glycine and Deficiency, Pyridoxine studies

Research Excerpts

Excerpt	Relevance	Reference
"An asphyxiated neonate with pyridoxine-dependent seizures and associated transient nonketotic hyperglycinemia is reported."	7.70	Transient nonketotic hyperglycinemia in an asphyxiated patient with pyridoxine-dependent seizures. ( Goto, K; Inutsuka, M; Izumi, T; Maeda, T, 2000)
"An asphyxiated neonate with pyridoxine-dependent seizures and associated transient nonketotic hyperglycinemia is reported."	3.70	Transient nonketotic hyperglycinemia in an asphyxiated patient with pyridoxine-dependent seizures. ( Goto, K; Inutsuka, M; Izumi, T; Maeda, T, 2000)
"The pathogenesis of vitamin B6 deficiency is largely unknown."	1.46	Vitamin B6 is essential for serine de novo biosynthesis. ( Burgering, B; Gerrits, J; Jans, JJ; Pras-Raves, ML; Prinsen, H; Ramos, RJ; van der Ham, M; Verhoeven-Duif, NM; Willemsen, M, 2017)
"Glycine is a precursor of purines, protein, glutathione, and 1-carbon units as 5,10-methylenetetrahydrofolate."	1.35	Moderate dietary vitamin B-6 restriction raises plasma glycine and cystathionine concentrations while minimally affecting the rates of glycine turnover and glycine cleavage in healthy men and women. ( Fredriksen, A; Gilbert, LR; Gregory, JF; Keeling, C; Lamers, Y; Meyer, K; Newgard, CB; Quinlivan, EP; Ralat, M; Stacpoole, PW; Stevens, RD; Ueland, PM; Williamson, J, 2009)
"The effect of pyridoxine deficiency on cholesterol catabolism was studied in rats."	1.26	Stimulation of cholesterol metabolism in pyridoxine-deficient rats. ( Iwami, T; Okada, M, 1982)

Research

Studies (43)

Authors

Clinical Trials (2)

Trial Overview

Trial Outcomes

Fasting Plasma Cystathionine Concentration

Timeframe	Studies, this research(%)	All Research%
pre-1990	37 (86.05)	18.7374
1990's	1 (2.33)	18.2507
2000's	3 (6.98)	29.6817
2010's	2 (4.65)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Ramos, RJ	1
Pras-Raves, ML	1
Gerrits, J	1
van der Ham, M	1
Willemsen, M	1
Prinsen, H	1
Burgering, B	1
Jans, JJ	1
Verhoeven-Duif, NM	1
Rios-Avila, L	1
Coats, B	1
Ralat, M	2
Chi, YY	1
Midttun, Ø	1
Ueland, PM	2
Stacpoole, PW	2
Gregory, JF	3
Lamers, Y	1
Williamson, J	1
Quinlivan, EP	1
Gilbert, LR	1
Keeling, C	1
Stevens, RD	1
Newgard, CB	1
Meyer, K	1
Fredriksen, A	1
Nijhout, HF	1
Fitzpatrick, C	1
Cho, E	1
Lamers, KY	1
Ulrich, CM	1
Reed, MC	1
BEREZOV, TT	1
BERGERET, B	2
CHATAGNER, F	2
GERSHOFF, SN	7
FARAGALLA, FF	1
GANTI, Y	1
SHANMUGASUNDARAM, ER	1
Swendseid, ME	1
Villalobos, J	1
Friedrich, B	1
HOCKADAY, TD	2
CLAYTON, JE	2
FREDERICK, EW	1
SMITH, LH	3
EFRON, ML	1
RUNYAN, TJ	2
WINNICK, T	1
PETERSON, EA	1
GREENBERG, DM	1
Tews, JK	2
Lovell, RA	1
Williams, HE	1
Wilson, M	1
Nath, R	1
Thind, SK	1
Murthy, MS	1
Talwar, HS	1
Farooqui, S	1
Bonkowsky, HL	1
Schady, W	1
Aboaysha, AM	1
Kratzer, FH	1
Ribaya, JD	3
Iwami, T	1
Okada, M	2
Maeda, T	1
Inutsuka, M	1
Goto, K	1
Izumi, T	1
Thomas, DW	1
Hannett, B	1
Chalmers, A	1
Rofe, AM	1
Edwards, JB	1
Edwards, RG	1
Ota, K	1
Guilarte, TR	2
Wolfson, M	1
Kopple, JD	1
Wohllebe, W	1
Paul, I	1
Liao, LL	1
Richardson, KE	3
Armstrong, MD	1
Stave, U	1
Suzuki, K	1
Sifri, M	1
Daghir, NJ	1
Asmar, JA	1
Asatoor, AM	1
Chadha, AK	1
Dawson, IM	1
Milne, MD	1
Prosser, DI	1
Hauschildt, S	1
Rudolph, R	1
Feldheim, W	1
Avery, MD	1
Lupien, PJ	1
Park, YK	1
Linkswiler, H	1
Gill, TJ	1
Simonian, SJ	1
Steinberg, AI	1
Hsu, JM	1
Buddemeyer, E	1
Chow, BF	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Vitamin B6 Effects on One-Carbon Metabolism[NCT01128244]	Phase 2/Phase 3	13 participants (Actual)	Interventional	2010-04-30	Completed
Vitamin B6 Dependence of One-Carbon Metabolism[NCT00877812]		45 participants (Actual)	Interventional	2008-01-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

