glycine has been researched along with Brain Neoplasms in 47 studies
Brain Neoplasms: Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We measured glycine, 2-hydroxyglutarate (2HG), and other tumor-related metabolites in 35 glioma patients using an MRS sequence tailored for co-detection of glycine and 2HG in gadolinium-enhancing and non-enhancing tumor regions on 3T MRI." | 7.96 | Glycine by MR spectroscopy is an imaging biomarker of glioma aggressiveness. ( An, Z; Askari, P; Baxter, J; Choi, C; Daoud, EV; DeBerardinis, RJ; Dimitrov, I; Ganji, SK; Gao, A; Hatanpaa, KJ; Levy, M; Lewis, CM; Madden, CJ; Maher, EA; Malloy, CR; Mickey, BE; Pan, E; Patel, TR; Pinho, MC; Raisanen, JM; Sherry, AD; Thomas, BP; Tiwari, V; Zhang, S, 2020) |
| "Human neuroblastoma SK-N-SH-SY5Y (5Y) and rat glioma (C6) cells were cultured with supplemental methionine, glycine, or serine for three to six days." | 7.66 | Effect of methionine, glycine and serine on serine hydroxymethyltransferase activity in rat glioma and human neuroblastoma cells. ( Kohl, RL; Perez-Polo, JR; Quay, WB, 1980) |
| "In 66 patients with advanced gliomas, ivosidenib was well tolerated, with no dose-limiting toxicities reported." | 5.34 | Ivosidenib in Isocitrate Dehydrogenase 1 ( Bowden, C; Burris, H; Choe, S; Cloughesy, TF; Cote, GM; De La Fuente, MI; Ellingson, BM; Fan, B; Holdhoff, M; Huang, R; Janku, F; Jiang, L; Lu, M; Maher, E; Mellinghoff, IK; Pandya, SS; Steelman, L; Touat, M; Wen, PY; Yen, K; Young, RJ, 2020) |
| "Gliotoxins are a group of amino acids that are toxic to astrocytes, and are substrates of high-affinity sodium-dependent glutamate transporters." | 5.32 | Gliotoxins disrupt alanine metabolism and glutathione production in C6 glioma cells: a 13C NMR spectroscopic study. ( Brennan, L; Hewage, C; Malthouse, JP; McBean, GJ, 2004) |
| " Here, we find that serine and glycine levels were higher in low-nutrient regions of tumors in glioblastoma multiforme (GBM) patients than they were in other regions." | 4.02 | Glioma cells require one-carbon metabolism to survive glutamine starvation. ( Bamba, T; Fujita, Y; Hashiguchi, M; Hosoda, K; Irino, Y; Izumi, Y; Kitta, A; Kohmura, E; Kohta, M; Kyotani, K; Nagashima, H; Nakai, T; Sasayama, T; Satoh, N; Shinohara, M; Takahashi, M; Tanaka, K; Uno, T; Uozumi, Y, 2021) |
| "We measured glycine, 2-hydroxyglutarate (2HG), and other tumor-related metabolites in 35 glioma patients using an MRS sequence tailored for co-detection of glycine and 2HG in gadolinium-enhancing and non-enhancing tumor regions on 3T MRI." | 3.96 | Glycine by MR spectroscopy is an imaging biomarker of glioma aggressiveness. ( An, Z; Askari, P; Baxter, J; Choi, C; Daoud, EV; DeBerardinis, RJ; Dimitrov, I; Ganji, SK; Gao, A; Hatanpaa, KJ; Levy, M; Lewis, CM; Madden, CJ; Maher, EA; Malloy, CR; Mickey, BE; Pan, E; Patel, TR; Pinho, MC; Raisanen, JM; Sherry, AD; Thomas, BP; Tiwari, V; Zhang, S, 2020) |
| "5-Benzylglycinyl-amiloride (UCD38B) is the parent molecule of a class of anticancer small molecules that kill proliferative and nonproliferative high-grade glioma cells by programmed necrosis." | 3.81 | Mis-trafficking of endosomal urokinase proteins triggers drug-induced glioma nonapoptotic cell death. ( Gorin, F; Grodzki, AC; Pasupuleti, N, 2015) |
