Page last updated: 2024-10-18

glycerol and Dry Eye

glycerol has been researched along with Dry Eye in 9 studies

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Research Excerpts

ExcerptRelevanceReference
"Conjunctivochalasis is a common dry eye disorder, which can cause an unstable tear film and ocular discomfort."2.80Isotonic Glycerol and Sodium Hyaluronate Containing Artificial Tear Decreases Conjunctivochalasis after One and Three Months: A Self-Controlled, Unmasked Study. ( Kiss, HJ; Németh, J, 2015)
"Nineteen control and 18 dry eye subjects used each product for 2 weeks, three times per day, in a random order, with a minimum 1-week washout between treatment periods."2.78Effectiveness of dry eye therapy under conditions of environmental stress. ( Madden, LC; Simmons, PA; Tomlinson, A, 2013)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (22.22)29.6817
2010's7 (77.78)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lievens, C1
Berdy, G1
Douglass, D1
Montaquila, S1
Lin, H1
Simmons, P1
Carlisle-Wilcox, C1
Vehige, J1
Haque, S1
Eberle Heitzmann, M1
Thumm, D1
Baudouin, C1
Kiss, HJ1
Németh, J1
Dutescu, RM1
Panfil, C1
Schrage, N1
Tung, CI1
Kottaiyan, R1
Koh, S1
Wang, Q1
Yoon, G1
Zavislan, JM1
Davio, SR1
Aquavella, JV2
Gensheimer, WG1
Kleinman, DM1
Gonzalez, MO1
Sobti, D1
Cooper, ER1
Smits, G1
Loxley, A1
Mitchnick, M1
Tomlinson, A1
Madden, LC1
Simmons, PA1
Di Pascuale, MA1
Goto, E1
Tseng, SC1
Solomon, R1
Perry, HD1
Donnenfeld, ED1
Greenman, HE1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
[NCT02280473]Phase 3188 participants (Actual)Interventional2014-11-13Completed
A Single-Center, Double-Masked, Randomized Study Evaluating the Tolerability and Efficacy of CWT-f-002 Lubricant Eye Drops Compared to Systane® Preservative-Free Eye Drops in the Treatment of the Signs and Symptoms of Dry Eye Disease (DED)[NCT05660681]34 participants (Actual)Interventional2022-12-12Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change From Baseline in Tear Break-up Time (TBUT)

TBUT is the time required for dry spots to appear on the surface of the eye after blinking. The longer it takes, the more stable the tear film. A short TBUT is a sign of poor tear film. A positive number change from baseline indicates an increase in TBUT (improvement). The eye with shorter average TBUT at baseline is reported for each patient. (NCT02280473)
Timeframe: Baseline, Day 30

,
InterventionSeconds (Mean)
BaselineChange from Baseline at Day 30 (N-94, 93)
REFRESH LIQUIGEL®5.400.70
Refresh Optive® Gel Drops5.380.84

Change From Baseline in the Combined Corneal and Conjunctival Staining Scores

The cornea is the transparent front part of the eye which covers the iris and pupil. The conjunctiva is the clear membrane covering the white surface of the eye. The cornea is divided into 5 zones and the nasal and temporal conjunctiva is divided into 6 zones. The combined staining score is based on the sum of the five zones on the cornea and the six zones on the conjunctiva. Each zone is graded on a 0-5 scale (0=None; 1=trace; 2=mild; 3=moderate; 4=severe; 5=very severe), for a total score ranging from 0-55. The higher the score, the worse the dry eye condition. A negative number change from baseline represents a decrease in the severity of staining (improvement). The eye with higher score at baseline is reported for each subject. (NCT02280473)
Timeframe: Baseline, Day 30

,
InterventionScores on a Scale (Mean)
BaselineChange from Baseline at Day 30 (N=93, 91)
REFRESH LIQUIGEL®11.8-2.0
Refresh Optive® Gel Drops10.9-1.7

Change From Baseline in the Ocular Surface Disease Index© (OSDI©) Score

The OSDI is a 12-question survey for patients to document their dry eye disease symptoms. The OSDI consists of a 5-point scale (0=none of the time and 4=all of the time), with higher scores representing greater disability. The scores are totaled over the 12 questions and converted to a score of 0-100 (0=no disability and 100=complete disability). A negative number change from baseline represents an improvement. (NCT02280473)
Timeframe: Baseline, Day 30

,
InterventionScores on a Scale (Mean)
BaselineChange from Baseline at Day 30
REFRESH LIQUIGEL®40.43-7.48
Refresh Optive® Gel Drops42.44-10.29

