glycerol has been researched along with Compensatory Hyperinsulinemia in 68 studies
Moon: The natural satellite of the planet Earth. It includes the lunar cycles or phases, the lunar month, lunar landscapes, geography, and soil.
Compensatory Hyperinsulinemia: A GLUCOSE-induced HYPERINSULINEMIA, a marker of insulin-resistant state. It is a mechanism to compensate for reduced sensitivity to insulin.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We present an infant with severe familial hyperinsulinism in whom glucose production rate, lipolysis, and gluconeogenesis from glycerol were measured by use of glucose and glycerol labelled with stable isotopes." | 7.70 | Effect of glucagon on glucose production, lipolysis, and gluconeogenesis in familial hyperinsulinism. ( Cederblad, F; Ewald, U; Gustafsson, J, 1998) |
| "To study the initial period of fat deposition in human obesity, we measured glycerol turnover in 12 children of 135-253% ideal body weight, who had continuously gained weight since the onset of obesity 2-9 yr previously." | 7.68 | Glycerol production and utilization during the early phase of human obesity. ( Bougnères, PF; Le Stunff, C, 1992) |
| "The human fatty liver takes up 2-arachidonoylglycerol and overproduces triacylglycerols containing saturated fatty acids, which might reflect increased de novo lipogenesis." | 5.14 | Splanchnic balance of free fatty acids, endocannabinoids, and lipids in subjects with nonalcoholic fatty liver disease. ( Arola, J; Castillo, S; Fielding, BA; Frayn, KN; Hodson, L; Hultcrantz, R; Kotronen, A; Olkkonen, VM; Orešič, M; Perttilä, J; Seppänen-Laakso, T; Suortti, T; Wahren, J; Westerbacka, J; Yki-Järvinen, H, 2010) |
| " Microdialysis measurements of interstitial glycerol and determination of fractional glycerol release were carried out during standardized combinations of relative hypoinsulinemia/moderate hyperglycemia (11 mmol/liter), hyperinsulinemia/ normoglycemia (5 mmol/liter), and hyperinsulinemia/moderate hyperglycemia, respectively." | 3.72 | Combined hyperinsulinemia and hyperglycemia, but not hyperinsulinemia alone, suppress human skeletal muscle lipolytic activity in vivo. ( Bolinder, J; Enoksson, S; Hagström-Toft, E; Qvisth, V; Sherwin, RS; Sjöberg, S, 2004) |
| "In this work, we studied the effect of a short-term (3 wk) and a long-term (15 wk) administration of a sucrose-rich diet (SRD) to Wistar rats on the morphological aspects and metabolic function of the epididymal adipose tissue that may contribute to the mechanism underlying the impaired glucose homeostasis and insulin resistance." | 3.71 | Duration of feeding on a sucrose-rich diet determines metabolic and morphological changes in rat adipocytes. ( D'Alessandro, ME; Lombardo, YB; Soria, A, 2001) |
| "We present an infant with severe familial hyperinsulinism in whom glucose production rate, lipolysis, and gluconeogenesis from glycerol were measured by use of glucose and glycerol labelled with stable isotopes." | 3.70 | Effect of glucagon on glucose production, lipolysis, and gluconeogenesis in familial hyperinsulinism. ( Cederblad, F; Ewald, U; Gustafsson, J, 1998) |
| "To examine the mechanism by which free fatty acids (FFA) induce insulin resistance in human skeletal muscle, glycogen, glucose-6-phosphate, and intracellular glucose concentrations were measured using carbon-13 and phosphorous-31 nuclear magnetic resonance spectroscopy in seven healthy subjects before and after a hyperinsulinemic-euglycemic clamp following a five-hour infusion of either lipid/heparin or glycerol/heparin." | 3.70 | Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity. ( Andersen, DK; Cline, GW; Dresner, A; Dufour, S; Griffin, ME; Hundal, RS; Laurent, D; Marcucci, M; Petersen, KF; Rothman, DL; Shulman, GI; Slezak, LA, 1999) |
| "To study the initial period of fat deposition in human obesity, we measured glycerol turnover in 12 children of 135-253% ideal body weight, who had continuously gained weight since the onset of obesity 2-9 yr previously." | 3.68 | Glycerol production and utilization during the early phase of human obesity. ( Bougnères, PF; Le Stunff, C, 1992) |
| "During hyperinsulinemia, interstitial concentrations of glucose in skeletal muscle decreased in response to ghrelin exposure [2." | 2.78 | Acute peripheral tissue effects of ghrelin on interstitial levels of glucose, glycerol, and lactate: a microdialysis study in healthy human subjects. ( Jørgensen, JO; Møller, N; Vestergaard, ET, 2013) |
| " Sustained suppression of non-esterified fatty acid (NEFA) and glycerol concentrations was observed with all GSK256073 doses throughout the 48-h dosing period." | 2.78 | GSK256073, a selective agonist of G-protein coupled receptor 109A (GPR109A) reduces serum glucose in subjects with type 2 diabetes mellitus. ( Byerly, RL; Dobbins, RL; Gao, FF; Le Monnier de Gouville, AC; Mahar, KM; Nachbaur, GJ; Napolitano, A; Shearn, SP, 2013) |
| "The pathogenesis of nonalcoholic steatohepatitis (NASH) is unknown." | 2.70 | Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities. ( Campbell-Sargent, C; Clore, JN; Contos, MJ; Luketic, VA; Mirshahi, F; Rizzo, WB; Sanyal, AJ; Shiffman, ML; Sterling, RK, 2001) |
| "However, hyperinsulinemia is observed in subjects with normoglycaemia and thus the paradigm above should be reevaluated." | 1.62 | Hyperinsulinemia and insulin resistance in the obese may develop as part of a homeostatic response to elevated free fatty acids: A mechanistic case-control and a population-based cohort study. ( Becattini, B; Brogren, H; Fryk, E; Gan, LM; Jansson, PA; Lind, L; Mossberg, K; Olausson, J; Piazza, S; Provenzani, A; Schmelz, M; Solinas, G; Strindberg, L, 2021) |
