glycine has been researched along with Brain Ischemia in 117 studies
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| " To determine the role of non-ionotropic activity of NMDARs in clinical relevant conditions, we tested the effect of glycine, a co-agonist of NMDARs, in rat middle cerebral artery occlusion (MCAO), an animal model of cerebral ischemia-reperfusion injury after the animals were injected with the NMDAR channel blocker MK-801 and the glycine receptor antagonist strychnine." | 7.85 | A non-ionotropic activity of NMDA receptors contributes to glycine-induced neuroprotection in cerebral ischemia-reperfusion injury. ( Chen, J; Feng, H; Hu, R; Jin, P; Lei, R; Liao, H; Wan, Q; Wan, Y; Zhang, Y; Zhang, Z; Zhuang, Y, 2017) |
| " The aim of this work was to evaluate the effects of brain preconditioning induced by sarcosine, a GlyT-1 inhibitor, against global cerebral ischemia and its relation to NMDAR." | 7.80 | Sarcosine preconditioning induces ischemic tolerance against global cerebral ischemia. ( da Costa, FL; de Paiva, MJ; Gomez, MV; Gomez, RS; Pinto, MC; Resende, RR; Romano-Silva, MA; Rosa, DV; Simão, F, 2014) |
| "The release of preloaded [3H]glycine from hippocampal slices from 7-day-old and 3-month-old (adult) mice was studied in different cell-damaging conditions, including hypoxia, hypoglycemia, ischemia, oxidative stress and the presence of free radicals and metabolic poisons, using a superfusion system." | 7.71 | Characteristics of hippocampal glycine release in cell-damaging conditions in the adult and developing mouse. ( Oja, SS; Saransaari, P, 2001) |
| "We investigated the relationships among N-methyl-D-aspartate, glycine, L-type voltage-dependent calcium channels, and [3H]dopamine release in a canine model of global cerebral ischemia/reperfusion." | 7.69 | Increased activation of L-type voltage-dependent calcium channels is associated with glycine enhancement of N-methyl-D-aspartate-stimulated dopamine release in global cerebral ischemia/reperfusion. ( Blanck, TJ; Fiskum, G; Fox, LG; Hoehner, PJ; Hurt, KJ; Rosenthal, RE; Werling, LL, 1994) |
| " The current investigation was conducted to evaluate the effect of isoflurane and N2O-fentanyl anesthesia on ischemia-induced glutamate release in the rat and to compare it with that of mild hypothermia, an intervention known to reduce glutamate release significantly." | 7.69 | Isoflurane reduces ischemia-induced glutamate release in rats subjected to forebrain ischemia. ( Cole, DJ; Drummond, JC; Goskowicz, RL; Patel, PM, 1995) |
| "Sequential changes of [3H]glycine binding in the gerbil were investigated in selectively vulnerable areas 1 h to 7 days after 10 min of cerebral ischemia." | 7.69 | Post-ischemic changes of [3H]glycine binding in the gerbil brain after cerebral ischemia. ( Araki, T; Fujiwara, T; Itoyama, Y; Kato, H; Kogure, K, 1995) |
| "Increased glutamic acid, aspartic acid, and gamma-aminobutyric acid and decreased glycine in plasma are associated with adverse outcomes after ischemic stroke, suggesting that plasma amino acid neurotransmitters may be potential intervention targets for improving prognosis of ischemic stroke." | 5.69 | Plasma Amino Acid Neurotransmitters and Ischemic Stroke Prognosis: A Multicenter Prospective Study. ( Chen, J; Guo, D; He, J; Jia, Y; Peng, H; Shi, M; Sun, L; Wang, A; Wang, Y; Xu, Q; Xu, T; Yang, P; Zhang, Y; Zhong, C; Zhu, Z, 2023) |
| "Treatment with glycine results in reduced infarct volume of the brain, neurologic function scores, and neuronal and microglial death in ischemic stroke injury." | 5.51 | Glycine Exhibits Neuroprotective Effects in Ischemic Stroke in Rats through the Inhibition of M1 Microglial Polarization via the NF-κB p65/Hif-1α Signaling Pathway. ( Bu, LH; Chen, SF; Liao, XY; Liu, R; Lu, LJ; Lu, PX; Pan, MX; Qin, XP; Tang, JC; Wan, Q; Zhang, Y; Zou, YY, 2019) |
| "Glycine is a cytoprotector to protect cells against ischemic damage by counteracting neuronal depolarization." | 5.38 | Glycine attenuates cerebral ischemia/reperfusion injury by inhibiting neuronal apoptosis in mice. ( Bai, H; Ben, J; Chen, Q; Li, K; Li, X; Lu, Y; Ma, B; Yang, Q; Zhang, J; Zhu, X, 2012) |
| "Nitric oxide release during cerebral ischemia is the result of both neuronal and endothelial subclasses of nitric oxide synthase (NOS)." | 5.30 | Modulation of ischemic excitatory neurotransmitter and gamma-aminobutyric acid release during global temporary cerebral ischemia by selective neuronal nitric oxide synthase inhibition. ( Kahn, RA; Panah, M; Weinberger, J, 1997) |
| "We analyzed data from the Glycine Antagonist in Neuroprotection (GAIN) Americas trial, in which 1604 non-obtunded patients with acute stroke were treated within 6 hours of symptom onset irrespective of hemorrhagic (N = 237) versus ischemic (N = 1367) subtype." | 5.14 | Comparison of outcomes after intracerebral hemorrhage and ischemic stroke. ( Chiu, D; Elkind, MSV; Gerber, LM; Peterson, L; Rosand, J; Silverstein, MD, 2010) |
| "We studied all patients of the Glycine Antagonist (gavestinel) In Neuroprotection (GAIN) International Trial with ischemic stroke alive at day 7, excluding patients with hemorrhagic events and deaths from nonstroke-related causes." | 5.11 | Poststroke neurological improvement within 7 days is associated with subsequent deterioration. ( Aslanyan, S; Johnston, SC; Lees, KR; Weir, CJ, 2004) |
| "FG-4592 pretreated BMSCs improve neurological function recovery after stroke and are likely to be a promising strategy for stroke management." | 4.12 | Transplantation of Roxadustat-preconditioned bone marrow stromal cells improves neurological function recovery through enhancing grafted cell survival in ischemic stroke rats. ( Bingwa, LA; Chen, J; Jin, K; Lin, X; Lin, Z; Wang, H; Yang, S; Yao, C; Zhuge, Q, 2022) |
| " To determine the role of non-ionotropic activity of NMDARs in clinical relevant conditions, we tested the effect of glycine, a co-agonist of NMDARs, in rat middle cerebral artery occlusion (MCAO), an animal model of cerebral ischemia-reperfusion injury after the animals were injected with the NMDAR channel blocker MK-801 and the glycine receptor antagonist strychnine." | 3.85 | A non-ionotropic activity of NMDA receptors contributes to glycine-induced neuroprotection in cerebral ischemia-reperfusion injury. ( Chen, J; Feng, H; Hu, R; Jin, P; Lei, R; Liao, H; Wan, Q; Wan, Y; Zhang, Y; Zhang, Z; Zhuang, Y, 2017) |
