D | 1 |
| Di Paola, M | 1 |
| Jeanguillaume, C | 1 |
| Galle, P | 1 |
| Buyck, D | 1 |
| Bonnin, F | 1 |
| Bernuau, J | 1 |
| Belghiti, J | 1 |
| Bok, B | 1 |
| Morsiani, E | 1 |
| Pazzi, P | 1 |
| Moscioni, AD | 1 |
| Rozga, J | 1 |
| Azzena, G | 1 |
| Demetriou, AA | 1 |
| Arikan, K | 1 |
| Coskun, T | 1 |
| Guvener, B | 1 |
| Oran, O | 1 |
| Bosseckert, H | 1 |
| Coraim, FI | 1 |
| Owen, A | 1 |
| Trubel, W | 1 |
| Kassal, H | 1 |
| Widhalm, K | 1 |
| Kienzl, E | 1 |
| Riederer, P | 1 |
| Brücke, T | 1 |
| Kleinberger, G | 1 |
| Jellinger, K | 1 |
| Ishikawa, A | 1 |
| Ishiyama, H | 1 |
| Enomoto, T | 1 |
| Ozaki, A | 1 |
| Fukao, K | 1 |
| Okamura, T | 1 |
| Iwasaki, Y | 1 |
| Yamamoto, H | 1 |
| Rzepczynski, D | 1 |
| Zieve, L | 2 |
| Lindblad, S | 1 |
| Buxton, BH | 1 |
| Stewart, DA | 1 |
| Murray-Lyon, IM | 1 |
| Curzon, G | 1 |
| Williams, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Role of Magnetic Resonance Imaging in Detection of Minimal Hepatic Encephalopathy[NCT04131205] | 40 participants (Anticipated) | Observational | 2019-06-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for glycine and Hepatic Encephalopathy
| Article | Year |
|---|---|
Glycine and hyperammonemia: potential target for the treatment of hepatic encephalopathy.
Topics: Animals; Drug Delivery Systems; Glycine; Hepatic Encephalopathy; Humans; Hyperammonemia; Ornithine; | 2016 |
[Rationale for the use of sodium benzoate in clinical hepatology].
Topics: Acetates; Adult; Animals; Child; Clinical Trials as Topic; Drug Evaluation, Preclinical; Glycine; He | 1990 |
[Changes in and modulation of receptor activity in hepatic encephalopathy].
Topics: Ammonia; Animals; Aspartic Acid; Binding, Competitive; Biogenic Amines; Blood-Brain Barrier; Brain; | 1985 |
Conditional deficiencies of ornithine or arginine.
Topics: Amino Acids; Amino Acids, Branched-Chain; Ammonia; Animals; Arginine; Citrulline; Female; Glycine; H | 1986 |
Too much of a good thing.
Topics: Amino Acids; Animals; Blood Pressure; Central Nervous System; Eye Diseases; Food Additives; Glutamat | 1971 |
1 trial available for glycine and Hepatic Encephalopathy
| Article | Year |
|---|---|
Analysis of nutrient hepatic blood flow after 8-mm versus 16-mm portacaval H-grafts in a prospective randomized trial.
Topics: Aniline Compounds; Follow-Up Studies; Glycine; Hemorrhage; Hepatic Encephalopathy; Humans; Imino Aci | 1995 |
16 other studies available for glycine and Hepatic Encephalopathy
| Article | Year |
|---|---|
Ferrous sulfate reverses cerebral metabolic abnormality induced by minimal hepatic encephalopathy.
Topics: Animals; Arginine; Aspartic Acid; Brain; Glutamic Acid; Glycine; Hepatic Encephalopathy; Iron; Lacti | 2023 |
Neuronal CCL2 is upregulated during hepatic encephalopathy and contributes to microglia activation and neurological decline.
Topics: Animals; Azoxymethane; Benzamides; Body Temperature; Body Weight; Carcinogens; Chemokine CCL2; Disea | 2014 |
Low visual cortex GABA levels in hepatic encephalopathy: links to blood ammonia, critical flicker frequency, and brain osmolytes.
Topics: Ammonia; Brain Chemistry; Creatine; Female; Flicker Fusion; gamma-Aminobutyric Acid; Glutamine; Glyc | 2015 |
[A STUDY OF THE FREE AMINO ACIDS IN THE SERUM OF LIVER DISEASES].
Topics: Alanine; Amino Acids; Ammonia; Animals; Arginine; Blood; Carbon Tetrachloride; Chemical and Drug Ind | 1964 |
Chronic hyperammonemia alters motor and neurochemical responses to activation of group I metabotropic glutamate receptors in the nucleus accumbens in rats in vivo.
Topics: Animals; Chromones; Chronic Disease; Dopamine; Excitatory Amino Acid Agonists; Excitatory Amino Acid | 2003 |
Guanidino compounds and hemodialysis.
Topics: Acute Kidney Injury; Blood Urea Nitrogen; Creatinine; Glycine; Guanidines; Hepatic Encephalopathy; H | 1982 |
Brain protein synthesis in rats with portacaval shunts.
Topics: Animals; Brain Chemistry; Glycine; Hepatic Encephalopathy; Kinetics; Nerve Tissue Proteins; Portacav | 1994 |
Factor analysis in successive hepatobiliary imaging of native and transplant livers.
Topics: Adolescent; Aniline Compounds; Factor Analysis, Statistical; Glycine; Graft Rejection; Hepatic Encep | 1996 |
Auxiliary liver transplantation in patients with fulminant hepatic failure: hepatobiliary scintigraphic follow-up.
Topics: Adult; Aniline Compounds; Follow-Up Studies; Glycine; Hepatic Encephalopathy; Humans; Image Processi | 1997 |
In vitro morphological and functional characterization of isolated porcine hepatocytes for extracorporeal liver support: bile acid uptake and conjugation.
Topics: Animals; Bile Acids and Salts; Cells, Cultured; Female; Glycine; Hepatic Encephalopathy; Humans; Liv | 1998 |
Effects of ammonia on pentylenetetrazole-induced seizure threshold.
Topics: Ammonia; Animals; Aspartic Acid; Brain; Dose-Response Relationship, Drug; Drug Interactions; gamma-A | 1999 |
[Gastroenterologic diseases and their relationship to the urogenital system].
Topics: Amyloidosis; Bile Acids and Salts; Celiac Disease; Cholelithiasis; Cholestyramine Resin; Colitis, Ul | 1978 |
Regulatory effect of neurotransmitter by hemofiltration in cardiogenic shock patients after open heart surgery.
Topics: Adolescent; Adult; Aged; Ammonia; Aspartic Acid; Brain Edema; Coronary Artery Bypass; Female; Glasgo | 1991 |
Hepatic coma and amino acids in the nerve endings of the central nervous system.
Topics: Amino Acids; Animals; Aspartic Acid; Brain; Cerebral Cortex; Glutamates; Glutamic Acid; Glycine; Hep | 1985 |
Inhibitory neuromodulators do not alter the course of experimental hepatic encephalopathy.
Topics: Adenosine; Animals; Caffeine; Cerebral Ventricles; Glycine; Hepatic Encephalopathy; Injections, Intr | 1988 |
Plasma amino acids in experimental acute hepatic failure and their relationship to brain tryptophan.
Topics: Acute Disease; Alanine; Amino Acids; Animals; Brain Chemistry; Disease Models, Animal; Glycine; Hepa | 1974 |