glycine has been researched along with Acute Confusional Senile Dementia in 79 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "BI 425809 is a potent and selective glycine transporter 1 (GlyT1) inhibitor being developed for the treatment of cognitive impairment in Alzheimer disease and schizophrenia." | 5.27 | Evaluation of Pharmacokinetics and Pharmacodynamics of BI 425809, a Novel GlyT1 Inhibitor: Translational Studies. ( Desch, M; Dorner-Ciossek, C; Fillon, G; Giovannini, R; Goetz, S; Keller, S; Kleiner, O; Liesenfeld, KH; Moschetti, V; Ramael, S; Rosenbrock, H; Schlecker, C; Schmid, B; Wind, S; Wunderlich, G, 2018) |
| "D-Cycloserine was associated with significant improvement in scores on the cognitive subscale of the Alzheimer's Disease Assessment Scale (improvement of 3." | 2.69 | Improved cognition in Alzheimer's disease with short-term D-cycloserine treatment. ( Coyle, JT; Falk, WE; Gunther, J; Tsai, GE, 1999) |
| " So far it is not clear whether NMDA receptor antagonists including glycine antagonists would be suitable for chronic administration because of their effects on cognition, learning and motor function." | 2.40 | The glycine site on the NMDA receptor: structure-activity relationships and possible therapeutic applications. ( Dannhardt, G; Kohl, BK, 1998) |
| "Early onset Familial Alzheimer's Disease (FAD) is an autosomal dominant disease with apparent complete penetrance." | 2.38 | Alzheimer's disease families with amyloid precursor protein mutations. ( Frackowiak, RS; Kennedy, AM; Lantos, P; Newman, S; Rossor, MN, 1993) |
| "Glyphosate has been shown to cross the blood-brain barrier in in vitro models, but has yet to be verified in vivo." | 1.72 | Glyphosate infiltrates the brain and increases pro-inflammatory cytokine TNFα: implications for neurodegenerative disorders. ( Huentelman, MJ; Pathak, KV; Piras, IS; Pirrotte, P; Sharma, R; Velazquez, R; White, J; Winslow, W; Winstone, JK, 2022) |
| "Neurodegeneration in Alzheimer's disease (AD) is closely associated with the accumulation of pathologic tau aggregates in the form of neurofibrillary tangles." | 1.56 | Autosomal dominant VCP hypomorph mutation impairs disaggregation of PHF-tau. ( Aguirre, GK; Changolkar, L; Darwich, NF; Gibbons, GS; Grossman, M; He, Z; Irwin, DJ; Kim, B; Lee, EB; Luk, KC; Massimo, L; McMillan, CT; Nasrallah, IM; Nguyen, AT; O'Rourke, CM; Papageorgiou, SG; Papatriantafyllou, JD; Phan, JM; Porta, S; Suh, E; Toro, C; Van Deerlin, VM, 2020) |
| "Despite intense efforts, the cause of Alzheimer's disease is still not fully understood." | 1.56 | Secondary Chemical Bonding between Insoluble Calcium Oxalate and Carbonyl Oxygen Atoms of GLY and VAL Residues Triggers the Formation of Aβ Aggregates and Their Deposition in the Brain. ( Gan, T; Liu, Q; Ma, X; Shi, Y; Wang, Y; Zhang, X, 2020) |
| "Increasing evidence suggest that Alzheimer's disease (AD) is a heterogeneous disorder that includes several subtypes with different etiology and progression." | 1.40 | Decreased cerebrospinal fluid levels of L-carnitine in non-apolipoprotein E4 carriers at early stages of Alzheimer's disease. ( Cedazo-Mínguez, Á; Cifuentes, A; Ibáñez, C; Lodeiro, M; Simó, C, 2014) |
| "A major characteristic of Alzheimer's disease is the presence of amyloid beta (Aβ) oligomers and aggregates in the brain." | 1.39 | Inhibition of amyloid beta-induced synaptotoxicity by a pentapeptide derived from the glycine zipper region of the neurotoxic peptide. ( Aguayo, LG; Burgos, CF; Castillo, C; Espinoza, MP; Fernandez-Perez, EJ; Opazo, C; Peters, C; Streltsov, VA; Urrutia, JC, 2013) |
