glycine has been researched along with Cell Transformation, Neoplastic in 35 studies
Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Here, we demonstrate in an in vivo transgenic model in which atorvastatin reverses and prevents the onset of MYC-induced lymphomagenesis, but fails to reverse or prevent tumorigenesis in the presence of constitutively activated K-Ras (G12D)." | 7.74 | Inhibition of HMGcoA reductase by atorvastatin prevents and reverses MYC-induced lymphomagenesis. ( Chang, M; Chen, J; Elchuri, S; Fan, AC; Felsher, DW; Goldstein, MJ; Mitchell, DJ; Nolan, GP; Perez, OD; Shachaf, CM; Sharpe, O; Shirer, AE; Steinman, L; Youssef, S, 2007) |
| " Here, we demonstrate in an in vivo transgenic model in which atorvastatin reverses and prevents the onset of MYC-induced lymphomagenesis, but fails to reverse or prevent tumorigenesis in the presence of constitutively activated K-Ras (G12D)." | 3.74 | Inhibition of HMGcoA reductase by atorvastatin prevents and reverses MYC-induced lymphomagenesis. ( Chang, M; Chen, J; Elchuri, S; Fan, AC; Felsher, DW; Goldstein, MJ; Mitchell, DJ; Nolan, GP; Perez, OD; Shachaf, CM; Sharpe, O; Shirer, AE; Steinman, L; Youssef, S, 2007) |
| "The Arg388 allele increased prostate cancer risk compared with Gly388 allele (OR = 1." | 2.47 | FGFR4 Gly388Arg polymorphism contributes to prostate cancer development and progression: a meta-analysis of 2618 cases and 2305 controls. ( Chen, M; Chen, SQ; Hua, LX; Tong, N; Wang, ZJ; Xu, B; Zhang, ZD, 2011) |
| "Furthermore, hematologic malignancies arising in NrasG12D/G12D,C181S compound heterozygous mice invariably acquired revertant mutations that restored cysteine 181." | 1.56 | Genetic disruption of N-RasG12D palmitoylation perturbs hematopoiesis and prevents myeloid transformation in mice. ( Cravatt, BF; Firestone, AJ; Haigis, KM; Huang, BJ; Inguva, A; Kogan, SC; Long, AM; Predovic, M; Remsberg, JR; Shannon, K; Suciu, RM; Wong, JC; Zambetti, NA, 2020) |
| "TICs from primary NSCLC tumors express high levels of the oncogenic stem cell factor LIN28B and GLDC, which are both required for TIC growth and tumorigenesis." | 1.38 | Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis. ( Ahmed, DA; Ang, HS; Bhakoo, KK; Jayapal, SR; Kaldis, P; Lim, B; Lim, EH; Ma, S; Mitchell, W; Nga, ME; Nichane, M; Noghabi, MS; Pang, YH; Rai, A; Robson, P; Shyh-Chang, N; Sing, WP; Soh, BS; Soo, RA; Sun, LL; Swarup, S; Tai, BC; Tam, J; Tan, C; Thirugananam, A; Umashankar, S; Yang, H; Yu, Q; Zhang, WC, 2012) |
