glycine has been researched along with Aura in 98 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "Genetic disorders of gamma-aminobutyric acid (GABA), glycine, and serine metabolism and of the GABA and glycine receptors are causes of epilepsy with variable responsiveness to treatment." | 8.81 | Genetic disorders of gamma-aminobutyric acid, glycine, and serine as causes of epilepsy. ( Jaeken, J, 2002) |
| "The development of bicuculline- and allylglycine-induced epilepsy has been studied in developing rats (6 to 30 days old)." | 7.67 | Bicuculline- and allylglycine-induced epilepsy in developing rats. ( de Feo, MR; Mecarelli, O; Ricci, GF, 1985) |
| "Amino acid analysis of plasma and urine obtained from 12 patients with epilepsy indicated that the plasma concentrations of taurine and glutamic acid were much higher than might have been expected." | 7.65 | Biochemical observations following administration of taurine to patients with epilepsy. ( Anderman, F; Sacks, C; Sherwin, AL; Van Gelder, NM, 1975) |
| "Generalised clonic--tonic seizures were completely suppressed and the metabolic changes were markedly ameliorated, there being only a 1." | 5.31 | Attenuation of seizures induced by homocysteic acid in immature rats by metabotropic glutamate group II and group III receptor agonists. ( Folbergrová, J; Haugvicová, R; Mares, P, 2001) |
| "Genetic disorders of gamma-aminobutyric acid (GABA), glycine, and serine metabolism and of the GABA and glycine receptors are causes of epilepsy with variable responsiveness to treatment." | 4.81 | Genetic disorders of gamma-aminobutyric acid, glycine, and serine as causes of epilepsy. ( Jaeken, J, 2002) |
| " Continuous microperfusion of the antagonist for the glycine binding site in NMDA receptors 5,7-dichlorokynurenic acid (100 microM) reversed the effect of both glutamate (1 mM) and glycine (1 mM) and suppressed seizures completely in 90% of the animals." | 3.71 | Effect of extracellular long-time microperfusion of high concentrations of glutamate and glycine on picrotoxin seizure thresholds in the hippocampus of freely moving rats. ( Senra-Vidal, A; Sierra-Marcuño, G; Sierra-Paredes, G, 2001) |
| "In mice VGD afforded complete protection against maximal electroshock (MES)-, pentylenetetrazole-, picrotoxin-, and bicuculline-induced seizures and 6-Hz "psychomotor" seizures with median effective dose (ED50) values of 151, 132, 275, 248, and 237 mg/kg, respectively." | 3.71 | Anticonvulsant profile of valrocemide (TV1901): a new antiepileptic drug. ( Bialer, M; Isoherranen, N; White, HS; Woodhead, JH, 2001) |
| "We report a patient with neonatal epilepsy, with no pattern of burst-suppression, secondary to the transient form of nonketotic hyperglycinemia." | 3.69 | [Non-ketotic hyperglycinemia. Transient neonatal form]. ( Alejo, J; Cardesa, JJ; Gómez Martín, H; Rincón, P; Sánchez Alarcón, J; Vaquerizo, J, 1996) |
| "The anticonvulsant activity of (S)-4-carboxy-3-hydroxyphenylglycine ((S)-4C3HPG) (an antagonist of Group I and an agonist of Group II metabotropic glutamate (mGlu) receptors), of (1S,3S)-1-aminocyclopentane-1,3-dicarboxylic acid ((1S,3S)-ACPD) (an agonist of Group II mGlu receptors), and of L-serine-O-phosphate (an agonist of Group III mGlu receptors) was studied against sound-induced seizures in genetically epilepsy-prone (GEP) rats following bilateral microinjection into the inferior colliculus." | 3.69 | Prolonged anticonvulsant action of glutamate metabotropic receptor agonists in inferior colliculus of genetically epilepsy-prone rats. ( Chapman, AG; Jane, DE; Meldrum, BS; Tang, E; Yip, PK, 1997) |
| "We studied the CSF amino acid levels of 42 patients with newly diagnosed epilepsy before treatment with antiepileptic medication and during monotherapy with either vigabatrin or carbamazepine." | 3.68 | Amino acid levels in the cerebrospinal fluid of newly diagnosed epileptic patients: effect of vigabatrin and carbamazepine monotherapies. ( Halonen, T; Kälviäinen, R; Pitkänen, A; Riekkinen, PJ, 1993) |
| "The development of bicuculline- and allylglycine-induced epilepsy has been studied in developing rats (6 to 30 days old)." | 3.67 | Bicuculline- and allylglycine-induced epilepsy in developing rats. ( de Feo, MR; Mecarelli, O; Ricci, GF, 1985) |
