glycine has been researched along with Glial Cell Tumors in 48 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "We measured glycine, 2-hydroxyglutarate (2HG), and other tumor-related metabolites in 35 glioma patients using an MRS sequence tailored for co-detection of glycine and 2HG in gadolinium-enhancing and non-enhancing tumor regions on 3T MRI." | 7.96 | Glycine by MR spectroscopy is an imaging biomarker of glioma aggressiveness. ( An, Z; Askari, P; Baxter, J; Choi, C; Daoud, EV; DeBerardinis, RJ; Dimitrov, I; Ganji, SK; Gao, A; Hatanpaa, KJ; Levy, M; Lewis, CM; Madden, CJ; Maher, EA; Malloy, CR; Mickey, BE; Pan, E; Patel, TR; Pinho, MC; Raisanen, JM; Sherry, AD; Thomas, BP; Tiwari, V; Zhang, S, 2020) |
| " As brain tumors are enriched in the neurotransmitter glycine, we studied the expression and function of glycine receptors (GlyRs) in glioma cells." | 7.80 | Intracellular glycine receptor function facilitates glioma formation in vivo. ( Benedetti, B; Dzaye, O; Fähling, M; Förstera, B; Glass, R; Junier, MP; Kettenmann, H; Markovic, DS; Meier, JC; Semtner, M; Synowitz, M; Wend, P; Winkelmann, A, 2014) |
| "Non-saturable penetration and the V and Km constants of saturable influx of leucine, lysine and glycine were always greater in cultured neuroblastoma (C1300) than in glioma (C6) cells." | 7.67 | Transport of leucine, lysine, glycine and aspartate in neuroblastoma C1300 and glioma C6 cells. ( Hannuniemi, R; Oja, OS; Oja, SS; Pajari-Backas, M, 1987) |
| "Human neuroblastoma SK-N-SH-SY5Y (5Y) and rat glioma (C6) cells were cultured with supplemental methionine, glycine, or serine for three to six days." | 7.66 | Effect of methionine, glycine and serine on serine hydroxymethyltransferase activity in rat glioma and human neuroblastoma cells. ( Kohl, RL; Perez-Polo, JR; Quay, WB, 1980) |
| "Glycine has been shown to possess important functions as a bidirectional neurotransmitter." | 5.35 | The regulation of glycine transporter GLYT1 is mainly mediated by protein kinase Calpha in C6 glioma cells. ( Abdin, JM; Dohi, T; Kitayama, T; Morioka, N; Morita, K; Nakata, Y, 2008) |
| "In 66 patients with advanced gliomas, ivosidenib was well tolerated, with no dose-limiting toxicities reported." | 5.34 | Ivosidenib in Isocitrate Dehydrogenase 1 ( Bowden, C; Burris, H; Choe, S; Cloughesy, TF; Cote, GM; De La Fuente, MI; Ellingson, BM; Fan, B; Holdhoff, M; Huang, R; Janku, F; Jiang, L; Lu, M; Maher, E; Mellinghoff, IK; Pandya, SS; Steelman, L; Touat, M; Wen, PY; Yen, K; Young, RJ, 2020) |
| "Gliotoxins are a group of amino acids that are toxic to astrocytes, and are substrates of high-affinity sodium-dependent glutamate transporters." | 5.32 | Gliotoxins disrupt alanine metabolism and glutathione production in C6 glioma cells: a 13C NMR spectroscopic study. ( Brennan, L; Hewage, C; Malthouse, JP; McBean, GJ, 2004) |
