Page last updated: 2024-10-18

glycine and Cholestasis

glycine has been researched along with Cholestasis in 23 studies

Cholestasis: Impairment of bile flow due to obstruction in small bile ducts (INTRAHEPATIC CHOLESTASIS) or obstruction in large bile ducts (EXTRAHEPATIC CHOLESTASIS).

Research Excerpts

ExcerptRelevanceReference
"Ursodeoxycholic acid (UDCA) exerts anticholestatic, antifibrotic and antiproliferative effects in primary biliary cirrhosis (PBC) via mechanisms not yet fully understood."9.16Effect of ursodeoxycholic acid on bile acid profiles and intestinal detoxification machinery in primary biliary cirrhosis and health. ( Bastiaansen, BA; Beuers, U; Dilger, K; Hohenester, S; Rust, C; Schaap, FG; Winkler-Budenhofer, U, 2012)
"Ursodeoxycholic acid (UDCA) exerts anticholestatic, antifibrotic and antiproliferative effects in primary biliary cirrhosis (PBC) via mechanisms not yet fully understood."5.16Effect of ursodeoxycholic acid on bile acid profiles and intestinal detoxification machinery in primary biliary cirrhosis and health. ( Bastiaansen, BA; Beuers, U; Dilger, K; Hohenester, S; Rust, C; Schaap, FG; Winkler-Budenhofer, U, 2012)
"Cholestasis is the stoppage of bile flow which could lead to serious clinical complications if not managed."1.48Mitochondria protection as a mechanism underlying the hepatoprotective effects of glycine in cholestatic mice. ( Abdoli, N; Aghaei, F; Ahmadi, A; Azarpira, N; Esfandiari, A; Ghanbarinejad, V; Heidari, R; Mohammadi, H; Niknahad, H; Ommati, MM, 2018)
" A pharmacokinetic model was developed based on blood, urine and bile concentration-time profiles obtained in healthy humans, and the effect of changes in hepatic uptake and/or excretion associated with disease states (hyperbilirubinemia and cholestasis) on MEB disposition was simulated."1.35Use of tc-99m mebrofenin as a clinical probe to assess altered hepatobiliary transport: integration of in vitro, pharmacokinetic modeling, and simulation studies. ( Brouwer, KL; Ghibellini, G; Leslie, EM; Pollack, GM, 2008)
"Subsequently, an obstructed choledochal cyst was diagnosed clinically, and a right hepatectomy followed by a Roux-en-Y loop implantation on the raw surface of the left lobe were performed."1.31Hepatobiliary scintigraphic findings in obstructed intrahepatic choledochal cyst before and after surgery. ( Agarwala, S; Choudhury, S; Dasan, B; Kumar, R; Malhotra, A, 2001)
"Glycine/taurine was greater in group II versus III and varied directly with serum bile acid concentration."1.28Altered glycine and taurine conjugation of bile acids following aluminum administration to rats. ( Heyman, MB; Klein, GL; Lee, TC; Rassin, DK, 1989)

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-199013 (56.52)18.7374
1990's4 (17.39)18.2507
2000's4 (17.39)29.6817
2010's2 (8.70)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Heidari, R1
Ghanbarinejad, V1
Mohammadi, H1
Ahmadi, A1
Ommati, MM1
Abdoli, N1
Aghaei, F1
Esfandiari, A1
Azarpira, N1
Niknahad, H1
Ghibellini, G1
Leslie, EM1
Pollack, GM1
Brouwer, KL1
Froh, M1
Zhong, Z1
Walbrun, P1
Lehnert, M1
Netter, S1
Wiest, R1
Conzelmann, L1
Gabele, E1
Hellerbrand, C1
Scholmerich, J1
Thurman, RG1
Dilger, K1
Hohenester, S1
Winkler-Budenhofer, U1
Bastiaansen, BA1
Schaap, FG1
Rust, C1
Beuers, U1
Linnet, K1
Andersen, JR1
Hoshita, T1
Yamanaka, M1
Sano, N1
Itokazu, K1
Yokote, M1
Levy, M1
Finestone, H1
Fechner, C1
Miyazaki, S1
Tanaka, H1
Horikawa, R1
Tsuchiya, H1
Imai, K1
Donovan, JM1
Yousef, IM1
Carey, MC1
Bossard, R1
Stieger, B1
O'Neill, B1
Fricker, G1
Meier, PJ1
Balich, S1
Jarboe, GL1
Stevens, JS1
Khanduri, A1
Agarwal, DK1
Mittal, BR1
Choudhuri, G1
Rolo, AP1
Oliveira, PJ1
Moreno, AJ1
Palmeira, CM1
Kumar, R1
Choudhury, S1
Dasan, B1
Agarwala, S1
Malhotra, A1
Danielsson, H1
Sjövall, J1
Mirkovitch, V1
Sepúlveda, FV1
Menge, H1
Robinson, JW1
Klein, GL1
Lee, TC1
Heyman, MB1
Rassin, DK1
Stremmel, W1
Murphy, GM1
Ross, A1
Billing, BH1
Drozdz, H1
Neale, G1
Lewis, B1
Weaver, V1
Panveliwalla, D1
Brunner, G1
Sommer, J1
Kattermann, R1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
[NCT00529009]Phase 10 participants Interventional2007-05-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for glycine and Cholestasis

