glycine has been researched along with Cholestasis in 23 studies
Cholestasis: Impairment of bile flow due to obstruction in small bile ducts (INTRAHEPATIC CHOLESTASIS) or obstruction in large bile ducts (EXTRAHEPATIC CHOLESTASIS).
Excerpt | Relevance | Reference |
---|---|---|
"Ursodeoxycholic acid (UDCA) exerts anticholestatic, antifibrotic and antiproliferative effects in primary biliary cirrhosis (PBC) via mechanisms not yet fully understood." | 9.16 | Effect of ursodeoxycholic acid on bile acid profiles and intestinal detoxification machinery in primary biliary cirrhosis and health. ( Bastiaansen, BA; Beuers, U; Dilger, K; Hohenester, S; Rust, C; Schaap, FG; Winkler-Budenhofer, U, 2012) |
"Ursodeoxycholic acid (UDCA) exerts anticholestatic, antifibrotic and antiproliferative effects in primary biliary cirrhosis (PBC) via mechanisms not yet fully understood." | 5.16 | Effect of ursodeoxycholic acid on bile acid profiles and intestinal detoxification machinery in primary biliary cirrhosis and health. ( Bastiaansen, BA; Beuers, U; Dilger, K; Hohenester, S; Rust, C; Schaap, FG; Winkler-Budenhofer, U, 2012) |
"Cholestasis is the stoppage of bile flow which could lead to serious clinical complications if not managed." | 1.48 | Mitochondria protection as a mechanism underlying the hepatoprotective effects of glycine in cholestatic mice. ( Abdoli, N; Aghaei, F; Ahmadi, A; Azarpira, N; Esfandiari, A; Ghanbarinejad, V; Heidari, R; Mohammadi, H; Niknahad, H; Ommati, MM, 2018) |
" A pharmacokinetic model was developed based on blood, urine and bile concentration-time profiles obtained in healthy humans, and the effect of changes in hepatic uptake and/or excretion associated with disease states (hyperbilirubinemia and cholestasis) on MEB disposition was simulated." | 1.35 | Use of tc-99m mebrofenin as a clinical probe to assess altered hepatobiliary transport: integration of in vitro, pharmacokinetic modeling, and simulation studies. ( Brouwer, KL; Ghibellini, G; Leslie, EM; Pollack, GM, 2008) |
"Subsequently, an obstructed choledochal cyst was diagnosed clinically, and a right hepatectomy followed by a Roux-en-Y loop implantation on the raw surface of the left lobe were performed." | 1.31 | Hepatobiliary scintigraphic findings in obstructed intrahepatic choledochal cyst before and after surgery. ( Agarwala, S; Choudhury, S; Dasan, B; Kumar, R; Malhotra, A, 2001) |
"Glycine/taurine was greater in group II versus III and varied directly with serum bile acid concentration." | 1.28 | Altered glycine and taurine conjugation of bile acids following aluminum administration to rats. ( Heyman, MB; Klein, GL; Lee, TC; Rassin, DK, 1989) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 13 (56.52) | 18.7374 |
1990's | 4 (17.39) | 18.2507 |
2000's | 4 (17.39) | 29.6817 |
2010's | 2 (8.70) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Heidari, R | 1 |
Ghanbarinejad, V | 1 |
Mohammadi, H | 1 |
Ahmadi, A | 1 |
Ommati, MM | 1 |
Abdoli, N | 1 |
Aghaei, F | 1 |
Esfandiari, A | 1 |
Azarpira, N | 1 |
Niknahad, H | 1 |
Ghibellini, G | 1 |
Leslie, EM | 1 |
Pollack, GM | 1 |
Brouwer, KL | 1 |
Froh, M | 1 |
Zhong, Z | 1 |
Walbrun, P | 1 |
Lehnert, M | 1 |
Netter, S | 1 |
Wiest, R | 1 |
Conzelmann, L | 1 |