| "55 ppm in a long echo time (TE) recognized as glycine (Gly) in the WHO grade II gliomas and central neurocytomas by means of 1H MRS." | 3.76 | Measurement of glycine in a brain and brain tumors by means of 1H MRS. ( Bobek-Billewicz, B; Hebda, A; Majchrzak, K; Stasik-Pres, G; Trojanowska, A; Zmuda, E, 2010) |
| " The 11C-labelled glycine thus prepared was used along with [68Ga]EDTA and L-[methyl-11C]methionine in the visualization of an anaplastic astrocytoma by positron emission tomography." | 3.67 | 11C-labelled glycine: synthesis and preliminary report on its use in the investigation of intracranial tumours using positron emission tomography. ( Bergström, M; Ericson, K; Johnström, P; Mosskin, M; Stone-Elander, S, 1987) |
| "Human neuroblastoma SK-N-SH-SY5Y (5Y) and rat glioma (C6) cells were cultured with supplemental methionine, glycine, or serine for three to six days." | 3.66 | Effect of methionine, glycine and serine on serine hydroxymethyltransferase activity in rat glioma and human neuroblastoma cells. ( Kohl, RL; Perez-Polo, JR; Quay, WB, 1980) |
| "H3." | 1.56 | Reciprocal H3.3 gene editing identifies K27M and G34R mechanisms in pediatric glioma including NOTCH signaling. ( Bush, K; Carcaboso, AM; Cervantes, V; Chen, KY; Klein, RH; Knoepfler, PS; Lechpammer, M; Lewis, N; Naqvi, A, 2020) |
| " Here, we report that RGS loaded in apolipoprotein E derived peptide (ApoE)-targeted chimaeric polymersomes (ApoE-CP) is safe and highly potent against human GBM in vivo." | 1.51 | Oncoprotein Inhibitor Rigosertib Loaded in ApoE-Targeted Smart Polymersomes Reveals High Safety and Potency against Human Glioblastoma in Mice. ( Deng, C; Jiang, Y; Qin, H; Zhang, J; Zhong, Z, 2019) |
| "Glycine (Gly) has been implicated in several neurological disorders, including malignant brain tumors." | 1.46 | Measurement of glycine in healthy and tumorous brain by triple-refocusing MRS at 3 T in vivo. ( An, Z; Baxter, J; Choi, C; Ganji, SK; Maher, EA; Mickey, BE; Pan, E; Patel, TR; Pinho, MC; Tiwari, V, 2017) |
| "Glycine was detected in 24% of all studies, though with a wide range of signal amplitude and extent of the spatial distributions." | 1.40 | Mapping of glycine distributions in gliomas. ( Behari, S; Gupta, RK; Hussain, N; Maudsley, AA; Parra, NA; Roy, B; Sheriff, S; Stoyanova, R, 2014) |
| "Glioblastomas and brain metastases demonstrate avid uptake of 2-[(18) F]fluoro-2-deoxyglucose by positron emission tomography and display perturbations of intracellular metabolite pools by (1) H MRS." | 1.38 | Metabolism of [U-13 C]glucose in human brain tumors in vivo. ( Bachoo, RM; Choi, C; DeBerardinis, RJ; Hatanpaa, KJ; Jeffrey, FM; Jindal, A; Madden, C; Maher, EA; Malloy, CR; Marin-Valencia, I; Mashimo, T; Mathews, D; Mickey, BE; Pascual, JM; Raisanen, J, 2012) |
| "Glycine is a key metabolic intermediate required for the synthesis of proteins, nucleic acids, and other molecules, and its detection in cancer could, therefore, provide biologically relevant information about the growth of the tumor." | 1.37 | Measurement of glycine in the human brain in vivo by 1H-MRS at 3 T: application in brain tumors. ( Bachoo, R; Choi, C; DeBerardinis, RJ; Dimitrov, IE; Ganji, SK; Maher, EA; Malloy, CR; Mickey, BE; Pascual, JM, 2011) |
