Page last updated: 2024-10-18

glycine and Colorectal Neoplasms

glycine has been researched along with Colorectal Neoplasms in 35 studies

Colorectal Neoplasms: Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.

Research Excerpts

ExcerptRelevanceReference
"We tested these hypotheses among participants in the Aspirin/Folate Polyp Prevention Study who were randomly assigned to placebo or to aspirin treatment (81 or 325 mg daily) and followed for 3 years for the occurrence of new adenomas."7.73Ornithine decarboxylase polymorphism modification of response to aspirin treatment for colorectal adenoma prevention. ( Ahnen, DJ; Baron, JA; Barry, EL; Bhat, S; Burke, CA; Grau, MV; Haile, RW; O'Brien, TG; Sandler, RS, 2006)
"Glycine has been shown to protect livers from CTx-induced injury and oxidative stress, and it reduces platelet aggregation and improves microperfusion."5.56Dietary Glycine Prevents FOLFOX Chemotherapy-Induced Heart Injury: A Colorectal Cancer Liver Metastasis Treatment Model in Rats. ( Bausys, A; Feldbacher, N; Hoefler, G; Kolb-Lenz, D; Leber, B; Maneikyte, J; Schemmer, P; Stiegler, P; Strupas, K, 2020)
"Fucoxanthinol (FxOH) is a strong anticancer metabolite of fucoxanthin that accumulates in abundance in edible brown algae and promises human health benefits."5.48Glycine and succinic acid are effective indicators of the suppression of epithelial-mesenchymal transition by fucoxanthinol in colorectal cancer stem-like cells. ( Endo, T; Hamada, J; Kudoh, S; Maeda, H; Mima, M; Miyashita, K; Mutoh, M; Osada, K; Terasaki, M, 2018)
"Glycine is a non-toxic amino acid with suspected anti-angiogenic effects."5.43Glycine inhibits angiogenesis in colorectal cancer: role of endothelial cells. ( Bruns, H; Kazanavicius, D; Saeedi, MA; Schemmer, P; Schultze, D; Strupas, K; Yamanaka, K, 2016)
"We tested these hypotheses among participants in the Aspirin/Folate Polyp Prevention Study who were randomly assigned to placebo or to aspirin treatment (81 or 325 mg daily) and followed for 3 years for the occurrence of new adenomas."3.73Ornithine decarboxylase polymorphism modification of response to aspirin treatment for colorectal adenoma prevention. ( Ahnen, DJ; Baron, JA; Barry, EL; Bhat, S; Burke, CA; Grau, MV; Haile, RW; O'Brien, TG; Sandler, RS, 2006)
"Glycine has been shown to protect livers from CTx-induced injury and oxidative stress, and it reduces platelet aggregation and improves microperfusion."1.56Dietary Glycine Prevents FOLFOX Chemotherapy-Induced Heart Injury: A Colorectal Cancer Liver Metastasis Treatment Model in Rats. ( Bausys, A; Feldbacher, N; Hoefler, G; Kolb-Lenz, D; Leber, B; Maneikyte, J; Schemmer, P; Stiegler, P; Strupas, K, 2020)
"Fucoxanthinol (FxOH) is a strong anticancer metabolite of fucoxanthin that accumulates in abundance in edible brown algae and promises human health benefits."1.48Glycine and succinic acid are effective indicators of the suppression of epithelial-mesenchymal transition by fucoxanthinol in colorectal cancer stem-like cells. ( Endo, T; Hamada, J; Kudoh, S; Maeda, H; Mima, M; Miyashita, K; Mutoh, M; Osada, K; Terasaki, M, 2018)
" The sensitivity of human colorectal carcinoma cells to the PI Ixazomib was assessed via in vitro and in vivo dose-response experiments."1.48Non-invasive imaging of disrupted protein homeostasis induced by proteasome inhibitor treatment using chemical exchange saturation transfer MRI. ( Bradley, D; Chattopadhyay, N; Gibb, A; Golay, X; Johnson, SP; Lythgoe, MF; Pedley, RB; Ramasawmy, R; Taylor, V; Walker-Samuel, S; Zhu, Y, 2018)
"Glycine is a non-toxic amino acid with suspected anti-angiogenic effects."1.43Glycine inhibits angiogenesis in colorectal cancer: role of endothelial cells. ( Bruns, H; Kazanavicius, D; Saeedi, MA; Schemmer, P; Schultze, D; Strupas, K; Yamanaka, K, 2016)
"The increased risk of colorectal cancer in biallelic and monoallelic MYH gene mutation carriers was not consistently associated with the development of multiple adenomatous polyps."1.32Association between biallelic and monoallelic germline MYH gene mutations and colorectal cancer risk. ( Aronson, M; Cleary, SP; Cotterchio, M; Croitoru, ME; Di Nicola, N; Gallinger, S; Gryfe, R; Knight, J; Manno, M; Redston, M; Selander, T, 2004)
"Once positive the circulating tumor cells persisted in subsequent multiple blood samples."1.31K-ras mutational analysis of polyclonal colorectal cancers identifies uniclonal circulating tumor cells. ( Krygier, S; Luchtefeld, MA; Senagore, AJ; Thebo, JS, 2001)