Gabele, E | 1 |
Hellerbrand, C | 1 |
Scholmerich, J | 1 |
Thurman, RG | 1 |
Dilger, K | 1 |
Hohenester, S | 1 |
Winkler-Budenhofer, U | 1 |
Bastiaansen, BA | 1 |
Schaap, FG | 1 |
Rust, C | 1 |
Beuers, U | 1 |
Linnet, K | 1 |
Andersen, JR | 1 |
Hoshita, T | 1 |
Yamanaka, M | 1 |
Sano, N | 1 |
Itokazu, K | 1 |
Yokote, M | 1 |
Levy, M | 1 |
Finestone, H | 1 |
Fechner, C | 1 |
Miyazaki, S | 1 |
Tanaka, H | 1 |
Horikawa, R | 1 |
Tsuchiya, H | 1 |
Imai, K | 1 |
Donovan, JM | 1 |
Yousef, IM | 1 |
Carey, MC | 1 |
Bossard, R | 1 |
Stieger, B | 1 |
O'Neill, B | 1 |
Fricker, G | 1 |
Meier, PJ | 1 |
Balich, S | 1 |
Jarboe, GL | 1 |
Stevens, JS | 1 |
Khanduri, A | 1 |
Agarwal, DK | 1 |
Mittal, BR | 1 |
Choudhuri, G | 1 |
Rolo, AP | 1 |
Oliveira, PJ | 1 |
Moreno, AJ | 1 |
Palmeira, CM | 1 |
Kumar, R | 1 |
Choudhury, S | 1 |
Dasan, B | 1 |
Agarwala, S | 1 |
Malhotra, A | 1 |
Danielsson, H | 1 |
Sjövall, J | 1 |
Mirkovitch, V | 1 |
Sepúlveda, FV | 1 |
Menge, H | 1 |
Robinson, JW | 1 |
Klein, GL | 1 |
Lee, TC | 1 |
Heyman, MB | 1 |
Rassin, DK | 1 |
Stremmel, W | 1 |
Murphy, GM | 1 |
Ross, A | 1 |
Billing, BH | 1 |
Drozdz, H | 1 |
Neale, G | 1 |
Lewis, B | 1 |
Weaver, V | 1 |
Panveliwalla, D | 1 |
Brunner, G | 1 |
Sommer, J | 1 |
Kattermann, R | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
[NCT00529009] | Phase 1 | 0 participants | Interventional | 2007-05-31 | Completed | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
3 reviews available for glycine and Cholestasis
Article | Year |
---|---|
[Conjugation and deconjugation of bile acids].
Topics: Bile Acids and Salts; Cholestasis; Glucuronates; Glycine; Humans; Liver; Sulfuric Acids; Taurine | 1984 |
[Abnormal bile acids in obstructive jaundice].
Topics: Animals; Bile Acids and Salts; Cholestasis; Cholic Acid; Cholic Acids; Glycine; Humans; Rats; Taurin | 1984 |
Bile acid metabolism.
Topics: Animals; Bile Acids and Salts; Cholelithiasis; Cholestasis; Cholesterol; Diet; Glycine; Hormones; Hy | 1975 |
1 trial available for glycine and Cholestasis
Article | Year |
---|---|
Effect of ursodeoxycholic acid on bile acid profiles and intestinal detoxification machinery in primary biliary cirrhosis and health.
Topics: Adult; Bile Acids and Salts; Biliary Tract; Carrier Proteins; Cholagogues and Choleretics; Cholestas | 2012 |
19 other studies available for glycine and Cholestasis
Article | Year |
---|---|
Mitochondria protection as a mechanism underlying the hepatoprotective effects of glycine in cholestatic mice.
Topics: Animals; Antioxidants; Bile Acids and Salts; Biomarkers; Cholestasis; Collagen; Disease Models, Anim | 2018 |
Use of tc-99m mebrofenin as a clinical probe to assess altered hepatobiliary transport: integration of in vitro, pharmacokinetic modeling, and simulation studies.
Topics: Aniline Compounds; Animals; Bile; Biological Transport; Biological Transport, Active; Cell Membrane; | 2008 |
Dietary glycine blunts liver injury after bile duct ligation in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Calcium; Cells, Cultured; Chlorides; Cho | 2008 |
Differential diagnostic value in hepatobiliary disease of serum conjugated bile acid concentrations and some routine liver tests assessed by discriminant analysis.