| "We measured glycine, 2-hydroxyglutarate (2HG), and other tumor-related metabolites in 35 glioma patients using an MRS sequence tailored for co-detection of glycine and 2HG in gadolinium-enhancing and non-enhancing tumor regions on 3T MRI." | 3.96 | Glycine by MR spectroscopy is an imaging biomarker of glioma aggressiveness. ( An, Z; Askari, P; Baxter, J; Choi, C; Daoud, EV; DeBerardinis, RJ; Dimitrov, I; Ganji, SK; Gao, A; Hatanpaa, KJ; Levy, M; Lewis, CM; Madden, CJ; Maher, EA; Malloy, CR; Mickey, BE; Pan, E; Patel, TR; Pinho, MC; Raisanen, JM; Sherry, AD; Thomas, BP; Tiwari, V; Zhang, S, 2020) |
| "5-Benzylglycinyl-amiloride (UCD38B) is the parent molecule of a class of anticancer small molecules that kill proliferative and nonproliferative high-grade glioma cells by programmed necrosis." | 3.81 | Mis-trafficking of endosomal urokinase proteins triggers drug-induced glioma nonapoptotic cell death. ( Gorin, F; Grodzki, AC; Pasupuleti, N, 2015) |
| " As brain tumors are enriched in the neurotransmitter glycine, we studied the expression and function of glycine receptors (GlyRs) in glioma cells." | 3.80 | Intracellular glycine receptor function facilitates glioma formation in vivo. ( Benedetti, B; Dzaye, O; Fähling, M; Förstera, B; Glass, R; Junier, MP; Kettenmann, H; Markovic, DS; Meier, JC; Semtner, M; Synowitz, M; Wend, P; Winkelmann, A, 2014) |
| " The aim of this study was to evaluate the effect of methylglyoxal exposure, over short (1 and 3 h) and long term (24 h) periods, on glucose, glycine and lactate metabolism in C6 glioma cells, as well as investigate the glyoxalase system and AGEs formation." | 3.78 | Methylglyoxal alters glucose metabolism and increases AGEs content in C6 glioma cells. ( Bobermin, LD; de Souza, DF; Fontoura, JB; Gonçalves, CA; Hansen, F; Hoefel, AL; Leite, MC; Perry, ML; Silveira, Sda L; Tramontina, AC, 2012) |
| "55 ppm in a long echo time (TE) recognized as glycine (Gly) in the WHO grade II gliomas and central neurocytomas by means of 1H MRS." | 3.76 | Measurement of glycine in a brain and brain tumors by means of 1H MRS. ( Bobek-Billewicz, B; Hebda, A; Majchrzak, K; Stasik-Pres, G; Trojanowska, A; Zmuda, E, 2010) |
| "The effects of arachidonic acid on glycine uptake, exchange and efflux in C6 glioma cells were investigated." | 3.68 | Arachidonic acid inhibits glycine transport in cultured glial cells. ( Alcantara, R; Aragon, C; Gimenez, C; Gomeza, J; Zafra, F, 1990) |
| "The transport of glycine in C6 glioma cells takes place mainly in a heterogeneous Na+-dependent manner which can be resolved into different components." | 3.67 | Characteristics and adaptive regulation of glycine transport in cultured glial cells. ( Giménez, C; Zafra, F, 1989) |