Research

Studies (35)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (11.43)18.2507
2000's10 (28.57)29.6817
2010's16 (45.71)24.3611
2020's5 (14.29)2.80

Authors

AuthorsStudies
Zhu, C2
Huang, F1
Li, Y1
Zhou, K1
Xie, H1
Xia, L1
Xie, G1
Li, K1
Wu, JL1
Qin, B1
Fan, Z1
Tang, Q1
Lu, W1
Zhang, H2
Xing, F1
Meng, M1
Zou, S1
Wei, W1
Chen, H1
Cai, J2
Wang, H1
Fang, L2
Bian, X1
Chen, C1
Lan, P1
Ghesquière, B1
Lee, MH1
Maneikyte, J1
Bausys, A1
Leber, B2
Feldbacher, N1
Hoefler, G1
Kolb-Lenz, D1
Strupas, K4
Stiegler, P2
Schemmer, P4
Kvietkauskas, M1
Zitkute, V1
Rahmani, F1
Hashemzehi, M1
Avan, A1
Barneh, F1
Asgharzadeh, F1
Moradi Marjaneh, R1
Soleimani, A1
Parizadeh, M1
Ferns, GA1
Ghayour Mobarhan, M1
Ryzhikov, M1
Afshari, AR1
Ahmadian, MR1
Giovannetti, E1
Jafari, M1
Khazaei, M1
Hassanian, SM1
Chapelle, T1
Op de Beeck, B1
Driessen, A1
Roeyen, G1
Bracke, B1
Hartman, V1
Huyghe, I1
Morrison, S1
Ysebaert, D1
Francque, S1
Terasaki, M1
Mima, M1
Kudoh, S1
Endo, T1
Maeda, H1
Hamada, J1
Osada, K1
Miyashita, K1
Mutoh, M1
Zhu, Y1
Ramasawmy, R1
Johnson, SP1
Taylor, V1
Gibb, A1
Pedley, RB2
Chattopadhyay, N1
Lythgoe, MF1
Golay, X1
Bradley, D1
Walker-Samuel, S1
Yue, D1
Sun, X1
Smith, CG1
West, H1
Harris, R1
Idziaszczyk, S1
Maughan, TS1
Kaplan, R1
Richman, S1
Quirke, P1
Seymour, M1
Moskvina, V1
Steinke, V1
Propping, P1
Hes, FJ1
Wijnen, J1
Cheadle, JP1
Ho, AS1
Chen, CH1
Cheng, CC1
Wang, CC1
Lin, HC1
Luo, TY1
Lien, GS1
Chang, J1
Mazurenko, NN1
Gagarin, IM1
Tsyganova, IV1
Mochal'nikova, VV1
Breder, VV1
Geisel, D1
Lüdemann, L1
Gebauer, B1
Fröling, V1
Prasad, V1
Heimann, U1
Stockmann, M1
Malinowski, M1
Hamm, B1
Brenner, W1
Denecke, T1
Rocha, C1
Papon, L1
Cacheux, W1
Marques Sousa, P1
Lascano, V1
Tort, O1
Giordano, T1
Vacher, S1
Lemmers, B1
Mariani, P1
Meseure, D1
Medema, JP1
Bièche, I1
Hahne, M1
Janke, C1
