glycine has been researched along with Depressive Disorder, Treatment-Resistant in 1 studies
Depressive Disorder, Treatment-Resistant: Failure to respond to two or more trials of antidepressant monotherapy or failure to respond to four or more trials of different antidepressant therapies. (Campbell's Psychiatric Dictionary, 9th ed.)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (100.00) | 2.80 |
| Authors | Studies |
|---|---|
| Park, LT | 1 |
| Kadriu, B | 1 |
| Gould, TD | 1 |
| Zanos, P | 1 |
| Greenstein, D | 1 |
| Evans, JW | 1 |
| Yuan, P | 1 |
| Farmer, CA | 1 |
| Oppenheimer, M | 1 |
| George, JM | 1 |
| Adeojo, LW | 1 |
| Snodgrass, HR | 1 |
| Smith, MA | 1 |
| Henter, ID | 1 |
| Machado-Vieira, R | 1 |
| Mannes, AJ | 1 |
| Zarate, CA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| An Investigation of the Antidepressant Effects of the Glycine Receptor Antagonist AV 101 (4-chlorokynurenine) in Major Depressive Disorder[NCT02484456] | Phase 2 | 22 participants (Actual) | Interventional | 2015-10-14 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The Beck Depression Inventory (BDI) is a 21-item measure of depression with each question on a 4-point scale ranging from 0=minimal to 3 = more severe (full list score values = 0,1,2,3). Total scores are a sum of individual items. The minimal depression = 0-13, mild depression = 14-19, moderate depression = 20-28, and severe depression = 29-63. The maximum score being 63 and the minimum possible score = 0. (NCT02484456)
Timeframe: Post Dose Day 0
| Intervention | score on a scale (Mean) |
|---|---|
| AV 101 (4-chlorokynurenine) | 25.35 |
| Placebo | 25.79 |
The Beck Depression Inventory (BDI) is a 21-item measure of depression with each question on a 4-point scale ranging from 0=minimal to 3 = more severe (full list score values = 0,1,2,3). Total scores are a sum of individual items. The minimal depression = 0-13, mild depression = 14-19, moderate depression = 20-28, and severe depression = 29-63. The maximum score being 63 and the minimum possible score = 0. (NCT02484456)
Timeframe: Post Dose Day 1
| Intervention | score on a scale (Mean) |
|---|---|
| AV 101 (4-chlorokynurenine) | 24.76 |
| Placebo | 24.75 |
The Beck Depression Inventory (BDI) is a 21-item measure of depression with each question on a 4-point scale ranging from 0=minimal to 3 = more severe (full list score values = 0,1,2,3). Total scores are a sum of individual items. The minimal depression = 0-13, mild depression = 14-19, moderate depression = 20-28, and severe depression = 29-63. The maximum score being 63 and the minimum possible score = 0. (NCT02484456)
Timeframe: Post Dose Day 13
| Intervention | score on a scale (Mean) |
|---|---|
| AV 101 (4-chlorokynurenine) | 25.86 |
| Placebo | 23.84 |
The Beck Depression Inventory (BDI) is a 21-item measure of depression with each question on a 4-point scale ranging from 0=minimal to 3 = more severe (full list score values = 0,1,2,3). Total scores are a sum of individual items. The minimal depression = 0-13, mild depression = 14-19, moderate depression = 20-28, and severe depression = 29-63. The maximum score being 63 and the minimum possible score = 0. (NCT02484456)
Timeframe: Post Dose Day 2
| Intervention | score on a scale (Mean) |
|---|---|
| AV 101 (4-chlorokynurenine) | 25.88 |
| Placebo | 26.14 |
The Beck Depression Inventory (BDI) is a 21-item measure of depression with each question on a 4-point scale ranging from 0=minimal to 3 = more severe (full list score values = 0,1,2,3). Total scores are a sum of individual items. The minimal depression = 0-13, mild depression = 14-19, moderate depression = 20-28, and severe depression = 29-63. The maximum score being 63 and the minimum possible score = 0. (NCT02484456)
Timeframe: Post Dose Day 3
| Intervention | score on a scale (Mean) |
|---|---|
| AV 101 (4-chlorokynurenine) | 25.64 |
| Placebo | 24.64 |