| "In two ulcerative colitis patients, a mutation was found in the Ki-ras gene (Gly --> Asp 12 and Gly --> Val 12), and in one patient, a mutation in exon 5 of the p53 gene." | 1.30 | Detection of Ki-ras mutations by PCR and differential hybridization and of p53 mutations by SSCP analysis in endoscopically obtained lavage solution from patients with long-standing ulcerative colitis. ( Heinzlmann, M; Lang, SM; Loeschke, K; Stratakis, DF; Teschauer, W, 1997) |
| "Five glycine resonances were identified with residues near the nucleotide binding site and provide useful reporters of several oncogene-activating positions." | 1.28 | Identification of resonances from an oncogenic activating locus of human N-RAS-encoded p21 protein using isotope-edited NMR. ( Burk, SC; McCormick, F; Papastavros, MZ; Redfield, AG, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (28.57) | 18.7374 |
| 1990's | 6 (17.14) | 18.2507 |
| 2000's | 8 (22.86) | 29.6817 |
| 2010's | 9 (25.71) | 24.3611 |
| 2020's | 2 (5.71) | 2.80 |
| Authors | Studies |
|---|---|
| Huo, FC | 1 |
| Xie, M | 1 |
| Zhu, ZM | 1 |
| Zheng, JN | 1 |
| Pei, DS | 1 |
| Pizzato Scomazzon, S | 1 |
| Riccio, A | 1 |
| Santopolo, S | 1 |
| Lanzilli, G | 1 |
| Coccia, M | 1 |
| Rossi, A | 1 |
| Santoro, MG | 1 |
| Zambetti, NA | 1 |
| Firestone, AJ | 1 |
| Remsberg, JR | 1 |
| Huang, BJ | 1 |
| Wong, JC | 1 |
| Long, AM | 1 |
| Predovic, M | 1 |
| Suciu, RM | 1 |
| Inguva, A | 1 |
| Kogan, SC | 1 |
| Haigis, KM | 1 |
| Cravatt, BF | 1 |
| Shannon, K | 1 |
| Sachs, Z | 1 |
| LaRue, RS | 1 |
| Nguyen, HT | 1 |
| Sachs, K | 1 |
| Noble, KE | 1 |
| Mohd Hassan, NA | 1 |
| Diaz-Flores, E | 1 |
| Rathe, SK | 1 |
| Sarver, AL | 1 |
| Bendall, SC | 1 |
| Ha, NA | 1 |
| Diers, MD | 1 |
| Nolan, GP | 2 |
| Shannon, KM | 1 |
| Largaespada, DA | 1 |
| Athuluri-Divakar, SK | 1 |
| Vasquez-Del Carpio, R | 1 |
| Dutta, K | 1 |
| Baker, SJ | 1 |
| Cosenza, SC | 1 |
| Basu, I | 1 |
| Gupta, YK | 1 |
| Reddy, MV | 1 |
| Ueno, L | 1 |
| Hart, JR | 1 |
| Vogt, PK | 1 |
| Mulholland, D | 1 |
| Guha, C | 1 |
| Aggarwal, AK | 1 |
| Reddy, EP | 1 |
| Kottakis, F | 1 |
| Nicolay, BN | 1 |
| Roumane, A | 1 |
| Karnik, R | 1 |
| Gu, H | 1 |
| Nagle, JM | 1 |
| Boukhali, M | 1 |
| Hayward, MC | 1 |
| Li, YY | 1 |
| Chen, T | 1 |
| Liesa, M | 1 |
| Hammerman, PS | 1 |
| Wong, KK | 1 |
| Hayes, DN | 1 |
| Shirihai, OS | 1 |
| Dyson, NJ | 1 |
| Haas, W | 1 |
| Meissner, A | 1 |
| Bardeesy, N | 1 |
| Ray, KC | 1 |
| Bell, KM | 1 |
| Yan, J | 1 |
| Gu, G | 1 |
| Chung, CH | 1 |
| Washington, MK | 1 |
| Means, AL | 1 |
| Xu, B | 1 |
| Tong, N | 1 |
| Chen, SQ | 1 |
| Hua, LX | 1 |
| Wang, ZJ | 1 |
| Zhang, ZD | 1 |
| Chen, M | 1 |
| Zhang, WC | 1 |
| Shyh-Chang, N | 1 |
| Yang, H | 1 |
| Rai, A | 1 |
| Umashankar, S | 1 |
| Ma, S | 1 |
| Soh, BS | 1 |
| Sun, LL | 1 |
| Tai, BC | 1 |