| "Using 36 biopsies from patients with brain tumors [12 glioblastoma multiforme (GBM); 10 low-grade (LG), including 7 schwannoma and 3 pylocytic astrocytoma; 7 meningioma (MN); 7 brain metastases (MT), including 3 adenocarcinoma and 4 breast cancer] and 9 control biopsies from patients undergoing surgery for epilepsy, we tested the hypothesis that the presence of glycine may distinguish among these brain tumor types." | 1.36 | High-resolution magic angle spinning magnetic resonance spectroscopy detects glycine as a biomarker in brain tumors. ( Andronesi, OC; Black, PM; Mintzopoulos, D; Righi, V; Tzika, AA, 2010) |
| "Sulfasalazine was able to reduce glutathione levels in tumor tissue and slow tumor growth in vivo in a commonly used intracranial xenograft animal model for human gliomas when administered by intraperitoneal injection." | 1.33 | Inhibition of cystine uptake disrupts the growth of primary brain tumors. ( Chung, WJ; Gillespie, GY; Gladson, CL; Hamza, H; Lyons, SA; Nelson, GM; Sontheimer, H, 2005) |
| "Gliotoxins are a group of amino acids that are toxic to astrocytes, and are substrates of high-affinity sodium-dependent glutamate transporters." | 1.32 | Gliotoxins disrupt alanine metabolism and glutathione production in C6 glioma cells: a 13C NMR spectroscopic study. ( Brennan, L; Hewage, C; Malthouse, JP; McBean, GJ, 2004) |
| "Total creatine was decreased in all brain tumors in comparison with normal brain tissues, but was relatively higher in neuroectodermal tumors than in other brain tumors." | 1.29 | Proton magnetic resonance spectroscopy of brain tumors: an in vitro study. ( Kajiwara, H; Kinoshita, Y; Koga, Y; Yokota, A, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (8.51) | 18.7374 |
| 1990's | 7 (14.89) | 18.2507 |
| 2000's | 5 (10.64) | 29.6817 |
| 2010's | 20 (42.55) | 24.3611 |
| 2020's | 11 (23.40) | 2.80 |
| Authors | Studies |
|---|---|
| Sweha, SR | 1 |
| Chung, C | 1 |
| Natarajan, SK | 1 |
| Panwalkar, P | 1 |
| Pun, M | 1 |
| Ghali, A | 1 |
| Bayliss, J | 1 |
| Pratt, D | 1 |
| Shankar, A | 1 |
| Ravikumar, V | 1 |
| Rao, A | 1 |
| Cieslik, M | 1 |
| Wilder-Romans, K | 1 |
| Scott, AJ | 1 |
| Wahl, DR | 1 |
| Jessa, S | 1 |
| Kleinman, CL | 1 |
| Jabado, N | 1 |
| Mackay, A | 1 |
| Jones, C | 1 |
| Martinez, D | 1 |
| Santi, M | 1 |
| Judkins, AR | 1 |
| Yadav, VN | 1 |
| Qin, T | 1 |
| Phoenix, TN | 1 |
| Koschmann, CJ | 1 |
| Baker, SJ | 1 |
| Chinnaiyan, AM | 1 |
| Venneti, S | 1 |
| Ellingson, BM | 2 |
| Kim, GHJ | 1 |
| Brown, M | 1 |
| Lee, J | 1 |
| Salamon, N | 1 |
| Steelman, L | 2 |
| Hassan, I | 1 |
| Pandya, SS | 2 |
| Chun, S | 1 |
| Linetsky, M | 1 |
| Yoo, B | 1 |
| Wen, PY | 2 |
| Mellinghoff, IK | 2 |
| Goldin, J | 1 |
| Cloughesy, TF | 2 |
| Vuong, HG | 1 |
| Le, HT | 1 |
| Dunn, IF | 1 |
| Tiwari, V | 2 |
| Daoud, EV | 1 |
| Hatanpaa, KJ | 2 |
| Gao, A | 1 |
| Zhang, S | 1 |
| An, Z | 2 |
| Ganji, SK | 3 |
| Raisanen, JM | 1 |
| Lewis, CM | 1 |
| Askari, P | 1 |
| Baxter, J | 2 |
| Levy, M | 1 |
| Dimitrov, I | 1 |
| Thomas, BP | 1 |
| Pinho, MC | 2 |
| Madden, CJ | 1 |
| Pan, E | 2 |
| Patel, TR | 2 |
| DeBerardinis, RJ | 3 |
| Sherry, AD | 1 |
| Mickey, BE | 4 |
| Malloy, CR | 3 |
| Maher, EA | 4 |
| Choi, C | 4 |
| Keunen, O | 1 |
| Niclou, SP | 1 |
| Touat, M | 1 |
| Maher, E | 1 |
| De La Fuente, MI | 1 |
| Holdhoff, M | 1 |
| Cote, GM | 1 |