| "Neuroprotective properties of the new derivative of glutamic and apovincaminic acids, ethyl -(3-alpha,16-alpha)-eburnamenin-14-carbopxylate of 2-aminopentadionic acid (LHT 1-02) were studied on a model of acute brain ischemia in cats." | 3.80 | [Effect of a new derivative of glutamic and apovincaminic acids on brain metabolism in post-ischemic period]. ( Makarova, LM; Mirzoian, RS; Pogorelyĭ, VE; Prikhod'ko, MA; Skachilova, SIa, 2014) |
| " The aim of this work was to evaluate the effects of brain preconditioning induced by sarcosine, a GlyT-1 inhibitor, against global cerebral ischemia and its relation to NMDAR." | 3.80 | Sarcosine preconditioning induces ischemic tolerance against global cerebral ischemia. ( da Costa, FL; de Paiva, MJ; Gomez, MV; Gomez, RS; Pinto, MC; Resende, RR; Romano-Silva, MA; Rosa, DV; Simão, F, 2014) |
| " Although a number of studies have investigated that ginkgolide B, a purified terpene lactone component extracted from Ginkgo biloba leaves, is available "platelet activating factor (PAF) receptors antagonist", "antioxidant" with a variety of actions, very little has been performed to explore the effect of ginkgolide B on extracellular amino acids in experimental animal of focal cerebral ischemia/reperfusion." | 3.77 | Effect of ginkgolide B on striatal extracellular amino acids in middle cerebral artery occluded rats. ( Feng, W; Li, J; Li, SX; Wang, H; Yang, ZZ, 2011) |
| "The aims of the present work were to perform a comparative study of the effects of delta sleep-inducing peptide and Deltaran on neurons in emotiogenic brain structures and to address the question of whether it is possible to prevent or decrease the negative influences of stress loads on the severity of subsequent cerebral ischemia in rats, using glycine with delta sleep-inducing peptide combined in the neuroprotective formulation Deltaran." | 3.74 | Delta sleep-inducing peptide and Deltaran: potential approaches to antistress protection. ( Gannushkina, IV; Konorova, IL; Koplik, EV; Mikhaleva, II; Sudakov, KV; Terekhina, OL; Umryukhin, PE, 2008) |
| " Another goal was to analyze the possibility to prevent negative effects of emotional stress on brain ischemia using, along with deltaran, glycine and a delta-sleep inducing peptide." | 3.74 | [Delta-sleep inducing peptide and the drug deltaran: possible approaches to antistress protection]. ( Gannushkina, IV; Konorova, IL; Koplik, EV; Mikhaleva, II; Sudakov, KV; Terekhina, OL; Umriukhin, PE, 2007) |
| "The release of preloaded [3H]glycine from hippocampal slices from 7-day-old and 3-month-old (adult) mice was studied in different cell-damaging conditions, including hypoxia, hypoglycemia, ischemia, oxidative stress and the presence of free radicals and metabolic poisons, using a superfusion system." | 3.71 | Characteristics of hippocampal glycine release in cell-damaging conditions in the adult and developing mouse. ( Oja, SS; Saransaari, P, 2001) |
| " We hypothesized that CSF glutamate, aspartate, and glycine would be increased after TBI in children and that these increases would be associated with age, child abuse, poor outcome, and cerebral ischemia." | 3.71 | Excitatory amino acid concentrations in ventricular cerebrospinal fluid after severe traumatic brain injury in infants and children: the role of child abuse. ( Adelson, PD; Bell, MJ; Clark, RS; Graham, SH; Kochanek, PM; Marion, DW; Rose, ME; Ruppel, RA; Wisniewski, SR, 2001) |
| " To elucidate the role of group I mGluR, we tested the effects of (S)-alpha-methyl-4-carboxy-phenylglycine (MCPG, mGluR 1 and 5 antagonist), 1-aminoindan-1,5-dicarboxylic acid (AIDA, mGluR 1a specific antagonist) and 2-methyl-6-(phenylethynyl) pyridine (MPEP, mGluR 5 antagonist) on ArAc release and neuronal survival after transient forebrain ischemia in gerbils." | 3.70 | Neuroprotection by group I metabotropic glutamate receptor antagonists in forebrain ischemia of gerbil. ( Dempsey, RJ; Hatcher, JF; Rao, AM, 2000) |
| "To investigate global cerebral ischemia-induced alterations in the levels of glutamate, aspartate, gamma-aminobutyric acid (GABA), glutamine, glycine, and taurine from hippocampus, striatum, and cerebral cortex in gerbils." | 3.70 | Alterations of amino acid levels from striatum, hippocampus, and cerebral cortex induced by global cerebral ischemia in gerbil. ( Hu, G; Rao, MR; Tang, XC; Wang, H, 2000) |
| "Sequential changes of [3H]glycine binding in the gerbil were investigated in selectively vulnerable areas 1 h to 7 days after 10 min of cerebral ischemia." | 3.69 | Post-ischemic changes of [3H]glycine binding in the gerbil brain after cerebral ischemia. ( Araki, T; Fujiwara, T; Itoyama, Y; Kato, H; Kogure, K, 1995) |
| "The involvement of phospholipases in ischemia-evoked release of aspartate, glutamate, glycine, and GABA from the cerebral cortex was studied in a four vessel occlusion rat model of cerebral ischemia/reperfusion." | 3.69 | A possible role for phospholipases in the release of neurotransmitter amino acids from ischemic rat cerebral cortex. ( O'Regan, MH; Perkins, LM; Phillis, JW; Smith-Barbour, M, 1995) |
| "We investigated the relationships among N-methyl-D-aspartate, glycine, L-type voltage-dependent calcium channels, and [3H]dopamine release in a canine model of global cerebral ischemia/reperfusion." | 3.69 | Increased activation of L-type voltage-dependent calcium channels is associated with glycine enhancement of N-methyl-D-aspartate-stimulated dopamine release in global cerebral ischemia/reperfusion. ( Blanck, TJ; Fiskum, G; Fox, LG; Hoehner, PJ; Hurt, KJ; Rosenthal, RE; Werling, LL, 1994) |
| "Using high-performance liquid chromatography, we determined the glutamate, aspartate, taurine, and glycine concentrations in the plasma and cerebrospinal fluid (CSF) of 128 patients with ischemic cerebral infarction confirmed by CT and 43 control subjects." | 3.69 | Neuroexcitatory amino acids and their relation to infarct size and neurological deficit in ischemic stroke. ( Castillo, J; Dávalos, A; Naveiro, J; Noya, M, 1996) |
