glycine has been researched along with Cholestasis in 23 studies
Cholestasis: Impairment of bile flow due to obstruction in small bile ducts (INTRAHEPATIC CHOLESTASIS) or obstruction in large bile ducts (EXTRAHEPATIC CHOLESTASIS).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ursodeoxycholic acid (UDCA) exerts anticholestatic, antifibrotic and antiproliferative effects in primary biliary cirrhosis (PBC) via mechanisms not yet fully understood." | 9.16 | Effect of ursodeoxycholic acid on bile acid profiles and intestinal detoxification machinery in primary biliary cirrhosis and health. ( Bastiaansen, BA; Beuers, U; Dilger, K; Hohenester, S; Rust, C; Schaap, FG; Winkler-Budenhofer, U, 2012) |
| "Ursodeoxycholic acid (UDCA) exerts anticholestatic, antifibrotic and antiproliferative effects in primary biliary cirrhosis (PBC) via mechanisms not yet fully understood." | 5.16 | Effect of ursodeoxycholic acid on bile acid profiles and intestinal detoxification machinery in primary biliary cirrhosis and health. ( Bastiaansen, BA; Beuers, U; Dilger, K; Hohenester, S; Rust, C; Schaap, FG; Winkler-Budenhofer, U, 2012) |
| "Cholestasis is the stoppage of bile flow which could lead to serious clinical complications if not managed." | 1.48 | Mitochondria protection as a mechanism underlying the hepatoprotective effects of glycine in cholestatic mice. ( Abdoli, N; Aghaei, F; Ahmadi, A; Azarpira, N; Esfandiari, A; Ghanbarinejad, V; Heidari, R; Mohammadi, H; Niknahad, H; Ommati, MM, 2018) |
| " A pharmacokinetic model was developed based on blood, urine and bile concentration-time profiles obtained in healthy humans, and the effect of changes in hepatic uptake and/or excretion associated with disease states (hyperbilirubinemia and cholestasis) on MEB disposition was simulated." | 1.35 | Use of tc-99m mebrofenin as a clinical probe to assess altered hepatobiliary transport: integration of in vitro, pharmacokinetic modeling, and simulation studies. ( Brouwer, KL; Ghibellini, G; Leslie, EM; Pollack, GM, 2008) |
| "Subsequently, an obstructed choledochal cyst was diagnosed clinically, and a right hepatectomy followed by a Roux-en-Y loop implantation on the raw surface of the left lobe were performed." | 1.31 | Hepatobiliary scintigraphic findings in obstructed intrahepatic choledochal cyst before and after surgery. ( Agarwala, S; Choudhury, S; Dasan, B; Kumar, R; Malhotra, A, 2001) |
| "Glycine/taurine was greater in group II versus III and varied directly with serum bile acid concentration." | 1.28 | Altered glycine and taurine conjugation of bile acids following aluminum administration to rats. ( Heyman, MB; Klein, GL; Lee, TC; Rassin, DK, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (56.52) | 18.7374 |
| 1990's | 4 (17.39) | 18.2507 |
| 2000's | 4 (17.39) | 29.6817 |
| 2010's | 2 (8.70) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Heidari, R | 1 |
| Ghanbarinejad, V | 1 |
| Mohammadi, H | 1 |
| Ahmadi, A | 1 |
| Ommati, MM | 1 |
| Abdoli, N | 1 |
| Aghaei, F | 1 |
| Esfandiari, A | 1 |
| Azarpira, N | 1 |
| Niknahad, H | 1 |
| Ghibellini, G | 1 |
| Leslie, EM | 1 |
| Pollack, GM | 1 |
| Brouwer, KL | 1 |
| Froh, M | 1 |
| Zhong, Z | 1 |
| Walbrun, P | 1 |
| Lehnert, M | 1 |
| Netter, S | 1 |
| Wiest, R | 1 |
| Conzelmann, L | 1 |
| Gabele, E | 1 |
