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glycerol and Infarction, Middle Cerebral Artery

glycerol has been researched along with Infarction, Middle Cerebral Artery in 16 studies

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Infarction, Middle Cerebral Artery: NECROSIS occurring in the MIDDLE CEREBRAL ARTERY distribution system which brings blood to the entire lateral aspects of each CEREBRAL HEMISPHERE. Clinical signs include impaired cognition; APHASIA; AGRAPHIA; weak and numbness in the face and arms, contralaterally or bilaterally depending on the infarction.

Research Excerpts

ExcerptRelevanceReference
"Osmotic agents such as glycerol are used to treat brain edema in stroke patients."7.73Neurochemical monitoring of glycerol therapy in patients with ischemic brain edema. ( Berger, C; Kiening, KL; Sakowitz, OW; Schwab, S, 2005)
"Despite its significance, present treatment for brain edema simply provides symptomatic relief due to the fact that molecular mechanisms underlying brain edema remain poorly understood."5.37Hypoxia-inducible factor-1α contributes to brain edema after stroke by regulating aquaporins and glycerol distribution in brain. ( Ding, Y; Dornbos, D; Guthikonda, M; Higashida, T; Kinni, H; Li, J; Li, X; Peng, C; Teng, K, 2011)
"Osmotic agents such as glycerol are used to treat brain edema in stroke patients."3.73Neurochemical monitoring of glycerol therapy in patients with ischemic brain edema. ( Berger, C; Kiening, KL; Sakowitz, OW; Schwab, S, 2005)
"Despite its significance, present treatment for brain edema simply provides symptomatic relief due to the fact that molecular mechanisms underlying brain edema remain poorly understood."1.37Hypoxia-inducible factor-1α contributes to brain edema after stroke by regulating aquaporins and glycerol distribution in brain. ( Ding, Y; Dornbos, D; Guthikonda, M; Higashida, T; Kinni, H; Li, J; Li, X; Peng, C; Teng, K, 2011)
"Glycerol concentration was significantly lower in patients treated by hypothermia (111 +/- 17 micromol/l; P < 0."1.35Neurochemical monitoring of therapeutic effects in large human MCA infarction. ( Berger, C; Kiening, K; Schwab, S, 2008)
"Glycerol (4 g/kg) suppressed the cerebral edema but did not reduce the size of cerebral infarction in the cerebral cortex or striatum."1.31Effective plasma concentration of a novel Na+/Ca2+ channel blocker NS-7 for its cerebroprotective actions in rats with a transient middle cerebral artery occlusion. ( Aoki, Y; Itoh, Y; Mukai, H; Nonaka, K; Seto, T; Tamura, M; Ukai, Y, 2001)
"Transorbital 2 hour middle cerebral artery occlusion (MCAO) was performed in eight monkeys, which were studied with continuous microdialysis for 24 hours."1.31Increase of interstitial glycerol reflects the degree of ischaemic brain damage: a PET and microdialysis study in a middle cerebral artery occlusion-reperfusion primate model. ( Enblad, P; Frykholm, P; Hillered, L; Långström, B; Persson, L; Valtysson, J; Watanabe, Y, 2001)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (6.25)18.2507
2000's10 (62.50)29.6817
2010's4 (25.00)24.3611
2020's1 (6.25)2.80

Authors

AuthorsStudies
Honore, PM1
Redant, S1
Preseau, T1
Moorthamers, S1
Kaefer, K1
Gutierrez, LB1
Attou, R1
Gallerani, A1
De Bels, D1
Arikan, F1
Martínez-Valverde, T1
Sánchez-Guerrero, Á1
Campos, M1
Esteves, M1
Gandara, D1
Torné, R1
Castro, L1
Dalmau, A1
Tibau, J1
Sahuquillo, J1
Kiewert, C1
Mdzinarishvili, A1
Hartmann, J1
Bickel, U2
Klein, J2
Sumbria, RK1
Higashida, T1
Peng, C1
Li, J1
Dornbos, D1
Teng, K1
Li, X1
Kinni, H1
Guthikonda, M1
Ding, Y1
Berger, C5
Dohmen, C2
Maurer, MH1
Graf, R2
Schwab, S5
Sakowitz, OW1
Kiening, KL1
Kiening, K1
Fatar, M1
Stroick, M1
Griebe, M1
Alonso, A1
Kreisel, S1
Kern, R1
Hennerici, M1
Meairs, S1
Ishikawa, M1
Sekizuka, E1
Sato, S1
Yamaguchi, N1
Inamasu, J1
Kawase, T1
Aoki, Y2
Tamura, M2
Itoh, Y2
Seto, T1
Nonaka, K1
Mukai, H1
Ukai, Y2
Schneweis, S1
Grond, M1
Staub, F1
Brinker, G1
Neveling, M1
Heiss, WD1
Frykholm, P1
Hillered, L1
Långström, B1
Persson, L1
Valtysson, J1
Watanabe, Y1
Enblad, P1
Schäbitz, WR2
Schellinger, PD1
Aschoff, A2
Steiner, T2
Georgiadis, D1

Trials

2 trials available for glycerol and Infarction, Middle Cerebral Artery

ArticleYear
Predictive value of neurochemical monitoring in large middle cerebral artery infarction.
    Stroke, 2001, Volume: 32, Issue:8

