glycine has been researched along with Cataract in 34 studies
Cataract: Partial or complete opacity on or in the lens or capsule of one or both eyes, impairing vision or causing blindness. The many kinds of cataract are classified by their morphology (size, shape, location) or etiology (cause and time of occurrence). (Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The purpose of this paper was to investigate the effect of the oral administration of L-glycine (Gly) on the development of diabetic cataract induced by streptozotocin (STZ) in rats." | 7.78 | Glycine therapy inhibits the progression of cataract in streptozotocin-induced diabetic rats. ( Aldavood, SJ; Bahmani, F; Bathaie, SZ; Ghahghaei, A, 2012) |
| "The amino acid lysine has been reported to delay cataractogenesis by 'some unknown mechanism'." | 7.68 | Decrease in glycation of lens proteins by lysine and glycine by scavenging of glucose and possible mitigation of cataractogenesis. ( Ramakrishnan, S; Sulochana, KN, 1993) |
| "Glycine treatment increased body weight gain, reduced blood glucose, and increased plasma insulin levels compared to diabetic control rats, and also increased GSH content and decreased mRNA and protein levels of aldose reductase compared to their respective controls." | 5.51 | Protective effect of glycine in streptozotocin-induced diabetic cataract through aldose reductase inhibitory activity. ( Li, W; Shao, N; Zhang, Y, 2019) |
| "Isovaleric acidaemia was diagnosed in a 9-year-old girl with an unusual clinical presentation." | 5.26 | Isovaleric acidaemia presenting with dwarfism, cataract and congenital abnormalities. ( Batenburg-Plenter, AM; Bruinvis, L; Duran, M; Ketting, D; van Pelt, BC; Wadman, SK, 1982) |
| "The purpose of this paper was to investigate the effect of the oral administration of L-glycine (Gly) on the development of diabetic cataract induced by streptozotocin (STZ) in rats." | 3.78 | Glycine therapy inhibits the progression of cataract in streptozotocin-induced diabetic rats. ( Aldavood, SJ; Bahmani, F; Bathaie, SZ; Ghahghaei, A, 2012) |
| "The objective of this study is to understand the molecular basis of cataract that develops due to the mutation of the glycine-98 residue to arginine in alphaA-crystallin." | 3.73 | The cataract-causing mutation G98R in human alphaA-crystallin leads to folding defects and loss of chaperone activity. ( Ramakrishna, T; Raman, B; Rao, ChM; Singh, D, 2006) |
| "The amino acid lysine has been reported to delay cataractogenesis by 'some unknown mechanism'." | 3.68 | Decrease in glycation of lens proteins by lysine and glycine by scavenging of glucose and possible mitigation of cataractogenesis. ( Ramakrishnan, S; Sulochana, KN, 1993) |
| "There was a gradual decrease in the quantity of various amino acids associated with cataract formation due to reduced concentrations of glutamic acid, threonine, serine, glycine, alanine, leucine, isoleucine, phenylalanine and tyrosine in stages of cataract formation." | 3.67 | Study of the relationship between free amino acids and cataract in human lenses. ( Bhatnagar, R; Chauhan, BS; Desai, NC; Garg, SP, 1984) |
| "Glycine treatment increased body weight gain, reduced blood glucose, and increased plasma insulin levels compared to diabetic control rats, and also increased GSH content and decreased mRNA and protein levels of aldose reductase compared to their respective controls." | 1.51 | Protective effect of glycine in streptozotocin-induced diabetic cataract through aldose reductase inhibitory activity. ( Li, W; Shao, N; Zhang, Y, 2019) |
