glycine has been researched along with Amyotrophic Lateral Sclerosis in 98 studies
Amyotrophic Lateral Sclerosis: A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The release of [(3)H]D-aspartate ([(3)H]D-ASP) or [(3)H]GABA evoked by glycine from spinal cord synaptosomes was compared in mice expressing mutant human SOD1 with a Gly(93) Ala substitution ([SOD1-G93A(+)]), a transgenic model of amyotrophic lateral sclerosis, and in control mice." | 7.72 | Activation of a glycine transporter on spinal cord neurons causes enhanced glutamate release in a mouse model of amyotrophic lateral sclerosis. ( Bonanno, G; Paolucci, E; Prisco, S; Raiteri, L; Raiteri, M, 2003) |
| "The aetiology of the sporadic form of amyotrophic lateral sclerosis (ALS) is poorly understood although abnormalities in glutamate and glycine transport have been implicated which both could contribute to a neurodegenerative process mediated through the N-methyl-D-aspartate (NMDA) receptor." | 7.69 | Induction of the immediate early gene c-jun in human spinal cord in amyotrophic lateral sclerosis with concomitant loss of NMDA receptor NR-1 and glycine transporter mRNA. ( de Belleroche, J; Virgo, L, 1995) |
| "Transmitter receptor binding was estimated in the spinal cord of 6 subjects with amyotrophic lateral sclerosis (ALS) and 4 control subjects in assays using 3H-quinuclidinyl benzilate for muscarinic cholinergic receptors, 3H-strychnine for glycinergic receptors, 3H-spiroperidol for dopaminergic receptors, 3H-muscimol for GABAergic receptors, and 3H-dihydroalprenolol for beta-adrenergic receptors." | 7.66 | Reduced glycine receptor in the spinal cord in amyotrophic lateral sclerosis. ( Hayashi, H; Satake, M; Suga, M; Tsubaki, T, 1981) |
| "The release of [(3)H]D-aspartate ([(3)H]D-ASP) or [(3)H]GABA evoked by glycine from spinal cord synaptosomes was compared in mice expressing mutant human SOD1 with a Gly(93) Ala substitution ([SOD1-G93A(+)]), a transgenic model of amyotrophic lateral sclerosis, and in control mice." | 3.72 | Activation of a glycine transporter on spinal cord neurons causes enhanced glutamate release in a mouse model of amyotrophic lateral sclerosis. ( Bonanno, G; Paolucci, E; Prisco, S; Raiteri, L; Raiteri, M, 2003) |
| "The aetiology of the sporadic form of amyotrophic lateral sclerosis (ALS) is poorly understood although abnormalities in glutamate and glycine transport have been implicated which both could contribute to a neurodegenerative process mediated through the N-methyl-D-aspartate (NMDA) receptor." | 3.69 | Induction of the immediate early gene c-jun in human spinal cord in amyotrophic lateral sclerosis with concomitant loss of NMDA receptor NR-1 and glycine transporter mRNA. ( de Belleroche, J; Virgo, L, 1995) |
| "Concentrations of glutamic acid have been reported to be elevated in fasting plasma and cerebrospinal fluid (CSF) of patients with amyotrophic lateral sclerosis (ALS); glycine concentrations have also been reported to be increased in the CSF of such patients." | 3.68 | Amyotrophic lateral sclerosis: amino acid levels in plasma and cerebrospinal fluid. ( Eisen, A; Hansen, S; Krieger, C; Perry, TL, 1990) |
| "Transmitter receptor binding was estimated in the spinal cord of 6 subjects with amyotrophic lateral sclerosis (ALS) and 4 control subjects in assays using 3H-quinuclidinyl benzilate for muscarinic cholinergic receptors, 3H-strychnine for glycinergic receptors, 3H-spiroperidol for dopaminergic receptors, 3H-muscimol for GABAergic receptors, and 3H-dihydroalprenolol for beta-adrenergic receptors." | 3.66 | Reduced glycine receptor in the spinal cord in amyotrophic lateral sclerosis. ( Hayashi, H; Satake, M; Suga, M; Tsubaki, T, 1981) |
| "FUS-positive inclusions in FTLD and ALS patients are consistently co-labeled with stress granule (SG) marker proteins." | 1.38 | Requirements for stress granule recruitment of fused in sarcoma (FUS) and TAR DNA-binding protein of 43 kDa (TDP-43). ( Bentmann, E; Dormann, D; Haass, C; Neumann, M; Rodde, R; Tahirovic, S, 2012) |
| "Amyotrophic lateral sclerosis (ALS) is a devastating disease characterized by upper and lower motor neuron damage." | 1.36 | Familial amyotrophic lateral sclerosis with a novel G85S mutation of superoxide dismutase 1 gene: clinical features of lower motor neuron disease. ( Hirayama, T; Ikeda, K; Ito, H; Iwasaki, Y; Kano, O; Kawabe, K; Nakamura, Y; Sobue, G; Takazawa, T; Tanaka, F; Yoshii, Y, 2010) |
| "We identified 1 patient with FTLD with a novel missense mutation, M254V, that was absent in 638 control individuals." | 1.36 | Genetic contribution of FUS to frontotemporal lobar degeneration. ( Cruts, M; De Deyn, PP; Engelborghs, S; Gijselinck, I; Mattheijssens, M; Peeters, K; Sleegers, K; Van Broeckhoven, C; Van den Broeck, M; van der Zee, J; Van Langenhove, T; Vandenberghe, R, 2010) |