Topics: Adolescent; Adult; Aged; Alkaline Phosphatase; Aspartate Aminotransferases; Bile Acids and Salts; Bi | 1983 |
Action of renal vasodilators in dogs following acute biliary obstruction.
Topics: Acetylcholine; Acute Disease; Angiotensin II; Animals; Bile; Bradykinin; Cholestasis; Diuresis; Dogs | 1984 |
Rapid determination of glycine- and taurine-conjugated bile acids in human bile by high-performance liquid chromatography.
Topics: Bile; Bile Acids and Salts; Cholelithiasis; Cholestasis; Chromatography, High Pressure Liquid; Commo | 1980 |
Pan-sulfation of bile salts markedly increases hydrophilicity and essentially abolishes self- and hetero-association with lecithin.
Topics: Bile Acids and Salts; Cholestasis; Glycine; Humans; Hydrogen-Ion Concentration; Liver Diseases; Memb | 1993 |
Ethinylestradiol treatment induces multiple canalicular membrane transport alterations in rat liver.
Topics: Adenosine; Animals; Bile; Bile Canaliculi; Biological Transport; Blood Chemical Analysis; Body Weigh | 1993 |
Alagille's syndrome. New manifestations.
Topics: Alagille Syndrome; Aniline Compounds; Cholestasis; Gallbladder; Glycine; Heart; Humans; Imino Acids; | 1996 |
Role of biliary scintigraphy in management of bile leak.
Topics: Adult; Aniline Compounds; Bile; Biliary Fistula; Cholangiopancreatography, Endoscopic Retrograde; Ch | 1997 |
Bile acids affect liver mitochondrial bioenergetics: possible relevance for cholestasis therapy.
Topics: Adenosine Diphosphate; Animals; Bile Acids and Salts; Cell Membrane Permeability; Cholestasis; Energ | 2000 |
Hepatobiliary scintigraphic findings in obstructed intrahepatic choledochal cyst before and after surgery.
Topics: Anastomosis, Roux-en-Y; Aniline Compounds; Choledochal Cyst; Cholestasis; Glycine; Hepatectomy; Huma | 2001 |
Active amino-acid and sugar uptake by gall bladder epithelium in dog, guinea-pig and man.
Topics: Amino Acids; Animals; Biological Transport, Active; Cholestasis; Dinitrophenols; Dogs; Gallbladder; | 1975 |
Altered glycine and taurine conjugation of bile acids following aluminum administration to rats.
Topics: Aluminum; Animals; Bile Acids and Salts; Cholestasis; Glycine; Male; Rats; Rats, Inbred Strains; Tau | 1989 |
[Significance of bile acid metabolism in the pathogenesis of surgical diseases].
Topics: Bile Acids and Salts; Biliary Fistula; Blind Loop Syndrome; Cholelithiasis; Cholestasis; Cholesterol | 1973 |
Serum bile acids in primary biliary cirrhosis.
Topics: Bile Acids and Salts; Cholestasis; Cholestyramine Resin; Glycine; Humans; Hydroxylation; Liver Cirrh | 1972 |
[Effect of hydrocortisone on the activity of plasma and hepatic tissue enzymes. I. Leucylaminopeptidase (LAP) and glycylaminopeptidase (GAP) activity in experimental liver cirrhosis and mechanical jaundice in rats].
Topics: Aminopeptidases; Animals; Cholestasis; Glycine; Hydrocortisone; Leucyl Aminopeptidase; Liver; Liver | 1971 |
Serum bile acids in liver disease.
Topics: Adult; Aged; Bile Acids and Salts; Biliary Tract Diseases; Cholanes; Cholestasis; Colitis, Ulcerativ | 1971 |
[On the behavior of the so-called leucine aminopeptidase (LAP) in the serum during the application of various substrates].
Topics: Adolescent; Adult; Aged; Animals; Aspartate Aminotransferases; Biliary Tract Diseases; Cholestasis; | 1968 |