glycine and Anoxemia studies

Research Excerpts

Excerpt	Relevance	Reference
"Roxadustat (FG-4592), an oral hypoxia-inducible factor prolyl hydroxylase inhibitor that stimulates erythropoiesis, was evaluated in a phase 1b study in patients with end-stage renal disease with anemia on hemodialysis."	9.34	Oral Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor Roxadustat (FG-4592) for Treatment of Anemia in Chronic Kidney Disease: A Placebo-Controlled Study of Pharmacokinetic and Pharmacodynamic Profiles in Hemodialysis Patients. ( Chou, J; Hemmerich, S; Neff, TB; Provenzano, R; Tumlin, J; Yu, KP; Zabaneh, R, 2020)
"This study assessed the preventive effects of arginine (ARG) and guanidinoacetic acid (GAA) on the incidence of pulmonary hypertension syndrome (PHS) in broiler chickens."	9.27	Pulmonary hypertensive response of broiler chickens to arginine and guanidinoacetic acid under high-altitude hypoxia. ( Ahmadipour, B; Khajali, F; Sharifi, M, 2018)
"Chronic Cyclosporine-A treatment is associated with serious side effects, including kidney toxicity and anemia."	8.12	Daprodustat prevents cyclosporine-A-mediated anemia and peritubular capillary loss. ( Balcerek, B; Brinkmann, L; Fähling, M; Kulow, VA; Labes, R; Mathia, S; Persson, PB; Roegner, K; Rosenberger, C, 2022)
"5% oxygen incubation in a hypoxia chamber or by exposure to the prolyl hydroxylase inhibitor FG-4592, which prevents hypoxia-inducible factor-1 alpha degradation."	7.88	Hypoxia and the Prolyl Hydroxylase Inhibitor FG-4592 Protect Corneal Endothelial Cells From Mechanical and Perioperative Surgical Stress. ( Bhadange, Y; Bonanno, JA; Kim, ET; Lautert, J; Lawando, E; Li, S; Price, FW; Price, MO; Soper, MC, 2018)
" In previous study, we linked the anti-inflammatory amino acid glycine to nitronyl nitroxide and developed a novel glycine-nitronyl nitroxide (GNN) conjugate, which showed a synergetic protection against renal ischemia/reperfusion injury."	7.85	Glycine-nitronyl nitroxide conjugate protects human umbilical vein endothelial cells against hypoxia/reoxygenation injury via multiple mechanisms and ameliorates hind limb ischemia/reperfusion injury in rats. ( Bi, W; Bi, Y; Chi, K; Gao, X; Li, X; Liu, Y; Yuan, T, 2017)
"HI and hypoxia were associated with a significant increase in the ratio of acyl-CoA:CoA, which was prevented by treatment with carnitine."	7.73	Carnitine treatment inhibits increases in cerebral carnitine esters and glutamate detected by mass spectrometry after hypoxia-ischemia in newborn rats. ( Chace, DH; Kohli, R; Wainwright, MS; Whitington, PF, 2006)
"This study tested the hypothesis that cerebral hypoxia results in nitric oxide (NO)-mediated modification of the glycine-binding site of the N-methyl-D-aspartate (NMDA) receptor."	7.72	Nitric oxide-mediated modification of the glycine binding site of the NMDA receptor during hypoxia in the cerebral cortex of the newborn piglet. ( Fritz, KI; Haider, SH; Mishra, OP; Papadopoulos, MD; Parikh, N; Sorrentino, DF, 2004)
"The release of preloaded [3H]glycine from hippocampal slices from 7-day-old and 3-month-old (adult) mice was studied in different cell-damaging conditions, including hypoxia, hypoglycemia, ischemia, oxidative stress and the presence of free radicals and metabolic poisons, using a superfusion system."	7.71	Characteristics of hippocampal glycine release in cell-damaging conditions in the adult and developing mouse. ( Oja, SS; Saransaari, P, 2001)
" Isocaloric and isonitrogenous supplementation with glycine did not influence hypoxia-induced fetal growth restriction."	7.70	Dietary L-arginine prevents fetal growth restriction in rats. ( Harvey-Wilkes, KB; Hassoun, PM; Vosatka, RJ, 1998)
"The present study was designed to investigate the mechanism of NMDA receptor activation as a function of brain maturation by studying the development of the glycine binding site of the NMDA receptor and its modification by in-utero hypoxia in the guinea pig fetus brain during gestation."	7.69	Modification of the glycine (co-activator) binding site of the N-methyl-D-aspartate receptor in the guinea pig fetus brain during development following hypoxia. ( Delivoria-Papadopoulos, M; Kubin, J; Mishra, OP; Razdan, B, 1996)
"The neuroprotective potential of an antagonist (7-chlorokynurenic acid (7-CIKYNA)) and a low efficacy partial agonist (HA-966) for the glycine modulatory site on the N-methyl-D-aspartate (NMDA) receptor complex has been examined using a neuronal cell culture/hypoxia model of neurodegeneration."	7.68	The effect of NMDA receptor glycine site antagonists on hypoxia-induced neurodegeneration of rat cortical cell cultures. ( Horne, AL; Kemp, JA; McKernan, RM; Priestley, T, 1990)
"Roxadustat (FG-4592), an oral hypoxia-inducible factor prolyl hydroxylase inhibitor that stimulates erythropoiesis, was evaluated in a phase 1b study in patients with end-stage renal disease with anemia on hemodialysis."	5.34	Oral Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor Roxadustat (FG-4592) for Treatment of Anemia in Chronic Kidney Disease: A Placebo-Controlled Study of Pharmacokinetic and Pharmacodynamic Profiles in Hemodialysis Patients. ( Chou, J; Hemmerich, S; Neff, TB; Provenzano, R; Tumlin, J; Yu, KP; Zabaneh, R, 2020)
"Dexrazoxane is a cardioprotective antioxidant that is clinically used to reduce the cardiotoxicity of the chemotherapeutic drug doxorubicin."	5.31	Dexrazoxane (ICRF-187) protects cardiac myocytes against hypoxia-reoxygenation damage. ( Hasinoff, BB, 2002)
"This study assessed the preventive effects of arginine (ARG) and guanidinoacetic acid (GAA) on the incidence of pulmonary hypertension syndrome (PHS) in broiler chickens."	5.27	Pulmonary hypertensive response of broiler chickens to arginine and guanidinoacetic acid under high-altitude hypoxia. ( Ahmadipour, B; Khajali, F; Sharifi, M, 2018)
"Based on his own experimental findings and data available in the literature, the author provides evidence for the expediency of using glutamate alone and in combination with glycine and methionine to correct abnormalities accompanied by hypoxia and imbalance between the rate of free radical oxidation and the degree of antioxidative defense."	4.79	[Role of glutathione containing amino acids in the correction of body's dysadaptation states]. ( Pavlov, VA, 1997)
"Chronic Cyclosporine-A treatment is associated with serious side effects, including kidney toxicity and anemia."	4.12	Daprodustat prevents cyclosporine-A-mediated anemia and peritubular capillary loss. ( Balcerek, B; Brinkmann, L; Fähling, M; Kulow, VA; Labes, R; Mathia, S; Persson, PB; Roegner, K; Rosenberger, C, 2022)
"DPC on agarose-coated plates were treated with hypoxia and the HMA dimethyloxallyl glycine (DMOG), desferrioxamine (DFO) and L-mimosine (L-MIM)."	3.88	Formation of spheroids by dental pulp cells in the presence of hypoxia and hypoxia mimetic agents. ( Agis, H; Janjić, K; Lilaj, B; Moritz, A, 2018)
"5% oxygen incubation in a hypoxia chamber or by exposure to the prolyl hydroxylase inhibitor FG-4592, which prevents hypoxia-inducible factor-1 alpha degradation."	3.88	Hypoxia and the Prolyl Hydroxylase Inhibitor FG-4592 Protect Corneal Endothelial Cells From Mechanical and Perioperative Surgical Stress. ( Bhadange, Y; Bonanno, JA; Kim, ET; Lautert, J; Lawando, E; Li, S; Price, FW; Price, MO; Soper, MC, 2018)
" In previous study, we linked the anti-inflammatory amino acid glycine to nitronyl nitroxide and developed a novel glycine-nitronyl nitroxide (GNN) conjugate, which showed a synergetic protection against renal ischemia/reperfusion injury."	3.85	Glycine-nitronyl nitroxide conjugate protects human umbilical vein endothelial cells against hypoxia/reoxygenation injury via multiple mechanisms and ameliorates hind limb ischemia/reperfusion injury in rats. ( Bi, W; Bi, Y; Chi, K; Gao, X; Li, X; Liu, Y; Yuan, T, 2017)
"The effects of hydrogen sulfide (H(2)S) and acute hypoxia are similar in isolated pulmonary arteries from various species."	3.78	Precursors and inhibitors of hydrogen sulfide synthesis affect acute hypoxic pulmonary vasoconstriction in the intact lung. ( Ahlf, SB; Dantuma, MW; Madden, JA; Olson, KR; Roerig, DL, 2012)
" Overactivation of the N-methyl-D-aspartate receptor (NMDAr) plays a central role in the pathogenesis of cerebral hypoxia-ischemia, but the role of both endogenous NMDAr co-agonists D-serine and glycine remains largely elusive."	3.78	Increased concentrations of both NMDA receptor co-agonists D-serine and glycine in global ischemia: a potential novel treatment target for perinatal asphyxia. ( Berger, R; de Barse, MM; de Koning, TJ; Fuchs, SA; Klomp, LW; Peeters-Scholte, CM; Roeleveld, MW, 2012)
" Physiological levels of hypoxia (Po(2) ∼30 mmHg) increased H(2)S levels in glomus cells, and dl-propargylglycine (PAG), a CSE inhibitor, prevented this response in a dose-dependent manner."	3.78	Endogenous H2S is required for hypoxic sensing by carotid body glomus cells. ( Fox, AP; Gadalla, MM; Kumar, GK; Makarenko, VV; Nanduri, J; Prabhakar, NR; Raghuraman, G; Snyder, SH, 2012)
"The aim of the present study was to examine whether neutrophil and its elastase activity played consequential roles in the progression of gut barrier dysfunction during acute alveolar hypoxia by using a specific neutrophil elastase inhibitor, sivelestat."	3.74	Inhibition of neutrophil elastase attenuates gut mucosal injury evoked by acute alveolar hypoxia in rabbits. ( Funakoshi, Y; Ishizaka, A; Katori, N; Kawabata, K; Kotake, Y; Morisaki, H; Nakamura, N; Suzuki, T; Takeda, J; Yajima, S; Yamada, S, 2007)
"The ventilatory response to hypoxia is influenced by the balance between inhibitory (GABA, glycine, and taurine) and excitatory (glutamate and aspartate) brainstem amino acid (AA) neurotransmitters."	3.74	Brainstem amino acid neurotransmitters and ventilatory response to hypoxia in piglets. ( Bancalari, E; Devia, CJ; Hehre, DA; Suguihara, C, 2008)
"HI and hypoxia were associated with a significant increase in the ratio of acyl-CoA:CoA, which was prevented by treatment with carnitine."	3.73	Carnitine treatment inhibits increases in cerebral carnitine esters and glutamate detected by mass spectrometry after hypoxia-ischemia in newborn rats. ( Chace, DH; Kohli, R; Wainwright, MS; Whitington, PF, 2006)
"This study tested the hypothesis that cerebral hypoxia results in nitric oxide (NO)-mediated modification of the glycine-binding site of the N-methyl-D-aspartate (NMDA) receptor."	3.72	Nitric oxide-mediated modification of the glycine binding site of the NMDA receptor during hypoxia in the cerebral cortex of the newborn piglet. ( Fritz, KI; Haider, SH; Mishra, OP; Papadopoulos, MD; Parikh, N; Sorrentino, DF, 2004)
"The release of preloaded [3H]glycine from hippocampal slices from 7-day-old and 3-month-old (adult) mice was studied in different cell-damaging conditions, including hypoxia, hypoglycemia, ischemia, oxidative stress and the presence of free radicals and metabolic poisons, using a superfusion system."	3.71	Characteristics of hippocampal glycine release in cell-damaging conditions in the adult and developing mouse. ( Oja, SS; Saransaari, P, 2001)
" Isocaloric and isonitrogenous supplementation with glycine did not influence hypoxia-induced fetal growth restriction."	3.70	Dietary L-arginine prevents fetal growth restriction in rats. ( Harvey-Wilkes, KB; Hassoun, PM; Vosatka, RJ, 1998)
"We investigated the metabolic effects of buffering agents alpha-amino-4-imidazole-propionic acid (Histidine), N, N-bis(2-hydroxyethyl)glycine (bicine), N, N-bis(2-hydroxyethyl)-2-aminoethanesulfonic acid (BES) on anaerobic energy production (via glycolysis) and conservation of key regulatory enzyme activity, and phosphofructokinase (PFK) throughout prolonged hypothermic hypoxia in porcine hearts."	3.70	Conservation of phosphorylation state of cardiac phosphofructokinase during in vitro hypothermic hypoxia. ( Churchill, TA; Kneteman, NM; Pulis, RP; Wu, BM, 2000)
"Fifteen minutes of hypoxia caused cell injury, which was completely prevented by glycine."	3.69	Glycine protection against hypoxic injury in isolated rat proximal tubules: the role of proteases. ( Bindels, RJ; Peters, SM; Tijsen, MJ; van Os, CH; Wetzels, JF, 1997)
"The present study was designed to investigate the mechanism of NMDA receptor activation as a function of brain maturation by studying the development of the glycine binding site of the NMDA receptor and its modification by in-utero hypoxia in the guinea pig fetus brain during gestation."	3.69	Modification of the glycine (co-activator) binding site of the N-methyl-D-aspartate receptor in the guinea pig fetus brain during development following hypoxia. ( Delivoria-Papadopoulos, M; Kubin, J; Mishra, OP; Razdan, B, 1996)
"We studied the effects of glycine (2 mM) on hypoxia-induced changes in phospholipids and fatty acids in isolated rat proximal tubules."	3.68	Glycine protection against hypoxic but not phospholipase A2-induced injury in rat proximal tubules. ( Burke, TJ; Gengaro, PE; Nemenoff, RA; Schrier, RW; Wang, X; Wetzels, JF, 1993)
" Two millimolar glycine potently protected tubules from lethal cell injury induced by hypoxia, antimycin A, or ouabain."	3.68	Relationships between intracellular amino acid levels and protection against injury to isolated proximal tubules. ( Davis, JA; Nissim, I; Roeser, NF; Schultz, S; Weinberg, JM, 1991)
" It was suggested that glycine may support renal function in hypoxia."	3.68	Support of hypoxic renal cell volume regulation by glycine. ( Gronow, G; Klause, N; Mályusz, M, 1990)
"The neuroprotective potential of an antagonist (7-chlorokynurenic acid (7-CIKYNA)) and a low efficacy partial agonist (HA-966) for the glycine modulatory site on the N-methyl-D-aspartate (NMDA) receptor complex has been examined using a neuronal cell culture/hypoxia model of neurodegeneration."	3.68	The effect of NMDA receptor glycine site antagonists on hypoxia-induced neurodegeneration of rat cortical cell cultures. ( Horne, AL; Kemp, JA; McKernan, RM; Priestley, T, 1990)
" This study investigated drug-drug interactions between vadadustat and oral iron supplements or iron-containing phosphate binders commonly used in Japanese clinical practice by conducting in vitro mechanistic and clinical pharmacokinetic studies."	3.01	In Vitro and Clinical Pharmacokinetic Studies of the Effects of Iron-containing Agents on Vadadustat, an Oral Hypoxia-inducible Factor-Prolyl Hydroxylase Inhibitor. ( Kawai, K; Kinoshita, S; Kokado, Y; Kondo, K; Nanjo, T, 2021)
"Glycine has been well characterized in spinal cord as an inhibitory neurotransmitter which activates a glycine-gated chloride channel (GlyR) expressed in postsynaptic membranes."	2.40	Glycine: a new anti-inflammatory immunonutrient. ( Bradford, B; Enomoto, N; Ikejema, K; Rose, ML; Rusyn, I; Schemmer, P; Seabra, V; Stacklewitz, RF; Thurman, RG; Wheeler, MD; Yin, M; Zhong, Z, 1999)
"Medial vascular calcification is a common complication of chronic kidney disease (CKD)."	1.43	Hypoxia-inducible factor-1 plays a role in phosphate-induced vascular smooth muscle cell calcification. ( Agharazii, M; Cornfield, DN; Gobeil, S; Lamalice, L; Larivière, R; Mokas, S; Richard, DE, 2016)
"Hydrogen sulfide (H2S) has recently been proposed as an endogenous mediator of cell apoptosis in various systems."	1.40	Inhibition of the endogenous CSE/H₂S system contributes to hypoxia and serum deprivation-induced apoptosis in mesenchymal stem cells. ( Guo, B; Guo, Z; Li, C; Wang, A; Xie, Y; Yang, J, 2014)
"A 78-year-old man with prostatic hypertrophy was scheduled for transurethral resection of the prostate under spinal anesthesia."	1.39	Transurethral resection of prostate syndrome: report of a case. ( Boukatta, B; El Bouazzaoui, A; Kanjaa, N; Lafrayiji, Z; Messaoudi, F; Sbai, H, 2013)
"Chemical anoxia with NaCN (1 mm) and anoxia with 95% N(2) induced a persistent inward current and a marked and robust increase in action potential-independent synaptic input."	1.34	Facilitation of spontaneous glycine release by anoxia potentiates NMDA receptor current in the hypoglossal motor neurons of the rat. ( Inoue, K; Kato, F; Kono, Y; Shigetomi, E, 2007)
"In vitro models of anoxia have revealed severe changes in neuronal functions after ischaemia but not after aglycaemia, although hypoglycaemia produced severe neuronal dysfunctions sometimes leading to coma."	1.32	Effect of ischaemia & aglycaemia on the synaptic transmission in neonatal rat spinal cord in vitro. ( Dasgupta, S; Deshpande, SB; Jha, A, 2003)
"Dexrazoxane is a cardioprotective antioxidant that is clinically used to reduce the cardiotoxicity of the chemotherapeutic drug doxorubicin."	1.31	Dexrazoxane (ICRF-187) protects cardiac myocytes against hypoxia-reoxygenation damage. ( Hasinoff, BB, 2002)
"Ten minutes of anoxia produced significant elevation of glutamate (from 0."	1.29	Effect of anoxia on excitatory amino acids in brain slices of rats and turtles: in vitro microdialysis. ( Aquila, WJ; Donnelly, DF; During, MJ; Haddad, GG; Perry, VL; Young, RS, 1993)
"Glycine sites were determined in brain sections by the binding of the selective ligand [3H]5,7-dichloro-kynurenic acid and measured by autoradiography."	1.29	Glycine site of the excitatory amino acid N-methyl-D-aspartate receptor in neonatal and adult brain. ( Barson, AJ; D'Souza, SW; McConnell, SE; Slater, P, 1993)
"During anoxia, the majority of nonlysosomal proteolysis (60%) was dependent on extracellular Ca2+."	1.29	Inhibition of nonlysosomal calcium-dependent proteolysis by glycine during anoxic injury of rat hepatocytes. ( Bronk, SF; Gores, GJ; Mellgren, RL; Nichols, JC, 1994)
"Glycine was similarly effective in reducing mTAL injury associated with hypoxic perfusion, indomethacin and amphotericin."	1.28	Effect of glycine on medullary thick ascending limb injury in perfused kidneys. ( Epstein, FH; Rosen, S; Silva, P; Spokes, K, 1991)
"The effect of anoxia and ischemia on the release of amino acid transmitters from cerebellar slices induced by veratridine or high [K+] was studied."	1.27	Effects of anoxia on the stimulated release of amino acid neurotransmitters in the cerebellum in vitro. ( Balázs, R; Bosley, TM; Gordon, RD; Woodhams, PL, 1983)
"Tetrodotoxin has no accelerative effect on cerebral aerobic glycolysis."	1.25	Effects of tetrodotoxin and anaesthetics on brain metabolism and transport during anoxia. ( Quastel, JH; Shankar, R, 1972)