| "Amino acid analysis of plasma and urine obtained from 12 patients with epilepsy indicated that the plasma concentrations of taurine and glutamic acid were much higher than might have been expected." | 3.65 | Biochemical observations following administration of taurine to patients with epilepsy. ( Anderman, F; Sacks, C; Sherwin, AL; Van Gelder, NM, 1975) |
| " So far it is not clear whether NMDA receptor antagonists including glycine antagonists would be suitable for chronic administration because of their effects on cognition, learning and motor function." | 2.40 | The glycine site on the NMDA receptor: structure-activity relationships and possible therapeutic applications. ( Dannhardt, G; Kohl, BK, 1998) |
| " Their beneficial effects decline with chronic administration because of drug tolerance, and the theoretical basis for BDZ responses remains unclear." | 2.38 | Myoclonus: analysis of monoamine, GABA, and other systems. ( Snodgrass, SR, 1990) |
| "Prolonged neonatal febrile seizures (FSs) often lead to cognitive decline and increased risk of psychopathology in adulthood." | 1.72 | Prolonged Febrile Seizures Impair Synaptic Plasticity and Alter Developmental Pattern of Glial Fibrillary Acidic Protein (GFAP)-Immunoreactive Astrocytes in the Hippocampus of Young Rats. ( Griflyuk, AV; Postnikova, TY; Zaitsev, AV, 2022) |
| "Several of these syndromes are associated with an encephalopathy that characteristically shows episodes of rapid neurological deterioration and the development of acute cerebral lesions." | 1.36 | Localized cerebral energy failure in DNA polymerase gamma-associated encephalopathy syndromes. ( Bindoff, LA; Engelsen, BE; Ersland, L; Moen, G; Mørk, SJ; Neckelmann, G; Tzoulis, C; Viscomi, C; Zeviani, M, 2010) |
| "Treatment with creatine monohydrate, to enhance cerebral creatine transport, combined with L-arginine and L-glycine, to enhance cerebral creatine synthesis, resulted in complete resolution of seizures." | 1.36 | Treatment of intractable epilepsy in a female with SLC6A8 deficiency. ( Casey, B; Connolly, MB; Davis, C; Horvath, GA; Jakobs, C; Lowry, N; Mercimek-Mahmutoglu, S; Poskitt, KJ; Salomons, GS; Sinclair, G; Stockler-Ipsiroglu, S, 2010) |
| "Generalised clonic--tonic seizures were completely suppressed and the metabolic changes were markedly ameliorated, there being only a 1." | 1.31 | Attenuation of seizures induced by homocysteic acid in immature rats by metabotropic glutamate group II and group III receptor agonists. ( Folbergrová, J; Haugvicová, R; Mares, P, 2001) |
| "Valproic acid (VPA) is an antiepileptic drug widely used in paediatrics." | 1.30 | [Evaluation of the effect of long term valproic acid treatment on plasma levels of carnitine, ammonia and amino acids related to the urea cycle in pediatric epileptic patients]. ( Jiménez, C; Lluch-Fernández, MD; Marchante-Serrano, C; Navarro-Quesada, FJ; Vaquero-Abellán, M, 1997) |
| "1 Lh-1 (mean +/- SD), a volume of distribution (Vss) of 15 +/- 2 L, and a half-life (t1/2) of 1." | 1.30 | Pharmacokinetic analysis and antiepileptic activity of two new isomers of N-valproyl glycinamide. ( Bialer, M; Hadad, S, 1997) |
| "Pregnancy is associated with a significant alteration of NMDA and non-NMDA receptor binding in rats." | 1.30 | N-methyl-D-aspartate receptor binding is altered and seizure potential reduced in pregnant rats. ( Standley, CA, 1999) |
| "Kynurenic acid (KYNA) is an antagonist of (+/-)-alpha-amino-3-hydroxy-5-methylisoxazole-4-proprionic acid (AMPA) and N-methyl-D-aspartate (NMDA) receptors and it blocks the glycine site of the NMDA receptor preferentially (IC50 = 7." | 1.30 | Quantitative differences in the effects of de novo produced and exogenous kynurenic acid in rat brain slices. ( Hodgkins, PS; Lee, SC; Scharfman, HE; Schwarcz, R, 1999) |
| "L-Allylglycine treatment led to a substantial decrease in the concentration of detectable GABA-immunoreactive bouton-like dots in the stratum oriens, radiatum and lacunosum-moleculare and in the deep hilar region, but did not produce statistically significant changes in this parameter in the outer and intermediate zones of the dentate molecular layer." | 1.27 | Redistribution of transmitter amino acids in rat hippocampus and cerebellum during seizures induced by L-allylglycine and bicuculline: an immunocytochemical study with antisera against conjugated GABA, glutamate and aspartate. ( Meldrum, BS; Ottersen, OP; Storm-Mathisen, J; Swan, JH, 1987) |