Truant, S1
Baillet, C1
Deshorgue, AC1
Leteurtre, E1
Hebbar, M1
Ernst, O1
Huglo, D1
Pruvot, FR1
Bruns, H2
Kazanavicius, D1
Schultze, D1
Saeedi, MA1
Yamanaka, K1
Banerjee, K1
Das, S1
Majumder, S1
Majumdar, S1
Biswas, J1
Choudhuri, SK1
Berndt, SI1
Huang, WY1
Yeager, M1
Weissfeld, JL1
Chanock, SJ1
Hayes, RB1
Holdhoff, M1
Schmidt, K1
Donehower, R1
Diaz, LA1
Mikalauskas, S1
Mikalauskiene, L1
Nickkholgh, A1
Hoffmann, K1
Longerich, T1
Büchler, MW1
Zulhabri, O1
Rahman, J1
Ismail, S1
Isa, MR1
Wan Zurinah, WN1
Ferrari, P1
Nicolini, A1
Manca, ML1
Rossi, G1
Anselmi, L2
Conte, M1
Carpi, A1
Bonino, F1
Mao, C1
Huang, YF1
Yang, ZY1
Zheng, DY1
Chen, JZ1
Tang, JL1
Gismondi, V1
Meta, M1
Bonelli, L1
Radice, P1
Sala, P1
Bertario, L1
Viel, A1
Fornasarig, M1
Arrigoni, A1
Gentile, M1
Ponz de Leon, M1
Mareni, C1
Bruzzi, P1
Varesco, L1
Patel, O1
Dumesny, C1
Giraud, AS1
Baldwin, GS1
Shulkes, A1
Croitoru, ME1
Cleary, SP1
Di Nicola, N1
Manno, M1
Selander, T1
Aronson, M1
Redston, M1
Cotterchio, M1
Knight, J1
Gryfe, R1
Gallinger, S1
Menin, C1
Scaini, MC1
De Salvo, GL1
Biscuola, M1
Quaggio, M1
Esposito, G1
Belluco, C1
Montagna, M1
Agata, S1
D'Andrea, E1
Nitti, D1
Amadori, A1
Bertorelle, R1
Barry, EL1
Baron, JA1
Bhat, S1
Grau, MV1
Burke, CA1
Sandler, RS1
Ahnen, DJ1
Haile, RW1
O'Brien, TG1
Tuupanen, S1
Alhopuro, P1
Mecklin, JP1
Järvinen, H1
Aaltonen, LA1
Shanmugam, KS1
Brenner, H1
Hoffmeister, M1
Chang-Claude, J1
Burwinkel, B1
Fossum, B1
Gedde-Dahl, T1
Breivik, J1
Eriksen, JA1
Spurkland, A1
Thorsby, E1
Gaudernack, G1
Michael, NP1
Chester, KA1
Melton, RG1
Robson, L1
Nicholas, W1
Boden, JA1
Begent, RH1
Sherwood, RF1
Minton, NP1
Al-Mulla, F1
Going, JJ1
Sowden, ET1
Winter, A1
Pickford, IR1
Birnie, GD1
Conover, CD1
Greenwald, RB1
Pendri, A1
Gilbert, CW1
Shum, KL1
Thebo, JS1
Senagore, AJ1
Krygier, S1
Luchtefeld, MA1