| "Glycine 93 is a conserved residue at position i + 3 of a tight turn and has been found to be a mutational hot spot in familial amyotrophic lateral sclerosis (fALS)." | 1.33 | Calorimetric analysis of thermodynamic stability and aggregation for apo and holo amyotrophic lateral sclerosis-associated Gly-93 mutants of superoxide dismutase. ( Karbassi, F; Lepock, JR; Meiering, EM; Rumfeldt, JA; Siddall, CA; Stathopulos, PB, 2006) |
| " The possible toxic factor(s) and the exact mode of action (e." | 1.33 | Protective effect of metabotropic glutamate receptor inhibition on amyotrophic lateral sclerosis-cerebrospinal fluid toxicity in vitro. ( Anneser, JM; Borasio, GD; Chahli, C, 2006) |
| "One female patient with amyotrophic lateral sclerosis (ALS) was heterozygous for G12R mutation." | 1.32 | [Peculiarities of sporadic motor neuron disease associated with D90A and G12R mutations in Russian population]. ( Alekhin, AV; Brusov, OS; Karakhan, VB; Kondrat'eva, EA; Levitskaia, NI; Levitskiĭ, GN; Limborskaia, SA; Lysko, AI; Serdiuk, AV; Shadrina, MI; Skvortsova, VI; Slominskiĭ, PA, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (2.04) | 18.7374 |
| 1990's | 17 (17.35) | 18.2507 |
| 2000's | 44 (44.90) | 29.6817 |
| 2010's | 24 (24.49) | 24.3611 |
| 2020's | 11 (11.22) | 2.80 |
| Authors | Studies |
|---|---|
| Andrew, A | 1 |
| Zhou, J | 1 |
| Gui, J | 1 |
| Harrison, A | 1 |
| Shi, X | 1 |
| Li, M | 1 |
| Guetti, B | 1 |
| Nathan, R | 1 |
| Tischbein, M | 1 |
| Pioro, EP | 1 |
| Stommel, E | 1 |
| Bradley, W | 1 |
| Sonobe, Y | 1 |
| Aburas, J | 1 |
| Krishnan, G | 1 |
| Fleming, AC | 1 |
| Ghadge, G | 1 |
| Islam, P | 1 |
| Warren, EC | 1 |
| Gu, Y | 1 |
| Kankel, MW | 1 |
| Brown, AEX | 1 |
| Kiskinis, E | 2 |
| Gendron, TF | 2 |
| Gao, FB | 2 |
| Roos, RP | 2 |
| Kratsios, P | 1 |
| Verdone, BM | 2 |
| Cicardi, ME | 2 |
| Wen, X | 2 |
| Sriramoji, S | 1 |
| Russell, K | 1 |
| Markandaiah, SS | 1 |
| Jensen, BK | 2 |
| Krishnamurthy, K | 2 |
| Haeusler, AR | 2 |
| Pasinelli, P | 2 |
| Trotti, D | 3 |
| Gleixner, AM | 1 |
| Otte, CG | 1 |
| Anderson, EN | 1 |
| Ramesh, N | 1 |
| Shapiro, OR | 1 |
| Gale, JR | 1 |
| Mauna, JC | 1 |
| Mann, JR | 1 |
| Copley, KE | 1 |
| Daley, EL | 1 |
| Ortega, JA | 1 |
| Kofler, J | 1 |
| Pandey, UB | 1 |
| Donnelly, CJ | 1 |
| Jankowiak, T | 1 |
| Cholewiński, M | 1 |
| Bączyk, M | 1 |
| Laos, V | 1 |
| Do, TD | 1 |
| Bishop, D | 1 |
| Jin, Y | 1 |
| Marsh, NM | 1 |
| Quon, B | 1 |
| Fetters, M | 1 |
| Cantrell, KL | 1 |
| Buratto, SK | 1 |
| Bowers, MT | 1 |
| Niaki, AG | 1 |
| Sarkar, J | 1 |
| Cai, X | 1 |
| Rhine, K | 2 |
| Vidaurre, V | 1 |
| Guy, B | 1 |
| Hurst, M | 1 |
| Lee, JC | 1 |
| Koh, HR | 1 |
| Guo, L | 1 |
| Fare, CM | 2 |
| Shorter, J | 2 |
| Myong, S | 2 |
| Martin, E | 1 |
| Cazenave, W | 2 |
| Allain, AE | 2 |
| Cattaert, D | 1 |
| Branchereau, P | 2 |
| Ishiguro, A | 1 |
| Kimura, N | 1 |
| Noma, T | 1 |
| Shimo-Kon, R | 1 |
| Ishihama, A | 1 |
| Kon, T | 1 |
| Schuldi, MH | 1 |
| McAvoy, K | 1 |
| Russell, KA | 1 |
| Boehringer, A | 1 |
| Curran, BM | 1 |
| Westergard, T | 1 |
| Ma, L | 1 |
| Edbauer, D | 1 |
| Makurath, MA | 1 |
| Liu, J | 1 |
| Skanchy, S | 1 |
| Lopez, C | 1 |
| Catalan, KF | 1 |
| Ma, Y | 1 |
| Ha, T | 1 |
| Chemla, YR | 1 |
| Chattopadhyay, K | 1 |
| Srinivasan, E | 1 |
| Rajasekaran, R | 1 |
| Mochizuki, Y | 2 |
| Kawata, A | 3 |
| Hashimoto, T | 1 |
| Akiyama, H | 2 |
| Kawakami, H | 1 |
| Komori, T | 2 |
| Oyanagi, K | 2 |
| Mizutani, T | 2 |
| Matsubara, S | 1 |
| Yang, H | 1 |
| Wang, G | 1 |
| Sun, H | 1 |
| Shu, R | 1 |
| Liu, T | 1 |
| Wang, CE | 1 |
| Liu, Z | 1 |
| Zhao, Y | 1 |
| Zhao, B | 1 |
| Ouyang, Z | 1 |
| Yang, D | 2 |
| Huang, J | 1 |
| Zhou, Y | 1 |
| Li, S | 1 |
| Jiang, X | 1 |
| Xiao, Z | 1 |
| Li, XJ | 1 |
| Lai, L | 1 |
| Sassone, J | 1 |
| Taiana, M | 1 |
| Lombardi, R | 1 |
| Porretta-Serapiglia, C | 1 |
| Freschi, M | 1 |
| Bonanno, S | 2 |
| Marcuzzo, S | 2 |
| Caravello, F | 1 |
| Bendotti, C | 2 |
| Lauria, G | 1 |
| Lopez-Gonzalez, R | 1 |
| Lu, Y | 1 |
| Karydas, A | 1 |
| Tran, H | 1 |
| Petrucelli, L | 1 |
| Miller, BL | 1 |
| Almeida, S | 1 |
| Chang, Q | 1 |
| Martin, LJ | 1 |
| Muyderman, H | 1 |
| Hutson, PG | 1 |
| Matusica, D | 1 |
| Rogers, ML | 1 |
| Rush, RA | 1 |
| Museth, AK | 1 |
| Brorsson, AC | 1 |
| Lundqvist, M | 1 |
| Tibell, LA | 1 |
| Jonsson, BH | 1 |
| D'Ambrosi, N | 1 |
| Finocchi, P | 1 |
| Apolloni, S | 1 |
| Cozzolino, M | 1 |
| Ferri, A | 1 |
| Padovano, V | 1 |
| Pietrini, G | 1 |
| Carrì, MT | 1 |
| Volonté, C | 1 |
| Galaleldeen, A | 1 |
| Strange, RW | 1 |
| Whitson, LJ | 1 |
| Antonyuk, SV | 1 |
| Narayana, N | 1 |
| Taylor, AB | 1 |
| Schuermann, JP | 1 |
| Holloway, SP | 1 |
| Hasnain, SS | 1 |
| Hart, PJ | 2 |
| Pesiridis, GS | 1 |
| Lee, VM | 3 |
| Trojanowski, JQ | 3 |
| Yang, YS | 1 |
| Harel, NY | 1 |
| Strittmatter, SM | 1 |
| Takazawa, T | 1 |
| Ikeda, K | 1 |
| Hirayama, T | 1 |
| Kawabe, K | 1 |
| Nakamura, Y | 1 |
| Ito, H | 2 |