For all subjects, the concentration of plasma cystathionine in fasting blood samples taken before and after the supplementation period will provide a functional measure of vitamin B6 nutritional status. (NCT01128244)
Timeframe: Fasting blood samples will be taken at baseline and after 28 days of vitamin B6 supplementation.

Fasting Plasma Pyridoxal Phosphate Concentration

Intervention	micromol/L (Mean)
	Baseline prior to vitamin supplementation	After 28-days of vitamin supplementation
Plasma Cystathionine Concentration	0.14	0.13

For all subjects, the concentration of plasma pyridoxal phosphate in fasting blood samples taken before and after the supplementation period will provide a direct measure of vitamin B6 nutritional status. (NCT01128244)
Timeframe: Fasting blood samples will be taken at baseline and after 28 days of vitamin B6 supplementation.

Flux of Homocysteine Remethylation From Serine-derived Carbon

Intervention	nmol/L (Mean)
	Baseline prior to vitamin supplementation	After 28-days of vitamin supplementation
Plasma Pyridoxal Phosphate Concentration	25.8	143

Data from analysis of serine, methionine and leucine in the timed blood samples of all subjects will provide a measurement of the metabolic rate of homocysteine remethylation from serine-derived carbon before and after vitamin B6 supplementation. These flux values may be slightly higher than flux of total homocysteine remethylation in Outcome Measure 1 because of the small contribution of methionine salvage to the flux measured in Outcome Measure 2. (NCT01128244)
Timeframe: Blood samples will be taken prior to infusion and at 0, 0.5, 1, 1.5, 2, 2.5, 3, 4, 5, 6, 7.5, and 9h. Infusions will be conducted at baseline and after 28 days

Plasma 3-hydroxykynurenine Concentration

Intervention	micromol/(kg x hr) (Mean)
	Baseline prior to vitamin supplementation	After 28-days of vitamin supplementation
Homocysteine Remethylation Flux From Serine	6.60	6.92

For all subjects, analysis of blood samples before and after vitamin B6 supplementation will allow evaluation of discriminating biomarkers using targeted metabolite profile analysis of one-carbon metabolism and tryptophan catabolism constituents. Also, we will conduct exploratory evaluation and potential identification of new biomarkers using metabolomics analysis on subjects before and after vitamin B6 supplementation. (NCT01128244)
Timeframe: April, 2010 - June, 2014

Total Remethylation of Homocysteine

Intervention	microl/L (Mean)
	Baseline prior to vitamin supplementation	After 28-days of vitamin supplementation
Secondary Analysis: Plasma 3-hydroxykynurenine Concentration	25.9	27.3

Data from analysis of serine, methionine and leucine in the timed blood samples of all subjects will provide a measurement of the metabolic rate of total remethylation of homocysteine before and after vitamin B6 supplementation. (NCT01128244)
Timeframe: Blood samples will be taken prior to infusion and at 0, 0.5, 1, 1.5, 2, 2.5, 3, 4, 5, 6, 7.5, and 9h. Infusions will be conducted at baseline and after 28 days

Article	Year
PRIMARY HYPEROXALURIA. Medicine, 1964, Volume: 43 Topics: Adolescent; Ascorbic Acid; Biochemical Phenomena; Biochemistry; Child; Classification; Diet; Genetic	1964
Molecular aspects of idiopathic urolithiasis. Molecular aspects of medicine, 1984, Volume: 7, Issue:1-2 Topics: Adult; Alcoholism; Animals; Calcium; Child; Child, Preschool; Dietary Carbohydrates; Dietary Fats; D	1984
Neurologic manifestations of acute porphyria. Seminars in liver disease, 1982, Volume: 2, Issue:2 Topics: Acute Disease; Aminolevulinic Acid; Animals; Central Nervous System; Depression; Electrophysiology;	1982
[Vitamin dependency]. Horumon to rinsho. Clinical endocrinology, 1975, Volume: 23, Issue:9 Topics: Anemia, Sideroblastic; Animals; Biotin; Crotonates; Cystathionine; gamma-Aminobutyric Acid; Glutamat	1975

