Page last updated: 2024-10-18

glycine and Atherosclerosis

glycine has been researched along with Atherosclerosis in 18 studies

Atherosclerosis: A thickening and loss of elasticity of the walls of ARTERIES that occurs with formation of ATHEROSCLEROTIC PLAQUES within the ARTERIAL INTIMA.

Research Excerpts

ExcerptRelevanceReference
" The hyperhomocysteinemia, suppressed immunity, and altered oxidative metabolism observed in atherosclerosis and dementia are attributed to deficiency of adenosyl methionine which results from increased polyamine biosynthesis by pathogenic microbes that are demonstrated in atherosclerotic plaques and cerebral plaques."9.05Environmental Pollution, Oxidative Stress and Thioretinaco Ozonide: Effects of Glyphosate, Fluoride and Electromagnetic Fields on Mitochondrial Dysfunction in Carcinogenesis, Atherogenesis and Aging. ( McCully, KS, 2020)
"Lower circulating levels of glycine are consistently reported in association with cardiovascular disease (CVD), but the causative role and therapeutic potential of glycine in atherosclerosis, the underlying cause of most CVDs, remain to be established."8.12Induction of glutathione biosynthesis by glycine-based treatment mitigates atherosclerosis. ( Aviram, M; Chen, YE; Das, S; Delgadillo, L; Finney, AC; Garcia-Barrio, MT; Ghrayeb, A; Gottlieb, E; Hayek, T; Kevil, CG; Liu, Y; Mor, I; Pattillo, CB; Rajanayake, KK; Rashdan, NA; Rom, O; Shukha, Y; Sun, D; Wang, L; Weissman, N; Wen, B; Yurdagul, A; Zhang, J; Zhao, Y, 2022)
" The hyperhomocysteinemia, suppressed immunity, and altered oxidative metabolism observed in atherosclerosis and dementia are attributed to deficiency of adenosyl methionine which results from increased polyamine biosynthesis by pathogenic microbes that are demonstrated in atherosclerotic plaques and cerebral plaques."5.05Environmental Pollution, Oxidative Stress and Thioretinaco Ozonide: Effects of Glyphosate, Fluoride and Electromagnetic Fields on Mitochondrial Dysfunction in Carcinogenesis, Atherogenesis and Aging. ( McCully, KS, 2020)
"Lower circulating levels of glycine are consistently reported in association with cardiovascular disease (CVD), but the causative role and therapeutic potential of glycine in atherosclerosis, the underlying cause of most CVDs, remain to be established."4.12Induction of glutathione biosynthesis by glycine-based treatment mitigates atherosclerosis. ( Aviram, M; Chen, YE; Das, S; Delgadillo, L; Finney, AC; Garcia-Barrio, MT; Ghrayeb, A; Gottlieb, E; Hayek, T; Kevil, CG; Liu, Y; Mor, I; Pattillo, CB; Rajanayake, KK; Rashdan, NA; Rom, O; Shukha, Y; Sun, D; Wang, L; Weissman, N; Wen, B; Yurdagul, A; Zhang, J; Zhao, Y, 2022)
"The liver expression levels of APOA1bp were associated with lower cIMT and leukocyte counts, a better plasma lipid profile and higher circulating levels of metabolites associated with lower risk of atherosclerosis (glycine, histidine and asparagine)."3.96The APOA1bp-SREBF-NOTCH axis is associated with reduced atherosclerosis risk in morbidly obese patients. ( Barton, RH; Burcelin, R; Dumas, ME; Federici, M; Fernández-Real, JM; Hoyles, L; Mayneris-Perxachs, J; Puig, J, 2020)
"To investigate antiatherosclerosis effect of atorvastatin (ATV) in a rat atherosclerosis model, and to explore roles of nitric oxide and hydrogen sulfide (H2S) in this event."3.81The roles of nitric oxide and hydrogen sulfide in the anti-atherosclerotic effect of atorvastatin. ( Cai, Y; Fan, Z; Feng, J; Jiang, F; Li, J; Liu, X; Ma, D; Zha, K; Zheng, S, 2015)
"Atherosclerosis is a multifactorial and progressive disease commonly correlated with a high fat diet."1.40Serum metabonomic analysis of apoE(-/-) mice reveals progression axes for atherosclerosis based on NMR spectroscopy. ( Guo, J; Li, J; Li, X; Liu, Y; Wang, L; Wu, T; Yang, Y; Yuan, F; Zhang, Q; Zheng, L, 2014)

