glycine has been researched along with Drug Withdrawal Symptoms in 25 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "Here, we report that following two exposures to morphine (20 mg/kg, sc) each followed by naloxone (1 mg/kg, sc) 24 h later, rats display nausea-like somatic reactions of lying flattened on belly, abdominal contractions and diarrhea, and display increased mouthing movements and loss of body weight." | 7.96 | Acute naloxone-precipitated morphine withdrawal elicits nausea-like somatic behaviors in rats in a manner suppressed by N-oleoylglycine. ( Ayoub, SM; DeVuono, MV; Di Marzo, V; Gene, A; Lichtman, AH; Limebeer, CL; Mechoulam, R; Parker, LA; Rock, EM; Smoum, R; Wills, KL, 2020) |
| " The contribution of various excitatory amino acid (EAA) receptors (NMDA, AMPA/kainate and metabotropic) in the brain to the development of morphine dependence was examined." | 7.69 | Effect of activity at metabotropic, as well as ionotropic (NMDA), glutamate receptors on morphine dependence. ( Coderre, TJ; Fundytus, ME, 1994) |
| "Glycine's effect was blocked by strychnine, a GlyR antagonist, indicating that it was mediated by strychnine-sensitive GlyRs." | 5.51 | Activation of glycine receptors in the lateral habenula rescues anxiety- and depression-like behaviors associated with alcohol withdrawal and reduces alcohol intake in rats. ( Fu, R; Li, W; Ndukwe, M; Wu, L; Wu, W; Ye, JH; Zhang, H; Zuo, QK; Zuo, W, 2019) |
| "Here, we report that following two exposures to morphine (20 mg/kg, sc) each followed by naloxone (1 mg/kg, sc) 24 h later, rats display nausea-like somatic reactions of lying flattened on belly, abdominal contractions and diarrhea, and display increased mouthing movements and loss of body weight." | 3.96 | Acute naloxone-precipitated morphine withdrawal elicits nausea-like somatic behaviors in rats in a manner suppressed by N-oleoylglycine. ( Ayoub, SM; DeVuono, MV; Di Marzo, V; Gene, A; Lichtman, AH; Limebeer, CL; Mechoulam, R; Parker, LA; Rock, EM; Smoum, R; Wills, KL, 2020) |
| "Cigarette smokers with brain damage involving the insular cortex display cessation of tobacco smoking, suggesting that this region may contribute to nicotine addiction." | 3.91 | N-Oleoyl-glycine reduces nicotine reward and withdrawal in mice. ( D'Aniello, E; Damaj, MI; Di Marzo, V; Donvito, G; Giordano, C; Guida, F; Ignatowska-Jankowska, BM; Jackson, A; Lichtman, AH; Maione, S; Mechoulam, R; Muldoon, P; Mustafa, MA; Parker, L; Petrie, GN; Piscitelli, F; Sim-Selley, L; Smoum, R; Vitale, RM, 2019) |
| " The contribution of various excitatory amino acid (EAA) receptors (NMDA, AMPA/kainate and metabotropic) in the brain to the development of morphine dependence was examined." | 3.69 | Effect of activity at metabotropic, as well as ionotropic (NMDA), glutamate receptors on morphine dependence. ( Coderre, TJ; Fundytus, ME, 1994) |
| "Neonatal seizures, as distinguished from nonconvulsive abnormal movements, are a significant problem in neonatal intensive care units." | 2.37 | Neonatal seizures. ( Bergman, I; Crumrine, P; Painter, MJ, 1986) |
| "Glycine's effect was blocked by strychnine, a GlyR antagonist, indicating that it was mediated by strychnine-sensitive GlyRs." | 1.51 | Activation of glycine receptors in the lateral habenula rescues anxiety- and depression-like behaviors associated with alcohol withdrawal and reduces alcohol intake in rats. ( Fu, R; Li, W; Ndukwe, M; Wu, L; Wu, W; Ye, JH; Zhang, H; Zuo, QK; Zuo, W, 2019) |