| "Congenital cataract is a leading cause of visual disability in children." | 1.32 | Characterization of the G91del CRYBA1/3-crystallin protein: a cause of human inherited cataract. ( Bateman, OA; Berry, V; Bhattacharya, SS; Chakarova, C; Ferris, J; Lomas, E; Moore, AT; Reddy, MA; Sarra, R; Slingsby, C; Smith, MA, 2004) |
| "Isovaleric acidaemia was diagnosed in a 9-year-old girl with an unusual clinical presentation." | 1.26 | Isovaleric acidaemia presenting with dwarfism, cataract and congenital abnormalities. ( Batenburg-Plenter, AM; Bruinvis, L; Duran, M; Ketting, D; van Pelt, BC; Wadman, SK, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (41.18) | 18.7374 |
| 1990's | 3 (8.82) | 18.2507 |
| 2000's | 8 (23.53) | 29.6817 |
| 2010's | 8 (23.53) | 24.3611 |
| 2020's | 1 (2.94) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, H | 1 |
| Tian, Q | 1 |
| Xu, J | 1 |
| Xu, W | 1 |
| Yao, K | 1 |
| Chen, X | 1 |
| Takahashi, G | 1 |
| Hasegawa, S | 1 |
| Fukutomi, Y | 1 |
| Harada, C | 1 |
| Furugori, M | 1 |
| Seki, Y | 1 |
| Kikkawa, Y | 1 |
| Wada, K | 1 |
| Li, W | 1 |
| Zhang, Y | 1 |
| Shao, N | 1 |
| López-Lera, A | 1 |
| Torres-Canizales, JM | 1 |
| Garrido, S | 1 |
| Morales, A | 1 |
| López-Trascasa, M | 1 |
| DiMauro, MA | 1 |
| Nandi, SK | 1 |
| Raghavan, CT | 1 |
| Kar, RK | 1 |
| Wang, B | 1 |
| Bhunia, A | 1 |
| Nagaraj, RH | 1 |
| Biswas, A | 1 |
| Mohebi, M | 1 |
| Akbari, A | 1 |
| Babaei, N | 1 |
| Sadeghi, A | 1 |
| Heidari, M | 1 |
| Ma, X | 2 |
| Li, FF | 1 |
| Wang, SZ | 1 |
| Gao, C | 2 |
| Zhang, M | 2 |
| Zhu, SQ | 1 |
| Zhou, G | 1 |
| Zhou, N | 1 |
| Hu, S | 1 |
| Zhao, L | 1 |
| Zhang, C | 1 |
| Qi, Y | 1 |
| Raju, M | 1 |
| Santhoshkumar, P | 1 |
| Sharma, KK | 1 |
| Bahmani, F | 1 |
| Bathaie, SZ | 1 |
| Aldavood, SJ | 1 |
| Ghahghaei, A | 1 |
| Yang, C | 1 |
| Hou, S | 1 |
| Wang, X | 1 |
| Luo, J | 1 |
| Reddy, MA | 1 |
| Bateman, OA | 1 |
| Chakarova, C | 1 |
| Ferris, J | 1 |
| Berry, V | 1 |
| Lomas, E | 1 |
| Sarra, R | 1 |
| Smith, MA | 1 |
| Moore, AT | 1 |
| Bhattacharya, SS | 1 |
| Slingsby, C | 1 |
| Sastre, J | 1 |
| Martín, JA | 1 |
| Gómez-Cabrera, MC | 1 |
| Pereda, J | 1 |
| Borrás, C | 1 |
| Pallardó, FV | 1 |
| Viña, J | 1 |
| Santhiya, ST | 1 |
| Soker, T | 1 |
| Klopp, N | 1 |
| Illig, T | 1 |
| Prakash, MV | 1 |
| Selvaraj, B | 1 |
| Gopinath, PM | 1 |
| Graw, J | 1 |
| Singh, D | 1 |
| Raman, B | 1 |
| Ramakrishna, T | 1 |
| Rao, ChM | 1 |
| Li, F | 1 |
| Wang, S | 1 |
| Liu, S | 1 |
| Zhao, B | 1 |
| Huang, S | 1 |
| Zhu, S | 1 |
| Adams, CW | 1 |
| Nance, WE | 1 |
| Chauhan, BS | 1 |
| Desai, NC | 1 |
| Bhatnagar, R | 1 |
| Garg, SP | 1 |
| Duran, M | 1 |
| Bruinvis, L | 1 |
| Ketting, D | 1 |
| Wadman, SK | 1 |
| van Pelt, BC | 1 |
| Batenburg-Plenter, AM | 1 |
| Ramakrishnan, S | 1 |
| Sulochana, KN | 1 |
| Körkkö, J | 1 |
| Ritvaniemi, P | 1 |
| Haataja, L | 1 |
| Kääriäinen, H | 1 |
| Kivirikko, KI | 1 |
| Prockop, DJ | 1 |
| Ala-Kokko, L | 1 |
| Holleschau, AM | 1 |
| Rathbun, WB | 1 |
| Nagasawa, HT | 1 |
| Bilska, A | 1 |
| Włodek, L | 1 |
| Rowe, VD | 1 |
| Zigler, S | 1 |
| Andersen, AE | 1 |
| Sidbury, JB | 1 |
| Guroff, G | 1 |
| Reddy, VN | 1 |
| Similä, S | 1 |
| Käär, ML | 1 |
| Harris, JE | 1 |
| Gruber, L | 1 |
| Imaizumi, K | 3 |
| Atsumi, K | 2 |
| Tanaka, J | 1 |
| Hatano, M | 2 |
| Imaizumi, S | 2 |
| Hiwatari, S | 1 |
| Graeber, W | 1 |
| Ogawa, K | 1 |
| Other, A | 1 |
| Bartsocas, CS | 1 |
| Levy, HL | 1 |
| Crawford, JD | 1 |
| Thier, SO | 1 |
2 reviews available for glycine and Cataract
| Article | Year |
|---|---|
[Biologic properties of lipoic acid].