| "A central question in Alzheimer's disease (AD) research is what role β-amyloid peptide (Aβ) plays in synaptic dysfunction." | 1.37 | Impaired β-amyloid secretion in Alzheimer's disease pathogenesis. ( Capetillo-Zarate, E; Gouras, GK; Lin, MT; Rahman, N; Tampellini, D, 2011) |
| "Alzheimer's disease is a neurodegenerative disorder characterized by amyloid deposits and neurofibrillary tangles." | 1.35 | Early Tau pathology involving the septo-hippocampal pathway in a Tau transgenic model: relevance to Alzheimer's disease. ( Belarbi, K; Blum, D; Buée, L; Burnouf, S; Caillierez, R; Demeyer, D; Grosjean, ME; Hamdane, M; Schindowski, K; Sergeant, N, 2009) |
| "Humanin is a newly identified 24-residue peptide that suppresses neuronal cell death caused by a wide spectrum of familial Alzheimer's disease genes and the beta-amyloid peptide." | 1.33 | Solution structure of humanin, a peptide against Alzheimer's disease-related neurotoxicity. ( Benaki, D; Evangelou, A; Livaniou, E; Mikros, E; Pelecanou, M; Vlassi, M; Zikos, C, 2005) |
| "Since Alzheimer's disease is known to be associated with down-regulation of the cholinergic and N-methyl-D-aspartate (NMDA) systems, most of these drugs inhibit acetylcholinesterase, potentiate the activity of nicotinic acetylcholine receptors (nAChRs), or modulate NMDA receptors." | 1.33 | In vitro galantamine-memantine co-application: mechanism of beneficial action. ( Huang, J; Marszalec, W; Narahashi, T; Toth, PT; Yeh, JZ; Zhao, X, 2006) |
| "The Radical Model of Alzheimer's Disease (AD) is presented in some detail." | 1.31 | The radical model of Alzheimer's disease: specific recognition of Gly29 and Gly33 by Met35 in a beta-sheet model of Abeta: an ONIOM study. ( Brunelle, P; Rauk, A, 2002) |
| " Moreover, we show that the toxic and protective CuBD phenotypes are associated with differences in Cu binding and reduction." | 1.31 | Contrasting, species-dependent modulation of copper-mediated neurotoxicity by the Alzheimer's disease amyloid precursor protein. ( Beyreuther, K; Cappai, R; Galatis, D; Masters, CL; McKinstry, WJ; Multhaup, G; Parker, MW; Pipkorn, R; White, AR, 2002) |
| "The findings suggest that in Alzheimer's disease the glycine modulatory site of the NMDA receptor complex is affected to a small extent by the loss of glutamatergic terminals which has previously been demonstrated." | 1.28 | Binding to the glycine site of the NMDA receptor complex in brains of patients with Alzheimer's disease. ( Del Bel, EA; Slater, P, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (7.59) | 18.7374 |
| 1990's | 17 (21.52) | 18.2507 |
| 2000's | 29 (36.71) | 29.6817 |
| 2010's | 18 (22.78) | 24.3611 |
| 2020's | 9 (11.39) | 2.80 |
| Authors | Studies |
|---|---|
| Winstone, JK | 1 |
| Pathak, KV | 1 |
| Winslow, W | 1 |
| Piras, IS | 1 |
| White, J | 1 |
| Sharma, R | 1 |
| Huentelman, MJ | 1 |
| Pirrotte, P | 1 |
| Velazquez, R | 1 |
| Nag, N | 1 |
| Tripathi, T | 1 |
| Uchino, A | 1 |
| Irie, Y | 1 |
| Tsukano, C | 1 |
| Kawase, T | 1 |
| Hirose, K | 1 |
| Kageyama, Y | 1 |
| Tooyama, I | 1 |
| Yanagita, RC | 1 |
| Irie, K | 1 |
| Grasso, G | 1 |
| Leanza, L | 1 |
| Morbiducci, U | 1 |
| Danani, A | 1 |
| Deriu, MA | 1 |
| Egger, F | 1 |
| Jakab, M | 1 |
| Fuchs, J | 1 |
| Oberascher, K | 1 |
| Brachtl, G | 1 |
| Ritter, M | 1 |
| Kerschbaum, HH | 1 |
| Gaisberger, M | 1 |
