glyburide has been researched along with Pregnancy in 252 studies
Glyburide: An antidiabetic sulfonylurea derivative with actions like those of chlorpropamide
glyburide : An N-sulfonylurea that is acetohexamide in which the acetyl group is replaced by a 2-(5-chloro-2-methoxybenzamido)ethyl group.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The relationships between glyburide concentration and the time since the last intake of glyburide and between fetal glyburide concentration and neonatal hypoglycemia were modeled with linear or logistic regressions using fractional polynomials." | 9.34 | Transplacental transfer of glyburide in women with gestational diabetes and neonatal hypoglycemia risk. ( Alvarez, JC; Bouchghoul, H; Bouyer, J; Senat, MV; Verstuyft, C, 2020) |
| "Metformin has been reported to reduce the risk of pre-eclampsia." | 8.98 | Metformin for prevention of hypertensive disorders of pregnancy in women with gestational diabetes or obesity: systematic review and meta-analysis of randomized trials. ( Abdi, A; Kalafat, E; Khalil, A; Sukur, YE; Thilaganathan, B, 2018) |
| " As with other oral hypoglycemics, the use of glyburide in pregnancy has been limited by fears of neonatal hypoglycemia following fetal exposure." | 8.84 | Safety of glyburide for gestational diabetes: a meta-analysis of pregnancy outcomes. ( Koren, G; Moretti, ME; Rezvani, M, 2008) |
| "Use of glyburide in gestational diabetes (GDM) has raised concerns about fetal and neonatal side effects, including increased birth weight." | 7.85 | Glyburide treatment in gestational diabetes is associated with increased placental glucose transporter 1 expression and higher birth weight. ( Barbour, LA; Díaz, P; Dimasuay, KG; Jang, B; Jansson, T; Koele-Schmidt, L; Powell, TL, 2017) |
| "Glyburide is thought to be safe for use during pregnancy for treatment of gestational diabetes mellitus (GDM)." | 7.81 | Association of Adverse Pregnancy Outcomes With Glyburide vs Insulin in Women With Gestational Diabetes. ( Benjamin, DK; Boggess, K; Brookhart, MA; Camelo Castillo, W; Jonsson Funk, M; Stürmer, T, 2015) |
| "Despite widespread use of glyburide to treat pregnancy-related hyperglycemia, the dosing regimen is based in large part on pharmacokinetic and pharmacodynamic studies in men and nonpregnant women." | 7.79 | A pharmacologic approach to the use of glyburide in pregnancy. ( Caritis, SN; Hebert, MF, 2013) |
| "To examine the effect of obesity on maternal and neonatal outcomes in women diagnosed with gestational diabetes mellitus (GDM) and managed with diet only, glyburide, or insulin." | 7.78 | The effect of maternal obesity on pregnancy outcomes of women with gestational diabetes controlled with diet only, glyburide, or insulin. ( Desch, C; Istwan, N; Joy, S; Rhea, D; Roman, A; Saltzman, D; Stanziano, G, 2012) |
| "We sought to investigate the association between glyburide dose, degree of severity in gestational diabetes mellitus (GDM), level of glycemic control, and pregnancy outcome in insulin- and glyburide-treated patients." | 7.73 | Insulin and glyburide therapy: dosage, severity level of gestational diabetes, and pregnancy outcome. ( Langer, O; Rosenn, B; Xenakis, EM; Yogev, Y, 2005) |
| "The purpose of this study was to identify characteristics that may predict failure of glyburide therapy for the management of A2 gestational diabetes, and to evaluate whether those that fail are at increased risk for adverse pregnancy outcomes." | 7.73 | Glyburide for the management of gestational diabetes: risk factors predictive of failure and associated pregnancy outcomes. ( Gaddipati, S; Rand, L; Rochon, M; Roth, L, 2006) |
| "Glyburide is an effective treatment for reaching glycaemic goals during pregnancy in women with GDM." | 5.41 | Glyburide therapy for gestational diabetes: Glycaemic control, maternal hypoglycaemia, and treatment failure. ( Affres, H; Bouchghoul, H; Bouyer, J; Coustols-Valat, M; Deruelle, P; Letourneau, A; Senat, MV, 2021) |
| "Hypoglycemia was defined as a blood glucose of less than 50 mg/dL, further classified as "severe hypoglycemia" if the event required the assistance of another person for resuscitation, "symptomatic hypoglycemia" if it was associated with typical neurogenic symptoms, or "asymptomatic hypoglycemia" if the biochemical reading was less than 50 mg/dL with no symptoms or accompanied by mild symptoms that did not impair the patient's ability to function." | 5.37 | Hypoglycemia in glyburide-treated gestational diabetes: is it dose-dependent? ( Brustman, L; El Daouk, M; Fuchs, A; Langer, O; Rosenn, B; Scarpelli, S, 2011) |
| " The relationships between glyburide concentration and the time since the last intake of glyburide and between fetal glyburide concentration and neonatal hypoglycemia were modeled with linear or logistic regressions using fractional polynomials." | 5.34 | Transplacental transfer of glyburide in women with gestational diabetes and neonatal hypoglycemia risk. ( Alvarez, JC; Bouchghoul, H; Bouyer, J; Senat, MV; Verstuyft, C, 2020) |
| "An evaluation of 82 patients with gestational diabetes was performed; 30 were insulin-treated, 27 were managed by diet only, and 25 were patients treated with glyburide." | 5.32 | Undiagnosed asymptomatic hypoglycemia: diet, insulin, and glyburide for gestational diabetic pregnancy. ( Ben-Haroush, A; Chen, R; Hod, M; Langer, O; Rosenn, B; Yogev, Y, 2004) |
| "To evaluate whether the addition of glyburide to diet therapy modifies pregnancy outcomes in women with mild gestational diabetes." | 5.20 | Glyburide in Women With Mild Gestational Diabetes: A Randomized Controlled Trial. ( Abbassi-Ghanavati, M; Casey, BM; Duryea, EL; Leveno, KJ; McIntire, DD; Shivvers, SA; Tudela, CM, 2015) |
| "The only significant difference in outcome between the 2 treatment drugs was that maternal weight gain during pregnancy was less in the metformin (n=40) than in the glyburide group (n=32) (10." | 5.14 | Metformin compared with glyburide for the management of gestational diabetes. ( Bertini, AM; Bizato, J; de Souza, BV; Pacheco, C; Ribeiro, TE; Silva, JC, 2010) |
| "This review study of available literature shows that metformin can be a superior option in most neonatal and maternal adverse pregnancy outcomes in women with gestational diabetes mellitus; the results need to be further updated by including future more qualified studies." | 5.12 | Effectiveness of antidiabetic agents for treatment of gestational diabetes: A methodological quality assessment of meta-analyses and network meta-analysis. ( Amiri, M; Behboudi-Gandevani, S; Bidhendi Yarandi, R; Ramezani Tehrani, F, 2021) |
| "Metformin has been reported to reduce the risk of pre-eclampsia." | 4.98 | Metformin for prevention of hypertensive disorders of pregnancy in women with gestational diabetes or obesity: systematic review and meta-analysis of randomized trials. ( Abdi, A; Kalafat, E; Khalil, A; Sukur, YE; Thilaganathan, B, 2018) |
| "The use of metformin and glyburide in pregnancy for treatment of GDM has dramatically increased since the early 2000s." | 4.98 | Oral Agents for the Treatment of Gestational Diabetes. ( Finneran, MM; Landon, MB, 2018) |
| " Glyburide significantly increased the risk of any neonatal hypoglycemia [risk ratio (RR), 1." | 4.95 | Comparison of glyburide and insulin in the management of gestational diabetes: A meta-analysis. ( Chen, L; Chen, Y; Feng, W; Irwin, DM; Liu, Y; Si, X; Song, R, 2017) |
| "Our study concluded that metformin is fastest in glucose control, with a more favorable pregnancy outcomes-would be a better option, but its rate of glucose control is the lowest." | 4.95 | Comparative efficacy and safety of oral antidiabetic drugs and insulin in treating gestational diabetes mellitus: An updated PRISMA-compliant network meta-analysis. ( Liang, HL; Ma, SJ; Tan, HZ; Xiao, YN, 2017) |
| "Our study suggested that in women with GDM, glyburide is as effective as insulin, but the risks of neonatal hypoglycemia, high fetal birth weight, and macrosomia were higher." | 4.90 | The use of glyburide in the management of gestational diabetes mellitus: a meta-analysis. ( Chen, Y; Jiang, L; Li, BY; Li, MJ; Mo, XL; Wang, SM; Zeng, YC, 2014) |
| " Research suggests that glyburide and metformin can each effectively manage hyperglycemia in pregnancy." | 4.89 | Oral agents for the management of gestational diabetes. ( Berggren, EK; Boggess, KA, 2013) |
| "Available evidence supports the use of glyburide during pregnancy." | 4.84 | Pharmacological management of gestational diabetes: an overview. ( Coustan, DR, 2007) |
| " As with other oral hypoglycemics, the use of glyburide in pregnancy has been limited by fears of neonatal hypoglycemia following fetal exposure." | 4.84 | Safety of glyburide for gestational diabetes: a meta-analysis of pregnancy outcomes. ( Koren, G; Moretti, ME; Rezvani, M, 2008) |
| " Average infant birth weight may be lower in mothers treated with insulin than with glyburide." | 4.84 | Therapeutic management, delivery, and postpartum risk assessment and screening in gestational diabetes. ( Baptiste-Roberts, K; Barone, BB; Bass, EB; Bennett, WL; Bolen, S; Gary, TL; Golden, SH; Neale, DM; Nicholson, WK; Wilson, LM; Witkop, CT, 2008) |
| "4%) had at least one episode of hypoglycemia, most often in the setting of glyburide." | 4.12 | Antenatal maternal hypoglycemia in women with gestational diabetes mellitus and neonatal outcomes. ( Cruz, M; Davitt, C; Harrison, RK; Palatnik, A; Saravanan, V, 2022) |
| "Time-varying exposure to glyburide vs insulin during pregnancy." | 4.12 | Association of Glyburide and Subcutaneous Insulin With Perinatal Complications Among Women With Gestational Diabetes. ( Badon, SE; Ferrara, A; Hedderson, MM; Neugebauer, R; Pimentel, N; Regenstein, A; Xu, F, 2022) |
| "Metformin is beneficial for GDM women to control total GWG compared with insulin, regulate fetal birth weight more than insulin and glyburide, and increase the risk of unmet treatment targets compared with insulin." | 4.12 | Efficacy and safety of hypoglycemic agents on gestational diabetes mellitus in women: A Bayesian network analysis of randomized controlled trials. ( Chen, H; Cui, W; Guo, H; Huang, L; Jing, Y; Liu, X; Song, L; Sun, B; Wang, M; Wang, N; Wang, T; Xu, J, 2022) |
| "Use of glyburide in gestational diabetes (GDM) has raised concerns about fetal and neonatal side effects, including increased birth weight." | 3.85 | Glyburide treatment in gestational diabetes is associated with increased placental glucose transporter 1 expression and higher birth weight. ( Barbour, LA; Díaz, P; Dimasuay, KG; Jang, B; Jansson, T; Koele-Schmidt, L; Powell, TL, 2017) |
| "To evaluate treatment effectiveness (diet alone, insulin or glyburide) on maternal weight gain in gestational diabetes (GDM)." | 3.83 | Weight gain in gestational diabetes: the effect of treatment modality. ( Bimson, B; Brustman, LE; El Daouk, M; Langer, O; Scarpelli, S, 2016) |
| "The 5 mg/day glyburide dose did not increase maternal hypoglycemia (26% in the 2." | 3.83 | Examining the Starting Dose of Glyburide in Gestational Diabetes. ( Biggio, JR; Glover, AV; Harper, LM; Tita, A, 2016) |
| "To evaluate the safety, efficacy and pregnancy outcomes of insulin detemir (IDet) versus glyburide treatment in women with gestational diabetes mellitus (GDM)." | 3.83 | Insulin detemir versus glyburide in women with gestational diabetes mellitus. ( Ashwal, E; Hod, M; Koren, R; Toledano, Y, 2016) |
| "Glyburide is thought to be safe for use during pregnancy for treatment of gestational diabetes mellitus (GDM)." | 3.81 | Association of Adverse Pregnancy Outcomes With Glyburide vs Insulin in Women With Gestational Diabetes. ( Benjamin, DK; Boggess, K; Brookhart, MA; Camelo Castillo, W; Jonsson Funk, M; Stürmer, T, 2015) |
| "Our PBPK model integrating prior physiological knowledge, in vitro and in vivo data, allowed successful prediction of methadone and glyburide disposition during pregnancy." | 3.80 | Expansion of a PBPK model to predict disposition in pregnant women of drugs cleared via multiple CYP enzymes, including CYP2B6, CYP2C9 and CYP2C19. ( Ke, AB; Nallani, SC; Rostami-Hodjegan, A; Unadkat, JD; Zhao, P, 2014) |