Research

Studies (122)

Authors

Clinical Trials (2)

Trial Overview

Trial Outcomes

Apparent Terminal Elimination Rate Constant (Kel) of Unchanged MT-6548

Area Under the Plasma Concentration-time Curve From Time Zero to Infinity(AUC0-∞) of Unchanged MT-6548

Area Under the Plasma Concentration-time Curve From Time Zero Until the Last Quantifiable Concentration (AUC0-last) of Unchanged MT-6548

Maximum Plasma Concentration (Cmax) of Unchanged MT-6548

Mean Residence Time From Zero to Infinity (MRT0-∞) of Unchanged MT-6548

Terminal Elimination Half-life (t1/2) of Unchanged MT-6548

Time to Reach Maximum Plasma Concentration (Tmax) of Unchanged MT-6548

Changes in Serum Concentration of Inflammatory Biomarkers (TNF-alpha)

Timeframe	Studies, this research(%)	All Research%
pre-1990	18 (14.75)	18.7374
1990's	40 (32.79)	18.2507
2000's	25 (20.49)	29.6817
2010's	24 (19.67)	24.3611
2020's	15 (12.30)	2.80

Authors	Studies
Kokado, Y	1
Kawai, K	1
Nanjo, T	1
Kinoshita, S	1
Kondo, K	1
Philip, M	1
Karakka Kal, AK	1
Subhahar, MB	1
Karatt, TK	1
Mathew, B	1
Perwad, Z	1
Yasuoka, Y	1
Izumi, Y	1
Fukuyama, T	1
Omiya, H	1
Pham, TD	1
Inoue, H	1
Oshima, T	1
Yamazaki, T	1
Uematsu, T	1
Kobayashi, N	1
Shimada, Y	1
Nagaba, Y	1
Yamashita, T	1
Mukoyama, M	1
Sato, Y	1
Wall, SM	1
Sands, JM	1
Takahashi, N	1
Kawahara, K	1
Nonoguchi, H	1
Jatho, A	1
Zieseniss, A	1
Brechtel-Curth, K	1
Guo, J	1
Böker, KO	1
Salinas, G	1
Wenger, RH	1
Katschinski, DM	1
Sullivan, MK	1
Mark, PB	1
Labes, R	1
Brinkmann, L	1
Kulow, VA	1
Roegner, K	1
Mathia, S	1
Balcerek, B	1
Persson, PB	1
Rosenberger, C	1
Fähling, M	1
Tang, L	1
Wang, N	1
Wei, X	1
Huang, S	1
Wang, P	1
Zheng, Y	1
Chen, L	1
Zhang, L	1
Su, X	1
Xie, Y	2
Zhang, J	1
Li, M	1
Zhang, Q	1
Jin, G	1
Liu, F	1
Jia, S	1
Rybalchenko, N	1
Kunwar, K	1
Farmer, GE	1
Little, JT	1
Toney, GM	1
Cunningham, JT	1
Fujimaki, A	1
Ohuchi, K	1
Takizawa, S	1
Murakami, T	1
Kurita, H	1
Hozumi, I	1
Wen, X	1
Kitamura, Y	1
Wu, Z	1
Maekawa, Y	1
Inden, M	1
Gregory, A	1
Yumnamcha, T	1
Shawky, M	1
Eltanani, S	1
Naghdi, A	1
Ross, BX	1
Lin, X	1
Ibrahim, AS	1
Provenzano, R	1
Tumlin, J	1
Zabaneh, R	1
Chou, J	1
Hemmerich, S	1
Neff, TB	1
Yu, KP	1
van Vliet, T	1
Varela-Eirin, M	1
Wang, B	1
Borghesan, M	1
Brandenburg, SM	1
Franzin, R	1
Evangelou, K	1
Seelen, M	1
Gorgoulis, V	1
Demaria, M	1
Jensen, BL	1
Liu, C	1
Jursa, T	1
Aschner, M	1
Smith, DR	1
Mukhopadhyay, S	1
Gao, X	1
Bi, Y	1
Chi, K	1
Liu, Y	1
Yuan, T	1
Li, X	3
Bi, W	1
Janjić, K	1
Lilaj, B	1
Moritz, A	1
Agis, H	1
Bhadange, Y	1
Lautert, J	1
Li, S	1
Lawando, E	1
Kim, ET	1
Soper, MC	1
Price, FW	1
Price, MO	1
Bonanno, JA	1
Xiong, W	1
Wu, Y	1
Xian, W	1
Song, L	1
Hu, L	1
Pan, S	1
Liu, M	1
Yao, S	1
Pei, L	1
Shang, Y	1
Ahmadipour, B	1
Sharifi, M	1
Khajali, F	1
Terasaki, M	1
Ogawa, Y	1
Endo, T	1
Maeda, H	1
Hamada, J	1
Osada, K	1
Miyashita, K	1
Mutoh, M	1
Zhou, X	1
Tang, S	1
Hu, K	1
Zhang, Z	1
Liu, P	1
Luo, Y	1
Kang, J	1
Xu, L	1
Boukatta, B	1
Sbai, H	1
Messaoudi, F	1
Lafrayiji, Z	1
El Bouazzaoui, A	1
Kanjaa, N	1
Forristal, CE	1
Levesque, JP	1
Bogdanova, OV	1
Abdullah, O	1
Kanekar, S	1
Bogdanov, VB	1
Prescot, AP	1
Renshaw, PF	1
Li, C	1
Guo, Z	1
Guo, B	1
Yang, J	1
Wang, A	1
Porteus, CS	1
Abdallah, SJ	1
Pollack, J	1
Kumai, Y	1
Kwong, RW	1
Yew, HM	1
Milsom, WK	1
Perry, SF	1
Connolly, NM	1
Düssmann, H	1
Anilkumar, U	1
Huber, HJ	1
Prehn, JH	1
Kim, D	1
Kim, I	1
Wang, J	1
White, C	1
Carroll, JL	1
Mokas, S	1
Larivière, R	1
Lamalice, L	1
Gobeil, S	1
Cornfield, DN	1
Agharazii, M	1
Richard, DE	1
Stecyk, JA	1
Skovgaard, N	1
Nilsson, GE	2
Wang, T	1
Solberg, R	1
Enot, D	1
Deigner, HP	1
Koal, T	1
Scholl-Bürgi, S	1
Saugstad, OD	1
Keller, M	1
Leger, AJ	1
Altobelli, A	1
Mosquea, LM	1
Belanger, AJ	1
Song, A	1
Cheng, SH	1
Jiang, C	1
Yew, NS	1
Lin, YK	1
Lai, MS	1
Chen, YC	1
Cheng, CC	1
Huang, JH	1
Chen, SA	1
Chen, YJ	1
Lin, CI	1
Fuchs, SA	1
Peeters-Scholte, CM	1
de Barse, MM	1
Roeleveld, MW	1
Klomp, LW	1
Berger, R	1
de Koning, TJ	1
Madden, JA	1
Ahlf, SB	1
Dantuma, MW	1
Olson, KR	1
Roerig, DL	1
Harsing, LG	1
Albert, M	1
Matyus, P	1
Szenasi, G	1
Makarenko, VV	1
Nanduri, J	1
Raghuraman, G	1
Fox, AP	1
Gadalla, MM	1
Kumar, GK	1
Snyder, SH	1
Prabhakar, NR	1
Malik, S	1
Vinukonda, G	1
Vose, LR	1
Diamond, D	1
Bhimavarapu, BB	1
Hu, F	1
Zia, MT	1
Hevner, R	1
Zecevic, N	1
Ballabh, P	1
St -John, WM	1
Rybak, IA	1
Paton, JF	1
Hasinoff, BB	1
Kawasaki, K	1
Ogawa, S	1
Khvatova, EM	1
Samartzev, VN	1
Zagoskin, PP	1
Prudchenko, IA	1
Mikhaleva, II	1
NEWEY, H	1
SMYTH, DH	1
SCHJEIDE, OA	1
ALEXANDER, GV	1
OKUNEWICK, JP	1
CARMACK, CR	1
WILKENS, M	1
CARLSEN, EN	1
HENNESSY, TG	1
MARQUIS, RE	1
GERHARDT, P	1
TURNER, MD	1
TURNER, AC	1
Jha, A	1
Dasgupta, S	1
Deshpande, SB	1
Sorrentino, DF	1
Fritz, KI	1
Haider, SH	1
Parikh, N	1
Papadopoulos, MD	1
Mishra, OP	2
Qingyou, Z	1
Junbao, D	1
Weijin, Z	1
Hui, Y	1
Chaoshu, T	1
Chunyu, Z	1
de Paula, PM	2
Branco, LG	2
Obach, M	1
Navarro-Sabaté, A	1
Caro, J	1
Kong, X	1
Duran, J	1
Gómez, M	1
Perales, JC	1
Ventura, F	1
Rosa, JL	1
Bartrons, R	1
Neff, RA	1
Simmens, SJ	1
Evans, C	1
Mendelowitz, D	1
Rodriguez-Sinovas, A	1
García-Dorado, D	1
Pina, P	1
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Trial	Phase	Enrollment	Study Type	Start Date	Status
A Clinical Pharmacological Study to Evaluate the Effects of Iron Supplements on the Pharmacokinetics of MT-6548 in Healthy Male Volunteers[NCT03645863]	Phase 3	61 participants (Actual)	Interventional	2018-08-27	Completed
Evaluation of the Capability of a Glycine Oral Supplement for Diminishing Bronchial Inflammation in Children With Cystic Fibrosis[NCT01417481]	Phase 2	13 participants (Actual)	Interventional	2012-03-31	Terminated (stopped due to Some of the researchers finished their participation in the study.)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Intervention	/h (Mean)
	MT-6548	MT-6548+Iron supplement C
Cohort 2	0.1356	0.1629