The Beck Depression Inventory (BDI) is a 21-item measure of depression with each question on a 4-point scale ranging from 0=minimal to 3 = more severe (full list score values = 0,1,2,3). Total scores are a sum of individual items. The minimal depression = 0-13, mild depression = 14-19, moderate depression = 20-28, and severe depression = 29-63. The maximum score being 63 and the minimum possible score = 0. (NCT02484456)
Timeframe: Post Dose Day 7
| Intervention | score on a scale (Mean) |
|---|---|
| AV 101 (4-chlorokynurenine) | 25.82 |
| Placebo | 24.22 |
The Hamilton Anxiety Rating Scale (HAM-A) is a 14-item global measure of anxiety symptoms. Each item is scored on a scale of 0 (not present) to 4 (severe) (full score list = 0,1,2,3,4), with a total score range of 0-56 (0 = minimum score and 56 = maximum), where <17 indicates mild severity, 18-24 mild to moderate severity and 25-30 moderate to severe. Total scores are a sum of individual items. (NCT02484456)
Timeframe: Post Dose Day 0
| Intervention | score on a scale (Mean) |
|---|---|
| AV 101 (4-chlorokynurenine) | 15.71 |
| Placebo | 16.20 |
The Hamilton Anxiety Rating Scale (HAM-A) is a 14-item global measure of anxiety symptoms. Each item is scored on a scale of 0 (not present) to 4 (severe) (full score list = 0,1,2,3,4), with a total score range of 0-56 (0 = minimum score and 56 = maximum), where <17 indicates mild severity, 18-24 mild to moderate severity and 25-30 moderate to severe. Total scores are a sum of individual items. (NCT02484456)
Timeframe: Post Dose Day 1
| Intervention | score on a scale (Mean) |
|---|---|
| AV 101 (4-chlorokynurenine) | 17.30 |
| Placebo | 16.67 |
The Hamilton Anxiety Rating Scale (HAM-A) is a 14-item global measure of anxiety symptoms. Each item is scored on a scale of 0 (not present) to 4 (severe) (full score list = 0,1,2,3,4), with a total score range of 0-56 (0 = minimum score and 56 = maximum), where <17 indicates mild severity, 18-24 mild to moderate severity and 25-30 moderate to severe. Total scores are a sum of individual items. (NCT02484456)
Timeframe: Post Dose Day 13
| Intervention | score on a scale (Mean) |
|---|---|
| AV 101 (4-chlorokynurenine) | 18.33 |
| Placebo | 16.28 |
The Hamilton Anxiety Rating Scale (HAM-A) is a 14-item global measure of anxiety symptoms. Each item is scored on a scale of 0 (not present) to 4 (severe) (full score list = 0,1,2,3,4), with a total score range of 0-56 (0 = minimum score and 56 = maximum), where <17 indicates mild severity, 18-24 mild to moderate severity and 25-30 moderate to severe. Total scores are a sum of individual items. (NCT02484456)
Timeframe: Post Dose Day 2
| Intervention | score on a scale (Mean) |
|---|---|
| AV 101 (4-chlorokynurenine) | 17.83 |
| Placebo | 17.66 |
The Hamilton Anxiety Rating Scale (HAM-A) is a 14-item global measure of anxiety symptoms. Each item is scored on a scale of 0 (not present) to 4 (severe) (full score list = 0,1,2,3,4), with a total score range of 0-56 (0 = minimum score and 56 = maximum), where <17 indicates mild severity, 18-24 mild to moderate severity and 25-30 moderate to severe. Total scores are a sum of individual items. (NCT02484456)
Timeframe: Post Dose Day 3
| Intervention | score on a scale (Mean) |
|---|---|
| AV 101 (4-chlorokynurenine) | 16.48 |
| Placebo | 17.87 |
The Hamilton Anxiety Rating Scale (HAM-A) is a 14-item global measure of anxiety symptoms. Each item is scored on a scale of 0 (not present) to 4 (severe) (full score list = 0,1,2,3,4), with a total score range of 0-56 (0 = minimum score and 56 = maximum), where <17 indicates mild severity, 18-24 mild to moderate severity and 25-30 moderate to severe. Total scores are a sum of individual items. (NCT02484456)
Timeframe: Post Dose Day 7
| Intervention | score on a scale (Mean) |
|---|---|
| AV 101 (4-chlorokynurenine) | 18.42 |
| Placebo | 17.25 |