| "Despite widespread use of glyburide to treat pregnancy-related hyperglycemia, the dosing regimen is based in large part on pharmacokinetic and pharmacodynamic studies in men and nonpregnant women." | 3.79 | A pharmacologic approach to the use of glyburide in pregnancy. ( Caritis, SN; Hebert, MF, 2013) |
| "Neonatal chemical hypoglycemia occurs more frequently in infants from women with type 2 diabetes and GDM treated with glyburide or insulin." | 3.78 | Neonatal chemical hypoglycemia in newborns from pregnancies complicated by type 2 and gestational diabetes mellitus - the importance of neonatal ponderal index. ( Aguayo, J; Hanley, AA; Kim, JH; Moore, TR; Ramos, GA; Warshak, CR, 2012) |
| "To examine the effect of obesity on maternal and neonatal outcomes in women diagnosed with gestational diabetes mellitus (GDM) and managed with diet only, glyburide, or insulin." | 3.78 | The effect of maternal obesity on pregnancy outcomes of women with gestational diabetes controlled with diet only, glyburide, or insulin. ( Desch, C; Istwan, N; Joy, S; Rhea, D; Roman, A; Saltzman, D; Stanziano, G, 2012) |
| "This article discusses a retrospective study of 8,711 women, delivering at ≥ 20 weeks' gestation, who had a prenatal 2-h 75-g OGTT without a prior 50-g challenge and were not treated with insulin, glyburide, diet, and/or exercise during pregnancy." | 3.76 | Clinical outcomes of pregnancies complicated by mild gestational diabetes mellitus differ by combinations of abnormal oral glucose tolerance test values. ( Black, MH; Lawrence, JM; Sacks, DA; Xiang, AH, 2010) |
| "We sought to investigate the association between glyburide dose, degree of severity in gestational diabetes mellitus (GDM), level of glycemic control, and pregnancy outcome in insulin- and glyburide-treated patients." | 3.73 | Insulin and glyburide therapy: dosage, severity level of gestational diabetes, and pregnancy outcome. ( Langer, O; Rosenn, B; Xenakis, EM; Yogev, Y, 2005) |
| "In a large managed care organization, glyburide was at least as effective as insulin in achieving glycemic control and similar birth weights in women with GDM who failed diet therapy." | 3.73 | Comparison of glyburide and insulin for the management of gestational diabetes in a large managed care organization. ( Ching, JY; Ferrara, A; Field, DR; Jacobson, GF; Kirby, RS; Ramos, GA, 2005) |
| "This is the first direct evidence of active glyburide transport from the fetus to the mother and, in general, of any medicinal drug used during pregnancy." | 3.73 | Perfusion studies of glyburide transfer across the human placenta: implications for fetal safety. ( Klein, J; Koren, G; Kraemer, J; Lubetsky, A, 2006) |
| "Glyburide was more likely to fail in women diagnosed earlier in pregnancy, of older age and multiparity, and with higher fasting glucoses, suggesting that earlier glucose intolerance and a reduced capacity to respond to an insulin secretagogue may distinguish this group." | 3.73 | Predictors of glyburide failure in the treatment of gestational diabetes. ( Barbour, LA; Davies, JK; Kahn, BF; Lynch, AM; Reynolds, RM, 2006) |
| "The purpose of this study was to identify characteristics that may predict failure of glyburide therapy for the management of A2 gestational diabetes, and to evaluate whether those that fail are at increased risk for adverse pregnancy outcomes." | 3.73 | Glyburide for the management of gestational diabetes: risk factors predictive of failure and associated pregnancy outcomes. ( Gaddipati, S; Rand, L; Rochon, M; Roth, L, 2006) |
| "Persons with gestational and pregestational diabetes during pregnancy may require pharmacologic agents to achieve pregnancy glycemic targets, and the available medications for use in pregnancy are limited." | 3.01 | Medications for Managing Preexisting and Gestational Diabetes in Pregnancy. ( Caughey, AB; Rickert, M; Valent, AM, 2023) |
| " Data are limited regarding the pharmacodynamic effects of metformin and glyburide during pregnancy." | 2.94 | Pharmacodynamics of Glyburide, Metformin, and Glyburide/Metformin Combination Therapy in the Treatment of Gestational Diabetes Mellitus. ( Ahmed, MS; Brown, LM; Brown, Z; Caritis, S; Clark, S; Easterling, TR; Flood Nichols, SK; Haas, DM; Haneline, LS; Hebert, MF; Ma, X; Manuck, TA; Quinney, SK; Ren, Z; Shen, DD; Shireman, LM; Shuster, DL; Thummel, KE; Tita, AT; Venkataramanan, R, 2020) |
| "In women with gestational diabetes mellitus (GDM) requiring pharmacotherapy, insulin was the established first-line treatment." | 2.90 | SUGAR-DIP trial: oral medication strategy versus insulin for diabetes in pregnancy, study protocol for a multicentre, open-label, non-inferiority, randomised controlled trial. ( Akerboom, BMC; Assouiki, F; Bosmans, JE; Braams-Lisman, BAM; Brouwer, CB; Daemen-Gubbels, CRGM; de Boer, K; de Galan, BE; de Koning, EJP; de Valk, HW; de Wit, L; deVries, JH; Diekman, MJM; Dullemond, RC; Eskes, SA; Evers, IM; Franx, A; Galjaard, S; Gallas, PRJ; Groenendaal, F; Heijligenberg, R; Hermes, W; Hermsen, BB; Horree, N; Huisjes, AJM; IJzerman, RG; Jansen, HJ; Kiewiet-Kemper, RM; Klooker, TK; Kuppens, SMI; Laan, R; Mensing van Charante, NA; Mol, BW; Naaktgeboren, CA; Oosterwerff, MM; Painter, RC; Potter van Loon, BJ; Rademaker, D; Sanson-van Praag, ME; Schippers, DH; Soeters, MR; Sueters, M; van Bemmel, T; van Bon, AC; van den Akker, ES; van den Beld, AW; van der Heijden, OWH; van der Made, FW; van Houtum, WH; van Laar, JOEH; van Leeuwen, M; van Meir, CA; van Rijn, BB; Veldhuis-Vlug, AG; Vermeulen, MAR; Verwij-Didden, MAL; Vidarsdottir, S; Visser, W; Vogelvang, TE; Voormolen, DN; Wijbenga, JAM; Wouters, MGAJ; Wouters-van Poppel, P; Zandstra, M; Zwart, JJ; Zwertbroek, R, 2019) |
| " The starting dosage for glyburide was 2." | 2.87 | Effect of Glyburide vs Subcutaneous Insulin on Perinatal Complications Among Women With Gestational Diabetes: A Randomized Clinical Trial. ( Affres, H; Beucher, G; Bourcigaux, N; Bouyer, J; Bretelle, F; Castera, V; Cazaubiel, M; Coustols-Valat, M; De Carne, C; Deruelle, P; Desbriere, R; Héron, I; Jacquier, JF; Laboureau, S; Legardeur, H; Letourneau, A; Maillot, F; Mitanchez, D; Morin, M; Rod, A; Rolland, C; Sénat, MV; Sentilhes, L; Simon, E; Verspyck, E, 2018) |
| "Metformin is widely used to treat gestational diabetes (GDM), but many women remain hyperglycaemic and require additional therapy." | 2.84 | Glibenclamide and metfoRmin versus stAndard care in gEstational diabeteS (GRACES): a feasibility open label randomised trial. ( Alexander, CI; Bell, JL; Denison, FC; Juszczak, E; Lindsay, RS; Love, CDB; Mackenzie, F; Norman, JE; Penneycard, J; Reynolds, RM; Stenson, B; Strachan, MWJ; Whyte, S, 2017) |
| "Glyburide was started in 53 patients and metformin in 51." | 2.84 | Glyburide Versus Metformin and Their Combination for the Treatment of Gestational Diabetes Mellitus: A Randomized Controlled Study. ( Gam Ze Letova, Y; Hasanein, J; Hissin, N; Nachum, Z; Salim, R; Suleiman, A; Yefet, E; Zafran, N, 2017) |
| "Oral hypoglycemic drugs for the treatment of gestational diabetes mellitus (GDM) are still controversial because they can pass through the placenta." | 2.82 | Comparison of the effectiveness and safety of insulin and oral hypoglycemic drugs in the treatment of gestational diabetes mellitus: a meta-analysis of 26 randomized controlled trials. ( Gao, C; Jia, X; Li, C; Shi, H; Zhang, L; Zhang, X, 2022) |
| "In a south Indian population with gestational diabetes, metformin was associated with better neonatal outcomes than glibenclamide." | 2.80 | Comparison of neonatal outcomes in women with gestational diabetes with moderate hyperglycaemia on metformin or glibenclamide--a randomised controlled trial. ( Abraham, A; Antonisamy, B; Beck, M; Benjamin, SJ; George, A; Jana, AK; Mathews, JE; Sam, D; Thomas, N, 2015) |
| "Women with gestational diabetes mellitus were randomly allocated to two insulin and glyburide groups and compared with maternal and neonatal outcome." | 2.80 | Comparison of glyburide and insulin in women with gestational diabetes mellitus and associated perinatal outcome: a randomized clinical trial. ( Faalpoor, Z; Heidar, Z; Jamali, R; Mirzamoradi, M; Naeiji, Z, 2015) |
| "Glyburide was found to be as efficacious as insulin in achieving euglycemia in the treatment of gestational diabetic women who require treatment beyond diet control." | 2.78 | Glyburide as treatment option for gestational diabetes mellitus. ( Mayanglambam, RD; Tempe, A, 2013) |
| "Patients with gestational diabetes who did not achieve glycemic control on diet were randomly assigned to metformin (n=75) or glyburide (n=74) as single agents." | 2.75 | Metformin compared with glyburide in gestational diabetes: a randomized controlled trial. ( Clokey, D; Curet, LB; Moore, LE; Rappaport, VJ, 2010) |
| " Women with GDM in whom glyburide treatment has failed may benefit from alternative medication or dosage escalation; however, fetal safety should be kept in mind." | 2.74 | Are we optimizing gestational diabetes treatment with glyburide? The pharmacologic basis for better clinical practice. ( Ahmed, MS; Blough, D; Caritis, SN; Carr, DB; Cobelli, C; Easterling, TR; Hankins, GD; Hebert, MF; Kelly, EJ; Krudys, KM; Ma, X; Mattison, DR; Miodovnik, M; Naraharisetti, SB; Snodgrass, WR; Umans, JG; Unadkat, JD; Vicini, P, 2009) |
| "To study glibenclamide as a treatment for gestational diabetes mellitus (GDM) and its impact on newborn birth weight and neonatal glycemia as compared to insulin." | 2.73 | [Glibenclamide in the treatment for gestational diabetes mellitus in a compared study to insulin]. ( Aquim, GM; Bebber, FR; Becker, F; Bertini, AM; Silva, JC; Taborda, W; Viesi, JM, 2007) |
| "The comparative efficacy of gestational diabetes (GDM) treatments lack conclusive evidence for choice of first-line treatment." | 2.72 | Metformin is comparable to insulin for pharmacotherapy in gestational diabetes mellitus: A network meta-analysis evaluating 6046 women. ( Abou-Samra, AB; Bashir, M; Chivese, T; Clark, J; Doi, SA; Furuya-Kanamori, L; Mohamed, AM; Musa, OAH; Syed, A; Thalib, L; Toft, E; Xu, C, 2021) |
| "Maternal gestational diabetes mellitus (GDM) is one of the most common medical complications of pregnancy, which can adversely affect the short- and long-term health of mothers and newborns." | 2.72 | Gestational diabetes: Implications for fetal growth, intervention timing, and treatment options. ( Brunetti, A; Chiefari, E; Foti, D; Greco, E; Mirabelli, M; Tocci, V, 2021) |
| "Neonatal hypoglycemia was observed in eight newborns, six of which from the glyburide group." | 2.71 | Perinatal outcomes and the use of oral hypoglycemic agents. ( Aquim, G; Becker, F; Bertini, AM; Engel Ribeiro, T; Lemos Bebber, FR; Silva, JC; Taborda, W; Zucco Viesi, JM, 2005) |
| "Women with gestational diabetes mellitus are rarely treated with a sulfonylurea drug, because of concern about teratogenicity and neonatal hypoglycemia." | 2.69 | A comparison of glyburide and insulin in women with gestational diabetes mellitus. ( Berkus, MD; Conway, DL; Gonzales, O; Langer, O; Xenakis, EM, 2000) |
| "Fetal growth in gestational diabetes mellitus (GDM) is directly linked to maternal glycaemic control; however, this relationship may be altered by oral anti-hyperglycaemic agents." | 2.66 | Comparative impact of pharmacological treatments for gestational diabetes on neonatal anthropometry independent of maternal glycaemic control: A systematic review and meta-analysis. ( Aiken, CE; Ozanne, SE; Tarry-Adkins, JL, 2020) |
| "Glyburide has been associated with increased neonatal hypoglycemia." | 2.61 | The Use of Non-insulin Agents in Gestational Diabetes: Clinical Considerations in Tailoring Therapy. ( Blair, RA; Palermo, NE; Rosenberg, EA, 2019) |
| "Pregestational and gestational diabetes are associated with significant maternal and fetal risks; therefore, screening and treatment during pregnancy are recommended." | 2.61 | Pharmacologic Treatment of Diabetes in Pregnancy. ( Bishop, KC; Boyd, BK; Brown, L; Harris, BS; Kuller, JA; Reiff, ES, 2019) |
