glycine and Diseases, Metabolic studies

Research Excerpts

Excerpt	Relevance	Reference
"The metabolic signature associated with obesity is characterized by a decrease in plasma glycine concentration, a feature closely associated with insulin resistance and highly predictive of the risk of developing chronic metabolic diseases."	9.41	Alterations in glycine metabolism in obesity and chronic metabolic diseases - an update on new advances. ( Alves, A; Morio, B, 2023)
"We tested whether glutathione deficiency occurs because of diminished synthesis and contributes to oxidative stress in aging and whether stimulating glutathione synthesis with its precursors cysteine and glycine could alleviate oxidative stress."	9.15	Deficient synthesis of glutathione underlies oxidative stress in aging and can be corrected by dietary cysteine and glycine supplementation. ( Balasubramanyam, A; Guthikonda, AP; Jahoor, F; Patel, SG; Reid, M; Sekhar, RV; Taffet, GE, 2011)
"A range of inborn metabolic diseases result in abnormal accumulation of acylglycines in body fluids."	7.78	Detection of acylglycines in urine by 1H and 13C NMR for the diagnosis of inborn metabolic diseases. ( Gryff-Keller, A; Kraska-Dziadecka, A; Kubica, D, 2012)
"The metabolic signature associated with obesity is characterized by a decrease in plasma glycine concentration, a feature closely associated with insulin resistance and highly predictive of the risk of developing chronic metabolic diseases."	5.41	Alterations in glycine metabolism in obesity and chronic metabolic diseases - an update on new advances. ( Alves, A; Morio, B, 2023)
"We tested whether glutathione deficiency occurs because of diminished synthesis and contributes to oxidative stress in aging and whether stimulating glutathione synthesis with its precursors cysteine and glycine could alleviate oxidative stress."	5.15	Deficient synthesis of glutathione underlies oxidative stress in aging and can be corrected by dietary cysteine and glycine supplementation. ( Balasubramanyam, A; Guthikonda, AP; Jahoor, F; Patel, SG; Reid, M; Sekhar, RV; Taffet, GE, 2011)
"A range of inborn metabolic diseases result in abnormal accumulation of acylglycines in body fluids."	3.78	Detection of acylglycines in urine by 1H and 13C NMR for the diagnosis of inborn metabolic diseases. ( Gryff-Keller, A; Kraska-Dziadecka, A; Kubica, D, 2012)
"Glycine also has the property to enhance the quality of sleep and neurological functions."	2.55	Multifarious Beneficial Effect of Nonessential Amino Acid, Glycine: A Review. ( Begum, PS; Rajagopal, S; Razak, MA; Viswanath, B, 2017)

Timeframe	Studies, this research(%)	All Research%
pre-1990	31 (63.27)	18.7374
1990's	2 (4.08)	18.2507
2000's	3 (6.12)	29.6817
2010's	9 (18.37)	24.3611
2020's	4 (8.16)	2.80