| Kano, O | 1 |
| Yoshii, Y | 1 |
| Tanaka, F | 1 |
| Sobue, G | 1 |
| Iwasaki, Y | 1 |
| Van Langenhove, T | 1 |
| van der Zee, J | 1 |
| Sleegers, K | 1 |
| Engelborghs, S | 1 |
| Vandenberghe, R | 1 |
| Gijselinck, I | 1 |
| Van den Broeck, M | 1 |
| Mattheijssens, M | 1 |
| Peeters, K | 1 |
| De Deyn, PP | 1 |
| Cruts, M | 1 |
| Van Broeckhoven, C | 1 |
| Wang, L | 1 |
| Grisotti, G | 1 |
| Nozaki, I | 1 |
| Arai, M | 1 |
| Takahashi, K | 1 |
| Hamaguchi, T | 1 |
| Yoshikawa, H | 1 |
| Muroishi, T | 1 |
| Noguchi-Shinohara, M | 1 |
| Itokawa, M | 1 |
| Yamada, M | 1 |
| Sasabe, J | 1 |
| Aiso, S | 1 |
| Yamamoto-Watanabe, Y | 1 |
| Watanabe, M | 1 |
| Jackson, M | 1 |
| Akimoto, H | 1 |
| Sugimoto, K | 1 |
| Yasujima, M | 1 |
| Wakasaya, Y | 1 |
| Matsubara, E | 1 |
| Kawarabayashi, T | 1 |
| Harigaya, Y | 1 |
| Lyndon, AR | 1 |
| Shoji, M | 1 |
| Yang, WW | 1 |
| Sidman, RL | 1 |
| Taksir, TV | 1 |
| Treleaven, CM | 1 |
| Fidler, JA | 1 |
| Cheng, SH | 1 |
| Dodge, JC | 1 |
| Shihabuddin, LS | 1 |
| Vargas, MR | 1 |
| Johnson, DA | 2 |
| Johnson, JA | 2 |
| Zucca, I | 1 |
| Mastropietro, A | 1 |
| de Rosbo, NK | 1 |
| Cavalcante, P | 1 |
| Tartari, S | 1 |
| Preite, L | 1 |
| Mantegazza, R | 1 |
| Bernasconi, P | 1 |
| Subramony, SH | 1 |
| Ashizawa, T | 1 |
| Langford, L | 1 |
| McKenna, R | 1 |
| Avvaru, B | 1 |
| Siddique, T | 2 |
| Vedanarayanan, V | 1 |
| Le Corronc, H | 1 |
| Delpy, A | 1 |
| Meyrand, P | 1 |
| Legendre, P | 1 |
| Liang, H | 1 |
| Ward, WF | 1 |
| Jang, YC | 1 |
| Bhattacharya, A | 1 |
| Bokov, AF | 1 |
| Li, Y | 1 |
| Jernigan, A | 1 |
| Richardson, A | 1 |
| Van Remmen, H | 1 |
| Moldovan, M | 1 |
| Alvarez, S | 1 |
| Pinchenko, V | 1 |
| Marklund, S | 1 |
| Graffmo, KS | 1 |
| Krarup, C | 1 |
| Bentmann, E | 1 |
| Neumann, M | 2 |
| Tahirovic, S | 1 |
| Rodde, R | 1 |
| Dormann, D | 1 |
| Haass, C | 1 |
| Giribaldi, F | 1 |
| Milanese, M | 1 |
| Bonifacino, T | 1 |
| Anna Rossi, PI | 1 |
| Di Prisco, S | 1 |
| Pittaluga, A | 1 |
| Tacchetti, C | 1 |
| Puliti, A | 1 |
| Usai, C | 1 |
| Bonanno, G | 2 |
| Kobayashi, J | 1 |
| Kuroda, M | 1 |
| Ikeuchi, T | 1 |
| Koide, R | 1 |
| McGown, A | 1 |
| McDearmid, JR | 1 |
| Panagiotaki, N | 1 |
| Tong, H | 1 |
| Al Mashhadi, S | 1 |
| Redhead, N | 1 |
| Lyon, AN | 1 |
| Beattie, CE | 1 |
| Shaw, PJ | 1 |
| Ramesh, TM | 1 |
| Wang, YT | 1 |
| Kuo, PH | 1 |
| Chiang, CH | 1 |
| Liang, JR | 1 |
| Chen, YR | 1 |
| Wang, S | 1 |
| Shen, JC | 1 |
| Yuan, HS | 1 |
| Valerio, A | 1 |
| Ferrario, M | 1 |
| Paterlini, M | 1 |
| Liberini, P | 1 |
| Moretto, G | 1 |
| Cairns, NJ | 1 |
| Pizzi, M | 1 |
| Spano, P | 1 |
| Shipp, EL | 1 |
| Cantini, F | 1 |
| Bertini, I | 2 |
| Valentine, JS | 4 |
| Banci, L | 2 |
| Raiteri, L | 1 |
| Paolucci, E | 1 |
| Prisco, S | 1 |
| Raiteri, M | 1 |
| Inoue, K | 1 |
| Fujimura, H | 1 |
| Ogawa, Y | 1 |
| Satoh, T | 1 |
| Shimada, K | 1 |
| Sakoda, S | 2 |
| Van Damme, P | 1 |
| Leyssen, M | 1 |
| Callewaert, G | 1 |
| Robberecht, W | 1 |
| Van Den Bosch, L | 1 |
| Kuo, JJ | 1 |
| Schonewille, M | 1 |
| Schults, AN | 1 |
| Fu, R | 1 |
| Bär, PR | 1 |
| Anelli, R | 1 |
| Heckman, CJ | 1 |
| Kroese, AB | 1 |
| Turner, BJ | 1 |
| Lopes, EC | 1 |
| Cheema, SS | 1 |
| Pieri, M | 1 |
| Gaetti, C | 1 |
| Spalloni, A | 2 |
| Cavalcanti, S | 1 |
| Mercuri, N | 2 |
| Bernardi, G | 2 |
| Longone, P | 2 |
| Zona, C | 2 |
| Skvortsova, VI | 1 |
| Limborskaia, SA | 1 |
| Slominskiĭ, PA | 1 |
| Levitskiĭ, GN | 1 |
| Levitskaia, NI | 1 |
| Shadrina, MI | 1 |
| Kondrat'eva, EA | 1 |
| Brusov, OS | 1 |
| Lysko, AI | 1 |
| Karakhan, VB | 1 |
| Alekhin, AV | 1 |
| Serdiuk, AV | 1 |
| Kirkinezos, IG | 1 |
| Hernandez, D | 1 |
| Bradley, WG | 1 |
| Moraes, CT | 1 |
| Sato, T | 1 |
| Yamamoto, Y | 1 |
| Nakanishi, T | 1 |
| Fukada, K | 1 |
| Sugai, F | 1 |
| Zhou, Z | 1 |
| Okuno, T | 1 |
| Nagano, S | 1 |
| Hirata, S | 1 |
| Shimizu, A | 1 |
| Atzori, C | 1 |
| Piva, R | 1 |
| Tortarolo, M | 1 |
| Strong, MJ | 1 |
| DeBiasi, S | 1 |
| Migheli, A | 1 |
| Albo, F | 1 |
| Ferrari, F | 1 |
| Mahoney, DJ | 1 |
| Rodriguez, C | 1 |
| Devries, M | 1 |
| Yasuda, N | 1 |
| Tarnopolsky, MA | 1 |
| Völkel, H | 1 |
| Selzle, M | 1 |
| Walk, T | 1 |
| Jung, G | 1 |
| Link, J | 1 |
| Ludolph, AC | 1 |
| Reuter, A | 1 |
| Zheng, C | 1 |
| Nennesmo, I | 1 |
| Fadeel, B | 1 |
| Henter, JI | 1 |
| Battistini, S | 1 |
| Giannini, F | 1 |
| Greco, G | 1 |
| Bibbò, G | 1 |
| Ferrera, L | 1 |
| Marini, V | 1 |
| Causarano, R | 1 |
| Casula, M | 1 |
| Lando, G | 1 |
| Patrosso, MC | 1 |
| Caponnetto, C | 1 |
| Origone, P | 1 |
| Marocchi, A | 1 |
| Del Corona, A | 1 |
| Siciliano, G | 1 |
| Carrera, P | 1 |
| Mascia, V | 1 |
| Giagheddu, M | 1 |
| Carcassi, C | 1 |
| Orrù, S | 1 |
| Garrè, C | 1 |
| Penco, S | 1 |
| Morahan, JM | 1 |
| Yu, B | 1 |
| Trent, RJ | 1 |
| Pamphlett, R | 1 |
| Stathopulos, PB | 1 |
| Rumfeldt, JA | 1 |
| Karbassi, F | 1 |
| Siddall, CA | 1 |