| Gupta, R | 1 |
| Ambasta, RK | 1 |
| Kumar, P | 1 |
| Darwich, NF | 1 |
| Phan, JM | 1 |
| Kim, B | 1 |
| Suh, E | 1 |
| Papatriantafyllou, JD | 1 |
| Changolkar, L | 1 |
| Nguyen, AT | 1 |
| O'Rourke, CM | 1 |
| He, Z | 1 |
| Porta, S | 1 |
| Gibbons, GS | 1 |
| Luk, KC | 1 |
| Papageorgiou, SG | 1 |
| Grossman, M | 1 |
| Massimo, L | 1 |
| Irwin, DJ | 1 |
| McMillan, CT | 1 |
| Nasrallah, IM | 1 |
| Toro, C | 1 |
| Aguirre, GK | 1 |
| Van Deerlin, VM | 1 |
| Lee, EB | 1 |
| Zhang, X | 1 |
| Ma, X | 1 |
| Gan, T | 1 |
| Shi, Y | 1 |
| Wang, Y | 2 |
| Liu, Q | 1 |
| Nuzzo, T | 1 |
| Mancini, A | 1 |
| Miroballo, M | 1 |
| Casamassa, A | 1 |
| Di Maio, A | 1 |
| Donati, G | 1 |
| Sansone, G | 1 |
| Gaetani, L | 1 |
| Paoletti, FP | 1 |
| Isidori, A | 1 |
| Calabresi, P | 1 |
| Errico, F | 1 |
| Parnetti, L | 1 |
| Usiello, A | 1 |
| Aliès, B | 1 |
| Borghesani, V | 1 |
| Noël, S | 1 |
| Sayen, S | 1 |
| Guillon, E | 1 |
| Testemale, D | 1 |
| Faller, P | 1 |
| Hureau, C | 1 |
| Rosenbrock, H | 1 |
| Desch, M | 1 |
| Kleiner, O | 1 |
| Dorner-Ciossek, C | 1 |
| Schmid, B | 1 |
| Keller, S | 1 |
| Schlecker, C | 1 |
| Moschetti, V | 1 |
| Goetz, S | 1 |
| Liesenfeld, KH | 1 |
| Fillon, G | 1 |
| Giovannini, R | 1 |
| Ramael, S | 1 |
| Wunderlich, G | 1 |
| Wind, S | 1 |
| Battigelli, A | 1 |
| Kenche, VB | 1 |
| Zawisza, I | 1 |
| Masters, CL | 2 |
| Bal, W | 1 |
| Barnham, KJ | 1 |
| Drew, SC | 1 |
| Peters, C | 1 |
| Fernandez-Perez, EJ | 1 |
| Burgos, CF | 1 |
| Espinoza, MP | 1 |
| Castillo, C | 1 |
| Urrutia, JC | 1 |
| Streltsov, VA | 1 |
| Opazo, C | 1 |
| Aguayo, LG | 1 |
| Das, U | 1 |
| Scott, DA | 1 |
| Ganguly, A | 1 |
| Koo, EH | 1 |
| Tang, Y | 1 |
| Roy, S | 1 |
| Timmer, NM | 1 |
| Metaxas, A | 1 |
| van der Stelt, I | 1 |
| Kluijtmans, LA | 1 |
| van Berckel, BN | 1 |
| Verbeek, MM | 1 |
| Lodeiro, M | 1 |
| Ibáñez, C | 1 |
| Cifuentes, A | 1 |
| Simó, C | 1 |
| Cedazo-Mínguez, Á | 1 |
| Roychaudhuri, R | 1 |
| Lomakin, A | 1 |
| Bernstein, S | 1 |
| Zheng, X | 1 |
| Condron, MM | 2 |
| Benedek, GB | 1 |
| Bowers, M | 1 |
| Teplow, DB | 2 |
| Ansoleaga, B | 1 |
| Jové, M | 1 |
| Schlüter, A | 1 |
| Garcia-Esparcia, P | 1 |
| Moreno, J | 1 |
| Pujol, A | 1 |
| Pamplona, R | 1 |
| Portero-Otín, M | 1 |
| Ferrer, I | 1 |
| Marín-Muñoz, J | 1 |
| Noguera-Perea, MF | 1 |
| Gómez-Tortosa, E | 1 |
| López-Motos, D | 1 |
| Antequera-Torres, M | 1 |
| Martínez-Herrada, B | 1 |
| Manzanares-Sánchez, S | 1 |
| Vivancos-Moreau, L | 1 |
| Legaz-García, A | 1 |
| Rábano-Gutiérrez Del Arroyo, A | 1 |
| Antúnez-Almagro, C | 1 |
| Rönnbäck, A | 1 |
| Zhu, S | 1 |
| Dillner, K | 1 |
| Aoki, M | 1 |
| Lilius, L | 1 |
| Näslund, J | 1 |
| Winblad, B | 1 |
| Graff, C | 1 |
| Belarbi, K | 1 |
| Schindowski, K | 1 |
| Burnouf, S | 1 |
| Caillierez, R | 1 |
| Grosjean, ME | 1 |
| Demeyer, D | 1 |
| Hamdane, M | 1 |
| Sergeant, N | 1 |
| Blum, D | 1 |
| Buée, L | 2 |
| Chang, TY | 1 |
| Kuo, HC | 1 |
| Lu, CS | 1 |
| Wu-Chou, YH | 1 |
| Huang, CC | 1 |
| Norton, JB | 1 |
| Cairns, NJ | 2 |
| Chakraverty, S | 1 |
| Wang, J | 1 |
| Levitch, D | 1 |
| Galvin, JE | 1 |
| Goate, A | 1 |
| Yamamoto-Watanabe, Y | 1 |
| Watanabe, M | 1 |
| Jackson, M | 1 |
| Akimoto, H | 1 |
| Sugimoto, K | 1 |
| Yasujima, M | 1 |
| Wakasaya, Y | 1 |
| Matsubara, E | 1 |
| Kawarabayashi, T | 1 |
| Harigaya, Y | 1 |
| Lyndon, AR | 1 |
| Shoji, M | 1 |
| Harun, A | 1 |
| James, RM | 1 |
| Lim, SM | 1 |
| Abdul Majeed, AB | 1 |
| Cole, AL | 1 |