Authors	Studies
Gan, Z	1
Zhang, M	1
Xie, D	1
Wu, X	1
Hong, C	1
Fu, J	1
Fan, L	1
Wang, S	1
Han, S	1
Alves, A	2
Morio, B	2
Wei, X	1
Jia, X	1
Liu, R	1
Zhang, S	1
Liu, S	1
An, J	1
Zhou, L	1
Zhang, Y	1
Mo, Y	1
Li, X	1
Ostojic, SM	3
Ratgeber, L	1
Olah, A	1
Betlehem, J	1
Acs, P	1
Razak, MA	1
Begum, PS	1
Viswanath, B	1
Rajagopal, S	1
Koopman, R	1
Caldow, MK	1
Ham, DJ	1
Lynch, GS	1
Vandenbeek, R	1
Khan, NP	1
Estall, JL	1
Trivic, T	1
Drid, P	1
Stajer, V	1
Vranes, M	2
Loncar, D	1
Zenic, N	1
Sekulic, D	1
Bassot, A	1
Bulteau, AL	1
Pirola, L	1
Downing, M	1
Manning, NJ	1
Dalton, RN	1
Krywawych, S	1
Oerton, J	1
Barger, AV	1
Campeau, NG	1
Port, JD	1
Renaud, DL	1
Sun, Q	1
O'Brien, WE	1
Sekhar, RV	1
Patel, SG	1
Guthikonda, AP	1
Reid, M	1
Balasubramanyam, A	1
Taffet, GE	1
Jahoor, F	1
Gryff-Keller, A	1
Kraska-Dziadecka, A	1
Kubica, D	1
Gross, M	1
Rötzer, E	1
Kölle, P	1
Mortier, W	1
Reichmann, H	1
Goebel, HH	1
Lochmüller, H	1
Pongratz, D	1
Mahnke-Zizelman, DK	1
Sabina, RL	1
SZEINBERG, A	1
ADAM, A	1
RAMOT, B	1
SHEBA, C	1
MYERS, F	1
YAMANAKA, M	1
ISHII, K	1
ODA, T	1
WOOLF, LI	1
DIEHL, JF	1
RIDDELL, WM	1
TADA, K	2
YOSHIDA, T	2
MORIKAWA, T	1
MINAKAWA, A	1
WADA, Y	2
ANDO, T	1
SHIMURA, K	1
ZETTERSTROEM, R	1
EFRON, ML	1
YOUNG, D	1
MOSER, HW	1
MACCREADY, RA	1
MILNE, MD	1
HOCKADAY, TD	1
CLAYTON, JE	1
FREDERICK, EW	1
SMITH, LH	1
LATHE, GH	1
Gerner, EW	1
Hughes, SM	1
Oberley, TD	1
Gilbert, EF	1
Viseskul, C	1
Arya, S	1
Mertz, DP	1
Kamoun, P	1
Parvy, P	1
Debray-Ritzen, P	1
de Graciansky, P	1
Larrégue, M	1
Martinet, C	1
Caspary, WF	1
Libert, R	1
Hermans, D	1
Draye, JP	1
Van Hoof, F	1
Sokal, E	1
de Hoffmann, E	1
McDonald, JW	1
Johnston, MV	1
Turnbull, DM	1
Bartlett, K	1
Eyre, JA	1
Gardner-Medwin, D	1
Johnson, MA	1
Fisher, J	1
Watmough, NJ	1
Eldjarn, L	2
Jellum, E	2
Stokke, O	2
Takada, G	1
Omura, K	1
Lawson, AM	1
Chalmers, RA	1
Watts, RW	2
Valman, HB	1
Oberholzer, VG	1
Palmer, T	1
Admirand, WH	1
Gaull, GE	1
Morrow, G	1
Barness, LA	1
Perry, TL	1
Bunting, R	1
Tischler, B	1
Hansen, S	1
Diamond, S	1
Weppler, VC	1
Matthews, DM	1
Schlange, H	1
Von Berg, W	1
Kaplan, D	1
Diamond, H	1
Wallace, SL	1
Halberstam, D	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
The Effects of Glycine on Atherosclerosis and Metabolic Syndrome-related Parameters: A Clinical and Ex-vivo Study.[NCT03850314]	Phase 2/Phase 3	50 participants (Anticipated)	Interventional	2019-03-31	Not yet recruiting
Central Nervous System Uptake of Intranasal Glutathione in Parkinson's Disease[NCT02324426]	Phase 1	15 participants (Actual)	Interventional	2014-12-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Glycinergic Signaling in Macrophages and Its Application in Macrophage-Associated Diseases. Frontiers in immunology, 2021, Volume: 12 Topics: Animals; Colitis; Glycine; Humans; Macrophages; Metabolic Diseases; MicroRNAs; Neoplasms; Reperfusio	2021