Reviews

1 review available for glycine and Colorectal Neoplasms

ArticleYear
KRAS p.G13D mutation and codon 12 mutations are not created equal in predicting clinical outcomes of cetuximab in metastatic colorectal cancer: a systematic review and meta-analysis.
    Cancer, 2013, Feb-15, Volume: 119, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Amino Acid Substitution; Antibodies, Monoclonal; Antibodies, Monoclo

2013

Trials

1 trial available for glycine and Colorectal Neoplasms

ArticleYear
Treatment of mild non-chemotherapy-induced iron deficiency anemia in cancer patients: comparison between oral ferrous bisglycinate chelate and ferrous sulfate.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2012, Volume: 66, Issue:6

    Topics: Aged; Anemia, Iron-Deficiency; Breast Neoplasms; Colorectal Neoplasms; Dietary Supplements; Female;

2012

Other Studies

33 other studies available for glycine and Colorectal Neoplasms

ArticleYear
Distinct Urinary Metabolic Biomarkers of Human Colorectal Cancer.
    Disease markers, 2022, Volume: 2022

    Topics: Biomarkers; Biomarkers, Tumor; Colorectal Neoplasms; Glycine; Humans; Mass Spectrometry; Metabolomic

2022
ILF3 is a substrate of SPOP for regulating serine biosynthesis in colorectal cancer.
    Cell research, 2020, Volume: 30, Issue:2

    Topics: Animals; Biomarkers, Tumor; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Epidermal Gr

2020
Dietary Glycine Prevents FOLFOX Chemotherapy-Induced Heart Injury: A Colorectal Cancer Liver Metastasis Treatment Model in Rats.
    Nutrients, 2020, Aug-28, Volume: 12, Issue:9

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms

2020
Dietary Melatonin and Glycine Decrease Tumor Growth through Antiangiogenic Activity in Experimental Colorectal Liver Metastasis.
    Nutrients, 2021, Jun-13, Volume: 13, Issue:6

    Topics: Angiogenesis Inhibitors; Animals; Cell Line, Tumor; Colorectal Neoplasms; Diet; Glycine; Leukocyte C

2021
Rigosertib elicits potent anti-tumor responses in colorectal cancer by inhibiting Ras signaling pathway.
    Cellular signalling, 2021, Volume: 85

    Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Glycine; Humans; Sig

2021
Estimation of the future remnant liver function is a better tool to predict post-hepatectomy liver failure than platelet-based liver scores.
    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 2017, Volume: 43, Issue:12

    Topics: Aniline Compounds; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasm

2017
Glycine and succinic acid are effective indicators of the suppression of epithelial-mesenchymal transition by fucoxanthinol in colorectal cancer stem-like cells.
    Oncology reports, 2018, Volume: 40, Issue:1

    Topics: Apoptosis; beta Carotene; Cell Movement; Cell Proliferation; Colorectal Neoplasms; Epithelial-Mesenc

2018
Non-invasive imaging of disrupted protein homeostasis induced by proteasome inhibitor treatment using chemical exchange saturation transfer MRI.
    Scientific reports, 2018, 10-10, Volume: 8, Issue:1

    Topics: Amides; Amines; Animals; Apoptosis; Boron Compounds; Cell Line, Tumor; Cell Survival; Colorectal Neo

2018
Ixazomib promotes CHOP-dependent DR5 induction and apoptosis in colorectal cancer cells.
    Cancer biology & therapy, 2019, Volume: 20, Issue:3

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Boron Compounds; C

2019
Role of the oxidative DNA damage repair gene OGG1 in colorectal tumorigenesis.
    Journal of the National Cancer Institute, 2013, Aug-21, Volume: 105, Issue:16

    Topics: Adenoma; Adult; Aged; Aged, 80 and over; Alleles; Carcinoma; Case-Control Studies; Colorectal Neopla

