Page last updated: 2024-08-21

glycerylphosphorylcholine and Alzheimer Disease

glycerylphosphorylcholine has been researched along with Alzheimer Disease in 18 studies

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19901 (5.56)18.7374
1990's4 (22.22)18.2507
2000's3 (16.67)29.6817
2010's6 (33.33)24.3611
2020's4 (22.22)2.80

Authors

AuthorsStudies
Chang, J; Choi, D; Choi, S; Jeong, S; Kim, K; Kim, SM; Lee, G; Park, SM; Son, JS1
Androsova, LV; Gavrilova, SI; Kolykhalov, IV1
Alfonsetti, M; Antonosante, A; Benedetti, E; Castelli, V; Catanesi, M; Cimini, A; d'Angelo, M; Desideri, G; Ferri, C1
Bernardini, R; Burgaletto, C; Cantarella, G; Di Benedetto, G; Munafò, A1
Amenta, F; Carotenuto, A; Fasanaro, AM; Rea, R; Traini, E2
Amenta, F; Carotenuto, A; Fasanaro, AM; Manzo, V; Rea, R; Traini, E1
Amenta, F; Carotenuto, A; Fasanaro, AM; Manzo, V; Rea, R; Ricci, G; Traini, E1
Chan, A; Shea, TB; Suchy, J1
Forster, DM; James, MF; Williams, SR1
Amenta, F; Tayebati, SK1
De Jesus Moreno Moreno, M1
Bodick, N; Offen, WW; Renshaw, PF; Satlin, A1
Blusztajn, JK; Farber, SA; Slack, BE1
Blusztajn, JK; Growdon, JH; Nitsch, RM; Pittas, AG; Slack, BE; Wurtman, RJ1
Blusztajn, JK; Growdon, JH; Nitsch, R; Pittas, A; Slack, BE; Wurtman, RJ1
Blusztajn, JK; Growdon, JH; Logue, M; Lopez Gonzalez-Coviella, I; Wurtman, RJ1
Arús, C; Bárány, M; Chang, YC; Frey, WH; Rustan, T1

Reviews

1 review(s) available for glycerylphosphorylcholine and Alzheimer Disease

ArticleYear
Choline-containing phospholipids: relevance to brain functional pathways.
    Clinical chemistry and laboratory medicine, 2013, Mar-01, Volume: 51, Issue:3

    Topics: Acetylcholine; Alzheimer Disease; Animals; Brain; Choline; Cholinergic Neurons; Glycerylphosphorylcholine; Humans; Neurodegenerative Diseases; Neuroglia; Phospholipids

2013

Trials

6 trial(s) available for glycerylphosphorylcholine and Alzheimer Disease

ArticleYear
The ASCOMALVA (Association between the Cholinesterase Inhibitor Donepezil and the Cholinergic Precursor Choline Alphoscerate in Alzheimer's Disease) Trial: interim results after two years of treatment.
    Journal of Alzheimer's disease : JAD, 2014, Volume: 42 Suppl 3

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Antipsychotic Agents; Donepezil; Double-Blind Method; Female; Glycerylphosphorylcholine; Humans; Indans; Longitudinal Studies; Male; Mental Status Schedule; Middle Aged; Piperidines; Severity of Illness Index

2014
Apathy Treatment in Alzheimer's Disease: Interim Results of the ASCOMALVA Trial.
    Journal of Alzheimer's disease : JAD, 2015, Volume: 48, Issue:2

    Topics: Aged; Alzheimer Disease; Apathy; Caregivers; Cholinergic Agents; Donepezil; Double-Blind Method; Drug Therapy, Combination; Female; Glycerylphosphorylcholine; Humans; Indans; Male; Piperidines; Psychiatric Status Rating Scales; Psychotropic Drugs; Time Factors; Treatment Outcome

2015
The Effect of the Association between Donepezil and Choline Alphoscerate on Behavioral Disturbances in Alzheimer's Disease: Interim Results of the ASCOMALVA Trial.
    Journal of Alzheimer's disease : JAD, 2017, Volume: 56, Issue:2

    Topics: Aged; Alzheimer Disease; Anxiety; Apathy; Caregivers; Depression; Donepezil; Double-Blind Method; Female; Glycerylphosphorylcholine; Humans; Indans; Male; Piperidines; Psychotropic Drugs; Severity of Illness Index; Stress, Psychological; Treatment Outcome

2017
The ASCOMALVA trial: association between the cholinesterase inhibitor donepezil and the cholinergic precursor choline alphoscerate in Alzheimer's disease with cerebrovascular injury: interim results.
    Journal of the neurological sciences, 2012, Nov-15, Volume: 322, Issue:1-2

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cerebrovascular Disorders; Donepezil; Double-Blind Method; Female; Follow-Up Studies; Glycerylphosphorylcholine; Humans; Indans; Male; Mental Status Schedule; Middle Aged; Nootropic Agents; Piperidines; Treatment Outcome

2012
Cognitive improvement in mild to moderate Alzheimer's dementia after treatment with the acetylcholine precursor choline alfoscerate: a multicenter, double-blind, randomized, placebo-controlled trial.
    Clinical therapeutics, 2003, Volume: 25, Issue:1

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinergic Agents; Cognition; Double-Blind Method; Female; Glycerylphosphorylcholine; Humans; Male; Mental Status Schedule; Middle Aged; Treatment Outcome

2003
Brain proton magnetic resonance spectroscopy (1H-MRS) in Alzheimer's disease: changes after treatment with xanomeline, an M1 selective cholinergic agonist.
    The American journal of psychiatry, 1997, Volume: 154, Issue:10