| Hellerbrand, C | 1 |
| Scholmerich, J | 1 |
| Thurman, RG | 1 |
| Dilger, K | 1 |
| Hohenester, S | 1 |
| Winkler-Budenhofer, U | 1 |
| Bastiaansen, BA | 1 |
| Schaap, FG | 1 |
| Rust, C | 1 |
| Beuers, U | 1 |
| Linnet, K | 1 |
| Andersen, JR | 1 |
| Hoshita, T | 1 |
| Yamanaka, M | 1 |
| Sano, N | 1 |
| Itokazu, K | 1 |
| Yokote, M | 1 |
| Levy, M | 1 |
| Finestone, H | 1 |
| Fechner, C | 1 |
| Miyazaki, S | 1 |
| Tanaka, H | 1 |
| Horikawa, R | 1 |
| Tsuchiya, H | 1 |
| Imai, K | 1 |
| Donovan, JM | 1 |
| Yousef, IM | 1 |
| Carey, MC | 1 |
| Bossard, R | 1 |
| Stieger, B | 1 |
| O'Neill, B | 1 |
| Fricker, G | 1 |
| Meier, PJ | 1 |
| Balich, S | 1 |
| Jarboe, GL | 1 |
| Stevens, JS | 1 |
| Khanduri, A | 1 |
| Agarwal, DK | 1 |
| Mittal, BR | 1 |
| Choudhuri, G | 1 |
| Rolo, AP | 1 |
| Oliveira, PJ | 1 |
| Moreno, AJ | 1 |
| Palmeira, CM | 1 |
| Kumar, R | 1 |
| Choudhury, S | 1 |
| Dasan, B | 1 |
| Agarwala, S | 1 |
| Malhotra, A | 1 |
| Danielsson, H | 1 |
| Sjövall, J | 1 |
| Mirkovitch, V | 1 |
| Sepúlveda, FV | 1 |
| Menge, H | 1 |
| Robinson, JW | 1 |
| Klein, GL | 1 |
| Lee, TC | 1 |
| Heyman, MB | 1 |
| Rassin, DK | 1 |
| Stremmel, W | 1 |
| Murphy, GM | 1 |
| Ross, A | 1 |
| Billing, BH | 1 |
| Drozdz, H | 1 |
| Neale, G | 1 |
| Lewis, B | 1 |
| Weaver, V | 1 |
| Panveliwalla, D | 1 |
| Brunner, G | 1 |
| Sommer, J | 1 |
| Kattermann, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| [NCT00529009] | Phase 1 | 0 participants | Interventional | 2007-05-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for glycine and Cholestasis
| Article | Year |
|---|---|
[Conjugation and deconjugation of bile acids].
Topics: Bile Acids and Salts; Cholestasis; Glucuronates; Glycine; Humans; Liver; Sulfuric Acids; Taurine | 1984 |
[Abnormal bile acids in obstructive jaundice].
Topics: Animals; Bile Acids and Salts; Cholestasis; Cholic Acid; Cholic Acids; Glycine; Humans; Rats; Taurin | 1984 |
Bile acid metabolism.
Topics: Animals; Bile Acids and Salts; Cholelithiasis; Cholestasis; Cholesterol; Diet; Glycine; Hormones; Hy | 1975 |
1 trial available for glycine and Cholestasis
| Article | Year |
|---|---|
Effect of ursodeoxycholic acid on bile acid profiles and intestinal detoxification machinery in primary biliary cirrhosis and health.
Topics: Adult; Bile Acids and Salts; Biliary Tract; Carrier Proteins; Cholagogues and Choleretics; Cholestas | 2012 |
19 other studies available for glycine and Cholestasis
| Article | Year |
|---|---|
Mitochondria protection as a mechanism underlying the hepatoprotective effects of glycine in cholestatic mice.
Topics: Animals; Antioxidants; Bile Acids and Salts; Biomarkers; Cholestasis; Collagen; Disease Models, Anim | 2018 |
Use of tc-99m mebrofenin as a clinical probe to assess altered hepatobiliary transport: integration of in vitro, pharmacokinetic modeling, and simulation studies.
Topics: Aniline Compounds; Animals; Bile; Biological Transport; Biological Transport, Active; Cell Membrane; | 2008 |
Dietary glycine blunts liver injury after bile duct ligation in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Calcium; Cells, Cultured; Chlorides; Cho | 2008 |
Differential diagnostic value in hepatobiliary disease of serum conjugated bile acid concentrations and some routine liver tests assessed by discriminant analysis.