| "Several lines of inquiry have indicated that glycine plays an important role in both glutamatergic neurotransmission and pathophysiology of cerebral ischemia." | 3.69 | Neuroprotective effect of NMDA receptor glycine recognition site antagonism persists when brain temperature is controlled. ( Bart, RD; Brinkhous, A; Pearlstein, R; Takaoka, S; Warner, DS, 1997) |
| " The current investigation was conducted to evaluate the effect of isoflurane and N2O-fentanyl anesthesia on ischemia-induced glutamate release in the rat and to compare it with that of mild hypothermia, an intervention known to reduce glutamate release significantly." | 3.69 | Isoflurane reduces ischemia-induced glutamate release in rats subjected to forebrain ischemia. ( Cole, DJ; Drummond, JC; Goskowicz, RL; Patel, PM, 1995) |
| "We investigated the ability of N6-cyclohexyladenosine (CHA), a potent and selective agonist of the adenosine A1 receptor, to attenuate elevations of levels of extracellular hippocampal glutamate and glycine that result from episodes of transient global cerebral ischemia (TGCI)." | 3.68 | The effect of cyclohexyladenosine on the periischemic increases of hippocampal glutamate and glycine in the rabbit. ( Cantor, SL; Miller, LP; Yaksh, TL; Zornow, MH, 1992) |
| "Neonatal seizures, as distinguished from nonconvulsive abnormal movements, are a significant problem in neonatal intensive care units." | 2.37 | Neonatal seizures. ( Bergman, I; Crumrine, P; Painter, MJ, 1986) |
| "Treatment with glycine results in reduced infarct volume of the brain, neurologic function scores, and neuronal and microglial death in ischemic stroke injury." | 1.51 | Glycine Exhibits Neuroprotective Effects in Ischemic Stroke in Rats through the Inhibition of M1 Microglial Polarization via the NF-κB p65/Hif-1α Signaling Pathway. ( Bu, LH; Chen, SF; Liao, XY; Liu, R; Lu, LJ; Lu, PX; Pan, MX; Qin, XP; Tang, JC; Wan, Q; Zhang, Y; Zou, YY, 2019) |
| "Stroke is a multi-factorial disease influenced by both genetic and environmental factors." | 1.43 | Association between Endothelial nitric oxide synthase G894T gene polymorphism and risk of ischemic stroke in North Indian population: a case-control study. ( Chakravarty, K; Kathuria, P; Kumar, A; Kumar, P; Misra, S; Pandit, AK; Prasad, K; Sagar, R; Yadav, AK, 2016) |
| "Glycine is a cytoprotector to protect cells against ischemic damage by counteracting neuronal depolarization." | 1.38 | Glycine attenuates cerebral ischemia/reperfusion injury by inhibiting neuronal apoptosis in mice. ( Bai, H; Ben, J; Chen, Q; Li, K; Li, X; Lu, Y; Ma, B; Yang, Q; Zhang, J; Zhu, X, 2012) |
| "The MELAS has been related to mutation A3243G in most cases, but some other mitochondrial DNA mutations were described in the background of this syndrome as well." | 1.37 | A8344G mutation of the mitochondrial DNA with typical mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes syndrome. ( Gál, A; Lukács, T; Molnár, MJ; Reményi, V; Semjén, J; Valikovics, A; Vastagh, I, 2011) |
| "In conclusion, focal cerebral ischemia and reperfusion impaired vasoconstrictor responses in remote brain arteries of rats by a mechanism involving free radicals." | 1.36 | Decreased vasoconstrictor responses in remote cerebral arteries after focal brain ischemia and reperfusion in the rat, in vitro. ( Albert, M; Benedek, A; Hársing, LG; Kovács, A; Móricz, K; Szénási, G, 2010) |
| "Glycine (100 microM) was inactive in this assay indicating an absence of functional glycine-A receptors in this preparation." | 1.35 | Role of glycine receptors and glycine release for the neuroprotective activity of bilobalide. ( Hartmann, J; Hildmann, O; Hillert, M; Kiewert, C; Klein, J; Kumar, V, 2008) |
| " Agonists of the glycine recognition site of NMDA receptors (D-serine and D-alanine) did not have any toxic effect in hippocampal cultures, whereas competitive blockade of the glycine site by 7-chlorokynurenic acid was neuroprotective." | 1.33 | Glycine-induced neurotoxicity in organotypic hippocampal slice cultures. ( Barth, A; Barth, L; Newell, DW; Nguyen, LB, 2005) |
| "During cerebral ischemia, the opening of neuronal ATP-sensitive potassium channels (K(ATP) channels) affords intrinsic protection by regulating membrane potential." | 1.32 | Targeting ischemic stroke with a novel opener of ATP-sensitive potassium channels in the brain. ( Feng, HS; Hu, G; Tang, XC; Wang, H; Zhang, YL, 2004) |
| "We introduced intracerebral hemorrhage in each of eight anesthetized New Zealand rabbits by injecting 0." | 1.32 | Extracellular glutamate and other amino acids in experimental intracerebral hemorrhage: an in vivo microdialysis study. ( Ali, Z; Baker, G; Guterman, LR; Hopkins, LN; Qureshi, AI; Shuaib, A; Suri, MF; Todd, K, 2003) |
| "Nitric oxide release during cerebral ischemia is the result of both neuronal and endothelial subclasses of nitric oxide synthase (NOS)." | 1.30 | Modulation of ischemic excitatory neurotransmitter and gamma-aminobutyric acid release during global temporary cerebral ischemia by selective neuronal nitric oxide synthase inhibition. ( Kahn, RA; Panah, M; Weinberger, J, 1997) |
| "Acute subdural hematoma (SDH) complicates about 20% of severely head-injured patients, and death and severe disability frequently result, yet over half of these patients may have been conscious, at some time after injury, implying secondary mechanisms of brain damage." | 1.29 | The effect of the glycine site-specific N-methyl-D-aspartate antagonist ACEA1021 on ischemic brain damage caused by acute subdural hematoma in the rat. ( Bullock, R; Tsuchida, E, 1995) |
| "A cardiac arrest was induced with intravenous KCl, and the times until electroencephalograph isoelectricity and terminal depolarization were recorded." | 1.29 | Effects of hypothermia on the rate of excitatory amino acid release after ischemic depolarization. ( Nakashima, K; Todd, MM, 1996) |
| "Glycine levels were significantly depressed, both pre- and post-ischemia, in cortical superfusates from hypothermic animals in comparison with normothermic rats." | 1.28 | The effects of hypothermia on amino acid neurotransmitter release from the cerebral cortex. ( Phillis, JW; Simpson, RE; Walter, GA, 1991) |