| "Non-saturable penetration and the V and Km constants of saturable influx of leucine, lysine and glycine were always greater in cultured neuroblastoma (C1300) than in glioma (C6) cells." | 3.67 | Transport of leucine, lysine, glycine and aspartate in neuroblastoma C1300 and glioma C6 cells. ( Hannuniemi, R; Oja, OS; Oja, SS; Pajari-Backas, M, 1987) |
| "Human neuroblastoma SK-N-SH-SY5Y (5Y) and rat glioma (C6) cells were cultured with supplemental methionine, glycine, or serine for three to six days." | 3.66 | Effect of methionine, glycine and serine on serine hydroxymethyltransferase activity in rat glioma and human neuroblastoma cells. ( Kohl, RL; Perez-Polo, JR; Quay, WB, 1980) |
| "H3." | 1.56 | Reciprocal H3.3 gene editing identifies K27M and G34R mechanisms in pediatric glioma including NOTCH signaling. ( Bush, K; Carcaboso, AM; Cervantes, V; Chen, KY; Klein, RH; Knoepfler, PS; Lechpammer, M; Lewis, N; Naqvi, A, 2020) |
| "Therefore, H3G34R/V/D mutations promote genome instability and tumorigenesis by inhibiting MMR activity." | 1.48 | Cancer-driving H3G34V/R/D mutations block H3K36 methylation and H3K36me3-MutSα interaction. ( Fang, J; Gu, L; Huang, Y; Li, GM; Li, H; Mao, G; Rennert, G; Yang, S, 2018) |
| "Glycine has been shown to possess important functions as a bidirectional neurotransmitter." | 1.35 | The regulation of glycine transporter GLYT1 is mainly mediated by protein kinase Calpha in C6 glioma cells. ( Abdin, JM; Dohi, T; Kitayama, T; Morioka, N; Morita, K; Nakata, Y, 2008) |
| "Gliotoxins are a group of amino acids that are toxic to astrocytes, and are substrates of high-affinity sodium-dependent glutamate transporters." | 1.32 | Gliotoxins disrupt alanine metabolism and glutathione production in C6 glioma cells: a 13C NMR spectroscopic study. ( Brennan, L; Hewage, C; Malthouse, JP; McBean, GJ, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (18.75) | 18.7374 |
| 1990's | 10 (20.83) | 18.2507 |
| 2000's | 6 (12.50) | 29.6817 |
| 2010's | 13 (27.08) | 24.3611 |
| 2020's | 10 (20.83) | 2.80 |
| Authors | Studies |
|---|---|
| Sweha, SR | 1 |
| Chung, C | 1 |
| Natarajan, SK | 1 |
| Panwalkar, P | 1 |
| Pun, M | 1 |
| Ghali, A | 1 |
| Bayliss, J | 1 |
| Pratt, D | 1 |
| Shankar, A | 1 |
| Ravikumar, V | 1 |
| Rao, A | 1 |
| Cieslik, M | 1 |
| Wilder-Romans, K | 1 |
| Scott, AJ | 1 |
| Wahl, DR | 1 |
| Jessa, S | 1 |
| Kleinman, CL | 1 |
| Jabado, N | 1 |
| Mackay, A | 1 |
| Jones, C | 1 |
| Martinez, D | 1 |
| Santi, M | 1 |
| Judkins, AR | 1 |
| Yadav, VN | 1 |
| Qin, T | 1 |
| Phoenix, TN | 1 |
| Koschmann, CJ | 1 |
| Baker, SJ | 1 |
| Chinnaiyan, AM | 1 |
| Venneti, S | 1 |
| Ellingson, BM | 2 |
| Kim, GHJ | 1 |
| Brown, M | 1 |
| Lee, J | 1 |
| Salamon, N | 1 |
| Steelman, L | 2 |
| Hassan, I | 1 |
| Pandya, SS | 2 |
| Chun, S | 1 |
| Linetsky, M | 1 |
| Yoo, B | 1 |
| Wen, PY | 2 |