| Ramasamy, K | 1 |
| Tampellini, D | 1 |
| Rahman, N | 1 |
| Lin, MT | 1 |
| Capetillo-Zarate, E | 1 |
| Gouras, GK | 1 |
| Wu, H | 1 |
| Li, J | 1 |
| Zhang, Q | 1 |
| Yan, X | 1 |
| Guo, L | 1 |
| Gao, X | 1 |
| Qiu, M | 1 |
| Jiang, X | 1 |
| Lai, R | 1 |
| Chen, H | 1 |
| Oyatsi, F | 1 |
| Whiteley, CG | 1 |
| García-Lozano, JR | 1 |
| Mir, P | 1 |
| Alberca, R | 1 |
| Aguilera, I | 1 |
| Gil Néciga, E | 1 |
| Fernández-López, O | 1 |
| Cayuela, A | 1 |
| Núñez-Roldan, A | 1 |
| Brunelle, P | 1 |
| Rauk, A | 1 |
| Pola, R | 1 |
| Gaetani, E | 1 |
| Flex, A | 1 |
| Gerardino, L | 1 |
| Aloi, F | 1 |
| Flore, R | 1 |
| Serricchio, M | 1 |
| Pola, P | 1 |
| Bernabei, R | 1 |
| Culpan, D | 1 |
| MacGowan, SH | 1 |
| Ford, JM | 1 |
| Nicoll, JA | 1 |
| Griffin, WS | 1 |
| Dewar, D | 1 |
| Hughes, A | 1 |
| Kehoe, PG | 1 |
| Wilcock, GK | 1 |
| Hovinga, CA | 1 |
| Zekanowski, C | 1 |
| Pepłońska, B | 1 |
| Styczyńska, M | 1 |
| Religa, D | 1 |
| Pfeffer, A | 1 |
| Czyzewski, K | 1 |
| Gabryelewicz, T | 1 |
| Szybińska, A | 1 |
| Kijanowska-Haładyna, B | 1 |
| Kotapka-Minc, S | 1 |
| Łuczywek, E | 1 |
| Barczak, A | 1 |
| Wasiak, B | 1 |
| Chodakowska-Zebrowska, M | 1 |
| Przekop, I | 1 |
| Kuźnicki, J | 1 |
| Barcikowska, M | 1 |
| Orlacchio, A | 2 |
| Kawarai, T | 2 |
| Polidoro, M | 1 |
| Paterson, AD | 1 |
| Rogaeva, E | 2 |
| St George-Hyslop, PH | 1 |
| Bernardi, G | 1 |
| Doran, M | 1 |
| Larner, AJ | 1 |
| Helisalmi, S | 1 |
| Hiltunen, M | 1 |
| Vepsäläinen, S | 1 |
| Iivonen, S | 1 |
| Corder, EH | 1 |
| Lehtovirta, M | 1 |
| Mannermaa, A | 1 |
| Koivisto, AM | 1 |
| Soininen, H | 1 |
| Benaki, D | 2 |
| Zikos, C | 2 |
| Evangelou, A | 2 |
| Livaniou, E | 2 |
| Vlassi, M | 2 |
| Mikros, E | 2 |
| Pelecanou, M | 2 |
| Zabetian, CP | 1 |
| Lauricella, CJ | 1 |
| Tsuang, DW | 1 |
| Leverenz, JB | 1 |
| Schellenberg, GD | 1 |
| Payami, H | 1 |
| Aikoh, H | 1 |
| Nakamura, K | 1 |
| Yamato, M | 1 |
| Shibahara, T | 1 |
| Arakawa, T | 1 |
| Niikura, T | 1 |
| Tajima, H | 1 |
| Kita, Y | 1 |
| Albani, D | 1 |
| Roiter, I | 1 |
| Artuso, V | 1 |
| Batelli, S | 1 |
| Prato, F | 1 |
| Pesaresi, M | 1 |
| Galimberti, D | 1 |
| Scarpini, E | 1 |
| Bruni, A | 1 |
| Franceschi, M | 1 |
| Piras, MR | 1 |
| Confaloni, A | 1 |
| Forloni, G | 1 |
| Zhao, X | 1 |
| Marszalec, W | 1 |
| Toth, PT | 1 |
| Huang, J | 1 |
| Yeh, JZ | 1 |
| Narahashi, T | 1 |
| Rauscher, S | 1 |
| Baud, S | 1 |
| Miao, M | 1 |
| Keeley, FW | 1 |
| Pomès, R | 1 |
| Reis, K | 1 |
| Zharkovsky, A | 1 |
| Bogdanovic, N | 1 |
| Karelson, E | 1 |
| Land, T | 1 |
| Tumini, E | 1 |
| Porcellini, E | 1 |
| Chiappelli, M | 1 |
| Conti, CM | 1 |
| Beraudi, A | 1 |
| Poli, A | 1 |
| Caciagli, F | 1 |
| Doyle, R | 1 |
| Conti, P | 1 |
| Licastro, F | 1 |
| Tsang, SW | 1 |
| Vinters, HV | 1 |
| Cummings, JL | 1 |
| Wong, PT | 1 |
| Chen, CP | 2 |
| Lai, MK | 1 |
| Tan, EK | 1 |
| Lee, J | 1 |
| Wong, MC | 1 |
| Zhao, Y | 1 |
| Pomara, N | 1 |
| Banay-Schwartz, M | 1 |
| Block, R | 1 |
| Stanley, M | 1 |
| Gershon, S | 1 |
| Boatell, ML | 1 |
| Bendahan, G | 1 |
| Mahy, N | 1 |
| Clements, A | 1 |
| Walsh, DM | 2 |
| Williams, CH | 1 |
| Allsop, D | 1 |
| Dudek, SM | 1 |
| Johnson, GV | 1 |
| Rossor, MN | 1 |
| Newman, S | 2 |
| Frackowiak, RS | 2 |
| Lantos, P | 1 |
| Kennedy, AM | 2 |
| Palmer, AM | 2 |
| Burns, MA | 1 |
| Ding, W | 1 |
| Delacourte, A | 1 |
| Fillit, H | 1 |
| McCaddon, A | 1 |
| Ball, J | 1 |
| Roques, P | 1 |
| Mullan, M | 1 |
| Hardy, J | 1 |