| Lepock, JR | 1 |
| Meiering, EM | 1 |
| Stewart, HG | 1 |
| Mackenzie, IR | 1 |
| Eisen, A | 2 |
| Brännström, T | 1 |
| Marklund, SL | 1 |
| Andersen, PM | 1 |
| Anneser, JM | 1 |
| Chahli, C | 1 |
| Borasio, GD | 1 |
| Beers, DR | 1 |
| Henkel, JS | 1 |
| Xiao, Q | 1 |
| Zhao, W | 1 |
| Wang, J | 1 |
| Yen, AA | 1 |
| Siklos, L | 1 |
| McKercher, SR | 1 |
| Appel, SH | 1 |
| Gal, J | 1 |
| Ström, AL | 1 |
| Kilty, R | 1 |
| Zhang, F | 1 |
| Zhu, H | 1 |
| Kiaei, M | 1 |
| Kipiani, K | 1 |
| Calingasan, NY | 1 |
| Wille, E | 1 |
| Chen, J | 1 |
| Heissig, B | 1 |
| Rafii, S | 1 |
| Lorenzl, S | 1 |
| Beal, MF | 2 |
| Messi, ML | 1 |
| Clark, HM | 1 |
| Prevette, DM | 1 |
| Oppenheim, RW | 1 |
| Delbono, O | 1 |
| Kraft, AD | 1 |
| Resch, JM | 1 |
| D'Amelio, N | 1 |
| Libralesso, E | 1 |
| Turano, P | 1 |
| Andreadou, E | 1 |
| Kapaki, E | 1 |
| Kokotis, P | 1 |
| Paraskevas, GP | 1 |
| Katsaros, N | 1 |
| Libitaki, G | 1 |
| Zis, V | 1 |
| Sfagos, C | 1 |
| Vassilopoulos, D | 1 |
| Suzuki, M | 1 |
| Irie, T | 1 |
| Watanabe, T | 1 |
| Mikami, H | 1 |
| Yamazaki, T | 1 |
| Ono, S | 1 |
| Kabashi, E | 1 |
| Agar, JN | 1 |
| Hong, Y | 1 |
| Taylor, DM | 1 |
| Minotti, S | 1 |
| Figlewicz, DA | 1 |
| Durham, HD | 1 |
| Lee, JK | 1 |
| Shin, JH | 1 |
| Suh, J | 1 |
| Choi, IS | 1 |
| Ryu, KS | 1 |
| Gwag, BJ | 1 |
| Van Deerlin, VM | 1 |
| Leverenz, JB | 1 |
| Bekris, LM | 1 |
| Bird, TD | 1 |
| Yuan, W | 1 |
| Elman, LB | 1 |
| Clay, D | 1 |
| Wood, EM | 1 |
| Chen-Plotkin, AS | 1 |
| Martinez-Lage, M | 1 |
| Steinbart, E | 1 |
| McCluskey, L | 1 |
| Grossman, M | 1 |
| Wu, IL | 1 |
| Yang, WS | 1 |
| Kalb, R | 1 |
| Galasko, DR | 1 |
| Montine, TJ | 1 |
| Schellenberg, GD | 1 |
| Yu, CE | 1 |
| Hayashi, H | 1 |
| Suga, M | 1 |
| Satake, M | 1 |
| Tsubaki, T | 1 |
| Winterbourn, CC | 1 |
| Domigan, NM | 1 |
| Broom, JK | 1 |
| Virgo, L | 1 |
| de Belleroche, J | 1 |
| Nishida, CR | 1 |
| Gralla, EB | 2 |
| Borchelt, DR | 2 |
| Lee, MK | 1 |
| Slunt, HS | 1 |
| Guarnieri, M | 1 |
| Xu, ZS | 1 |
| Wong, PC | 1 |
| Brown, RH | 1 |
| Price, DL | 1 |
| Sisodia, SS | 1 |
| Cleveland, DW | 2 |
| Rainero, I | 1 |
| Pinessi, L | 1 |
| Tsuda, T | 1 |
| Vignocchi, MG | 1 |
| Vaula, G | 1 |
| Calvi, L | 1 |
| Cerrato, P | 1 |
| Rossi, B | 1 |
| Bergamini, L | 1 |
| McLachlan, DR | 1 |
| Tu, PH | 1 |
| Raju, P | 1 |
| Robinson, KA | 1 |
| Gurney, ME | 1 |
| Rodríguez-Ithurralde, D | 1 |
| Olivera, S | 1 |
| Vincent, O | 1 |
| Maruri, A | 1 |
| Liu, H | 1 |
| Pellegrini, M | 1 |
| Nersissian, AM | 1 |
| Eisenberg, D | 1 |
| Klivenyi, P | 1 |
| Ferrante, RJ | 1 |
| Matthews, RT | 1 |
| Bogdanov, MB | 1 |
| Klein, AM | 1 |
| Andreassen, OA | 1 |
| Mueller, G | 1 |
| Wermer, M | 1 |
| Kaddurah-Daouk, R | 1 |
| Almer, G | 1 |
| Vukosavic, S | 1 |
| Romero, N | 1 |
| Przedborski, S | 1 |
| Ratovitski, T | 1 |
| Corson, LB | 1 |
| Strain, J | 1 |
| Wong, P | 1 |
| Culotta, VC | 1 |
| Niebroj-Dobosz, I | 3 |
| Janik, P | 2 |
| Mariotti, R | 1 |
| Bentivoglio, M | 1 |
| Aĭrapetian, KV | 1 |
| Zavalishin, IA | 1 |
| Nikitin, SS | 1 |
| Barkhatova, VP | 1 |
| Comoletti, D | 1 |
| Muzio, V | 1 |
| Capobianco, A | 1 |
| Ravizza, T | 1 |
| Mennini, T | 1 |
| Kostera-Pruszczyk, A | 1 |
| Emeryk-Szajewska, B | 1 |
| Karwańska, A | 1 |
| Rowińska-Marcińska, K | 1 |
| Kwieciński, H | 1 |
| Boehme, DH | 1 |
| Marks, N | 1 |
| Fordice, MW | 1 |
| Testa, D | 1 |
| Caraceni, T | 1 |
| Fetoni, V | 1 |
| Girotti, F | 1 |
| Plaitakis, A | 2 |
| Roufs, JB | 1 |
| Perry, TL | 1 |
| Krieger, C | 1 |
| Hansen, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Longitudinal Assessment of Autonomic and Sensory Nervous System in ALS[NCT05747937] | 100 participants (Anticipated) | Interventional | 2021-05-15 | Recruiting | |||
| Identification of Genes Causing Familial ALS or Increasing Risk for Sporadic ALS and ALS With Frontotemporal Dementia and Understanding Disease Mechanism.[NCT00821132] | 13,521 participants (Actual) | Observational | 1991-01-31 | Completed | |||
| Sport Therapy for Contrasting the Deterioration of Muscle Oxidative Metabolism in Patients Affected by Amyotrophic Lateral Sclerosis (ALS) - Project ME_E_SLA[NCT02548663] | 30 participants (Actual) | Interventional | 2014-06-30 | Completed | |||
| Quantifying Fatigue of the Respiratory and Swallowing Musculature in Patients With Amyotrophic Lateral Sclerosis[NCT04468191] | 0 participants (Actual) | Interventional | 2021-02-10 | Withdrawn (stopped due to COVID-19 pandemic restrictions for data collection) | |||
| The Role of Moderate Aerobic Exercise as Determined by Cardiopulmonary Exercise Testing in ALS[NCT03326622] | 48 participants (Actual) | Interventional | 2013-07-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for glycine and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
The human G93A-superoxide dismutase-1 mutation, mitochondrial glutathione and apoptotic cell death.