Alterations in glycine metabolism in obesity and chronic metabolic diseases - an update on new advances. Current opinion in clinical nutrition and metabolic care, 2023, 01-01, Volume: 26, Issue:1 Topics: Amino Acids, Branched-Chain; Diet; Glycine; Humans; Insulin Resistance; Metabolic Diseases; Obesity	2023
Guanidinoacetic acid deficiency: a new entity in clinical medicine? International journal of medical sciences, 2020, Volume: 17, Issue:16 Topics: Creatine; Energy Metabolism; Glycine; Humans; Metabolic Diseases	2020
Multifarious Beneficial Effect of Nonessential Amino Acid, Glycine: A Review. Oxidative medicine and cellular longevity, 2017, Volume: 2017 Topics: Animals; Cardiovascular Diseases; Choline; Dietary Supplements; Glycine; Humans; Kidney; Liver; Meta	2017
Glycine metabolism in skeletal muscle: implications for metabolic homeostasis. Current opinion in clinical nutrition and metabolic care, 2017, Volume: 20, Issue:4 Topics: Animals; Anti-Inflammatory Agents; Dietary Supplements; Glycine; Homeostasis; Humans; Metabolic Dise	2017
Linking Metabolic Disease With the PGC-1α Gly482Ser Polymorphism. Endocrinology, 2018, 02-01, Volume: 159, Issue:2 Topics: Amino Acid Substitution; Diabetes Mellitus, Type 2; Genetic Linkage; Genetic Predisposition to Disea	2018
Glycine Metabolism and Its Alterations in Obesity and Metabolic Diseases. Nutrients, 2019, Jun-16, Volume: 11, Issue:6 Topics: Biological Availability; Diabetes Mellitus, Type 2; Diet; Gastrointestinal Microbiome; Glycine; Huma	2019
[RENAL TUBULAR DISEASES, WITH SPECIAL REFERENCE TO AMINOACIDURIA]. Recenti progressi in medicina, 1964, Volume: 36 Topics: Cystinosis; Cystinuria; Galactosemias; Genetics, Medical; Glycine; Hepatolenticular Degeneration; Hu	1964
PRIMARY HYPEROXALURIA. Medicine, 1964, Volume: 43 Topics: Adolescent; Ascorbic Acid; Biochemical Phenomena; Biochemistry; Child; Classification; Diet; Genetic	1964
DISORDERS OF BILIRUBIN METABOLISM. Clinical chemistry, 1965, Volume: 11 Topics: Bilirubin; Coloring Agents; Glucosyltransferases; Glucuronates; Glycine; Humans; Hyperbilirubinemia;	1965
[Theory of pathogenesis in primary hyperuricamia]. Medizinische Klinik, 1975, Jul-11, Volume: 70, Issue:28-29 Topics: Adenosine Monophosphate; Adult; Child; Female; Glucosephosphates; Glycine; Gout; Humans; Kidney; Les	1975
Oxaluria in patients with ileal dysfunction. Nutrition reviews, 1973, Volume: 31, Issue:10 Topics: Carbon Radioisotopes; Crohn Disease; Diet Therapy; Glycine; Humans; Ileum; Intestinal Absorption; In	1973