Intervention	/h (Mean)
	MT-6548	MT-6548+Iron supplement D
Cohort 3	0.1354	0.1518

Intervention	/h (Mean)
	MT-6548	MT-6548+Iron supplement A	MT-6548+Iron supplement B
Cohort 1	0.1314	0.1302	0.1647

Intervention	ug*h/mL (Mean)
	MT-6548	MT-6548+Iron supplement C
Cohort 2	100.2	47.7

Intervention	ug*h/mL (Mean)
	MT-6548	MT-6548+Iron supplement D
Cohort 3	129.3	16.0

Intervention	ug*h/mL (Mean)
	MT-6548	MT-6548+Iron supplement A	MT-6548+Iron supplement B
Cohort 1	105.3	49.2	37.2

Intervention	ug*h/mL (Mean)
	MT-6548	MT-6548+Iron supplement C
Cohort 2	96.3	46.4

Intervention	ug*h/mL (Mean)
	MT-6548	MT-6548+Iron supplement D
Cohort 3	125	14.9

Intervention	ug*h/mL (Mean)
	MT-6548	MT-6548+Iron supplement A	MT-6548+Iron supplement B
Cohort 1	100.4	47	36

Intervention	ug/mL (Mean)
	MT-6548	MT-6548+Iron supplement C
Cohort 2	15.5	9.37

Intervention	ug/mL (Mean)
	MT-6548	MT-6548+Iron supplement D
Cohort 3	27.1	2.65

Intervention	ug/mL (Mean)
	MT-6548	MT-6548+Iron supplement A	MT-6548+Iron supplement B
Cohort 1	14.5	7.76	5.96

Intervention	h (Mean)
	MT-6548	MT-6548+Iron supplement C
Cohort 2	6.97	5.76

Intervention	h (Mean)
	MT-6548	MT-6548+Iron supplement D
Cohort 3	6.56	7.21

Intervention	h (Mean)
	MT-6548	MT-6548+Iron supplement A	MT-6548+Iron supplement B
Cohort 1	8.23	8.06	7.28

Intervention	h (Mean)
	MT-6548	MT-6548+Iron supplement C
Cohort 2	5.22	4.4

Intervention	h (Mean)
	MT-6548	MT-6548+Iron supplement D
Cohort 3	5.23	5.05

Intervention	h (Mean)
	MT-6548	MT-6548+Iron supplement A	MT-6548+Iron supplement B
Cohort 1	5.38	5.39	4.33

Intervention	h (Median)
	MT-6548	MT-6548+Iron supplement C
Cohort 2	1.00	1.00

Intervention	h (Median)
	MT-6548	MT-6548+Iron supplement D
Cohort 3	2.00	3.00

Intervention	h (Median)
	MT-6548	MT-6548+Iron supplement A	MT-6548+Iron supplement B
Cohort 1	3.00	3.00	4.00

To correct for the baseline variability, all measurements were expressed as percentage of baseline (value at week 8 with respect to baseline value [beginning of the glycine or placebo period, respectively]). Then, percentages were log-transformed to adjust to a normal distribution. (NCT01417481)
Timeframe: 8 weeks

Changes in Sputum Concentration of Inflammatory Biomarkers (G-CSF)

Intervention	log (percent change) (Mean)
Glycine	-0.3908
Placebo	0.2035

To correct for the baseline variability, all measurements were expressed as percentage of baseline (value at week 8 with respect to baseline value [beginning of the glycine or placebo period, respectively]). Then, percentage change was log-transformed to adjust to a normal distribution. (NCT01417481)
Timeframe: 8 weeks

Changes in Sputum Concentration of Inflammatory Biomarkers (IL-6)

Intervention	log (percent change) (Mean)
Glycine	-0.0819
Placebo	0.1668

To correct for the baseline variability, all measurements were expressed as percentage of baseline (value at week 8 with respect to baseline value [beginning of the glycine or placebo period, respectively]). Then, percentage change was log-transformed to adjust to a normal distribution. (NCT01417481)
Timeframe: 8 weeks

Changes in Clinical Data Scores (Other Than Sputum Production, Dyspnea and Global Symptoms)

Intervention	log (percent change) (Mean)
Glycine	-0.00007
Placebo	0.1739

"To correct for the baseline variability, all measurements were expressed as percentage of baseline (value at week 8 with respect to baseline value [beginning of the glycine or placebo period, respectively]).~Each respiratory symptom (Cough severity, Sputum features, Appetite, Dyspnea, and Energy perception) was evaluated in a 5-options Likert scale, ranging from 1 (better) to 5 (worse). The total score was computed by the simple sum of the five symptoms." (NCT01417481)
Timeframe: 8 weeks

Changes in FEV1, FEF25, and FEFmax

Intervention	Percentage of baseline (Mean)
	Cough questionnaire score	Appetite questionnaire score	Energy questionnaire score	Body weight	Height	Heart rate	Respiratory rate	Temperature
Glycine	81.1	89.1	84.6	101.6	100.5	103.5	94.8	100.0
Placebo	89.1	132.1	111.5	103.6	100.5	98.1	109.0	100.1

Changes in Other Spirometric Variables

Intervention	Percentage of baseline (Mean)
	Forced expiratory volume at first second (FEV1)	Forced expiratory flow at 25%FVC (FEF25)	Maximal forced expiratory flow (FEFmax, PEFR)
Glycine	109.7	133.9	115.3
Placebo	91.4	83.3	91.2

Changes in Pulse Oximetry, FEV1/FVC, and FEF50.

Intervention	Percentage of baseline (Mean)
	Forced vital capacity (FVC)	Forced expiratory flow at 75%FVC (FEF75)
Glycine	104.1	111.8
Placebo	100.6	108.9

Changes in Score for Sputum Production, Dyspnea and Global Symptoms

Intervention	Percentage of baseline (Mean)
	Peripheral oxygen saturation (SpO2)	FEV1/FVC	Forced expiratory flow at 50%FVC (FEF50)
Glycine	105.2	105.2	115.5
Placebo	98.9	94.9	93.1

"To correct for the baseline variability, all measurements were expressed as percentage of baseline (value at week 8 with respect to baseline value [beginning of the glycine or placebo period, respectively]).~In the symptoms questionnaire, each respiratory symptom (Cough severity, Sputum features, Appetite, Dyspnea, and Energy perception) was evaluated in a 5-options Likert scale, ranging from 1 (better) to 5 (worse). The total score was computed by the simple sum of the five symptoms." (NCT01417481)
Timeframe: 8 weeks

Changes in Serum Concentration of Inflammatory Biomarkers (Other Than TNF-alpha)

Intervention	Percentage of baseline (Mean)
	Sputum questionnaire score	Dyspnea questionnaire score	Total questionnaire score
Glycine	82.0	75.6	77.7
Placebo	102.6	103.8	98.7

Changes in Sputum Concentration of Inflammatory Biomarkers (Other Than IL-6 and G-CSF)

Intervention	log (percent change) (Mean)
	Myeloperoxidase	IL-1	IL-4	IL-6	IL-7	IL-8	IL-12	IL-13	G-CSF	IFN-gamma	MCP-1	MIP-1beta
Glycine	-0.4361	-0.1635	0.2964	0.0085	0.0356	-0.1466	0.3203	-0.0561	-0.0776	0.3272	-0.0836	0.0330
Placebo	-0.2906	-0.0352	0.1470	0.2255	0.0819	-0.2364	0.2603	0.1953	0.2272	0.3639	0.0472	-0.0608

To correct for the baseline variability, all measurements were expressed as percentage of baseline (value at week 8 with respect to baseline value [beginning of the glycine or placebo period, respectively]). Then, percentage change was log-transformed to adjust to a normal distribution. (NCT01417481)
Timeframe: 8 weeks