| Burris, H | 1 |
| Janku, F | 1 |
| Young, RJ | 1 |
| Huang, R | 1 |
| Jiang, L | 1 |
| Choe, S | 1 |
| Fan, B | 1 |
| Yen, K | 1 |
| Lu, M | 1 |
| Bowden, C | 1 |
| Ngo, B | 1 |
| Kim, E | 1 |
| Osorio-Vasquez, V | 1 |
| Doll, S | 1 |
| Bustraan, S | 1 |
| Liang, RJ | 1 |
| Luengo, A | 1 |
| Davidson, SM | 1 |
| Ali, A | 1 |
| Ferraro, GB | 1 |
| Fischer, GM | 1 |
| Eskandari, R | 1 |
| Kang, DS | 1 |
| Ni, J | 1 |
| Plasger, A | 1 |
| Rajasekhar, VK | 1 |
| Kastenhuber, ER | 1 |
| Bacha, S | 1 |
| Sriram, RK | 1 |
| Stein, BD | 1 |
| Bakhoum, SF | 1 |
| Snuderl, M | 2 |
| Cotzia, P | 1 |
| Healey, JH | 1 |
| Mainolfi, N | 1 |
| Suri, V | 1 |
| Friedman, A | 1 |
| Manfredi, M | 1 |
| Sabatini, DM | 2 |
| Jones, DR | 1 |
| Yu, M | 1 |
| Zhao, JJ | 1 |
| Jain, RK | 1 |
| Keshari, KR | 1 |
| Davies, MA | 1 |
| Vander Heiden, MG | 2 |
| Hernando, E | 1 |
| Mann, M | 1 |
| Cantley, LC | 1 |
| Pacold, ME | 2 |
| Chen, KY | 1 |
| Bush, K | 1 |
| Klein, RH | 1 |
| Cervantes, V | 1 |
| Lewis, N | 1 |
| Naqvi, A | 1 |
| Carcaboso, AM | 1 |
| Lechpammer, M | 1 |
| Knoepfler, PS | 1 |
| Molloy, AR | 1 |
| Najac, C | 1 |
| Viswanath, P | 1 |
| Lakhani, A | 1 |
| Subramani, E | 1 |
| Batsios, G | 1 |
| Radoul, M | 1 |
| Gillespie, AM | 1 |
| Pieper, RO | 1 |
| Ronen, SM | 1 |
| Fischer, I | 1 |
| Nickel, AC | 1 |
| Qin, N | 1 |
| Taban, K | 1 |
| Pauck, D | 1 |
| Steiger, HJ | 1 |
| Kamp, M | 1 |
| Muhammad, S | 1 |
| Hänggi, D | 1 |
| Fritsche, E | 1 |
| Remke, M | 1 |
| Kahlert, UD | 1 |
| Tanaka, K | 1 |
| Sasayama, T | 1 |
| Nagashima, H | 1 |
| Irino, Y | 1 |
| Takahashi, M | 1 |
| Izumi, Y | 1 |
| Uno, T | 1 |
| Satoh, N | 1 |
| Kitta, A | 1 |
| Kyotani, K | 1 |
| Fujita, Y | 1 |
| Hashiguchi, M | 1 |
| Nakai, T | 1 |
| Kohta, M | 1 |
| Uozumi, Y | 1 |
| Shinohara, M | 1 |
| Hosoda, K | 1 |
| Bamba, T | 1 |
| Kohmura, E | 1 |
| Leske, H | 1 |
| Rushing, E | 1 |
| Budka, H | 1 |
| Niehusmann, P | 1 |
| Pahnke, J | 1 |
| Panagopoulos, I | 1 |
| Voon, HPJ | 1 |
| Udugama, M | 1 |
| Lin, W | 1 |
| Hii, L | 1 |
| Law, RHP | 1 |
| Steer, DL | 1 |
| Das, PP | 1 |
| Mann, JR | 1 |
| Wong, LH | 1 |
| Carlin, D | 1 |
| Babourina-Brooks, B | 1 |
| Arvanitis, TN | 2 |
| Wilson, M | 2 |
| Peet, AC | 2 |
| Qin, H | 1 |
| Jiang, Y | 1 |
| Zhang, J | 1 |
| Deng, C | 1 |
| Zhong, Z | 1 |
| Maudsley, AA | 1 |
| Gupta, RK | 1 |
| Stoyanova, R | 1 |
| Parra, NA | 1 |
| Roy, B | 1 |
| Sheriff, S | 1 |
| Hussain, N | 1 |
| Behari, S | 1 |
| Pasupuleti, N | 1 |
| Grodzki, AC | 1 |
| Gorin, F | 1 |
| Kim, D | 1 |
| Fiske, BP | 1 |
| Birsoy, K | 1 |
| Freinkman, E | 1 |
| Kami, K | 1 |
| Possemato, RL | 1 |
| Chudnovsky, Y | 1 |
| Chen, WW | 1 |
| Cantor, JR | 1 |
| Shelton, LM | 1 |
| Gui, DY | 1 |
| Kwon, M | 1 |
| Ramkissoon, SH | 1 |
| Ligon, KL | 1 |
| Kang, SW | 1 |
| Thomas, AG | 1 |
| Sattler, R | 1 |
| Tendyke, K | 1 |
| Loiacono, KA | 1 |
| Hansen, H | 1 |
| Sahni, V | 1 |
| Hashizume, Y | 1 |
| Rojas, C | 1 |
| Slusher, BS | 1 |
| Ghasemi, K | 1 |
| Khanmohammadi, M | 1 |
| Saligheh Rad, H | 1 |
| Solomon, DA | 1 |
| Wood, MD | 1 |
| Tihan, T | 1 |
| Bollen, AW | 1 |
| Gupta, N | 1 |
| Phillips, JJ | 1 |
| Perry, A | 1 |
| Davies, NP | 1 |
| Natarajan, K | 1 |
| Sun, Y | 1 |
| MacPherson, L | 1 |
| Brundler, MA | 1 |
| Grundy, RG | 1 |
| Righi, V | 1 |