Topics: Alanine; Amino Acid Substitution; Amyotrophic Lateral Sclerosis; Animals; Apoptosis; Cell Death; Glu | 2009 |
Mutations in TDP-43 link glycine-rich domain functions to amyotrophic lateral sclerosis.
Topics: Amino Acid Sequence; Amyotrophic Lateral Sclerosis; DNA-Binding Proteins; Glycine; Humans; Immunohis | 2009 |
Aberrant control of motoneuronal excitability in amyotrophic lateral sclerosis: excitatory glutamate/D-serine vs. inhibitory glycine/gamma-aminobutanoic acid (GABA).
Topics: Amyotrophic Lateral Sclerosis; Excitatory Amino Acids; gamma-Aminobutyric Acid; Glutamic Acid; Glyci | 2010 |
Maturation of the GABAergic transmission in normal and pathologic motoneurons.
Topics: Adult; Amyotrophic Lateral Sclerosis; Animals; Central Nervous System; Chlorides; gamma-Aminobutyric | 2011 |
Altered glutamatergic mechanisms and selective motor neuron degeneration in amyotrophic lateral sclerosis: possible role of glycine.
Topics: Amyotrophic Lateral Sclerosis; Animals; Glutamates; Glutamic Acid; Glutamine; Glycine; Humans; Motor | 1991 |
3 trials available for glycine and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
Motor unit hyperexcitability in amyotrophic lateral sclerosis vs amino acids acting as neurotransmitters.
Topics: Adult; Aged; Amino Acids; Amyotrophic Lateral Sclerosis; Aspartic Acid; Chromatography, High Pressur | 2002 |
Effect of Riluzole on serum amino acids in patients with amyotrophic lateral sclerosis.
Topics: Adult; Aged; Amino Acids; Amyotrophic Lateral Sclerosis; Aspartic Acid; Chromatography, High Pressur | 2002 |
Chronic treatment with L-threonine in amyotrophic lateral sclerosis: a pilot study.
Topics: Administration, Oral; Adult; Aged; Amyotrophic Lateral Sclerosis; Drug Administration Schedule; Fema | 1992 |
90 other studies available for glycine and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
Pesticides applied to crops and amyotrophic lateral sclerosis risk in the U.S.
Topics: 2,4-Dichlorophenoxyacetic Acid; Aged; Aged, 80 and over; Amyotrophic Lateral Sclerosis; Carbaryl; Ch | 2021 |
A C. elegans model of C9orf72-associated ALS/FTD uncovers a conserved role for eIF2D in RAN translation.
Topics: Alanine; Amyotrophic Lateral Sclerosis; Animals; Arginine; C9orf72 Protein; Caenorhabditis elegans; | 2021 |
A mouse model with widespread expression of the C9orf72-linked glycine-arginine dipeptide displays non-lethal ALS/FTD-like phenotypes.
Topics: Amyotrophic Lateral Sclerosis; Animals; Arginine; C9orf72 Protein; Dipeptides; Female; Frontotempora | 2022 |
NUP62 localizes to ALS/FTLD pathological assemblies and contributes to TDP-43 insolubility.
Topics: Amyotrophic Lateral Sclerosis; C9orf72 Protein; Dipeptides; DNA Repeat Expansion; DNA-Binding Protei | 2022 |
Differential Effects of Invasive Anodal Trans-spinal Direct Current Stimulation on Monosynaptic Excitatory Postsynaptic Potentials, Ia Afferents Excitability, and Motoneuron Intrinsic Properties Between Superoxide Dismutase Type-1 Glycine to Alanine Subst
Topics: Alanine; Amyotrophic Lateral Sclerosis; Animals; Electric Stimulation Therapy; Excitatory Postsynapt | 2022 |
Characterizing TDP-43
Topics: Amyotrophic Lateral Sclerosis; Circular Dichroism; DNA-Binding Proteins; Glycine; Humans; Microscopy | 2019 |
Loss of Dynamic RNA Interaction and Aberrant Phase Separation Induced by Two Distinct Types of ALS/FTD-Linked FUS Mutations.
Topics: Active Transport, Cell Nucleus; Amyotrophic Lateral Sclerosis; Frontotemporal Dementia; Glycine; Hum | 2020 |
Implication of 5-HT in the Dysregulation of Chloride Homeostasis in Prenatal Spinal Motoneurons from the G93A Mouse Model of Amyotrophic Lateral Sclerosis.
Topics: Action Potentials; Amyotrophic Lateral Sclerosis; Animals; Chlorides; Female; gamma-Aminobutyric Aci | 2020 |
Molecular dissection of ALS-linked TDP-43 - involvement of the Gly-rich domain in interaction with G-quadruplex mRNA.
Topics: Amyotrophic Lateral Sclerosis; DNA-Binding Proteins; G-Quadruplexes; Glycine; HEK293 Cells; Humans; | 2020 |
Synaptic dysfunction induced by glycine-alanine dipeptides in C9orf72-ALS/FTD is rescued by SV2 replenishment.
Topics: Alanine; Amyotrophic Lateral Sclerosis; Animals; C9orf72 Protein; Dipeptides; Frontotemporal Dementi | 2020 |
ALS/FTLD-Linked Mutations in FUS Glycine Residues Cause Accelerated Gelation and Reduced Interactions with Wild-Type FUS.
Topics: Amyotrophic Lateral Sclerosis; Frontotemporal Dementia; Glycine; Humans; Inclusion Bodies; Mutation; | 2020 |
Probing the influence of mutations on FUS condensates, one molecule at a time.
Topics: Amyotrophic Lateral Sclerosis; Frontotemporal Lobar Degeneration; Glycine; Humans; Mutation; RNA-Bin | 2021 |
Exploring the cause of aggregation and reduced Zn binding affinity by G85R mutation in SOD1 rendering amyotrophic lateral sclerosis.
Topics: Amino Acid Substitution; Amyotrophic Lateral Sclerosis; Arginine; Binding Sites; Glycine; Humans; Mo | 2017 |
An autopsy case of familial amyotrophic lateral sclerosis with FUS R521G mutation.
Topics: Aged; Amyotrophic Lateral Sclerosis; Arginine; Autopsy; Female; Glycine; Humans; Mutation; RNA-Bindi | 2014 |
Species-dependent neuropathology in transgenic SOD1 pigs.
Topics: Alanine; Amino Acid Substitution; Amyotrophic Lateral Sclerosis; Animals; Animals, Genetically Modif | 2014 |
ALS mouse model SOD1G93A displays early pathology of sensory small fibers associated to accumulation of a neurotoxic splice variant of peripherin.
