glycine has been researched along with Hemophilia B in 6 studies
Hemophilia B: A deficiency of blood coagulation factor IX inherited as an X-linked disorder. (Also known as Christmas Disease, after the first patient studied in detail, not the holy day.) Historical and clinical features resemble those in classic hemophilia (HEMOPHILIA A), but patients present with fewer symptoms. Severity of bleeding is usually similar in members of a single family. Many patients are asymptomatic until the hemostatic system is stressed by surgery or trauma. Treatment is similar to that for hemophilia A. (From Cecil Textbook of Medicine, 19th ed, p1008)
| Excerpt | Relevance | Reference |
|---|---|---|
| "A patient with severe haemophilia B with a glycine-to-valine missense mutation at residue 190 (c25, chymotrypsin numbering) in factor IX (FIX; FIX-G190V or FIX-FuChou) had <1% of normal FIX clotting activity and 36% of normal FIX antigen levels (cross-reacting material- reduced, CRMr)." | 1.37 | Characterisation of factor IX with a glycine-to-valine missense mutation at residue 190 in a patient with severe haemophilia B. ( Hamaguchi, N; Kao, CY; Kao, JT; Lin, CN; Lin, SW; Shen, MC; Yang, SJ; Yang, YL, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lu, Q | 1 |
| Yang, L | 1 |
| Manithody, C | 1 |
| Wang, X | 1 |
| Rezaie, AR | 1 |
| Kao, CY | 1 |
| Lin, CN | 2 |
| Yang, YL | 1 |
| Hamaguchi, N | 3 |
| Yang, SJ | 1 |
| Shen, MC | 3 |
| Kao, JT | 1 |
| Lin, SW | 3 |
| Smith, KJ | 2 |
| Larson, PJ | 1 |
| Stanfield-Oakley, SA | 1 |
| VanDusen, WJ | 1 |
| Kasper, CK | 1 |
| Monroe, DM | 1 |
| High, KA | 1 |
| Wu, PC | 1 |
| Yu, YS | 1 |
| Breckenridge, RT | 1 |
| Ratnoff, OD | 1 |
1 review available for glycine and Hemophilia B
| Article | Year |
|---|---|
Therapy of hereditary disorders of blood coagulation.
Topics: Abdomen, Acute; Afibrinogenemia; Blood Coagulation Disorders; Blood Transfusion; Cerebral Hemorrhage | 1968 |
5 other studies available for glycine and Hemophilia B
| Article | Year |
|---|---|
Expression and Characterization of Gly-317 Variants of Factor IX Causing Variable Bleeding in Hemophilia B Patients.
Topics: Amino Acid Substitution; Cysteine Endopeptidases; Enzyme Activation; Enzyme Precursors; Factor IX; F | 2015 |
Characterisation of factor IX with a glycine-to-valine missense mutation at residue 190 in a patient with severe haemophilia B.
Topics: Animals; Benzamidines; Factor IX; Gene Transfer Techniques; Glycine; HEK293 Cells; Hemophilia B; Hum | 2011 |
Characterization of a factor IX variant with a glycine207 to glutamic acid mutation.
Topics: Benzamidines; Binding Sites; Calcium; Codon; Computer Simulation; Electrophoresis, Polyacrylamide Ge | 1994 |
Structural integrity of the gamma-carboxyglutamic acid domain of human blood coagulation factor IXa Is required for its binding to cofactor VIIIa.
Topics: Adenine; Amino Acid Sequence; Arginine; Base Sequence; Binding Sites; DNA; DNA Mutational Analysis; | 1996 |
Hemophilia B with mutations at glycine-48 of factor IX exhibited delayed activation by the factor VIIa-tissue factor complex.
Topics: Animals; Blood Coagulation; Cattle; Factor IX; Factor VII; Glycine; Hemophilia B; Humans; Point Muta | 2000 |