glycine has been researched along with Carcinoma, Non-Small Cell Lung in 19 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pemetrexed represents the first antifolate cancer drug to be approved by the Food and Drug Administration in 20 years; it is currently in widespread use for first line therapy of mesothelioma and non-small cell lung cancer." | 3.75 | Therapeutics by cytotoxic metabolite accumulation: pemetrexed causes ZMP accumulation, AMPK activation, and mammalian target of rapamycin inhibition. ( Heyer, CL; Moran, RG; Racanelli, AC; Rothbart, SB, 2009) |
| "Ixazomib treatment resulted in significant metabolic regulation, and some of these changes were specific to KRAS WT tumors." | 1.42 | KRAS Genotype Correlates with Proteasome Inhibitor Ixazomib Activity in Preclinical In Vivo Models of Colon and Non-Small Cell Lung Cancer: Potential Role of Tumor Metabolism. ( Amidon, B; Bannerman, B; Berger, AJ; Bernard, H; Chattopadhyay, N; Donelan, J; Galvin, K; Garnsey, J; Hales, P; Hather, G; Jordan, K; Koenig, E; Maldonado Lopez, A; Manfredi, M; Rhodes, N; Stringer, B; Tirrell, S; Xia, C; Yang, Y, 2015) |
| "TICs from primary NSCLC tumors express high levels of the oncogenic stem cell factor LIN28B and GLDC, which are both required for TIC growth and tumorigenesis." | 1.38 | Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis. ( Ahmed, DA; Ang, HS; Bhakoo, KK; Jayapal, SR; Kaldis, P; Lim, B; Lim, EH; Ma, S; Mitchell, W; Nga, ME; Nichane, M; Noghabi, MS; Pang, YH; Rai, A; Robson, P; Shyh-Chang, N; Sing, WP; Soh, BS; Soo, RA; Sun, LL; Swarup, S; Tai, BC; Tam, J; Tan, C; Thirugananam, A; Umashankar, S; Yang, H; Yu, Q; Zhang, WC, 2012) |
| "Glioblastomas and brain metastases demonstrate avid uptake of 2-[(18) F]fluoro-2-deoxyglucose by positron emission tomography and display perturbations of intracellular metabolite pools by (1) H MRS." | 1.38 | Metabolism of [U-13 C]glucose in human brain tumors in vivo. ( Bachoo, RM; Choi, C; DeBerardinis, RJ; Hatanpaa, KJ; Jeffrey, FM; Jindal, A; Madden, C; Maher, EA; Malloy, CR; Marin-Valencia, I; Mashimo, T; Mathews, D; Mickey, BE; Pascual, JM; Raisanen, J, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (10.53) | 18.2507 |
| 2000's | 5 (26.32) | 29.6817 |
| 2010's | 10 (52.63) | 24.3611 |
| 2020's | 2 (10.53) | 2.80 |
| Authors | Studies |
|---|---|
| Azuma, K | 1 |
| Xiang, H | 1 |
| Tagami, T | 1 |
| Kasajima, R | 1 |
| Kato, Y | 1 |
| Karakawa, S | 1 |
| Kikuchi, S | 1 |
| Imaizumi, A | 1 |
| Matsuo, N | 1 |
| Ishii, H | 1 |
| Tokito, T | 1 |
| Kawahara, A | 1 |
| Murotani, K | 1 |
| Sasada, T | 1 |
| Miyagi, Y | 1 |
| Hoshino, T | 1 |
| Gul, K | 1 |
| Zaman, N | 1 |
| Azam, SS | 1 |
| Kazemi, Z | 1 |
| Zahmatkesh, MH | 1 |
| Abedi, SM | 1 |
| Hosseinimehr, SJ | 1 |
| Zhang, Y | 1 |
| Meng, L | 1 |
| Li, B | 1 |
| Tan, H | 1 |
| Lin, QY | 1 |
| Cheng, D | 1 |
| Shi, H | 1 |
| Bouras, N | 1 |
| Bousahba, A | 1 |
| Megaïz, A | 1 |
| de Fraipont, F | 1 |
| Sahraoui, T | 1 |
| Kebir, FZE | 1 |
| Ito, H | 1 |
| Nakayama, H | 1 |
| Yokose, T | 1 |
| Yamada, K | 1 |
| Chattopadhyay, N | 1 |
| Berger, AJ | 1 |
| Koenig, E | 1 |
| Bannerman, B | 1 |
| Garnsey, J | 1 |
| Bernard, H | 1 |
| Hales, P | 1 |
| Maldonado Lopez, A | 1 |
| Yang, Y | 1 |