Topics: Alanine; Alternative Splicing; Amino Acid Substitution; Amyotrophic Lateral Sclerosis; Animals; Cell | 2016 |
Poly(GR) in C9ORF72-Related ALS/FTD Compromises Mitochondrial Function and Increases Oxidative Stress and DNA Damage in iPSC-Derived Motor Neurons.
Topics: Amyotrophic Lateral Sclerosis; Arginine; Blotting, Western; C9orf72 Protein; Cell Line; Dipeptides; | 2016 |
Glycinergic innervation of motoneurons is deficient in amyotrophic lateral sclerosis mice: a quantitative confocal analysis.
Topics: Acetylcholine; Amyotrophic Lateral Sclerosis; Animals; Choline O-Acetyltransferase; Fluorescent Anti | 2009 |
The ALS-associated mutation G93A in human copper-zinc superoxide dismutase selectively destabilizes the remote metal binding region.
Topics: Alanine; Amyotrophic Lateral Sclerosis; Copper; Glycine; Humans; Protein Binding; Protein Stability; | 2009 |
The proinflammatory action of microglial P2 receptors is enhanced in SOD1 models for amyotrophic lateral sclerosis.
Topics: Alanine; Amino Acid Substitution; Amyotrophic Lateral Sclerosis; Animals; Cell Line, Transformed; Ce | 2009 |
Structural and biophysical properties of metal-free pathogenic SOD1 mutants A4V and G93A.
Topics: Alanine; Amino Acid Substitution; Amyotrophic Lateral Sclerosis; Copper; Crystallography, X-Ray; Gen | 2009 |
Reticulon-4A (Nogo-A) redistributes protein disulfide isomerase to protect mice from SOD1-dependent amyotrophic lateral sclerosis.
Topics: Alanine; Amyotrophic Lateral Sclerosis; Animals; Chlorocebus aethiops; COS Cells; Glycine; Male; Mic | 2009 |
Familial amyotrophic lateral sclerosis with a novel G85S mutation of superoxide dismutase 1 gene: clinical features of lower motor neuron disease.
Topics: Adult; Amyotrophic Lateral Sclerosis; Fatal Outcome; Female; Glycine; Humans; Male; Motor Neuron Dis | 2010 |
Genetic contribution of FUS to frontotemporal lobar degeneration.
Topics: Aged; Amino Acid Sequence; Amyotrophic Lateral Sclerosis; DNA Mutational Analysis; DNA-Binding Prote | 2010 |
Mutant SOD1 knockdown in all cell types ameliorates disease in G85R SOD1 mice with a limited additional effect over knockdown restricted to motor neurons.
Topics: Amyotrophic Lateral Sclerosis; Animals; Arginine; Disease Models, Animal; Estrogen Antagonists; Glyc | 2010 |
Familial ALS with G298S mutation in TARDBP: a comparison of CSF tau protein levels with those in sporadic ALS.
Topics: Amino Acid Substitution; Amyotrophic Lateral Sclerosis; DNA-Binding Proteins; Glycine; Humans; Male; | 2010 |
Quantification of cystatin C in cerebrospinal fluid from various neurological disorders and correlation with G73A polymorphism in CST3.
Topics: Aged; Aged, 80 and over; Alanine; Alzheimer Disease; Amyotrophic Lateral Sclerosis; Biomarkers; Case | 2010 |
Relationship between neuropathology and disease progression in the SOD1(G93A) ALS mouse.
Topics: Alanine; Amino Acid Substitution; Amyotrophic Lateral Sclerosis; Animals; Disease Models, Animal; Di | 2011 |
Decreased glutathione accelerates neurological deficit and mitochondrial pathology in familial ALS-linked hSOD1(G93A) mice model.
Topics: Alanine; Amyotrophic Lateral Sclerosis; Animals; Cells, Cultured; Coculture Techniques; Disease Mode | 2011 |
Hind limb muscle atrophy precedes cerebral neuronal degeneration in G93A-SOD1 mouse model of amyotrophic lateral sclerosis: a longitudinal MRI study.
Topics: Alanine; Amyotrophic Lateral Sclerosis; Animals; Brain; Disease Models, Animal; Glycine; Hindlimb; H | 2011 |
Confirmation of the severe phenotypic effect of serine at codon 41 of the superoxide dismutase 1 gene.
Topics: Adult; Amyotrophic Lateral Sclerosis; Family Health; Female; Glycine; Humans; Male; Middle Aged; Mod | 2011 |
PGC-1α protects neurons and alters disease progression in an amyotrophic lateral sclerosis mouse model.
Topics: Alanine; Amino Acid Substitution; Amyotrophic Lateral Sclerosis; Animals; Disease Models, Animal; Di | 2011 |
Nerve excitability changes related to axonal degeneration in amyotrophic lateral sclerosis: Insights from the transgenic SOD1(G127X) mouse model.
Topics: Amyotrophic Lateral Sclerosis; Animals; Axons; Differential Threshold; Disease Models, Animal; Elect | 2012 |
Requirements for stress granule recruitment of fused in sarcoma (FUS) and TAR DNA-binding protein of 43 kDa (TDP-43).
Topics: Amyotrophic Lateral Sclerosis; Binding Sites; Cerebral Cortex; DNA-Binding Proteins; Frontotemporal | 2012 |
Group I metabotropic glutamate autoreceptors induce abnormal glutamate exocytosis in a mouse model of amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; Autoreceptors; Calcium; Disease Models, Anima | 2013 |
Novel G37V mutation of SOD1 gene in autopsied patient with familial amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Asian People; Autopsy; Glycine; Humans; Male; Middle Aged; Mutation, | 2012 |
Early interneuron dysfunction in ALS: insights from a mutant sod1 zebrafish model.
Topics: Amyotrophic Lateral Sclerosis; Animals; Animals, Genetically Modified; Apomorphine; Disease Models, | 2013 |
The truncated C-terminal RNA recognition motif of TDP-43 protein plays a key role in forming proteinaceous aggregates.
Topics: Amino Acid Motifs; Amyloidogenic Proteins; Amyotrophic Lateral Sclerosis; Benzothiazoles; Chromatogr | 2013 |
Spinal cord mGlu1a receptors: possible target for amyotrophic lateral sclerosis therapy.
Topics: Amyotrophic Lateral Sclerosis; Animals; Cell Survival; Excitatory Amino Acid Agonists; Excitatory Am | 2002 |
Dynamic properties of the G93A mutant of copper-zinc superoxide dismutase as detected by NMR spectroscopy: implications for the pathology of familial amyotrophic lateral sclerosis.
Topics: Alanine; Amyotrophic Lateral Sclerosis; Copper; Glycine; Humans; Models, Molecular; Nuclear Magnetic | 2003 |
Activation of a glycine transporter on spinal cord neurons causes enhanced glutamate release in a mouse model of amyotrophic lateral sclerosis.
Topics: Age Factors; Amino Acid Transport Systems, Neutral; Amyotrophic Lateral Sclerosis; Animals; D-Aspart | 2003 |
Familial amyotrophic lateral sclerosis with a point mutation (G37R) of the superoxide dismutase 1 gene: a clinicopathological study.
Topics: Amyotrophic Lateral Sclerosis; Arginine; Brain Stem; DNA Mutational Analysis; Exons; Glycine; Humans | 2002 |
The AMPA receptor antagonist NBQX prolongs survival in a transgenic mouse model of amyotrophic lateral sclerosis.