Intervention	log (percent change) (Mean)
	Myeloperoxidase	IL-1	IL-2	IL-4	IL-5	IL-7	IL-8	IL-10	IL-12	IL-13	IL-17	IFN-gamma	MCP-1	MIP-1beta	TNF-alpha	GM-CSF
Glycine	0.1294	-0.0918	0.0233	-0.0161	0.2498	0.0611	-0.0824	0.0549	0.1675	0.1630	0.0680	0.0248	0.0042	-0.0303	0.0412	-0.0538
Placebo	0.0669	-0.0102	-0.0274	0.0522	0.1304	0.1387	0.0542	0.0074	0.0677	0.0953	0.1140	0.0649	0.2608	0.0977	0.1568	-0.0822

Article	Year
[Role of glutathione containing amino acids in the correction of body's dysadaptation states]. Problemy tuberkuleza, 1997, Issue:3 Topics: Adaptation, Physiological; Animals; Drug Therapy, Combination; Glutamic Acid; Glutathione; Glycine;	1997
Glycine: a new anti-inflammatory immunonutrient. Cellular and molecular life sciences : CMLS, 1999, Nov-30, Volume: 56, Issue:9-10 Topics: Alcohols; Animals; Anti-Inflammatory Agents; Calcium Channels, L-Type; Chloride Channels; Cyclospori	1999
Drugs acting on amino acid neurotransmitters. Advances in neurology, 1986, Volume: 43 Topics: Acoustic Stimulation; Amino Acids; Animals; Chemical Phenomena; Chemistry; Diazepam; Electrophysiolo	1986

Article	Year
In Vitro and Clinical Pharmacokinetic Studies of the Effects of Iron-containing Agents on Vadadustat, an Oral Hypoxia-inducible Factor-Prolyl Hydroxylase Inhibitor. Clinical therapeutics, 2021, Volume: 43, Issue:8 Topics: Glycine; Humans; Hypoxia; Iron; Male; Picolinic Acids; Prolyl-Hydroxylase Inhibitors	2021
Oral Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor Roxadustat (FG-4592) for Treatment of Anemia in Chronic Kidney Disease: A Placebo-Controlled Study of Pharmacokinetic and Pharmacodynamic Profiles in Hemodialysis Patients. Journal of clinical pharmacology, 2020, Volume: 60, Issue:11 Topics: Administration, Oral; Adult; Aged; Anemia; Area Under Curve; Dose-Response Relationship, Drug; Doubl	2020
Pulmonary hypertensive response of broiler chickens to arginine and guanidinoacetic acid under high-altitude hypoxia. Acta veterinaria Hungarica, 2018, Volume: 66, Issue:1 Topics: Altitude; Animals; Arginine; Chickens; Dietary Supplements; Glycine; Hypertension, Pulmonary; Hypoxi	2018