    Topics: Acetylcholine; Alzheimer Disease; Brain; Choline; Creatine; Dose-Response Relationship, Drug; Drug Administration Schedule; Frontal Lobe; Glycerylphosphorylcholine; Humans; Magnetic Resonance Spectroscopy; Muscarinic Antagonists; Neurons; Parasympathetic Nervous System; Protons; Pyridines; Thiadiazoles

1997

Other Studies

11 other study(ies) available for glycerylphosphorylcholine and Alzheimer Disease

ArticleYear
Association of L-α Glycerylphosphorylcholine With Subsequent Stroke Risk After 10 Years.
    JAMA network open, 2021, 11-01, Volume: 4, Issue:11

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Biological Monitoring; Cohort Studies; Female; Glycerylphosphorylcholine; Humans; Male; Middle Aged; Proportional Hazards Models; Republic of Korea; Retrospective Studies; Risk Assessment; Risk Factors; Stroke

2021
[Clinical and immunological effects of choline alfoscerate in the treatment of amnestic type Mild Cognitive Impairment].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2022, Volume: 122, Issue:11. Vyp. 2

    Topics: Aged; Alzheimer Disease; Cognition; Cognitive Dysfunction; Glycerylphosphorylcholine; Humans; Middle Aged; Neuropsychological Tests

2022
Neuroprotective potential of choline alfoscerate against β-amyloid injury: Involvement of neurotrophic signals.
    Cell biology international, 2020, Volume: 44, Issue:8

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Apoptosis; Brain-Derived Neurotrophic Factor; Cell Differentiation; Cell Line, Tumor; Cell Survival; Glycerylphosphorylcholine; Humans; Neurons; Neuroprotective Agents; Peptide Fragments; Receptor, trkB; Signal Transduction

2020
Beneficial Effects of Choline Alphoscerate on Amyloid-β Neurotoxicity in an In vitro Model of Alzheimer's Disease.
    Current Alzheimer research, 2021, Volume: 18, Issue:4

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cell Differentiation; Glycerylphosphorylcholine; Humans; In Vitro Techniques; Mice; Neurons; Peptide Fragments; Phosphorylation; tau Proteins

2021
Dietary supplementation with a combination of alpha-lipoic acid, acetyl-L-carnitine, glycerophosphocoline, docosahexaenoic acid, and phosphatidylserine reduces oxidative damage to murine brain and improves cognitive performance.
    Nutrition research (New York, N.Y.), 2009, Volume: 29, Issue:1

    Topics: Acetylcarnitine; Alzheimer Disease; Animals; Antioxidants; Apolipoproteins E; Cognition Disorders; Dietary Supplements; Docosahexaenoic Acids; Drug Therapy, Combination; Folic Acid Deficiency; Glycerylphosphorylcholine; Iron; Maze Learning; Mice; Mice, Knockout; Nootropic Agents; Oxidative Stress; Phosphatidylserines; Reactive Oxygen Species; Thioctic Acid; Vitamin E Deficiency

2009
Effects of Alzheimer's disease transgenes on neurochemical expression in the mouse brain determined by ¹H MRS in vitro.
    NMR in biomedicine, 2012, Volume: 25, Issue:1

    Topics: Alzheimer Disease; Analysis of Variance; Animals; Aspartic Acid; Biomarkers; Brain; Choline; Glycerylphosphorylcholine; Humans; Inositol; Magnetic Resonance Spectroscopy; Mice; Mice, Transgenic; Transgenes

2012
Acceleration of phosphatidylcholine synthesis and breakdown by inhibitors of mitochondrial function in neuronal cells: a model of the membrane defect of Alzheimer's disease.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2000, Volume: 14, Issue:14

    Topics: Alzheimer Disease; Animals; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Choline; Cytidine Diphosphate Choline; Dinitrophenols; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glycerylphosphorylcholine; Membranes; Mitochondria; Neurons; PC12 Cells; Phosphatidylcholines; Phosphorylcholine; Rats; Sodium Azide; Time Factors; Uncoupling Agents

2000
Evidence for a membrane defect in Alzheimer disease brain.
    Proceedings of the National Academy of Sciences of the United States of America, 1992, Mar-01, Volume: 89, Issue:5

    Topics: Aged; Alzheimer Disease; Brain; Brain Chemistry; Choline; Down Syndrome; Glycerylphosphorylcholine; Humans; Huntington Disease; Membrane Lipids; Middle Aged; Parkinson Disease; Phospholipids; Phosphoric Diester Hydrolases; Phosphorylcholine

1992
Alterations of phospholipid metabolites in postmortem brain from patients with Alzheimer's disease.
    Annals of the New York Academy of Sciences, 1991, Volume: 640

    Topics: Alzheimer Disease; Brain; Glycerylphosphorylcholine; Humans; Phosphatidylethanolamines; Phosphoric Diester Hydrolases

1991
Levels of phospholipid catabolic intermediates, glycerophosphocholine and glycerophosphoethanolamine, are elevated in brains of Alzheimer's disease but not of Down's syndrome patients.
    Brain research, 1990, Dec-17, Volume: 536, Issue:1-2

    Topics: Aged; Alzheimer Disease; Brain; Down Syndrome; Female; Glycerylphosphorylcholine; Humans; Male; Middle Aged; Nerve Degeneration; Phosphatidylethanolamines

1990
Increased glycerol-3-phosphorylcholine in post-mortem Alzheimer's brain.
    Lancet (London, England), 1985, Mar-02, Volume: 1, Issue:8427

    Topics: Alzheimer Disease; Brain Chemistry; Glycerylphosphorylcholine; Humans; Magnetic Resonance Spectroscopy

1985