Topics: Age Factors; Alanine; Amyotrophic Lateral Sclerosis; Analysis of Variance; Animals; Behavior, Animal | 2003 |
Hyperexcitability of cultured spinal motoneurons from presymptomatic ALS mice.
Topics: Action Potentials; Alanine; Amyotrophic Lateral Sclerosis; Animals; Animals, Newborn; Disease Models | 2004 |
The serotonin precursor 5-hydroxytryptophan delays neuromuscular disease in murine familial amyotrophic lateral sclerosis.
Topics: 5-Hydroxytryptophan; Aging; Alanine; Amyotrophic Lateral Sclerosis; Animals; Animals, Newborn; Body | 2003 |
alpha-Amino-3-hydroxy-5-methyl-isoxazole-4-propionate receptors in spinal cord motor neurons are altered in transgenic mice overexpressing human Cu,Zn superoxide dismutase (Gly93-->Ala) mutation.
Topics: Alanine; Amyotrophic Lateral Sclerosis; Animals; Cell Culture Techniques; Disease Models, Animal; El | 2003 |
[Peculiarities of sporadic motor neuron disease associated with D90A and G12R mutations in Russian population].
Topics: Aged; Aged, 80 and over; Amyotrophic Lateral Sclerosis; Arginine; Copper; Disease Progression; Elect | 2003 |
An ALS mouse model with a permeable blood-brain barrier benefits from systemic cyclosporine A treatment.
Topics: Age Factors; Alanine; Amyotrophic Lateral Sclerosis; Animals; ATP Binding Cassette Transporter, Subf | 2004 |
Identification of two novel mutations in the Cu/Zn superoxide dismutase gene with familial amyotrophic lateral sclerosis: mass spectrometric and genomic analyses.
Topics: Age of Onset; Amyotrophic Lateral Sclerosis; Aspartic Acid; Chromatography, Liquid; DNA Mutational A | 2004 |
Activated p38MAPK is a novel component of the intracellular inclusions found in human amyotrophic lateral sclerosis and mutant SOD1 transgenic mice.
Topics: Age Factors; Aged; Alanine; Amyotrophic Lateral Sclerosis; Animals; Female; Glycine; Humans; Immunoh | 2004 |
Cu/Zn-superoxide dismutase (GLY93-->ALA) mutation alters AMPA receptor subunit expression and function and potentiates kainate-mediated toxicity in motor neurons in culture.
Topics: Alanine; Amyotrophic Lateral Sclerosis; Animals; Cells, Cultured; Drug Resistance; Fetus; Genetic Pr | 2004 |
Effects of high-intensity endurance exercise training in the G93A mouse model of amyotrophic lateral sclerosis.
Topics: Alanine; Amino Acid Substitution; Amyotrophic Lateral Sclerosis; Animals; Disease Models, Animal; Fe | 2004 |
Effects of high-intensity endurance exercise training in the G93A mouse model of amyotrophic lateral sclerosis.
Topics: Alanine; Amino Acid Substitution; Amyotrophic Lateral Sclerosis; Animals; Disease Models, Animal; Fe | 2004 |
Effects of high-intensity endurance exercise training in the G93A mouse model of amyotrophic lateral sclerosis.
Topics: Alanine; Amino Acid Substitution; Amyotrophic Lateral Sclerosis; Animals; Disease Models, Animal; Fe | 2004 |
Effects of high-intensity endurance exercise training in the G93A mouse model of amyotrophic lateral sclerosis.
Topics: Alanine; Amino Acid Substitution; Amyotrophic Lateral Sclerosis; Animals; Disease Models, Animal; Fe | 2004 |
Effects of high-intensity endurance exercise training in the G93A mouse model of amyotrophic lateral sclerosis.
Topics: Alanine; Amino Acid Substitution; Amyotrophic Lateral Sclerosis; Animals; Disease Models, Animal; Fe | 2004 |
Effects of high-intensity endurance exercise training in the G93A mouse model of amyotrophic lateral sclerosis.
Topics: Alanine; Amino Acid Substitution; Amyotrophic Lateral Sclerosis; Animals; Disease Models, Animal; Fe | 2004 |
Effects of high-intensity endurance exercise training in the G93A mouse model of amyotrophic lateral sclerosis.
Topics: Alanine; Amino Acid Substitution; Amyotrophic Lateral Sclerosis; Animals; Disease Models, Animal; Fe | 2004 |
Effects of high-intensity endurance exercise training in the G93A mouse model of amyotrophic lateral sclerosis.
Topics: Alanine; Amino Acid Substitution; Amyotrophic Lateral Sclerosis; Animals; Disease Models, Animal; Fe | 2004 |
Effects of high-intensity endurance exercise training in the G93A mouse model of amyotrophic lateral sclerosis.
Topics: Alanine; Amino Acid Substitution; Amyotrophic Lateral Sclerosis; Animals; Disease Models, Animal; Fe | 2004 |
Reduced reactivation rate in mutant CuZnSOD and progression rate of amyotrophic lateral sclerosis.
Topics: Alanine; Amyotrophic Lateral Sclerosis; Bacteria; Blotting, Western; Cloning, Molecular; Copper; Dis | 2004 |
Vascular endothelial growth factor prolongs survival in a transgenic mouse model of ALS.
Topics: Age Factors; Alanine; Amyotrophic Lateral Sclerosis; Animals; Disease Models, Animal; Glycine; Human | 2004 |
SOD1 mutations in amyotrophic lateral sclerosis. Results from a multicenter Italian study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amyotrophic Lateral Sclerosis; Blotting, Northern; Cohor | 2005 |
Screening the metallothionein III gene in sporadic amyotrophic lateral sclerosis.
Topics: Aged; Amyotrophic Lateral Sclerosis; Cysteine; Female; Gene Frequency; Genetic Testing; Genotype; Gl | 2005 |
Calorimetric analysis of thermodynamic stability and aggregation for apo and holo amyotrophic lateral sclerosis-associated Gly-93 mutants of superoxide dismutase.
Topics: Amino Acid Substitution; Amyotrophic Lateral Sclerosis; Apoenzymes; Calorimetry, Differential Scanni | 2006 |
Clinicopathological phenotype of ALS with a novel G72C SOD1 gene mutation mimicking a myopathy.
Topics: Aged; Amyotrophic Lateral Sclerosis; Blotting, Western; Creatine; Cysteine; DNA Mutational Analysis; | 2006 |
Protective effect of metabotropic glutamate receptor inhibition on amyotrophic lateral sclerosis-cerebrospinal fluid toxicity in vitro.
Topics: Aged; Amyotrophic Lateral Sclerosis; Animals; Cell Count; Cell Death; Cells, Cultured; Cerebrospinal | 2006 |
Wild-type microglia extend survival in PU.1 knockout mice with familial amyotrophic lateral sclerosis.
Topics: Aging; Amyotrophic Lateral Sclerosis; Animals; Animals, Newborn; Bone Marrow Cells; Bone Marrow Tran | 2006 |
p62 accumulates and enhances aggregate formation in model systems of familial amyotrophic lateral sclerosis.
Topics: Adaptor Proteins, Signal Transducing; Amyotrophic Lateral Sclerosis; Animals; Cell Line; Cell Surviv | 2007 |
Matrix metalloproteinase-9 regulates TNF-alpha and FasL expression in neuronal, glial cells and its absence extends life in a transgenic mouse model of amyotrophic lateral sclerosis.