| "In mice showing sound induced seizures, clobazam, 1--4 mg/kg, i." | 1.26 | Anticonvulsant action of a 1,5-benzodiazepine, clobazam, in reflex epilepsy. ( Chapman, AG; Horton, RW; Meldrum, BS, 1978) |
| "Hyperglycinemia was induced by dipropylacetate (DPA) (dose 14-41 mg/kg per day) in 10 Finnish epileptic patients with neurologically disabling diseases of various kinds." | 1.26 | Dipropylacetate and hyperglycinemia. ( Huhtaniemi, I; Linna, SL; Saukkonen, AL; Similä, S; von Wendt, L, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 31 (31.63) | 18.7374 |
| 1990's | 22 (22.45) | 18.2507 |
| 2000's | 31 (31.63) | 29.6817 |
| 2010's | 12 (12.24) | 24.3611 |
| 2020's | 2 (2.04) | 2.80 |
| Authors | Studies |
|---|---|
| Ahmad, S | 1 |
| Aamir, M | 1 |
| Kirmani, SI | 1 |
| Haroon, ZH | 1 |
| Munir, MU | 1 |
| Khalid, UB | 1 |
| Griflyuk, AV | 1 |
| Postnikova, TY | 1 |
| Zaitsev, AV | 1 |
| Swanson, MA | 1 |
| Garcia, SM | 1 |
| Spector, E | 1 |
| Kronquist, K | 1 |
| Creadon-Swindell, G | 1 |
| Walter, M | 1 |
| Christensen, E | 1 |
| Van Hove, JLK | 1 |
| Sass, JO | 1 |
| Almannai, M | 1 |
| El-Hattab, AW | 1 |
| Amin, JB | 1 |
| Leng, X | 1 |
| Gochman, A | 1 |
| Zhou, HX | 1 |
| Wollmuth, LP | 1 |
| Chen, R | 1 |
| Okabe, A | 1 |
| Sun, H | 1 |
| Sharopov, S | 1 |
| Hanganu-Opatz, IL | 1 |
| Kolbaev, SN | 1 |
| Fukuda, A | 1 |
| Luhmann, HJ | 2 |
| Kilb, W | 1 |
| de Kovel, CG | 1 |
| Meisler, MH | 1 |
| Brilstra, EH | 1 |
| van Berkestijn, FM | 1 |
| van 't Slot, R | 1 |
| van Lieshout, S | 1 |
| Nijman, IJ | 1 |
| O'Brien, JE | 1 |
| Hammer, MF | 1 |
| Estacion, M | 1 |
| Waxman, SG | 1 |
| Dib-Hajj, SD | 1 |
| Koeleman, BP | 1 |
| Schimmenti, LA | 1 |
| Addis, L | 1 |
| Virdee, JK | 1 |
| Vidler, LR | 1 |
| Collier, DA | 1 |
| Pal, DK | 1 |
| Ursu, D | 1 |
| Fuortes, MG | 1 |
| Faria, LC | 1 |
| Merlin, LR | 4 |
| Garrido-Sanabria, ER | 1 |
| Otalora, LF | 1 |
| Arshadmansab, MF | 1 |
| Herrera, B | 1 |
| Francisco, S | 1 |
| Ermolinsky, BS | 1 |
| Radwan, NM | 1 |
| El Hay Ahmed, NA | 1 |
| Ibrahim, KM | 1 |
| Khedr, ME | 1 |
| Aziz, MA | 1 |
| Khadrawy, YA | 1 |
| Eminoglu, FT | 1 |
| Ozcelik, AA | 1 |
| Okur, I | 1 |
| Tumer, L | 1 |
| Biberoglu, G | 1 |
| Demir, E | 1 |
| Hasanoglu, A | 1 |
| Baumgartner, MR | 1 |
| Maciejak, P | 1 |
| Szyndler, J | 1 |
| Turzyńska, D | 1 |
| Sobolewska, A | 1 |
| Taracha, E | 1 |
| Skórzewska, A | 1 |
| Lehner, M | 1 |
| Bidziński, A | 1 |
| Hamed, A | 1 |
| Wisłowska-Stanek, A | 1 |
| Płaźnik, A | 1 |
| Tzoulis, C | 1 |
| Neckelmann, G | 1 |
| Mørk, SJ | 1 |
| Engelsen, BE | 1 |
| Viscomi, C | 1 |
| Moen, G | 1 |
| Ersland, L | 1 |
| Zeviani, M | 1 |
| Bindoff, LA | 1 |
| Mercimek-Mahmutoglu, S | 2 |
| Connolly, MB | 1 |
| Poskitt, KJ | 1 |
| Horvath, GA | 1 |
| Lowry, N | 1 |
| Salomons, GS | 2 |
| Casey, B | 1 |
| Sinclair, G | 1 |
| Davis, C | 1 |
| Jakobs, C | 3 |
| Stockler-Ipsiroglu, S | 2 |
| Patino, GA | 1 |
| Brackenbury, WJ | 1 |
| Bao, Y | 1 |
| Lopez-Santiago, LF | 1 |
| O'Malley, HA | 1 |
| Chen, C | 1 |
| Calhoun, JD | 1 |
| Lafrenière, RG | 1 |
| Cossette, P | 1 |
| Rouleau, GA | 1 |
| Isom, LL | 1 |
| Mayr, JA | 1 |
| Zimmermann, FA | 1 |
| Fauth, C | 1 |
| Bergheim, C | 1 |
| Meierhofer, D | 1 |
| Radmayr, D | 1 |
| Zschocke, J | 1 |
| Koch, J | 1 |
| Sperl, W | 1 |
| Filatova, YB | 1 |
| Voronina, TA | 1 |
| Klodt, PM | 1 |
| Kudrin, VS | 2 |
| Nerobkova, LN | 1 |
| Rider, FK | 1 |
| Avakyan, GN | 1 |
| Rutecki, PA | 2 |
| Sayin, U | 1 |
| Yang, Y | 1 |
| Hadar, E | 1 |
| Lee, AC | 1 |
| Wong, RK | 3 |
| Chuang, SC | 2 |
| Shin, HS | 2 |
| Bianchi, R | 2 |
| Jaeken, J | 2 |
| Stoop, R | 1 |
| Conquet, F | 1 |
| Pralong, E | 1 |
| Lea, PM | 1 |
| Sarvey, JM | 1 |
| Kirchner, A | 1 |
| Breustedt, J | 1 |
| Rosche, B | 1 |
| Heinemann, UF | 1 |
| Schmieden, V | 1 |
| Rico, MJ | 1 |
| Shirayama, Y | 1 |
| Takahashi, S | 1 |
| Minabe, Y | 1 |
| Ogino, T | 1 |
| Vázquez-López, A | 1 |
| Sierra-Paredes, G | 2 |
| Sierra-Marcuño, G | 2 |
| Klepper, J | 1 |
| Salas-Burgos, A | 1 |
| Gertsen, E | 1 |
| Fischbarg, J | 1 |
| Stoeckler-Ipsiroglu, S | 1 |
| Adami, A | 1 |
| Appleton, R | 1 |
| Araújo, HC | 1 |
| Duran, M | 1 |
| Ensenauer, R | 1 |
| Fernandez-Alvarez, E | 1 |
| Garcia, P | 1 |
| Grolik, C | 1 |
| Item, CB | 1 |
| Leuzzi, V | 1 |
| Marquardt, I | 1 |
| Mühl, A | 1 |
| Saelke-Kellermann, RA | 1 |
| Schulze, A | 1 |
| Surtees, R | 1 |
| van der Knaap, MS | 2 |
| Vasconcelos, R | 1 |