| Chartier-Harlin, MC | 1 |
| Warrington, EK | 1 |
| Rosenberg, RN | 1 |
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| Stirling, JM | 1 |
| Cross, AJ | 1 |
| Vamvakides, A | 1 |
| Smith, CC | 1 |
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8 reviews available for glycine and Acute Confusional Senile Dementia
| Article | Year |
|---|---|
Tau-FG-nucleoporin98 interaction and impaired nucleocytoplasmic transport in Alzheimer's disease.
Topics: Active Transport, Cell Nucleus; Alzheimer Disease; Glycine; Humans; Nuclear Pore; Nuclear Pore Compl | 2023 |
Design and preparation of organic nanomaterials using self-assembled peptoids.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Catalysis; Drug Carriers; Glycine; Humans; Nanostructures; | 2019 |
Valrocemide (Teva/Acorda).
Topics: Alzheimer Disease; Animals; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; G | 2004 |
Alzheimer's disease families with amyloid precursor protein mutations.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Protein Precursor; Brain; Glycine; Humans; Isol | 1993 |
A causal role for amyloid in Alzheimer's disease: the end of the beginning.
Topics: Alanine; Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Amyloid beta-Protein Precurs | 1993 |
The glycine site on the NMDA receptor: structure-activity relationships and possible therapeutic applications.
Topics: Alzheimer Disease; Animals; Binding Sites; Cerebrovascular Disorders; Epilepsy; Glycine; Humans; Neu | 1998 |
(S)-3,5-DHPG: a review.
Topics: Action Potentials; Alzheimer Disease; Animals; Behavior, Animal; Cognition Disorders; Cyclic AMP; Ex | 2002 |
[Working hypothesis for the pharmacologic research in the glutamatergic approach to Alzheimer's disease].
Topics: Alzheimer Disease; Animals; Glutamates; Glutamic Acid; Glycine; Lactones | 1989 |
2 trials available for glycine and Acute Confusional Senile Dementia
| Article | Year |
|---|---|
Evaluation of Pharmacokinetics and Pharmacodynamics of BI 425809, a Novel GlyT1 Inhibitor: Translational Studies.
Topics: Administration, Oral; Adult; Alzheimer Disease; Animals; Area Under Curve; Cell Line; Dose-Response | 2018 |
Improved cognition in Alzheimer's disease with short-term D-cycloserine treatment.
Topics: Aged; Alzheimer Disease; Cognition; Cognition Disorders; Cycloserine; Dose-Response Relationship, Dr | 1999 |
69 other studies available for glycine and Acute Confusional Senile Dementia
| Article | Year |
|---|---|
Glyphosate infiltrates the brain and increases pro-inflammatory cytokine TNFα: implications for neurodegenerative disorders.
Topics: Alzheimer Disease; Animals; Brain; Chromatography, Liquid; Cytokines; Glycine; Glyphosate; Herbicide | 2022 |
Synthesis and Characterization of Propeller- and Parallel-Type Full-Length Amyloid β40 Trimer Models.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Glycine; Humans; Neuroblastoma; Peptide Fragments | 2022 |
Aminoacid substitutions in the glycine zipper affect the conformational stability of amyloid beta fibrils.
Topics: Alzheimer Disease; Amino Acid Substitution; Amyloid; Amyloid beta-Peptides; Glycine; Humans; Molecul | 2020 |
Effect of Glycine on BV-2 Microglial Cells Treated with Interferon-γ and Lipopolysaccharide.
Topics: Alzheimer Disease; Animals; Antigens, CD; Apoptosis; Cell Line, Transformed; Glutathione; Glycine; H | 2020 |
Identification of novel class I and class IIb histone deacetylase inhibitor for Alzheimer's disease therapeutics.