| "Metformin has also proven to be safe and may be considered as an initial single agent for milder gestational diabetes." | 2.55 | The care of pregestational and gestational diabetes and drug metabolism considerations. ( Davis, SN; Hedrington, MS, 2017) |
| "Glyburide has good efficacy and short-term data but it also crosses the placenta and may be associated with increased rates of large-for-gestational-age (LGA) infants and neonatal hypoglycaemia when compared with insulin." | 2.55 | Pharmacological Management of Gestational Diabetes Mellitus. ( Feig, DS; Mukerji, G, 2017) |
| " In areas of limited resources where the self-monitoring needed for accurate insulin dosing is not possible, where access to refrigeration for insulin storage is not universal, or severe needle phobia then the benefits of glyburide (controlling hyperglycemia) outweighs the harm of NICU admissions and macrosomia." | 2.53 | Pharmacokinetics, efficacy and safety of glyburide for treatment of gestational diabetes mellitus. ( Davis, SN; Malek, R, 2016) |
| "The primary aims of the treatment of gestational diabetes (GDM) are to prevent macrosomia and pregnancy complications." | 2.53 | Is it worth treating gestational diabetes: if so, when and how? ( Vääräsmäki, M, 2016) |
| " Other oral medications have not been shown to be safe in pregnancy." | 2.52 | Safety considerations with pharmacological treatment of gestational diabetes mellitus. ( Simmons, D, 2015) |
| "At short term, in women with gestational diabetes requiring drug treatment, glibenclamide is clearly inferior to both insulin and metformin, while metformin (plus insulin when required) performs slightly better than insulin." | 2.52 | Glibenclamide, metformin, and insulin for the treatment of gestational diabetes: a systematic review and meta-analysis. ( Balsells, M; Corcoy, R; García-Patterson, A; Gich, I; Roqué, M; Solà, I, 2015) |
| "Metformin seems to be a superior choice to glyburide if oral antidiabetic drug therapy is to be initiated in GDM patients." | 2.52 | Comparison of glyburide with metformin in treating gestational diabetes mellitus: a systematic review and meta-analysis. ( Amin, M; Malik, O; Poolsup, N; Suksomboon, N, 2015) |
| "Metformin seems to be an efficacious alternative to insulin and a better choice than glyburide especially those with mild form of disease." | 2.50 | Efficacy and safety of oral antidiabetic drugs in comparison to insulin in treating gestational diabetes mellitus: a meta-analysis. ( Amin, M; Poolsup, N; Suksomboon, N, 2014) |
| " In this article, we review the efficacy, safety, and dosage of oral hypoglycemic agents for the treatment of gestational diabetes mellitus." | 2.50 | Gestational diabetes mellitus management with oral hypoglycemic agents. ( Hays, KE; Hebert, MF; Ryu, RJ, 2014) |
| "Pregnancy is an indication for intensive insulin therapy." | 2.48 | [Drug therapy for diabetes mellitus during pregnancy and breastfeeding in the beginning of 21 century: status quo and new challenges]. ( Zhelyazkova-Savova, M, 2012) |
| " In this review, our objectives were to (1) summarise the available evidence on the efficacy these medications, (2) review available data on adverse effect, (3) discuss current gaps in research, outlining limitations in current study designs that deserve attention and (4) summarise key points for the practicing clinician." | 2.47 | Oral hypoglycaemic agents during pregnancy: The evidence for effectiveness and safety. ( Baptiste-Roberts, K; Nicholson, W, 2011) |
| "For patients with Type 2 diabetes or gestational diabetes, oral hypoglycemic agents (OHAs) represent an attractive alternative to insulin therapy." | 2.46 | Oral hypoglycemic therapy: understanding the mechanisms of transplacental transfer. ( Feig, DS; Koren, G; Pollex, EK, 2010) |
| "Women with type 2 diabetes treated with sulfonylureas should not be discouraged from breastfeeding." | 2.45 | Use of hypoglycemic drugs during lactation. ( Djokanovic, N; Finkelstein, Y; Garcia-Bournissen, F; Glatstein, MM; Koren, G, 2009) |
| "The incidence of gestational diabetes is increasing." | 2.45 | The management of gestational diabetes. ( Cheung, NW, 2009) |
| "Maternal characteristics and outcomes (preeclampsia and weight gain) and neonatal outcomes (birth weight and percentile, hypoglycemia, jaundice, and respiratory morbidity) were compared between groups." | 1.91 | Insulin Detemir Versus Glibenclamide in Gestational Diabetes Mellitus: A Retrospective Cohort Study. ( Fakterman, M; Kovo, M; Leytes, S; Ravid, D; Weitzner, O; Yagur, Y, 2023) |
| "The increased prevalence of gestational diabetes mellitus (GDM) has caused a huge societal economic and healthy burden at both the population and individual levels." | 1.72 | Comparative efficacy and safety of glyburide, metformin, and insulin in treatment of gestational diabetes mellitus: A protocol for systematic review and meta-analysis. ( Hong, XY; Lin, J; Tu, RZ, 2022) |
| "In addition, the steps in the gestational diabetes mellitus management decision path and the current cost of the use of insulin, glyburide, or metformin are addressed." | 1.48 | Pharmacological treatment of gestational diabetes mellitus: point/counterpoint. ( Langer, O, 2018) |
| "Successful rat models for preeclampsia were confirmed based on mean arterial pressure, a 24-h protein urine test, and by observing the structure of the kidney by transmission electron microscopy (TEM)." | 1.48 | Role of AKR1C3 in renal injury and glibenclamide is anti-inflammatory in preeclamptic rats. ( Jin, Y; Li, L; Liu, XW; Sun, CJ; Zhang, WY, 2018) |
| "Glyburide failure was defined as reaching glyburide 20 mg day(-1) and receiving insulin." | 1.43 | Predicting failure of glyburide therapy in gestational diabetes. ( Biggio, JR; Glover, AV; Harper, LM; Tita, A, 2016) |
| "Maternal obesity and gestational diabetes mellitus (GDM) are two increasingly common and important obstetric complications that are associated with severe long-term health risks to mothers and babies." | 1.42 | Endoplasmic reticulum stress is increased in adipose tissue of women with gestational diabetes. ( Lappas, M; Liong, S, 2015) |
| "Glyburide has replaced insulin as the more common pharmacotherapy for GDM over the past decade among those privately insured." | 1.40 | Trends in glyburide compared with insulin use for gestational diabetes treatment in the United States, 2000-2011. ( Benjamin, DK; Boggess, K; Brookhart, MA; Camelo Castillo, W; Jonsson Funk, M; Stürmer, T, 2014) |
| "Glyburide (200 ng/mL) was introduced to maternal and fetal compartments through a recirculating 2 hour perfusion, and its transplacental transport was tested with (n = 8) or without (n = 8) cannabidoil." | 1.39 | Cannabidiol enhances xenobiotic permeability through the human placental barrier by direct inhibition of breast cancer resistance protein: an ex vivo study. ( Ben-Zvi, Z; Erez, O; Eshkoli, T; Feinshtein, V; Holcberg, G; Sheiner, E; Sheizaf, B, 2013) |
| "Neonates born to women with gestational diabetes managed on glyburide, and were more likely to be macrosomic and to be admitted to the intensive care unit compared to those treated with insulin injections." | 1.38 | Treatment of gestational diabetes mellitus: glyburide compared to subcutaneous insulin therapy and associated perinatal outcomes. ( Block-Kurbisch, I; Caughey, AB; Cheng, YW; Chung, JH; Inturrisi, M, 2012) |
| "Hypoglycemia was defined as a blood glucose of less than 50 mg/dL, further classified as "severe hypoglycemia" if the event required the assistance of another person for resuscitation, "symptomatic hypoglycemia" if it was associated with typical neurogenic symptoms, or "asymptomatic hypoglycemia" if the biochemical reading was less than 50 mg/dL with no symptoms or accompanied by mild symptoms that did not impair the patient's ability to function." | 1.37 | Hypoglycemia in glyburide-treated gestational diabetes: is it dose-dependent? ( Brustman, L; El Daouk, M; Fuchs, A; Langer, O; Rosenn, B; Scarpelli, S, 2011) |
| "Glyburide and metformin have been shown to be as effective as insulin for the treatment of gestational diabetes." | 1.37 | Oral hypoglycemic agents in pregnancy. ( Refuerzo, JS, 2011) |
| "Hyperlipidemia occurs in GDM." | 1.36 | Impact of hyperlipidemia on plasma protein binding and hepatic drug transporter and metabolic enzyme regulation in a rat model of gestational diabetes. ( Anger, GJ; Piquette-Miller, M, 2010) |
| "Glyburide was transported by multidrug resistance protein (43 +/- 4%); breast cancer resistance protein (25 +/- 5%); and P-glycoprotein (9 +/- 5%)." | 1.36 | Role of human placental apical membrane transporters in the efflux of glyburide, rosiglitazone, and metformin. ( Ahmed, MS; Hankins, GD; Hemauer, SJ; Nanovskaya, TN; Patrikeeva, SL, 2010) |
| "Glyburide (GLB) is an oral sulfonylurea, commonly used for the treatment of gestational diabetes mellitus." | 1.36 | Increased glyburide clearance in the pregnant mouse model. ( Hebert, MF; Mao, Q; Unadkat, JD; Zhang, Y; Zhou, L, 2010) |
| "Glyburide, a drug used to treat gestational diabetes has previously been shown not to be measurable in fetal blood, and to be transferred from the fetal to the maternal circulation against a concentration gradient." | 1.35 | Investigating the potential role of multi-drug resistance protein (MRP) transporters in fetal to maternal glyburide efflux in the human placenta. ( Anger, G; Gedeon, C; Koren, G; Lubetsky, A; Miller, MP, 2008) |
| " However, by means of pharmacokinetic modeling we describe the inverse correlation between lipid solubility of a molecule and its active transport by placental ABC efflux transporters." | 1.35 | Transplacental pharmacokinetics of glyburide, rhodamine 123, and BODIPY FL prazosin: effect of drug efflux transporters and lipid solubility. ( Ceckova, M; Cygalova, LH; Hofman, J; Staud, F, 2009) |
| "Treatment of gestational diabetes mellitus is a hotly debated topic." | 1.35 | [Oral blood glucose-lowering medication as a monotherapy in gestational diabetes: a hotly debated topic]. ( de Valk, HW, 2009) |
| "Glyburide was detected at 254 nm, with a total run time of 7 min per sample." | 1.35 | A simple and rapid HPLC method for the detection of glyburide in plasma original research communication (analytical). ( Aleksa, K; Gedeon, C; Kapur, B; Koren, G, 2008) |
| "Glyburide (GLB) is an antidiabetic drug routinely used to treat gestational diabetes." | 1.35 | The breast cancer resistance protein (Bcrp1/Abcg2) limits fetal distribution of glyburide in the pregnant mouse: an Obstetric-Fetal Pharmacology Research Unit Network and University of Washington Specialized Center of Research Study. ( Hebert, MF; Mao, Q; Naraharisetti, SB; Unadkat, JD; Wang, H; Zhou, L, 2008) |
| "Glyburide is a second-generation sulfonylurea hypoglycemic drug used for the treatment of select women with pregestational and gestational diabetes mellitus (GDM)." | 1.33 | Effect of human serum albumin on transplacental transfer of glyburide. ( Ahmed, MS; Hankins, GD; Nanovskaya, TN; Nekhayeva, I, 2006) |
| "The glyburide failure rate was calculated and factors that might predict success with glyburide were analyzed between the success and failure groups using chi(2) or Student'st-tests." | 1.32 | Prospective observational study to establish predictors of glyburide success in women with gestational diabetes mellitus. ( Chmait, R; Dinise, T; Moore, T, 2004) |
| "Approximately 80% of patients with gestational diabetes who fail to respond to diet therapy can be treated effectively with glyburide." | 1.32 | Glyburide for the treatment of gestational diabetes. ( Duff, P; Kremer, CJ, 2004) |
| "An evaluation of 82 patients with gestational diabetes was performed; 30 were insulin-treated, 27 were managed by diet only, and 25 were patients treated with glyburide." | 1.32 | Undiagnosed asymptomatic hypoglycemia: diet, insulin, and glyburide for gestational diabetic pregnancy. ( Ben-Haroush, A; Chen, R; Hod, M; Langer, O; Rosenn, B; Yogev, Y, 2004) |