| Verhoeven, NM | 2 |
| Vilarinho, L | 1 |
| Wilichowski, E | 1 |
| Wang, S | 1 |
| Ding, M | 1 |
| Wu, D | 1 |
| Zhan, J | 1 |
| Chen, Z | 1 |
| Karr, L | 1 |
| Avoli, M | 1 |
| Woodbury, DM | 1 |
| Roach, ES | 2 |
| Carlin, L | 1 |
| Herbert, V | 1 |
| Gibson, P | 1 |
| Haidukewych, D | 1 |
| Rodin, EA | 1 |
| Freed, WJ | 1 |
| Bonhaus, DW | 1 |
| Lippincott, SE | 1 |
| Huxtable, RJ | 1 |
| van Gelder, NM | 4 |
| Janjua, NA | 1 |
| Metrakos, K | 1 |
| MacGibbon, B | 1 |
| Metrakos, JD | 1 |
| Martín, A | 1 |
| Benavides, J | 1 |
| Ugarte, M | 1 |
| Rojik, I | 1 |
| Fehér, O | 1 |
| Cherubini, E | 1 |
| Bernardi, G | 1 |
| Stanzione, P | 1 |
| Marciani, MG | 1 |
| Mercuri, N | 1 |
| Arvanov, VL | 1 |
| Holmes, KH | 1 |
| Keele, NB | 3 |
| Shinnick-Gallagher, P | 3 |
| Rundfeldt, C | 1 |
| Wlaź, P | 1 |
| Löscher, W | 2 |
| Monaco, F | 1 |
| Gianelli, M | 1 |
| Schiavella, MP | 1 |
| Naldi, P | 1 |
| Cantello, R | 1 |
| Torta, R | 1 |
| Verzé, L | 1 |
| Mutani, R | 1 |
| Kälviäinen, R | 1 |
| Halonen, T | 1 |
| Pitkänen, A | 1 |
| Riekkinen, PJ | 1 |
| Hamberger, A | 1 |
| Haglid, K | 1 |
| Nyström, B | 1 |
| Silfvenius, H | 1 |
| Vaquerizo, J | 1 |
| Rincón, P | 1 |
| Sánchez Alarcón, J | 1 |
| Gómez Martín, H | 1 |
| Alejo, J | 1 |
| Cardesa, JJ | 1 |
| Tang, E | 1 |
| Yip, PK | 1 |
| Chapman, AG | 2 |
| Jane, DE | 1 |
| Meldrum, BS | 6 |
| Navarro-Quesada, FJ | 1 |
| Lluch-Fernández, MD | 1 |
| Vaquero-Abellán, M | 1 |
| Marchante-Serrano, C | 1 |
| Jiménez, C | 1 |
| Hadad, S | 1 |
| Bialer, M | 2 |
| Dannhardt, G | 1 |
| Kohl, BK | 1 |
| Bergold, PJ | 1 |
| DeLorenzo, RJ | 1 |
| Pal, S | 1 |
| Sombati, S | 1 |
| Neugebauer, V | 2 |
| Kardos, J | 1 |
| Standley, CA | 1 |
| Scharfman, HE | 1 |
| Hodgkins, PS | 1 |
| Lee, SC | 1 |
| Schwarcz, R | 1 |
| Thio, LL | 1 |
| Wong, M | 1 |
| Yamada, KA | 1 |
| Zinebi, F | 1 |
| Maaswinkel-Mooij, P | 1 |
| Pouwels, PJ | 1 |
| Onkenhout, W | 1 |
| Peeters, EA | 1 |
| Rogawski, MA | 1 |
| Wasterlain, CG | 1 |
| Mazarati, AM | 1 |
| Dzhala, VI | 1 |
| Ben-Ari, Y | 1 |
| Senra-Vidal, A | 1 |
| Karnup, S | 1 |
| Stelzer, A | 1 |
| Villetti, G | 1 |
| Bregola, G | 1 |
| Bassani, F | 1 |
| Bergamaschi, M | 1 |
| Rondelli, I | 1 |
| Pietra, C | 1 |
| Simonato, M | 1 |
| Folbergrová, J | 1 |
| Haugvicová, R | 1 |
| Mares, P | 1 |
| Kim, D | 1 |
| Isoherranen, N | 1 |
| Woodhead, JH | 1 |
| White, HS | 1 |
| Raevskiĭ, KS | 1 |
| Avakian, GN | 1 |
| Nesterova, SI | 1 |
| Gusev, EI | 1 |
| Corbeel, L | 1 |
| Casaer, P | 1 |
| Carchon, H | 1 |
| Eggermont, E | 1 |
| Eeckels, R | 1 |
| Horton, RW | 2 |
| Similä, S | 2 |
| von Wendt, L | 2 |
| Hartikainen-Sorri, AL | 1 |
| Kääpä, P | 1 |
| Saukkonen, AL | 2 |
| Linna, SL | 1 |
| Huhtaniemi, I | 1 |
| Sherwin, AL | 2 |
| Sacks, C | 1 |
| Anderman, F | 1 |
| Papy, JJ | 1 |
| Toure, MF | 1 |
| Brierley, JB | 2 |
| Anlezark, G | 1 |
| Balzamo, E | 1 |
| Trimble, M | 1 |
| Bowery, NG | 1 |
| Fletcher, AE | 1 |
| Price, GW | 1 |
| Ransom, R | 1 |
| Wilkin, GP | 1 |
| Wong, EH | 1 |
| Shiraga, H | 1 |
| Watanabe, Y | 1 |
| Mori, A | 1 |
| Kawasaki, H | 1 |
| Itoh, M | 1 |
| Nakahara, T | 1 |
| Fukahori, M | 1 |
| Akazawa, K | 1 |
| Mitrovic, N | 1 |
| Caboche, J | 1 |
| Carré, JB | 1 |
| Besson, MJ | 1 |
| Maurin, Y | 1 |
| Gunawan, S | 1 |
| Walton, NY | 1 |
| Treiman, DM | 1 |
| Snodgrass, SR | 1 |
| Ward, TN | 1 |
| Smith, EB | 1 |
| Reeves, AG | 1 |
| Smith, CC | 1 |
| Bowen, DM | 1 |
| Francis, PT | 1 |
| Snowden, JS | 1 |
| Neary, D | 1 |
| Swan, JH | 1 |
| Ottersen, OP | 1 |
| Storm-Mathisen, J | 1 |
| Moura-Ribeiro, MV | 1 |
| Ferlin, ML | 1 |
| Gallina, RA | 1 |
| Funayama, CA | 1 |
| Fernandes, RM | 1 |
| de Feo, MR | 1 |
| Mecarelli, O | 1 |
| Ricci, GF | 1 |
| McGeer, PL | 1 |
| McGeer, EG | 1 |
| Rasmussen, T | 1 |
| Courtois, A | 1 |
| Mollica, F | 1 |
| Pavone, L | 1 |
| Antener, I | 1 |
| Ionasescu, V | 1 |
| Stegink, L | 1 |
| Mueller, S | 1 |
| Weinstein, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Taurine as an Anti-Manic Agent: A Double-Blind, Placebo-Controlled Study in Adolescents With Bipolar Disorder[NCT00391001] | Phase 1 | 4 participants (Actual) | Interventional | 2006-02-28 | Terminated | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for glycine and Aura
| Article | Year |
|---|---|
Inborn Errors of Metabolism with Seizures: Defects of Glycine and Serine Metabolism and Cofactor-Related Disorders.