Topics: Acquired Immunodeficiency Syndrome; Aging; Animals; Antioxidants; Cataract; Decarboxylation; Diabeti | 2002 |
Metabolism of glutathione in the lens.
Topics: Alcohol Oxidoreductases; Amino Acids; Animals; Aqueous Humor; Cataract; Cell Membrane Permeability; | 1971 |
2 trials available for glycine and Cataract
| Article | Year |
|---|---|
[Effects of Thiola eye drop in senile cataract].
Topics: Age Factors; Aged; Animals; Cataract; Clinical Trials as Topic; Glycine; Humans; Lens, Crystalline; | 1971 |
[Thiola tablet, a senile cataract inhibitor].
Topics: Cataract; Glycine; Humans; Placebos; Propionates; Sulfhydryl Compounds; Tablets; Visual Acuity | 1970 |
30 other studies available for glycine and Cataract
| Article | Year |
|---|---|
Cataract-causing G91del mutant destabilised βA3 heteromers formation linking with structural stability and cellular viability.
Topics: beta-Crystallin A Chain; Cataract; Crystallins; Glycine; Guanidine; Humans; Lens, Crystalline | 2022 |
A novel missense mutation of Mip causes semi-dominant cataracts in the Nat mouse.
Topics: Amino Acid Substitution; Animals; Aquaporins; Arginine; Cataract; Eye Proteins; Genetic Association | 2017 |
Protective effect of glycine in streptozotocin-induced diabetic cataract through aldose reductase inhibitory activity.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Cataract; Diabetes Complications; Diabetes | 2019 |
Rothmund-Thomson syndrome and glomerulonephritis in a homozygous C1q-deficient patient due to a Gly164Ser C1qC mutation.
Topics: Adult; Cataract; Cohort Studies; Complement C1q; Erythema; Exons; Glomerulonephritis; Glycine; Homoz | 2014 |
Acetylation of Gly1 and Lys2 promotes aggregation of human γD-crystallin.
Topics: Acetylation; Aged; Aging; Amino Acid Sequence; Cataract; gamma-Crystallins; Glycine; Humans; Lysine; | 2014 |
Identification of a De Novo 3bp Deletion in CRYBA1/A3 Gene in Autosomal Dominant Congenital Cataract.
Topics: Adult; Asian People; Base Sequence; beta-Crystallin A Chain; beta-Crystallin B Chain; Cataract; Chil | 2016 |
A new mutation in BFSP2 (G1091A) causes autosomal dominant congenital lamellar cataracts.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Base Sequence; Cataract; Child; Chromatograph | 2008 |
A missense mutation in CRYBA4 associated with congenital cataract and microcornea.
Topics: Adolescent; Adult; Amino Acid Substitution; Base Sequence; beta-Crystallin A Chain; Cataract; Child; | 2010 |
Cataract-causing αAG98R-crystallin mutant dissociates into monomers having chaperone activity.
Topics: alpha-Crystallins; Arginine; Cataract; Chromatography; Chromatography, Gel; Genes, Dominant; Glycine | 2011 |
Glycine therapy inhibits the progression of cataract in streptozotocin-induced diabetic rats.
Topics: Administration, Oral; Aldehyde Reductase; Animals; Catalase; Cataract; Crystallins; Diabetes Mellitu | 2012 |
[Chemical constituents of grub and grub eye drops].
Topics: Amino Acids; Animals; Cataract; Coleoptera; Corneal Opacity; Glutamic Acid; Glycine; Materia Medica; | 2000 |
Characterization of the G91del CRYBA1/3-crystallin protein: a cause of human inherited cataract.
Topics: Amino Acid Sequence; beta-Crystallin A Chain; Cataract; Crystallins; Female; Genes, Dominant; Geneti | 2004 |
Age-associated oxidative damage leads to absence of gamma-cystathionase in over 50% of rat lenses: relevance in cataractogenesis.
Topics: Aging; Alkynes; Animals; Cataract; Cystathionine gamma-Lyase; Glutathione; Glycine; Lens, Crystallin | 2005 |
Identification of a novel, putative cataract-causing allele in CRYAA (G98R) in an Indian family.