| "In conclusion, GIP in combination with hyperinsulinemia and slight hyperglycemia increased adipose tissue blood flow, glucose uptake, and FFA re-esterification, thus resulting in increased TAG deposition in abdominal subcutaneous adipose tissue." | 1.36 | Glucose-dependent insulinotropic polypeptide may enhance fatty acid re-esterification in subcutaneous abdominal adipose tissue in lean humans. ( Asmar, M; Bülow, J; Holst, JJ; Madsbad, S; Simonsen, L; Stallknecht, B, 2010) |
| "For this purpose, a condition of hyperinsulinemia/hypoglycaemia was obtained with an intraperitoneal (ip) injection of regular insulin (1." | 1.35 | Evidence that L-glutamine is better than L-alanine as gluconeogenic substrate in perfused liver of weaned fasted rats submitted to short-term insulin-induced hypoglycaemia. ( Bazotte, RB; Curi, R; Felisberto-Junior, AM; Garcia, RF; Oliveira-Yamashita, F, 2009) |
| "An artificial hyperinsulinemia, which was induced to delineate the potential interaction between elevated FFAs and hyperinsulinemia, revealed that hyperinsulinemia also increased FGF-21 levels in vivo, while rosiglitazone treatment had no effect." | 1.35 | Free fatty acids link metabolism and regulation of the insulin-sensitizing fibroblast growth factor-21. ( Andres, J; Biedasek, K; Bobbert, T; Clemenz, M; Kintscher, U; Mai, K; Meinus, S; Möhlig, M; Pfeiffer, AF; Reinecke, F; Sabath, M; Spranger, J; Spuler, S; Weicht, J; Weickert, MO, 2009) |
| "Obesity is strongly associated with hyperinsulinemia and insulin resistance, both primary risk factors for type 2 diabetes." | 1.34 | Nocturnal free fatty acids are uniquely elevated in the longitudinal development of diet-induced insulin resistance and hyperinsulinemia. ( Bergman, RN; Catalano, KJ; Chiu, JD; Hsu, IR; Kim, SP; Richey, JM, 2007) |
| "To understand the role of hyperinsulinemia in intramyocellular (imc) triglyceride (TG) accumulation and in regulating imcTG turnover." | 1.33 | Muscle type-dependent responses to insulin in intramyocellular triglyceride turnover in obese rats. ( Guo, Z; Zhou, L, 2005) |
| "These observations suggest that acute hyperinsulinemia inhibits imcTG synthesis and thus does not appear to promote imcTG accumulation via the synthetic pathway, at least in the short term." | 1.33 | Acute hyperinsulinemia inhibits intramyocellular triglyceride synthesis in high-fat-fed obese rats. ( Guo, Z; Jensen, MD; Zhou, L, 2006) |
| "N-Acetylglucosamine (NAG) was compared to glucose as an osmotic solute during peritoneal dialysis in rats." | 1.32 | N-Acetylglucosamine- an osmotic slute for peritoneal dialysis without inducing hyperinsulinemia. ( Breborowicz, A; Połubińska, A; Simon, M; Tam, P; Wu, G, 2004) |
| "In contrast, hyperinsulinemia suppressed endogenous glucose production by approximately 8% vs." | 1.32 | Intracerebroventricular neuropeptide Y infusion precludes inhibition of glucose and VLDL production by insulin. ( Buijs, RM; Havekes, LM; Karnekamp, BN; Pijl, H; Romijn, JA; van den Hoek, AM; Voshol, PJ, 2004) |
| "Hyperthyroidism is characterized by increased levels of circulating free fatty acids (FFA) and increased lipid oxidation, but it is uncertain which regional fat depots contribute." | 1.31 | Elevated regional lipolysis in hyperthyroidism. ( Djurhuus, CB; Gravholt, CH; Jørgensen, JO; Møller, N; Nørrelund, H; Riis, AL; Weeke, J, 2002) |
| "Because of the hyperinsulinemia and reduced NHGU, more glucose is utilized by peripheral tissues." | 1.31 | Hyperinsulinemia compensates for infection-induced impairment in net hepatic glucose uptake during TPN. ( Chen, SS; Donmoyer, CM; Ejiofor, J; Hande, SA; Lacy, DB; McGuinness, OP, 2000) |
| "Rosiglitazone treatment resulted in a 68% (P < 0." | 1.31 | The effects of rosiglitazone on insulin sensitivity, lipolysis, and hepatic and skeletal muscle triglyceride content in patients with type 2 diabetes. ( Befroy, D; Cline, GW; Dufour, S; Enocksson, S; Hundal, RS; Inzucchi, SE; Lebon, V; Mayerson, AB; Petersen, KF; Shulman, GI, 2002) |
| "During hyperinsulinemia and hypoglycemia, lactate increased (P = 0." | 1.30 | Absolute concentrations of glycerol and lactate in human skeletal muscle, adipose tissue, and blood. ( Arner, P; Bolinder, J; Enoksson, S; Hagström-Toft, E; Moberg, E, 1997) |
| "In summary, during physiological hyperinsulinemia 1) a blood flow increase was detected in the calf and forearm, but not in the studied muscles of these limbs; 2) the blood flow increased in the subcutaneous adipose tissue; and 3) the estimated arterial-interstitial glucose difference increased in both muscles studied and was larger in the forearm muscle than the arteriovenous glucose difference over the forearm." | 1.30 | Effect of physiological hyperinsulinemia on blood flow and interstitial glucose concentration in human skeletal muscle and adipose tissue studied by microdialysis. ( Henriksson, J; Lind, L; Lithell, H; Millgård, J; Rosdahl, H; Ungerstedt, U, 1998) |
| "Glycerol release was lowered by metformin during the 3-h experiment (P<0." | 1.30 | Metformin inhibits catecholamine-stimulated lipolysis in obese, hyperinsulinemic, hypertensive subjects in subcutaneous adipose tissue: an in situ microdialysis study. ( Adler, G; Alt, A; Ditschuneit, HH; Flechtner-Mors, M; Jenkinson, CP, 1999) |