Topics: Child; Child, Preschool; Coenzymes; Diagnosis, Differential; Epilepsy; Glycine; Humans; Infant; Infa | 2018 |
Genetic disorders of gamma-aminobutyric acid, glycine, and serine as causes of epilepsy.
Topics: Amino Acid Metabolism, Inborn Errors; Epilepsy; Female; gamma-Aminobutyric Acid; Glycine; Humans; In | 2002 |
The glycine site on the NMDA receptor: structure-activity relationships and possible therapeutic applications.
Topics: Alzheimer Disease; Animals; Binding Sites; Cerebrovascular Disorders; Epilepsy; Glycine; Humans; Neu | 1998 |
Recent advances in GABA research.
Topics: Animals; Brain Chemistry; Epilepsy; gamma-Aminobutyric Acid; Glycine; Humans; Receptors, GABA; Resea | 1999 |
Myoclonus: analysis of monoamine, GABA, and other systems.
Topics: Animals; Biogenic Amines; Epilepsy; gamma-Aminobutyric Acid; Glycine; Humans; Myoclonus; Neurons; Re | 1990 |
Neurotransmitter synthetic enzymes.
Topics: Acetylcholine; Acetyltransferases; Adenylyl Cyclases; Aging; Aminobutyrates; Animals; Brain; Brain C | 1973 |
92 other studies available for glycine and Aura
| Article | Year |
|---|---|
Association of Therapeutic Dose of Valproic Acid and Plasma Glycine Levels in Epileptic Patients.
Topics: Anticonvulsants; Cross-Sectional Studies; Epilepsy; Glycine; Humans; Valproic Acid | 2021 |
Prolonged Febrile Seizures Impair Synaptic Plasticity and Alter Developmental Pattern of Glial Fibrillary Acidic Protein (GFAP)-Immunoreactive Astrocytes in the Hippocampus of Young Rats.
Topics: Animals; Astrocytes; Epilepsy; Glial Fibrillary Acidic Protein; Glycine; Hippocampus; Neuronal Plast | 2022 |
d-Glyceric aciduria does not cause nonketotic hyperglycinemia: A historic co-occurrence.
Topics: Amino Acid Oxidoreductases; Aminomethyltransferase; Carrier Proteins; Diagnosis, Differential; Epile | 2017 |
A conserved glycine harboring disease-associated mutations permits NMDA receptor slow deactivation and high Ca
Topics: Animals; Brain Diseases; Calcium; Cell Membrane Permeability; Child; Child, Preschool; Developmental | 2018 |
Activation of glycine receptors modulates spontaneous epileptiform activity in the immature rat hippocampus.
Topics: Animals; Animals, Newborn; Anticonvulsants; Cells, Cultured; Epilepsy; Glycine; Hippocampus; Rats; R | 2014 |
Characterization of a de novo SCN8A mutation in a patient with epileptic encephalopathy.
Topics: Arginine; Child, Preschool; Epilepsy; Female; Glycine; HEK293 Cells; Humans; Membrane Potentials; Mi | 2014 |
Keep Swimming Toward Precision Medicine Discoveries.
Topics: Anemia, Sideroblastic; Animals; Epilepsy; Folic Acid; Glycine; Hearing Loss; Humans; Precision Medic | 2016 |
Epilepsy-associated GRIN2A mutations reduce NMDA receptor trafficking and agonist potency - molecular profiling and functional rescue.
Topics: Blotting, Western; Calcium; Epilepsy; Gene Expression Profiling; Glutamates; Glycine; HEK293 Cells; | 2017 |
Impact of protein kinase C activation on epileptiform activity in the hippocampal slice.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Acetylcholine; Action Potentials; | 2008 |
Impaired expression and function of group II metabotropic glutamate receptors in pilocarpine-treated chronically epileptic rats.
Topics: Animals; Anticonvulsants; Blotting, Western; Brain; Chronic Disease; Convulsants; Cyclopropanes; Epi | 2008 |
Effect of infrared laser irradiation on amino acid neurotransmitters in an epileptic animal model induced by pilocarpine.
Topics: Alanine Transaminase; Amino Acids; Analysis of Variance; Animals; Aspartate Aminotransferases; Aspar | 2009 |
3-Methylcrotonyl-CoA carboxylase deficiency: phenotypic variability in a family.
Topics: Adult; Brain; Carbon-Carbon Ligases; Carnitine; Cells, Cultured; Child, Preschool; DNA Mutational An | 2009 |
The effects of group III mGluR ligands on pentylenetetrazol-induced kindling of seizures and hippocampal amino acids concentration.
Topics: Alanine; Amino Acids; Aminobutyrates; Animals; Convulsants; Disease Models, Animal; Dose-Response Re | 2009 |
Localized cerebral energy failure in DNA polymerase gamma-associated encephalopathy syndromes.
Topics: Arginine; Brain; Brain Diseases; Cerebellum; Cysteine; Diffuse Cerebral Sclerosis of Schilder; Diffu | 2010 |
Treatment of intractable epilepsy in a female with SLC6A8 deficiency.
Topics: Arginine; Child; Creatine; Drug Therapy, Combination; Epilepsy; Female; Glycine; Heterozygote; Human | 2010 |
Voltage-gated Na+ channel β1B: a secreted cell adhesion molecule involved in human epilepsy.
Topics: Amino Acid Sequence; Animals; Animals, Newborn; Arginine; Biotinylation; Cell Adhesion Molecules; Ce | 2011 |
Lipoic acid synthetase deficiency causes neonatal-onset epilepsy, defective mitochondrial energy metabolism, and glycine elevation.