Topics: ADAM Proteins; ADAM17 Protein; Alanine; Amyotrophic Lateral Sclerosis; Animals; Fas Ligand Protein; | 2007 |
The lack of effect of specific overexpression of IGF-1 in the central nervous system or skeletal muscle on pathophysiology in the G93A SOD-1 mouse model of ALS.
Topics: Alanine; Amyotrophic Lateral Sclerosis; Animals; Cell Size; Cell Survival; Central Nervous System; G | 2007 |
Activation of the Nrf2-ARE pathway in muscle and spinal cord during ALS-like pathology in mice expressing mutant SOD1.
Topics: Alanine; Alkaline Phosphatase; Amyotrophic Lateral Sclerosis; Animals; Antioxidants; Gene Expression | 2007 |
Metalation of the amyotrophic lateral sclerosis mutant glycine 37 to arginine superoxide dismutase (SOD1) apoprotein restores its structural and dynamical properties in solution to those of metalated wild-type SOD1.
Topics: Amino Acid Substitution; Amyotrophic Lateral Sclerosis; Apoenzymes; Arginine; Copper; Electron Spin | 2007 |
Plasma glutamate and glycine levels in patients with amyotrophic lateral sclerosis: the effect of riluzole treatment.
Topics: Aged; Amyotrophic Lateral Sclerosis; Chromatography, High Pressure Liquid; Disease Progression; Fema | 2008 |
Familial amyotrophic lateral sclerosis with Gly93Ser mutation in Cu/Zn superoxide dismutase: a clinical and neuropathological study.
Topics: Adult; Amyotrophic Lateral Sclerosis; Central Nervous System; Family Health; Female; Glycine; Humans | 2008 |
Proteasomes remain intact, but show early focal alteration in their composition in a mouse model of amyotrophic lateral sclerosis.
Topics: Alanine; Amyotrophic Lateral Sclerosis; Animals; Disease Models, Animal; Glycine; Humans; Mice; Mice | 2008 |
Tissue inhibitor of metalloproteinases-3 (TIMP-3) expression is increased during serum deprivation-induced neuronal apoptosis in vitro and in the G93A mouse model of amyotrophic lateral sclerosis: a potential modulator of Fas-mediated apoptosis.
Topics: Alanine; Amino Acid Substitution; Amyotrophic Lateral Sclerosis; Animals; Apoptosis; Cell Line, Tumo | 2008 |
TARDBP mutations in amyotrophic lateral sclerosis with TDP-43 neuropathology: a genetic and histopathological analysis.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alanine; Amyotrophic Lateral Sclerosis; Brain; Child; De | 2008 |
Reduced glycine receptor in the spinal cord in amyotrophic lateral sclerosis.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Animals; Binding, Competitive; Glycine; Humans; Middle A | 1981 |
Decreased thermal stability of red blood cell glu100-->gly superoxide dismutase from a family with amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Enzyme Stability; Erythrocytes; Glutamic Acid; Glycine; Humans; Point | 1995 |
Induction of the immediate early gene c-jun in human spinal cord in amyotrophic lateral sclerosis with concomitant loss of NMDA receptor NR-1 and glycine transporter mRNA.
Topics: Adult; Aged; Amino Acid Transport Systems, Neutral; Amyotrophic Lateral Sclerosis; Blotting, Norther | 1995 |
Characterization of three yeast copper-zinc superoxide dismutase mutants analogous to those coded for in familial amyotrophic lateral sclerosis.
Topics: Alanine; Amino Acid Sequence; Amyotrophic Lateral Sclerosis; Arginine; Edetic Acid; Glycine; Humans; | 1994 |
Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity.
Topics: Amino Acid Sequence; Amyotrophic Lateral Sclerosis; Arginine; Base Sequence; Cell Line; Cloning, Mol | 1994 |
SOD1 missense mutation in an Italian family with ALS.
Topics: Adult; Amyotrophic Lateral Sclerosis; Base Sequence; Chromosomes, Human, Pair 21; DNA; DNA Primers; | 1994 |
Transgenic mice carrying a human mutant superoxide dismutase transgene develop neuronal cytoskeletal pathology resembling human amyotrophic lateral sclerosis lesions.
Topics: Aging; Alanine; Amino Acid Sequence; Amyotrophic Lateral Sclerosis; Animals; Cytoskeleton; Glycine; | 1996 |
In vivo and in vitro studies of glycine- and glutamate-evoked acetylcholinesterase release from spinal motor neurones: implications for amyotrophic lateral sclerosis/motor neurone disease pathogenesis.
Topics: Acetylcholinesterase; Amyotrophic Lateral Sclerosis; Animals; Calcium; Glutamic Acid; Glycine; Histo | 1997 |
Subunit asymmetry in the three-dimensional structure of a human CuZnSOD mutant found in familial amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Arginine; Binding Sites; Copper; Crystallography, X-Ray; Dimerization | 1998 |
Neuroprotective effects of creatine in a transgenic animal model of amyotrophic lateral sclerosis.
Topics: Alanine; Amyotrophic Lateral Sclerosis; Animals; Creatine; Disease Models, Animal; Glycine; Humans; | 1999 |
Inducible nitric oxide synthase up-regulation in a transgenic mouse model of familial amyotrophic lateral sclerosis.
Topics: Alanine; Amino Acid Substitution; Amyotrophic Lateral Sclerosis; Animals; Astrocytes; Gene Expressio | 1999 |
Variation in the biochemical/biophysical properties of mutant superoxide dismutase 1 enzymes and the rate of disease progression in familial amyotrophic lateral sclerosis kindreds.
Topics: Amino Acid Substitution; Amyotrophic Lateral Sclerosis; Animals; Centrifugation; Copper; COS Cells; | 1999 |
Amino acids acting as transmitters in amyotrophic lateral sclerosis (ALS).
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Brain; Cell Death; Chromatography, High P | 1999 |
Activation and response to axotomy of microglia in the facial motor nuclei of G93A superoxide dismutase transgenic mice.
Topics: Alanine; Amyotrophic Lateral Sclerosis; Animals; Axotomy; Disease Models, Animal; Facial Nerve; Glyc | 2000 |
[Physiopathological and chemopathological mechanisms of central motor disorders in amyotrophic lateral sclerosis].
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Brain; Electromyography; Female; Glutamic | 2000 |
Nitric oxide produced by non-motoneuron cells enhances rat embryonic motoneuron sensitivity to excitotoxins: comparison in mixed neuron/glia or purified cultures.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amyotrophic Lateral Sclerosis; Animals; An | 2001 |
Glycine levels in the degenerated human spinal cord.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Glycine; Humans; Middle Aged; Nerve Degeneration; Spinal | 1976 |
L-threonine as a symptomatic treatment for amyotrophic lateral sclerosis (ALS).
Topics: Amyotrophic Lateral Sclerosis; Central Nervous System; Glycine; Humans; Models, Biological; Threonin | 1991 |
Glutamate dysfunction and selective motor neuron degeneration in amyotrophic lateral sclerosis: a hypothesis.
Topics: Amyotrophic Lateral Sclerosis; Central Nervous System; Glutamate Dehydrogenase; Glutamates; Glutamic | 1990 |
Amyotrophic lateral sclerosis: amino acid levels in plasma and cerebrospinal fluid.
Topics: Adult; Aged; Amino Acids; Amyotrophic Lateral Sclerosis; Female; Glutamates; Glycine; Humans; Male; | 1990 |