| Nga, ME | 1 |
| Bhakoo, KK | 1 |
| Jayapal, SR | 1 |
| Nichane, M | 1 |
| Yu, Q | 1 |
| Ahmed, DA | 1 |
| Tan, C | 1 |
| Sing, WP | 1 |
| Tam, J | 1 |
| Thirugananam, A | 1 |
| Noghabi, MS | 1 |
| Pang, YH | 1 |
| Ang, HS | 1 |
| Mitchell, W | 1 |
| Robson, P | 1 |
| Kaldis, P | 1 |
| Soo, RA | 1 |
| Swarup, S | 1 |
| Lim, EH | 1 |
| Lim, B | 1 |
| Jain, M | 1 |
| Nilsson, R | 1 |
| Sharma, S | 1 |
| Madhusudhan, N | 1 |
| Kitami, T | 1 |
| Souza, AL | 1 |
| Kafri, R | 1 |
| Kirschner, MW | 1 |
| Clish, CB | 1 |
| Mootha, VK | 1 |
| Wei, SJ | 1 |
| Trempus, CS | 1 |
| Ali, RC | 1 |
| Hansen, LA | 1 |
| Tennant, RW | 1 |
| Reagan-Shaw, S | 1 |
| Ahmad, N | 1 |
| Kupumbati, TS | 1 |
| Cattoretti, G | 1 |
| Marzan, C | 1 |
| Farias, EF | 1 |
| Taneja, R | 1 |
| Mira-y-Lopez, R | 1 |
| Gu, J | 1 |
| Wu, X | 1 |
| Dong, Q | 1 |
| Romeo, MJ | 1 |
| Lin, X | 1 |
| Gutkind, JS | 1 |
| Berman, DM | 1 |
| Stamp, D | 1 |
| Caulin, C | 1 |
| Nguyen, T | 1 |
| Lang, GA | 1 |
| Goepfert, TM | 1 |
| Brinkley, BR | 1 |
| Cai, WW | 1 |
| Lozano, G | 1 |
| Roop, DR | 1 |
| Shachaf, CM | 1 |
| Perez, OD | 1 |
| Youssef, S | 1 |
| Fan, AC | 1 |
| Elchuri, S | 1 |
| Goldstein, MJ | 1 |
| Shirer, AE | 1 |
| Sharpe, O | 1 |
| Chen, J | 2 |
| Mitchell, DJ | 1 |
| Chang, M | 1 |
| Steinman, L | 1 |
| Felsher, DW | 1 |
| Eccleston, JF | 1 |
| Moore, KJ | 1 |
| Morgan, L | 1 |
| Skinner, RH | 1 |
| Lowe, PN | 1 |
| Hanafusa, T | 1 |
| Wang, LH | 1 |
| Lang, SM | 1 |
| Heinzlmann, M | 1 |
| Stratakis, DF | 1 |
| Teschauer, W | 1 |
| Loeschke, K | 1 |
| Austen, M | 1 |
| Cerni, C | 1 |
| Lüscher-Firzlaff, JM | 1 |
| Lüscher, B | 1 |
| Kasper, LH | 1 |
| Brindle, PK | 1 |
| Schnabel, CA | 1 |
| Pritchard, CE | 1 |
| Cleary, ML | 1 |
| van Deursen, JM | 1 |
| Rose, ML | 1 |
| Rivera, CA | 1 |
| Bradford, BU | 1 |
| Graves, LM | 1 |
| Cattley, RC | 1 |
| Schoonhoven, R | 1 |
| Swenberg, JA | 1 |
| Thurman, RG | 1 |
| Chen, CC | 1 |
| Tseng, TH | 1 |
| Hsu, JD | 1 |
| Wang, CJ | 1 |
| Cecchini, G | 1 |
| Lee, M | 1 |
| Oxender, DL | 1 |
| Burk, SC | 1 |
| Papastavros, MZ | 1 |
| McCormick, F | 2 |
| Redfield, AG | 1 |
| Niu, CH | 1 |
| Han, KH | 1 |
| Roller, PP | 1 |
| Kamps, MP | 1 |
| Buss, JE | 1 |
| Sefton, BM | 1 |
| Clark, R | 1 |
| Wong, G | 1 |
| Arnheim, N | 1 |
| Nitecki, D | 1 |
| Parodi, S | 1 |
| Furlani, A | 1 |
| Scarcia, V | 1 |
| Cavanna, M | 1 |
| Brambilla, G | 1 |
| Marin, G | 1 |
| Littlefield, JW | 1 |
| Hladká, M | 1 |
| Altaner, C | 1 |
| Oronsky, AL | 1 |
| Nocenti, MR | 1 |
| Veselá, H | 1 |
| Kraus, P | 1 |
| Semonský, M | 1 |