Topics: Abnormalities, Multiple; Acidosis, Lactic; Amino Acid Sequence; Base Sequence; Chromosomes, Human, P | 2011 |
Changes in the levels of inhibitory and excitatory amino acids in the brain structures of female rats with cobalt epileptogenic focus during different phases of the estrous cycle.
Topics: Animals; Animals, Outbred Strains; Aspartic Acid; Cobalt; Epilepsy; Estrous Cycle; Excitatory Amino | 2011 |
Determinants of ictal epileptiform patterns in the hippocampal slice.
Topics: Animals; Calcium; Calcium Channels, L-Type; Dantrolene; Electrophysiology; Enzyme Inhibitors; Epilep | 2002 |
Role of synaptic metabotropic glutamate receptors in epileptiform discharges in hippocampal slices.
Topics: 4-Aminopyridine; Action Potentials; Animals; Benzoates; Bicuculline; Epilepsy; Excitatory Amino Acid | 2002 |
Determination of group I metabotropic glutamate receptor subtypes involved in the frequency of epileptiform activity in vitro using mGluR1 and mGluR5 mutant mice.
Topics: Action Potentials; Animals; Benzoates; Bicuculline; Dose-Response Relationship, Drug; Drug Interacti | 2003 |
Modulation of epileptiform burst frequency by the metabotropic glutamate receptor subtype mGluR3.
Topics: Animals; Anticonvulsants; Calcium; Cerebrospinal Fluid; Cyclopropanes; Dentate Gyrus; Dipeptides; El | 2003 |
Effects of taurine and glycine on epileptiform activity induced by removal of Mg2+ in combined rat entorhinal cortex-hippocampal slices.
Topics: Action Potentials; Animals; Entorhinal Cortex; Epilepsy; Female; Glycine; Hippocampus; In Vitro Tech | 2003 |
Evidence that phospholipase D activation prevents group I mGluR-induced persistent prolongation of epileptiform bursts.
Topics: Animals; Cyclopropanes; Cysteine; Epilepsy; GABA Antagonists; GABA-A Receptor Antagonists; Glycine; | 2004 |
In vitro 1H NMR spectroscopy shows an increase in N-acetylaspartylglutamate and glutamine content in the hippocampus of amygdaloid-kindled rats.
Topics: Amino Acids; Amygdala; Animals; Creatine; Dipeptides; Disease Models, Animal; Energy Metabolism; Epi | 2005 |
Seizures induced by microperfusion of glutamate and glycine in the hippocampus of rats pretreated with latrunculin A.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Dizocilpine Maleate; Drug Interactions; Epilepsy; | 2005 |
Bench meets bedside: a 10-year-old girl and amino acid residue glycine 75 of the facilitative glucose transporter GLUT1.
Topics: 3-O-Methylglucose; Amino Acid Sequence; Child; Epilepsy; Female; Glycine; Humans; Models, Molecular; | 2005 |
GAMT deficiency: features, treatment, and outcome in an inborn error of creatine synthesis.
Topics: Adolescent; Adult; Child; Creatine; Epilepsy; Female; Glycine; Guanidinoacetate N-Methyltransferase; | 2006 |
omega-Conotoxin MVIIA inhibits amygdaloid kindled seizures in Sprague-Dawley rats.
Topics: Amygdala; Animals; Anticonvulsants; Brain Stem; Calcium Channel Blockers; Calcium Channels, N-Type; | 2007 |
Activity-dependent induction and maintenance of epileptiform activity produced by group I metabotropic glutamate receptors in the rat hippocampal slice.
Topics: Action Potentials; Animals; Catechols; Electrophysiology; Enzyme Inhibitors; Epilepsy; Excitatory Am | 2008 |
Is epilepsy a disorder of inhibition or excitation?
Topics: Animals; Cats; Central Nervous System; Convulsants; Epilepsy; gamma-Aminobutyric Acid; Glycine; Huma | 1983 |
Convulsant drugs: mechanisms of action.
Topics: Amino Acids; Barbiturates; Biological Transport, Active; Brain; Cholinesterase Inhibitors; Convulsan | 1980 |
N,N-dimethylglycine for epilepsy.
Topics: Adult; Epilepsy; Glycine; Humans; Male; Sarcosine | 1982 |
N,N-dimethylglycine for epilepsy.
Topics: Epilepsy; Glycine; Humans; Mutagens; Sarcosine | 1983 |
Failure of N,N-dimethylglycine in epilepsy.
Topics: Adolescent; Adult; Child; Child, Preschool; Double-Blind Method; Epilepsy; Female; Glycine; Humans; | 1983 |
N,N-dimethylglycine shows no anticonvulsant potential.
Topics: Animals; Epilepsy; Glycine; Mice; Sarcosine | 1984 |
N,N-dimethylglycine, betaine, and seizures.
Topics: Betaine; Epilepsy; Glycine; Humans; Sarcosine | 1984 |
Subcellular distribution of neuroactive amino acids in brains of genetically epileptic rats.
Topics: Alanine; Amino Acids; Animals; Brain Chemistry; Epilepsy; gamma-Aminobutyric Acid; Glutamates; Gluta | 1984 |
Plasma amino acids in 3/sec spike-wave epilepsy.
Topics: Adolescent; Adult; Alanine; Amino Acids; Aspartic Acid; Child; Child, Preschool; Epilepsy; Female; G | 1980 |
[Inhibition by dipropyl acetate and its structural analogs of the glycine synthase system in liver and brain mitochondria].
Topics: Amino Acid Oxidoreductases; Animals; Anticonvulsants; Brain; Carrier Proteins; Epilepsy; Glycine; Ma | 1982 |
Effect of epileptogenic agents on the incorporation of 3H-glycine into proteins in the cat's cerebral cortex.
Topics: Acoustic Stimulation; Aminopyridines; Animals; Cats; Cerebral Cortex; Convulsants; Cycloheximide; Ep | 1982 |
The action of glycine on rat epileptic foci.
