Page last updated: 2024-10-18

glycerol and Direct Hyperbilirubinemia, Neonatal

glycerol has been researched along with Direct Hyperbilirubinemia, Neonatal in 2 studies

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Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (50.00)29.6817
2010's1 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Fallah, R1
Fallahzadeh, MA1
Noori-Shadkam, M1
Bader, D1
Yanir, Y1
Kugelman, A1
Wilhelm-Kafil, M1
Riskin, A1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Use of Glycerin Suppositories to Reduce Hyperbilirubinemia in Premature Infants Requiring Phototherapy[NCT01746511]79 participants (Actual)Interventional2012-07-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Length of Initial Round of Phototherapy

time start to time finally off phototherapy, including any breaks during which they were off (NCT01746511)
Timeframe: from time of enrollment to time of discharge, for a maximum of 10 weeks

Interventionhours (Mean)
Glycerin Suppository118
No Glycerin Suppository81

Number of Episodes of Repeat Phototherapy

"Bilirubin levels are checked at regular intervals after phototherapy is discontinued to make sure levels are safe. Depending on rate of rise and predetermined unsafe bilirubin level, phototherapy may be restarted." (NCT01746511)
Timeframe: from time of enrollment to time of discharge, for a maximum of 10 weeks

Interventionepisodes of repeat phototherapy (Median)
Glycerin Suppository0
No Glycerin Suppository0

Peak Total Serum Bilirubin Level

Bilirubin levels were checked every 12 hours while the infant was under phototherapy. A bilirubin level was then to be checked at least twice, 8-12 hours or longer apart, following discontinuation of phototherapy. (NCT01746511)
Timeframe: from time of enrollment to time of discharge every 12 hours while under phototherapy, for a maximum of 10 weeks

Interventionmg/dL (Mean)
Glycerin Suppository11.3
No Glycerin Suppository12.0

Rate of Decline in Bilirubin Levels (mg/dL/hr)

Absolute change over time from peak to first discontinuation of phototherapy lights (NCT01746511)
Timeframe: from time of enrollment to time of discharge, for a maximum of 10 weeks

Interventionmg/dL/hr (Mean)
Glycerin Suppository0.4
No Glycerin Suppository0.4

Total Number of Hours of Required Phototherapy

(NCT01746511)
Timeframe: from time of enrollment to time of discharge, for a maximum of 10 weeks

Interventionhours (Mean)
Glycerin Suppository72
No Glycerin Suppository61

Trials

2 trials available for glycerol and Direct Hyperbilirubinemia, Neonatal

ArticleYear
Evaluation of safety and efficacy of purgative manna (billinaster drop) and glycerin suppository in icterus of healthy term newborns.
    Current drug safety, 2014, Volume: 9, Issue:1

    Topics: Bilirubin; Cathartics; Complex Mixtures; Double-Blind Method; Endpoint Determination; Female; Glycer

2014
Induction of early meconium evacuation: is it effective in reducing the level of neonatal hyperbilirubinemia?
    American journal of perinatology, 2005, Volume: 22, Issue:6

    Topics: ABO Blood-Group System; Bilirubin; Defecation; Female; Glycerol; Humans; Hyperbilirubinemia, Neonata

2005