| "Alcohol dependence is a heterogeneous disorder where several signalling systems play important roles." | 1.39 | Ghrelin receptor (GHS-R1A) antagonism suppresses both alcohol consumption and the alcohol deprivation effect in rats following long-term voluntary alcohol consumption. ( Engel, JA; Fredriksson, I; Jerlhag, E; Steensland, P; Suchankova, P, 2013) |
| "The present study investigates the effects of acute and chronic administration of triazolam in albino rats on glycine levels in different brain areas." | 1.31 | Brain glycine levels in triazolam-treated albino rats. ( Aburawi, SM; Ahmed, SS; Attia, AS; Elhwuegi, AS; Saad, SF, 2001) |
| "The effect of chronic administration of morphine to rats on the N-methyl-D-aspartate (NMDA) receptors labeled with [3H]MK-801, a non-competitive antagonist, was determined in brain regions and spinal cord." | 1.29 | Effect of morphine tolerance and abstinence on the binding of [3H]MK-801 to brain regions and spinal cord of the rat. ( Bhargava, HN; Gudehithlu, KP; Reddy, PL, 1994) |
| "Diazepam was ineffective in the analgesic test and it did not alter morphine analgesia, except when administered in a high dose which decreased and analgesic response." | 1.26 | Effects of glycine, beta-alanine and diazepam upon morphine-tolerant-dependent mice. ( Contreras, E; Tamayo, L, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (24.00) | 18.7374 |
| 1990's | 6 (24.00) | 18.2507 |
| 2000's | 3 (12.00) | 29.6817 |
| 2010's | 7 (28.00) | 24.3611 |
| 2020's | 3 (12.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rock, EM | 3 |
| Ayoub, SM | 2 |
| Limebeer, CL | 3 |
| Gene, A | 1 |
| Wills, KL | 2 |
| DeVuono, MV | 1 |
| Smoum, R | 4 |
| Di Marzo, V | 4 |
| Lichtman, AH | 4 |
| Mechoulam, R | 4 |
| Parker, LA | 3 |
| Farag, M | 1 |
| Atwal, H | 1 |
| Collins, SA | 1 |
| Piscitelli, F | 3 |
| Iannotti, FA | 1 |
| Leri, F | 1 |
| Steinegger, CA | 1 |
| Zoelch, N | 1 |
| Hock, A | 1 |
| Henning, A | 1 |
| Engeli, EJE | 1 |
| Seifritz, E | 1 |
| Hulka, LM | 1 |
| Herdener, M | 1 |
| Donvito, G | 1 |
| Muldoon, P | 1 |
| Jackson, A | 1 |
| Vitale, RM | 1 |
| D'Aniello, E | 1 |
| Giordano, C | 1 |
| Ignatowska-Jankowska, BM | 1 |
| Mustafa, MA | 1 |
| Guida, F | 1 |
| Petrie, GN | 2 |
| Parker, L | 1 |
| Sim-Selley, L | 1 |
| Maione, S | 1 |
| Damaj, MI | 1 |
| Humphrey, AE | 1 |
| Sheppard-Perkins, M | 1 |
| Li, W | 1 |
| Zuo, W | 1 |
| Wu, W | 1 |
| Zuo, QK | 1 |
| Fu, R | 1 |
| Wu, L | 1 |
| Zhang, H | 1 |
| Ndukwe, M | 1 |
| Ye, JH | 1 |
| Suchankova, P | 1 |
| Steensland, P | 1 |
| Fredriksson, I | 1 |
| Engel, JA | 1 |
| Jerlhag, E | 1 |
| Scheyer, AF | 1 |
| Wolf, ME | 1 |
| Tseng, KY | 1 |
| Huang, CC | 1 |
| Liang, YC | 1 |
| Lee, CC | 1 |
| Hsu, KS | 1 |
| Alén, F | 1 |
| Santos, A | 1 |
| Moreno-Sanz, G | 1 |
| González-Cuevas, G | 1 |
| Giné, E | 1 |
| Franco-Ruiz, L | 1 |
| Navarro, M | 1 |
| López-Moreno, JA | 1 |
| Krishnan, B | 1 |
| Genzer, KM | 1 |
| Pollandt, SW | 1 |
| Liu, J | 1 |
| Gallagher, JP | 1 |
| Shinnick-Gallagher, P | 1 |
| Contreras, E | 1 |
| Tamayo, L | 1 |
| Rosenblatt, S | 1 |
| Leighton, WP | 1 |
| Chanley, JD | 1 |
| Carter, LA | 1 |
| Belknap, JK | 1 |
| Crabbe, JC | 2 |