Topics: Action Potentials; Animals; Cerebral Cortex; Epilepsy; gamma-Aminobutyric Acid; Glycine; Male; Rats | 1981 |
The functional role of metabotropic glutamate receptors in epileptiform activity induced by 4-aminopyridine in the rat amygdala slice.
Topics: 4-Aminopyridine; Amygdala; Animals; Benzoates; Epilepsy; Excitatory Amino Acid Antagonists; Glycine; | 1995 |
Anticonvulsant activity of antagonists and partial agonists for the NMDA receptor-associated glycine site in the kindling model of epilepsy.
Topics: Animals; Anticonvulsants; Cycloserine; Differential Threshold; Epilepsy; Female; Glycine; Kindling, | 1994 |
Plasma amino acid alterations in idiopathic generalized epilepsy: an investigation in probands and their first-degree relatives.
Topics: Adult; Amino Acids; Aspartic Acid; Epilepsy; Family; Female; Glutamates; Glycine; Humans; Male; Taur | 1994 |
Amino acid levels in the cerebrospinal fluid of newly diagnosed epileptic patients: effect of vigabatrin and carbamazepine monotherapies.
Topics: Adolescent; Adult; Amino Acids; Aminocaproates; Carbamazepine; Carnosine; Epilepsy; Female; gamma-Am | 1993 |
Co-variation of free amino acids in human epileptogenic cortex.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amino Acids; Astrocytoma; Cerebral Cortex; Child; Child, | 1993 |
[Non-ketotic hyperglycinemia. Transient neonatal form].
Topics: Epilepsy; Frontal Lobe; Glycine; Humans; Infant, Newborn; Male; Tomography, X-Ray Computed; Ultrason | 1996 |
Prolonged anticonvulsant action of glutamate metabotropic receptor agonists in inferior colliculus of genetically epilepsy-prone rats.
Topics: Animals; Behavior, Animal; Cycloleucine; Dose-Response Relationship, Drug; Epilepsy; Female; Glycine | 1997 |
[Evaluation of the effect of long term valproic acid treatment on plasma levels of carnitine, ammonia and amino acids related to the urea cycle in pediatric epileptic patients].
Topics: Adolescent; Amino Acids; Ammonia; Anticonvulsants; Carnitine; Child; Child, Preschool; Epilepsy; Glu | 1997 |
Pharmacokinetic analysis and antiepileptic activity of two new isomers of N-valproyl glycinamide.
Topics: Animals; Anticonvulsants; Dogs; Drug Evaluation, Preclinical; Epilepsy; Glycine; Half-Life; Injectio | 1997 |
Requirement of protein synthesis for group I mGluR-mediated induction of epileptiform discharges.
Topics: Action Potentials; Animals; Anisomycin; Brain Chemistry; Convulsants; Epilepsy; Excitatory Amino Aci | 1998 |
Prolonged activation of the N-methyl-D-aspartate receptor-Ca2+ transduction pathway causes spontaneous recurrent epileptiform discharges in hippocampal neurons in culture.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Benzoates; Calcium; Cells, Cultured; Dizocil | 1998 |
Differential effects of metabotropic glutamate receptor antagonists on bursting activity in the amygdala.
Topics: Amygdala; Animals; Benzoates; Cycloleucine; Electrophysiology; Epilepsy; Excitatory Amino Acid Antag | 1999 |
N-methyl-D-aspartate receptor binding is altered and seizure potential reduced in pregnant rats.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Conv | 1999 |
Quantitative differences in the effects of de novo produced and exogenous kynurenic acid in rat brain slices.
Topics: Animals; Buffers; Entorhinal Cortex; Epilepsy; Evoked Potentials; Excitatory Amino Acid Antagonists; | 1999 |
Ketone bodies do not directly alter excitatory or inhibitory hippocampal synaptic transmission.
Topics: 3-Hydroxybutyric Acid; 4-Aminopyridine; Acetoacetates; Animals; Cells, Cultured; Diet; Entorhinal Co | 2000 |
Epileptogenesis up-regulates metabotropic glutamate receptor activation of sodium-calcium exchange current in the amygdala.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amygdala; Animals; Calcium; Dose- | 2000 |
Mental retardation and behavioral problems as presenting signs of a creatine synthesis defect.
Topics: Aspartic Acid; Body Fluids; Brain Diseases, Metabolic; Child, Preschool; Creatine; Diagnosis, Differ | 2000 |
Re: Mazarati et al. "...clinically available [antiepileptic drug] with a moderate affinity for the glycine site of the N-methyl-D-aspartate (NMDA) receptor".
Topics: Anticonvulsants; Epilepsy; Felbamate; Glycine; Humans; N-Methylaspartate; Phenylcarbamates; Propylen | 2000 |
Generation and propagation of 4-AP-induced epileptiform activity in neonatal intact limbic structures in vitro.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potential | 2000 |
Effect of extracellular long-time microperfusion of high concentrations of glutamate and glycine on picrotoxin seizure thresholds in the hippocampus of freely moving rats.
Topics: Animals; Epilepsy; Excitatory Amino Acid Antagonists; Extracellular Space; GABA Antagonists; Glutami | 2001 |
Seizure-like activity in the disinhibited CA1 minislice of adult guinea-pigs.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Age Factors; Animals; Bicuculline; Epilepsy | 2001 |
Preclinical evaluation of CHF3381 as a novel antiepileptic agent.
Topics: Animals; Anticonvulsants; Dizocilpine Maleate; Drug Evaluation, Preclinical; Epilepsy; Excitatory Am | 2001 |
Attenuation of seizures induced by homocysteic acid in immature rats by metabotropic glutamate group II and group III receptor agonists.
Topics: Animals; Animals, Newborn; Anticonvulsants; Brain; Cyclobutanes; Cyclopropanes; Dose-Response Relati | 2001 |
Group I metabotropic glutamate receptors elicit epileptiform discharges in the hippocampus through PLCbeta1 signaling.