Change From Baseline in the OSDI© Score

The OSDI is a 12-question survey for patients to document their dry eye disease symptoms. The OSDI consists of a 5-point scale (0=none of the time and 4=all of the time), with higher scores representing greater disability. The scores are totaled over the 12 questions and converted to a score of 0-100 (0=no disability and 100=complete disability). A negative number change from baseline represents an improvement. (NCT02280473)
Timeframe: Baseline, Day 7

,
InterventionScores on a Scale (Mean)
BaselineChange from Baseline at Day 7
REFRESH LIQUIGEL®40.43-2.34
Refresh Optive® Gel Drops42.44-5.74

Change From Baseline in the Schirmer Test

The Schirmer's Test measures the rate of the secretion of tears produced by the eye over 5 minutes. The results indicate the presence of dry eye. The eye with the lower value at Baseline was used for Analysis. Normal = greater than or equal to 15 millimeters (mm) of tears, Dry Eye = less than 15 mm of tears.. The smaller the number, the more severe the dry eye. A positive number change from Baseline indicates improvement. The eye with the lower value at baseline is used for each subject. (NCT02280473)
Timeframe: Baseline, Day 30

,
Interventionmm/5 min (Mean)
BaselineChange from Baseline at Day 30 (N=88, 86)
REFRESH LIQUIGEL®11.320.69
Refresh Optive® Gel Drops9.980.89

Reviews

1 review available for glycerol and Dry Eye

ArticleYear
A review of the efficacy, safety and tolerability of Lacrycon
    Journal francais d'ophtalmologie, 2019, Volume: 42, Issue:6

    Topics: Acrylic Resins; Clinical Trials as Topic; Drug Administration Schedule; Dry Eye Syndromes; Glycerol;

2019

Trials

6 trials available for glycerol and Dry Eye

ArticleYear
Evaluation of an enhanced viscosity artificial tear for moderate to severe dry eye disease: A multicenter, double-masked, randomized 30-day study.
    Contact lens & anterior eye : the journal of the British Contact Lens Association, 2019, Volume: 42, Issue:4

    Topics: Administration, Ophthalmic; Adult; Aged; Carboxymethylcellulose Sodium; Double-Blind Method; Drug Co

2019
Isotonic Glycerol and Sodium Hyaluronate Containing Artificial Tear Decreases Conjunctivochalasis after One and Three Months: A Self-Controlled, Unmasked Study.
    PloS one, 2015, Volume: 10, Issue:7

    Topics: Adult; Aged; Aged, 80 and over; Conjunctiva; Conjunctival Diseases; Dry Eye Syndromes; Female; Glyce

2015
Noninvasive, objective, multimodal tear dynamics evaluation of 5 over-the-counter tear drops in a randomized controlled trial.
    Cornea, 2012, Volume: 31, Issue:2

    Topics: Adult; Carboxymethylcellulose Sodium; Corneal Topography; Double-Blind Method; Drug Combinations; Dr

2012
Novel formulation of glycerin 1% artificial tears extends tear film break-up time compared with Systane lubricant eye drops.
    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2012, Volume: 28, Issue:5

    Topics: Adult; Double-Blind Method; Dry Eye Syndromes; Excipients; Female; Glycerol; Humans; Lubrication; Ma

2012
Effectiveness of dry eye therapy under conditions of environmental stress.
    Current eye research, 2013, Volume: 38, Issue:2

    Topics: Carboxymethylcellulose Sodium; Cross-Over Studies; Double-Blind Method; Drug Carriers; Dry Eye Syndr

2013
Sequential changes of lipid tear film after the instillation of a single drop of a new emulsion eye drop in dry eye patients.
    Ophthalmology, 2004, Volume: 111, Issue:4

    Topics: Adult; Aged; Diagnostic Techniques, Ophthalmological; Drug Combinations; Dry Eye Syndromes; Emulsion

2004

Other Studies

2 other studies available for glycerol and Dry Eye

ArticleYear
Comparison of the effects of various lubricant eye drops on the in vitro rabbit corneal healing and toxicity.
    Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 2017, Mar-02, Volume: 69, Issue:3

    Topics: Animals; Carboxymethylcellulose Sodium; Cornea; Disease Models, Animal; Dry Eye Syndromes; Glycerol;

2017
Slitlamp biomicroscopy of the tear film of patients using topical Restasis and Refresh Endura.
    Journal of cataract and refractive surgery, 2005, Volume: 31, Issue:4

    Topics: Administration, Topical; Cyclosporine; Diagnostic Techniques, Ophthalmological; Drug Therapy, Combin

2005