glycerol has been researched along with Dry Eye in 9 studies
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| Excerpt | Relevance | Reference |
|---|---|---|
| "Conjunctivochalasis is a common dry eye disorder, which can cause an unstable tear film and ocular discomfort." | 2.80 | Isotonic Glycerol and Sodium Hyaluronate Containing Artificial Tear Decreases Conjunctivochalasis after One and Three Months: A Self-Controlled, Unmasked Study. ( Kiss, HJ; Németh, J, 2015) |
| "Nineteen control and 18 dry eye subjects used each product for 2 weeks, three times per day, in a random order, with a minimum 1-week washout between treatment periods." | 2.78 | Effectiveness of dry eye therapy under conditions of environmental stress. ( Madden, LC; Simmons, PA; Tomlinson, A, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 7 (77.78) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lievens, C | 1 |
| Berdy, G | 1 |
| Douglass, D | 1 |
| Montaquila, S | 1 |
| Lin, H | 1 |
| Simmons, P | 1 |
| Carlisle-Wilcox, C | 1 |
| Vehige, J | 1 |
| Haque, S | 1 |
| Eberle Heitzmann, M | 1 |
| Thumm, D | 1 |
| Baudouin, C | 1 |
| Kiss, HJ | 1 |
| Németh, J | 1 |
| Dutescu, RM | 1 |
| Panfil, C | 1 |
| Schrage, N | 1 |
| Tung, CI | 1 |
| Kottaiyan, R | 1 |
| Koh, S | 1 |
| Wang, Q | 1 |
| Yoon, G | 1 |
| Zavislan, JM | 1 |
| Davio, SR | 1 |
| Aquavella, JV | 2 |
| Gensheimer, WG | 1 |
| Kleinman, DM | 1 |
| Gonzalez, MO | 1 |
| Sobti, D | 1 |
| Cooper, ER | 1 |
| Smits, G | 1 |
| Loxley, A | 1 |
| Mitchnick, M | 1 |
| Tomlinson, A | 1 |
| Madden, LC | 1 |
| Simmons, PA | 1 |
| Di Pascuale, MA | 1 |
| Goto, E | 1 |
| Tseng, SC | 1 |
| Solomon, R | 1 |
| Perry, HD | 1 |
| Donnenfeld, ED | 1 |
| Greenman, HE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| [NCT02280473] | Phase 3 | 188 participants (Actual) | Interventional | 2014-11-13 | Completed | ||
| A Single-Center, Double-Masked, Randomized Study Evaluating the Tolerability and Efficacy of CWT-f-002 Lubricant Eye Drops Compared to Systane® Preservative-Free Eye Drops in the Treatment of the Signs and Symptoms of Dry Eye Disease (DED)[NCT05660681] | 34 participants (Actual) | Interventional | 2022-12-12 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
TBUT is the time required for dry spots to appear on the surface of the eye after blinking. The longer it takes, the more stable the tear film. A short TBUT is a sign of poor tear film. A positive number change from baseline indicates an increase in TBUT (improvement). The eye with shorter average TBUT at baseline is reported for each patient. (NCT02280473)
Timeframe: Baseline, Day 30
| Intervention | Seconds (Mean) | |
|---|---|---|
| Baseline | Change from Baseline at Day 30 (N-94, 93) | |
| REFRESH LIQUIGEL® | 5.40 | 0.70 |
| Refresh Optive® Gel Drops | 5.38 | 0.84 |
The cornea is the transparent front part of the eye which covers the iris and pupil. The conjunctiva is the clear membrane covering the white surface of the eye. The cornea is divided into 5 zones and the nasal and temporal conjunctiva is divided into 6 zones. The combined staining score is based on the sum of the five zones on the cornea and the six zones on the conjunctiva. Each zone is graded on a 0-5 scale (0=None; 1=trace; 2=mild; 3=moderate; 4=severe; 5=very severe), for a total score ranging from 0-55. The higher the score, the worse the dry eye condition. A negative number change from baseline represents a decrease in the severity of staining (improvement). The eye with higher score at baseline is reported for each subject. (NCT02280473)
Timeframe: Baseline, Day 30
| Intervention | Scores on a Scale (Mean) | |
|---|---|---|
| Baseline | Change from Baseline at Day 30 (N=93, 91) | |
| REFRESH LIQUIGEL® | 11.8 | -2.0 |
| Refresh Optive® Gel Drops | 10.9 | -1.7 |
The OSDI is a 12-question survey for patients to document their dry eye disease symptoms. The OSDI consists of a 5-point scale (0=none of the time and 4=all of the time), with higher scores representing greater disability. The scores are totaled over the 12 questions and converted to a score of 0-100 (0=no disability and 100=complete disability). A negative number change from baseline represents an improvement. (NCT02280473)