| Donelan, J | 1 |
| Jordan, K | 1 |
| Tirrell, S | 1 |
| Stringer, B | 1 |
| Xia, C | 1 |
| Hather, G | 1 |
| Galvin, K | 1 |
| Manfredi, M | 1 |
| Rhodes, N | 1 |
| Amidon, B | 1 |
| Riscal, R | 1 |
| Schrepfer, E | 1 |
| Arena, G | 1 |
| Cissé, MY | 1 |
| Bellvert, F | 1 |
| Heuillet, M | 1 |
| Rambow, F | 1 |
| Bonneil, E | 1 |
| Sabourdy, F | 1 |
| Vincent, C | 1 |
| Ait-Arsa, I | 1 |
| Levade, T | 1 |
| Thibaut, P | 1 |
| Marine, JC | 1 |
| Portais, JC | 1 |
| Sarry, JE | 1 |
| Le Cam, L | 1 |
| Linares, LK | 1 |
| Caiola, E | 1 |
| Brunelli, L | 1 |
| Marabese, M | 1 |
| Broggini, M | 1 |
| Lupi, M | 1 |
| Pastorelli, R | 1 |
| Racanelli, AC | 1 |
| Rothbart, SB | 1 |
| Heyer, CL | 1 |
| Moran, RG | 1 |
| Zhang, WC | 1 |
| Shyh-Chang, N | 1 |
| Yang, H | 1 |
| Rai, A | 1 |
| Umashankar, S | 1 |
| Ma, S | 1 |
| Soh, BS | 1 |
| Sun, LL | 1 |
| Tai, BC | 1 |
| Nga, ME | 1 |
| Bhakoo, KK | 1 |
| Jayapal, SR | 1 |
| Nichane, M | 1 |
| Yu, Q | 1 |
| Ahmed, DA | 1 |
| Tan, C | 1 |
| Sing, WP | 1 |
| Tam, J | 1 |
| Thirugananam, A | 1 |
| Noghabi, MS | 1 |
| Pang, YH | 1 |
| Ang, HS | 1 |
| Mitchell, W | 1 |
| Robson, P | 1 |
| Kaldis, P | 1 |
| Soo, RA | 1 |
| Swarup, S | 1 |
| Lim, EH | 1 |
| Lim, B | 1 |
| Ihle, NT | 1 |
| Byers, LA | 1 |
| Kim, ES | 1 |
| Saintigny, P | 1 |
| Lee, JJ | 1 |
| Blumenschein, GR | 1 |
| Tsao, A | 1 |
| Liu, S | 1 |
| Larsen, JE | 1 |
| Wang, J | 1 |
| Diao, L | 1 |
| Coombes, KR | 1 |
| Chen, L | 1 |
| Zhang, S | 1 |
| Abdelmelek, MF | 1 |
| Tang, X | 1 |
| Papadimitrakopoulou, V | 1 |
| Minna, JD | 1 |
| Lippman, SM | 1 |
| Hong, WK | 1 |
| Herbst, RS | 1 |
| Wistuba, II | 1 |
| Heymach, JV | 1 |
| Powis, G | 1 |
| Maher, EA | 1 |
| Marin-Valencia, I | 1 |
| Bachoo, RM | 1 |
| Mashimo, T | 1 |
| Raisanen, J | 1 |
| Hatanpaa, KJ | 1 |
| Jindal, A | 1 |
| Jeffrey, FM | 1 |
| Choi, C | 1 |
| Madden, C | 1 |
| Mathews, D | 1 |
| Pascual, JM | 1 |
| Mickey, BE | 1 |
| Malloy, CR | 1 |
| DeBerardinis, RJ | 1 |
| Tanaka, E | 1 |
| Yamashita, J | 2 |
| Hayashi, N | 1 |
| Kato, S | 1 |
| Kondo, K | 1 |
| Ogawa, M | 3 |
| Schroeder, PE | 1 |
| Jensen, PB | 1 |
| Sehested, M | 1 |
| Hofland, KF | 1 |
| Langer, SW | 1 |
| Hasinoff, BB | 1 |
| Koh, TJ | 1 |
| Field, JK | 1 |
| Varro, A | 1 |
| Liloglou, T | 1 |
| Fielding, P | 1 |
| Cui, G | 1 |
| Houghton, J | 1 |
| Dockray, GJ | 1 |
| Wang, TC | 1 |
| Matakidou, A | 1 |
| El Galta, R | 1 |
| Rudd, MF | 1 |
| Webb, EL | 1 |
| Bridle, H | 1 |
| Eisen, T | 1 |
| Houlston, RS | 1 |
| Inada, M | 1 |
| Matsumura, F | 1 |
| Yamaguchi, Y | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Genotyping K-RAS and EGFR in Greek Non-small-cell Lung Cancer Patients: Incidence, Significance and Treatment Implications[NCT03951233] | 424 participants (Actual) | Observational | 2000-03-31 | Completed | |||
| Treatment Development of Triheptanoin for Glucose Transporter Type I Deficiency[NCT02021526] | Phase 1/Phase 2 | 0 participants (Actual) | Interventional | 2015-12-31 | Withdrawn (stopped due to NIH funding resulted in new clinical trial) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for glycine and Carcinoma, Non-Small Cell Lung
| Article | Year |
|---|---|
Prophylaxis for acute exacerbation of interstitial pneumonia after lung resection.