| Slavíková, V | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase III, International, Randomized, Controlled Study of Rigosertib Versus Physician's Choice of Treatment in Patients With Myelodysplastic Syndrome After Failure of a Hypomethylating Agent[NCT02562443] | Phase 3 | 372 participants (Actual) | Interventional | 2015-12-02 | Terminated (stopped due to Top line analysis indicated that the study had failed to achieve its primary endpoint.) | ||
| Phase III MultiCenter Randomized Controlled Study to Assess Efficacy and Safety of ON 01910.Na 72-Hr Continuous IV Infusion in MDS Patients With Excess Blasts Relapsing After or Refractory to or Intolerant to Azacitidine or Decitabine[NCT01241500] | Phase 3 | 299 participants (Actual) | Interventional | 2010-11-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for glycine and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
FGFR4 Gly388Arg polymorphism contributes to prostate cancer development and progression: a meta-analysis of 2618 cases and 2305 controls.
Topics: Amino Acid Substitution; Arginine; Biomarkers, Tumor; Carcinoma; Case-Control Studies; Cell Transfor | 2011 |
Polo-like kinase (Plk) 1 as a target for prostate cancer management.
Topics: Animals; Antibodies; Antineoplastic Agents; Cell Cycle Proteins; Cell Line, Tumor; Cell Transformati | 2005 |
33 other studies available for glycine and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
SHMT2 promotes the tumorigenesis of renal cell carcinoma by regulating the m6A modification of PPAT.
Topics: Amidophosphoribosyltransferase; Carbon; Carcinogenesis; Carcinoma, Renal Cell; Cell Proliferation; C | 2022 |
The Zinc-Finger AN1-Type Domain 2a Gene Acts as a Regulator of Cell Survival in Human Melanoma: Role of E3-Ligase cIAP2.
Topics: Baculoviral IAP Repeat-Containing 3 Protein; Boron Compounds; Bortezomib; Cell Line, Tumor; Cell Tra | 2019 |
Genetic disruption of N-RasG12D palmitoylation perturbs hematopoiesis and prevents myeloid transformation in mice.
Topics: Amino Acid Substitution; Animals; Aspartic Acid; Cell Transformation, Neoplastic; Cells, Cultured; G | 2020 |
NRASG12V oncogene facilitates self-renewal in a murine model of acute myelogenous leukemia.
Topics: Amino Acid Substitution; Animals; Cell Proliferation; Cell Transformation, Neoplastic; Disease Model | 2014 |
[In Process Citation].
Topics: Alanine; Amino Acid Substitution; Cell Transformation, Neoplastic; DNA Mutational Analysis; Glycine; | 2015 |
A Small Molecule RAS-Mimetic Disrupts RAS Association with Effector Proteins to Block Signaling.
Topics: Amino Acid Sequence; Animals; Cell Cycle Proteins; Cell Transformation, Neoplastic; Crystallography, | 2016 |
A Small Molecule RAS-Mimetic Disrupts RAS Association with Effector Proteins to Block Signaling.