Article	Year
Vitamin B6 is essential for serine de novo biosynthesis. Journal of inherited metabolic disease, 2017, Volume: 40, Issue:6 Topics: Brain; Cells, Cultured; Glycine; Humans; Pyridoxal Phosphate; Pyridoxine; Serine; Vitamin B 6; Vitam	2017
Pyridoxine supplementation does not alter in vivo kinetics of one-carbon metabolism but modifies patterns of one-carbon and tryptophan metabolites in vitamin B-6-insufficient oral contraceptive users. The American journal of clinical nutrition, 2015, Volume: 102, Issue:3 Topics: 3-Hydroxyanthranilic Acid; Adult; Biomarkers; Carbon; Contraceptives, Oral; Cystathionine; Dietary S	2015
Moderate dietary vitamin B-6 restriction raises plasma glycine and cystathionine concentrations while minimally affecting the rates of glycine turnover and glycine cleavage in healthy men and women. The Journal of nutrition, 2009, Volume: 139, Issue:3 Topics: Adult; Cystathionine; Diet; Female; Glycine; Humans; Male; Serine; Tetrahydrofolates; Vitamin B 6; V	2009
A mathematical model gives insights into the effects of vitamin B-6 deficiency on 1-carbon and glutathione metabolism. The Journal of nutrition, 2009, Volume: 139, Issue:4 Topics: Biomarkers; Carbon; Glutathione; Glycine; Glycine Hydroxymethyltransferase; Models, Biological; Oxid	2009
[Effect of vitamin B6 deficiency on metabolism of L-glutamic and L-aspartic acids, glycine, and ammonium acetate in the organism in rat]. Doklady Akademii nauk SSSR, 1953, Jun-21, Volume: 90, Issue:6 Topics: Acetates; Ammonium Compounds; Animals; Aspartic Acid; Glutamates; Glycine; Quaternary Ammonium Compo	1953
[Influence of vitamin B6 deficiency on conjugated glycine and taurine content of the bile in rats]. Biochimica et biophysica acta, 1956, Volume: 22, Issue:2 Topics: Animals; Bile; Bile Acids and Salts; Glycine; Rats; Salts; Taurine; Vitamin B 6 Deficiency	1956
[Influence of vitamin B6 deficiency on conjugated glycine and taurine content of the bile in rats]. Biochimica et biophysica acta, 1956, Volume: 22, Issue:2 Topics: Animals; Bile; Bile Acids and Salts; Glycine; Rats; Salts; Taurine; Vitamin B 6 Deficiency	1956
[Influence of vitamin B6 deficiency on conjugated glycine and taurine content of the bile in rats]. Biochimica et biophysica acta, 1956, Volume: 22, Issue:2 Topics: Animals; Bile; Bile Acids and Salts; Glycine; Rats; Salts; Taurine; Vitamin B 6 Deficiency	1956
[Influence of vitamin B6 deficiency on conjugated glycine and taurine content of the bile in rats]. Biochimica et biophysica acta, 1956, Volume: 22, Issue:2 Topics: Animals; Bile; Bile Acids and Salts; Glycine; Rats; Salts; Taurine; Vitamin B 6 Deficiency	1956
Endogenous oxalate synthesis and glycine, serine, deoxypyridoxine interrelationships in vitamin B6-deficient rats. The Journal of biological chemistry, 1959, Volume: 234 Topics: Animals; Glycine; Oxalates; Rats; Serine; Vitamin B 6; Vitamin B 6 Deficiency	1959
VARIATION OF FREE AMINO ACIDS IN CORCYRA CEPHALONICA ST. (RICE MOTH LARVAE) DURING SOME B VITAMIN DEFICIENCIES. The Journal of experimental zoology, 1963, Volume: 153 Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Chromatography; Glutamates; Glycine; Insecta; Larva; L	1963
FREE AMINO ACIDS IN PLASMA AND TISSUES OF RATS FED A VITAMIN B6-DEFICIENT DIET. The Journal of nutrition, 1964, Volume: 82 Topics: Alanine; Amino Acids; Aspartic Acid; Blood; Diet; Glycine; Liver; Muscles; Proteins; Rats; Research;	1964
THE METABOLIC DEFECT OF PRIMARY HYPEROXALURIA. Transactions of the Association of American Physicians, 1964, Volume: 77 Topics: Amino Acid Metabolism, Inborn Errors; Calcinosis; Glycine; Glycolates; Humans; Hyperoxaluria, Primar	1964