ArticleYear
[Conjugation and deconjugation of bile acids].
    Nihon rinsho. Japanese journal of clinical medicine, 1984, Volume: 42, Issue:7

    Topics: Bile Acids and Salts; Cholestasis; Glucuronates; Glycine; Humans; Liver; Sulfuric Acids; Taurine

1984
[Abnormal bile acids in obstructive jaundice].
    Nihon rinsho. Japanese journal of clinical medicine, 1984, Volume: 42, Issue:7

    Topics: Animals; Bile Acids and Salts; Cholestasis; Cholic Acid; Cholic Acids; Glycine; Humans; Rats; Taurin

1984
Bile acid metabolism.
    Annual review of biochemistry, 1975, Volume: 44

    Topics: Animals; Bile Acids and Salts; Cholelithiasis; Cholestasis; Cholesterol; Diet; Glycine; Hormones; Hy

1975

Trials

1 trial available for glycine and Cholestasis

ArticleYear
Effect of ursodeoxycholic acid on bile acid profiles and intestinal detoxification machinery in primary biliary cirrhosis and health.
    Journal of hepatology, 2012, Volume: 57, Issue:1

    Topics: Adult; Bile Acids and Salts; Biliary Tract; Carrier Proteins; Cholagogues and Choleretics; Cholestas

2012

Other Studies

19 other studies available for glycine and Cholestasis

ArticleYear
Mitochondria protection as a mechanism underlying the hepatoprotective effects of glycine in cholestatic mice.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 97

    Topics: Animals; Antioxidants; Bile Acids and Salts; Biomarkers; Cholestasis; Collagen; Disease Models, Anim

2018
Use of tc-99m mebrofenin as a clinical probe to assess altered hepatobiliary transport: integration of in vitro, pharmacokinetic modeling, and simulation studies.
    Pharmaceutical research, 2008, Volume: 25, Issue:8

    Topics: Aniline Compounds; Animals; Bile; Biological Transport; Biological Transport, Active; Cell Membrane;

2008
Dietary glycine blunts liver injury after bile duct ligation in rats.
    World journal of gastroenterology, 2008, Oct-21, Volume: 14, Issue:39

    Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Calcium; Cells, Cultured; Chlorides; Cho

2008
Differential diagnostic value in hepatobiliary disease of serum conjugated bile acid concentrations and some routine liver tests assessed by discriminant analysis.
    Clinica chimica acta; international journal of clinical chemistry, 1983, Jan-24, Volume: 127, Issue:2

    Topics: Adolescent; Adult; Aged; Alkaline Phosphatase; Aspartate Aminotransferases; Bile Acids and Salts; Bi

1983
Action of renal vasodilators in dogs following acute biliary obstruction.
    The Journal of surgical research, 1984, Volume: 36, Issue:2

    Topics: Acetylcholine; Acute Disease; Angiotensin II; Animals; Bile; Bradykinin; Cholestasis; Diuresis; Dogs

1984
Rapid determination of glycine- and taurine-conjugated bile acids in human bile by high-performance liquid chromatography.
    Journal of chromatography, 1980, Feb-08, Volume: 181, Issue:2

    Topics: Bile; Bile Acids and Salts; Cholelithiasis; Cholestasis; Chromatography, High Pressure Liquid; Commo