Topics: Aged; Aged, 80 and over; Anesthesia, General; Carcinoma, Non-Small-Cell Lung; Drug Administration Sc | 2014 |
18 other studies available for glycine and Carcinoma, Non-Small Cell Lung
| Article | Year |
|---|---|
Clinical significance of plasma-free amino acids and tryptophan metabolites in patients with non-small cell lung cancer receiving PD-1 inhibitor: a pilot cohort study for developing a prognostic multivariate model.
Topics: Amino Acids; Arginine; Carcinoma, Non-Small-Cell Lung; Glycine; Humans; Immune Checkpoint Inhibitors | 2022 |
Roxadustat and its failure: A comparative dynamic study.
Topics: Carcinoma, Non-Small-Cell Lung; Glycine; Humans; Hypoxia-Inducible Factor-Proline Dioxygenases; Isoq | 2023 |
Biological Evaluation of 99mTc-HYNIC-EDDA/tricine-(Ser)-D4 Peptide for Tumor Targeting.
Topics: Animals; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Chromatography, High Pressure Liquid; Chr | 2017 |
Preliminary application of micro-SPECT/CT imaging by
Topics: Animals; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Edetic Acid; Glycine; Humans; Hydrazines; | 2019 |
[In silico study of a functional mutation associated with non-small cell lung cancer: G12D mutation of exon 2 in KRAS gene].
Topics: Algeria; Amino Acid Substitution; Aspartic Acid; Carcinoma, Non-Small-Cell Lung; Computational Biolo | 2019 |
KRAS Genotype Correlates with Proteasome Inhibitor Ixazomib Activity in Preclinical In Vivo Models of Colon and Non-Small Cell Lung Cancer: Potential Role of Tumor Metabolism.
Topics: Amino Acids; Animals; Antineoplastic Agents; Boron Compounds; Carcinoma, Non-Small-Cell Lung; Cell L | 2015 |
Chromatin-Bound MDM2 Regulates Serine Metabolism and Redox Homeostasis Independently of p53.
Topics: Activating Transcription Factor 4; Animals; Carcinoma, Non-Small-Cell Lung; Carrier Proteins; Cell P | 2016 |
Different metabolic responses to PI3K inhibition in NSCLC cells harboring wild-type and G12C mutant KRAS.
Topics: Amino Acid Substitution; Carcinoma, Non-Small-Cell Lung; Cells, Cultured; Cysteine; Glycine; Humans; | 2016 |
Therapeutics by cytotoxic metabolite accumulation: pemetrexed causes ZMP accumulation, AMPK activation, and mammalian target of rapamycin inhibition.
Topics: Adenylate Kinase; Aminoimidazole Carboxamide; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; | 2009 |
Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis.
Topics: Amino Acid Sequence; Antigens, CD; Carcinoma, Non-Small-Cell Lung; Cell Adhesion Molecules, Neuronal | 2012 |
Effect of KRAS oncogene substitutions on protein behavior: implications for signaling and clinical outcome.
Topics: Aspartic Acid; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Clinical Trials, Phase II as Topic; | 2012 |
Metabolism of [U-13 C]glucose in human brain tumors in vivo.
Topics: Acetyl Coenzyme A; Blood Glucose; Brain Neoplasms; Breast Neoplasms; Carbon Isotopes; Carcinoma, Non | 2012 |
A pulmonary metastatic model of human non-small cell lung carcinoma cells that produce a neutrophil elastase-like molecule in severe combined immunodeficiency mice.
Topics: Animals; Carcinoma, Non-Small-Cell Lung; Disease Models, Animal; Female; Glycine; Immunohistochemist | 2003 |
Metabolism of dexrazoxane (ICRF-187) used as a rescue agent in cancer patients treated with high-dose etoposide.
Topics: Aged; Antineoplastic Agents, Phytogenic; Brain Neoplasms; Carcinoma, Non-Small-Cell Lung; Chemothera | 2003 |
Glycine-extended gastrin promotes the growth of lung cancer.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Animals; Carcinoma, Non-Small-Cell Lung; Carcinoma, | 2004 |
Further observations on the relationship between the FGFR4 Gly388Arg polymorphism and lung cancer prognosis.
Topics: Amino Acid Substitution; Arginine; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Combined M | 2007 |
Neutrophil elastase inhibitor (ONO-5046-Na) inhibits the growth of human lung cancer cell lines transplanted into severe combined immunodeficiency (scid) mice.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous | 1997 |
Adhesion molecule expression in vascular endothelial cells incubated with cancer cell line supernatant are inhibited by neutrophil elastase inhibitor (ONO-5046.Na).
Topics: Animals; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Endothelium, Vascular; Glycine; H | 1997 |