Topics: Amino Acid Sequence; Animals; Cell Cycle Proteins; Cell Transformation, Neoplastic; Crystallography, | 2016 |
A Small Molecule RAS-Mimetic Disrupts RAS Association with Effector Proteins to Block Signaling.
Topics: Amino Acid Sequence; Animals; Cell Cycle Proteins; Cell Transformation, Neoplastic; Crystallography, | 2016 |
A Small Molecule RAS-Mimetic Disrupts RAS Association with Effector Proteins to Block Signaling.
Topics: Amino Acid Sequence; Animals; Cell Cycle Proteins; Cell Transformation, Neoplastic; Crystallography, | 2016 |
LKB1 loss links serine metabolism to DNA methylation and tumorigenesis.
Topics: AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Animals; Cell Culture Technique | 2016 |
Epithelial tissues have varying degrees of susceptibility to Kras(G12D)-initiated tumorigenesis in a mouse model.
Topics: Amino Acid Substitution; Animals; Aspartic Acid; Carcinoma in Situ; Carcinoma, Pancreatic Ductal; Ce | 2011 |
Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis.
Topics: Amino Acid Sequence; Antigens, CD; Carcinoma, Non-Small-Cell Lung; Cell Adhesion Molecules, Neuronal | 2012 |
Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation.
Topics: Breast Neoplasms; Cell Cycle; Cell Line; Cell Line, Tumor; Cell Proliferation; Cell Transformation, | 2012 |
12-O-tetradecanoylphorbol-13-acetate and UV radiation-induced nucleoside diphosphate protein kinase B mediates neoplastic transformation of epidermal cells.
Topics: Animals; Antigens, CD34; Arginine; Aspartic Acid; Cell Transformation, Neoplastic; Cells, Cultured; | 2004 |
Dominant negative retinoic acid receptor initiates tumor formation in mice.
Topics: Animals; Breast Neoplasms; Cell Transformation, Neoplastic; Disease Models, Animal; Epithelial Cells | 2006 |
A nonsynonymous single-nucleotide polymorphism in the PDZ-Rho guanine nucleotide exchange factor (Ser1416Gly) modulates the risk of lung cancer in Mexican Americans.
Topics: Aged; Alleles; Case-Control Studies; Cell Transformation, Neoplastic; Cyclin D1; DNA, Neoplasm; Fema | 2006 |
Glycine conjugated and free bile acids, aided by acid suppression, can easily enter the esophageal epithelium where they can activate oncogenes and eventually carcinogenesis.
Topics: Barrett Esophagus; Bile Acids and Salts; Cell Transformation, Neoplastic; Epithelial Cells; Esophage | 2007 |
An inducible mouse model for skin cancer reveals distinct roles for gain- and loss-of-function p53 mutations.
Topics: Alleles; Aneuploidy; Animals; Arginine; Cell Transformation, Neoplastic; Centrosome; Disease Models, | 2007 |
Inhibition of HMGcoA reductase by atorvastatin prevents and reverses MYC-induced lymphomagenesis.
Topics: Animals; Atorvastatin; Cell Survival; Cell Transformation, Neoplastic; Cells, Cultured; Flow Cytomet | 2007 |
Kinetics of interaction between normal and proline 12 Ras and the GTPase-activating proteins, p120-GAP and neurofibromin. The significance of the intrinsic GTPase rate in determining the transforming ability of ras.
Topics: Cell Transformation, Neoplastic; Genes, ras; Glycine; GTP Phosphohydrolases; GTPase-Activating Prote | 1993 |
Ala-->Gly mutation in the putative catalytic loop confers temperature sensitivity on Ros, insulin receptor, and insulin-like growth factor I receptor protein-tyrosine kinases.
Topics: Alanine; Amino Acid Sequence; Base Sequence; Cell Transformation, Neoplastic; DNA Primers; Glycine; | 1994 |
Detection of Ki-ras mutations by PCR and differential hybridization and of p53 mutations by SSCP analysis in endoscopically obtained lavage solution from patients with long-standing ulcerative colitis.