Topics: Adolescent; Adult; Aged; Alkaline Phosphatase; Aspartate Aminotransferases; Bile Acids and Salts; Bi | 1983 |
Action of renal vasodilators in dogs following acute biliary obstruction.
Topics: Acetylcholine; Acute Disease; Angiotensin II; Animals; Bile; Bradykinin; Cholestasis; Diuresis; Dogs | 1984 |
Rapid determination of glycine- and taurine-conjugated bile acids in human bile by high-performance liquid chromatography.
Topics: Bile; Bile Acids and Salts; Cholelithiasis; Cholestasis; Chromatography, High Pressure Liquid; Commo | 1980 |
Pan-sulfation of bile salts markedly increases hydrophilicity and essentially abolishes self- and hetero-association with lecithin.
Topics: Bile Acids and Salts; Cholestasis; Glycine; Humans; Hydrogen-Ion Concentration; Liver Diseases; Memb | 1993 |
Ethinylestradiol treatment induces multiple canalicular membrane transport alterations in rat liver.
Topics: Adenosine; Animals; Bile; Bile Canaliculi; Biological Transport; Blood Chemical Analysis; Body Weigh | 1993 |
Alagille's syndrome. New manifestations.
Topics: Alagille Syndrome; Aniline Compounds; Cholestasis; Gallbladder; Glycine; Heart; Humans; Imino Acids; | 1996 |
Role of biliary scintigraphy in management of bile leak.
Topics: Adult; Aniline Compounds; Bile; Biliary Fistula; Cholangiopancreatography, Endoscopic Retrograde; Ch | 1997 |
Bile acids affect liver mitochondrial bioenergetics: possible relevance for cholestasis therapy.
Topics: Adenosine Diphosphate; Animals; Bile Acids and Salts; Cell Membrane Permeability; Cholestasis; Energ | 2000 |
Hepatobiliary scintigraphic findings in obstructed intrahepatic choledochal cyst before and after surgery.
Topics: Anastomosis, Roux-en-Y; Aniline Compounds; Choledochal Cyst; Cholestasis; Glycine; Hepatectomy; Huma | 2001 |
Active amino-acid and sugar uptake by gall bladder epithelium in dog, guinea-pig and man.
Topics: Amino Acids; Animals; Biological Transport, Active; Cholestasis; Dinitrophenols; Dogs; Gallbladder; | 1975 |
Altered glycine and taurine conjugation of bile acids following aluminum administration to rats.
Topics: Aluminum; Animals; Bile Acids and Salts; Cholestasis; Glycine; Male; Rats; Rats, Inbred Strains; Tau | 1989 |
[Significance of bile acid metabolism in the pathogenesis of surgical diseases].
Topics: Bile Acids and Salts; Biliary Fistula; Blind Loop Syndrome; Cholelithiasis; Cholestasis; Cholesterol | 1973 |
Serum bile acids in primary biliary cirrhosis.
Topics: Bile Acids and Salts; Cholestasis; Cholestyramine Resin; Glycine; Humans; Hydroxylation; Liver Cirrh | 1972 |
[Effect of hydrocortisone on the activity of plasma and hepatic tissue enzymes. I. Leucylaminopeptidase (LAP) and glycylaminopeptidase (GAP) activity in experimental liver cirrhosis and mechanical jaundice in rats].
Topics: Aminopeptidases; Animals; Cholestasis; Glycine; Hydrocortisone; Leucyl Aminopeptidase; Liver; Liver | 1971 |
Serum bile acids in liver disease.
Topics: Adult; Aged; Bile Acids and Salts; Biliary Tract Diseases; Cholanes; Cholestasis; Colitis, Ulcerativ | 1971 |
[On the behavior of the so-called leucine aminopeptidase (LAP) in the serum during the application of various substrates].
Topics: Adolescent; Adult; Aged; Animals; Aspartate Aminotransferases; Biliary Tract Diseases; Cholestasis; | 1968 |