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19902 (11.11)18.7374
1990's0 (0.00)18.2507
2000's4 (22.22)29.6817
2010's7 (38.89)24.3611
2020's5 (27.78)2.80

Authors

AuthorsStudies
Millar, CL1
Anto, L1
Garcia, C1
Kim, MB1
Jain, A1
Provatas, AA1
Clark, RB1
Lee, JY1
Nichols, FC1
Blesso, CN1
Rom, O1
Liu, Y3
Finney, AC1
Ghrayeb, A1
Zhao, Y1
Shukha, Y1
Wang, L3
Rajanayake, KK1
Das, S1
Rashdan, NA1
Weissman, N1
Delgadillo, L1
Wen, B1
Garcia-Barrio, MT1
Aviram, M1
Kevil, CG1
Yurdagul, A1
Pattillo, CB1
Zhang, J1
Sun, D1
Hayek, T1
Gottlieb, E1
Mor, I1
Chen, YE1
Zhang, X1
Zhang, Y2
Wang, P1
Zhang, SY1
Dong, Y1
Zeng, G1
Yan, Y1
Sun, L1
Wu, Q1
Liu, H2
Liu, B1
Kong, W1
Wang, X2
Jiang, C1
Mayneris-Perxachs, J1
Puig, J1
Burcelin, R1
Dumas, ME1
Barton, RH1
Hoyles, L1
Federici, M1
Fernández-Real, JM1
McCully, KS1
Zagefka, H1
Huynh, HP1
Senger, AR1
Derington, CG1
Colantonio, LD1
Herrick, JS1
Cook, J1
King, JB1
Rosenson, RS1
Poudel, B1
Monda, KL1
Navar, AM1
Mues, KE1
Stevens, VW1
Nelson, RE1
Vanneman, ME1
Muntner, P1
Bress, AP1
Ma, B1
Ren, G1
Xu, J1
Yin, C1
Shi, Y1
Rahsepar, AA1
Bluemke, DA1
Habibi, M1
Liu, K1
Kawel-Boehm, N1
Ambale-Venkatesh, B1
Fernandes, VRS1
Rosen, BD1
Lima, JAC1
Carr, JC1
Freitag, TM1
Chen-Sankey, JC1
Duarte, DA1
Ramsey, MW1
Choi, K1
Winkler-Heil, R1
Hussain, M1
Hofmann, W1
Nicotera, AG1
Dicanio, D1
Pironti, E1
Bonsignore, M1
Cafeo, A1
Efthymiou, S1
Mondello, P1
Salpietro, V1
Houlden, H1
Di Rosa, G1
Hayes-Ryan, D1
O'Donoghue, K1
McCarthy, C1
Totorika, A1
Meaney, S1
Pang, RD1
Dormanesh, A1
Hoang, Y1
Chu, M1
Allem, JP1
Girón-Ortega, JA1
Márquez-Coello, M1
Gutiérrez-Saborido, D1
Arizcorreta, A1
Cuesta-Sancho, S1
Girón-González, JA1
Dovrat, G1
Pevzner, S1
Berthon, C1
Lerner, A1
Maimon, E1
Vainer, R1
Karpasas, M1
Ben-Elyiahu, Y1
Moisy, P1
Bettelheim, A1
Zilbermann, I1
Vanden Broeck, SMP1
Nelson, DJ1
Collado, A1
Falivene, L1
Cavallo, L1
Cordes, DB1
Slawin, AMZ1
Van Hecke, K1
Nahra, F1
Cazin, CSJ1
Nolan, SP1
Kranidiotis-Hisatomi, N1
Yi, H1
Oestreich, M1
Kwiezinski, C1
Weller, C1
van Pinxteren, D1
Brüggemann, M1
Mertes, S1
Stratmann, F1
Herrmann, H1
Treggiari, D1
Tridello, G1
Menin, L1
Borruso, A1
Pintani, E1
Iansa, P1
Cipolli, M1
Melotti, P1
Ren, L1
Liu, L3
Shu, X1
Lin, W1
Yang, P1
Chen, J1
Teo, KL1
Xiao, F1
Wang, H1
Yao, T1
Zhao, X2
Yang, X2
Yu, DYW1
Rogach, AL1
Bordet, A1
Leitner, W1
Gao, S1
Xia, F1
Li, B2
Abdul Razak, IB1
Lu, K1
Brown, DE1
Wang, R1
Cheng, Y1
Ni, S1
Qu, H1
Xing, H1
Xu, Z1
Zhu, X1
Yuan, M1
Yu, J1
Li, Y1
Yang, L1
Cao, L1
Zhang, S1
Zhao, D1
Yan, T1
Yang, G1
Lin, Z1
Luo, M1
Ye, N1
Lee, SW1
Carnicelli, J1
Getya, D1
Gitsov, I1
Phillips, KS1
Ren, D1
Grützmacher, PG1