| Andronesi, OC | 1 |
| Mintzopoulos, D | 1 |
| Black, PM | 1 |
| Tzika, AA | 2 |
| Bobek-Billewicz, B | 1 |
| Hebda, A | 1 |
| Stasik-Pres, G | 1 |
| Majchrzak, K | 1 |
| Zmuda, E | 1 |
| Trojanowska, A | 1 |
| Wang, YY | 1 |
| Liu, SC | 1 |
| Yang, Z | 1 |
| Zhang, T | 1 |
| Dimitrov, IE | 1 |
| Pascual, JM | 2 |
| Bachoo, R | 1 |
| Custódio, AC | 1 |
| Almeida, LO | 1 |
| Pinto, GR | 1 |
| Santos, MJ | 1 |
| Almeida, JR | 1 |
| Clara, CA | 1 |
| Rey, JA | 1 |
| Casartelli, C | 1 |
| Nuthalapati, S | 1 |
| Guo, P | 1 |
| Zhou, Q | 1 |
| Reddy, MV | 1 |
| Reddy, EP | 1 |
| Gallo, JM | 1 |
| Shah, T | 1 |
| Jayasundar, R | 1 |
| Singh, VP | 1 |
| Sarkar, C | 1 |
| Marin-Valencia, I | 1 |
| Bachoo, RM | 1 |
| Mashimo, T | 1 |
| Raisanen, J | 1 |
| Jindal, A | 1 |
| Jeffrey, FM | 1 |
| Madden, C | 1 |
| Mathews, D | 1 |
| Londoño, A | 1 |
| Castillo, M | 1 |
| Armao, D | 1 |
| Kwock, L | 1 |
| Suzuki, K | 1 |
| Schroeder, PE | 1 |
| Jensen, PB | 1 |
| Sehested, M | 1 |
| Hofland, KF | 1 |
| Langer, SW | 1 |
| Hasinoff, BB | 1 |
| GAL, EM | 2 |
| Brennan, L | 1 |
| Hewage, C | 1 |
| Malthouse, JP | 1 |
| McBean, GJ | 1 |
| Chung, WJ | 1 |
| Lyons, SA | 1 |
| Nelson, GM | 1 |
| Hamza, H | 1 |
| Gladson, CL | 1 |
| Gillespie, GY | 1 |
| Sontheimer, H | 2 |
| Kohl, RL | 1 |
| Perez-Polo, JR | 1 |
| Quay, WB | 1 |
| Hagberg, G | 1 |
| Burlina, AP | 1 |
| Mader, I | 1 |
| Roser, W | 1 |
| Radue, EW | 1 |
| Seelig, J | 1 |
| Kinoshita, Y | 2 |
| Kajiwara, H | 2 |
| Yokota, A | 2 |
| Koga, Y | 2 |
| Vigneron, DB | 1 |
| Dunn, RS | 1 |
| Nelson, SJ | 1 |
| Ball, WS | 1 |
| Gutowski, NJ | 1 |
| Gómez-Ansón, B | 1 |
| Torpey, N | 1 |
| Revesz, T | 1 |
| Miller, D | 1 |
| Rudge, P | 1 |
| Ye, ZC | 1 |
| Rothstein, JD | 1 |
| Kanamori, M | 1 |
| Kumabe, T | 1 |
| Shimizu, H | 1 |
| Yoshimoto, T | 1 |
| Brüstle, O | 1 |
| Ohgaki, H | 1 |
| Schmitt, HP | 1 |
| Walter, GF | 1 |
| Ostertag, H | 1 |
| Kleihues, P | 1 |
| Johnström, P | 1 |
| Stone-Elander, S | 1 |
| Ericson, K | 1 |
| Mosskin, M | 1 |
| Bergström, M | 1 |
| Snodgrass, SR | 1 |
| Iversen, LL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase 1, Multicenter, Open-Label, Dose-Escalation and Expansion, Safety, Pharmacokinetic, Pharmacodynamic, and Clinical Activity Study of Orally Administered AG-120 in Subjects With Advanced Solid Tumors, Including Glioma, With an IDH1 Mutation[NCT02073994] | Phase 1 | 170 participants (Anticipated) | Interventional | 2014-03-01 | Active, not recruiting | ||
| Treatment Development of Triheptanoin for Glucose Transporter Type I Deficiency[NCT02021526] | Phase 1/Phase 2 | 0 participants (Actual) | Interventional | 2015-12-31 | Withdrawn (stopped due to NIH funding resulted in new clinical trial) | ||
| Role of Glutamate-mediate Excitotoxicity in Invasion and Progression Processes of Glioblastoma Multiforme[NCT05775458] | 50 participants (Anticipated) | Observational | 2020-06-01 | Recruiting | |||
| Phase I Trial Combining Sulfasalazine and Gamma Knife Radiosurgery for Recurrent Glioblastoma[NCT04205357] | Phase 1 | 24 participants (Actual) | Interventional | 2020-03-01 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for glycine and Brain Neoplasms
| Article | Year |
|---|---|
The prognostic significance of further genotyping H3G34 diffuse hemispheric gliomas.