Timeframe: Baseline, Day 30
| Intervention | Scores on a Scale (Mean) | |
|---|---|---|
| Baseline | Change from Baseline at Day 30 | |
| REFRESH LIQUIGEL® | 40.43 | -7.48 |
| Refresh Optive® Gel Drops | 42.44 | -10.29 |
The OSDI is a 12-question survey for patients to document their dry eye disease symptoms. The OSDI consists of a 5-point scale (0=none of the time and 4=all of the time), with higher scores representing greater disability. The scores are totaled over the 12 questions and converted to a score of 0-100 (0=no disability and 100=complete disability). A negative number change from baseline represents an improvement. (NCT02280473)
Timeframe: Baseline, Day 7
| Intervention | Scores on a Scale (Mean) | |
|---|---|---|
| Baseline | Change from Baseline at Day 7 | |
| REFRESH LIQUIGEL® | 40.43 | -2.34 |
| Refresh Optive® Gel Drops | 42.44 | -5.74 |
The Schirmer's Test measures the rate of the secretion of tears produced by the eye over 5 minutes. The results indicate the presence of dry eye. The eye with the lower value at Baseline was used for Analysis. Normal = greater than or equal to 15 millimeters (mm) of tears, Dry Eye = less than 15 mm of tears.. The smaller the number, the more severe the dry eye. A positive number change from Baseline indicates improvement. The eye with the lower value at baseline is used for each subject. (NCT02280473)
Timeframe: Baseline, Day 30
| Intervention | mm/5 min (Mean) | |
|---|---|---|
| Baseline | Change from Baseline at Day 30 (N=88, 86) | |
| REFRESH LIQUIGEL® | 11.32 | 0.69 |
| Refresh Optive® Gel Drops | 9.98 | 0.89 |
1 review available for glycerol and Dry Eye
| Article | Year |
|---|---|
A review of the efficacy, safety and tolerability of Lacrycon
Topics: Acrylic Resins; Clinical Trials as Topic; Drug Administration Schedule; Dry Eye Syndromes; Glycerol; | 2019 |
6 trials available for glycerol and Dry Eye
| Article | Year |
|---|---|
Evaluation of an enhanced viscosity artificial tear for moderate to severe dry eye disease: A multicenter, double-masked, randomized 30-day study.
Topics: Administration, Ophthalmic; Adult; Aged; Carboxymethylcellulose Sodium; Double-Blind Method; Drug Co | 2019 |
Isotonic Glycerol and Sodium Hyaluronate Containing Artificial Tear Decreases Conjunctivochalasis after One and Three Months: A Self-Controlled, Unmasked Study.
Topics: Adult; Aged; Aged, 80 and over; Conjunctiva; Conjunctival Diseases; Dry Eye Syndromes; Female; Glyce | 2015 |
Noninvasive, objective, multimodal tear dynamics evaluation of 5 over-the-counter tear drops in a randomized controlled trial.
Topics: Adult; Carboxymethylcellulose Sodium; Corneal Topography; Double-Blind Method; Drug Combinations; Dr | 2012 |
Novel formulation of glycerin 1% artificial tears extends tear film break-up time compared with Systane lubricant eye drops.
Topics: Adult; Double-Blind Method; Dry Eye Syndromes; Excipients; Female; Glycerol; Humans; Lubrication; Ma | 2012 |
Effectiveness of dry eye therapy under conditions of environmental stress.
Topics: Carboxymethylcellulose Sodium; Cross-Over Studies; Double-Blind Method; Drug Carriers; Dry Eye Syndr | 2013 |
Sequential changes of lipid tear film after the instillation of a single drop of a new emulsion eye drop in dry eye patients.
Topics: Adult; Aged; Diagnostic Techniques, Ophthalmological; Drug Combinations; Dry Eye Syndromes; Emulsion | 2004 |
2 other studies available for glycerol and Dry Eye
| Article | Year |
|---|---|
Comparison of the effects of various lubricant eye drops on the in vitro rabbit corneal healing and toxicity.
Topics: Animals; Carboxymethylcellulose Sodium; Cornea; Disease Models, Animal; Dry Eye Syndromes; Glycerol; | 2017 |
Slitlamp biomicroscopy of the tear film of patients using topical Restasis and Refresh Endura.
Topics: Administration, Topical; Cyclosporine; Diagnostic Techniques, Ophthalmological; Drug Therapy, Combin | 2005 |