Suarez, S1
Tolosa, A1
Gachot, C1
Song, G1
Wang, B1
Presser, V1
Mücklich, F1
Anasori, B1
Rosenkranz, A1
Demireva, M1
Armentrout, PB1
Feng, D1
Cao, K1
He, ZZ1
Knibbs, LD1
Jalaludin, B1
Leskinen, A1
Roponen, M1
Komppula, M1
Jalava, P1
Guo, PY1
Xu, SL1
Yang, BY1
Hu, L1
Zeng, XW1
Chen, G1
Yu, HY1
Lin, L1
Dong, G1
Machulkin, AE1
Shafikov, RR1
Uspenskaya, AA1
Petrov, SA1
Ber, AP1
Skvortsov, DA1
Nimenko, EA1
Zyk, NU1
Smirnova, GB1
Pokrovsky, VS1
Abakumov, MA1
Saltykova, IV1
Akhmirov, RT1
Garanina, AS1
Polshakov, VI1
Saveliev, OY1
Ivanenkov, YA1
Aladinskaya, AV1
Finko, AV1
Yamansarov, EU1
Krasnovskaya, OO1
Erofeev, AS1
Gorelkin, PV1
Dontsova, OA1
Beloglazkina, EK1
Zyk, NV1
Khazanova, ES1
Majouga, AG1
Zheng, YK1
Su, BJ1
Wang, YQ1
Wang, HS1
Liao, HB1
Liang, D1
Shataer, D1
Li, J4
Duan, XM1
Xin, XL1
Aisa, HA1
Allu, SR1
Ravotto, L1
Troxler, T1
Vinogradov, SA1
Cheruku, RR1
Tracy, EC1
Tabaczynski, W1
Missert, JR1
Baumann, H1
Pandey, RK1
Rohde, JM1
Karavadhi, S1
Pragani, R1
Fang, Y1
Zhang, W1
McIver, A1
Zheng, H1
Liu, Q1
Davis, MI1
Urban, DJ1
Lee, TD1
Cheff, DM1
Hollingshead, M1
Henderson, MJ1
Martinez, NJ1
Brimacombe, KR1
Yasgar, A1
Zhao, W1
Klumpp-Thomas, C1
Michael, S1
Covey, J1
Moore, WJ1
Stott, GM1
Li, Z1
Simeonov, A1
Jadhav, A1
Frye, S1
Hall, MD1
Shen, M1
Patnaik, S1
Boxer, MB1
Zhang, H2
Cheng, C1
Huang, B1
Chen, R1
Huang, Y1
Chen, H1
Pei, W1
Katahara, S1
Sugiyama, Y1
Yamane, M1
Komiya, Y1
Sato, T1
Chida, N1
Ma, N1
Yang, Y2
Liu, X2
Kong, X1
Li, S1
Qin, Z1
Jiao, Z1
Hitzel, J1
Lee, E1
Bibli, SI1
Li, X2
Zukunft, S1
Pflüger, B1
Hu, J1
Schürmann, C1
Vasconez, AE1
Oo, JA1
Kratzer, A1
Kumar, S1
Rezende, F1
Josipovic, I1
Thomas, D1
Giral, H1
Schreiber, Y1
Geisslinger, G1
Fork, C1
Sigala, F1
Romanoski, CE1
Kroll, J1
Jo, H1
Landmesser, U1
Lusis, AJ1
Namgaladze, D1
Fleming, I1
Leisegang, MS1
Zhu, J1
Brandes, RP1
Ma, D1
Zheng, S2
Zha, K1
Feng, J1
Cai, Y1
Jiang, F1
Fan, Z1
Zheng, L1
Wu, T1
Zhang, Q1
Yuan, F1
Guo, J1
Wang, Y1
Jin, H1
Wei, H1
Li, W1
Bu, D1
Tang, X1
Ren, Y1
Tang, C1
Du, J1
McCarty, MF1
Barroso-Aranda, J1
Contreras, F1
Zhou, K1
Gao, Q1
Pan, S1
Li, P1
Suo, K1
Simoncini, T1
Wang, T1
Fu, X1
Lees, HJ1
Swann, JR1
Wilson, ID1
Nicholson, JK1
Holmes, E1
MORRISON, LM1
BEAUMONT, JL1
SCHWARTZ, D1
Orbe, J1
Beloqui, O1
Rodriguez, JA1
Belzunce, MS1
Roncal, C1
Páramo, JA1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Effects of Glycine on Atherosclerosis and Metabolic Syndrome-related Parameters: A Clinical and Ex-vivo Study.[NCT03850314]Phase 2/Phase 350 participants (Anticipated)Interventional2019-03-31Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for glycine and Atherosclerosis