| "Quite a few of my patients experience gestational diabetes." | 1.32 | Breakthrough in treating gestational diabetes mellitus. ( Koren, G, 2004) |
| "Sevoflurane responses were repeated at concentrations with no effect on spontaneous contractility of TEA, a Ca(2+)-activated K(+) channel blocker, and glibenclamide, an adenosine triphosphate-sensitive K(+) channel blocker, in myometrial strips." | 1.31 | The role of K(+) channels on the inhibitor effect of sevoflurane in pregnant rat myometrium. ( Bagcivan, I; Gürsoy, S; Kafali, H; Karadas, B; Kaya, T; Sarioglu, Y, 2002) |
| "The pregnancy outcome of 33 women with gestational diabetes who were treated with glibenclamide and changed to insulin if glibenclamide failed, were compared with the pregnancy outcome of 21 women with gestational diabetes treated conventionally with insulin." | 1.30 | A comparison between the pregnancy outcome of women with gestation diabetes treated with glibenclamide and those treated with insulin. ( Lim, JM; O'Brien, PM; Shaw, RW; Tayob, Y, 1997) |
| "Aprikalim and BRL 38227 were also potent relaxants of oxytocin (1 nmol/L)-induced contractions with rapid onset of action, of similar potency to each other, and reversible." | 1.29 | Inhibition of contractions of the isolated human myometrium by potassium channel openers. ( Cheuk, JM; Hollingsworth, M; Hughes, SJ; Maresh, MJ; Piper, IT, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (4.37) | 18.7374 |
| 1990's | 22 (8.73) | 18.2507 |
| 2000's | 81 (32.14) | 29.6817 |
| 2010's | 106 (42.06) | 24.3611 |
| 2020's | 32 (12.70) | 2.80 |
| Authors | Studies |
|---|---|
| Venkatesh, KK | 1 |
| Chiang, CW | 1 |
| Castillo, WC | 2 |
| Battarbee, AN | 1 |
| Donneyong, M | 1 |
| Harper, LM | 3 |
| Costantine, M | 1 |
| Saade, G | 1 |
| Werner, EF | 1 |
| Boggess, KA | 2 |
| Landon, MB | 3 |
| Yu, DQ | 1 |
| Xu, GX | 1 |
| Teng, XY | 1 |
| Xu, JW | 1 |
| Tang, LF | 1 |
| Feng, C | 1 |
| Rao, JP | 1 |
| Jin, M | 1 |
| Wang, LQ | 1 |
| Wang, C | 1 |
| Ma, D | 1 |
| Hua, Y | 1 |
| Duan, H | 1 |
| Palatnik, A | 2 |
| Harrison, RK | 2 |
| Thakkar, MY | 1 |
| Walker, RJ | 1 |
| Egede, LE | 1 |
| Li, C | 2 |
| Gao, C | 1 |
| Zhang, X | 2 |
| Zhang, L | 1 |
| Shi, H | 1 |
| Jia, X | 1 |
| Paventi, G | 1 |
| Soldovieri, MV | 1 |
| Servettini, I | 1 |
| Barrese, V | 1 |
| Miceli, F | 1 |
| Sisalli, MJ | 1 |
| Ambrosino, P | 1 |
| Mosca, I | 1 |
| Vinciguerra, I | 1 |
| Testai, L | 1 |
| Scorziello, A | 1 |
| Raimo, G | 1 |
| Calderone, V | 1 |
| Passarella, S | 1 |
| Taglialatela, M | 1 |
| Saravanan, V | 1 |
| Davitt, C | 1 |
| Cruz, M | 1 |
| Oliveira, MM | 1 |
| Andrade, KFO | 1 |
| Lima, GHS | 1 |
| Rocha, TC | 1 |
| Lin, J | 1 |
| Tu, RZ | 1 |
| Hong, XY | 1 |
| Hedderson, MM | 1 |
| Badon, SE | 1 |
| Pimentel, N | 1 |
| Xu, F | 1 |
| Regenstein, A | 1 |
| Ferrara, A | 2 |
| Neugebauer, R | 1 |
| Mehta, D | 1 |
| Li, M | 1 |
| Nakamura, N | 1 |
| Chidambaram, M | 1 |
| He, X | 1 |
| Bryant, MS | 1 |
| Patton, R | 1 |
| Davis, K | 1 |
| Fisher, J | 1 |
| Walton-Betancourth, S | 1 |
| Ashford, J | 1 |
| Beardsall, K | 1 |
| Gooding, N | 1 |
| Gurnell, EM | 1 |
| Hendriks, E | 1 |
| Hysted, H | 1 |
| Lee, J | 2 |
| Thankamony, A | 1 |
| Tseretopoulou, X | 1 |
| Win, M | 1 |
| Williams, RM | 1 |
| Pilszyk, A | 1 |
| Niebrzydowska, M | 1 |
| Pilszyk, Z | 1 |
| Wierzchowska-Opoka, M | 1 |
| Kimber-Trojnar, Ż | 2 |
| Wang, T | 1 |
| Jing, Y | 1 |
| Guo, H | 1 |
| Xu, J | 1 |
| Wang, M | 1 |
| Huang, L | 1 |
| Chen, H | 2 |
| Cui, W | 1 |
| Song, L | 1 |
| Liu, X | 1 |
| Sun, B | 1 |
| Wang, N | 1 |
| Rickert, M | 1 |
| Caughey, AB | 4 |
| Valent, AM | 1 |
| Prozorova, TM | 1 |
| Zhulkevych, IV | 1 |
| Andreychyn, SM | 1 |
| Korylchuk, NI | 1 |
| Hanberher, II | 1 |
| Riabokon, SS | 1 |
| Kamyshnyi, AM | 1 |
| Ravid, D | 1 |
| Kovo, M | 1 |
| Leytes, S | 1 |
| Yagur, Y | 1 |
| Fakterman, M | 1 |
| Weitzner, O | 1 |
| de Wit, L | 1 |
| Rademaker, D | 1 |
| Voormolen, DN | 1 |
| Akerboom, BMC | 1 |
| Kiewiet-Kemper, RM | 1 |
| Soeters, MR | 1 |
| Verwij-Didden, MAL | 1 |
| Assouiki, F | 1 |
| Schippers, DH | 1 |
| Vermeulen, MAR | 1 |
| Kuppens, SMI | 1 |
| Oosterwerff, MM | 1 |
| Zwart, JJ | 1 |
| Diekman, MJM | 1 |
| Vogelvang, TE | 1 |
| Gallas, PRJ | 1 |
| Galjaard, S | 1 |
| Visser, W | 1 |
| Horree, N | 1 |
| Klooker, TK | 1 |
| Laan, R | 1 |
| Heijligenberg, R | 1 |
| Huisjes, AJM | 1 |
| van Bemmel, T | 1 |
| van Meir, CA | 1 |
| van den Beld, AW | 1 |
| Hermes, W | 1 |
| Vidarsdottir, S | 1 |
| Veldhuis-Vlug, AG | 1 |
| Dullemond, RC | 1 |
| Jansen, HJ | 1 |
| Sueters, M | 1 |
| de Koning, EJP | 1 |
| van Laar, JOEH | 1 |
| Wouters-van Poppel, P | 1 |
| Sanson-van Praag, ME | 1 |
| van den Akker, ES | 1 |
| Brouwer, CB | 1 |
| Hermsen, BB | 1 |
| Potter van Loon, BJ | 1 |
| van der Heijden, OWH | 1 |
| de Galan, BE | 1 |
| van Leeuwen, M | 1 |
| Wijbenga, JAM | 1 |
| de Boer, K | 1 |
| van Bon, AC | 1 |
| van der Made, FW | 1 |
| Eskes, SA | 1 |
| Zandstra, M | 1 |
| van Houtum, WH | 1 |
| Braams-Lisman, BAM | 1 |
| Daemen-Gubbels, CRGM | 1 |
| Wouters, MGAJ | 1 |
| IJzerman, RG | 1 |
| Mensing van Charante, NA | 1 |
| Zwertbroek, R | 1 |
| Bosmans, JE | 1 |
| Evers, IM | 1 |
| Mol, BW | 1 |
| de Valk, HW | 2 |
| Groenendaal, F | 1 |
| Naaktgeboren, CA | 1 |
| Painter, RC | 1 |
| deVries, JH | 1 |
| Franx, A | 1 |
| van Rijn, BB | 1 |
| Mott, K | 1 |
| Reichman, ME | 1 |
| Toh, S | 1 |
| Kieswetter, C | 1 |
| Haffenreffer, K | 1 |
| Andrade, SE | 1 |
| Guo, L | 1 |
| Ma, J | 1 |
| Tang, J | 2 |
| Hu, D | 1 |
| Zhang, W | 1 |
| Zhao, X | 1 |
| Blair, RA | 1 |
| Rosenberg, EA | 1 |
| Palermo, NE | 1 |
| Shuster, DL | 2 |
| Shireman, LM | 1 |
| Ma, X | 2 |
| Shen, DD | 2 |
| Flood Nichols, SK | 1 |
| Ahmed, MS | 9 |
| Clark, S | 1 |
| Caritis, S | 2 |
| Venkataramanan, R | 1 |
| Haas, DM | 1 |
| Quinney, SK | 1 |
| Haneline, LS | 1 |
| Tita, AT | 1 |
| Manuck, TA | 1 |
| Thummel, KE | 2 |
| Brown, LM | 1 |
| Ren, Z | 1 |
| Brown, Z | 1 |
| Easterling, TR | 3 |
| Hebert, MF | 8 |
| Helal, KF | 1 |
| Badr, MS | 1 |
| Rafeek, ME | 1 |
| Elnagar, WM | 1 |
| Lashin, ME | 1 |
| Lawal, SK | 1 |
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| Sulaiman, SO | 1 |
| Akajewole, MM | 1 |
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| Osinubi, AA | 1 |
| Bouchghoul, H | 3 |
| Alvarez, JC | 1 |
| Verstuyft, C | 2 |
| Bouyer, J | 5 |
| Senat, MV | 5 |
| Tarry-Adkins, JL | 1 |
| Aiken, CE | 1 |
| Ozanne, SE | 1 |
| Lofthouse, EM | 1 |
| Cleal, JK | 1 |
| Hudson, G | 1 |
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| Sengers, BG | 1 |
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| Barak, L | 1 |
| Dankovcikova, A | 1 |
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| Funk, MJ | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparative Studies of Metformin and Insulin on Stereological Studies and Immunohistochemistry of Placenta[NCT04907708] | 156 participants (Actual) | Interventional | 2018-01-01 | Completed | |||
| A Feasibility Study Looking at the Use of Glibenclamide and metfoRmin Versus stAndard Care in gEstational diabeteS[NCT02080377] | Phase 3 | 23 participants (Actual) | Interventional | 2014-07-31 | Completed | ||
| Multicenter Randomized Trial of Non-inferiority Between Glyburide and Insulin for the Treatment of Gestational Diabetes[NCT01731431] | Phase 3 | 914 participants (Actual) | Interventional | 2012-05-18 | Completed | ||
| [NCT01947699] | Phase 4 | 0 participants (Actual) | Interventional | 2013-09-30 | Withdrawn (stopped due to PI decided to withdrawal study before recruitment started) | ||
| Glyburide and Metformin for the Treatment of Gestational Diabetes Mellitus. A Systematic Review and Meta-analysis of Randomized Controlled Trials Comparing These Drugs Either vs Insulin or vs Each Other.[NCT01998113] | 2,509 participants (Actual) | Observational | 2013-03-31 | Completed | |||
| Effect of Metformin on Healthy Live Birth After In-vitro Fertilization in Women With Prediabetes Mellitus: a Multicenter Double-blind Placebo Controlled Randomized Trial[NCT06064669] | 988 participants (Anticipated) | Interventional | 2023-10-01 | Not yet recruiting | |||
| A Randomized Controlled Clinical Trial of Treatment of Mild Gestational Diabetes With Glyburide Versus Placebo[NCT00744965] | Phase 4 | 395 participants (Actual) | Interventional | 2008-09-16 | Completed | ||
| [NCT01563120] | Phase 4 | 108 participants (Actual) | Interventional | 2012-01-31 | Completed | ||
| Study of Awareness of Gestational Diabetes Problem Among Sohag Governorate Women[NCT05148897] | 500 participants (Anticipated) | Observational [Patient Registry] | 2021-10-01 | Recruiting | |||
| A Randomized Prospective Trial of Metformin Compared to Glyburide in Gestational Diabetes[NCT00965991] | 149 participants (Actual) | Interventional | 2003-07-31 | Completed | |||
| Glyburide vs Glucovance in the Treatment of Gestational Diabetes[NCT02726490] | Early Phase 1 | 7 participants (Actual) | Interventional | 2016-07-31 | Terminated (stopped due to Lack of Recruitment) | ||
| Effects of Choline Supplementation on Fetal Growth in Gestational Diabetes Mellitus[NCT04302168] | 60 participants (Anticipated) | Interventional | 2020-04-01 | Recruiting | |||
| Pulsatile GnRH in Anovulatory Infertility[NCT00383656] | Phase 2 | 270 participants (Anticipated) | Interventional | 1989-01-31 | Recruiting | ||
| Non-inferiority Between Acarbose and Prandial Insulin for the Treatment of Gestational Diabetes Mellitus: a Randomized Multicenter and Prospective Trial. ACARB-GDM Study.[NCT03380546] | Phase 3 | 341 participants (Actual) | Interventional | 2018-07-04 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT00744965)
Timeframe: at delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Placebo | 5 |
| Glyburide | 1 |
Maternal fever >=38.0°C (NCT00744965)
Timeframe: intrapartum
| Intervention | Participants (Count of Participants) |
|---|---|
| Placebo | 12 |
| Glyburide | 15 |
(NCT00744965)
Timeframe: until hospital discharge
| Intervention | Participants (Count of Participants) |
|---|---|
| Placebo | 12 |
| Glyburide | 15 |
birth weight 4,000 g or greater (NCT00744965)
Timeframe: After delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Placebo | 18 |
| Glyburide | 13 |
(NCT00744965)
Timeframe: Immediately after delivery of fetus
| Intervention | grams (Mean) |
|---|---|
| Placebo | 3355 |
| Glyburide | 3322 |
(NCT00744965)
Timeframe: throughout pregnancy and delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Placebo | 4 |
| Glyburide | 4 |
(NCT00744965)
Timeframe: after delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Placebo | 4 |
| Glyburide | 4 |
(NCT00744965)
Timeframe: Until hospital discharge
| Intervention | Participants (Count of Participants) |
|---|---|
| Placebo | 11 |
| Glyburide | 13 |
Birth weight exceeding the 90th percentile for the gestational age at delivery. (NCT00744965)
Timeframe: After delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Placebo | 22 |
| Glyburide | 20 |
(NCT00744965)
Timeframe: After delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Placebo | 67 |
| Glyburide | 70 |
(NCT00744965)
Timeframe: at delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Placebo | 1 |
| Glyburide | 0 |
The importance of exercise in the management of blood glucose was emphasized, and 30 minutes of walking per day was recommended. Patients received instruction from a nurse educator or a certified diabetes educator regarding diet and the use of the glucometer. Number of participants with a glucose level <100 mg/dL. (NCT00965991)
Timeframe: fasting and 2 hour postprandial blood glucose
| Intervention | Participants (Count of Participants) |
|---|---|
| Metformin | 50 |
| Glyburide | 50 |
67 reviews available for glyburide and Pregnancy
| Article | Year |
|---|---|
Glycemic control and neonatal outcomes in women with gestational diabetes mellitus treated using glyburide, metformin, or insulin: a pairwise and network meta-analysis.