| Mellinghoff, IK | 2 |
| Goldin, J | 1 |
| Cloughesy, TF | 2 |
| Gerstner, ER | 1 |
| Vuong, HG | 1 |
| Le, HT | 1 |
| Dunn, IF | 1 |
| Tiwari, V | 1 |
| Daoud, EV | 1 |
| Hatanpaa, KJ | 1 |
| Gao, A | 1 |
| Zhang, S | 1 |
| An, Z | 1 |
| Ganji, SK | 1 |
| Raisanen, JM | 1 |
| Lewis, CM | 1 |
| Askari, P | 1 |
| Baxter, J | 1 |
| Levy, M | 1 |
| Dimitrov, I | 1 |
| Thomas, BP | 1 |
| Pinho, MC | 1 |
| Madden, CJ | 1 |
| Pan, E | 1 |
| Patel, TR | 1 |
| DeBerardinis, RJ | 1 |
| Sherry, AD | 1 |
| Mickey, BE | 1 |
| Malloy, CR | 1 |
| Maher, EA | 1 |
| Choi, C | 1 |
| Keunen, O | 1 |
| Niclou, SP | 1 |
| Touat, M | 1 |
| Maher, E | 1 |
| De La Fuente, MI | 1 |
| Holdhoff, M | 1 |
| Cote, GM | 1 |
| Burris, H | 1 |
| Janku, F | 1 |
| Young, RJ | 1 |
| Huang, R | 1 |
| Jiang, L | 1 |
| Choe, S | 1 |
| Fan, B | 1 |
| Yen, K | 1 |
| Lu, M | 1 |
| Bowden, C | 1 |
| Chen, KY | 1 |
| Bush, K | 1 |
| Klein, RH | 1 |
| Cervantes, V | 1 |
| Lewis, N | 1 |
| Naqvi, A | 1 |
| Carcaboso, AM | 1 |
| Lechpammer, M | 1 |
| Knoepfler, PS | 1 |
| Molloy, AR | 1 |
| Najac, C | 1 |
| Viswanath, P | 1 |
| Lakhani, A | 1 |
| Subramani, E | 1 |
| Batsios, G | 1 |
| Radoul, M | 1 |
| Gillespie, AM | 1 |
| Pieper, RO | 1 |
| Ronen, SM | 1 |
| Liu, R | 1 |
| Zeng, LW | 1 |
| Gong, R | 1 |
| Yuan, F | 1 |
| Shu, HB | 1 |
| Li, S | 1 |
| Leske, H | 1 |
| Rushing, E | 1 |
| Budka, H | 1 |
| Niehusmann, P | 1 |
| Pahnke, J | 1 |
| Panagopoulos, I | 1 |
| Fang, J | 1 |
| Huang, Y | 1 |
| Mao, G | 1 |
| Yang, S | 1 |
| Rennert, G | 1 |
| Gu, L | 1 |
| Li, H | 1 |
| Li, GM | 1 |
| Kato, Y | 1 |
| Natsume, A | 1 |
| Kaneko, MK | 1 |
| Förstera, B | 1 |
| Dzaye, O | 1 |
| Winkelmann, A | 1 |
| Semtner, M | 1 |
| Benedetti, B | 1 |
| Markovic, DS | 1 |
| Synowitz, M | 1 |
| Wend, P | 1 |
| Fähling, M | 1 |
| Junier, MP | 1 |
| Glass, R | 1 |
| Kettenmann, H | 1 |
| Meier, JC | 1 |
| Pasupuleti, N | 1 |
| Grodzki, AC | 1 |
| Gorin, F | 1 |
| Thomas, AG | 1 |
| Sattler, R | 1 |
| Tendyke, K | 1 |
| Loiacono, KA | 1 |
| Hansen, H | 1 |
| Sahni, V | 1 |
| Hashizume, Y | 1 |
| Rojas, C | 1 |
| Slusher, BS | 1 |
| Ghasemi, K | 1 |
| Khanmohammadi, M | 1 |
| Saligheh Rad, H | 1 |
| Solomon, DA | 1 |
| Wood, MD | 1 |
| Tihan, T | 1 |
| Bollen, AW | 1 |
| Gupta, N | 1 |
| Phillips, JJ | 1 |
| Perry, A | 1 |
| Morioka, N | 1 |
| Abdin, JM | 1 |
| Morita, K | 1 |
| Kitayama, T | 1 |
| Nakata, Y | 1 |
| Dohi, T | 1 |
| Kim, EM | 1 |
| Park, EH | 1 |
| Cheong, SJ | 1 |
| Lee, CM | 1 |
| Kim, DW | 1 |
| Jeong, HJ | 1 |
| Lim, ST | 1 |
| Sohn, MH | 1 |
| Kim, K | 1 |
| Chung, J | 1 |
| Bobek-Billewicz, B | 1 |
| Hebda, A | 1 |
| Stasik-Pres, G | 1 |
| Majchrzak, K | 1 |
| Zmuda, E | 1 |
| Trojanowska, A | 1 |
| Wang, YY | 1 |
| Liu, SC | 1 |
| Yang, Z | 1 |
| Zhang, T | 1 |
| Custódio, AC | 1 |
| Almeida, LO | 1 |