| "The effect of anoxia and ischemia on the release of amino acid transmitters from cerebellar slices induced by veratridine or high [K+] was studied." | 1.27 | Effects of anoxia on the stimulated release of amino acid neurotransmitters in the cerebellum in vitro. ( Balázs, R; Bosley, TM; Gordon, RD; Woodhams, PL, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (4.27) | 18.7374 |
| 1990's | 42 (35.90) | 18.2507 |
| 2000's | 39 (33.33) | 29.6817 |
| 2010's | 27 (23.08) | 24.3611 |
| 2020's | 4 (3.42) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, J | 3 |
| Lin, X | 1 |
| Yao, C | 1 |
| Bingwa, LA | 1 |
| Wang, H | 4 |
| Lin, Z | 1 |
| Jin, K | 1 |
| Zhuge, Q | 1 |
| Yang, S | 1 |
| Zhu, Z | 1 |
| Yang, P | 2 |
| Jia, Y | 1 |
| Wang, Y | 3 |
| Shi, M | 1 |
| Zhong, C | 1 |
| Peng, H | 1 |
| Sun, L | 1 |
| Guo, D | 1 |
| Xu, Q | 1 |
| Wang, A | 1 |
| Xu, T | 1 |
| He, J | 1 |
| Zhang, Y | 4 |
| Horinokita, I | 2 |
| Hayashi, H | 2 |
| Oteki, R | 1 |
| Mizumura, R | 1 |
| Yamaguchi, T | 1 |
| Usui, A | 1 |
| Yuan, B | 1 |
| Takagi, N | 2 |
| Gerace, E | 1 |
| Scartabelli, T | 1 |
| Pellegrini-Giampietro, DE | 2 |
| Landucci, E | 1 |
| Yoshizawa, R | 1 |
| Ichiyanagi, M | 1 |
| Imamura, Y | 1 |
| Iwatani, Y | 1 |
| Hu, R | 1 |
| Liao, H | 1 |
| Lei, R | 1 |
| Zhang, Z | 1 |
| Zhuang, Y | 1 |
| Wan, Y | 1 |
| Jin, P | 1 |
| Feng, H | 1 |
| Wan, Q | 2 |
| Liu, R | 1 |
| Liao, XY | 1 |
| Pan, MX | 1 |
| Tang, JC | 1 |
| Chen, SF | 1 |
| Lu, PX | 1 |
| Lu, LJ | 1 |
| Zou, YY | 1 |
| Qin, XP | 1 |
| Bu, LH | 1 |
| Fan, D | 1 |
| Krishnamurthi, R | 1 |
| Harris, P | 1 |
| Barber, PA | 1 |
| Guan, J | 2 |
| Krylov, VN | 1 |
| Deriugina, AV | 1 |
| Antipenko, EA | 1 |
| Zakharova, OA | 1 |
| Li, H | 1 |
| Zhang, N | 2 |
| Sun, G | 1 |
| Ding, S | 1 |
| Gluckman, P | 1 |
| Krissansen, G | 1 |
| Sun, X | 1 |
| Zhou, Y | 1 |
| Wen, J | 1 |
| Phillips, G | 1 |
| Shorten, PR | 1 |
| McMahon, CD | 1 |
| Wake, GC | 1 |
| Chan, WH | 1 |
| Thomas, MF | 1 |
| Ren, A | 1 |
| Moon, S | 1 |
| Liu, DX | 1 |
| Makarova, LM | 1 |
| Prikhod'ko, MA | 1 |
| Pogorelyĭ, VE | 1 |
| Skachilova, SIa | 1 |
| Mirzoian, RS | 1 |
| Pinto, MC | 1 |
| Simão, F | 1 |
| da Costa, FL | 1 |
| Rosa, DV | 1 |
| de Paiva, MJ | 1 |
| Resende, RR | 1 |
| Romano-Silva, MA | 1 |
| Gomez, MV | 1 |
| Gomez, RS | 1 |
| Chen, RL | 1 |
| Ogunshola, OO | 1 |
| Yeoh, KK | 1 |
| Jani, A | 1 |
| Papadakis, M | 1 |
| Nagel, S | 1 |
| Schofield, CJ | 1 |
| Buchan, AM | 1 |
| Soria, FN | 1 |
| Pérez-Samartín, A | 1 |
| Martin, A | 1 |
| Gona, KB | 1 |
| Llop, J | 1 |
| Szczupak, B | 1 |
| Chara, JC | 1 |
| Matute, C | 1 |
| Domercq, M | 1 |
| Wang, YG | 1 |
| Ma, TF | 1 |
| Li, M | 1 |
| Gu, SL | 1 |
| Chen, Z | 2 |
| Hu, B | 1 |
| Wang, F | 1 |
| Du, L | 1 |
| Huang, B | 1 |
| Li, L | 1 |
| Qi, J | 1 |
| Wang, X | 1 |
| Nik Ramli, NN | 1 |
| Omar, N | 1 |
| Husin, A | 1 |
| Ismail, Z | 1 |
| Siran, R | 1 |
| Kumar, A | 1 |
| Misra, S | 1 |
| Kumar, P | 1 |
| Sagar, R | 1 |
| Prasad, K | 1 |
| Pandit, AK | 1 |
| Chakravarty, K | 1 |
| Kathuria, P | 1 |
| Yadav, AK | 1 |
| Koplik, EV | 4 |
| Umryukhin, PE | 1 |
| Konorova, IL | 4 |
| Terekhina, OL | 2 |
| Mikhaleva, II | 2 |
| Gannushkina, IV | 4 |
| Sudakov, KV | 2 |
| Matayoshi, H | 1 |
| Hirata, T | 1 |
| Yamashita, S | 1 |
| Ishida, K | 1 |
| Mizukami, Y | 1 |
| Gondo, T | 1 |
| Matsumoto, M | 1 |
| Sakabe, T | 1 |
| Oja, SS | 3 |
| Saransaari, P | 3 |
| Macdonald, RL | 1 |
| Samuelsson, C | 1 |
| Howells, T | 1 |
| Kumlien, E | 1 |
| Enblad, P | 1 |
| Hillered, L | 1 |
| Ronne-Engström, E | 1 |
| Chiu, D | 1 |
| Peterson, L | 1 |
| Elkind, MSV | 1 |
| Rosand, J | 1 |
| Gerber, LM | 1 |
| Silverstein, MD | 1 |
| Luccini, E | 1 |
| Romei, C | 1 |
| Di Prisco, S | 1 |
| Raiteri, M | 1 |
| Raiteri, L | 1 |
| Kovács, A | 1 |
| Móricz, K | 1 |
| Albert, M | 1 |
| Benedek, A | 1 |
| Hársing, LG | 1 |
| Szénási, G | 1 |
| Tanabe, M | 1 |
| Nitta, A | 1 |
| Ono, H | 1 |
| Feng, RF | 1 |
| Li, WB | 1 |
| Liu, HQ | 1 |
| Li, QJ | 1 |
| Chen, XL | 1 |
| Zhou, AM | 1 |
| Zhao, HG | 1 |
| Ai, J | 1 |
| Yang, ZZ | 1 |
| Li, J | 1 |
| Li, SX | 1 |
| Feng, W | 1 |
| Vlasov, TD | 1 |
| Chefu, SG | 1 |
| Baĭsa, AE | 1 |
| Leko, MV | 1 |
| Burov, SV | 1 |
| Veselkina, OS | 1 |
| Reismann, P | 1 |
| Markoula, S | 1 |
| Milionis, H | 1 |
| Lazaros, L | 1 |
| Spengos, K | 1 |
| Vassilopoulou, S | 1 |
| Chatzistefanidis, D | 1 |
| Kargiotis, O | 1 |
| Georgiou, I | 1 |
| Kyritsis, AP | 1 |
| Vastagh, I | 1 |
| Gál, A | 1 |
| Reményi, V | 1 |
| Semjén, J | 1 |
| Lukács, T | 1 |
| Valikovics, A | 1 |
| Molnár, MJ | 1 |
| Yao, W | 1 |
| Ji, F | 1 |
| Ren, SQ | 1 |
| Zhang, XY | 1 |
| Liu, SY | 1 |
| Lu, W | 1 |
| Lu, Y | 1 |
| Zhang, J | 1 |
| Ma, B | 1 |
| Li, K | 1 |
| Li, X | 1 |
| Bai, H | 1 |
| Yang, Q | 1 |
| Zhu, X | 1 |
| Ben, J | 1 |
| Chen, Q | 2 |
| Selin, AA | 1 |
| Lobysheva, NV | 1 |
| Vorontsova, ON | 1 |
| Tonshin, AA | 1 |
| Yaguzhinsky, LS | 1 |
| Nartsissov, YR | 1 |
| Meli, E | 1 |
| Picca, R | 1 |
| Attucci, S | 1 |
| Cozzi, A | 1 |
| Peruginelli, F | 1 |
| Moroni, F | 1 |
| Qureshi, AI | 1 |
| Ali, Z | 1 |
| Suri, MF | 1 |
| Shuaib, A | 2 |
| Baker, G | 1 |
| Todd, K | 1 |
| Guterman, LR | 1 |
| Hopkins, LN | 1 |
| Pongrácz, E | 1 |
| Tordai, A | 1 |
| Csornai, M | 1 |
| Béla, Z | 1 |
| Nagy, Z | 1 |
| Chandrasekaran, K | 1 |
| Mehrabian, Z | 1 |
| Spinnewyn, B | 1 |
| Chinopoulos, C | 1 |
| Drieu, K | 1 |
| Fiskum, G | 2 |
| Aslanyan, S | 1 |
| Weir, CJ | 1 |
| Johnston, SC | 1 |
| Lees, KR | 2 |
| Zhang, YL | 1 |
| Tang, XC | 2 |
| Feng, HS | 1 |
| Hu, G | 2 |
| Barth, A | 2 |
| Nguyen, LB | 1 |
| Barth, L | 1 |
| Newell, DW | 2 |
| Antelava, AL | 2 |
| Xiao, ZY | 1 |
| Sun, CK | 1 |
| Xiao, XW | 1 |
| Lin, YZ | 1 |
| Li, S | 1 |
| Ma, H | 1 |
| Song, GR | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase II Study of the Effects of Tiopronin on 3-Aminopropanal Level & Neurologic Outcome After Aneurysmal Subarachnoid Hemorrhage[NCT01095731] | Phase 2 | 60 participants (Actual) | Interventional | 2010-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for glycine and Brain Ischemia
| Article | Year |
|---|---|
Clinical experience with excitatory amino acid antagonist drugs.