Topics: Adult; Blood Glucose; Diabetes, Gestational; Female; Glyburide; Glycemic Control; Humans; Hypoglycem | 2021 |
Comparison of the effectiveness and safety of insulin and oral hypoglycemic drugs in the treatment of gestational diabetes mellitus: a meta-analysis of 26 randomized controlled trials.
Topics: Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Infant, Newborn; Insulin; Met | 2022 |
Metformin versus glyburide in treatment and control of gestational diabetes mellitus: a systematic review with meta-analysis.
Topics: Blood Glucose; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Infant, Newbor | 2022 |
Incretins as a Potential Treatment Option for Gestational Diabetes Mellitus.
Topics: Blood Glucose; Diabetes Mellitus, Type 2; Diabetes, Gestational; Dipeptidyl-Peptidase IV Inhibitors; | 2022 |
Medications for Managing Preexisting and Gestational Diabetes in Pregnancy.
Topics: Child; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Insulin; Metformin; Pr | 2023 |
Comparative Efficacy and Safety of Metformin, Glyburide, and Insulin in Treating Gestational Diabetes Mellitus: A Meta-Analysis.
Topics: Adult; Biomarkers; Blood Glucose; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Age | 2019 |
The Use of Non-insulin Agents in Gestational Diabetes: Clinical Considerations in Tailoring Therapy.
Topics: Acarbose; Diabetes, Gestational; Female; Glyburide; Healthy Lifestyle; Humans; Hypoglycemic Agents; | 2019 |
Can glyburide be advocated over subcutaneous insulin for perinatal outcomes of women with gestational diabetes? A systematic review and meta-analysis.
Topics: Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Infusions, Subcutaneous; Insu | 2020 |
Comparative impact of pharmacological treatments for gestational diabetes on neonatal anthropometry independent of maternal glycaemic control: A systematic review and meta-analysis.
Topics: Anthropometry; Birth Weight; Blood Glucose; Diabetes, Gestational; Female; Fetal Macrosomia; Glyburi | 2020 |
Gestational Diabetes Mellitus Pharmacological Prevention and Treatment.
Topics: Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Insulin; Metformin; Pregnancy | 2021 |
Metformin is comparable to insulin for pharmacotherapy in gestational diabetes mellitus: A network meta-analysis evaluating 6046 women.
Topics: Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Insulin; Metformin; Pregnancy | 2021 |
Comparison of Insulin, Metformin, and Glyburide on Perinatal Complications of Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis.
Topics: Cesarean Section; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Infant, New | 2021 |
Effectiveness of antidiabetic agents for treatment of gestational diabetes: A methodological quality assessment of meta-analyses and network meta-analysis.
Topics: Adult; Blood Glucose; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Infant, | 2021 |
Gestational diabetes: Implications for fetal growth, intervention timing, and treatment options.
Topics: Diabetes, Gestational; Female; Fetal Development; Glyburide; Humans; Hypoglycemic Agents; Infant, Ne | 2021 |
Treatments for gestational diabetes: a systematic review and meta-analysis.
Topics: Bayes Theorem; Cesarean Section; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agen | 2017 |
Comparison of glyburide and insulin in the management of gestational diabetes: A meta-analysis.
Topics: Adult; Birth Weight; Diabetes, Gestational; Disease Management; Female; Glyburide; Humans; Hypoglyce | 2017 |
The care of pregestational and gestational diabetes and drug metabolism considerations.
Topics: Animals; Blood Glucose; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemia; Hypoglycemic | 2017 |
Pharmacological Management of Gestational Diabetes Mellitus.
Topics: Acarbose; Blood Glucose; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemia; Hypoglycemi | 2017 |
Comparative efficacy and safety of oral antidiabetic drugs and insulin in treating gestational diabetes mellitus: An updated PRISMA-compliant network meta-analysis.
Topics: Administration, Oral; Adult; Blood Glucose; Comparative Effectiveness Research; Diabetes, Gestationa | 2017 |
Metformin for prevention of hypertensive disorders of pregnancy in women with gestational diabetes or obesity: systematic review and meta-analysis of randomized trials.
Topics: Bayes Theorem; Diabetes, Gestational; Female; Glyburide; Humans; Hypertension, Pregnancy-Induced; In | 2018 |
Oral Agents for the Treatment of Gestational Diabetes.
Topics: Administration, Oral; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Insulin | 2018 |
Pharmacologic Treatment of Diabetes in Pregnancy.
Topics: Diabetes, Gestational; Exercise; Female; Glyburide; Humans; Hypoglycemic Agents; Insulin; Metformin; | 2019 |
Oral agents for the management of gestational diabetes.
Topics: Administration, Oral; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Metform | 2013 |
Is glyburide safe in pregnancy?
Topics: Animals; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Maternal-Fetal Excha | 2014 |
The use of glyburide in the management of gestational diabetes mellitus: a meta-analysis.
Topics: Birth Weight; Blood Glucose; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; | 2014 |
Unresolved controversies in gestational diabetes: implications on maternal and infant health.
Topics: Caloric Restriction; Diabetes, Gestational; Diet, Carbohydrate-Restricted; Diet, Diabetic; Female; F | 2014 |
Efficacy and safety of oral antidiabetic drugs in comparison to insulin in treating gestational diabetes mellitus: a meta-analysis.
Topics: Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Insulin; Metformin; Pregnancy | 2014 |
Gestational diabetes mellitus management with oral hypoglycemic agents.
Topics: Administration, Oral; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Insulin | 2014 |
Screening and management of gestational diabetes.
Topics: Blood Glucose; Blood Glucose Self-Monitoring; Diabetes Mellitus, Type 2; Diabetes, Gestational; Diet | 2015 |
Safety considerations with pharmacological treatment of gestational diabetes mellitus.
Topics: Animals; Blood Glucose; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemia; Hypoglycemic | 2015 |
Glibenclamide, metformin, and insulin for the treatment of gestational diabetes: a systematic review and meta-analysis.
Topics: Adult; Birth Weight; Diabetes, Gestational; Female; Fetal Macrosomia; Glyburide; Humans; Hypoglycemi | 2015 |
Glibenclamide, metformin, and insulin for the treatment of gestational diabetes: a systematic review and meta-analysis.
Topics: Adult; Birth Weight; Diabetes, Gestational; Female; Fetal Macrosomia; Glyburide; Humans; Hypoglycemi | 2015 |
Glibenclamide, metformin, and insulin for the treatment of gestational diabetes: a systematic review and meta-analysis.
Topics: Adult; Birth Weight; Diabetes, Gestational; Female; Fetal Macrosomia; Glyburide; Humans; Hypoglycemi | 2015 |
Glibenclamide, metformin, and insulin for the treatment of gestational diabetes: a systematic review and meta-analysis.
Topics: Adult; Birth Weight; Diabetes, Gestational; Female; Fetal Macrosomia; Glyburide; Humans; Hypoglycemi | 2015 |
Using oral agents to manage gestational diabetes: what have we learned?
Topics: Acarbose; Administration, Oral; Birth Weight; Diabetes, Gestational; Female; Glyburide; Humans; Hypo | 2015 |
Comparative efficacy and safety of OADs in management of GDM: network meta-analysis of randomized controlled trials.
Topics: Administration, Oral; Blood Glucose; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic | 2015 |
Comparison of glyburide with metformin in treating gestational diabetes mellitus: a systematic review and meta-analysis.
Topics: Adult; Birth Weight; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Infant, | 2015 |
Pharmacokinetics, efficacy and safety of glyburide for treatment of gestational diabetes mellitus.
Topics: Animals; Blood Glucose; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Infan | 2016 |
Is it worth treating gestational diabetes: if so, when and how?
Topics: Blood Glucose; Diabetes, Gestational; Female; Glyburide; Humans; Metformin; Pregnancy; Pregnancy Com | 2016 |
Pharmacological Management of Gestational Diabetes Mellitus.
Topics: Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Insulin; Metformin; Pregnancy | 2016 |
Oral anti-diabetic pharmacological therapies for the treatment of women with gestational diabetes.
Topics: Acarbose; Administration, Oral; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemia; Hypo | 2017 |
Benefits and risks of oral diabetes agents compared with insulin in women with gestational diabetes: a systematic review.
Topics: Acarbose; Administration, Oral; Birth Weight; Diabetes, Gestational; Female; Glyburide; Humans; Hypo | 2009 |
Use of hypoglycemic drugs during lactation.
Topics: Administration, Oral; Breast Feeding; Diabetes Mellitus, Type 2; Drug-Related Side Effects and Adver | 2009 |
The management of gestational diabetes.
Topics: Administration, Oral; Blood Glucose; Blood Glucose Self-Monitoring; Diabetes, Gestational; Drug Admi | 2009 |
The use of oral antidiabetic medications in gestational diabetes mellitus.
Topics: Administration, Oral; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Metform | 2009 |
Can pregnant diabetics be treated with glyburide?
Topics: Diabetes, Gestational; Drug Therapy, Combination; Female; Glyburide; Humans; Hypoglycemic Agents; In | 2009 |
Oral hypoglycemic therapy: understanding the mechanisms of transplacental transfer.
Topics: Administration, Oral; Biological Transport; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female | 2010 |
[Treatment of gestational diabetes with oral hypoglycemic agents].
Topics: Diabetes, Gestational; Female; Fetal Macrosomia; Glucose Tolerance Test; Glyburide; Humans; Hypoglyc | 2010 |
The glyburide report card.
Topics: Blood Glucose; Cohort Studies; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents | 2010 |
Oral hypoglycemic agents vs insulin in management of gestational diabetes: a systematic review and metaanalysis.
Topics: Blood Glucose; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Insulin; Metfo | 2010 |
Oral hypoglycemic agents for gestational diabetes mellitus?
Topics: Administration, Oral; Animals; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents | 2011 |
Oral hypoglycaemic agents during pregnancy: The evidence for effectiveness and safety.
Topics: Acarbose; Administration, Oral; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agent | 2011 |
Management of diabetes in pregnancy.
Topics: Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Glyburide; Huma | 2012 |
What is new in diabetes?: best articles from the past year.
Topics: Body Weight; Cholesterol, HDL; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Glyburide; | 2012 |
[Drug therapy for diabetes mellitus during pregnancy and breastfeeding in the beginning of 21 century: status quo and new challenges].
Topics: Breast Feeding; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Insulins; Met | 2012 |
Abnormal glucose metabolism: diagnosis and management in the ambulatory setting.
Topics: Ambulatory Care; Blood Glucose Self-Monitoring; Diabetes, Gestational; Diet Therapy; Exercise Therap | 2012 |
[Medical management of pregnant women with diabetes].
Topics: Blood Glucose; Body Weight; Congenital Abnormalities; Diabetic Nephropathies; Diabetic Retinopathy; | 2002 |
The contentious nature of gestational diabetes: diet, insulin, glyburide and metformin.
Topics: Clinical Trials as Topic; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Glyburide; Human | 2002 |
Current controversies in the mechanisms and treatment of gestational diabetes.
Topics: Autoimmune Diseases; Blood Glucose; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic A | 2002 |
Management of gestational diabetes: pharmacologic treatment options and glycemic control.
Topics: Administration, Oral; Blood Glucose; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic | 2006 |
Gestational diabetes management: guidelines to a healthy pregnancy.
Topics: Diabetes Mellitus, Type 2; Diabetes, Gestational; Diet, Diabetic; Estrogens; Exercise; Female; Fetal | 2006 |
Pharmacological management of gestational diabetes: an overview.
Topics: Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Metformin; Pregnancy | 2007 |
Glyburide for the treatment of gestational diabetes. A critical appraisal.
Topics: Administration, Oral; Case-Control Studies; Diabetes, Gestational; Female; Glyburide; Humans; Hypogl | 2007 |
Diagnosis and new approaches in the therapy of gestational diabetes mellitus.