| "During hyperinsulinemia (approximately 330 pmol/l), the circulating glycerol concentration was reduced to approximately 50% of the basal level of 53." | 1.29 | Role of phosphodiesterase III in the antilipolytic effect of insulin in vivo. ( Arner, P; Bolinder, J; Eriksson, S; Hagström-Toft, E, 1995) |
| "Six patients with type 2 diabetes underwent detailed metabolic studies before and after a minimum of 3 months' glibenclamide therapy." | 1.29 | The effects of glibenclamide on glucose homeostasis and lipoprotein metabolism in poorly controlled type 2 diabetes. ( Baynes, C; Elkeles, RS; Henderson, AD; Johnston, DG; Richmond, W, 1993) |
| "In altogether 31 patients with liver cirrhosis, fatty degeneration of the liver or a morphologically normal liver the free fatty acids, glycerin, ketone bodies and triglycerides were examined as parameters of the fat metabolism after nocturnal alimentary abstinence and under 2-hour glucose infusion." | 1.26 | [The behavior of lipid metabolism parameters in liver cirrhosis and fatty liver during glucose load]. ( Erler, K; Meisel, B; Rogos, R, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (17.65) | 18.7374 |
| 1990's | 17 (25.00) | 18.2507 |
| 2000's | 31 (45.59) | 29.6817 |
| 2010's | 7 (10.29) | 24.3611 |
| 2020's | 1 (1.47) | 2.80 |
| Authors | Studies |
|---|---|
| Fryk, E | 1 |
| Olausson, J | 1 |
| Mossberg, K | 1 |
| Strindberg, L | 1 |
| Schmelz, M | 1 |
| Brogren, H | 1 |
| Gan, LM | 1 |
| Piazza, S | 1 |
| Provenzani, A | 1 |
| Becattini, B | 1 |
| Lind, L | 2 |
| Solinas, G | 1 |
| Jansson, PA | 1 |
| Vestergaard, ET | 1 |
| Møller, N | 2 |
| Jørgensen, JO | 2 |
| Dobbins, RL | 1 |
| Shearn, SP | 1 |
| Byerly, RL | 1 |
| Gao, FF | 1 |
| Mahar, KM | 1 |
| Napolitano, A | 1 |
| Nachbaur, GJ | 1 |
| Le Monnier de Gouville, AC | 1 |
| Oliveira-Yamashita, F | 1 |
| Garcia, RF | 1 |
| Felisberto-Junior, AM | 1 |
| Curi, R | 1 |
| Bazotte, RB | 1 |
| Mai, K | 1 |
| Andres, J | 1 |
| Biedasek, K | 1 |
| Weicht, J | 1 |
| Bobbert, T | 1 |
| Sabath, M | 1 |
| Meinus, S | 1 |
| Reinecke, F | 1 |
| Möhlig, M | 1 |
| Weickert, MO | 1 |
| Clemenz, M | 1 |
| Pfeiffer, AF | 1 |
| Kintscher, U | 1 |
| Spuler, S | 1 |
| Spranger, J | 1 |
| Choi, JH | 1 |
| Gimble, JM | 1 |
| Vunjak-Novakovic, G | 1 |
| Kaplan, DL | 1 |
| Lucidi, P | 1 |
| Rossetti, P | 1 |
| Porcellati, F | 1 |
| Pampanelli, S | 1 |
| Candeloro, P | 1 |
| Andreoli, AM | 1 |
| Perriello, G | 1 |
| Bolli, GB | 1 |
| Fanelli, CG | 1 |
| Asmar, M | 1 |
| Simonsen, L | 1 |
| Madsbad, S | 2 |
| Stallknecht, B | 1 |
| Holst, JJ | 2 |
| Bülow, J | 1 |
| Westerbacka, J | 1 |
| Kotronen, A | 1 |
| Fielding, BA | 1 |
| Wahren, J | 1 |
| Hodson, L | 1 |
| Perttilä, J | 1 |
| Seppänen-Laakso, T | 1 |
| Suortti, T | 1 |
| Arola, J | 1 |
| Hultcrantz, R | 1 |
| Castillo, S | 1 |
| Olkkonen, VM | 1 |
| Frayn, KN | 1 |
| Orešič, M | 1 |
| Yki-Järvinen, H | 2 |
| Schauer, IE | 1 |
| Snell-Bergeon, JK | 1 |
| Bergman, BC | 1 |
| Maahs, DM | 1 |
| Kretowski, A | 1 |
| Eckel, RH | 1 |
| Rewers, M | 1 |
| Riis, AL | 1 |
| Gravholt, CH | 1 |
| Djurhuus, CB | 1 |
| Nørrelund, H | 1 |
| Weeke, J | 1 |
| Shah, P | 1 |
| Vella, A | 1 |
| Basu, A | 1 |
| Basu, R | 1 |
| Adkins, A | 1 |
| Schwenk, WF | 1 |
| Johnson, CM | 1 |
| Nair, KS | 1 |
| Jensen, MD | 2 |
| Rizza, RA | 1 |
| Van Pelt, RE | 1 |
| Gozansky, WS | 1 |
| Schwartz, RS | 1 |
| Kohrt, WM | 2 |
| Heptulla, RA | 1 |
| Stewart, A | 1 |
| Enocksson, S | 2 |
| Rife, F | 1 |
| Ma, TY | 1 |
| Sherwin, RS | 2 |
| Tamborlane, WV | 1 |
| Caprio, S | 1 |
| Courtney, CH | 1 |
| Atkinson, AB | 1 |
| Ennis, CN | 1 |
| Sheridan, B | 1 |
| Bell, PM | 1 |
| Stich, V | 1 |
| Pelikanova, T | 1 |
| Wohl, P | 1 |
| Sengenès, C | 1 |
| Zakaroff-Girard, A | 1 |
| Lafontan, M | 1 |
| Berlan, M | 1 |
| Rabasa-Lhoret, R | 1 |
| Bastard, JP | 1 |
| Jan, V | 1 |
| Ducluzeau, PH | 1 |
| Andreelli, F | 1 |
| Guebre, F | 1 |
| Bruzeau, J | 1 |
| Louche-Pellissier, C | 1 |
| MaItrepierre, C | 1 |
| Peyrat, J | 1 |
| Chagné, J | 1 |
| Vidal, H | 1 |
| Laville, M | 1 |
| Camacho, RC | 1 |
| Pencek, RR | 1 |
| Lacy, DB | 3 |
| James, FD | 1 |
| Wasserman, DH | 1 |
| Breborowicz, A | 1 |
| Połubińska, A | 1 |
| Simon, M | 2 |
| Tam, P | 1 |
| Wu, G | 1 |
| Guo, Z | 3 |
| Zhou, L | 3 |
| Qvisth, V | 1 |
| Hagström-Toft, E | 4 |
| Enoksson, S | 3 |
| Sjöberg, S | 1 |
| Bolinder, J | 4 |
| van den Hoek, AM | 1 |
| Voshol, PJ | 1 |
| Karnekamp, BN | 1 |
| Buijs, RM | 1 |
| Romijn, JA | 1 |
| Havekes, LM | 1 |
| Pijl, H | 1 |
| Connolly, CC | 1 |
| Papa, T | 1 |
| Smith, MS | 2 |
| Williams, PE | 2 |
| Moore, MC | 3 |
| Kim, SP | 1 |
| Catalano, KJ | 1 |
| Hsu, IR | 1 |
| Chiu, JD | 1 |
| Richey, JM | 1 |
| Bergman, RN | 1 |
| Blümer, RM | 1 |
| van Vonderen, MG | 1 |
| Sutinen, J | 1 |
| Hassink, E | 1 |
| Ackermans, M | 1 |
| van Agtmael, MA | 1 |
| Danner, SA | 1 |
| Reiss, P | 1 |
| Sauerwein, HP | 1 |
| Dicostanzo, CA | 1 |
| Farmer, B | 1 |
| Rodewald, TD | 1 |
| Neal, DW | 2 |
| Cherrington, AD | 2 |
| Soltész, G | 1 |
| Jenkins, PA | 1 |
| Aynsley-Green, A | 1 |
| Rogos, R | 1 |
| Meisel, B | 1 |
| Erler, K | 1 |
| Eriksson, S | 1 |
| Arner, P | 3 |
| Campillo, B | 1 |
| Bories, PN | 1 |
| Fouet, P | 1 |
| Boden, G | 1 |
| Chen, X | 1 |
| Desantis, RA | 1 |
| Kendrick, Z | 1 |
| Baynes, C | 1 |
| Elkeles, RS | 1 |
| Henderson, AD | 1 |
| Richmond, W | 1 |
| Johnston, DG | 1 |
| Andrikopoulos, S | 1 |
| Proietto, J | 1 |
| Moberg, E | 2 |