ArticleYear
Environmental Pollution, Oxidative Stress and Thioretinaco Ozonide: Effects of Glyphosate, Fluoride and Electromagnetic Fields on Mitochondrial Dysfunction in Carcinogenesis, Atherogenesis and Aging.
    Annals of clinical and laboratory science, 2020, Volume: 50, Issue:3

    Topics: Aging; Animals; Atherosclerosis; Carcinogenesis; Electromagnetic Fields; Environmental Pollution; Fl

2020
Hippurate: the natural history of a mammalian-microbial cometabolite.
    Journal of proteome research, 2013, Apr-05, Volume: 12, Issue:4

    Topics: Age Factors; Animals; Atherosclerosis; Autistic Disorder; Benzoic Acid; Diabetes Mellitus; Diet; Fem

2013

Other Studies

16 other studies available for glycine and Atherosclerosis

ArticleYear
Gut microbiome-derived glycine lipids are diet-dependent modulators of hepatic injury and atherosclerosis.
    Journal of lipid research, 2022, Volume: 63, Issue:4

    Topics: Animals; Atherosclerosis; Bacteria; Bacteroidetes; Diet, High-Fat; Gastrointestinal Microbiome; Glyc

2022
Induction of glutathione biosynthesis by glycine-based treatment mitigates atherosclerosis.
    Redox biology, 2022, Volume: 52

    Topics: Animals; Apolipoproteins E; Atherosclerosis; Disease Models, Animal; Glutamate-Cysteine Ligase; Glut

2022
Adipocyte Hypoxia-Inducible Factor 2α Suppresses Atherosclerosis by Promoting Adipose Ceramide Catabolism.
    Cell metabolism, 2019, 11-05, Volume: 30, Issue:5

    Topics: Adipocytes; Adipose Tissue; Alkaline Ceramidase; Animals; Atherosclerosis; Basic Helix-Loop-Helix Tr

2019
The APOA1bp-SREBF-NOTCH axis is associated with reduced atherosclerosis risk in morbidly obese patients.
    Clinical nutrition (Edinburgh, Scotland), 2020, Volume: 39, Issue:11

    Topics: Adult; Asparagine; Atherosclerosis; Biopsy; Carotid Intima-Media Thickness; Cross-Sectional Studies;