Topics: Brain Ischemia; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Humans; Magnesium; Neurop | 1995 |
Role of excitotoxins in developmental neuropathology.
Topics: Amino Acid Metabolism, Inborn Errors; Aspartic Acid; Brain Diseases; Brain Ischemia; Cloning, Molecu | 1993 |
Neonatal seizures.
Topics: Adrenoleukodystrophy; Amino Acid Metabolism, Inborn Errors; Ammonia; Anesthetics, Local; Anticonvuls | 1986 |
5 trials available for glycine and Brain Ischemia
| Article | Year |
|---|---|
Plasma Amino Acid Neurotransmitters and Ischemic Stroke Prognosis: A Multicenter Prospective Study.
Topics: Aspartic Acid; Biomarkers; Brain Ischemia; Cohort Studies; gamma-Aminobutyric Acid; Glutamic Acid; G | 2023 |
Comparison of outcomes after intracerebral hemorrhage and ischemic stroke.
Topics: Acute Disease; Aged; Brain Ischemia; Cerebral Hemorrhage; Cohort Studies; Disability Evaluation; Dou | 2010 |
Poststroke neurological improvement within 7 days is associated with subsequent deterioration.
Topics: Aged; Aged, 80 and over; Brain Damage, Chronic; Brain Edema; Brain Ischemia; Cohort Studies; Double- | 2004 |
[A comprehensive clinico-neurophysiological study of the efficacy of the pharmaceutical preparation glycine in acute ischemic stroke].
Topics: Acute Disease; Aged; Brain; Brain Ischemia; Dose-Response Relationship, Drug; Double-Blind Method; F | 1995 |
[Neuroprotective effects of glycine in the acute period of ischemic stroke].
Topics: Acute Disease; Administration, Sublingual; Adult; Aged; Autoantibodies; Brain Ischemia; Double-Blind | 1999 |
109 other studies available for glycine and Brain Ischemia
| Article | Year |
|---|---|
Transplantation of Roxadustat-preconditioned bone marrow stromal cells improves neurological function recovery through enhancing grafted cell survival in ischemic stroke rats.
Topics: Animals; Bone Marrow Cells; Bone Marrow Transplantation; Brain Ischemia; Cell Survival; Glycine; Inf | 2022 |
Involvement of Progranulin and Granulin Expression in Inflammatory Responses after Cerebral Ischemia.
Topics: Animals; Brain Ischemia; Cells, Cultured; Cytokines; Disease Models, Animal; Glycine; Granulins; Leu | 2019 |
Tolerance Induced by (S)-3,5-Dihydroxyphenylglycine Postconditioning is Mediated by the PI3K/Akt/GSK3β Signalling Pathway in an In Vitro Model of Cerebral Ischemia.
Topics: Brain Ischemia; Glycine; Glycogen Synthase Kinase 3 beta; Humans; Methoxyhydroxyphenylglycol; Neurop | 2020 |
Possible involvement of progranulin in the protective effect of elastase inhibitor on cerebral ischemic injuries of neuronal and glial cells.
Topics: Animals; Anti-Inflammatory Agents; Brain Ischemia; Cell Hypoxia; Cells, Cultured; Cytokines; Glycine | 2021 |
A non-ionotropic activity of NMDA receptors contributes to glycine-induced neuroprotection in cerebral ischemia-reperfusion injury.
Topics: Animals; Brain Ischemia; Disease Models, Animal; Glutamic Acid; Glycine; Male; Neuroprotection; Prot | 2017 |
Glycine Exhibits Neuroprotective Effects in Ischemic Stroke in Rats through the Inhibition of M1 Microglial Polarization via the NF-κB p65/Hif-1α Signaling Pathway.
Topics: Animals; Brain; Brain Ischemia; Female; Glycine; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Mi | 2019 |
Plasma cyclic glycine proline/IGF-1 ratio predicts clinical outcome and recovery in stroke patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Brain Ischemia; Female; Glycine; Humans; Insulin-Like Gr | 2019 |
[The diagnostics of adaptive reactions of blood on application the stress-modulating therapy in patients with brain chronic ischemia].
Topics: Adult; Brain Ischemia; Chronic Disease; Delta Sleep-Inducing Peptide; Drug Combinations; Erythrocyte | 2012 |
Inhibition of the group I mGluRs reduces acute brain damage and improves long-term histological outcomes after photothrombosis-induced ischaemia.
Topics: Animals; Antimetabolites, Antineoplastic; Astrocytes; Benzoates; Blotting, Western; Brain; Brain Isc | 2013 |
Cyclic glycine-proline regulates IGF-1 homeostasis by altering the binding of IGFBP-3 to IGF-1.
Topics: Animals; Antineoplastic Agents; Brain Ischemia; Cell Line; Corpus Striatum; Endothelial Cells; Gene | 2014 |
[Effect of a new derivative of glutamic and apovincaminic acids on brain metabolism in post-ischemic period].
Topics: Acidosis, Lactic; Animals; Blood Glucose; Brain; Brain Ischemia; Cats; Glutamic Acid; Glycine; Lacti | 2014 |
Sarcosine preconditioning induces ischemic tolerance against global cerebral ischemia.
Topics: Animals; Brain Ischemia; Cell Death; Disease Models, Animal; Glycine; Glycine Plasma Membrane Transp | 2014 |
HIF prolyl hydroxylase inhibition prior to transient focal cerebral ischaemia is neuroprotective in mice.
Topics: Animals; Brain Ischemia; Cells, Cultured; Glycine; Hypoxia-Inducible Factor 1, alpha Subunit; Hypoxi | 2014 |
Extrasynaptic glutamate release through cystine/glutamate antiporter contributes to ischemic damage.
Topics: Amino Acid Transport System y+; Animals; Benzoates; Brain Ischemia; Cell Death; Glutamate Plasma Mem | 2014 |
Dynamic metabolites profile of cerebral ischemia/reperfusion revealed by (1)H NMR-based metabolomics contributes to potential biomarkers.
Topics: Animals; Biomarkers; Brain Ischemia; Disease Models, Animal; Glycine; Magnetic Resonance Spectroscop | 2014 |
Glycine bidirectionally regulates ischemic tolerance via different mechanisms including NR2A-dependent CREB phosphorylation.
Topics: Animals; Brain Ischemia; Cyclic AMP Response Element-Binding Protein; Glycine; Male; Phosphorylation | 2015 |
Preconditioning effect of (S)-3,5-dihydroxyphenylglycine on ischemic injury in middle cerebral artery occluded Sprague-Dawley rats.
Topics: Animals; Brain Infarction; Brain Ischemia; Glycine; Infarction, Middle Cerebral Artery; Injections, | 2015 |
Association between Endothelial nitric oxide synthase G894T gene polymorphism and risk of ischemic stroke in North Indian population: a case-control study.
Topics: Adult; Aged; Brain Ischemia; Case-Control Studies; Female; Genetic Association Studies; Genetic Pred | 2016 |
Delta sleep-inducing peptide and Deltaran: potential approaches to antistress protection.
Topics: Action Potentials; Adrenal Glands; Animals; Brain; Brain Ischemia; Delta Sleep-Inducing Peptide; Dru | 2008 |
Neutrophil elastase inhibitor attenuates hippocampal neuronal damage after transient forebrain ischemia in rats.
Topics: Animals; Brain; Brain Ischemia; Caspase 3; Caspase 7; Cell Survival; Endothelium; Extracellular Spac | 2009 |
Release of endogenous amino acids from the hippocampus and brain stem from developing and adult mice in ischemia.