| Magnan, C | 1 |
| Laury, MC | 1 |
| Adnot, P | 1 |
| Doaré, L | 1 |
| Boucontet, L | 1 |
| Kergoat, M | 1 |
| Pénicaud, L | 1 |
| Ktorza, A | 1 |
| Gilbert, M | 1 |
| Cederblad, F | 1 |
| Ewald, U | 1 |
| Gustafsson, J | 1 |
| Rosdahl, H | 1 |
| Millgård, J | 1 |
| Lithell, H | 1 |
| Ungerstedt, U | 1 |
| Henriksson, J | 1 |
| Dresner, A | 1 |
| Laurent, D | 1 |
| Marcucci, M | 1 |
| Griffin, ME | 1 |
| Dufour, S | 2 |
| Cline, GW | 2 |
| Slezak, LA | 1 |
| Andersen, DK | 1 |
| Hundal, RS | 2 |
| Rothman, DL | 1 |
| Petersen, KF | 2 |
| Shulman, GI | 3 |
| Fisher, JS | 1 |
| Hickner, RC | 1 |
| Racette, SB | 1 |
| Binder, EF | 1 |
| Landt, M | 1 |
| de L Costello, AM | 1 |
| Pal, DK | 1 |
| Manandhar, DS | 1 |
| Rajbhandari, S | 1 |
| Land, JM | 1 |
| Patel, N | 1 |
| Flechtner-Mors, M | 1 |
| Ditschuneit, HH | 1 |
| Jenkinson, CP | 1 |
| Alt, A | 1 |
| Adler, G | 1 |
| Donmoyer, CM | 1 |
| Chen, SS | 1 |
| Hande, SA | 1 |
| Ejiofor, J | 1 |
| McGuinness, OP | 1 |
| Sanyal, AJ | 1 |
| Campbell-Sargent, C | 1 |
| Mirshahi, F | 1 |
| Rizzo, WB | 1 |
| Contos, MJ | 1 |
| Sterling, RK | 1 |
| Luketic, VA | 1 |
| Shiffman, ML | 1 |
| Clore, JN | 1 |
| Stumvoll, M | 1 |
| Wahl, HG | 1 |
| Löblein, K | 1 |
| Becker, R | 1 |
| Volk, A | 1 |
| Renn, W | 1 |
| Jacob, S | 1 |
| Häring, H | 1 |
| Danadian, K | 1 |
| Lewy, V | 1 |
| Janosky, JJ | 1 |
| Arslanian, S | 1 |
| Greer, F | 1 |
| Hudson, R | 1 |
| Ross, R | 1 |
| Graham, T | 1 |
| Soria, A | 1 |
| D'Alessandro, ME | 1 |
| Lombardo, YB | 1 |
| Shiota, M | 1 |
| Galassetti, P | 1 |
| Monohan, M | 1 |
| Mayerson, AB | 1 |
| Lebon, V | 1 |
| Befroy, D | 1 |
| Inzucchi, SE | 1 |
| Toth, MJ | 1 |
| Sites, CK | 1 |
| Poehlman, ET | 1 |
| Tchernof, A | 1 |
| Jensen, CB | 1 |
| Storgaard, H | 1 |
| Dela, F | 1 |
| Vaag, AA | 1 |
| Vidnes, J | 1 |
| Oyasaeter, S | 1 |
| Kreutner, W | 1 |
| Springer, SC | 1 |
| Sherwood, JE | 1 |
| Gardner, LB | 1 |
| Spannhake, EB | 1 |
| Reiser, S | 1 |
| Heilmann, W | 1 |
| Liebold, F | 1 |
| Fritsche, T | 1 |
| Lohmann, D | 1 |
| Kim, HJ | 1 |
| Kalkhoff, RK | 1 |
| Le Stunff, C | 1 |
| Bougnères, PF | 1 |
| Lundgren, F | 1 |
| Edén, E | 1 |
| Arfvidsson, B | 1 |
| Lundholm, K | 1 |
| Scott, AR | 1 |
| Macdonald, IA | 1 |
| Bowman, CA | 1 |
| Jeffcoate, WJ | 1 |
| Stevenson, RW | 1 |
| Hutson, NJ | 1 |
| Krupp, MN | 1 |
| Volkmann, RA | 1 |
| Holland, GF | 1 |
| Eggler, JF | 1 |
| Clark, DA | 1 |
| McPherson, RK | 1 |
| Hall, KL | 1 |
| Danbury, BH | 1 |
| Zuniga-Guajardo, S | 1 |
| Garfinkel, PE | 1 |
| Zinman, B | 1 |
| Eden, MA | 1 |
| Phaure, TA | 1 |
| Lefebvre, PJ | 1 |
| Sodoyez, JC | 1 |
| Luyckx, AS | 1 |
| Foà, PP | 1 |
| Scherstén, T | 1 |
| Nilsson, S | 1 |
| Jönsson, J | 1 |
| Poupon, R | 1 |
| Lenoir, P | 1 |
| Bourel, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Mechanistic Studies in Human Subcutaneous Adipose Tissue[NCT06065930] | 45 participants (Anticipated) | Observational | 2023-05-05 | Recruiting | |||
| Local Metabolic Effects of Ghrelin: A Clinical Microdialysis Study[NCT01595373] | Early Phase 1 | 10 participants (Actual) | Interventional | 2012-06-30 | Completed | ||
| A Randomized, Single Blind, Placebo-controlled, Three Period Crossover, Dose Selection Study to Evaluate the Effect of GSK256073, an HM74A Receptor Agonist, on Glucose and NEFA 24 Hour Profile in Type 2 Diabetic Patients.[NCT01147861] | Phase 1 | 39 participants (Actual) | Interventional | 2010-07-01 | Completed | ||
| The Effect of Type 1 Diabetes on Pan-Arterial Vascular Function and Insulin Sensitivity in Humans[NCT02490124] | 7 participants (Actual) | Observational | 2014-12-31 | Completed | |||
| The Impact of Fitness and Mineralocorticoid Receptor Blockade on Vascular Dysfunction in Adults With Type 1 Diabetes[NCT03174288] | 32 participants (Actual) | Interventional | 2015-08-31 | Completed | |||
| Metformin Therapy for Overweight Adolescents With Type 1 Diabetes (T1D)--Insulin Clamp Ancillary Study for Assessment of Insulin Resistance[NCT02045290] | Phase 3 | 37 participants (Actual) | Interventional | 2014-01-31 | Completed | ||
| A Randomized Trial of Metformin as Adjunct Therapy for Overweight Adolescents With Type 1 Diabetes[NCT01881828] | Phase 3 | 164 participants (Actual) | Interventional | 2013-09-30 | Completed | ||
| Influence of Treatment With Olanzapine or Ziprasidone on Transcapillary Glucose Transport in Human Skeletal Muscle[NCT00297960] | Phase 4 | 0 participants | Interventional | 2005-04-30 | Completed | ||
| New Electrophoretic Approaches in Studies of Obesity and Diabetes[NCT03189732] | 10 participants (Actual) | Interventional | 2015-10-01 | Completed | |||
| The Impact Of Choline Administration On Oxidative Stress And Clinical Outcome Of Patients With Non-Alcoholic Fatty Liver Disease NAFLD[NCT05200156] | 100 participants (Anticipated) | Interventional | 2022-02-01 | Recruiting | |||
| Does Combined Caffeine and Carbohydrate Ingestion Counter the Exercise-mediated Fall in Glycaemia in Individuals With Type 1 Diabetes on Insulin Degludec? The DE-CAF Study[NCT04671043] | 21 participants (Actual) | Interventional | 2022-02-04 | Completed | |||
| An Acute Randomized Dose-finding Equivalence Trial of Small, Catalytic Doses of Fructose and Allulose on Postprandial Carbohydrate Metabolism: The Fructose and Allulose Catalytic Effects (FACE) Study[NCT02459834] | 50 participants (Actual) | Interventional | 2015-11-30 | Completed | |||