The Hamilton Depression Rating scale is a 17-item global measure of depressive symptoms on a 5-point scale ranging from 0 = not present to 4 = severe (full score values = 0,1,2,3,4). Some items rated on a scale of 0-2 (0, 1, 2) with 0 = not present to 2 = more severe. Total scores are a sum of the individual items. The maximum total score being 52 on the 17-point scale, and the minimum score being 0.Total scores of 0-7 are considered as being normal, 8-16 suggest mild depression, 17-23 moderate depression and scores over 24 are indicative of severe depression. (NCT02484456)
Timeframe: Post Dose Day 0
| Intervention | score on a scale (Mean) |
|---|---|
| AV 101 (4-chlorokynurenine) | 20.22 |
| Placebo | 20.56 |
The Hamilton Depression Rating scale is a 17-item global measure of depressive symptoms on a 5-point scale ranging from 0 = not present to 4 = severe (full score values = 0,1,2,3,4). Some items rated on a scale of 0-2 (0, 1, 2) with 0 = not present to 2 = more severe. Total scores are a sum of the individual items. The maximum total score being 52 on the 17-point scale, and the minimum score being 0.Total scores of 0-7 are considered as being normal, 8-16 suggest mild depression, 17-23 moderate depression and scores over 24 are indicative of severe depression. (NCT02484456)
Timeframe: Post Dose Day 1
| Intervention | score on a scale (Mean) |
|---|---|
| AV 101 (4-chlorokynurenine) | 20.22 |
| Placebo | 20.06 |
The Hamilton Depression Rating scale is a 17-item global measure of depressive symptoms on a 5-point scale ranging from 0 = not present to 4 = severe (full score values = 0,1,2,3,4). Some items rated on a scale of 0-2 (0, 1, 2) with 0 = not present to 2 = more severe. Total scores are a sum of the individual items. The maximum total score being 52 on the 17-point scale, and the minimum score being 0.Total scores of 0-7 are considered as being normal, 8-16 suggest mild depression, 17-23 moderate depression and scores over 24 are indicative of severe depression. (NCT02484456)
Timeframe: Post Dose Day 13
| Intervention | score on a scale (Mean) |
|---|---|
| AV 101 (4-chlorokynurenine) | 21.52 |
| Placebo | 19.69 |
The Hamilton Depression Rating scale is a 17-item global measure of depressive symptoms on a 5-point scale ranging from 0 = not present to 4 = severe (full score values = 0,1,2,3,4). Some items rated on a scale of 0-2 (0, 1, 2) with 0 = not present to 2 = more severe. Total scores are a sum of the individual items. The maximum total score being 52 on the 17-point scale, and the minimum score being 0.Total scores of 0-7 are considered as being normal, 8-16 suggest mild depression, 17-23 moderate depression and scores over 24 are indicative of severe depression. (NCT02484456)
Timeframe: Post Dose Day 2
| Intervention | score on a scale (Mean) |
|---|---|
| AV 101 (4-chlorokynurenine) | 20.75 |
| Placebo | 20.41 |
The Hamilton Depression Rating scale is a 17-item global measure of depressive symptoms on a 5-point scale ranging from 0 = not present to 4 = severe (full score values = 0,1,2,3,4). Some items rated on a scale of 0-2 (0, 1, 2) with 0 = not present to 2 = more severe. Total scores are a sum of the individual items. The maximum total score being 52 on the 17-point scale, and the minimum score being 0.Total scores of 0-7 are considered as being normal, 8-16 suggest mild depression, 17-23 moderate depression and scores over 24 are indicative of severe depression. (NCT02484456)
Timeframe: Post Dose Day 3
| Intervention | score on a scale (Mean) |
|---|---|
| AV 101 (4-chlorokynurenine) | 19.51 |
| Placebo | 20.74 |
The Hamilton Depression Rating scale is a 17-item global measure of depressive symptoms on a 5-point scale ranging from 0 = not present to 4 = severe (full score values = 0,1,2,3,4). Some items rated on a scale of 0-2 (0, 1, 2) with 0 = not present to 2 = more severe. Total scores are a sum of the individual items. The maximum total score being 52 on the 17-point scale, and the minimum score being 0.Total scores of 0-7 are considered as being normal, 8-16 suggest mild depression, 17-23 moderate depression and scores over 24 are indicative of severe depression. (NCT02484456)