Topics: Blood Glucose; Diabetes, Gestational; Female; Fetal Development; Fetus; Glyburide; Humans; Hypoglyce | 2006 |
Safety of glyburide for gestational diabetes: a meta-analysis of pregnancy outcomes.
Topics: Congenital Abnormalities; Diabetes, Gestational; Female; Fetal Blood; Fetal Macrosomia; Glyburide; H | 2008 |
Therapeutic management, delivery, and postpartum risk assessment and screening in gestational diabetes.
Topics: Birth Weight; Blood Glucose; Cesarean Section; Diabetes, Gestational; Female; Fetal Macrosomia; Glyb | 2008 |
Post-prandial hyperglycemia and its implications in pregnancy and lipid abnormalities.
Topics: Female; Glyburide; Humans; Hyperglycemia; Hyperlipidemias; Hypoglycemic Agents; Postprandial Period; | 2001 |
Critical appraisal of published research evidence: treatment of gestational diabetes.
Topics: Attitude of Health Personnel; Clinical Trials as Topic; Diabetes, Gestational; Evidence-Based Medici | 2001 |
Oral hypoglycemic agents and the pregnant diabetic: "from bench to bedside".
Topics: Diabetes Mellitus, Type 2; Diabetes, Gestational; Evidence-Based Medicine; Female; Glyburide; Humans | 2002 |
Glibenclamide: a review.
Topics: Administration, Oral; Adolescent; Adult; Aged; Animals; Biguanides; Blood Glucose; Carbon Isotopes; | 1971 |
22 trials available for glyburide and Pregnancy
| Article | Year |
|---|---|
SUGAR-DIP trial: oral medication strategy versus insulin for diabetes in pregnancy, study protocol for a multicentre, open-label, non-inferiority, randomised controlled trial.
Topics: Administration, Oral; Blood Glucose; Cost-Benefit Analysis; Diabetes, Gestational; Drug Therapy, Com | 2019 |
Pharmacodynamics of Glyburide, Metformin, and Glyburide/Metformin Combination Therapy in the Treatment of Gestational Diabetes Mellitus.
Topics: Adolescent; Adult; Blood Glucose; Diabetes, Gestational; Drug Therapy, Combination; Female; Glyburid | 2020 |
Transplacental transfer of glyburide in women with gestational diabetes and neonatal hypoglycemia risk.
Topics: Administration, Oral; Adult; Diabetes, Gestational; Dose-Response Relationship, Drug; Female; Fetal | 2020 |
Glyburide therapy for gestational diabetes: Glycaemic control, maternal hypoglycaemia, and treatment failure.
Topics: Diabetes, Gestational; Female; Glyburide; Glycemic Control; Humans; Hypoglycemia; Hypoglycemic Agent | 2021 |
Hypoglycemia and Glycemic Control With Glyburide in Women With Gestational Diabetes and Genetic Variants of Cytochrome P450 2C9 and/or OATP1B3.
Topics: Adult; Cytochrome P-450 CYP2C9; Diabetes, Gestational; Dose-Response Relationship, Drug; Female; Gen | 2021 |
Glibenclamide and metfoRmin versus stAndard care in gEstational diabeteS (GRACES): a feasibility open label randomised trial.
Topics: Adult; Blood Glucose; Diabetes, Gestational; Drug Therapy, Combination; Feasibility Studies; Female; | 2017 |
Effect of Glyburide vs Subcutaneous Insulin on Perinatal Complications Among Women With Gestational Diabetes: A Randomized Clinical Trial.
Topics: Administration, Oral; Adult; Blood Glucose; Diabetes, Gestational; Female; Fetal Macrosomia; Glyburi | 2018 |
Glyburide as treatment option for gestational diabetes mellitus.
Topics: Adult; Diabetes, Gestational; Female; Fetal Diseases; Glyburide; Humans; Hypoglycemic Agents; Insuli | 2013 |
Comparison of neonatal outcomes in women with gestational diabetes with moderate hyperglycaemia on metformin or glibenclamide--a randomised controlled trial.
Topics: Adult; Birth Injuries; Birth Weight; Diabetes, Gestational; Female; Fetal Macrosomia; Glyburide; Hum | 2015 |
Comparison of glyburide and insulin in women with gestational diabetes mellitus and associated perinatal outcome: a randomized clinical trial.
Topics: Adolescent; Adult; Blood Glucose; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemia; Hy | 2015 |
Glyburide in Women With Mild Gestational Diabetes: A Randomized Controlled Trial.
Topics: Adult; Blood Glucose; Diabetes, Gestational; Diet, Diabetic; Drug Monitoring; Female; Glucose Tolera | 2015 |
Glyburide Versus Metformin and Their Combination for the Treatment of Gestational Diabetes Mellitus: A Randomized Controlled Study.
Topics: Administration, Oral; Adolescent; Adult; Blood Glucose; Diabetes, Gestational; Drug Therapy, Combina | 2017 |
Are we optimizing gestational diabetes treatment with glyburide? The pharmacologic basis for better clinical practice.
Topics: Adult; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Blood Glucose; Cytochrome P-450 CYP2C9; Diab | 2009 |
Neonatal adiposity following maternal treatment of gestational diabetes with glyburide compared with insulin.
Topics: Adipose Tissue; Adult; Birth Weight; Body Composition; Body Size; Diabetes, Gestational; Female; Fet | 2009 |
Metformin compared with glyburide in gestational diabetes: a randomized controlled trial.
Topics: Adult; Blood Glucose; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Metform | 2010 |
Metformin compared with glyburide in gestational diabetes: a randomized controlled trial.
Topics: Adult; Blood Glucose; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Metform | 2010 |
Metformin compared with glyburide in gestational diabetes: a randomized controlled trial.
Topics: Adult; Blood Glucose; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Metform | 2010 |
Metformin compared with glyburide in gestational diabetes: a randomized controlled trial.
Topics: Adult; Blood Glucose; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Metform | 2010 |
Metformin compared with glyburide for the management of gestational diabetes.
Topics: Birth Weight; Blood Glucose; Diabetes, Gestational; Fasting; Female; Glyburide; Glycated Hemoglobin; | 2010 |
Perinatal impact of the use of metformin and glyburide for the treatment of gestational diabetes mellitus.
Topics: Adult; Birth Weight; Blood Glucose; Diabetes, Gestational; Female; Glucose Tolerance Test; Glyburide | 2012 |
Perinatal outcomes and the use of oral hypoglycemic agents.
Topics: Acarbose; Administration, Oral; Adult; Birth Weight; Blood Glucose; Diabetes, Gestational; Female; F | 2005 |
A prospective study comparing insulin and glibenclamide in gestational diabetes mellitus in Asian Indian women.
Topics: Adult; Diabetes, Gestational; Female; Glyburide; Humans; India; Insulin; Pregnancy | 2007 |
[Glibenclamide in the treatment for gestational diabetes mellitus in a compared study to insulin].
Topics: Adult; Birth Weight; Blood Glucose; Chi-Square Distribution; Diabetes, Gestational; Drug Therapy, Co | 2007 |
A comparison of glyburide and insulin in women with gestational diabetes mellitus.
Topics: Adolescent; Adult; Blood Glucose; Congenital Abnormalities; Diabetes, Gestational; Female; Fetal Blo | 2000 |
A comparison of glyburide and insulin in women with gestational diabetes mellitus.
Topics: Adolescent; Adult; Blood Glucose; Congenital Abnormalities; Diabetes, Gestational; Female; Fetal Blo | 2000 |
A comparison of glyburide and insulin in women with gestational diabetes mellitus.
Topics: Adolescent; Adult; Blood Glucose; Congenital Abnormalities; Diabetes, Gestational; Female; Fetal Blo | 2000 |
A comparison of glyburide and insulin in women with gestational diabetes mellitus.
Topics: Adolescent; Adult; Blood Glucose; Congenital Abnormalities; Diabetes, Gestational; Female; Fetal Blo | 2000 |
[Gestational diabetes: an alternative to insulin therapy?].
Topics: Adult; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Insulin; Pregnancy | 2001 |
163 other studies available for glyburide and Pregnancy
| Article | Year |
|---|---|
Changing patterns in medication prescription for gestational diabetes during a time of guideline change in the USA: a cross-sectional study.
Topics: Adolescent; Adult; Cross-Sectional Studies; Diabetes, Gestational; Drug Prescriptions; Female; Glybu | 2022 |
Modulation of Placental Breast Cancer Resistance Protein by HDAC1 in Mice: Implications for Optimization of Pharmacotherapy During Pregnancy.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; Female; Gene Silencing; Glyburide; | 2021 |
Correlates of Insulin Selection as a First-Line Pharmacological Treatment for Gestational Diabetes.
Topics: Administration, Oral; Adult; Analysis of Variance; Blood Glucose; Diabetes, Gestational; Female; Gly | 2022 |
Kv7.4 channels regulate potassium permeability in neuronal mitochondria.
Topics: Animals; Cells, Cultured; CHO Cells; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Femal | 2022 |
Antenatal maternal hypoglycemia in women with gestational diabetes mellitus and neonatal outcomes.
Topics: Diabetes, Gestational; Female; Fetal Macrosomia; Glyburide; Humans; Hypoglycemia; Hypoglycemic Agent | 2022 |
Comparative efficacy and safety of glyburide, metformin, and insulin in treatment of gestational diabetes mellitus: A protocol for systematic review and meta-analysis.
Topics: Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Insulin; Meta-Analysis as Top | 2022 |
Association of Glyburide and Subcutaneous Insulin With Perinatal Complications Among Women With Gestational Diabetes.
Topics: Adult; Cohort Studies; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Infant | 2022 |
In vivo pharmacokinetic analyses of placental transfer of three drugs of different physicochemical properties in pregnant rats.
Topics: Animals; Female; Fentanyl; Fetus; Glyburide; Maternal-Fetal Exchange; Placenta; Pregnancy; Rats; Rat | 2022 |
Early Postnatal Use of Glibenclamide in Permanent Neonatal Diabetes Secondary to Antenatally Diagnosed KJCN11 Mutation.
Topics: Blood Glucose; Diabetes Mellitus; Female; Glyburide; Humans; Hypoglycemic Agents; Infant; Infant, Ne | 2022 |
Efficacy and safety of hypoglycemic agents on gestational diabetes mellitus in women: A Bayesian network analysis of randomized controlled trials.
Topics: Birth Weight; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemia; Hypoglycemic Agents; I | 2022 |
EXPERIMENTAL GESTATIONAL DIABETES DISRUPTS THE FORMATION OF IMMUNE TOLERANCE IN OFFSPRING.
Topics: Animals; CTLA-4 Antigen; Diabetes Mellitus, Experimental; Diabetes, Gestational; DNA-Binding Protein | 2023 |
Insulin Detemir Versus Glibenclamide in Gestational Diabetes Mellitus: A Retrospective Cohort Study.
Topics: Birth Weight; Diabetes, Gestational; Female; Glucose; Glyburide; Humans; Infant; Infant, Newborn; In | 2023 |
Use of Antidiabetic drugs during pregnancy among U.S. women with Livebirth deliveries in the Mini-Sentinel system.
Topics: Administrative Claims, Healthcare; Adolescent; Adult; Child; Databases, Factual; Diabetes Mellitus; | 2019 |
Comparative effects of glibenclamide, metformin and insulin on fetal pancreatic histology and maternal blood glucose in pregnant streptozotocin-induced diabetic rats.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetes, Gestational; Female; | 2019 |
Glibenclamide transfer across the perfused human placenta is determined by albumin binding not transporter activity.
Topics: Albumins; ATP Binding Cassette Transporter, Subfamily G, Member 2; Female; Glyburide; Humans; Neopla | 2020 |
Diabetes treatment in two pregnant women with permanent neonatal diabetes mellitus due to a KCNJ11 mutation.
Topics: Adult; Diabetes Mellitus; Drug Therapy, Combination; Female; Fetal Macrosomia; Glyburide; Glycemic C | 2020 |
Characterization of women with gestational diabetes who failed to achieve glycemic control by lifestyle modifications.
Topics: Adult; Blood Glucose; Body Mass Index; Diabetes, Gestational; Female; Glucose Tolerance Test; Glybur | 2021 |
Treatment of Gestational Diabetes Mellitus and Offspring Early Childhood Growth.
Topics: Adult; Birth Weight; Child Development; Child, Preschool; Cohort Studies; Diabetes, Gestational; Die | 2021 |
Comment on Nachum et al. Glyburide Versus Metformin and Their Combination for the Treatment of Gestational Diabetes Mellitus: A Randomized Controlled Study. Diabetes Care 2017;40:332-337.
Topics: Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; In | 2017 |
Response to Comment on Nachum et al. Glyburide Versus Metformin and Their Combination for the Treatment of Gestational Diabetes Mellitus: A Randomized Controlled Study. Diabetes Care 2017;40:332-337.
Topics: Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; In | 2017 |
Glyburide treatment in gestational diabetes is associated with increased placental glucose transporter 1 expression and higher birth weight.
Topics: Birth Weight; Diabetes, Gestational; Fatty Acid Transport Proteins; Female; Glucose Transporter Type | 2017 |
Decreased insulin secretion in pregnant rats fed a low protein diet.