    Topics: Adult; Aged; Brain Edema; Critical Care; Electrodes, Implanted; Extracellular Space; Female; Frontal

2001
Effects of hypothermia on excitatory amino acids and metabolism in stroke patients: a microdialysis study.
    Stroke, 2002, Volume: 33, Issue:2

    Topics: Adult; Aged; Brain; Female; Glutamic Acid; Glycerol; Humans; Hypothermia, Induced; Infarction, Middl

2002

Other Studies

14 other studies available for glycerol and Infarction, Middle Cerebral Artery

ArticleYear
Study conclude that AKI appears to be a frequent complication of hyperosmolar therapy with glycerol in patients with malignant MCA infarction: we don't agree about the next study to do!
    Journal of critical care, 2022, Volume: 67

    Topics: Acute Kidney Injury; Glycerol; Humans; Infarction, Middle Cerebral Artery; Mannitol; Osmolar Concent

2022
Malignant infarction of the middle cerebral artery in a porcine model. A pilot study.
    PloS one, 2017, Volume: 12, Issue:2

    Topics: Animals; Brain; Disease Models, Animal; Female; Gene Expression; Glucose; Glycerol; Immunohistochemi

2017
Metabolic and transmitter changes in core and penumbra after middle cerebral artery occlusion in mice.
    Brain research, 2010, Feb-02, Volume: 1312

    Topics: Acetylcholine; Analysis of Variance; Animals; Choline; Corpus Striatum; Disease Models, Animal; Ener

2010
Acute depression of energy metabolism after microdialysis probe implantation is distinct from ischemia-induced changes in mouse brain.
    Neurochemical research, 2011, Volume: 36, Issue:1

    Topics: Animals; Blood-Brain Barrier; Brain; Brain Ischemia; Energy Metabolism; Glucose; Glutamates; Glycero

2011
Hypoxia-inducible factor-1α contributes to brain edema after stroke by regulating aquaporins and glycerol distribution in brain.
    Current neurovascular research, 2011, Volume: 8, Issue:1

    Topics: Animals; Aquaporin 4; Aquaporins; Brain; Brain Edema; Glycerol; Hypoxia-Inducible Factor 1, alpha Su

2011
[Cerebral microdialysis in stroke].
    Der Nervenarzt, 2004, Volume: 75, Issue:2

    Topics: Brain Edema; Critical Care; Diagnostic Imaging; Electrolytes; Energy Metabolism; Glutamic Acid; Glyc

2004
Neurochemical monitoring of glycerol therapy in patients with ischemic brain edema.
    Stroke, 2005, Volume: 36, Issue:2

    Topics: Adult; Aged; Brain; Brain Edema; Drug Monitoring; Edema; Female; Glutamic Acid; Glycerol; Humans; In

2005
Neurochemical monitoring of therapeutic effects in large human MCA infarction.
    Neurocritical care, 2008, Volume: 9, Issue:3

    Topics: Craniotomy; Critical Care; Female; Glutamic Acid; Glycerol; Humans; Hypothermia, Induced; Infarction

2008
Effect of combined ultrasound and microbubbles treatment in an experimental model of cerebral ischemia.
    Ultrasound in medicine & biology, 2008, Volume: 34, Issue:9

    Topics: Animals; Biomarkers; Brain Ischemia; Glutamic Acid; Glycerol; Infarction, Middle Cerebral Artery; La

2008
Glycerol attenuates the adherence of leukocytes in rat pial venules after transient middle cerebral artery occlusion.
    Neurological research, 1999, Volume: 21, Issue:8

    Topics: Animals; Blood Pressure; Body Temperature; Cell Adhesion; Cerebral Veins; Cryoprotective Agents; Gly

1999
Effective plasma concentration of a novel Na+/Ca2+ channel blocker NS-7 for its cerebroprotective actions in rats with a transient middle cerebral artery occlusion.
    The Journal of pharmacology and experimental therapeutics, 2001, Volume: 296, Issue:2

    Topics: Animals; Brain Chemistry; Brain Edema; Calcium Channel Blockers; Carotid Artery, Internal; Electroph

2001
Cerebroprotective action of a Na+/Ca2+ channel blocker NS-7. I. Effect on the cerebral infarction and edema at the acute stage of permanent middle cerebral artery occlusion in rats.
    Brain research, 2001, Jan-26, Volume: 890, Issue:1

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Brain; Brain Edema;

2001
Increase of interstitial glycerol reflects the degree of ischaemic brain damage: a PET and microdialysis study in a middle cerebral artery occlusion-reperfusion primate model.
    Journal of neurology, neurosurgery, and psychiatry, 2001, Volume: 71, Issue:4

    Topics: Animals; Brain Damage, Chronic; Extracellular Space; Glutamic Acid; Glycerol; Infarction, Middle Cer

2001
Neurometabolic changes during treatment with moderate hypothermia in a patient suffering from severe middle cerebral artery infarction.
    Cerebrovascular diseases (Basel, Switzerland), 2001, Volume: 12, Issue:4

    Topics: Adult; Brain Ischemia; Extracellular Space; Glutamic Acid; Glycerol; Humans; Hypothermia, Induced; I

2001