| Janowsky, A | 1 |
| Fundytus, ME | 1 |
| Coderre, TJ | 1 |
| Gudehithlu, KP | 1 |
| Reddy, PL | 1 |
| Bhargava, HN | 1 |
| Cappendijk, SL | 1 |
| de Vries, R | 1 |
| Dzoljic, MR | 1 |
| Jhamandas, KH | 1 |
| Marsala, M | 1 |
| Ibuki, T | 1 |
| Yaksh, TL | 1 |
| Snell, LD | 1 |
| Claffey, DJ | 1 |
| Ruth, JA | 1 |
| Valenzuela, CF | 1 |
| Cardoso, R | 1 |
| Wang, Z | 1 |
| Levinson, SR | 1 |
| Sather, WA | 1 |
| Williamson, AV | 1 |
| Ingersoll, NC | 1 |
| Ovchinnikova, L | 1 |
| Bhave, SV | 1 |
| Hoffman, PL | 2 |
| Tabakoff, B | 2 |
| Aburawi, SM | 1 |
| Ahmed, SS | 1 |
| Elhwuegi, AS | 1 |
| Saad, SF | 1 |
| Attia, AS | 1 |
| Cooper, BR | 1 |
| Viik, K | 1 |
| Ferris, RM | 1 |
| White, HL | 1 |
| Filipović, N | 1 |
| Stern, P | 2 |
| Fuks, Z | 1 |
| Valverius, P | 1 |
| Painter, MJ | 1 |
| Bergman, I | 1 |
| Crumrine, P | 1 |
| Stern, M | 1 |
1 review available for glycine and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
Neonatal seizures.
Topics: Adrenoleukodystrophy; Amino Acid Metabolism, Inborn Errors; Ammonia; Anesthetics, Local; Anticonvuls | 1986 |
24 other studies available for glycine and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
Acute naloxone-precipitated morphine withdrawal elicits nausea-like somatic behaviors in rats in a manner suppressed by N-oleoylglycine.
Topics: Animals; Female; Glycine; Male; Medically Unexplained Symptoms; Morphine; Morphine Dependence; Nalox | 2020 |
Oleoyl alanine (HU595): a stable monomethylated oleoyl glycine interferes with acute naloxone precipitated morphine withdrawal in male rats.
Topics: Alanine; Analgesics, Opioid; Animals; Glycine; Male; Morphine; Morphine Dependence; Naloxone; Narcot | 2020 |
Neurometabolic alterations in the nucleus accumbens of smokers assessed with
Topics: Adult; Glutamates; Glutamic Acid; Glutamine; Glycine; Humans; Inflammation Mediators; Inositol; Magn | 2021 |
N-Oleoyl-glycine reduces nicotine reward and withdrawal in mice.
Topics: Animals; Brain Injuries, Traumatic; Cerebral Cortex; Conditioning, Classical; Glycine; Male; Mecamyl | 2019 |
Oleoyl glycine: interference with the aversive effects of acute naloxone-precipitated MWD, but not morphine reward, in male Sprague-Dawley rats.
Topics: Amygdala; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Glycine; Male; Mice; Morphi | 2019 |
Activation of glycine receptors in the lateral habenula rescues anxiety- and depression-like behaviors associated with alcohol withdrawal and reduces alcohol intake in rats.
Topics: Action Potentials; Alcohol Drinking; Animals; Anxiety; Behavior, Animal; Depression; Glycine; Habenu | 2019 |
Ghrelin receptor (GHS-R1A) antagonism suppresses both alcohol consumption and the alcohol deprivation effect in rats following long-term voluntary alcohol consumption.
Topics: Administration, Oral; Alcohol Drinking; Alcoholism; Animals; CpG Islands; DNA Methylation; Gene Expr | 2013 |
A protein synthesis-dependent mechanism sustains calcium-permeable AMPA receptor transmission in nucleus accumbens synapses during withdrawal from cocaine self-administration.
Topics: Animals; Benzoates; Calcium; Cocaine-Related Disorders; Cycloheximide; Excitatory Amino Acid Antagon | 2014 |
Cocaine Withdrawal Impairs mGluR5-Dependent Long-Term Depression in Nucleus Accumbens Shell Neurons of Both Direct and Indirect Pathways.