Topics: Aspartic Acid; Biopsy; Case-Control Studies; Cell Transformation, Neoplastic; Codon; Colitis, Ulcera | 1997 |
YY1 can inhibit c-Myc function through a mechanism requiring DNA binding of YY1 but neither its transactivation domain nor direct interaction with c-Myc.
Topics: Alanine; Animals; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Basic-Leucine Zipper | 1998 |
CREB binding protein interacts with nucleoporin-specific FG repeats that activate transcription and mediate NUP98-HOXA9 oncogenicity.
Topics: 3T3 Cells; Animals; Artificial Gene Fusion; Cell Transformation, Neoplastic; CREB-Binding Protein; D | 1999 |
Kupffer cell oxidant production is central to the mechanism of peroxisome proliferators.
Topics: Animals; Calcium Signaling; Cell Division; Cell Transformation, Neoplastic; Diet; Diethylhexyl Phtha | 1999 |
Tumor-promoting effect of GGN-MRP extract from the Maillard reaction products of glucose and glycine in the presence of sodium nitrite in C3H10T1/2 cells.
Topics: Animals; Cell Division; Cell Line; Cell Transformation, Neoplastic; Glucose; Glycine; Maillard React | 2001 |
Transport of amino acids in intact 3T3 and SV3T3 cells. Binding activity for leucine in membrane preparations of ehrlich ascites tumor cells.
Topics: Animals; Binding Sites; Biological Transport, Active; Carcinoma, Ehrlich Tumor; Cell Line; Cell Memb | 1976 |
Identification of resonances from an oncogenic activating locus of human N-RAS-encoded p21 protein using isotope-edited NMR.
Topics: Carbon Isotopes; Cell Transformation, Neoplastic; Escherichia coli; Genes, ras; Glycine; Humans; Mag | 1989 |
Comparison of the conformation and GTP hydrolysing ability of N-terminal ras p21 protein segments.
Topics: Adenosine Triphosphate; Amino Acid Sequence; Cell Transformation, Neoplastic; Circular Dichroism; Gl | 1989 |
Mutation of NH2-terminal glycine of p60src prevents both myristoylation and morphological transformation.
Topics: Animals; Avian Sarcoma Viruses; Cell Transformation, Neoplastic; Chick Embryo; Glycine; Mutation; My | 1985 |
Antibodies specific for amino acid 12 of the ras oncogene product inhibit GTP binding.
Topics: Amino Acid Sequence; Antibodies; Cell Transformation, Neoplastic; Glycine; Guanosine Triphosphate; H | 1985 |
A new pharmacological method of host conditioning in order to facilitate in vivo growth of fibroblast-like cells cultivated in vitro.
Topics: Animals; Asparaginase; Azo Compounds; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; F | 1974 |
Selection of morphologically normal cell lines from polyoma-transformed BHK21/13 hamster fibroblasts.
Topics: Aminopterin; Animals; Bromodeoxyuridine; Cell Line; Cell Transformation, Neoplastic; Chromosome Aber | 1968 |
Suppression of the avian sarcoma virus genome in hamster-transformed cells made resistant to 8-azaguanine.
Topics: Animals; Antigens, Viral; Avian Sarcoma Viruses; Azaguanine; Carbon Radioisotopes; Cell Division; Ce | 1974 |
Influence of glucocortical hormone and actinomycin D on the uptake of labeled amino acids in granulomas.
Topics: Adrenalectomy; Amino Acids; Animals; Carbon Isotopes; Cell Transformation, Neoplastic; Dactinomycin; | 1972 |
Substances with antineoplastic effect. XLII. The influence of MBA on incorporation of some amino-acids in the proteins of Yoshida ascites rat sarcoma cells.
Topics: Acrylates; Amino Acids; Animals; Antineoplastic Agents; Autoradiography; Carbon Isotopes; Cell Trans | 1970 |