Topics: Aging; Alanine; Animals; Aspartic Acid; Brain Ischemia; Brain Stem; Female; gamma-Aminobutyric Acid; | 2009 |
Subarachnoid hemorrhage and microdialysis.
Topics: Blood Pressure; Brain Ischemia; Cerebrovascular Circulation; Databases, Factual; Energy Metabolism; | 2009 |
Response.
Topics: Blood Pressure; Brain Chemistry; Brain Ischemia; Cerebrovascular Circulation; Energy Metabolism; Gly | 2009 |
Ionic dysregulations typical of ischemia provoke release of glycine and GABA by multiple mechanisms.
Topics: Animals; Brain Ischemia; Exocytosis; gamma-Aminobutyric Acid; Glycine; Hippocampus; Mice; Mitochondr | 2010 |
Decreased vasoconstrictor responses in remote cerebral arteries after focal brain ischemia and reperfusion in the rat, in vitro.
Topics: Animals; Brain Ischemia; Cerebral Arteries; Free Radical Scavengers; Glycine; Infarction, Middle Cer | 2010 |
Neuroprotection via strychnine-sensitive glycine receptors during post-ischemic recovery of excitatory synaptic transmission in the hippocampus.
Topics: Animals; Brain Ischemia; Excitatory Postsynaptic Potentials; Glycine; Hippocampus; In Vitro Techniqu | 2010 |
[Effects of the metabotropic glutamate receptor ligand(s)-4C3HPG on the induction of brain ischemic tolerance in the rat].
Topics: Animals; Brain Ischemia; Electroencephalography; Glial Fibrillary Acidic Protein; Glycine; Ischemic | 2003 |
Effect of ginkgolide B on striatal extracellular amino acids in middle cerebral artery occluded rats.
Topics: Amino Acids; Animals; Aspartic Acid; Brain Ischemia; Corpus Striatum; gamma-Aminobutyric Acid; Ginkg | 2011 |
[Amides of creatine: perspectives of neuroprotection].
Topics: Amides; Animals; Brain Ischemia; Creatine; Female; gamma-Aminobutyric Acid; Glycine; Hemodynamics; I | 2011 |
[Study of the Toll-like receptor 4 gene polymorphisms in diseases presenting with subclinical and chronic inflammation].
Topics: Alleles; Aspartic Acid; Brain Ischemia; Chronic Disease; Cytokines; Diabetes Complications; Diabetic | 2011 |
Associations of ESR2 AluI (G/A) polymorphism with ischemic stroke in Caucasians.
Topics: Aged; Aged, 80 and over; Alanine; Alu Elements; Brain Ischemia; Estrogen Receptor beta; Female; Gene | 2012 |
A8344G mutation of the mitochondrial DNA with typical mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes syndrome.
Topics: Acidosis, Lactic; Adult; Alanine; Brain Ischemia; DNA, Mitochondrial; Glycine; Humans; Male; MELAS S | 2011 |
Glycine exerts dual roles in ischemic injury through distinct mechanisms.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain Ischemia; Dose-Response Relationship, Drug; Glucose; Gly | 2012 |
Glycine attenuates cerebral ischemia/reperfusion injury by inhibiting neuronal apoptosis in mice.
Topics: Animals; Apoptosis; Brain Ischemia; Disease Models, Animal; Glycine; Male; Mice; Mice, Inbred ICR; N | 2012 |
Mechanism underlying the protective effect of glycine in energetic disturbances in brain tissues under hypoxic conditions.
Topics: Animals; Brain; Brain Ischemia; Glycine; Hypoxia, Brain; In Vitro Techniques; Mitochondria; Rats; Re | 2012 |
Activation of mGlu1 but not mGlu5 metabotropic glutamate receptors contributes to postischemic neuronal injury in vitro and in vivo.
Topics: Animals; Brain Ischemia; Bridged Bicyclo Compounds; Cell Line; Cricetinae; Excitatory Amino Acid Ago | 2002 |
Extracellular glutamate and other amino acids in experimental intracerebral hemorrhage: an in vivo microdialysis study.
Topics: Analysis of Variance; Animals; Asparagine; Aspartic Acid; Brain Ischemia; Cerebral Hemorrhage; Chrom | 2003 |
[Significance of Factor V gene A506G mutation (Leiden) in the pathogenesis of ischemic stroke].
Topics: Adult; Age of Onset; Alanine; Brain Ischemia; DNA Mutational Analysis; Factor V; Female; Genetic Pre | 2003 |
Neuroprotective effects of bilobalide, a component of Ginkgo biloba extract (EGb 761) in global brain ischemia and in excitotoxicity-induced neuronal death.
Topics: Animals; Animals, Newborn; Brain Ischemia; Cell Count; Cell Death; Cell Survival; Cells, Cultured; C | 2003 |
Targeting ischemic stroke with a novel opener of ATP-sensitive potassium channels in the brain.
Topics: Animals; Brain; Brain Ischemia; Cells, Cultured; Disease Models, Animal; Electrophysiology; Gerbilli | 2004 |
Glycine-induced neurotoxicity in organotypic hippocampal slice cultures.
Topics: Alanine; Animals; Animals, Newborn; Brain Ischemia; Dose-Response Relationship, Drug; Drug Resistanc | 2005 |
Correction of cerebral ischemia in low-resistant animals with an antistress drug Deltaran.
Topics: Animals; Brain Ischemia; Delta Sleep-Inducing Peptide; Drug Combinations; Electroencephalography; Gl | 2006 |
[Effects of Ginkgo biloba extract against excitotoxicity induced by NMDA receptors and mechanism thereof].
Topics: Animals; Animals, Newborn; Brain Ischemia; Cell Survival; Cells, Cultured; Dizocilpine Maleate; Exci | 2006 |
Deltaran prevents an adverse effect of emotional stress on the course of cerebral ischemia in low-resistant animals.
Topics: Animals; Brain Ischemia; Delta Sleep-Inducing Peptide; Drug Combinations; Electroencephalography; Gl | 2006 |
Simultaneous determination of myo-inositol and scyllo-inositol by MEKC as a rapid monitoring tool for inositol levels.
Topics: Anhydrides; Animals; Brain Ischemia; Chromatography, Micellar Electrokinetic Capillary; Glucose; Gly | 2007 |
Lower contribution of factor V Leiden or G202104 mutations to ischemic stroke in patients with clinical risk factors: pair-matched case-control study.
Topics: Aged; Brain Ischemia; Case-Control Studies; Factor V; Female; Genotype; Glycine; Humans; Male; Match | 2007 |
Direct correlation between ischemic injury and extracellular glycine concentration in mice with genetically altered activities of the glycine cleavage multienzyme system.
Topics: Alanine; Amino Acid Oxidoreductases; Animals; Brain Ischemia; Carrier Proteins; Cerebrovascular Circ | 2007 |
[Effect of deltaran on the mediatory balance in the brain of young and old rats with left-side laterality profile in case of carotid arteries occlusion].
Topics: Aging; Animals; Arterial Occlusive Diseases; Brain; Brain Ischemia; Carotid Arteries; Delta Sleep-In | 2007 |
Role of glycine receptors and glycine release for the neuroprotective activity of bilobalide.
Topics: Animals; Binding Sites; Binding, Competitive; Brain Edema; Brain Ischemia; Chlorides; Choline; Cyclo | 2008 |
[Delta-sleep inducing peptide and the drug deltaran: possible approaches to antistress protection].
Topics: Animals; Brain Ischemia; Cerebrovascular Circulation; Delta Sleep-Inducing Peptide; Disease Models, | 2007 |
Effects of anoxia on the stimulated release of amino acid neurotransmitters in the cerebellum in vitro.