1980
Pan-sulfation of bile salts markedly increases hydrophilicity and essentially abolishes self- and hetero-association with lecithin.
    Biochimica et biophysica acta, 1993, Aug-04, Volume: 1182, Issue:1

    Topics: Bile Acids and Salts; Cholestasis; Glycine; Humans; Hydrogen-Ion Concentration; Liver Diseases; Memb

1993
Ethinylestradiol treatment induces multiple canalicular membrane transport alterations in rat liver.
    The Journal of clinical investigation, 1993, Volume: 91, Issue:6

    Topics: Adenosine; Animals; Bile; Bile Canaliculi; Biological Transport; Blood Chemical Analysis; Body Weigh

1993
Alagille's syndrome. New manifestations.
    Clinical nuclear medicine, 1996, Volume: 21, Issue:2

    Topics: Alagille Syndrome; Aniline Compounds; Cholestasis; Gallbladder; Glycine; Heart; Humans; Imino Acids;

1996
Role of biliary scintigraphy in management of bile leak.
    Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology, 1997, Volume: 16, Issue:2

    Topics: Adult; Aniline Compounds; Bile; Biliary Fistula; Cholangiopancreatography, Endoscopic Retrograde; Ch

1997
Bile acids affect liver mitochondrial bioenergetics: possible relevance for cholestasis therapy.
    Toxicological sciences : an official journal of the Society of Toxicology, 2000, Volume: 57, Issue:1

    Topics: Adenosine Diphosphate; Animals; Bile Acids and Salts; Cell Membrane Permeability; Cholestasis; Energ

2000
Hepatobiliary scintigraphic findings in obstructed intrahepatic choledochal cyst before and after surgery.
    Clinical nuclear medicine, 2001, Volume: 26, Issue:4

    Topics: Anastomosis, Roux-en-Y; Aniline Compounds; Choledochal Cyst; Cholestasis; Glycine; Hepatectomy; Huma

2001
Active amino-acid and sugar uptake by gall bladder epithelium in dog, guinea-pig and man.
    Pflugers Archiv : European journal of physiology, 1975, Apr-02, Volume: 355, Issue:4

    Topics: Amino Acids; Animals; Biological Transport, Active; Cholestasis; Dinitrophenols; Dogs; Gallbladder;

1975
Altered glycine and taurine conjugation of bile acids following aluminum administration to rats.
    Journal of pediatric gastroenterology and nutrition, 1989, Volume: 9, Issue:3

    Topics: Aluminum; Animals; Bile Acids and Salts; Cholestasis; Glycine; Male; Rats; Rats, Inbred Strains; Tau

1989
[Significance of bile acid metabolism in the pathogenesis of surgical diseases].
    Bruns' Beitrage fur klinische Chirurgie, 1973, Volume: 220, Issue:1

    Topics: Bile Acids and Salts; Biliary Fistula; Blind Loop Syndrome; Cholelithiasis; Cholestasis; Cholesterol

1973
Serum bile acids in primary biliary cirrhosis.
    Gut, 1972, Volume: 13, Issue:3

    Topics: Bile Acids and Salts; Cholestasis; Cholestyramine Resin; Glycine; Humans; Hydroxylation; Liver Cirrh

1972
[Effect of hydrocortisone on the activity of plasma and hepatic tissue enzymes. I. Leucylaminopeptidase (LAP) and glycylaminopeptidase (GAP) activity in experimental liver cirrhosis and mechanical jaundice in rats].
    Przeglad lekarski, 1971, Volume: 28, Issue:12

    Topics: Aminopeptidases; Animals; Cholestasis; Glycine; Hydrocortisone; Leucyl Aminopeptidase; Liver; Liver

1971
Serum bile acids in liver disease.
    Gut, 1971, Volume: 12, Issue:2

    Topics: Adult; Aged; Bile Acids and Salts; Biliary Tract Diseases; Cholanes; Cholestasis; Colitis, Ulcerativ

1971
[On the behavior of the so-called leucine aminopeptidase (LAP) in the serum during the application of various substrates].
    Klinische Wochenschrift, 1968, May-15, Volume: 46, Issue:10

    Topics: Adolescent; Adult; Aged; Animals; Aspartate Aminotransferases; Biliary Tract Diseases; Cholestasis;

1968