Topics: Animals; Arginine; Blood Glucose; Diet, Protein-Restricted; Dietary Proteins; Female; Glucose; Gluco | 2017 |
Glibenclamide inhibits NLRP3 inflammasome-mediated IL-1β secretion in human trophoblasts.
Topics: Amides; Bucladesine; Caspase 1; Cell Differentiation; Cells, Cultured; Female; Glyburide; Humans; In | 2017 |
Placental Drug Transport-on-a-Chip: A Microengineered In Vitro Model of Transporter-Mediated Drug Efflux in the Human Placental Barrier.
Topics: Female; Glyburide; Humans; Lab-On-A-Chip Devices; Placenta; Pregnancy | 2018 |
Pharmacological treatment of gestational diabetes mellitus: point/counterpoint.
Topics: Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Insulin; Metformin; Pregnancy | 2018 |
Role of AKR1C3 in renal injury and glibenclamide is anti-inflammatory in preeclamptic rats.
Topics: Acute Kidney Injury; Aldo-Keto Reductase Family 1 Member C3; Animals; Anti-Inflammatory Agents; Dise | 2018 |
Insulin vs Glyburide for Gestational Diabetes.
Topics: Blood Glucose; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Insulin; Pregn | 2018 |
Needle beats pill in gestational diabetes mellitus.
Topics: Blood Glucose; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Insulin; Pregn | 2018 |
Glyburide vs Insulin for Gestational Diabetes.
Topics: Blood Glucose; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemia; Hypoglycemic Agents; | 2018 |
Glyburide vs Insulin for Gestational Diabetes-Reply.
Topics: Blood Glucose; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemia; Hypoglycemic Agents; | 2018 |
Retrospective cohort study comparing neonatal outcomes of women treated with glyburide or insulin in gestational diabetes: a 5-year experience in a South Indian teaching hospital.
Topics: Adult; Birth Weight; Blood Glucose; Diabetes, Gestational; Female; Fetal Macrosomia; Glyburide; Hosp | 2011 |
A pharmacologic approach to the use of glyburide in pregnancy.
Topics: Administration, Oral; Blood Glucose; C-Peptide; Diabetes, Gestational; Female; Glyburide; Humans; Hy | 2013 |
Expansion of a PBPK model to predict disposition in pregnant women of drugs cleared via multiple CYP enzymes, including CYP2B6, CYP2C9 and CYP2C19.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Biotransformation; Computer Simulation; Cytochrome P-450 CYP | 2014 |
Cannabidiol enhances xenobiotic permeability through the human placental barrier by direct inhibition of breast cancer resistance protein: an ex vivo study.
Topics: Analysis of Variance; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette | 2013 |
Comment on 'Glyburide as treatment option for gestational diabetes mellitus'.
Topics: Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Pregnancy | 2014 |
Trends in glyburide compared with insulin use for gestational diabetes treatment in the United States, 2000-2011.
Topics: Adolescent; Adult; Comorbidity; Diabetes, Gestational; Female; Glyburide; Humans; Hyperandrogenism; | 2014 |
Maternal-fetal disposition of glyburide in pregnant mice is dependent on gestational age.
Topics: Animals; Area Under Curve; Cytochrome P-450 CYP3A; Female; Fetus; Gestational Age; Glyburide; Hypogl | 2014 |
Trends in glyburide compared with insulin use for gestational diabetes treatment in the United States, 2000-2011.
Topics: Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Practice Patterns, Physicians | 2014 |
Quantitative determination of metformin, glyburide and its metabolites in plasma and urine of pregnant patients by LC-MS/MS.
Topics: Adult; Chromatography, High Pressure Liquid; Diabetes, Gestational; Female; Glyburide; Humans; Hypog | 2015 |
Fetal macrosomia and neonatal hyperinsulinemic hypoglycemia associated with transplacental transfer of sulfonylurea in a mother with KCNJ11-related neonatal diabetes.
Topics: Adult; Congenital Hyperinsulinism; Diabetes Mellitus; Female; Fetal Macrosomia; Glyburide; Humans; H | 2014 |
Which oral hypoglycaemic for gestational diabetes?
Topics: Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Insulin; Metformin; Pregnancy | 2015 |
Glyburide transport across the human placenta.
Topics: Adult; Diabetes, Gestational; Female; Fetal Blood; Glyburide; Humans; Hypoglycemic Agents; Maternal- | 2015 |
Glyburide for gestational diabetes: time for a pause for thought.
Topics: Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Insulin; Pregnancy; Pregnancy | 2015 |
Association of Adverse Pregnancy Outcomes With Glyburide vs Insulin in Women With Gestational Diabetes.
Topics: Adult; Cohort Studies; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Infant | 2015 |
Use of glyburide to treat gestational diabetes is linked to adverse outcomes in babies, study finds.
Topics: Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Insulin; Pregnancy; Pregnancy | 2015 |
Endoplasmic reticulum stress is increased in adipose tissue of women with gestational diabetes.
Topics: Adipose Tissue; Adult; Biomarkers; Caspase 1; Connexins; Diabetes, Gestational; Endoplasmic Reticulu | 2015 |
Diabetes: Therapy for gestational diabetes mellitus--time for a change?
Topics: Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Insulin; Metformin; Pregnancy | 2015 |
ATP-sensitive potassium channels modulate in vitro tocolytic effects of β₂-adrenergic receptor agonists on uterine muscle rings in rats in early but not in late pregnancy.
Topics: Adrenergic beta-2 Receptor Agonists; Albuterol; Animals; Drug Synergism; Female; Glyburide; In Vitro | 2015 |
Weight gain in gestational diabetes: the effect of treatment modality.
Topics: Adult; Blood Glucose; Diabetes, Gestational; Diet Therapy; Female; Glyburide; Humans; Insulin; Pregn | 2016 |
In women with gestational diabetes requiring drug treatment, glibenclamide may be inferior to insulin and metformin: metformin (plus insulin when required) performs better than insulin.
Topics: Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Insulin; Metformin; Pregnancy | 2015 |
Examining the Starting Dose of Glyburide in Gestational Diabetes.
Topics: Adult; Birth Weight; Cesarean Section; Cohort Studies; Diabetes, Gestational; Dystocia; Female; Feta | 2016 |
Glyburide vs Insulin and Adverse Pregnancy Outcomes.
Topics: Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Insulin; Practice Patterns, P | 2015 |
Glyburide vs Insulin and Adverse Pregnancy Outcomes.
Topics: Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Insulin; Pregnancy; Pregnancy | 2015 |
Glyburide vs Insulin and Adverse Pregnancy Outcomes--Reply.
Topics: Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Insulin; Pregnancy; Pregnancy | 2015 |
Predicting failure of glyburide therapy in gestational diabetes.
Topics: Adult; Blood Glucose; Cohort Studies; Diabetes, Gestational; Dose-Response Relationship, Drug; Drug | 2016 |
Genetic and Dietary Regulation of Glyburide Efflux by the Human Placental Breast Cancer Resistance Protein Transporter.
Topics: Adolescent; Adult; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Tra | 2016 |
Non-insulin pharmacological therapy in pregnancy.
Topics: Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Insulin; Metformin; Pregnancy | 2016 |
Insulin detemir versus glyburide in women with gestational diabetes mellitus.
Topics: Adult; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Insulin Detemir; Outco | 2016 |
The role of placental breast cancer resistance protein in the efflux of glyburide across the human placenta.
Topics: ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biologic | 2008 |
Investigating the potential role of multi-drug resistance protein (MRP) transporters in fetal to maternal glyburide efflux in the human placenta.
Topics: Adult; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Indomethacin; Male; Ma | 2008 |
Human endothelial cells of the placental barrier efficiently deliver cholesterol to the fetal circulation via ABCA1 and ABCG1.
Topics: Apolipoprotein A-I; ATP Binding Cassette Transporter 1; ATP Binding Cassette Transporter, Subfamily | 2009 |
Glibenclamide improves neurological function in neonatal hypoxia-ischemia in rats.
Topics: Animals; Animals, Newborn; ATP-Binding Cassette Transporters; Behavior, Animal; Blood Glucose; Brain | 2009 |
Chronic nicotine blunts hypoxic sensitivity in perinatal rat adrenal chromaffin cells via upregulation of KATP channels: role of alpha7 nicotinic acetylcholine receptor and hypoxia-inducible factor-2alpha.
Topics: Adrenal Glands; alpha7 Nicotinic Acetylcholine Receptor; Analysis of Variance; Animals; Animals, New | 2009 |
Maternal serum adiponectin multimers in gestational diabetes.
Topics: Adiponectin; Adult; Body Mass Index; Case-Control Studies; Cross-Sectional Studies; Diabetes, Gestat | 2009 |
Identification of the major human hepatic and placental enzymes responsible for the biotransformation of glyburide.
Topics: Antibodies; Cross Reactions; Cytochrome P-450 Enzyme System; Female; Glyburide; Humans; Isoenzymes; | 2009 |
Transplacental pharmacokinetics of glyburide, rhodamine 123, and BODIPY FL prazosin: effect of drug efflux transporters and lipid solubility.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, | 2009 |
[Oral blood glucose-lowering medication as a monotherapy in gestational diabetes: a hotly debated topic].
Topics: Administration, Oral; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Insulin | 2009 |
Glyburide: caution for efficacy and fetal programming effects.
Topics: Adipose Tissue; Birth Weight; Diabetes, Gestational; Female; Fetal Development; Glyburide; Humans; H | 2010 |
Impact of hyperlipidemia on plasma protein binding and hepatic drug transporter and metabolic enzyme regulation in a rat model of gestational diabetes.
Topics: Animals; Binding, Competitive; Biological Transport; Blood Proteins; Carrier Proteins; Chromatograph | 2010 |
Role of human placental apical membrane transporters in the efflux of glyburide, rosiglitazone, and metformin.
Topics: Adenosine Triphosphate; Biological Transport; Carbon Radioisotopes; Carrier Proteins; Cell Polarity; | 2010 |
Increased glyburide clearance in the pregnant mouse model.
Topics: Animals; Disease Models, Animal; Female; Glyburide; Hypoglycemic Agents; Mice; Pregnancy | 2010 |
Adrenomedullin relaxes rat uterine artery: mechanisms and influence of pregnancy and estradiol.
Topics: Adrenomedullin; Animals; Calcitonin Gene-Related Peptide; Dose-Response Relationship, Drug; Endothel | 2010 |
Contribution of potassium in human placental steroidogenesis.
Topics: Blotting, Western; Cholesterol; Female; Glyburide; Humans; Ionophores; KATP Channels; Membrane Poten | 2010 |
Clinical outcomes of pregnancies complicated by mild gestational diabetes mellitus differ by combinations of abnormal oral glucose tolerance test values.
Topics: Adult; Diabetes, Gestational; Exercise; Female; Glucose Tolerance Test; Glyburide; Humans; Hypoglyce | 2010 |
Glyburide in gestational diabetes--prediction of treatment failure.
Topics: Adult; Biomarkers, Pharmacological; Birth Weight; Diabetes, Gestational; Female; Gestational Age; Gl | 2011 |
Hypoglycemia in glyburide-treated gestational diabetes: is it dose-dependent?
Topics: Adult; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemia; Hypoglycemic Agents; Pregnanc | 2011 |
Neonatal chemical hypoglycemia in newborns from pregnancies complicated by type 2 and gestational diabetes mellitus - the importance of neonatal ponderal index.
Topics: Birth Weight; Blood Glucose; Cohort Studies; Diabetes Mellitus, Type 2; Diabetes, Gestational; Femal | 2012 |
Oral hypoglycemic agents in pregnancy.
Topics: Administration, Oral; Breast Feeding; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic | 2011 |
Treatment of gestational diabetes mellitus: glyburide compared to subcutaneous insulin therapy and associated perinatal outcomes.
Topics: Adolescent; Adult; Cohort Studies; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Ag | 2012 |
Hypoglycemia in glyburide-treated gestational diabetes: is it dose-dependent?
Topics: Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemia; Hypoglycemic Agents; Pregnancy | 2011 |
[Ontogeny of sulphonylurea-binding regulatory subunits of K(ATP) channels in the pregnant rat myometrium].
Topics: Animals; ATP-Binding Cassette Transporters; Blotting, Western; Diazoxide; Female; Gene Expression Re | 2011 |
The effect of maternal obesity on pregnancy outcomes of women with gestational diabetes controlled with diet only, glyburide, or insulin.
Topics: Comorbidity; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Insulin; Logisti | 2012 |
A new slow releasing, H₂S generating compound, GYY4137 relaxes spontaneous and oxytocin-stimulated contractions of human and rat pregnant myometrium.
Topics: Adult; Animals; Calcium Channels, L-Type; Dose-Response Relationship, Drug; Female; Glyburide; Human | 2012 |
Small-molecule inhibitors of the cystic fibrosis transmembrane conductance regulator increase pancreatic endocrine cell development in rat and mouse.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Cystic Fibrosis Transmembrane Conductance Reg | 2013 |
Evidence of K and Ca channels in endothelial cells of human allantochorial placental vessels.
Topics: Acetylcholine; Allantois; Blood Vessels; Calcium Channels; Chorion; Endothelium, Vascular; Female; G | 2002 |
Glibenclamide inhibits islet carnitine palmitoyltransferase 1 activity, leading to PKC-dependent insulin exocytosis.
