Page last updated: 2024-10-18

glycerol and Chondromalacia

glycerol has been researched along with Chondromalacia in 6 studies

Moon: The natural satellite of the planet Earth. It includes the lunar cycles or phases, the lunar month, lunar landscapes, geography, and soil.

Chondromalacia: Softening and degeneration of the CARTILAGE.

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (66.67)29.6817
2010's2 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Jing, B1
Wang, Z1
Li, B1
Cheng, Z1
Kang, Y1
Li, Q1
Hoemann, CD5
Chen, G1
Marchand, C1
Tran-Khanh, N1
Thibault, M1
Chevrier, A5
Sun, J5
Shive, MS2
Fernandes, MJ1
Poubelle, PE1
Centola, M1
El-Gabalawy, H1
Buschmann, MD4
Hurtig, M2
Rossomacha, E2
McKee, MD1
Rivard, GE1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Randomized, Comparative Multicenter Clinical Trial Evaluating BST-CarGel™ and Microfracture in Repair of Focal Articular Cartilage Lesions on the Femoral Condyle[NCT00314236]80 participants (Actual)Interventional2005-12-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Degree of Filling of the Lesion by Repair Tissue at 12 Months Through MRI.

Evaluate the efficacy of BST-CarGel® applied to a microfractured lesion as compared to microfracture alone on the degree of lesion filling of the study knee in subjects with symptomatic pain associated with cartilage damage using MRI scans. The MR images will be acquired using high resolution 3D cartilage imaging sequences, so-called cartilage morphology sequences. (NCT00314236)
Timeframe: 12 months

InterventionPercentage of lesion fill (Least Squares Mean)
Experimental92.81
Control85.22

Frequency of Adverse Events Between Study Groups

(NCT00314236)
Timeframe: 12 months

InterventionPercentage of participants (Number)
Experimental97.6
Control92.3

Repair Cartilage T2 Relaxation Time

Evaluate the efficacy of BST-CarGel® applied to a microfractured lesion as compared to microfracture alone on the repair tissue quality of the study knee in subjects with symptomatic pain associated with cartilage damage using MRI T2 mapping. T2 maps are created by calculating the T2 relaxation times for repair tissue and cartilage plates for every voxel (picture element of a MRI scan containing the average signal information of a specific spatial location of the imaged body). (NCT00314236)
Timeframe: 12 months

Interventionmilliseconds (Least Squares Mean)
Experimental70.46
Control85.04

Change From Baseline for Knee-related Pain, Stiffness and Function at 12 Months (WOMAC Parts A, B, C)

The three sub-scales: 1) Pain, 2.) stiffness and 3.) function scores ranged from 0-10. Pain had 5 items and stiffness had 2 items, and function had 17 items. The total score for pain ranged from 0 no pain to 50 worst pain. The total score for stiffness ranged from 0 no stiffness to 20 worst stiffness. The total score for function raged from 0 no function to 170 worst function. (NCT00314236)
Timeframe: 12 months

,
InterventionUnits on a scale (Least Squares Mean)
PainStiffnessFunction
Control-16.91-6.56-60.59
Experimental-16.16-5.97-55.96

Other Studies

6 other studies available for glycerol and Chondromalacia

ArticleYear
[A preliminary study of high viscous chitosan/glycerol phosphate with demineralized bone matrix to repair cartilage defects in rabbits].
    Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery, 2008, Volume: 22, Issue:12

    Topics: Animals; Biocompatible Materials; Bone Demineralization Technique; Bone Matrix; Cartilage; Cartilage

2008
Scaffold-guided subchondral bone repair: implication of neutrophils and alternatively activated arginase-1+ macrophages.
    The American journal of sports medicine, 2010, Volume: 38, Issue:9

    Topics: Adult; Angiogenesis Inducing Agents; Animals; Arginase; Arthroplasty, Subchondral; Blood Coagulation

2010
Temporal and spatial modulation of chondrogenic foci in subchondral microdrill holes by chitosan-glycerol phosphate/blood implants.
    Osteoarthritis and cartilage, 2011, Volume: 19, Issue:1

    Topics: Animals; Biomarkers; Cartilage Diseases; Cell Proliferation; Chitosan; Chondrogenesis; Coagulants; C

2011
Chitosan-glycerol phosphate/blood implants improve hyaline cartilage repair in ovine microfracture defects.
    The Journal of bone and joint surgery. American volume, 2005, Volume: 87, Issue:12

    Topics: Animals; Blood Coagulation; Cartilage Diseases; Chitosan; Coagulants; Glycerol; Hyalin; Models, Anim

2005
Chitosan-glycerol phosphate/blood implants elicit hyaline cartilage repair integrated with porous subchondral bone in microdrilled rabbit defects.
    Osteoarthritis and cartilage, 2007, Volume: 15, Issue:1

    Topics: Animals; Blood Coagulation; Cartilage Diseases; Chitosan; Coagulants; Collagen Type II; Glycerol; Hy

2007
Chitosan-glycerol phosphate/blood implants increase cell recruitment, transient vascularization and subchondral bone remodeling in drilled cartilage defects.
    Osteoarthritis and cartilage, 2007, Volume: 15, Issue:3

    Topics: Animals; Blood Coagulation; Cartilage Diseases; Chitosan; Chondrogenesis; Coagulants; Glycerol; Hyal

2007