| Modulation of Insulin Secretion and Insulin Sensitivity in Bangladeshi Type 2 Diabetic Subjects by an Insulin Sensitizer Pioglitazone and T2DM Association With PPARG Gene Polymorphism.[NCT01589445] | Phase 4 | 77 participants (Actual) | Interventional | 2008-11-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Change in percent body fat (NCT01881828)
Timeframe: 0-26 weeks
| Intervention | percentage of change (Mean) |
|---|---|
| Metformin | -0 |
| Oral Placebo | 1 |
(NCT01881828)
Timeframe: 0-26 weeks
| Intervention | percentile (Mean) |
|---|---|
| Metformin | -1 |
| Oral Placebo | 1 |
(NCT01881828)
Timeframe: 0-26 weeks
| Intervention | insulin per kg (Mean) |
|---|---|
| Metformin | -0.1 |
| Oral Placebo | -0.0 |
(NCT01881828)
Timeframe: 0-26 weeks
| Intervention | centimeters (Mean) |
|---|---|
| Metformin | -0 |
| Oral Placebo | 1 |
(NCT01881828)
Timeframe: 0-26 weeks
| Intervention | mm Hg (Mean) | |
|---|---|---|
| Change in Systolic | Change in Diastolic | |
| Metformin | 0 | 0 |
| Oral Placebo | -0 | 0 |
Hemoglobin A1c is a measure of glycemic control over approximately the past 3 months (NCT01881828)
Timeframe: 0-26 weeks
| Intervention | percentage (Mean) | |
|---|---|---|
| HbA1c | Change from Baseline to 26 Weeks | |
| Metformin | 9.0 | 0.2 |
| Oral Placebo | 8.9 | 0.2 |
Hemoglobin A1c is a measure of glycemic control over approximately the past 3 months (NCT01881828)
Timeframe: 0-26 weeks
| Intervention | percentage of participants (Number) | ||
|---|---|---|---|
| HbA1c Decrease ≥0.5% | HbA1c Increase ≥0.5% | HbA1c <7.5% | |
| Metformin | 19 | 44 | 3 |
| Oral Placebo | 18 | 35 | 4 |
(NCT01881828)
Timeframe: 0-26 weeks
| Intervention | mg/dL (Mean) | ||||
|---|---|---|---|---|---|
| Change in LDL | Change in VLDL | Change in HDL | Change in Triglycerides | Change in Total Cholesterol | |
| Metformin | -6 | -0 | -0 | 4 | -5 |
| Oral Placebo | 2 | 1 | -1 | 6 | 3 |
Response rate was defined by ≥10% decrease of FSG or/and ≥1% decrease of HbA1c from the baseline values after 3 months treatment.48 responded to pioglitazone and 32 responded to metformin. (NCT01589445)
Timeframe: 3 months for each drug
| Intervention | mmol/l (Mean) | |
|---|---|---|
| Baseline FSG | 3rd Month FSG | |
| Metformin ( 002 Group) | 6.2 | 6.5 |
| Pioglitazone (001 Group) | 6.9 | 5.4 |
Response rate was defined by ≥10% decrease of FSG or/and ≥1% decrease of HbA1c from the baseline values after 3 months treatment.48 responded to pioglitazone and 32 responded to metformin. (NCT01589445)
Timeframe: 3 months for each drug
| Intervention | μU/ml (Mean) | |
|---|---|---|
| Baseline FSI | 3rd month FSI | |
| Metformin ( 002 Group) | 13.0 | 13.9 |
| Pioglitazone (001 Group) | 16.2 | 12.3 |
Response rate was defined by ≥10% decrease of FSG or/and ≥1% decrease of HbA1c from the baseline values after 3 months treatment.48 responded to pioglitazone and 32 responded to metformin. (NCT01589445)
Timeframe: 3 months for each drug
| Intervention | percentage (Mean) | |
|---|---|---|
| Baseline HbA1c | 3rd month HbA1c | |
| Metformin ( 002 Group) | 7.8 | 7.0 |
| Pioglitazone (001 Group) | 7.3 | 6.7 |
"Response rate was defined by ≥10% decrease of FSG or/and ≥1% decrease of HbA1c from the baseline values after 3 months treatment.48 responded to pioglitazone and 32 responded to metformin.~Analysis 1: Homeostatic Model Assessment of Beta cell function(HOMA percent B) Analysis 2: Homeostatic Model Assessment of Insulin Sensitivity (Homa percent S)" (NCT01589445)
Timeframe: 3 months for each drug
| Intervention | percentage (Mean) | |||
|---|---|---|---|---|
| Baseline HOMA percent beta cells function | 3rd month HOMA percent beta cells function | Baseline HOMA percent sensitivity | 3rd month HOMA percent sensitivity | |
| Metformin ( 002 Group) | 109.3 | 116.0 | 76.2 | 67.2 |
| Pioglitazone (001 Group) | 118.9 | 132.3 | 51.1 | 69.3 |
"Response rate was defined by ≥10% decrease of FSG or/and ≥1% decrease of HbA1c from the baseline values after 3 months treatment.48 responded to pioglitazone and 32 responded to metformin.~Analysis 1: Homeostasis Model Assessment Insulin Resistance(HOMA IR) Analysis 2: Quantitative Insulin sensitivity Check Index(QUICKI)" (NCT01589445)
Timeframe: 3 months for each drug
| Intervention | Score on a scale ( SI unit) (Mean) | |||
|---|---|---|---|---|
| Baseline QUICKI | 3rd month QUICKI | Baseline HOMA IR | 3rd month HOMA IR | |
| Metformin ( 002 Group) | 0.57 | 0.54 | 3.7 | 4.3 |
| Pioglitazone (001 Group) | 0.52 | 0.59 | 5.1 | 2.9 |
"Response rate was defined by ≥10% decrease of FSG or/and ≥1% decrease of HbA1c from the baseline values after 3 months treatment.48 responded to pioglitazone and 32 responded to metformin.~Analysis 1:Total Cholesterol(TC) Analysis 2:Triglyceride(TG) Analysis 3:High Density Lipoprotein(HDL) Analysis 4:Low Density Lipoprotein(LDL)" (NCT01589445)
Timeframe: 3 months for each drug
| Intervention | mg/dl (Mean) | |||||||
|---|---|---|---|---|---|---|---|---|
| Baseline TC | 3rd month TC | Baseline TG | 3rd month TG | Baseline HDL | 3rd month HDL | Baseline LDL | 3rd month LDL | |
| Metformin (002 Group) | 193.0 | 177.0 | 166.0 | 175.0 | 34.4 | 34.7 | 125.6 | 112.0 |
| Pioglitazone (001 Group) | 182.0 | 178 | 183 | 195 | 33 | 33.2 | 112.8 | 105.5 |
9 trials available for glycerol and Compensatory Hyperinsulinemia
| Article | Year |
|---|---|
Acute peripheral tissue effects of ghrelin on interstitial levels of glucose, glycerol, and lactate: a microdialysis study in healthy human subjects.