Topics: Brain Neoplasms; Genotype; Glioma; Glycine; Humans; Prognosis | 2022 |
2 trials available for glycine and Brain Neoplasms
| Article | Year |
|---|---|
Volumetric measurements are preferred in the evaluation of mutant IDH inhibition in non-enhancing diffuse gliomas: Evidence from a phase I trial of ivosidenib.
Topics: Brain Neoplasms; Glioma; Glycine; Humans; Isocitrate Dehydrogenase; Magnetic Resonance Imaging; Pyri | 2022 |
Ivosidenib in Isocitrate Dehydrogenase 1
Topics: Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Dose-Response Relationship, Drug; Enzyme Inhibi | 2020 |
44 other studies available for glycine and Brain Neoplasms
| Article | Year |
|---|---|
Epigenetically defined therapeutic targeting in H3.3G34R/V high-grade gliomas.
Topics: Animals; Brain Neoplasms; Epigenesis, Genetic; Glioma; Glycine; Histones; Humans; Mice | 2021 |
Glycine by MR spectroscopy is an imaging biomarker of glioma aggressiveness.
Topics: Adult; Aged; Biomarkers; Brain Neoplasms; Contrast Media; Female; Gadolinium; Glioma; Glutarates; Gl | 2020 |
Is there a prominent role for MR spectroscopy in the clinical management of brain tumors?
Topics: Biomarkers; Brain Neoplasms; Glioma; Glycine; Humans; Magnetic Resonance Spectroscopy | 2020 |
Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition.
Topics: Animals; Antineoplastic Agents; Brain; Brain Neoplasms; Cell Line, Tumor; Datasets as Topic; Drug Re | 2020 |
Reciprocal H3.3 gene editing identifies K27M and G34R mechanisms in pediatric glioma including NOTCH signaling.
Topics: Animals; Apoptosis; Biomarkers, Tumor; Brain Neoplasms; Cell Proliferation; Child; Female; Gene Edit | 2020 |
MR-detectable metabolic biomarkers of response to mutant IDH inhibition in low-grade glioma.
Topics: Antineoplastic Agents; Biomarkers, Tumor; Brain Neoplasms; Carbon-13 Magnetic Resonance Spectroscopy | 2020 |
Different Calculation Strategies Are Congruent in Determining Chemotherapy Resistance of Brain Tumors In Vitro.
Topics: Antineoplastic Agents; Area Under Curve; Bortezomib; Brain Neoplasms; Cell Line, Tumor; Drug Resista | 2020 |
Glioma cells require one-carbon metabolism to survive glutamine starvation.
Topics: Aminohydrolases; Autophagy; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Ge | 2021 |
Measurement of glycine in healthy and tumorous brain by triple-refocusing MRS at 3 T in vivo.
Topics: Adult; Brain; Brain Neoplasms; Female; Glycine; Gray Matter; Humans; Inositol; Linear Models; Magnet | 2017 |
K27/G34 versus K28/G35 in histone H3-mutant gliomas: A note of caution.
Topics: Brain Neoplasms; DNA Mutational Analysis; Glioma; Glycine; Histones; Humans; Lysine; Mutation | 2018 |
Inhibition of a K9/K36 demethylase by an H3.3 point mutation found in paediatric glioblastoma.
Topics: Animals; Arginine; Biotinylation; Brain Neoplasms; Child; Chromatin; Disease Models, Animal; Embryon | 2018 |
Short-acquisition-time JPRESS and its application to paediatric brain tumours.
Topics: Adult; Biomarkers, Tumor; Brain; Brain Neoplasms; Child; Female; Glycine; Healthy Volunteers; Humans | 2019 |
Oncoprotein Inhibitor Rigosertib Loaded in ApoE-Targeted Smart Polymersomes Reveals High Safety and Potency against Human Glioblastoma in Mice.
Topics: Animals; Antineoplastic Agents; Apolipoproteins E; Blood-Brain Barrier; Brain Neoplasms; Cell Line, | 2019 |
Mapping of glycine distributions in gliomas.