Topics: Animals; Biological Clocks; Cell Membrane; Crosses, Genetic; Enzyme Inhibitors; Epilepsy; Excitatory | 2001 |
Anticonvulsant profile of valrocemide (TV1901): a new antiepileptic drug.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Dose-Respo | 2001 |
[Features of neurotransmitter pool in cerebrospinal fluid of patients with epilepsy].
Topics: Adult; Aspartic Acid; Brain; Epilepsy; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Huma | 2001 |
Differential roles for mGluR1 and mGluR5 in the persistent prolongation of epileptiform bursts.
Topics: Animals; Benzoates; Convulsants; Dose-Response Relationship, Drug; Epilepsy; Excitatory Amino Acid A | 2002 |
Dipropylacetate (valproate) and glycine metabolism.
Topics: Epilepsy; Glycine; Humans; Infant; Valerates; Valproic Acid | 1977 |
Anticonvulsant action of a 1,5-benzodiazepine, clobazam, in reflex epilepsy.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Benzodiazepinones; Disease Models, Animal; Drug Eval | 1978 |
Sodium valproate, pregnancy, and neonatal hyperglycinaemia.
Topics: Adult; Epilepsy; Female; Glycine; Humans; Infant, Newborn; Infant, Newborn, Diseases; Pregnancy; Pre | 1979 |
Dipropylacetate and hyperglycinemia.
Topics: Adolescent; Child; Epilepsy; Glycine; Humans; Valproic Acid | 1979 |
Biochemical observations following administration of taurine to patients with epilepsy.
Topics: Adolescent; Adult; Alanine; Anticonvulsants; Aspartic Acid; Cerebral Cortex; Child; Child, Preschool | 1975 |
Four models for studying cerebral lesions secondary to epileptic seizures.
Topics: Animals; Astrocytes; Bicuculline; Blood Gas Analysis; Blood Glucose; Blood Pressure; Body Temperatur | 1975 |
Photically induced epilepsy in Papio papio as a model for drug studies.
Topics: Acetylcholine; Animals; Carbamazepine; Clonazepam; Diazepam; Disease Models, Animal; Dopamine; Dose- | 1975 |
Autoradiography and interaction of modulators of NMDA receptor activation.
Topics: Amino Acids; Animals; Anticonvulsants; Autoradiography; Binding, Competitive; Brain; Brain Mapping; | 1992 |
Guanidino compound levels in the serum of healthy adults and epileptic patients.
Topics: Adult; Arginine; Creatinine; Epilepsy; Female; Glycine; Guanidines; Homoarginine; Humans; Male; Phen | 1991 |
[3H]MK-801 binding to forebrain of E1 (epileptic) and non-epileptic strains of mice.
Topics: Animals; Brain; Dizocilpine Maleate; Epilepsy; Glutamates; Glycine; Kinetics; Mice; Radioligand Assa | 1991 |
The quaking mouse: an epileptic mutant with alterations affecting the modulatory mechanisms of the NMDA receptor complex.
Topics: Animals; Brain; Cell Membrane; Epilepsy; Glutamates; Glycine; Kinetics; Male; Mice; Mice, Inbred C57 | 1991 |
High-performance liquid chromatographic determination of selected amino acids in rat brain by precolumn derivatization with phenylisothiocyanate.
Topics: Amino Acids; Animals; Aspartic Acid; Brain; Brain Chemistry; Chromatography, High Pressure Liquid; D | 1990 |
Dimethylglycine and reduction of mortality in penicillin-induced seizures.
Topics: Animals; Anticonvulsants; Epilepsy; Female; Glycine; Penicillin G; Rats; Rats, Inbred Strains; Sarco | 1985 |
Influence of pharmacological manipulation of inhibitory and excitatory neurotransmitter systems on seizure behavior in the Mongolian gerbil.
Topics: Adrenergic alpha-Agonists; Air; Amino Acids; Animals; Anticonvulsants; Atropine; Carbidopa; Disease | 1985 |
Putative amino acid transmitters in lumbar cerebrospinal fluid of patients with histologically verified Alzheimer's dementia.
Topics: Adult; Aged; Alzheimer Disease; Amino Acids; Aspartic Acid; Dementia; Epilepsy; Female; Glutamates; | 1985 |
Redistribution of transmitter amino acids in rat hippocampus and cerebellum during seizures induced by L-allylglycine and bicuculline: an immunocytochemical study with antisera against conjugated GABA, glutamate and aspartate.
Topics: Allylglycine; Animals; Aspartic Acid; Bicuculline; Cerebellum; Epilepsy; Evoked Potentials; gamma-Am | 1987 |
[Non-ketotic hyperglycinemia. Study of a case].
Topics: Amino Acid Metabolism, Inborn Errors; Brain; Brain Chemistry; Electroencephalography; Epilepsy; Fema | 1987 |
Bicuculline- and allylglycine-induced epilepsy in developing rats.
Topics: Allylglycine; Animals; Behavior, Animal; Bicuculline; Brain; Electroencephalography; Epilepsy; Femal | 1985 |
Amino acid content of epileptogenic human brain: focal versus surrounding regions.
Topics: Adolescent; Adult; Alanine; Amino Acids; Aminobutyrates; Aspartic Acid; Brain; Cerebral Cortex; Chil | 1972 |
Close correlation between changing content of specific amino acids in epileptogenic cortex of cats, and severity of epilepsy.
Topics: Alanine; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Cats; Cerebral Cortex; Cobalt; Electro | 1972 |
Neuronal loss and gliosis in the hippocampus following repetitive epileptic seizures induced in adolescent baboons by allylglycine.
Topics: Animals; Cerebellum; Cerebral Cortex; Disease Models, Animal; Electroencephalography; Epilepsy; Glyc | 1972 |
Familial hyperprolinemia without mental retardation and hereditary nephropathy.
Topics: Amino Acid Metabolism, Inborn Errors; Epilepsy; Female; Glycine; Humans; Infant; Intellectual Disabi | 1972 |
Amino acid abnormality in Sjögren-Larsson syndrome.
Topics: Adolescent; Amino Acid Metabolism, Inborn Errors; Dental Enamel Hypoplasia; Epilepsy; Ethylamines; G | 1973 |