Topics: Alzheimer Disease; Aspartic Acid; Databases, Chemical; Drug Evaluation, Preclinical; Glycine; Histon | 2020 |
Autosomal dominant VCP hypomorph mutation impairs disaggregation of PHF-tau.
Topics: Alzheimer Disease; Animals; Aspartic Acid; Gene Knock-In Techniques; Genes, Dominant; Glycine; Human | 2020 |
Secondary Chemical Bonding between Insoluble Calcium Oxalate and Carbonyl Oxygen Atoms of GLY and VAL Residues Triggers the Formation of Aβ Aggregates and Their Deposition in the Brain.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Brain; Calcium Oxalate; Glycine; Humans; Oxygen; Valine | 2020 |
High performance liquid chromatography determination of L-glutamate, L-glutamine and glycine content in brain, cerebrospinal fluid and blood serum of patients affected by Alzheimer's disease.
Topics: Aged, 80 and over; Alzheimer Disease; Biomarkers; Chromatography, High Pressure Liquid; Female; Glut | 2021 |
Mutations of Histidine 13 to Arginine and Arginine 5 to Glycine Are Responsible for Different Coordination Sites of Zinc(II) to Human and Murine Peptides.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Arginine; Binding Sites; Coordination Complexes; | 2018 |
Mixed ligand Cu2+ complexes of a model therapeutic with Alzheimer's amyloid-β peptide and monoamine neurotransmitters.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Copper; Glutamic Acid; Glutathione Disulfide; Glycine; His | 2013 |
Inhibition of amyloid beta-induced synaptotoxicity by a pentapeptide derived from the glycine zipper region of the neurotoxic peptide.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Brain; Calcium; Cell Membrane; Cells, Cultured; Glycine; H | 2013 |
Activity-induced convergence of APP and BACE-1 in acidic microdomains via an endocytosis-dependent pathway.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; An | 2013 |
Cerebral level of vGlut1 is increased and level of glycine is decreased in TgSwDI mice.
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Autoradiog | 2014 |
Decreased cerebrospinal fluid levels of L-carnitine in non-apolipoprotein E4 carriers at early stages of Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Apolipoprotein E4; Arginine; Biomarkers; Carnitine; | 2014 |
Gly25-Ser26 amyloid β-protein structural isomorphs produce distinct Aβ42 conformational dynamics and assembly characteristics.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Biophysical Phenomena; Click Chemistry; Glycine; Humans; M | 2014 |
Deregulation of purine metabolism in Alzheimer's disease.
Topics: Adenosine Triphosphatases; Adenylate Kinase; Aged; Aged, 80 and over; Alzheimer Disease; Chromatogra | 2015 |
Novel Mutation (Gly212Val) in the PS2 Gene Associated with Early-Onset Familial Alzheimer's Disease.
Topics: Age of Onset; Aged; Alzheimer Disease; DNA Mutational Analysis; Family Health; Female; Glycine; Huma | 2016 |
Progressive neuropathology and cognitive decline in a single Arctic APP transgenic mouse model.
Topics: Age Factors; Alanine; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Anim | 2011 |
Early Tau pathology involving the septo-hippocampal pathway in a Tau transgenic model: relevance to Alzheimer's disease.
Topics: Age Factors; Alzheimer Disease; Animals; Brain Mapping; Disease Models, Animal; Glycine; Hippocampus | 2009 |
Analysis of the LRRK2 Gly2385Arg variant in Alzheimer's disease in Taiwan.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Arginine; DNA Mutational Analysis; Female; Gene Frequenc | 2010 |
Presenilin1 G217R mutation linked to Alzheimer disease with cotton wool plaques.
Topics: Alzheimer Disease; Amino Acid Substitution; Amyloid beta-Peptides; Arginine; Female; Genetic Linkage | 2009 |
Quantification of cystatin C in cerebrospinal fluid from various neurological disorders and correlation with G73A polymorphism in CST3.
Topics: Aged; Aged, 80 and over; Alanine; Alzheimer Disease; Amyotrophic Lateral Sclerosis; Biomarkers; Case | 2010 |
BACE1 inhibitory activity of fungal endophytic extracts from Malaysian medicinal plants.
Topics: Alzheimer Disease; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Biol | 2011 |
Impaired β-amyloid secretion in Alzheimer's disease pathogenesis.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Calcium-Calmoduli | 2011 |
A novel small Odorranalectin-bearing cubosomes: preparation, brain delivery and pharmacodynamic study on amyloid-β₂₅₋₃₅-treated rats following intranasal administration.
Topics: Administration, Intranasal; Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Coumarins; Dis | 2012 |
Interaction of superoxide dismutase with the glycine zipper regions of β-amyloid peptides: is there an implication towards Alzheimer's disease and oxidative stress?
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Cattle; Dose-Response Relationship, Drug; | 2013 |
Mitochondrial DNA A4336G mutation in Alzheimer's and Parkinson's diseases.