Topics: Adipose Tissue; Administration, Oral; Blood Glucose; Extracellular Fluid; Fatty Acids, Nonesterified | 2013 |
GSK256073, a selective agonist of G-protein coupled receptor 109A (GPR109A) reduces serum glucose in subjects with type 2 diabetes mellitus.
Topics: C-Peptide; Cross-Over Studies; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Drug Adm | 2013 |
Splanchnic balance of free fatty acids, endocannabinoids, and lipids in subjects with nonalcoholic fatty liver disease.
Topics: 3-Hydroxybutyric Acid; Cannabinoid Receptor Modulators; Catheterization; Deuterium; Endocannabinoids | 2010 |
Comparison of the priming effects of pulsatile and continuous insulin delivery on insulin action in man.
Topics: 3-Hydroxybutyric Acid; Adult; Blood Glucose; C-Peptide; Circadian Rhythm; Fatty Acids; Female; Gastr | 2003 |
Activation of alpha2-adrenergic receptors blunts epinephrine-induced lipolysis in subcutaneous adipose tissue during a hyperinsulinemic euglycemic clamp in men.
Topics: Adipose Tissue; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Adult; Epinephrine; Glucose | 2003 |
Modified quantitative insulin sensitivity check index is better correlated to hyperinsulinemic glucose clamp than other fasting-based index of insulin sensitivity in different insulin-resistant states.
Topics: Adolescent; Adult; Aged; Blood Glucose; Diabetes Mellitus, Type 2; Fasting; Fatty Acids, Nonesterifi | 2003 |
Zidovudine/lamivudine contributes to insulin resistance within 3 months of starting combination antiretroviral therapy.
Topics: Adiponectin; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Body Composition; Glucos | 2008 |
Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities.
Topics: Adult; Aged; Biopsy; Cells, Cultured; Dicarboxylic Acids; Fatty Acids, Nonesterified; Fatty Liver; F | 2001 |
Caffeine ingestion decreases glucose disposal during a hyperinsulinemic-euglycemic clamp in sedentary humans.
Topics: Administration, Oral; Adult; C-Peptide; Caffeine; Calorimetry; Double-Blind Method; Fatty Acids, Non | 2001 |
59 other studies available for glycerol and Compensatory Hyperinsulinemia
| Article | Year |
|---|---|
Hyperinsulinemia and insulin resistance in the obese may develop as part of a homeostatic response to elevated free fatty acids: A mechanistic case-control and a population-based cohort study.
Topics: Adipose Tissue; Case-Control Studies; Cohort Studies; Diabetes Mellitus, Type 2; Fatty Acids, Nonest | 2021 |
Evidence that L-glutamine is better than L-alanine as gluconeogenic substrate in perfused liver of weaned fasted rats submitted to short-term insulin-induced hypoglycaemia.
Topics: Alanine; Animals; Fasting; Gluconeogenesis; Glucose; Glutamine; Glycerol; Hyperinsulinism; Hypoglyce | 2009 |
Free fatty acids link metabolism and regulation of the insulin-sensitizing fibroblast growth factor-21.
Topics: Cell Line; Diabetes Mellitus, Type 2; Fasting; Fatty Acids, Nonesterified; Female; Fibroblast Growth | 2009 |
Effects of hyperinsulinemia on lipolytic function of three-dimensional adipocyte/endothelial co-cultures.
Topics: Adipocytes; Coculture Techniques; Culture Media; Endothelium; Glycerol; Humans; Hyperinsulinism; Lip | 2010 |
Mechanisms of insulin resistance after insulin-induced hypoglycemia in humans: the role of lipolysis.
Topics: 3-Hydroxybutyric Acid; Blood Glucose; Epinephrine; Fat Emulsions, Intravenous; Fatty Acids, Nonester | 2010 |
Glucose-dependent insulinotropic polypeptide may enhance fatty acid re-esterification in subcutaneous abdominal adipose tissue in lean humans.
Topics: Adult; Blood Glucose; C-Peptide; Fatty Acids; Gastric Inhibitory Polypeptide; Glucose Clamp Techniqu | 2010 |
Insulin resistance, defective insulin-mediated fatty acid suppression, and coronary artery calcification in subjects with and without type 1 diabetes: The CACTI study.
Topics: Abdomen; Absorptiometry, Photon; Adipose Tissue; Adult; Blood Glucose; Body Composition; Calcium; Co | 2011 |
Insulin resistance, defective insulin-mediated fatty acid suppression, and coronary artery calcification in subjects with and without type 1 diabetes: The CACTI study.
Topics: Abdomen; Absorptiometry, Photon; Adipose Tissue; Adult; Blood Glucose; Body Composition; Calcium; Co | 2011 |
Insulin resistance, defective insulin-mediated fatty acid suppression, and coronary artery calcification in subjects with and without type 1 diabetes: The CACTI study.
Topics: Abdomen; Absorptiometry, Photon; Adipose Tissue; Adult; Blood Glucose; Body Composition; Calcium; Co | 2011 |
Insulin resistance, defective insulin-mediated fatty acid suppression, and coronary artery calcification in subjects with and without type 1 diabetes: The CACTI study.
Topics: Abdomen; Absorptiometry, Photon; Adipose Tissue; Adult; Blood Glucose; Body Composition; Calcium; Co | 2011 |
Elevated regional lipolysis in hyperthyroidism.
Topics: Abdomen; Adipose Tissue; Adult; Antithyroid Agents; Blood Flow Velocity; Energy Metabolism; Fatty Ac | 2002 |
Elevated free fatty acids impair glucose metabolism in women: decreased stimulation of muscle glucose uptake and suppression of splanchnic glucose production during combined hyperinsulinemia and hyperglycemia.
Topics: Adult; C-Peptide; Fatty Acids, Nonesterified; Female; Glucose; Glycerol; Human Growth Hormone; Human | 2003 |
Intravenous estrogens increase insulin clearance and action in postmenopausal women.
Topics: Body Composition; Estradiol; Estrogens, Conjugated (USP); Female; Glucose; Glucose Clamp Technique; | 2003 |
In situ evidence that peripheral insulin resistance in adolescents with poorly controlled type 1 diabetes is associated with impaired suppression of lipolysis: a microdialysis study.