2013
Neutrophil elastase as a diagnostic marker and therapeutic target in colorectal cancers.
    Oncotarget, 2014, Jan-30, Volume: 5, Issue:2

    Topics: Amino Acid Sequence; Animals; Biomarkers, Tumor; Colorectal Neoplasms; Glycine; Humans; Leukocyte El

2014
[The frequency and spectrum of KRAS mutations in metastatic colorectal cancer].
    Voprosy onkologii, 2013, Volume: 59, Issue:6

    Topics: Adult; Aged; Amino Acid Substitution; Aspartic Acid; Colorectal Neoplasms; Female; Glycine; Humans;

2013
Optimized separation of left and right liver lobe in dynamic (99m)Tc-mebrofenin hepatobiliary scintigraphy using a hybrid SPECT-CT scanner.
    Annals of nuclear medicine, 2014, Volume: 28, Issue:9

    Topics: Aged; Aged, 80 and over; Aniline Compounds; Colorectal Neoplasms; Female; Glycine; Humans; Imino Aci

2014
Tubulin glycylases are required for primary cilia, control of cell proliferation and tumor development in colon.
    The EMBO journal, 2014, Oct-01, Volume: 33, Issue:19

    Topics: Animals; Blotting, Western; Carcinogens; Cell Proliferation; Cells, Cultured; Cilia; Colon; Colonic

2014
Drop of Total Liver Function in the Interstages of the New Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy Technique: Analysis of the "Auxiliary Liver" by HIDA Scintigraphy.
    Annals of surgery, 2016, Volume: 263, Issue:3

    Topics: Aged; Aged, 80 and over; Aniline Compounds; Colorectal Neoplasms; Combined Modality Therapy; Emboliz

2016
Glycine inhibits angiogenesis in colorectal cancer: role of endothelial cells.
    Amino acids, 2016, Volume: 48, Issue:11

    Topics: Animals; Colorectal Neoplasms; Glycine; Human Umbilical Vein Endothelial Cells; Humans; Neovasculari

2016
Modulation of cell death in human colorectal and breast cancer cells through a manganese chelate by involving GSH with intracellular p53 status.
    Molecular and cellular biochemistry, 2017, Volume: 427, Issue:1-2

    Topics: Apoptosis; Breast Neoplasms; Chelating Agents; Colorectal Neoplasms; Female; Gene Expression Regulat

2017
Genetic variants in frizzled-related protein (FRZB) and the risk of colorectal neoplasia.
    Cancer causes & control : CCC, 2009, Volume: 20, Issue:4

    Topics: Adenoma; Algorithms; Alleles; Amino Acid Substitution; Black or African American; Case-Control Studi

2009
Analysis of circulating tumor DNA to confirm somatic KRAS mutations.
    Journal of the National Cancer Institute, 2009, Sep-16, Volume: 101, Issue:18

    Topics: Amino Acid Substitution; Colorectal Neoplasms; DNA, Neoplasm; Flow Cytometry; Glycine; Humans; Male;

2009
Dietary glycine protects from chemotherapy-induced hepatotoxicity.
    Amino acids, 2011, Volume: 40, Issue:4

    Topics: Animals; Antineoplastic Agents; Camptothecin; Chemical and Drug Induced Liver Injury; Colorectal Neo

2011
Predominance of G to A codon 12 mutation K-ras gene in Dukes' B colorectal cancer.
    Singapore medical journal, 2012, Volume: 53, Issue:1

    Topics: Adenine; Adenoma; Adult; Aged; Aged, 80 and over; Aspartic Acid; Carcinoma; Codon; Colorectal Neopla

2012
Prevalence of the Y165C, G382D and 1395delGGA germline mutations of the MYH gene in Italian patients with adenomatous polyposis coli and colorectal adenomas.
    International journal of cancer, 2004, May-01, Volume: 109, Issue:5

    Topics: Adenine; Adenoma; Adenomatous Polyposis Coli; Adult; Aged; Aspartic Acid; Case-Control Studies; Colo