Topics: Amino Acids; Animals; Aspartic Acid; Brain Ischemia; Cerebellum; Female; gamma-Aminobutyric Acid; Gl | 1983 |
[Motor activity and the content of neuroactive amino acids in brain tissues].
Topics: Amino Acids; Animals; Aspartic Acid; Brain; Brain Ischemia; Cats; Cerebral Cortex; Female; gamma-Ami | 1983 |
Neurotransmitter amino acids in the CNS. I. Regional changes in amino acid levels in rat brain during ischemia and reperfusion.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Brain; Brain Ischemia; Cerebrovascular Circulation; ga | 1984 |
The effect of the glycine site-specific N-methyl-D-aspartate antagonist ACEA1021 on ischemic brain damage caused by acute subdural hematoma in the rat.
Topics: Animals; Binding, Competitive; Blood Pressure; Brain Ischemia; Excitatory Amino Acid Antagonists; Gl | 1995 |
Arg506Gln factor V mutation (factor V Leiden) in patients with ischaemic cerebrovascular disease and survivors of myocardial infarction.
Topics: Adult; Arginine; Brain Ischemia; Factor V; Female; Finland; Glycine; Humans; Male; Middle Aged; Myoc | 1995 |
Post-ischemic changes of [3H]glycine binding in the gerbil brain after cerebral ischemia.
Topics: Animals; Antibodies, Monoclonal; Autoradiography; Brain; Brain Ischemia; Gerbillinae; Glycine; Immun | 1995 |
Effect of hypocapnia on extracellular glutamate and glycine concentrations during peri-ischemic period in the rabbit hippocampus.
Topics: Animals; Brain Ischemia; Glutamic Acid; Glycine; Hippocampus; Hyperventilation; Hypocapnia; Potassiu | 1994 |
Isoflurane reduces ischemia-induced glutamate release in rats subjected to forebrain ischemia.
Topics: Anesthesia; Animals; Brain Ischemia; Dialysis; Dose-Response Relationship, Drug; Electroencephalogra | 1995 |
Etomidate reduces ischemia-induced glutamate release in the hippocampus in rats subjected to incomplete forebrain ischemia.
Topics: Animals; Brain Ischemia; Chromatography, High Pressure Liquid; Etomidate; Glutamic Acid; Glycine; Hi | 1995 |
A possible role for phospholipases in the release of neurotransmitter amino acids from ischemic rat cerebral cortex.
Topics: Amino Acids; Animals; Aspartic Acid; Brain Ischemia; Disease Models, Animal; gamma-Aminobutyric Acid | 1995 |
Glycine site NMDA receptor antagonists provide protection against ischemia-induced neuronal damage in hippocampal slice cultures.
Topics: Animals; Brain Ischemia; Cell Death; Dizocilpine Maleate; Glycine; Glycine Agents; Hippocampus; Kynu | 1995 |
Calcium green-5N, a novel fluorescent probe for monitoring high intracellular free Ca2+ concentrations associated with glutamate excitotoxicity in cultured rat brain neurons.
Topics: Animals; Brain Chemistry; Brain Ischemia; Calcium; Cells, Cultured; Cyanides; Fluorescent Dyes; Glut | 1993 |
In situ changes in purine nucleotide and N-acetyl concentrations upon inducing global ischemia in cat brain.
Topics: Acetylation; Adenosine; Animals; Aspartic Acid; Brain Ischemia; Cats; Choline; Creatine; Female; gam | 1993 |
Increased activation of L-type voltage-dependent calcium channels is associated with glycine enhancement of N-methyl-D-aspartate-stimulated dopamine release in global cerebral ischemia/reperfusion.
Topics: Animals; Brain Ischemia; Calcium Channels; Dogs; Dopamine; Female; Glycine; Isradipine; N-Methylaspa | 1994 |
NMDA and glycine receptor mRNA expression following transient global ischemia in the gerbil brain.
Topics: Animals; Base Sequence; Brain Ischemia; Gerbillinae; Glycine; Hippocampus; Male; Molecular Sequence | 1993 |
Effects of repeated cerebral ischemia on extracellular amino acid concentrations measured with intracerebral microdialysis in the gerbil hippocampus.
Topics: Amino Acids; Animals; Brain Ischemia; Disease Models, Animal; Extracellular Space; gamma-Aminobutyri | 1993 |
Extracellular neuroactive amino acids in the rat striatum during ischaemia: comparison between penumbral conditions and ischaemia with sustained anoxic depolarisation.
Topics: Alanine; Amino Acids; Animals; Brain Ischemia; Corpus Striatum; Dialysis; Electroencephalography; El | 1993 |
Effects of hypothermia on the rate of excitatory amino acid release after ischemic depolarization.
Topics: Analysis of Variance; Animals; Aspartic Acid; Body Temperature; Brain Ischemia; Cerebral Cortex; Ele | 1996 |
Neuroexcitatory amino acids and their relation to infarct size and neurological deficit in ischemic stroke.
Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Aspartic Acid; Brain Ischemia; Cerebral Cortex | 1996 |
Felbamate protects CA1 neurons from apoptosis in a gerbil model of global ischemia.
Topics: Animals; Anticonvulsants; Apoptosis; Brain Ischemia; Cell Death; Cell Nucleus; Cell Survival; Cytopl | 1996 |
Effects of hypothermia, pentobarbital, and isoflurane on postdepolarization amino acid release during complete global cerebral ischemia.
Topics: Anesthetics, Inhalation; Animals; Aspartic Acid; Brain Ischemia; Calcium; gamma-Aminobutyric Acid; G | 1996 |
Arg506Gln factor V mutation and cerebral ischemia in the young.
Topics: Adolescent; Adult; Aging; Arginine; Brain Ischemia; Child; Child, Preschool; Factor V; Female; Glyci | 1996 |
The role of glycine in anoxia/aglycaemia-induced potentiation of N-methyl-D-aspartate receptor-mediated postsynaptic potentials in the rat hippocampus.
Topics: Animals; Brain Ischemia; Dose-Response Relationship, Drug; Glycine; Hippocampus; Male; Membrane Pote | 1995 |
Neuroprotective effect of NMDA receptor glycine recognition site antagonism persists when brain temperature is controlled.
Topics: Animals; Binding Sites; Brain Damage, Chronic; Brain Ischemia; Cerebral Infarction; Excitatory Amino | 1997 |
Modulation of ischemic excitatory neurotransmitter and gamma-aminobutyric acid release during global temporary cerebral ischemia by selective neuronal nitric oxide synthase inhibition.
Topics: Animals; Aspartic Acid; Brain; Brain Ischemia; Excitatory Amino Acids; gamma-Aminobutyric Acid; Glut | 1997 |
Modulation of ischemic excitatory neurotransmitter and gamma-aminobutyric acid release during global temporary cerebral ischemia by local nitric oxide synthase inhibition.
Topics: Animals; Aspartic Acid; Brain; Brain Ischemia; Cerebrovascular Circulation; Chromatography, High Pre | 1997 |
[Balance of neuromediatory amino acids and impairment of integral brain activity caused by local ischemia of frontal lobe in rats: effects of piracetam and glycine].
Topics: Animals; Avoidance Learning; Brain Ischemia; Frontal Lobe; Glycine; Male; Motor Activity; Neuroprote | 1997 |
[Effect of dl-3-butylphthalide on the striatum extracellular amino acid and dopamine contents in the rat during cerebral ischemia].
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Benzofurans; Brain Ischemia; Corpus Striatum; Dopamine; Ext | 1996 |
The mGlu receptor ligand (S)-4C3HPG protects neurons after global ischaemia in gerbils.
Topics: Animals; Brain Ischemia; Drug Evaluation, Preclinical; Excitatory Amino Acid Antagonists; Gerbillina | 1998 |
Attenuated neurotransmitter release and spreading depression-like depolarizations after focal ischemia in mutant mice with disrupted type I nitric oxide synthase gene.