THE EFFECT OF VITAMIN B6 DEFICIENCY IN RATS ON THE METABOLISM OF OXALIC ACID PRECURSORS. The Journal of biological chemistry, 1965, Volume: 240 Topics: Acetates; Amino Alcohols; Carbon Dioxide; Glucose; Glycine; Glycolates; Glycols; Hippurates; Kidney;	1965
Incorporation of C14 of glycine into protein and lipide fractions of homogenates. Archives of biochemistry, 1949, Volume: 21, Issue:1 Topics: Glycine; Humans; Lipids; Proteins; Pyridoxine; Vitamin B 6 Deficiency	1949
The effect of a nutritional pyridoxine deficiency on free amino acids and related substances in mouse brain. Journal of neurochemistry, 1967, Volume: 14, Issue:1 Topics: Alanine; Amino Acids; Aminobutyrates; Animals; Brain Chemistry; Chromatography, Ion Exchange; Diet;	1967
Studies on primary hyperoxaluria. 3. Transamination reactions of glyoxylate in human tissue preparations. The Journal of laboratory and clinical medicine, 1967, Volume: 70, Issue:3 Topics: Adolescent; Adult; Alanine; Child; Child, Preschool; Female; Glomerulonephritis; Glutamates; Glycine	1967
Serine utilization in the chick as influenced by dietary pyridoxine. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1980, Volume: 163, Issue:4 Topics: Animals; Aspartate Aminotransferases; Chickens; Glycine; Growth; In Vitro Techniques; Pyridoxine; Se	1980
Effects of hydroxyproline and vitamin B-6 on oxalate synthesis in rats. The Journal of nutrition, 1981, Volume: 111, Issue:7 Topics: Animals; Body Weight; Carbon Dioxide; Diet; Glycine; Glycolates; Glyoxylates; Hydroxyproline; Male;	1981
Stimulation of cholesterol metabolism in pyridoxine-deficient rats. Journal of nutritional science and vitaminology, 1982, Volume: 28, Issue:2 Topics: Animals; Bile; Bile Acids and Salts; Cholesterol; Feces; Glycine; Male; Rats; Rats, Inbred Strains;	1982
Factors affecting endogenous oxalate synthesis and its excretion in feces and urine in rats. The Journal of nutrition, 1982, Volume: 112, Issue:11 Topics: Animals; Calcium, Dietary; Feces; Glycine; Hydroxyproline; Intestinal Mucosa; Kidney; Liver; Male; O	1982
Transient nonketotic hyperglycinemia in an asphyxiated patient with pyridoxine-dependent seizures. Pediatric neurology, 2000, Volume: 22, Issue:3 Topics: Asphyxia Neonatorum; Brain; Electroencephalography; Glycine; Humans; Hyperglycinemia, Nonketotic; In	2000
Interrelationships in rats among dietary vitamin B6, glycine and hydroxyproline. Effects of oxalate, glyoxylate, glycolate, and glycine on liver enzymes. The Journal of nutrition, 1979, Volume: 109, Issue:1 Topics: Animals; ATP Citrate (pro-S)-Lyase; Glucosephosphate Dehydrogenase; Glycine; Glycolates; Glyoxylates	1979
Oxalate excretion during carbohydrate infusions. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Beiheft, 1976, Volume: 15 Topics: Animals; Creatinine; Fructose; Glucose; Glycine; Glyoxylates; Hexoses; Humans; Infusions, Parenteral	1976
Abnormal endogenous amino acid release in brain slices from vitamin B-6 restricted neonatal rats. Neuroscience letters, 1991, Jan-02, Volume: 121, Issue:1-2 Topics: Amino Acids; Animals; Animals, Newborn; Brain Chemistry; Chromatography, High Pressure Liquid; Elect	1991
Regional changes in the concentrations of glutamate, glycine, taurine, and GABA in the vitamin B-6 deficient developing rat brain: association with neonatal seizures. Neurochemical research, 1989, Volume: 14, Issue:9 Topics: Amino Acids; Animals; Animals, Newborn; Brain; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic	1989
The effects of vitamin B-6 deficiency in chronically azotemic and sham-operated rats. Kidney international. Supplement, 1987, Volume: 22 Topics: Alanine; Animals; Asparagine; Aspartate Aminotransferases; Chronic Disease; Creatinine; Erythrocytes	1987
[Report on a vitamin B 6 deficiency anemia]. Folia haematologica (Leipzig, Germany : 1928), 1966, Volume: 86, Issue:4 Topics: Adult; Anemia, Sideroblastic; Folic Acid; Glycine; Humans; Male; Pyridoxine; Serine; Vitamin B 6 Def	1966