Article	Year
In vitro studies of hypoxia inducible factor-prolyl hydroxylase inhibitors daprodustat, desidustat, and vadadustat for equine doping control. Drug testing and analysis, 2022, Volume: 14, Issue:2 Topics: Animals; Barbiturates; Doping in Sports; Glycine; Horses; Hypoxia; Picolinic Acids; Prolyl-Hydroxyla	2022
Effects of Roxadustat on Erythropoietin Production in the Rat Body. Molecules (Basel, Switzerland), 2022, Feb-08, Volume: 27, Issue:3 Topics: Animals; Erythropoietin; Female; Glycine; Hypoxia; Isoquinolines; Kidney; Male; Prolyl-Hydroxylase I	2022
The HIFα-Stabilizing Drug Roxadustat Increases the Number of Renal Epo-Producing Sca-1 Cells, 2022, 02-21, Volume: 11, Issue:4 Topics: Anemia; Animals; Erythropoietin; Glycine; Hypoxia; Isoquinolines; Kidney; Mice; Procollagen-Proline	2022
Daprodustat in renal anaemia: changing the response to cellular hypoxia, but is it a game changer? Cardiovascular research, 2022, 06-29, Volume: 118, Issue:8 Topics: Anemia; Barbiturates; Cell Hypoxia; Glycine; Humans; Hypoxia; Renal Insufficiency, Chronic	2022
Daprodustat prevents cyclosporine-A-mediated anemia and peritubular capillary loss. Kidney international, 2022, Volume: 102, Issue:4 Topics: Anemia; Animals; Barbiturates; Calcineurin; Cyclosporine; Glycine; Hemoglobins; Hypoxia; Mice; Prote	2022
Cysteine and glycine-rich protein 2 promotes hypoxic pulmonary vascular smooth muscle cell proliferation through the Wnt3α-β-catenin/lymphoid enhancer-binding factor 1 pathway. Journal of biochemical and molecular toxicology, 2022, Volume: 36, Issue:9 Topics: Actins; beta Catenin; Cell Proliferation; Cells, Cultured; Cysteine; Glycine; Humans; Hypertension,	2022
HIF-α activation by the prolyl hydroxylase inhibitor roxadustat suppresses chemoresistant glioblastoma growth by inducing ferroptosis. Cell death & disease, 2022, 10-08, Volume: 13, Issue:10 Topics: Animals; Antineoplastic Agents; Basic Helix-Loop-Helix Transcription Factors; Cell Line, Tumor; Ferr	2022
Chronic intermittent hypoxia enhances glycinergic inhibition in nucleus tractus solitarius. Journal of neurophysiology, 2022, 12-01, Volume: 128, Issue:6 Topics: Animals; gamma-Aminobutyric Acid; Glycine; Hypoxia; Neural Inhibition; Rats; Rats, Sprague-Dawley; R	2022
The neuroprotective effects of FG-4592, a hypoxia-inducible factor-prolyl hydroxylase inhibitor, against oxidative stress induced by alpha-synuclein in N2a cells. Scientific reports, 2023, 09-20, Volume: 13, Issue:1 Topics: alpha-Synuclein; Glycine; Humans; Hypoxia; Neuroprotective Agents; Oxidative Stress; Parkinson Disea	2023
The Warburg effect alters amino acid homeostasis in human retinal endothelial cells: implication for proliferative diabetic retinopathy. Scientific reports, 2023, 09-25, Volume: 13, Issue:1 Topics: Diabetes Mellitus; Diabetic Retinopathy; Endothelial Cells; Fabaceae; Glycine; Homeostasis; Humans;	2023
Physiological hypoxia restrains the senescence-associated secretory phenotype via AMPK-mediated mTOR suppression. Molecular cell, 2021, 05-06, Volume: 81, Issue:9 Topics: Age Factors; AMP-Activated Protein Kinases; Animals; Antibiotics, Antineoplastic; Cell Hypoxia; Cell	2021
Get use to the -dustats: Roxadustat and molidustat, members of the hypoxia-inducible factor (HIF) prolyl hydroxylase (PHD) inhibitor drug class promote kidney function, perfusion and oxygenation in rats through nitric oxide. Acta physiologica (Oxford, England), 2021, Volume: 233, Issue:1 Topics: Animals; Glycine; Hypoxia; Isoquinolines; Kidney; Nitric Oxide; Perfusion; Pharmaceutical Preparatio	2021
Up-regulation of the manganese transporter SLC30A10 by hypoxia-inducible factors defines a homeostatic response to manganese toxicity. Proceedings of the National Academy of Sciences of the United States of America, 2021, 08-31, Volume: 118, Issue:35 Topics: Animals; Cation Transport Proteins; Glycine; Hep G2 Cells; Homeostasis; Humans; Hypoxia; Hypoxia-Ind	2021
Glycine-nitronyl nitroxide conjugate protects human umbilical vein endothelial cells against hypoxia/reoxygenation injury via multiple mechanisms and ameliorates hind limb ischemia/reperfusion injury in rats. Biochemical and biophysical research communications, 2017, 06-17, Volume: 488, Issue:1 Topics: Animals; Antioxidants; Apoptosis; Cells, Cultured; Glycine; Hindlimb; Human Umbilical Vein Endotheli	2017
Formation of spheroids by dental pulp cells in the presence of hypoxia and hypoxia mimetic agents. International endodontic journal, 2018, Volume: 51 Suppl 2 Topics: Chemokine CXCL12; Deferoxamine; Dental Pulp; Enzyme-Linked Immunosorbent Assay; Glycine; Humans; Hyp	2018
Hypoxia and the Prolyl Hydroxylase Inhibitor FG-4592 Protect Corneal Endothelial Cells From Mechanical and Perioperative Surgical Stress. Cornea, 2018, Volume: 37, Issue:4 Topics: Animals; Cell Line; Cell Survival; Corneal Endothelial Cell Loss; Cytoprotection; Descemet Stripping	2018
DAPK1-ERK signal mediates oxygen glucose deprivation reperfusion induced apoptosis in mouse N2a cells. Journal of the neurological sciences, 2018, 04-15, Volume: 387 Topics: Animals; Apoptosis; Cell Line, Tumor; Cerebral Cortex; Cytarabine; Death-Associated Protein Kinases;	2018
Glycine Is a Predictor for a Suppressive Effect of Fucoxanthinol on Colonosphere Formation Under Hypoxia. Anticancer research, 2018, Volume: 38, Issue:4 Topics: beta Carotene; Biomarkers, Tumor; Cell Proliferation; Drug Monitoring; Epithelial-Mesenchymal Transi	2018
DL-Propargylglycine protects against myocardial injury induced by chronic intermittent hypoxia through inhibition of endoplasmic reticulum stress. Sleep & breathing = Schlaf & Atmung, 2018, Volume: 22, Issue:3 Topics: Alkynes; Animals; Apoptosis; Cardiotonic Agents; Endoplasmic Reticulum Stress; Glycine; Hypoxia; Mal	2018
Transurethral resection of prostate syndrome: report of a case. The Pan African medical journal, 2013, Volume: 14 Topics: Absorption; Aged; Anesthesia, Spinal; Bradycardia; Coma; Combined Modality Therapy; Glycine; Humans;	2013
Targeting the hypoxia-sensing pathway in clinical hematology. Stem cells translational medicine, 2014, Volume: 3, Issue:2 Topics: Amino Acids, Dicarboxylic; Anemia; Apoptosis Regulatory Proteins; Aryl Hydrocarbon Receptor Nuclear	2014
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Inhibition of the endogenous CSE/H₂S system contributes to hypoxia and serum deprivation-induced apoptosis in mesenchymal stem cells. Molecular medicine reports, 2014, Volume: 9, Issue:6 Topics: Alkynes; Animals; Apoptosis; Cystathionine gamma-Lyase; Enzyme Activation; Gene Expression; Glycine;	2014
The role of hydrogen sulphide in the control of breathing in hypoxic zebrafish (Danio rerio). The Journal of physiology, 2014, Jul-15, Volume: 592, Issue:14 Topics: Alkynes; Aminooxyacetic Acid; Animals; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Glyci	2014
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Delta sleep inducing peptide (DSIP): effect on respiration activity in rat brain mitochondria and stress protective potency under experimental hypoxia. Peptides, 2003, Volume: 24, Issue:2 Topics: Animals; Brain; Delta Sleep-Inducing Peptide; Electron Transport; Glycine; Hypoxia; Male; Mitochondr	2003
Cellular mechanisms in intestinal transfer of amino acids. The Journal of physiology, 1962, Volume: 164 Topics: Amino Acids; Dipeptidases; Glycine; Hypoxia; Intestine, Small; Intestines; Methionine; Nitrophenols;	1962
SYNTHESIS OF CYTOPLASMIC HEMATIN BY NUCLEI OF ERYTHROCYTES FROM EMBRYOS. Growth, 1964, Volume: 28 Topics: Animals; Chick Embryo; Chromium Isotopes; Cytoplasm; DNA; Erythrocytes; Glycine; Heme; Hemin; Hemogl	1964
RESPIRATION-COUPLED AND PASSIVE UPTAKE OF ALPHA-AMINOISOBUTYRIC ACID, A METABOLICALLY INERT TRANSPORT ANALOGUE, BY BACILLUS MEGATERIUM. The Journal of biological chemistry, 1964, Volume: 239 Topics: Alanine; Aminobutyrates; Aminoisobutyric Acids; Bacillus megaterium; Carbon Isotopes; Chromatography	1964
EFFECTS OF HYPOXIA ON IN VIVO GLYCINE-C-14 INCORPORATION INTO PANCREATIC CELL PROTEINS. The American journal of physiology, 1965, Volume: 208 Topics: Acid Phosphatase; Amylases; Glycine; Hypoxia; Ion Exchange Resins; Pancreas; Proteins; Rats; Researc	1965
Effect of ischaemia & aglycaemia on the synaptic transmission in neonatal rat spinal cord in vitro. The Indian journal of medical research, 2003, Volume: 118 Topics: Animals; Animals, Newborn; Cell Hypoxia; Glucose; Glycine; Hypoxia; Ischemia; Magnesium; N-Methylasp	2003
Nitric oxide-mediated modification of the glycine binding site of the NMDA receptor during hypoxia in the cerebral cortex of the newborn piglet. Neurochemical research, 2004, Volume: 29, Issue:2 Topics: Animals; Animals, Newborn; Binding Sites; Cerebral Cortex; Enzyme Inhibitors; Glycine; Hypoxia; Inda	2004
Impact of hydrogen sulfide on carbon monoxide/heme oxygenase pathway in the pathogenesis of hypoxic pulmonary hypertension. Biochemical and biophysical research communications, 2004, Apr-23, Volume: 317, Issue:1 Topics: Alkynes; Animals; Blood Pressure; Carbon Monoxide; Cells, Cultured; Cystathionine gamma-Lyase; Enzym	2004
Glutamatergic neurotransmission modulates hypoxia-induced hyperventilation but not anapyrexia. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2004, Volume: 37, Issue:10 Topics: Animals; Benzoates; Body Temperature; Body Temperature Regulation; Excitatory Amino Acid Antagonists	2004