| Pinto, GR | 1 |
| Santos, MJ | 1 |
| Almeida, JR | 1 |
| Clara, CA | 1 |
| Rey, JA | 1 |
| Casartelli, C | 1 |
| Shah, T | 1 |
| Jayasundar, R | 1 |
| Singh, VP | 1 |
| Sarkar, C | 1 |
| Hansen, F | 1 |
| de Souza, DF | 1 |
| Silveira, Sda L | 1 |
| Hoefel, AL | 1 |
| Fontoura, JB | 1 |
| Tramontina, AC | 1 |
| Bobermin, LD | 1 |
| Leite, MC | 1 |
| Perry, ML | 1 |
| Gonçalves, CA | 1 |
| Pearlman, RJ | 1 |
| Aubrey, KR | 1 |
| Vandenberg, RJ | 1 |
| Javitt, DC | 1 |
| Duncan, L | 1 |
| Balla, A | 1 |
| Sershen, H | 1 |
| Brennan, L | 1 |
| Hewage, C | 1 |
| Malthouse, JP | 1 |
| McBean, GJ | 1 |
| Tong, ZY | 1 |
| Toshiaki, Y | 1 |
| Wang, YJ | 1 |
| Kohl, RL | 2 |
| Quay, WB | 2 |
| Perez-Polo, JR | 2 |
| Hagberg, G | 1 |
| Burlina, AP | 1 |
| Mader, I | 1 |
| Roser, W | 1 |
| Radue, EW | 1 |
| Seelig, J | 1 |
| Kinoshita, Y | 1 |
| Kajiwara, H | 1 |
| Yokota, A | 1 |
| Koga, Y | 1 |
| Ohkuma, S | 1 |
| Katsura, M | 1 |
| Chen, DZ | 1 |
| Chen, SH | 1 |
| Kuriyama, K | 1 |
| Dowd, LA | 1 |
| Robinson, MB | 2 |
| Egorova, A | 1 |
| Hoshi, N | 1 |
| Knijnik, R | 1 |
| Shahidullah, M | 1 |
| Hashii, M | 1 |
| Noda, M | 1 |
| Higashida, H | 1 |
| Davis, KE | 1 |
| Straff, DJ | 1 |
| Weinstein, EA | 1 |
| Bannerman, PG | 1 |
| Correale, DM | 1 |
| Rothstein, JD | 2 |
| Ye, ZC | 2 |
| Sontheimer, H | 2 |
| Henn, FA | 1 |
| Skaper, SD | 1 |
| Seegmiller, JE | 1 |
| Skalski, V | 1 |
| Feindel, W | 1 |
| Panasci, LC | 1 |
| Zafra, F | 4 |
| Alcantara, R | 1 |
| Gomeza, J | 1 |
| Aragon, C | 1 |
| Gimenez, C | 4 |
| Le Moyec, L | 1 |
| Naruse, S | 1 |
| Higuchi, T | 1 |
| Hirakawa, K | 1 |
| Watari, H | 1 |
| de Certaines, JD | 1 |
| Roques, BP | 1 |
| Hannuniemi, R | 1 |
| Pajari-Backas, M | 1 |
| Oja, OS | 1 |
| Oja, SS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase 1, Multicenter, Open-Label, Dose-Escalation and Expansion, Safety, Pharmacokinetic, Pharmacodynamic, and Clinical Activity Study of Orally Administered AG-120 in Subjects With Advanced Solid Tumors, Including Glioma, With an IDH1 Mutation[NCT02073994] | Phase 1 | 170 participants (Anticipated) | Interventional | 2014-03-01 | Active, not recruiting | ||
| The Effects of Glycine Transport Inhibition on Brain Glycine Concentration[NCT00538070] | 68 participants (Actual) | Interventional | 2007-08-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for glycine and Glial Cell Tumors
| Article | Year |
|---|---|
The prognostic significance of further genotyping H3G34 diffuse hemispheric gliomas.
Topics: Brain Neoplasms; Genotype; Glioma; Glycine; Humans; Prognosis | 2022 |
2 trials available for glycine and Glial Cell Tumors
| Article | Year |
|---|---|
Volumetric measurements are preferred in the evaluation of mutant IDH inhibition in non-enhancing diffuse gliomas: Evidence from a phase I trial of ivosidenib.