Timeframe: Post Dose Day 7
| Intervention | score on a scale (Mean) |
|---|---|
| AV 101 (4-chlorokynurenine) | 21.28 |
| Placebo | 20.43 |
"The Montgomery-Asberg Depression Rating Scale (MADRS) is a 10-item global measure evaluating core symptoms of depression. Questions concern how the patient has felt over the past week. Each item is rated on a scale from 0 to 6, with 0 being normal/not present and 6 being extreme (full score list = 0,1,2,3,4,5,6). Maximum score = 60, minimum score = 0. Total scores are a sum of the individual items." (NCT02484456)
Timeframe: Post Dose Day 0
| Intervention | score on a scale (Mean) |
|---|---|
| AV 101 (4-chlorokynurenine) | 29.28 |
| Placebo | 29.48 |
"The Montgomery-Asberg Depression Rating Scale (MADRS) is a 10-item global measure evaluating core symptoms of depression. Questions concern how the patient has felt over the past week. Each item is rated on a scale from 0 to 6, with 0 being normal/not present and 6 being extreme (full score list = 0,1,2,3,4,5,6). Maximum score = 60, minimum score = 0. Total scores are a sum of the individual items." (NCT02484456)
Timeframe: Post Dose Day 1
| Intervention | score on a scale (Mean) |
|---|---|
| AV 101 (4-chlorokynurenine) | 28.75 |
| Placebo | 28.79 |
"The Montgomery-Asberg Depression Rating Scale (MADRS) is a 10-item global measure evaluating core symptoms of depression. Questions concern how the patient has felt over the past week. Each item is rated on a scale from 0 to 6, with 0 being normal/not present and 6 being extreme (full score list = 0,1,2,3,4,5,6). Maximum score = 60, minimum score = 0. Total scores are a sum of the individual items." (NCT02484456)
Timeframe: Post Dose Day 13
| Intervention | score on a scale (Mean) |
|---|---|
| AV 101 (4-chlorokynurenine) | 29.70 |
| Placebo | 27.06 |
"The Montgomery-Asberg Depression Rating Scale (MADRS) is a 10-item global measure evaluating core symptoms of depression. Questions concern how the patient has felt over the past week. Each item is rated on a scale from 0 to 6, with 0 being normal/not present and 6 being extreme (full score list = 0,1,2,3,4,5,6). Maximum score = 60, minimum score = 0. Total scores are a sum of the individual items." (NCT02484456)
Timeframe: Post Dose Day 2
| Intervention | score on a scale (Mean) |
|---|---|
| AV 101 (4-chlorokynurenine) | 29.51 |
| Placebo | 29.84 |
"The Montgomery-Asberg Depression Rating Scale (MADRS) is a 10-item global measure evaluating core symptoms of depression. Questions concern how the patient has felt over the past week. Each item is rated on a scale from 0 to 6, with 0 being normal/not present and 6 being extreme (full score list = 0,1,2,3,4,5,6). Maximum score = 60, minimum score = 0. Total scores are a sum of the individual items." (NCT02484456)
Timeframe: Post Dose Day 3
| Intervention | score on a scale (Mean) |
|---|---|
| AV 101 (4-chlorokynurenine) | 29.85 |
| Placebo | 30.81 |
"The Montgomery-Asberg Depression Rating Scale (MADRS) is a 10-item global measure evaluating core symptoms of depression. Questions concern how the patient has felt over the past week. Each item is rated on a scale from 0 to 6, with 0 being normal/not present and 6 being extreme (full score list = 0,1,2,3,4,5,6). Maximum score = 60, minimum score = 0. Total scores are a sum of the individual items." (NCT02484456)
Timeframe: Post Dose Day 7
| Intervention | score on a scale (Mean) |
|---|---|
| AV 101 (4-chlorokynurenine) | 30.45 |
| Placebo | 28.64 |
1 trial available for glycine and Depressive Disorder, Treatment-Resistant
| Article | Year |
|---|---|
A Randomized Trial of the N-Methyl-d-Aspartate Receptor Glycine Site Antagonist Prodrug 4-Chlorokynurenine in Treatment-Resistant Depression.
Topics: Adolescent; Adult; Aged; Animals; Antidepressive Agents; Brain; Brain Chemistry; Cross-Over Studies; | 2020 |