6-Phosphofructo-2-kinase (pfkfb3) gene promoter contains hypoxia-inducible factor-1 binding sites necessary for transactivation in response to hypoxia. The Journal of biological chemistry, 2004, Dec-17, Volume: 279, Issue:51 Topics: Animals; Binding Sites; Biotinylation; Blotting, Western; Cell Hypoxia; Cell Line; Cell Proliferatio	2004
Prenatal nicotine exposure alters central cardiorespiratory responses to hypoxia in rats: implications for sudden infant death syndrome. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004, Oct-20, Volume: 24, Issue:42 Topics: Action Potentials; Animals; Autonomic Fibers, Preganglionic; Female; gamma-Aminobutyric Acid; Glycin	2004
Effect of sarcolemmal rupture on myocardial electrical impedance during oxygen deprivation. American journal of physiology. Heart and circulatory physiology, 2005, Volume: 288, Issue:3 Topics: Acids; Animals; Cell Death; Cells, Cultured; Detergents; Electric Impedance; Energy Metabolism; Glyc	2005
mitoKATP channel activation in the postanoxic developing heart protects E-C coupling via NO-, ROS-, and PKC-dependent pathways. American journal of physiology. Heart and circulatory physiology, 2005, Volume: 288, Issue:4 Topics: Animals; Anti-Arrhythmia Agents; Atrioventricular Node; Chick Embryo; Chickens; Decanoic Acids; Diaz	2005
Glutamatergic receptors of the rostral ventrolateral medulla are involved in the ventilatory response to hypoxia. Respiratory physiology & neurobiology, 2005, Apr-15, Volume: 146, Issue:2-3 Topics: Animals; Benzoates; Body Temperature; Body Temperature Regulation; Drug Interactions; Excitatory Ami	2005
Effects of chronic hypoxia on MK-801-induced changes in the acute hypoxic ventilatory response. Journal of applied physiology (Bethesda, Md. : 1985), 2005, Volume: 99, Issue:6 Topics: Acetamides; Adaptation, Physiological; Animals; Chronic Disease; Dizocilpine Maleate; Glycine; Hypox	2005
Carnitine treatment inhibits increases in cerebral carnitine esters and glutamate detected by mass spectrometry after hypoxia-ischemia in newborn rats. Stroke, 2006, Volume: 37, Issue:2 Topics: Animals; Animals, Newborn; Anions; Brain; Cardiolipins; Carnitine; Carnitine O-Acetyltransferase; Gl	2006
Facilitation of spontaneous glycine release by anoxia potentiates NMDA receptor current in the hypoglossal motor neurons of the rat. The European journal of neuroscience, 2007, Volume: 25, Issue:6 Topics: Analysis of Variance; Animals; Animals, Newborn; Cyanates; Drug Interactions; Excitatory Amino Acid	2007
Inhibition of neutrophil elastase attenuates gut mucosal injury evoked by acute alveolar hypoxia in rabbits. Shock (Augusta, Ga.), 2007, Volume: 28, Issue:1 Topics: Acute Disease; Animals; Glycine; HMGB1 Protein; Hypoxia; Intestinal Mucosa; Leukocyte Elastase; Male	2007
Brainstem amino acid neurotransmitters and ventilatory response to hypoxia in piglets. Pediatric research, 2008, Volume: 63, Issue:1 Topics: Acid-Base Equilibrium; Amino Acids; Animals; Animals, Newborn; Aspartic Acid; Blood Pressure; Carbon	2008
Effects of anoxia on the stimulated release of amino acid neurotransmitters in the cerebellum in vitro. Journal of neurochemistry, 1983, Volume: 40, Issue:1 Topics: Amino Acids; Animals; Aspartic Acid; Brain Ischemia; Cerebellum; Female; gamma-Aminobutyric Acid; Gl	1983
Protein synthesis in the rat pulmonary trunk during the early development of hypoxia-induced pulmonary hypertension. Blood vessels, 1983, Volume: 20, Issue:6 Topics: Animals; Cardiomegaly; Collagen; Glycine; Hematocrit; Hydroxyproline; Hypertension, Pulmonary; Hypox	1983
Restriction of hypoxic membrane defect by glycine improves mitochondrial and cellular function in reoxygenated renal tubules. Advances in experimental medicine and biology, 1994, Volume: 361 Topics: Acetylglucosaminidase; Animals; Glutamate Dehydrogenase; Glycine; Hypoxia; In Vitro Techniques; Kidn	1994
The metabotropic glutamate receptor antagonist (+)-alpha-methyl-4-carboxyphenylglycine protects hippocampal CA1 neurons of the rat from in vitro hypoxia/hypoglycemia. Neuropharmacology, 1994, Volume: 33, Issue:5 Topics: Animals; Benzoates; Glucose; Glycine; Hippocampus; Hypoglycemia; Hypoxia; In Vitro Techniques; Neuro	1994
Cytoskeletal dissociation of ezrin during renal anoxia: role in microvillar injury. The American journal of physiology, 1994, Volume: 267, Issue:3 Pt 1 Topics: Actins; Animals; Antimycin A; Cell Membrane; Cytoskeletal Proteins; Cytoskeleton; Cytosol; Female; F	1994
23Na NMR detects protection by glycine and alanine against hypoxic injury in the isolated perfused rat kidney. Biochemical and biophysical research communications, 1994, Aug-15, Volume: 202, Issue:3 Topics: Alanine; Animals; Glycine; Hypoxia; In Vitro Techniques; Kidney Diseases; Magnetic Resonance Spectro	1994
Effect of anoxia on excitatory amino acids in brain slices of rats and turtles: in vitro microdialysis. The American journal of physiology, 1993, Volume: 264, Issue:4 Pt 2 Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Brain; Brain Stem; Dialysis; Glutamates; Glutamic Acid	1993
Glycine site of the excitatory amino acid N-methyl-D-aspartate receptor in neonatal and adult brain. Archives of disease in childhood, 1993, Volume: 69, Issue:2 Topics: Aged; Aged, 80 and over; Autoradiography; Brain; Brain Chemistry; Glycine; Humans; Hypoxia; Infant;	1993
Inhibition of nonlysosomal calcium-dependent proteolysis by glycine during anoxic injury of rat hepatocytes. Gastroenterology, 1994, Volume: 106, Issue:1 Topics: Animals; Calcium; Calpain; Cell Membrane Permeability; Cells, Cultured; Glycine; Hypoxia; Liver; Lys	1994
Glycine protects hepatocytes from injury caused by anoxia, cold ischemia and mitochondrial inhibitors, but not injury caused by calcium ionophores or oxidative stress. Hepatology (Baltimore, Md.), 1993, Volume: 17, Issue:1 Topics: Amino Acids; Animals; Calcimycin; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cold Temperature; Glyci	1993
Glycine protection against hypoxic but not phospholipase A2-induced injury in rat proximal tubules. The American journal of physiology, 1993, Volume: 264, Issue:1 Pt 2 Topics: Animals; Arachidonic Acid; Fatty Acids, Nonesterified; Glycine; Hypoxia; In Vitro Techniques; Kidney	1993
An increase in cytosolic protease activity during liver preservation. Inhibition by glutathione and glycine. Transplantation, 1993, Volume: 55, Issue:3 Topics: Animals; Aspartic Acid Endopeptidases; Cytosol; Endopeptidases; Glutathione; Glycine; Glycoside Hydr	1993
Extracellular neuroactive amino acids in the rat striatum during ischaemia: comparison between penumbral conditions and ischaemia with sustained anoxic depolarisation. Journal of neurochemistry, 1993, Volume: 61, Issue:1 Topics: Alanine; Amino Acids; Animals; Brain Ischemia; Corpus Striatum; Dialysis; Electroencephalography; El	1993
Beneficial effects of oxfenicine on the hypoxic rat atria. Archives of physiology and biochemistry, 1995, Volume: 103, Issue:1 Topics: Animals; Atrial Function; Carnitine O-Palmitoyltransferase; Enzyme Inhibitors; Fasting; Female; Glyc	1995
Hypoxia induces changes in phospholipase A2 in rat proximal tubules: evidence for multiple forms. The American journal of physiology, 1995, Volume: 269, Issue:6 Pt 2 Topics: Animals; Cell-Free System; Chemical Fractionation; Glycine; Hypoxia; Isoenzymes; Kidney Tubules, Pro	1995
Nitric oxide kinetics during hypoxia in proximal tubules: effects of acidosis and glycine. Kidney international, 1996, Volume: 49, Issue:5 Topics: Acidosis, Renal Tubular; Animals; Arginine; Glycine; Hydrogen-Ion Concentration; Hypoxia; In Vitro T	1996
Modification of the glycine (co-activator) binding site of the N-methyl-D-aspartate receptor in the guinea pig fetus brain during development following hypoxia. Brain research, 1996, Sep-09, Volume: 733, Issue:1 Topics: Animals; Binding Sites; Brain; Brain Chemistry; Female; Fetal Hypoxia; Fetus; Glycine; Glycine Agent	1996
Re: Delivery of inhaled aerosolized prostacyclin (IAP) Anaesthesia and intensive care, 1996, Volume: 24, Issue:5 Topics: Administration, Inhalation; Aerosols; Buffers; Epoprostenol; Equipment Design; Glycine; Humans; Hype	1996
Afferent input from peripheral chemoreceptors in response to hypoxia and amino acid neurotransmitter generation in the medulla. Advances in experimental medicine and biology, 1996, Volume: 410 Topics: Afferent Pathways; Animals; Chemoreceptor Cells; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Hy	1996
Loss of cytoskeletal support is not sufficient for anoxic plasma membrane disruption in renal cells. The American journal of physiology, 1997, Volume: 272, Issue:4 Pt 1 Topics: Animals; Cell Membrane; Cell Membrane Permeability; Cytochalasin D; Cytoskeleton; Dextrans; Female;	1997
PO2-dependent glomerular ultrafiltration of middle-weight protein is modified by protective amino acids. Advances in experimental medicine and biology, 1997, Volume: 411 Topics: alpha-Amylases; Amino Acids; Animals; gamma-Glutamyltransferase; Glycine; Hypoxia; In Vitro Techniqu	1997
Protection by glycine against hypoxia-reoxygenation induced hepatic injury. Research communications in molecular pathology and pharmacology, 1997, Volume: 97, Issue:2 Topics: Alanine Transaminase; Animals; Bile; Bile Ducts; Dose-Response Relationship, Drug; Glutathione; Glyc	1997
Acute and long-lasting effects of neonatal hypoxia on (+)-3-[125I]MK-801 binding to NMDA brain receptors. Experimental neurology, 1997, Volume: 148, Issue:1 Topics: Acute Disease; Animals; Animals, Newborn; Brain Chemistry; Brain Damage, Chronic; Dizocilpine Maleat	1997