Article	Year
Effects of Guanidinoacetic Acid Loading on Biomarkers of Cardiometabolic Risk and Inflammation. Annals of nutrition & metabolism, 2018, Volume: 72, Issue:1 Topics: Biomarkers; C-Reactive Protein; Cardiovascular Diseases; Cholesterol, HDL; Dietary Supplements; Fema	2018
Deficient synthesis of glutathione underlies oxidative stress in aging and can be corrected by dietary cysteine and glycine supplementation. The American journal of clinical nutrition, 2011, Volume: 94, Issue:3 Topics: Adult; Age Factors; Aged; Aging; Cysteine; Dietary Supplements; Erythrocytes; F2-Isoprostanes; Gluta	2011

glycine and Diseases, Metabolic

Research Excerpts

Research

Studies (49)

Authors

Clinical Trials (2)

Trial Overview

Reviews

Trials

Other Studies

Article	Year
Metabolic pathway analysis of hyperuricaemia patients with hyperlipidaemia based on high-throughput mass spectrometry: a case‒control study. Lipids in health and disease, 2022, Dec-31, Volume: 21, Issue:1 Topics: Alanine; Aspartic Acid; Biomarkers; Case-Control Studies; Glycine; Humans; Hyperlipidemias; Hyperuri	2022
Guanidinoacetic Acid and Creatine are Associated with Cardiometabolic Risk Factors in Healthy Men and Women: A Cross-Sectional Study. Nutrients, 2018, Jan-13, Volume: 10, Issue:1 Topics: Adolescent; Adult; Body Mass Index; C-Reactive Protein; Cardiovascular Diseases; Cholesterol; Chroma	2018
Detection of urinary hexanoylglycine in the diagnosis of MCAD deficiency from newborn screening. Journal of inherited metabolic disease, 2008, Volume: 31, Issue:4 Topics: Acyl-CoA Dehydrogenase; Clinical Laboratory Techniques; Glycine; Humans; Infant, Newborn; Metabolic	2008
MRS is the test of choice for detecting and monitoring disorders of creatine metabolism. Pediatric neurology, 2009, Volume: 40, Issue:5 Topics: Brain; Brain Chemistry; Creatine; Developmental Disabilities; Glycine; Humans; Infant; Magnetic Reso	2009
Diagnosis of creatine metabolism disorders by determining creatine and guanidinoacetate in plasma and urine. Methods in molecular biology (Clifton, N.J.), 2010, Volume: 603 Topics: Amidinotransferases; Chromatography, High Pressure Liquid; Creatine; Glycine; Guanidinoacetate N-Met	2010
Detection of acylglycines in urine by 1H and 13C NMR for the diagnosis of inborn metabolic diseases. Acta biochimica Polonica, 2012, Volume: 59, Issue:4 Topics: Carbon Isotopes; Female; Glycine; Humans; Hydrogen; Magnetic Resonance Spectroscopy; Metabolic Disea	2012
A G468-T AMPD1 mutant allele contributes to the high incidence of myoadenylate deaminase deficiency in the Caucasian population. Neuromuscular disorders : NMD, 2002, Volume: 12, Issue:6 Topics: Alleles; AMP Deaminase; Blotting, Western; DNA Probes; DNA, Complementary; Electromyography; Genotyp	2002
The incorporation of isotopically labelled glycine into glutathione of erythrocytes with glucose-6-phosphate dehydrogenase deficiency. Biochimica et biophysica acta, 1959, Volume: 36 Topics: Biochemical Phenomena; Erythrocytes; Glucosephosphate Dehydrogenase Deficiency; Glutathione; Glycine	1959
Studies on the determination of the human glycine pool. Clinica chimica acta; international journal of clinical chemistry, 1959, Volume: 4 Topics: Glycine; Humans; Liver Diseases; Metabolic Diseases	1959
Glycinuria. Bulletin der Schweizerischen Akademie der Medizinischen Wissenschaften, 1962, Volume: 17 Topics: Body Fluids; Glycine; Humans; Kidney Diseases; Metabolic Diseases; Urinary Calculi	1962
Incorporation of labeled glycine into erythrocyte glutathione of rabbits; effect of nutritional muscular dystrophy. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1963, Volume: 112 Topics: Animals; Erythrocytes; Glutathione; Glycine; Metabolic Diseases; Muscular Dystrophies; Rabbits; Vita	1963
IDIOPATHIC HYPERGLYCINEMIA (THE FIRST CASE IN JAPAN). The Tohoku journal of experimental medicine, 1963, Aug-25, Volume: 80 Topics: Amino Acid Metabolism, Inborn Errors; Blood Chemical Analysis; Chromatography; Epidemiology; Glycine	1963
TYROSINOSIS. Annals of the New York Academy of Sciences, 1963, Dec-30, Volume: 111 Topics: Alanine; Amino Acid Metabolism, Inborn Errors; Blood Chemical Analysis; Child; Genetics, Medical; Gl	1963
A SIMPLE CHROMATOGRAPHIC SCREENING TEST FOR THE DETECTION OF DISORDERS OF AMINO ACID METABOLISM. A TECHNIC USING WHOLE BLOOD OR URINE COLLECTED ON FILTER PAPER. The New England journal of medicine, 1964, Jun-25, Volume: 270 Topics: Amino Acid Metabolism, Inborn Errors; Amino Acids; Blood Chemical Analysis; Chromatography; Citrulli	1964
Floppy eyelid with hyperglycinemia. American journal of ophthalmology, 1984, Volume: 98, Issue:5 Topics: Adult; Eyelid Diseases; Glycine; Humans; Male; Metabolic Diseases	1984
Culture of human glomeruli from patients with metabolic or genetic diseases. Archives of pathology & laboratory medicine, 1981, Volume: 105, Issue:5 Topics: Adult; Cells, Cultured; Child, Preschool; Glycine; Humans; Kidney Diseases; Kidney Glomerulus; Lipof	1981