The metabolism of oxalate precursors in isolated perfused rat livers. Archives of biochemistry and biophysics, 1972, Volume: 153, Issue:2 Topics: Alanine; Animals; Carbon Isotopes; Ethanolamines; Female; Glycine; Glycolates; Glycols; Glyoxylates;	1972
The effect of partial hepatectomy on the toxicity of ethylene glycol, glycolic acid, glyoxylic acid and glycine. Toxicology and applied pharmacology, 1973, Volume: 24, Issue:4 Topics: Animals; Carbon Isotopes; Glycine; Glycolates; Glycols; Glyoxylates; Hepatectomy; In Vitro Technique	1973
A study of plasma free amino acid levels. VI. High plasma glycine levels of some women. Metabolism: clinical and experimental, 1973, Volume: 22, Issue:6 Topics: Adolescent; Adult; Age Factors; Aged; Amino Acids; Animals; Child; Child, Preschool; Female; Folic A	1973
Amino acid metabolism in rats fed a high protein diet without pyridoxine. The Journal of nutrition, 1974, Volume: 104, Issue:3 Topics: Alanine; Amino Acids; Animals; Autoanalysis; Caseins; Centrifugation; Chromatography, Paper; Creatin	1974
Serum aminotransferase activities and plasma free amino acid concentration as criteria for pyridoxine nutritional status of chicks. The British journal of nutrition, 1972, Volume: 28, Issue:2 Topics: Alanine Transaminase; Amino Acids; Aminobutyrates; Ammonia; Animal Nutritional Physiological Phenome	1972
The effect of pyridoxine deficiency on intestinal absorption of amino acids and peptides in the rat. The British journal of nutrition, 1972, Volume: 28, Issue:3 Topics: Alanine; Amino Acids; Animals; Dipeptides; Glycine; Intestinal Absorption; Jejunum; Leucine; Male; M	1972
[Oxalate metabolism and thiamine-pyridoxine intake of the rat]. International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition, 1972, Volume: 42, Issue:3 Topics: Animal Nutritional Physiological Phenomena; Animals; Calcium; Crystallization; Food Deprivation; Gly	1972
Cholesterol metabolism and vitamin B 6 . IV. Synthesis of cholic acid conjugates in vitamin B 6 -deficient rats. Canadian journal of biochemistry, 1971, Volume: 49, Issue:9 Topics: Animals; Bile Acids and Salts; Carbon Isotopes; Cholesterol; Chromatography, Thin Layer; Diet; Glyci	1971
Pyridoxine deficiency and brain amino acids. Annals of the New York Academy of Sciences, 1969, Sep-30, Volume: 166, Issue:1 Topics: Acetates; Alanine; Amino Acids; Aminobutyrates; Animals; Brain; Brain Chemistry; Diet; Glutamates; G	1969
Effect of vitamin B6 depletion in adult man on the plasma concentration and the urinary excretion of free amino acids. The Journal of nutrition, 1971, Volume: 101, Issue:2 Topics: Adult; Alanine; Amino Acids; Fasting; Glycine; Humans; Isoleucine; Leucine; Male; Pyridoxine; Serine	1971
Some effects of amino acid deficiencies on antibody formation in the rat. The Journal of nutrition, 1968, Volume: 95, Issue:2 Topics: Amino Acids; Animals; Antibody Formation; Antigens; Antimetabolites; Body Weight; Deficiency Disease	1968
Glycine metabolism in vitamin B6-deficient and deoxypyridoxine-treated rats. The Journal of nutrition, 1969, Volume: 98, Issue:1 Topics: Animals; Carbon Dioxide; Carbon Isotopes; Glycine; Glycolates; Glyoxylates; In Vitro Techniques; Kid	1969
Role of pyridoxine in glutathione metabolism. The Biochemical journal, 1964, Volume: 90, Issue:1 Topics: Animals; Erythrocytes; Glutamates; Glutathione; Glycine; In Vitro Techniques; Liver; Pyridoxine; Rat	1964
Endogenous oxalate synthesis in male and female rats. Toxicology and applied pharmacology, 1965, Volume: 7, Issue:4 Topics: Alcohol Oxidoreductases; Amino Alcohols; Animals; Autoradiography; Carboxy-Lyases; Chromatography; F	1965

glycine and Deficiency, Pyridoxine