Contribution of metabotropic glutamate receptors to the depression of excitatory postsynaptic potentials during hypoxia. Neuroreport, 1997, Dec-01, Volume: 8, Issue:17 Topics: Alanine; Animals; Benzoates; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials;	1997
Glycine protection against hypoxic injury in isolated rat proximal tubules: the role of proteases. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 1997, Volume: 12, Issue:12 Topics: Animals; Cytosol; Endopeptidases; Glycine; Hypoxia; In Vitro Techniques; Kidney Tubules, Proximal; M	1997
Dietary L-arginine prevents fetal growth restriction in rats. American journal of obstetrics and gynecology, 1998, Volume: 178, Issue:2 Topics: Animals; Arginine; Atmospheric Pressure; Diet; Embryonic and Fetal Development; Endothelins; Female;	1998
Gentle in situ liver manipulation during organ harvest decreases survival after rat liver transplantation: role of Kupffer cells. Transplantation, 1998, Apr-27, Volume: 65, Issue:8 Topics: Adenosine; Allopurinol; Animals; Cell Death; Dissection; Female; Gadolinium; Glutathione; Glycine; G	1998
Effects of fasting, hypoxia, methylpalmoxirate and oxfenicine on the tissue-levels of long-chain acyl CoA and acylcarnitine in the rat atria. Archives of physiology and biochemistry, 1997, Volume: 105, Issue:6 Topics: Acyl Coenzyme A; Aerobiosis; Animals; Carnitine; Carnitine O-Palmitoyltransferase; Cell Hypoxia; Enz	1997
Cyclosporin A increases hypoxia and free radical production in rat kidneys: prevention by dietary glycine. The American journal of physiology, 1998, Volume: 275, Issue:4 Topics: Animals; Creatinine; Cyclosporine; Food, Fortified; Free Radicals; Glomerular Filtration Rate; Glyci	1998
Neuroprotection against hypoxic/hypoglycaemic injury after the insult by the group III metabotropic glutamate receptor agonist (R, S)-4-phosphonophenylglycine. British journal of pharmacology, 2000, Volume: 131, Issue:4 Topics: Animals; Glutamic Acid; Glycine; Hypoglycemia; Hypoxia; Male; Neuroprotective Agents; Rats; Rats, Wi	2000
Conservation of phosphorylation state of cardiac phosphofructokinase during in vitro hypothermic hypoxia. American journal of physiology. Heart and circulatory physiology, 2000, Volume: 279, Issue:5 Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Alkanesulfonic Acids; Animal	2000
Inhibitory mechanisms in hypoxic respiratory depression studied in an in vitro preparation. Neuroscience research, 2000, Volume: 38, Issue:3 Topics: Animals; Cervical Vertebrae; Endorphins; Glycine; Hypoglossal Nerve; Hypoxia; In Vitro Techniques; N	2000
Disruption of KCC2 reveals an essential role of K-Cl cotransport already in early synaptic inhibition. Neuron, 2001, Volume: 30, Issue:2 Topics: Action Potentials; Animals; Animals, Newborn; Carrier Proteins; Embryo, Mammalian; Embryonic and Fet	2001
Characteristics of hippocampal glycine release in cell-damaging conditions in the adult and developing mouse. Neurochemical research, 2001, Volume: 26, Issue:7 Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfo	2001
Cyclosporin A causes a hypermetabolic state and hypoxia in the liver: prevention by dietary glycine. The Journal of pharmacology and experimental therapeutics, 2001, Volume: 299, Issue:3 Topics: Animals; Body Weight; Calcium; Chemical and Drug Induced Liver Injury; Cyclosporine; Dietary Supplem	2001
Protective effect of glycine on renal injury induced by ischemia-reperfusion in vivo. American journal of physiology. Renal physiology, 2002, Volume: 282, Issue:3 Topics: Animals; Electron Spin Resonance Spectroscopy; Female; Free Radicals; Glycine; Hypoxia; Kidney Disea	2002
Electrical properties and active solute transport in rat small intestine. I. Potential profile changes associated with sugar and amino acid transports. The Journal of membrane biology, 1977, Mar-08, Volume: 31, Issue:3 Topics: Animals; Biological Transport, Active; Duodenum; Female; Glucose; Glycine; Hypoxia; Ileum; Intestina	1977
Intestinal assimilation of a tetrapeptide in the rat. Obligate function of brush border aminopeptidase. The Journal of clinical investigation, 1977, Volume: 60, Issue:3 Topics: Aminopeptidases; Animals; Biological Transport; Glucose; Glycine; Hydrolysis; Hypoxia; In Vitro Tech	1977
Differences in coupling of energy to glycine and phenylalanine transport in aerobically grown Escherichia coli. Journal of bacteriology, 1975, Volume: 123, Issue:3 Topics: Adenosine Triphosphate; Aerobiosis; Azides; Biological Transport, Active; Cyanides; Dinitrophenols;	1975
Active amino-acid and sugar uptake by gall bladder epithelium in dog, guinea-pig and man. Pflugers Archiv : European journal of physiology, 1975, Apr-02, Volume: 355, Issue:4 Topics: Amino Acids; Animals; Biological Transport, Active; Cholestasis; Dinitrophenols; Dogs; Gallbladder;	1975
Mechanism of glycine protection in hypoxic injury: analogies with glycine receptor. Kidney international, 1992, Volume: 42, Issue:1 Topics: Animals; Dose-Response Relationship, Drug; Glycine; Hypoxia; In Vitro Techniques; Kidney; Kynurenic	1992
Protective effects of glutathione, glycine, or alanine in an in vitro model of renal anoxia. Journal of the American Society of Nephrology : JASN, 1992, Volume: 2, Issue:8 Topics: Alanine; Animals; Buthionine Sulfoximine; Cells, Cultured; Glutathione; Glycine; Hypoxia; Ischemia;	1992
Release of inhibitory neurotransmitters in response to anoxia in turtle brain. The American journal of physiology, 1991, Volume: 261, Issue:1 Pt 2 Topics: Alanine; Animals; Brain; Dialysis; Electrophysiology; Extracellular Space; gamma-Aminobutyric Acid;	1991
Intra- and extracellular changes of amino acids in the cerebral cortex of the neonatal rat during hypoxic-ischemia. Brain research. Developmental brain research, 1991, Dec-17, Volume: 64, Issue:1-2 Topics: Amino Acids; Animals; Animals, Newborn; Brain Ischemia; Cerebral Cortex; Energy Metabolism; Extracel	1991
Metabolic aspects of protection by glycine against hypoxic injury to isolated proximal tubules. Journal of the American Society of Nephrology : JASN, 1991, Volume: 1, Issue:7 Topics: Animals; Antimetabolites; Butyrates; Butyric Acid; Culture Media; Deoxyglucose; Glycine; Hypoxia; In	1991
Two-channel transporter versus a single-channel Na+-dependent transporter for glucose and amino acids in rat and turtle. Biomedical science, 1990, Volume: 1, Issue:6 Topics: Amino Acids; Animals; Biological Transport, Active; Dose-Response Relationship, Drug; Glycine; Hypox	1990
Relationships between intracellular amino acid levels and protection against injury to isolated proximal tubules. The American journal of physiology, 1991, Volume: 260, Issue:3 Pt 2 Topics: Amino Acids; Animals; Antimycin A; Freezing; Glycine; Hypoxia; In Vitro Techniques; Intracellular Me	1991
Effect of glycine on medullary thick ascending limb injury in perfused kidneys. Kidney international, 1991, Volume: 39, Issue:4 Topics: Amino Acids; Amphotericin B; Animals; Arginine; Glycine; Hypoxia; In Vitro Techniques; Indomethacin;	1991
Support of hypoxic renal cell volume regulation by glycine. Advances in experimental medicine and biology, 1990, Volume: 277 Topics: Animals; Gluconeogenesis; Glucose; Glycine; Hypoxia; In Vitro Techniques; Kidney; Kidney Cortex; Kid	1990
The effect of NMDA receptor glycine site antagonists on hypoxia-induced neurodegeneration of rat cortical cell cultures. Brain research, 1990, Oct-29, Volume: 531, Issue:1-2 Topics: Animals; Binding Sites; Cells, Cultured; Cerebral Cortex; Dizocilpine Maleate; Fetus; Glycine; Hypox	1990
Structural requirements for protection by small amino acids against hypoxic injury in kidney proximal tubules. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 1990, Volume: 4, Issue:15 Topics: Adenosine Triphosphate; Alanine; Amino Acids; Amino Acids, Cyclic; Animals; Dose-Response Relationsh	1990
Biochemistry and therapeutics of posthypoxic myoclonus. Advances in neurology, 1986, Volume: 43 Topics: 5-Hydroxytryptophan; Adrenocorticotropic Hormone; Aspartic Acid; Benzodiazepines; Carbidopa; Electro	1986
[The effect of oxygen starvation on the rate of acetate-1-C-14 and glycine-1-C-14 incorporation in the soluble brain and liver proteins of rats with different body temperatures]. Biulleten' eksperimental'noi biologii i meditsiny, 1974, Volume: 78, Issue:10 Topics: Acetates; Animals; Brain; Carbon Radioisotopes; Glycine; Hypothermia, Induced; Hypoxia; Liver; Male;	1974
Consequences of cerebral hypoxia examined at tissue-metabolic level. Monographs in neural sciences, 1973, Volume: 1 Topics: Anaerobiosis; Animals; Biological Transport, Active; Brain; Carbon Dioxide; Carbon Radioisotopes; Ce	1973
Effects of tetrodotoxin and anaesthetics on brain metabolism and transport during anoxia. The Biochemical journal, 1972, Volume: 126, Issue:4 Topics: Action Potentials; Amobarbital; Anesthetics; Anesthetics, Local; Animals; Aspartic Acid; Calcium; Ca	1972
Transport of amino acids by rabbit choroid plexus in vitro. Brain research, 1971, Jul-09, Volume: 30, Issue:1 Topics: Alanine; Amino Acids; Aminoisobutyric Acids; Animals; Biological Transport, Active; Carbon Isotopes;	1971
The ontogeny of amino acid transport in rat kidney. II. Kinetics of uptake and effect of anoxia. Biochimica et biophysica acta, 1971, Dec-03, Volume: 249, Issue:2 Topics: Aminoisobutyric Acids; Animals; Animals, Newborn; Biological Transport; Carbon Isotopes; Cyanides; D	1971
Mechanisms of dipeptide uptake by rat small intestine in vitro. Clinical science, 1971, Volume: 40, Issue:3 Topics: Amino Acid Oxidoreductases; Animals; Biological Transport, Active; Dipeptides; Glycine; Hypoxia; Ile	1971