Topics: Aged; Alanine; Alzheimer Disease; Case-Control Studies; DNA, Mitochondrial; Female; Glycine; Humans; | 2002 |
The radical model of Alzheimer's disease: specific recognition of Gly29 and Gly33 by Met35 in a beta-sheet model of Abeta: an ONIOM study.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Cell Membrane; Free Radicals; Glycine; Humans; Hydrogen Pe | 2002 |
Lack of association between Alzheimer's disease and Gln-Arg 192 Q/R polymorphism of the PON-1 gene in an Italian population.
Topics: Aged; Alzheimer Disease; Amino Acid Substitution; Arginine; Aryldialkylphosphatase; Case-Control Stu | 2003 |
Tumour necrosis factor-alpha gene polymorphisms and Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alanine; Alleles; Alzheimer Disease; Case-Control Studies; Cohort Studies; | 2003 |
The E318G substitution in PSEN1 gene is not connected with Alzheimer's disease in a large Polish cohort.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Case-Control Studies; Chi-Square Distribution; Cohort St | 2004 |
Lack of association between Alzheimer's disease and the promoter region polymorphisms of the nicastrin gene.
Topics: Adult; Age of Onset; Aged; Alanine; Alleles; Alzheimer Disease; Amyloid Precursor Protein Secretases | 2004 |
Prominent behavioural and psychiatric symptoms in early-onset Alzheimer's disease in a sib pair with the presenilin-1 gene R269G mutation.
Topics: Alzheimer Disease; Arginine; DNA Mutational Analysis; Family Health; Female; Glycine; Humans; Male; | 2004 |
Genetic variation in apolipoprotein D and Alzheimer's disease.
Topics: Age of Onset; Aged; Alanine; Alzheimer Disease; Apolipoproteins; Apolipoproteins D; Case-Control Stu | 2004 |
Solution structure of humanin, a peptide against Alzheimer's disease-related neurotoxicity.
Topics: Alzheimer Disease; Circular Dichroism; Glutamic Acid; Glycine; Humans; Intracellular Signaling Pepti | 2005 |
Analysis of the LRRK2 G2019S mutation in Alzheimer Disease.
Topics: Aged; Alzheimer Disease; DNA Mutational Analysis; Female; Glycine; Humans; Leucine-Rich Repeat Serin | 2006 |
Studies on the amount of aluminum and calcium in urine following aluminum administration with and without amino acids.
Topics: Aluminum; Alzheimer Disease; Amino Acids; Animals; Calcium; Glutamic Acid; Glycine; Mice; Neurotoxin | 2005 |
The secondary structure analysis of a potent Ser14Gly analog of antiAlzheimer peptide, Humanin, by circular dichroism.
Topics: Alzheimer Disease; Circular Dichroism; Glycine; Humans; Hydrophobic and Hydrophilic Interactions; In | 2006 |
Solution structure of Ser14Gly-humanin, a potent rescue factor against neuronal cell death in Alzheimer's disease.
Topics: Alzheimer Disease; Amino Acid Sequence; Apoptosis; Base Sequence; Circular Dichroism; Glycine; Human | 2006 |
Presenilin-1 mutation E318G and familial Alzheimer's disease in the Italian population.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amino Acid Substitution; Case-Control Studies; Female; G | 2007 |
In vitro galantamine-memantine co-application: mechanism of beneficial action.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolep | 2006 |
Proline and glycine control protein self-organization into elastomeric or amyloid fibrils.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid; Animals; Benzothiazoles; Chickens; Elastin; Entropy | 2006 |
Critical role of methionine-722 in the stimulation of human brain G-proteins and neurotoxicity induced by London familial Alzheimer's disease (FAD) mutated V717G-APP(714-723).
Topics: Aged; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Case-Control Studies; Cell Differe | 2007 |
The G51S purine nucleoside phosphorylase polymorphism is associated with cognitive decline in Alzheimer's disease patients.
Topics: Alleles; Alzheimer Disease; Apolipoprotein E4; Cognition Disorders; Disease Progression; Follow-Up S | 2007 |
Alterations in NMDA receptor subunit densities and ligand binding to glycine recognition sites are associated with chronic anxiety in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Anxiety Disorders; Binding, Competitive; Brain; Chronic | 2008 |
Case control analysis of LRRK2 Gly2385Arg in Alzheimer's disease.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Amino Acid Substitution; Arginine; Case-Control S | 2009 |
Elevation of RBC glycine and choline levels in geriatric patients treated with lithium.
Topics: Aged; Alzheimer Disease; Choline; Cognition Disorders; Dementia; Erythrocytes; Female; Glycine; Huma | 1983 |
Time-related cortical amino acid changes after basal forebrain lesion: a microdialysis study.
Topics: Alzheimer Disease; Amino Acids; Animals; Brain Diseases; Cerebral Cortex; Chromatography, High Press | 1995 |
Effects of the mutations Glu22 to Gln and Ala21 to Gly on the aggregation of a synthetic fragment of the Alzheimer's amyloid beta/A4 peptide.