[Hyperglycinuria induced by n-dipropylacetate. Possible model of propionic acidemia]. La Nouvelle presse medicale, 1977, Jun-11, Volume: 6, Issue:24 Topics: Child; Child, Preschool; Glycine; Humans; Infant; Metabolic Diseases; Models, Biological; Propionate	1977
[Hyperuricemia and psoriasis]. Annales de dermatologie et de syphiligraphie, 1976, Volume: 103, Issue:5-6 Topics: Carbon Radioisotopes; Female; Glycine; Gout; Humans; Male; Metabolic Diseases; Psoriasis; Uric Acid	1976
[Acquired hyperoxaluria and nephrolithiasis in gastrointestinal diseases ("enteral" hyperoxaluria)]. Deutsche medizinische Wochenschrift (1946), 1975, Jul-11, Volume: 100, Issue:28 Topics: Carbon Radioisotopes; Gastrointestinal Diseases; Glycine; Glyoxylates; Humans; Intestinal Absorption	1975
Bile acids and conjugates identified in metabolic disorders by fast atom bombardment and tandem mass spectrometry. Clinical chemistry, 1991, Volume: 37, Issue:12 Topics: Adrenoleukodystrophy; Bile Acids and Salts; Glycine; Humans; Hydroxylation; Mass Spectrometry; Metab	1991
Nonketotic hyperglycinemia: pathophysiological role of NMDA-type excitatory amino acid receptors. Annals of neurology, 1990, Volume: 27, Issue:4 Topics: Glycine; Humans; Metabolic Diseases; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; S	1990
Lipid storage myopathy due to glutaric aciduria type II: treatment of a potentially fatal myopathy. Developmental medicine and child neurology, 1988, Volume: 30, Issue:5 Topics: Carnitine; Female; Glutarates; Glutaryl-CoA Dehydrogenase; Glycine; Humans; Infant; Lipid Metabolism	1988
Application of gas chromatography-mass spectrometry in routine and research in clinical chemistry. Journal of chromatography, 1974, Apr-24, Volume: 91 Topics: Acidosis; Adult; Body Fluids; Carbon Dioxide; Chemistry, Clinical; Chromatography, Gas; Clinical Lab	1974
Hyperglycinemia associated with hyperammonemia: in vitro glycine cleavage in liver. Pediatric research, 1972, Volume: 6, Issue:7 Topics: Amino Acid Metabolism, Inborn Errors; Ammonia; Biopsy; Glycine; Humans; In Vitro Techniques; Infant;	1972
Comparative GC/MS studies on the urinary acidic metabolites in beta-methylcrotonylglycinuria propionic acidaemia and methylmalonic acidaemia. Zeitschrift fur klinische Chemie und klinische Biochemie, 1974, Volume: 12, Issue:5 Topics: Butyrates; Carboxylic Acids; Chromatography, Gas; Coenzyme A; Crotonates; Glycine; Humans; Malonates	1974
Combined use of gas chromatography, mass spectrometry, and computer in diagnosis and studies of metabolic disorders. Clinical chemistry, 1972, Volume: 18, Issue:8 Topics: Adult; Biopsy; Blood Chemical Analysis; Butyrates; Carbon Dioxide; Chemistry, Clinical; Chromatograp	1972
Hyperoxaluria after resection of ileum in childhood. Archives of disease in childhood, 1974, Volume: 49, Issue:3 Topics: Adolescent; Age Factors; Bile; Child; Child, Preschool; Glycine; Humans; Ileum; Infant; Infant, Newb	1974
Hyperoxaluria and bowel disease. The New England journal of medicine, 1972, Jun-29, Volume: 286, Issue:26 Topics: Bile Acids and Salts; Carbon Isotopes; Glycine; Glycolates; Humans; Ileum; Intestinal Diseases; Kidn	1972
Homocystinuria, vitamin B 6 , and folate: metabolic interrelationships and clinical significance. The Journal of pediatrics, 1972, Volume: 81, Issue:5 Topics: Alcohol Oxidoreductases; Cystathionine; Folic Acid; Glycine; Homocystine; Homocystinuria; Humans; L-	1972
Combined vitamin responsiveness in homocystinuria. The Journal of pediatrics, 1972, Volume: 81, Issue:5 Topics: Adolescent; Adult; Amino Acids; Child; Drug Synergism; Female; Folic Acid; Folic Acid Deficiency; Gl	1972
Unrecognized maternal biochemical disease: an uncommon cause of mental retardation in children. Journal of mental deficiency research, 1970, Volume: 14, Issue:1 Topics: Child; Cystinuria; Female; Glycine; Humans; Infant, Newborn; Intellectual Disability; Lysine; Metabo	1970
Experimental approach in chemical pathology. British medical journal, 1971, Sep-18, Volume: 3, Issue:5776 Topics: Adult; Amblyopia; Animals; Biological Transport; Cystinuria; Dipeptides; Female; Glycine; Hartnup Di	1971
[Autism in childhood--a metabolic disorder?]. Monatsschrift fur Kinderheilkunde, 1967, Volume: 115, Issue:4 Topics: Autistic Disorder; Child; Chromatography, Thin Layer; Glycine; Humans; Metabolic Diseases; Schizophr	1967
Amino acid excretion in primary hyperuricaemia. Annals of the rheumatic diseases, 1969, Volume: 28, Issue:2 Topics: Amino Acids; Arginine; Biological Transport, Active; Glomerular Filtration Rate; Glycine; Kidney; Ki	1969
Hyperuricaemia: some biochemical aspects. Proceedings of the Royal Society of Medicine, 1969, Volume: 62, Issue:8 Topics: Adenine; Carbon Isotopes; Glycine; Humans; In Vitro Techniques; Intellectual Disability; Metabolic D	1969