Topics: Adolescent; Adult; Aged; Astrocytoma; Brain; Brain Mapping; Brain Neoplasms; Choline; Diffusion Magn | 2014 |
Mis-trafficking of endosomal urokinase proteins triggers drug-induced glioma nonapoptotic cell death.
Topics: Amiloride; Antineoplastic Agents; Apoptosis Inducing Factor; Brain Neoplasms; Cell Line, Tumor; Endo | 2015 |
SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance.
Topics: Acetone; Animals; Brain Neoplasms; Cell Hypoxia; Cell Line, Tumor; Cell Survival; Female; Glioblasto | 2015 |
High-Throughput Assay Development for Cystine-Glutamate Antiporter (xc-) Highlights Faster Cystine Uptake than Glutamate Release in Glioma Cells.
Topics: Amino Acid Transport System y+; Benzoates; Brain Neoplasms; Cell Line, Tumor; Cystine; Databases, Ch | 2015 |
Accurate grading of brain gliomas by soft independent modeling of class analogy based on non-negative matrix factorization of proton magnetic resonance spectra.
Topics: Algorithms; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Glioma; Glycine; Humans; Neoplasm Gra | 2016 |
Diffuse Midline Gliomas with Histone H3-K27M Mutation: A Series of 47 Cases Assessing the Spectrum of Morphologic Variation and Associated Genetic Alterations.
Topics: Adolescent; Adult; Aged; Brain Neoplasms; Child; Child, Preschool; ErbB Receptors; Female; Gene Expr | 2016 |
Non-invasive detection of glycine as a biomarker of malignancy in childhood brain tumours using in-vivo 1H MRS at 1.5 tesla confirmed by ex-vivo high-resolution magic-angle spinning NMR.
Topics: Animals; Biomarkers, Tumor; Brain Neoplasms; Child; Glycine; Humans; Magnetic Resonance Spectroscopy | 2010 |
High-resolution magic angle spinning magnetic resonance spectroscopy detects glycine as a biomarker in brain tumors.
Topics: Adolescent; Adult; Biomarkers, Tumor; Brain Neoplasms; Glioblastoma; Glycine; Humans; Inositol; Magn | 2010 |
Measurement of glycine in a brain and brain tumors by means of 1H MRS.
Topics: Adult; Brain Chemistry; Brain Neoplasms; Female; Glioma; Glycine; Humans; Magnetic Resonance Imaging | 2010 |
Impaired hippocampal synaptic plasticity in C6 glioma-bearing rats.
Topics: Animals; Body Weight; Brain Neoplasms; Cell Line, Tumor; Chromatography, High Pressure Liquid; Disea | 2011 |
Measurement of glycine in the human brain in vivo by 1H-MRS at 3 T: application in brain tumors.
Topics: Brain Chemistry; Brain Neoplasms; Glioblastoma; Glycine; Humans; Imaging, Three-Dimensional; Inosito | 2011 |
Analysis of the polymorphisms XRCC1Arg194Trp and XRCC1Arg399Gln in gliomas.
Topics: Arginine; Brain Neoplasms; DNA Primers; DNA-Binding Proteins; Glioma; Glycine; Humans; Polymerase Ch | 2011 |
Application of a liquid chromatography-tandem mass spectrometry (LC/MS/MS) method to the pharmacokinetics of ON01910 in brain tumor-bearing mice.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Calibration; Chromatography, Liquid; Glycine; Limit | 2011 |
In vivo MRS study of intraventricular tumors.
Topics: Adolescent; Adult; Brain Neoplasms; Cerebral Ventricle Neoplasms; Diagnosis, Differential; Female; G | 2011 |
Metabolism of [U-13 C]glucose in human brain tumors in vivo.
Topics: Acetyl Coenzyme A; Blood Glucose; Brain Neoplasms; Breast Neoplasms; Carbon Isotopes; Carcinoma, Non | 2012 |
Unusual MR spectroscopic imaging pattern of an astrocytoma: lack of elevated choline and high myo-inositol and glycine levels.
Topics: Adult; Astrocytoma; Brain Neoplasms; Choline; Glycine; Humans; Inositol; Magnetic Resonance Spectros | 2003 |
Metabolism of dexrazoxane (ICRF-187) used as a rescue agent in cancer patients treated with high-dose etoposide.
Topics: Aged; Antineoplastic Agents, Phytogenic; Brain Neoplasms; Carcinoma, Non-Small-Cell Lung; Chemothera | 2003 |
Transfer of radioactive glycine to the brain of normal and tumor-bearing mice and the effect of malononitrile thereon.
Topics: Animals; Brain; Brain Neoplasms; Glycine; Mice; Nitriles | 1956 |
Transfer of radioactive glycine to the brain of normal and tumor-bearing mice and the effect of malononitrile thereon.