Topics: Brain Neoplasms; Glioma; Glycine; Humans; Isocitrate Dehydrogenase; Magnetic Resonance Imaging; Pyri | 2022 |
Ivosidenib in Isocitrate Dehydrogenase 1
Topics: Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Dose-Response Relationship, Drug; Enzyme Inhibi | 2020 |
45 other studies available for glycine and Glial Cell Tumors
| Article | Year |
|---|---|
Epigenetically defined therapeutic targeting in H3.3G34R/V high-grade gliomas.
Topics: Animals; Brain Neoplasms; Epigenesis, Genetic; Glioma; Glycine; Histones; Humans; Mice | 2021 |
Volumetric measurements in low-grade glioma: Are we there yet?
Topics: Glioma; Glycine; Humans; Pyridines | 2022 |
Glycine by MR spectroscopy is an imaging biomarker of glioma aggressiveness.
Topics: Adult; Aged; Biomarkers; Brain Neoplasms; Contrast Media; Female; Gadolinium; Glioma; Glutarates; Gl | 2020 |
Is there a prominent role for MR spectroscopy in the clinical management of brain tumors?
Topics: Biomarkers; Brain Neoplasms; Glioma; Glycine; Humans; Magnetic Resonance Spectroscopy | 2020 |
Reciprocal H3.3 gene editing identifies K27M and G34R mechanisms in pediatric glioma including NOTCH signaling.
Topics: Animals; Apoptosis; Biomarkers, Tumor; Brain Neoplasms; Cell Proliferation; Child; Female; Gene Edit | 2020 |
MR-detectable metabolic biomarkers of response to mutant IDH inhibition in low-grade glioma.
Topics: Antineoplastic Agents; Biomarkers, Tumor; Brain Neoplasms; Carbon-13 Magnetic Resonance Spectroscopy | 2020 |
mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis.
Topics: Acetyl-CoA C-Acetyltransferase; Acetylation; Animals; Carcinogenesis; Cell Line, Tumor; Gene Express | 2021 |
K27/G34 versus K28/G35 in histone H3-mutant gliomas: A note of caution.
Topics: Brain Neoplasms; DNA Mutational Analysis; Glioma; Glycine; Histones; Humans; Lysine; Mutation | 2018 |
Cancer-driving H3G34V/R/D mutations block H3K36 methylation and H3K36me3-MutSα interaction.
Topics: Carcinogenesis; Cell Line, Tumor; Child; DNA Mismatch Repair; Genomic Instability; Glioma; Glycine; | 2018 |
A novel monoclonal antibody GMab-m1 specifically recognizes IDH1-R132G mutation.
Topics: Amino Acid Substitution; Animals; Antibodies, Monoclonal; Arginine; Cell Line; Cricetinae; Glioma; G | 2013 |
Intracellular glycine receptor function facilitates glioma formation in vivo.
Topics: Animals; Cell Line; Cytoplasm; Disease Models, Animal; Gene Expression Regulation; Gene Knockdown Te | 2014 |
Mis-trafficking of endosomal urokinase proteins triggers drug-induced glioma nonapoptotic cell death.
Topics: Amiloride; Antineoplastic Agents; Apoptosis Inducing Factor; Brain Neoplasms; Cell Line, Tumor; Endo | 2015 |
High-Throughput Assay Development for Cystine-Glutamate Antiporter (xc-) Highlights Faster Cystine Uptake than Glutamate Release in Glioma Cells.
Topics: Amino Acid Transport System y+; Benzoates; Brain Neoplasms; Cell Line, Tumor; Cystine; Databases, Ch | 2015 |
Accurate grading of brain gliomas by soft independent modeling of class analogy based on non-negative matrix factorization of proton magnetic resonance spectra.
Topics: Algorithms; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Glioma; Glycine; Humans; Neoplasm Gra | 2016 |
Diffuse Midline Gliomas with Histone H3-K27M Mutation: A Series of 47 Cases Assessing the Spectrum of Morphologic Variation and Associated Genetic Alterations.