Topics: Adult; alpha-Crystallin A Chain; Arginine; Asian People; Cataract; Disease Progression; Female; Gene | 2006 |
The cataract-causing mutation G98R in human alphaA-crystallin leads to folding defects and loss of chaperone activity.
Topics: alpha-Crystallin A Chain; Arginine; Cataract; Circular Dichroism; Escherichia coli; Glycine; Humans; | 2006 |
Mutation G61C in the CRYGD gene causing autosomal dominant congenital coralliform cataracts.
Topics: Adult; Amino Acid Sequence; Base Sequence; Cataract; Chromatography, High Pressure Liquid; Chromosom | 2008 |
Persistent tachycardia, paroxymal hypertension, and seizures: association with hyperglycinuria, dominantly inherited microphthalmia, and cataracts.
Topics: Adult; Amino Acid Metabolism, Inborn Errors; Amino Acids; Cataract; Female; Glycine; Humans; Hyperte | 1967 |
Study of the relationship between free amino acids and cataract in human lenses.
Topics: Adult; Aged; Alanine; Amino Acids; Cataract; Glutamates; Glutamic Acid; Glycine; Humans; Lens, Cryst | 1984 |
Isovaleric acidaemia presenting with dwarfism, cataract and congenital abnormalities.
Topics: Abnormalities, Multiple; Amino Acid Metabolism, Inborn Errors; Cataract; Child; Dwarfism; Female; Gl | 1982 |
Decrease in glycation of lens proteins by lysine and glycine by scavenging of glucose and possible mitigation of cataractogenesis.
Topics: Animals; Cataract; Crystallins; Glucose; Glycine; Glycosylation; Goats; Humans; Hydrogen-Ion Concent | 1993 |
Mutation in type II procollagen (COL2A1) that substitutes aspartate for glycine alpha 1-67 and that causes cataracts and retinal detachment: evidence for molecular heterogeneity in the Wagner syndrome and the Stickler syndrome (arthro-ophthalmopathy)
Topics: Adolescent; Adult; Amino Acid Sequence; Aspartic Acid; Base Sequence; Cataract; Child; Child, Presch | 1993 |
An HPLC radiotracer method for assessing the ability of L-cysteine prodrugs to maintain glutathione levels in the cultured rat lens.
Topics: Animals; Carbon Radioisotopes; Cataract; Chromatography, High Pressure Liquid; Cysteine; Dipeptides; | 1996 |
Some characteristics of the p-chlorophenylalanine-induced cataract.
Topics: Amino Acids; Animals; Arginine; Aspartic Acid; Cataract; Chromatography, Gas; Crystallins; Electroph | 1973 |
Hyperglycinuria in a family with autosomal dominantly inherited cataract.
Topics: Cataract; Child, Preschool; Chromosome Aberrations; Chromosome Disorders; Creatinine; Electrophoresi | 1974 |
The reversal of triparanol-induced cataracts in the rat. 3. Amino acid content and uptake of 14 C -AIB in cataractous and clearing lenses.
Topics: Alanine; Amino Acids; Aminoisobutyric Acids; Animals; Arginine; Aspartic Acid; Carbon Isotopes; Cata | 1973 |
[A study on etiology and treatment of cataract].
Topics: Adult; Aged; Amino Acids; Animals; Cataract; Diabetes Complications; Female; Glycine; Humans; Hypopa | 1973 |
[Medical treatment of senile cataract. A clinical appraisal].
Topics: Age Factors; Aged; Alanine Transaminase; Alkaline Phosphatase; Antidotes; Aspartate Aminotransferase | 1971 |
[The amino acid composition of human lens proteins in the course of lens alterations and cataract transformation. I. The amino acid composition of unclouded human lenses of various age groups].
Topics: Adult; Age Factors; Aged; Aging; Alanine; Amino Acids; Arginine; Asparagine; Cataract; Crystallins; | 1966 |
Congenital cataract, mental retardation and amino-aciduria. Amino-acid excretion determined by high-voltage electrophoresis in patients with mental retardation and congenital cataract.
Topics: Amino Acid Metabolism, Inborn Errors; Amino Acids; Biological Transport; Cataract; Electrophoresis; | 1968 |
A defect in intestinal amino acid transport in Lowe's syndrome.
Topics: Adult; Arginine; Biopsy; Carbon Isotopes; Cataract; Child, Preschool; Glaucoma; Glycine; Humans; Int | 1969 |