Topics: Adipose Tissue; Adolescent; Diabetes Mellitus, Type 1; Fats; Female; Glucose; Glucose Clamp Techniqu | 2003 |
In situ evidence that peripheral insulin resistance in adolescents with poorly controlled type 1 diabetes is associated with impaired suppression of lipolysis: a microdialysis study.
Topics: Adipose Tissue; Adolescent; Diabetes Mellitus, Type 1; Fats; Female; Glucose; Glucose Clamp Techniqu | 2003 |
In situ evidence that peripheral insulin resistance in adolescents with poorly controlled type 1 diabetes is associated with impaired suppression of lipolysis: a microdialysis study.
Topics: Adipose Tissue; Adolescent; Diabetes Mellitus, Type 1; Fats; Female; Glucose; Glucose Clamp Techniqu | 2003 |
In situ evidence that peripheral insulin resistance in adolescents with poorly controlled type 1 diabetes is associated with impaired suppression of lipolysis: a microdialysis study.
Topics: Adipose Tissue; Adolescent; Diabetes Mellitus, Type 1; Fats; Female; Glucose; Glucose Clamp Techniqu | 2003 |
Suppression of endogenous glucose production by mild hyperinsulinemia during exercise is determined predominantly by portal venous insulin.
Topics: Animals; Arteries; Dogs; Epinephrine; Fatty Acids, Nonesterified; Glucagon; Gluconeogenesis; Glucose | 2004 |
N-Acetylglucosamine- an osmotic slute for peritoneal dialysis without inducing hyperinsulinemia.
Topics: Acetylglucosamine; Adsorption; Animals; Blood Glucose; Dialysis Solutions; Glucose; Glycerol; Hyperi | 2004 |
Evidence for increased and insulin-resistant lipolysis in skeletal muscle of high-fat-fed rats.
Topics: Animal Feed; Animals; Body Weight; Carbon Radioisotopes; Dietary Fats; Fatty Acids, Nonesterified; G | 2004 |
Combined hyperinsulinemia and hyperglycemia, but not hyperinsulinemia alone, suppress human skeletal muscle lipolytic activity in vivo.
Topics: Adipose Tissue; Adult; Glycerol; Humans; Hyperglycemia; Hyperinsulinism; Lipolysis; Lipoprotein Lipa | 2004 |
Intracerebroventricular neuropeptide Y infusion precludes inhibition of glucose and VLDL production by insulin.
Topics: Animals; Blood Glucose; Cerebral Ventricles; Fatty Acids, Nonesterified; Glucose; Glucose Clamp Tech | 2004 |
Muscle type-dependent responses to insulin in intramyocellular triglyceride turnover in obese rats.
Topics: Animals; Blood Glucose; Fatty Acids, Nonesterified; Glucose Clamp Technique; Glycerol; Hyperinsulini | 2005 |
Acute hyperinsulinemia inhibits intramyocellular triglyceride synthesis in high-fat-fed obese rats.
Topics: Acute Disease; Animals; Blood Glucose; Dietary Fats; Fatty Acids; Glucose; Glucose Clamp Technique; | 2006 |
Hepatic and muscle insulin action during late pregnancy in the dog.
Topics: 3-Hydroxybutyric Acid; Alanine; Animals; Blood Glucose; Dogs; Fatty Acids, Nonesterified; Female; Gl | 2007 |
Nocturnal free fatty acids are uniquely elevated in the longitudinal development of diet-induced insulin resistance and hyperinsulinemia.
Topics: Animals; Blood Glucose; Body Composition; C-Peptide; Circadian Rhythm; Diet; Dogs; Fasting; Fatty Ac | 2007 |
Hepatic portal venous delivery of a nitric oxide synthase inhibitor enhances net hepatic glucose uptake.
Topics: Animals; Blood Glucose; Carbon; Catheterization; Dogs; Dose-Response Relationship, Drug; Enzyme Inhi | 2008 |
Hyperinsulinaemic hypoglycaemia in infancy and childhood: a practical approach to diagnosis and medical treatment based on experience of 18 cases.
Topics: Blood Glucose; Child; Diazoxide; Female; Glucose; Glucose Tolerance Test; Glycerol; Humans; Hyperins | 1984 |
[The behavior of lipid metabolism parameters in liver cirrhosis and fatty liver during glucose load].
Topics: Fatty Acids, Nonesterified; Fatty Liver; Glucose; Glycerol; Humans; Hyperinsulinism; Infusions, Pare | 1982 |
Role of phosphodiesterase III in the antilipolytic effect of insulin in vivo.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adipose Tissue; Adult; Blood Glucose; Cyclic Nucleotide Phospho | 1995 |
Postprandial de novo lipogenesis in alcoholic liver cirrhosis: relationship with fuel homeostasis and nutritional status.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adipose Tissue; Adult; Body Composition; Body Weight; Butyrate | 1993 |
Effects of insulin on fatty acid reesterification in healthy subjects.
Topics: Adult; Calorimetry, Indirect; Epinephrine; Esterification; Fatty Acids, Nonesterified; Female; Glyce | 1993 |
The effects of glibenclamide on glucose homeostasis and lipoprotein metabolism in poorly controlled type 2 diabetes.
Topics: Aged; Blood Glucose; Diabetes Mellitus, Type 2; Female; Glucose Tolerance Test; Glyburide; Glycerol; | 1993 |
The biochemical basis of increased hepatic glucose production in a mouse model of type 2 (non-insulin-dependent) diabetes mellitus.
Topics: Alanine; Animals; Body Mass Index; Diabetes Mellitus; Diabetes Mellitus, Type 2; Dietary Fats; Disea | 1995 |
Absolute concentrations of glycerol and lactate in human skeletal muscle, adipose tissue, and blood.
Topics: Adipose Tissue; Adult; Analysis of Variance; Body Mass Index; Carbon Radioisotopes; Glycerol; Humans | 1997 |
Hormonal counterregulation failure in rats is related to previous hyperglycaemia-hyperinsulinaemia.
Topics: Animals; Blood Glucose; Body Weight; Catecholamines; Eating; Female; Glucagon; Glycerol; Hyperglycem | 1998 |
Effect of glucagon on glucose production, lipolysis, and gluconeogenesis in familial hyperinsulinism.
Topics: Drug Combinations; Glucagon; Gluconeogenesis; Glucose; Glycerol; Humans; Hyperinsulinism; Infant, Ne | 1998 |
Effect of physiological hyperinsulinemia on blood flow and interstitial glucose concentration in human skeletal muscle and adipose tissue studied by microdialysis.
Topics: Adipose Tissue; Adult; Female; Forearm; Glucose; Glycerol; Humans; Hyperinsulinism; Insulin; Lactic | 1998 |
beta-Adrenergic regulation of lipolysis and blood flow in human skeletal muscle in vivo.