Topics: Adolescent; Adult; Aged; Brain Neoplasms; Child; Child, Preschool; ErbB Receptors; Female; Gene Expr | 2016 |
The regulation of glycine transporter GLYT1 is mainly mediated by protein kinase Calpha in C6 glioma cells.
Topics: Animals; Astrocytes; Calcium; Carcinogens; Cell Line, Tumor; Diterpenes; Down-Regulation; Enzyme Inh | 2008 |
Characterization, biodistribution and small-animal SPECT of I-125-labeled c-Met binding peptide in mice bearing c-Met receptor tyrosine kinase-positive tumor xenografts.
Topics: Amino Acid Sequence; Animals; Binding, Competitive; Biological Transport; Blotting, Western; Capryla | 2009 |
Measurement of glycine in a brain and brain tumors by means of 1H MRS.
Topics: Adult; Brain Chemistry; Brain Neoplasms; Female; Glioma; Glycine; Humans; Magnetic Resonance Imaging | 2010 |
Impaired hippocampal synaptic plasticity in C6 glioma-bearing rats.
Topics: Animals; Body Weight; Brain Neoplasms; Cell Line, Tumor; Chromatography, High Pressure Liquid; Disea | 2011 |
Analysis of the polymorphisms XRCC1Arg194Trp and XRCC1Arg399Gln in gliomas.
Topics: Arginine; Brain Neoplasms; DNA Primers; DNA-Binding Proteins; Glioma; Glycine; Humans; Polymerase Ch | 2011 |
In vivo MRS study of intraventricular tumors.
Topics: Adolescent; Adult; Brain Neoplasms; Cerebral Ventricle Neoplasms; Diagnosis, Differential; Female; G | 2011 |
Methylglyoxal alters glucose metabolism and increases AGEs content in C6 glioma cells.
Topics: Cell Line, Tumor; Coloring Agents; Energy Metabolism; Glioma; Glucose; Glycation End Products, Advan | 2012 |
Arachidonic acid and anandamide have opposite modulatory actions at the glycine transporter, GLYT1a.
Topics: Amino Acid Transport Systems, Neutral; Animals; Arachidonic Acid; Arachidonic Acids; Biological Tran | 2003 |
Inhibition of system A-mediated glycine transport in cortical synaptosomes by therapeutic concentrations of clozapine: implications for mechanisms of action.
Topics: Amino Acid Transport System A; Amino Acids; Animals; Antipsychotic Agents; beta-Alanine; Cell Line, | 2005 |
Gliotoxins disrupt alanine metabolism and glutathione production in C6 glioma cells: a 13C NMR spectroscopic study.
Topics: Alanine; Alanine Transaminase; Brain Neoplasms; Cell Line, Tumor; Dicarboxylic Acids; Enzyme Inhibit | 2004 |
Proton magnetic resonance spectroscopy of normal human brain and glioma: a quantitative in vivo study.
Topics: Adult; Aspartic Acid; Brain; Choline; Creatine; Female; Glioma; Glycine; Humans; Inositol; Magnetic | 2005 |
Elevation of gamma-aminobutyric acid in cultured rat C6 glioma cells following methionine supplementation.
Topics: Amino Acids; Animals; Cell Line; gamma-Aminobutyric Acid; Glioma; Glycine; Methionine; Rats; Serine | 1980 |
Effect of methionine, glycine and serine on serine hydroxymethyltransferase activity in rat glioma and human neuroblastoma cells.
Topics: Animals; Brain Neoplasms; Cell Line; Enzyme Activation; Glioma; Glycine; Glycine Hydroxymethyltransf | 1980 |
In vivo proton MR spectroscopy of human gliomas: definition of metabolic coordinates for multi-dimensional classification.
Topics: Adult; Aspartic Acid; Astrocytoma; Brain Neoplasms; Choline; Cluster Analysis; Creatine; Discriminan | 1995 |
Proton magnetic resonance spectroscopy of astrocytic tumors: an in vitro study.