Topics: Alanine; Animals; Brain; Brain Ischemia; Cerebral Infarction; Cerebrovascular Circulation; Cortical | 1998 |
(1S,3R)-ACPD, a metabotropic glutamate receptor agonist, enhances damage after global ischaemia.
Topics: Animals; Benzoates; Brain Ischemia; Cell Count; Cell Survival; Cycloleucine; Dose-Response Relations | 1999 |
[Levels of neurotransmitter amino acids in the cerebrospinal fluid of patients with acute ischemic stroke].
Topics: Acute Disease; Aspartic Acid; Brain Ischemia; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glycin | 1999 |
Metabotropic glutamate receptors and cell-type-specific vulnerability in the striatum: implication for ischemia and Huntington's disease.
Topics: Animals; Brain Ischemia; Calcium Channels; Cell Communication; Cells, Cultured; Cerebral Cortex; Cho | 1999 |
Substituted analogues of GV150526 as potent glycine binding site antagonists in animal models of cerebral ischemia.
Topics: Animals; Anticonvulsants; Binding Sites; Brain Ischemia; Carboxylic Acids; Cerebral Infarction; Dise | 1999 |
Hyperglycemia enhances extracellular glutamate accumulation in rats subjected to forebrain ischemia.
Topics: Alanine; Animals; Brain Ischemia; Glutamic Acid; Glutamine; Glycine; Hyperglycemia; Male; Prosenceph | 2000 |
Excitotoxic cell death dependent on inhibitory receptor activation.
Topics: Action Potentials; Animals; Bicuculline; Brain Ischemia; Cell Hypoxia; Cells, Cultured; Cerebellar C | 1999 |
Distinct influence of the group III metabotropic glutamate receptor agonist (R,S)-4-phosphonophenylglycine [(R,S)-PPG] on different forms of neuronal damage.
Topics: Action Potentials; Animals; Brain Diseases; Brain Ischemia; Cell Hypoxia; Corpus Striatum; Cytoprote | 2000 |
Neutrophil elastase inhibition reduces cerebral ischemic damage in the middle cerebral artery occlusion.
Topics: Animals; Antilymphocyte Serum; Brain Edema; Brain Ischemia; Cell Count; Cerebral Cortex; Corpus Stri | 2000 |
Blocking the glycine-binding site of NMDA receptors prevents the progression of ischemic pathology induced by bilateral carotid artery occlusion in spontaneously hypertensive rats.
Topics: Animals; Binding Sites; Body Temperature; Body Water; Brain Ischemia; Carotid Artery Thrombosis; Dis | 2000 |
Influence of different anaesthetics on extracellular aminoacids in rat brain.
Topics: Amino Acids; Anesthetics; Animals; Aspartic Acid; Brain; Brain Chemistry; Brain Ischemia; Extracellu | 2000 |
Involvement of metabotropic glutamate receptors in ischemia-induced taurine release in the developing and adult hippocampus.
Topics: Aging; Animals; Brain Ischemia; Cycloleucine; Cyclopropanes; Excitatory Amino Acid Agonists; Excitat | 2000 |
Neuroprotection by group I metabotropic glutamate receptor antagonists in forebrain ischemia of gerbil.
Topics: Animals; Arachidonic Acid; Benzoates; Brain; Brain Ischemia; Cell Survival; Excitatory Amino Acid An | 2000 |
Hypothermia inhibits ischemia-induced efflux of amino acids and neuronal damage in the hippocampus of aged rats.
Topics: Aging; Alanine; Amino Acids; Animals; Aspartic Acid; Brain Ischemia; Cerebrovascular Circulation; Ex | 2000 |
Excitatory amino acid concentrations in ventricular cerebrospinal fluid after severe traumatic brain injury in infants and children: the role of child abuse.
Topics: Adolescent; Age Factors; Aspartic Acid; Brain Injuries; Brain Ischemia; Case-Control Studies; Cerebr | 2001 |
Real-time, two-dimensional visualization of ischaemia-induced glutamate release from hippocampal slices.
Topics: Alanine; Aspartic Acid; Brain Ischemia; Calcium Signaling; Cell Line; Computer Systems; Dentate Gyru | 2001 |
Novel synthetic analogue of ACTH 4-10 (Semax) but not glycine prevents the enhanced nitric oxide generation in cerebral cortex of rats with incomplete global ischemia.
Topics: Adrenocorticotropic Hormone; Animals; Brain Ischemia; Cerebral Cortex; Glycine; Lipid Peroxidation; | 2001 |
Pharmacology and neuroprotective actions of mGlu receptor ligands.
Topics: Amino Acids; Brain; Brain Ischemia; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocycl | 2001 |
Matrix metalloproteinase inhibitor KB-R7785 attenuates brain damage resulting from permanent focal cerebral ischemia in mice.
Topics: Animals; Brain; Brain Ischemia; Cerebral Infarction; Glycine; Hydroxamic Acids; Male; Matrix Metallo | 2001 |
Alterations of amino acid levels from striatum, hippocampus, and cerebral cortex induced by global cerebral ischemia in gerbil.
Topics: Animals; Brain; Brain Ischemia; Cerebral Cortex; Corpus Striatum; Excitatory Amino Acid Antagonists; | 2000 |
Characteristics of hippocampal glycine release in cell-damaging conditions in the adult and developing mouse.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfo | 2001 |
[Effect of guizhi fuling pills on the changes of Ca2+ and amino acids in rats with cerebral ischemia and reperfusion].
Topics: Animals; Brain; Brain Ischemia; Calcium; Drug Combinations; Drugs, Chinese Herbal; Female; gamma-Ami | 1998 |
Selective mGluR5 receptor antagonist or agonist provides neuroprotection in a rat model of focal cerebral ischemia.
Topics: Animals; Body Temperature; Body Weight; Brain Ischemia; Cell Survival; Cerebral Cortex; Disease Mode | 2001 |
Neuroprotection in cerebral ischemia by neutralization of 3-aminopropanal.
Topics: Aldehydes; Animals; Antioxidants; Brain; Brain Ischemia; Cell Line; Cells, Cultured; Disease Models, | 2002 |
The effect of cyclohexyladenosine on the periischemic increases of hippocampal glutamate and glycine in the rabbit.
Topics: Adenosine; Animals; Brain Ischemia; Glutamates; Glutamic Acid; Glycine; Hippocampus; Rabbits | 1992 |
Differing neurochemical and morphological sequelae of global ischemia: comparison of single- and multiple-insult paradigms.
Topics: Analysis of Variance; Animals; Brain Chemistry; Brain Ischemia; Chromatography, High Pressure Liquid | 1992 |
[Changes in EEG and higher nervous activity of rats during cerebral anti-ischemic protection by acelysin].
Topics: Animals; Anti-Infective Agents; Aspirin; Brain; Brain Ischemia; Conditioning, Classical; Drug Combin | 1992 |
The effects of hypothermia on amino acid neurotransmitter release from the cerebral cortex.
Topics: Animals; Aspartic Acid; Brain Ischemia; Cerebral Cortex; gamma-Aminobutyric Acid; Glutamates; Glutam | 1991 |
Intra- and extracellular changes of amino acids in the cerebral cortex of the neonatal rat during hypoxic-ischemia.
Topics: Amino Acids; Animals; Animals, Newborn; Brain Ischemia; Cerebral Cortex; Energy Metabolism; Extracel | 1991 |
NMDA receptors trigger excitement.
Topics: Aspartic Acid; Brain; Brain Ischemia; Cell Survival; Cerebrovascular Disorders; Electrophysiology; G | 1988 |