Topics: Animals; Brain; Brain Neoplasms; Glycine; Mice; Nitriles | 1956 |
Transfer of radioactive glycine to the brain of normal and tumor-bearing mice and the effect of malononitrile thereon.
Topics: Animals; Brain; Brain Neoplasms; Glycine; Mice; Nitriles | 1956 |
Transfer of radioactive glycine to the brain of normal and tumor-bearing mice and the effect of malononitrile thereon.
Topics: Animals; Brain; Brain Neoplasms; Glycine; Mice; Nitriles | 1956 |
Gliotoxins disrupt alanine metabolism and glutathione production in C6 glioma cells: a 13C NMR spectroscopic study.
Topics: Alanine; Alanine Transaminase; Brain Neoplasms; Cell Line, Tumor; Dicarboxylic Acids; Enzyme Inhibit | 2004 |
Inhibition of cystine uptake disrupts the growth of primary brain tumors.
Topics: Amino Acid Transport Systems; Animals; Apoptosis; Benzoates; Brain Neoplasms; Caspases; Cell Divisio | 2005 |
Inhibition of cystine uptake disrupts the growth of primary brain tumors.
Topics: Amino Acid Transport Systems; Animals; Apoptosis; Benzoates; Brain Neoplasms; Caspases; Cell Divisio | 2005 |
Inhibition of cystine uptake disrupts the growth of primary brain tumors.
Topics: Amino Acid Transport Systems; Animals; Apoptosis; Benzoates; Brain Neoplasms; Caspases; Cell Divisio | 2005 |
Inhibition of cystine uptake disrupts the growth of primary brain tumors.
Topics: Amino Acid Transport Systems; Animals; Apoptosis; Benzoates; Brain Neoplasms; Caspases; Cell Divisio | 2005 |
Effect of methionine, glycine and serine on serine hydroxymethyltransferase activity in rat glioma and human neuroblastoma cells.
Topics: Animals; Brain Neoplasms; Cell Line; Enzyme Activation; Glioma; Glycine; Glycine Hydroxymethyltransf | 1980 |
In vivo proton MR spectroscopy of human gliomas: definition of metabolic coordinates for multi-dimensional classification.
Topics: Adult; Aspartic Acid; Astrocytoma; Brain Neoplasms; Choline; Cluster Analysis; Creatine; Discriminan | 1995 |
Proton magnetic resonance spectroscopy of astrocytic tumors: an in vitro study.
Topics: Antibodies, Monoclonal; Astrocytoma; Brain Neoplasms; Choline; Creatine; Diagnosis, Differential; Fe | 1993 |
Proton magnetic resonance spectroscopy of brain tumors: an in vitro study.
Topics: Adolescent; Adult; Aged; Alanine; Aspartic Acid; Biomarkers, Tumor; Brain; Brain Neoplasms; Child; C | 1994 |
Intracranial tumors in children: small single-voxel proton MR spectroscopy using short- and long-echo sequences.
Topics: Adolescent; Aspartic Acid; Brain Neoplasms; Child; Child, Preschool; Choline; Creatinine; Female; Gl | 1996 |
Oligodendroglial gliomatosis cerebri: (1)H-MRS suggests elevated glycine/inositol levels.
Topics: Adult; Aspartic Acid; Biopsy, Needle; Brain Neoplasms; Glycine; Humans; Inositol; Magnetic Resonance | 1999 |
Compromised glutamate transport in human glioma cells: reduction-mislocalization of sodium-dependent glutamate transporters and enhanced activity of cystine-glutamate exchange.
Topics: Amino Acid Substitution; Amino Acid Transport System X-AG; Animals; Astrocytes; ATP-Binding Cassette | 1999 |
(201)Tl-SPECT, (1)H-MRS, and MIB-1 labeling index of central neurocytomas: three case reports.
Topics: Adult; Antigens, Nuclear; Brain Neoplasms; Cell Division; Glycine; Humans; Ki-67 Antigen; Magnetic R | 2002 |
Primitive neuroectodermal tumors after prophylactic central nervous system irradiation in children. Association with an activated K-ras gene.
Topics: Aspartic Acid; Base Sequence; Brain Neoplasms; Child; Child, Preschool; Codon; Female; Gene Expressi | 1992 |
11C-labelled glycine: synthesis and preliminary report on its use in the investigation of intracranial tumours using positron emission tomography.
Topics: Astrocytoma; Brain Neoplasms; Carbon Radioisotopes; Edetic Acid; Gallium Radioisotopes; Glycine; Hum | 1987 |
Amino acid uptake into human brain tumors.
Topics: Absorption; Alanine; Amino Acids; Aminobutyrates; Aspartic Acid; Astrocytoma; Autoradiography; Brain | 1974 |