Topics: Antibodies, Monoclonal; Astrocytoma; Brain Neoplasms; Choline; Creatine; Diagnosis, Differential; Fe | 1993 |
Presence of N-methyl-D-aspartate (NMDA) receptors in neuroblastoma x glioma hybrid NG108-15 cells-analysis using [45Ca2+]influx and [3H]MK-801 binding as functional measures.
Topics: Calcium Radioisotopes; Cations, Divalent; Dizocilpine Maleate; Glioma; Glutamates; Glutamic Acid; Gl | 1994 |
Rapid stimulation of EAAC1-mediated Na+-dependent L-glutamate transport activity in C6 glioma cells by phorbol ester.
Topics: Adenylyl Cyclases; Amiloride; Amino Acid Transport System X-AG; Animals; Aspartic Acid; ATP-Binding | 1996 |
Sulfhydryl modification inhibits K+ (M) current with kinetics close to acetylcholine in rodent NG108-15 cells.
Topics: Acetylcholine; Animals; Cysteine; Glioma; Glutathione; Glutathione Disulfide; Glycine; Hybrid Cells; | 1997 |
Multiple signaling pathways regulate cell surface expression and activity of the excitatory amino acid carrier 1 subtype of Glu transporter in C6 glioma.
Topics: Amino Acid Transport System X-AG; Androstadienes; Animals; Biological Transport; Carcinogens; Carrie | 1998 |
Glioma cells release excitotoxic concentrations of glutamate.
Topics: Animals; Benzoates; Biological Transport; Cell Line; Coculture Techniques; Excitatory Amino Acid Ant | 1999 |
Compromised glutamate transport in human glioma cells: reduction-mislocalization of sodium-dependent glutamate transporters and enhanced activity of cystine-glutamate exchange.
Topics: Amino Acid Substitution; Amino Acid Transport System X-AG; Animals; Astrocytes; ATP-Binding Cassette | 1999 |
Neurotransmission and glial cells: a functional relationship?
Topics: Amino Acids; Animals; Biological Transport, Active; Brain; Calcium; gamma-Aminobutyric Acid; Glioma; | 1976 |
Elevated intracellular glycine associated with hypoxanthine-guanine phosphoribosyltransferase deficiency in glioma cells.
Topics: Amino Acids; Animals; Cell Division; Cell Line; Chick Embryo; Dogs; Glioma; Glycine; Hypoxanthine Ph | 1977 |
Transport of amino acid amide sarcosinamide and sarcosinamide chloroethylnitrosourea in human glioma SK-MG-1 cells.
Topics: Biological Transport, Active; Carmustine; Glioma; Glycine; Humans; Hydrogen-Ion Concentration; In Vi | 1990 |
Arachidonic acid inhibits glycine transport in cultured glial cells.
Topics: Arachidonic Acid; Arachidonic Acids; Biological Transport; Cell Membrane; Cell Membrane Permeability | 1990 |
In vivo 31P MRS in new antineoplastic agents evaluation on experimental tumor models.
Topics: Animals; Antineoplastic Agents; Carbazoles; Carcinoma 256, Walker; Energy Metabolism; Female; Glioma | 1988 |
Characteristics and adaptive regulation of glycine transport in cultured glial cells.
Topics: Amino Acids; Animals; Biological Transport; Cycloheximide; Dactinomycin; Glioma; Glycine; Hydrogen-I | 1989 |
Characterization of glycine uptake in plasma membrane vesicles isolated from cultured glioblastoma cells.
Topics: Biological Transport; Cell Line; Cell Membrane; Glioma; Glycine; Kinetics; Nigericin; Onium Compound | 1986 |
Transport of leucine, lysine, glycine and aspartate in neuroblastoma C1300 and glioma C6 cells.
Topics: Animals; Aspartic Acid; Cell Line, Transformed; Glioma; Glycine; Humans; Leucine; Lysine; Neuroblast | 1987 |
Efflux and exchange of glycine by plasma membrane vesicles isolated from glioblastoma cells.
Topics: Azo Compounds; Biological Transport; Cell Membrane; Chlorides; Glioma; Glycine; In Vitro Techniques; | 1988 |