2004
Stimulation of proliferation and migration of a colorectal cancer cell line by amidated and glycine-extended gastrin-releasing peptide via the same receptor.
    Biochemical pharmacology, 2004, Dec-01, Volume: 68, Issue:11

    Topics: Bombesin; Cell Movement; Cell Proliferation; Colorectal Neoplasms; Enzyme Activation; Focal Adhesion

2004
Association between biallelic and monoallelic germline MYH gene mutations and colorectal cancer risk.
    Journal of the National Cancer Institute, 2004, Nov-03, Volume: 96, Issue:21

    Topics: Adenomatous Polyposis Coli; Aspartic Acid; Base Pair Mismatch; Biomarkers, Tumor; Case-Control Studi

2004
Association between MDM2-SNP309 and age at colorectal cancer diagnosis according to p53 mutation status.
    Journal of the National Cancer Institute, 2006, Feb-15, Volume: 98, Issue:4

    Topics: Adult; Age Factors; Aged; Aged, 80 and over; Colorectal Neoplasms; Female; Genes, p53; Genotype; Gly

2006
Ornithine decarboxylase polymorphism modification of response to aspirin treatment for colorectal adenoma prevention.
    Journal of the National Cancer Institute, 2006, Oct-18, Volume: 98, Issue:20

    Topics: Adenoma; Adenomatous Polyposis Coli; Aged; Alanine; Anticarcinogenic Agents; Aspirin; Colorectal Neo

2006
No evidence for association of NOD2 R702W and G908R with colorectal cancer.
    International journal of cancer, 2007, Jul-01, Volume: 121, Issue:1

    Topics: Arginine; Colorectal Neoplasms; Female; Finland; Glycine; Humans; Male; Middle Aged; Mutation, Misse

2007
The functional genetic variant Arg324Gly of frizzled-related protein is associated with colorectal cancer risk.
    Carcinogenesis, 2007, Volume: 28, Issue:9

    Topics: Amino Acid Substitution; Arginine; Case-Control Studies; Colorectal Neoplasms; Genetic Linkage; Gene

2007
p21-ras-peptide-specific T-cell responses in a patient with colorectal cancer. CD4+ and CD8+ T cells recognize a peptide corresponding to a common mutation (13Gly-->Asp).
    International journal of cancer, 1994, Jan-02, Volume: 56, Issue:1

    Topics: Adenocarcinoma; Amino Acid Sequence; Aspartic Acid; CD4-Positive T-Lymphocytes; CD8 Antigens; Cells,

1994
In vitro and in vivo characterisation of a recombinant carboxypeptidase G2::anti-CEA scFv fusion protein.
    Immunotechnology : an international journal of immunological engineering, 1996, Volume: 2, Issue:1

    Topics: Animals; Artificial Gene Fusion; Blotting, Western; Carcinoembryonic Antigen; Chromatography, Affini

1996
Heterogeneity of mutant versus wild-type Ki-ras in primary and metastatic colorectal carcinomas, and association of codon-12 valine with early mortality.
    The Journal of pathology, 1998, Volume: 185, Issue:2

    Topics: Adenocarcinoma; Adenoma; Adult; Aged; Aged, 80 and over; Colorectal Neoplasms; Genes, ras; Genetic H

1998
Camptothecin delivery systems: enhanced efficacy and tumor accumulation of camptothecin following its conjugation to polyethylene glycol via a glycine linker.
    Cancer chemotherapy and pharmacology, 1998, Volume: 42, Issue:5

    Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Colorectal Neoplasms; Drug Carriers; Glyci

1998
K-ras mutational analysis of polyclonal colorectal cancers identifies uniclonal circulating tumor cells.
    The American surgeon, 2001, Volume: 67, Issue:8

    Topics: Aspartic Acid; Colorectal Neoplasms; Disease Progression; DNA Mutational Analysis; Genes, ras; Glyci

2001