Topics: Animals; Benzamides; Chromones; Cocaine; Cocaine-Related Disorders; Dopaminergic Neurons; Excitatory | 2015 |
Cannabinoid-induced increase in relapse-like drinking is prevented by the blockade of the glycine-binding site of N-methyl-D-aspartate receptors.
Topics: Alcohol Drinking; Alcoholism; Animals; Benzoxazines; Binding Sites; Cannabinoids; Conditioning, Oper | 2009 |
Dopamine-induced plasticity, phospholipase D (PLD) activity and cocaine-cue behavior depend on PLD-linked metabotropic glutamate receptors in amygdala.
Topics: Amygdala; Animals; Behavior, Animal; Benzazepines; Cocaine; Conditioning, Psychological; Cues; Cyclo | 2011 |
Effects of glycine, beta-alanine and diazepam upon morphine-tolerant-dependent mice.
Topics: Alanine; Analgesia; Animals; beta-Alanine; Diazepam; Drug Interactions; Drug Tolerance; Female; Glyc | 1980 |
Elevation of erythrocyte glycine levels during lithium treatment of affective disorders.
Topics: Adult; Amino Acids; Bipolar Disorder; Depressive Disorder; Dose-Response Relationship, Drug; Erythro | 1982 |
Allosteric regulation of the N-methyl-D-aspartate receptor-linked ion channel complex and effects of ethanol in ethanol-withdrawal seizure-prone and -resistant mice.
Topics: Allosteric Regulation; Animals; Cerebral Cortex; Dizocilpine Maleate; Ethanol; Genetic Predispositio | 1995 |
Effect of activity at metabotropic, as well as ionotropic (NMDA), glutamate receptors on morphine dependence.
Topics: Alanine; Animals; Anti-Anxiety Agents; Behavior, Animal; Benzoates; Benzodiazepines; Dizocilpine Mal | 1994 |
Effect of morphine tolerance and abstinence on the binding of [3H]MK-801 to brain regions and spinal cord of the rat.
Topics: Animals; Brain; Dizocilpine Maleate; Down-Regulation; Drug Tolerance; Glutamates; Glutamic Acid; Gly | 1994 |
Excitatory amino acid receptor antagonists and naloxone-precipitated withdrawal syndrome in morphine-dependent mice.
Topics: Animals; Behavior, Animal; Dizocilpine Maleate; Glycine; Kynurenic Acid; Male; Mice; Morphine Depend | 1993 |
Spinal amino acid release and precipitated withdrawal in rats chronically infused with spinal morphine.
Topics: Amino Acids; Animals; Clonidine; Dizocilpine Maleate; Glutamic Acid; Glycine; Injections, Spinal; Ma | 1996 |
Novel structure having antagonist actions at both the glycine site of the N-methyl-D-aspartate receptor and neuronal voltage-sensitive sodium channels: biochemical, electrophysiological, and behavioral characterization.
Topics: Animals; Anti-Anxiety Agents; Ataxia; Behavior, Animal; Binding Sites; Binding, Competitive; Cells, | 2000 |
Brain glycine levels in triazolam-treated albino rats.
Topics: Animals; Anti-Anxiety Agents; Brain; Brain Chemistry; Dose-Response Relationship, Drug; Drug Adminis | 2001 |
Antagonism of the enhanced susceptibility to audiogenic seizures during alcohol withdrawal in the rat by gamma-aminobutyric acid (GABA) and "GABA-mimetic" agents.
Topics: 4-Aminobutyrate Transaminase; Acoustic Stimulation; Alcoholism; Aminobutyrates; Animals; Binding, Co | 1979 |
Effects of serine on morphine-dependent mice.
Topics: Animals; Brain; Drug Tolerance; Glycine; Humans; Male; Mice; Morphine Dependence; Nalorphine; Serine | 1976 |
NMDA receptors in mice bred to be prone or resistant to ethanol withdrawal seizures.
Topics: Animals; Brain; Cerebral Cortex; Dizocilpine Maleate; Drug Resistance; Ethanol; Glycine; Hippocampus | 1990 |
[Effect of glycine on chronic morphinism].
Topics: Aggression; Animals; Disease Models, Animal; Drug Synergism; Glycine; Humans; Mice; Morphine Depende | 1974 |