Topics: Alanine; Alzheimer Disease; Amino Acid Sequence; Amyloid; Amyloid beta-Peptides; Glutamates; Glutami | 1993 |
Transglutaminase facilitates the formation of polymers of the beta-amyloid peptide.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloidosis; Glycine; Humans; Lysine; Mutation; Transgluta | 1994 |
Preservation of redox, polyamine, and glycine modulatory domains of the N-methyl-D-aspartate receptor in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Biguanides; Binding Sites; Brain; | 1994 |
Binding of secreted human neuroblastoma proteoglycans to the Alzheimer's amyloid A4 peptide.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Antibodies, Monoclonal; Chondroitin Lyases; Chromatography | 1993 |
Familial Alzheimer's disease. A pedigree with a mis-sense mutation in the amyloid precursor protein gene (amyloid precursor protein 717 valine-->glycine).
Topics: Adult; Aged; Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Protein Precursor; Female; Glycine | 1993 |
Possible association of missense mutation (Gly[-63]Glu) of the neurotrophin-3 gene with Alzheimer's disease in Japanese.
Topics: Adult; Aged; Aged, 80 and over; Alleles; Alzheimer Disease; Amino Acid Substitution; Female; Genetic | 1998 |
D-cycloserine, a partial NMDA receptor-associated glycine-B site agonist, enhances reversal learning, but a cholinesterase inhibitor and nicotine has no effect.
Topics: Alzheimer Disease; Animals; Antimetabolites; Binding Sites; Cholinesterase Inhibitors; Conditioning, | 1998 |
ATP nucleotidylation of creatine kinase.
Topics: Adenosine Triphosphate; Alzheimer Disease; Animals; Azides; Brain Chemistry; Chromatography, High Pr | 1999 |
In vitro studies of amyloid beta-protein fibril assembly and toxicity provide clues to the aetiology of Flemish variant (Ala692-->Gly) Alzheimer's disease.
Topics: Alanine; Alzheimer Disease; Amino Acid Substitution; Amyloid beta-Peptides; Animals; Cells, Cultured | 2001 |
Huperzine A, a nootropic alkaloid, inhibits N-methyl-D-aspartate-induced current in rat dissociated hippocampal neurons.
Topics: Alkaloids; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Alzheimer Disease; Animals; Cel | 2001 |
A founder mutation in presenilin 1 causing early-onset Alzheimer disease in unrelated Caribbean Hispanic families.
Topics: Age of Onset; Aged; Alanine; Alzheimer Disease; Amyloid beta-Protein Precursor; Apolipoproteins E; C | 2001 |
Contrasting, species-dependent modulation of copper-mediated neurotoxicity by the Alzheimer's disease amyloid precursor protein.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Binding Sites; Caenorhabditis elegans; C | 2002 |
Spermidine antagonizes the inhibitory effect of huperzine A on [3H]dizocilpine (MK-801) binding in synaptic membrane of rat cerebral cortex.
Topics: Alkaloids; Alzheimer Disease; Animals; Binding Sites; Binding, Competitive; Cerebral Cortex; Choline | 2002 |
Tau pathology in a case of familial Alzheimer's disease with a valine to glycine mutation at position 717 in the amyloid precursor protein.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Antibodies, Monoclonal; Blotting, Western; Electr | 1992 |
Characterisation of the glycine modulatory site of the N-methyl-D-aspartate receptor-ionophore complex in human brain.
Topics: Aged; Aged, 80 and over; Allosteric Site; Alzheimer Disease; Animals; Cell Membrane; Cerebral Cortex | 1991 |
L-phosphoserine, a metabolite elevated in Alzheimer's disease, interacts with specific L-glutamate receptor subtypes.
Topics: 2-Amino-5-phosphonovalerate; Alzheimer Disease; Animals; Dizocilpine Maleate; Dose-Response Relation | 1991 |
Binding to the glycine site of the NMDA receptor complex in brains of patients with Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Autoradiography; Brain; Caudate Nucleus; Cell Membrane; Cerebral Cortex; Gl | 1991 |
The N-methyl-D-aspartate receptor complex in Alzheimer's disease: reduced regulation by glycine but not zinc.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Brain; Dibenzocycloheptenes; Dizocilpine Maleate; Female | 1989 |
Reduced glycine stimulation of [3H]MK-801 binding in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Brain; Cell Membrane; Cerebellar Cortex; Dibenzocyclohep | 1989 |
Loss of glycine-dependent radioligand binding to the N-methyl-D-aspartate-phencyclidine receptor complex in patients with Alzheimer's disease.
Topics: Alzheimer Disease; Glutamates; Glutamic Acid; Glycine; Humans; Kinetics; Radioligand Assay; Receptor | 1989 |
Putative amino acid transmitters in lumbar cerebrospinal fluid of patients with histologically verified Alzheimer's dementia.
Topics: Adult; Aged; Alzheimer Disease; Amino Acids; Aspartic Acid; Dementia; Epilepsy; Female; Glutamates; | 1985 |