2020
    Journal of applied social psychology, 2021, Volume: 51, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Air Pollutants; Air Pollution; Animals; Anti-Bacterial Agents; Anti-

2021
UPLC-Q-TOF/MS-based metabonomic studies on the intervention effects of aspirin eugenol ester in atherosclerosis hamsters.
    Scientific reports, 2017, 09-05, Volume: 7, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Aspirin; Atherosclerosis; Biomarkers; Citric Acid; Cricetinae; Eu

2017
Oxidized phospholipids regulate amino acid metabolism through MTHFD2 to facilitate nucleotide release in endothelial cells.
    Nature communications, 2018, 06-12, Volume: 9, Issue:1

    Topics: Amino Acids; Aminohydrolases; Animals; Aorta; Atherosclerosis; Bayes Theorem; Cardiovascular Disease

2018
The roles of nitric oxide and hydrogen sulfide in the anti-atherosclerotic effect of atorvastatin.
    Journal of cardiovascular medicine (Hagerstown, Md.), 2015, Volume: 16, Issue:1

    Topics: Alkynes; Animals; Aorta, Thoracic; Atherosclerosis; Atorvastatin; Diet, High-Fat; Glycine; Heptanoic

2015
Serum metabonomic analysis of apoE(-/-) mice reveals progression axes for atherosclerosis based on NMR spectroscopy.
    Molecular bioSystems, 2014, Volume: 10, Issue:12

    Topics: Animals; Atherosclerosis; Biomarkers; Cholesterol, HDL; Cholesterol, LDL; Choline; Diet, High-Fat; D

2014
Role of hydrogen sulfide in the development of atherosclerotic lesions in apolipoprotein E knockout mice.
    Arteriosclerosis, thrombosis, and vascular biology, 2009, Volume: 29, Issue:2

    Topics: Active Transport, Cell Nucleus; Alkynes; Animals; Aorta; Apolipoproteins E; Atherosclerosis; Body We

2009
The hyperpolarizing impact of glycine on endothelial cells may be anti-atherogenic.
    Medical hypotheses, 2009, Volume: 73, Issue:2

    Topics: Animals; Atherosclerosis; Cattle; Endothelium, Vascular; Glycine; Rats

2009
17β-estradiol induces vasorelaxation by stimulating endothelial hydrogen sulfide release.
    Molecular human reproduction, 2013, Volume: 19, Issue:3

    Topics: Acetylcholine; Alkynes; Animals; Aorta; Apolipoproteins E; Atherosclerosis; Cyclic GMP-Dependent Pro

2013
Results of betaine treatment of atherosclerosis.
    The American journal of digestive diseases, 1952, Volume: 19, Issue:12

    Topics: Arteriosclerosis; Atherosclerosis; Betaine; Coronary Disease; Fabaceae; Glycine

1952
[BLOOD CHOLESTEROL AND TRIGLYCERIDES IN 2 OCCUPATIONAL GROUPS. FIRST RESULTS OF AN EPIDEMIOLOGIC INVESTIGATION ON THE FACTORS OF ATHEROSCLEROSIS].
    Revue de l'atherosclerose, 1964, Volume: 6

    Topics: Adolescent; Aging; Arteriosclerosis; Atherosclerosis; Blood; Blood Pressure; Body Weight; Cholestero

1964
Protective effect of the G-765C COX-2 polymorphism on subclinical atherosclerosis and inflammatory markers in asymptomatic subjects with cardiovascular risk factors.
    Clinica chimica acta; international journal of clinical chemistry, 2006, Volume: 368, Issue:1-2

    Topics: Atherosclerosis; Biomarkers; Cholesterol; Cyclooxygenase 2; Cysteine; Female; Gene Expression Regula

2006
A bumpy road to breakthroughs. The news: it's hard to beat today's cardiac treatments.
    Heart advisor, 2006, Volume: 9, Issue:2

    Topics: Animals; Atherosclerosis; Coronary Thrombosis; Diabetes Mellitus, Type 2; Ethics, Clinical; Glycine;

2006