Topics: Adrenergic beta-Antagonists; Adult; Female; Glycerol; Humans; Hyperinsulinism; Hypoglycemia; Lipolys | 1998 |
Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity.
Topics: Adolescent; Adult; Fatty Acids, Nonesterified; Female; Glucose; Glucose Clamp Technique; Glucose-6-P | 1999 |
Leptin response to insulin in humans is related to the lipolytic state of abdominal subcutaneous fat.
Topics: Abdomen; Adipose Tissue; Adult; Blood Circulation; Female; Glycerol; Humans; Hyperinsulinism; Insuli | 1999 |
Neonatal hypoglycaemia in Nepal 2. Availability of alternative fuels.
Topics: Age Factors; Blood Glucose; Cross-Sectional Studies; Energy Metabolism; Fatty Acids, Nonesterified; | 2000 |
Metformin inhibits catecholamine-stimulated lipolysis in obese, hyperinsulinemic, hypertensive subjects in subcutaneous adipose tissue: an in situ microdialysis study.
Topics: Adipose Tissue; Adult; Body Mass Index; Electric Impedance; Epinephrine; Female; Glycerol; Humans; H | 1999 |
Hyperinsulinemia compensates for infection-induced impairment in net hepatic glucose uptake during TPN.
Topics: Animals; Blood Glucose; Catheterization; Dogs; Dose-Response Relationship, Drug; Energy Metabolism; | 2000 |
A novel use of the hyperinsulinemic-euglycemic clamp technique to estimate insulin sensitivity of systemic lipolysis.
Topics: Adult; Blood Glucose; Deuterium; Fatty Acids, Nonesterified; Female; Glucose Clamp Technique; Glycer | 2001 |
Lipolysis in African-American children: is it a metabolic risk factor predisposing to obesity?
Topics: Absorptiometry, Photon; Adipose Tissue; Black People; Blood Glucose; Body Composition; Child; Deuter | 2001 |
Duration of feeding on a sucrose-rich diet determines metabolic and morphological changes in rat adipocytes.
Topics: Adipocytes; Adipose Tissue; Animals; Cell Count; Diet; Eating; Glucose Clamp Technique; Glycerol; Hy | 2001 |
Inclusion of low amounts of fructose with an intraduodenal glucose load markedly reduces postprandial hyperglycemia and hyperinsulinemia in the conscious dog.
Topics: Alanine; Animals; Blood Glucose; Dogs; Duodenum; Fructose; Glucagon; Gluconeogenesis; Glucose; Glyce | 2002 |
The effects of rosiglitazone on insulin sensitivity, lipolysis, and hepatic and skeletal muscle triglyceride content in patients with type 2 diabetes.
Topics: Adipocytes; Adipose Tissue; Blood Glucose; Body Composition; Calorimetry, Indirect; Diabetes Mellitu | 2002 |
Effect of menopausal status on lipolysis: comparison of plasma glycerol levels in middle-aged, premenopausal and early, postmenopausal women.
Topics: Abdomen; Adipose Tissue; Aging; Body Composition; Fasting; Female; Glycerol; Humans; Hyperinsulinism | 2002 |
Early differential defects of insulin secretion and action in 19-year-old caucasian men who had low birth weight.
Topics: 3-Hydroxybutyric Acid; Alanine; Birth Weight; Blood Glucose; C-Peptide; Denmark; Fatty Acids, Nonest | 2002 |
Reduced gluconeogenesis due to hyperinsulinism: hormonal and metabolic studies in an infant with hypoglycemia.
Topics: Alanine; Child, Preschool; Fatty Acids, Nonesterified; Glucagon; Gluconeogenesis; Glycerol; Humans; | 1978 |
Resistance of gluconeogenic and glycogenic pathways in obese-hyperglycemic mice.
Topics: Alanine; Animals; Enzyme Activation; Female; Genotype; Gluconeogenesis; Glucose Tolerance Test; Glyc | 1975 |
A strain specific increase in blood glycerol level of the carbohydrate-sensitive BHE rat.
Topics: Animals; Dietary Carbohydrates; Fasting; Gluconeogenesis; Glycerides; Glycerol; Hyperinsulinism; Hyp | 1977 |
[Behavior of the lipid and carbohydrate metabolism in patients with hypertriglyceridemia during exertion].
Topics: Blood Glucose; Carbohydrate Metabolism; Fatty Acids, Nonesterified; Glycerol; Humans; Hyperinsulinis | 1977 |
Sex steroid influence on triglyceride metabolism.
Topics: Adipose Tissue; Animals; Blood Glucose; Drug Combinations; Estradiol; Fatty Acids, Nonesterified; Fe | 1975 |
Glycerol production and utilization during the early phase of human obesity.
Topics: Blood Glucose; Body Weight; Child; Female; Glycerol; Humans; Hyperinsulinism; Insulin; Male; Obesity | 1992 |
Insulin time-dependent effects on the leg exchange of glucose and amino acids in man.
Topics: Amino Acids; Fatty Acids, Nonesterified; Glucose; Glycerol; Humans; Hyperinsulinism; Insulin; Kineti | 1991 |
Effect of phase of menstrual cycle on insulin sensitivity, peripheral blood flow and cardiovascular responses to hyperinsulinaemia in young women with type 1 diabetes.
Topics: 3-Hydroxybutyric Acid; Adult; Blood Glucose; Blood Pressure; Diabetes Mellitus, Type 1; Female; Fore | 1990 |
Actions of novel antidiabetic agent englitazone in hyperglycemic hyperinsulinemic ob/ob mice.
Topics: 3-Hydroxybutyric Acid; Animals; Benzopyrans; Blood Glucose; Cholesterol; Fatty Acids, Nonesterified; | 1990 |
Changes in insulin sensitivity and clearance in anorexia nervosa.
Topics: 3-Hydroxybutyric Acid; Adult; Anorexia Nervosa; Body Weight; Fatty Acids, Nonesterified; Female; Gly | 1986 |
Hyperinsulinism and carbohydrate-induced hyperlipoproteinemia.
Topics: Cholesterol; Diet Therapy; Dietary Carbohydrates; Electrophoresis; Fatty Acids, Nonesterified; Glyce | 1968 |
Adipose tissue lipolysis in golden hamsters with chronic hypoglycemia and hyperinsulinemia due to a transplantable islet cell tumor.
Topics: Adenoma, Islet Cell; Adipose Tissue; Animal Nutritional Physiological Phenomena; Animals; Antigens; | 1970 |
Hepatic lipogenesis in two cases with insulin-producing tumor of the pancreas.
Topics: Adenoma, Islet Cell; Biopsy; Blood Glucose; Carbon Isotopes; Fatty Acids; Fructose; Glycerol; Humans | 1971 |
[Changes in plasma nonesterified fatty acids and glycerol during an induced hyperglycemia test by intravenous route in alcoholic and hemochromatotic cirrhosis].
Topics: Adult; Alcoholism; Fatty Acids, Nonesterified; Female; Glucose Tolerance Test; Glycerol; Growth Horm | 1972 |