glycine and Anoxemia

Research Excerpts

Research

Studies (122)

Authors

Clinical Trials (2)

Trial Overview

Trial Outcomes

Apparent Terminal Elimination Rate Constant (Kel) of Unchanged MT-6548

Apparent Terminal Elimination Rate Constant (Kel) of Unchanged MT-6548

Apparent Terminal Elimination Rate Constant (Kel) of Unchanged MT-6548

Area Under the Plasma Concentration-time Curve From Time Zero to Infinity(AUC0-∞) of Unchanged MT-6548

Area Under the Plasma Concentration-time Curve From Time Zero to Infinity(AUC0-∞) of Unchanged MT-6548

Area Under the Plasma Concentration-time Curve From Time Zero to Infinity(AUC0-∞) of Unchanged MT-6548

Area Under the Plasma Concentration-time Curve From Time Zero Until the Last Quantifiable Concentration (AUC0-last) of Unchanged MT-6548

Area Under the Plasma Concentration-time Curve From Time Zero Until the Last Quantifiable Concentration (AUC0-last) of Unchanged MT-6548

Area Under the Plasma Concentration-time Curve From Time Zero Until the Last Quantifiable Concentration (AUC0-last) of Unchanged MT-6548

Maximum Plasma Concentration (Cmax) of Unchanged MT-6548

Maximum Plasma Concentration (Cmax) of Unchanged MT-6548

Maximum Plasma Concentration (Cmax) of Unchanged MT-6548

Mean Residence Time From Zero to Infinity (MRT0-∞) of Unchanged MT-6548

Mean Residence Time From Zero to Infinity (MRT0-∞) of Unchanged MT-6548

Mean Residence Time From Zero to Infinity (MRT0-∞) of Unchanged MT-6548

Terminal Elimination Half-life (t1/2) of Unchanged MT-6548

Terminal Elimination Half-life (t1/2) of Unchanged MT-6548

Terminal Elimination Half-life (t1/2) of Unchanged MT-6548

Time to Reach Maximum Plasma Concentration (Tmax) of Unchanged MT-6548

Time to Reach Maximum Plasma Concentration (Tmax) of Unchanged MT-6548

Time to Reach Maximum Plasma Concentration (Tmax) of Unchanged MT-6548

Changes in Serum Concentration of Inflammatory Biomarkers (TNF-alpha)

Changes in Sputum Concentration of Inflammatory Biomarkers (G-CSF)

Changes in Sputum Concentration of Inflammatory Biomarkers (IL-6)

Changes in Clinical Data Scores (Other Than Sputum Production, Dyspnea and Global Symptoms)

Changes in FEV1, FEF25, and FEFmax

Changes in Other Spirometric Variables

Changes in Pulse Oximetry, FEV1/FVC, and FEF50.

Changes in Score for Sputum Production, Dyspnea and Global Symptoms

Changes in Serum Concentration of Inflammatory Biomarkers (Other Than TNF-alpha)

Changes in Sputum Concentration of Inflammatory Biomarkers (Other Than IL-6 and G-CSF)

Reviews

Trials

Other Studies