Topics: Animals; Carnitine O-Palmitoyltransferase; Cell Membrane; Diglycerides; Enzyme Inhibitors; Exocytosi | 2003 |
YC-1, a nitric oxide-independent activator of soluble guanylate cyclase, inhibits the spontaneous contractions of isolated pregnant rat myometrium.
Topics: Animals; Depression, Chemical; Dose-Response Relationship, Drug; Enzyme Activators; Female; Glyburid | 2004 |
Synopsis of the North American Diabetes in Pregnancy Study Group Conference in Little Rock, Arkansas, May 2003.
Topics: Blood Glucose; Caffeine; Cesarean Section; Congenital Abnormalities; Delivery, Obstetric; Diabetes, | 2004 |
Use of glyburide for the treatment of gestational diabetes: the San Antonio experience.
Topics: Adult; Blood Glucose; Diabetes, Gestational; Dose-Response Relationship, Drug; Drug Administration S | 2004 |
Prospective observational study to establish predictors of glyburide success in women with gestational diabetes mellitus.
Topics: Adult; Blood Glucose; Diabetes, Gestational; Dose-Response Relationship, Drug; Drug Administration S | 2004 |
Glyburide for the treatment of gestational diabetes.
Topics: Adult; Blood Glucose; Cohort Studies; Confidence Intervals; Diabetes, Gestational; Diet, Diabetic; D | 2004 |
Undiagnosed asymptomatic hypoglycemia: diet, insulin, and glyburide for gestational diabetic pregnancy.
Topics: Adult; Blood Glucose; Diabetes, Gestational; Diet, Diabetic; Female; Glyburide; Humans; Hypoglycemia | 2004 |
Breakthrough in treating gestational diabetes mellitus.
Topics: Adult; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Insulin; Manitoba; Pat | 2004 |
Prostaglandin E2--mediated relaxation of the ductus arteriosus: effects of gestational age on g protein-coupled receptor expression, signaling, and vasomotor control.
Topics: 16,16-Dimethylprostaglandin E2; 8-Bromo Cyclic Adenosine Monophosphate; Adenosine; Adenylyl Cyclases | 2004 |
Insulin and glyburide therapy: dosage, severity level of gestational diabetes, and pregnancy outcome.
Topics: Administration, Oral; Blood Glucose; Diabetes, Gestational; Drug Administration Schedule; Female; Fe | 2005 |
Impaired KATP channel function in the fetoplacental circulation of patients with type 1 diabetes mellitus.
Topics: 4-Aminopyridine; Charybdotoxin; Diabetes Mellitus, Type 1; Endothelial Cells; Female; Glyburide; Hum | 2005 |
Glyburide: the new alternative for treating gestational diabetes?
Topics: Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Pregnancy | 2005 |
Comparison of glyburide and insulin for the management of gestational diabetes in a large managed care organization.
Topics: Adult; Birth Weight; Blood Glucose; Diabetes, Gestational; Fasting; Female; Glucose Tolerance Test; | 2005 |
Effects of calcium channel blocker, mibefradil, and potassium channel opener, pinacidil, on the contractile response of mid-pregnant goat myometrium.
Topics: Adenosine Triphosphate; Animals; Calcium Channel Blockers; Dose-Response Relationship, Drug; Female; | 2005 |
Perfusion studies of glyburide transfer across the human placenta: implications for fetal safety.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Female; Fetus | 2006 |
Comparison of glyburide and insulin for the management of gestational diabetes in a large managed care organization.
Topics: Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Insulin; Managed Care Program | 2006 |
Predictors of glyburide failure in the treatment of gestational diabetes.
Topics: Adult; Cesarean Section; Diabetes, Gestational; Female; Fetal Macrosomia; Glyburide; Humans; Hypogly | 2006 |
Effect of human serum albumin on transplacental transfer of glyburide.
Topics: Female; Glyburide; Humans; Hypoglycemic Agents; Maternal-Fetal Exchange; Placenta; Pregnancy | 2006 |
The effects of volatile anesthetics on spontaneous contractility of isolated human pregnant uterine muscle: a comparison among sevoflurane, desflurane, isoflurane, and halothane.
Topics: Anesthetics, Inhalation; Calcium; Desflurane; Dose-Response Relationship, Drug; Female; Glyburide; H | 2006 |
Role of ATP-sensitive potassium channels in normal and hypertension-associated pregnancy in rats.
Topics: Adenosine Triphosphate; Animals; Blood Glucose; Blood Pressure; Female; Glyburide; Hypertension, Pre | 2006 |
Role of ATP-dependent potassium channels in pulmonary vascular tone of fetal lambs with congenital diaphragmatic hernia.
Topics: Adenosine Triphosphate; Animals; Female; Glyburide; Hernia, Diaphragmatic; Hernias, Diaphragmatic, C | 2006 |
Glyburide for the management of gestational diabetes: risk factors predictive of failure and associated pregnancy outcomes.
Topics: Adult; Diabetes, Gestational; Female; Glucose Tolerance Test; Glyburide; Humans; Hypoglycemic Agents | 2006 |
Drugs in pregnancy: acknowledging challenges--finding solutions.
Topics: Abnormalities, Drug-Induced; Antidepressive Agents; Canada; Clinical Trials as Topic; Drug Industry; | 2007 |
Case 36-2006: a pregnant woman with new hypertension.
Topics: Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Diabetes, Gestational; Female; Glyburide; Humans | 2007 |
Comparison of glyburide and insulin for the management of gestational diabetics with markedly elevated oral glucose challenge test and fasting hyperglycemia.
Topics: Adult; Blood Glucose Self-Monitoring; Combined Modality Therapy; Diabetes, Gestational; Diet, Diabet | 2007 |
Gestational diabetes mellitus: what is the optimal treatment modality?
Topics: Diabetes, Gestational; Diet, Diabetic; Exercise; Female; Glyburide; Humans; Hypoglycemic Agents; Inf | 2007 |
Kinetics of glyburide metabolism by hepatic and placental microsomes of human and baboon.
Topics: Animals; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Female; Glyburide; Humans | 2007 |
Validation of a sensitive LC-MS assay for quantification of glyburide and its metabolite 4-transhydroxy glyburide in plasma and urine: an OPRU Network study.
Topics: Chromatography, High Pressure Liquid; Diabetes, Gestational; Female; Glucuronidase; Glyburide; Human | 2007 |
A simple and rapid HPLC method for the detection of glyburide in plasma original research communication (analytical).
Topics: Chemical Fractionation; Chromatography, High Pressure Liquid; Diabetes, Gestational; Drug Monitoring | 2008 |
The breast cancer resistance protein (Bcrp1/Abcg2) limits fetal distribution of glyburide in the pregnant mouse: an Obstetric-Fetal Pharmacology Research Unit Network and University of Washington Specialized Center of Research Study.
Topics: Animals; Area Under Curve; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cass | 2008 |
The effectiveness of glibenclamide in women with gestational diabetes.
Topics: Adult; Analysis of Variance; Asia; Case-Control Studies; Chi-Square Distribution; Diabetes, Gestatio | 2008 |
Glyburide is a safe and effective treatment for gestational diabetes.
Topics: Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Insulin; Pregnancy; Treatment | 2008 |
Effect of albumin on transplacental transfer and distribution of rosiglitazone and glyburide.
Topics: Female; Fetal Blood; Glyburide; Humans; Hypoglycemic Agents; In Vitro Techniques; Maternal-Fetal Exc | 2008 |
Glyburide metabolism by placentas of healthy and gestational diabetics.
Topics: Adult; Chromatography, Liquid; Diabetes, Gestational; Diet, Diabetic; Female; Glyburide; Humans; Hyp | 2008 |
Effect of endotoxin on the expression of placental drug transporters and glyburide disposition in pregnant rats.
Topics: Animals; ATP-Binding Cassette Transporters; Blotting, Western; Chromatography, High Pressure Liquid; | 2008 |
Gap junctions in several tissues share antigenic determinants with liver gap junctions.
Topics: Animals; Epitopes; Female; Fluorescent Antibody Technique; Glyburide; Histocytochemistry; Immunosorb | 1984 |
Pregnancy in established non-insulin-dependent diabetics. A five-and-a-half year study at Groote Schuur Hospital.
Topics: Diabetes Mellitus; Female; Glyburide; Humans; Infant Mortality; Insulin; Labor, Induced; Metformin; | 1980 |
Interrelationship of insulin and somatomedin activity in fetal rats.
Topics: Animals; Blood Glucose; Body Weight; Female; Fetus; Glucose; Glyburide; Insulin; Male; Maternal-Feta | 1982 |
Glyburide crosses the placenta in vivo in pregnant rats.
Topics: Animals; Carbon Radioisotopes; Diazepam; Female; Fetus; Gestational Age; Glyburide; Hypoglycemic Age | 1995 |
Insulin-dependent diabetes of pregnancy treated with the combination of sulfonylurea and insulin.
Topics: Adult; Combined Modality Therapy; Diabetes Mellitus, Type 2; Diabetes, Gestational; Drug Administrat | 1995 |
The role of endothelin and endothelin receptor subtypes in regulation of fetal pulmonary vascular tone.
Topics: Animals; Endothelin Receptor Antagonists; Endothelins; Female; Fetus; Glyburide; Peptides, Cyclic; P | 1994 |
Comparative placental transport of oral hypoglycemic agents in humans: a model of human placental drug transfer.
Topics: Administration, Oral; Analysis of Variance; Antipyrine; Biological Transport; Chlorpropamide; Chroma | 1994 |
Effects of metabolic inhibition and changes of intracellular pH on potassium permeability and contraction of rat uterus.
Topics: Adenosine Triphosphate; Animals; Antimetabolites; Cell Hypoxia; Cyanides; Female; Glyburide; Hydroge | 1993 |
Relaxation by calcitonin gene-related peptide may involve activation of K+ channels in the human uterine artery.
Topics: Adenosine Triphosphate; Adult; Arteries; Calcitonin Gene-Related Peptide; Female; Glyburide; Guanidi | 1993 |
Sulfonylurea receptor expression in rat brain: effect of chronic hypoxia during development.
Topics: Animals; Animals, Newborn; ATP-Binding Cassette Transporters; Brain; Female; Fetal Hypoxia; Glyburid | 1993 |
Inhibition of contractions of the isolated human myometrium by potassium channel openers.
Topics: Benzopyrans; Cromakalim; Female; Glyburide; Humans; Ion Channel Gating; Oxytocin; Parasympatholytics | 1993 |
Oxygen causes fetal pulmonary vasodilation through activation of a calcium-dependent potassium channel.
Topics: Alkaloids; Aminoquinolines; Animals; Carbazoles; Charybdotoxin; Endothelium, Vascular; Enzyme Inhibi | 1996 |
Ventilation-induced pulmonary vasodilation at birth is modulated by potassium channel activity.
Topics: Adenosine Triphosphate; Animals; Female; Fetus; Glyburide; Labor, Obstetric; Oxygen; Potassium Chann | 1996 |
KATP channel activation in a rabbit model of chronic myocardial hypoxia.
Topics: Action Potentials; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Animals, Newborn; Chronic | 1997 |
Activation of large-conductance potassium channels in pregnant human myometrium by pinacidil.
Topics: Calcium; Charybdotoxin; Electric Conductivity; Female; Glyburide; Guanidines; Humans; Muscle Relaxat | 1998 |
Effect of K+ATP channel inhibition on total and regional vascular resistance in guinea pig pregnancy.
Topics: Angiotensin II; Animals; Blood Pressure; Cardiac Output; Female; Glyburide; Guinea Pigs; Hemodynamic | 1998 |
Hyperpolarization and slowing of the rate of contraction in human uterus in pregnancy by prostaglandins E2 and f2alpha: involvement of the Na+ pump.
Topics: Albuterol; Calcium; Calcium Channel Blockers; Charybdotoxin; Cyclic AMP; Dinoprost; Dinoprostone; En | 1999 |
Mechanisms of adrenomedullin-induced increase of pulmonary blood flow in fetal sheep.
Topics: Adrenomedullin; Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor A | 1999 |
Post-partum prolongation of the atrial repolarization in rabbit.
Topics: 4-Aminopyridine; Action Potentials; Animals; Atrial Function; Electrophysiology; Estrogens; Female; | 1999 |
Roles of potassium channels and nitric oxide in modulation of uterine contractions in rat pregnancy.
Topics: Adenosine Triphosphate; Animals; Benzimidazoles; Cromakalim; Female; Gestational Age; Glyburide; In | 1999 |
cAMP-activated anion conductance is associated with expression of CFTR in neonatal mouse cardiac myocytes.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Adenosine Triphosphate; Animals; Animals, Newborn; | 2000 |
Effects of potassium channel modulators on myotropic responses of aortic rings of pregnant rats.
Topics: Animals; Aorta; Benzimidazoles; Cromakalim; Female; Glyburide; In Vitro Techniques; Muscle, Smooth, | 2000 |
A comparison between the pregnancy outcome of women with gestation diabetes treated with glibenclamide and those treated with insulin.
Topics: Birth Weight; Diabetes, Gestational; Female; Fetal Macrosomia; Glyburide; Humans; Hypoglycemic Agent | 1997 |
Guanylate cyclase and not ATP-dependent K(+) channels seems temperature-dependent in smooth muscle relaxation of human umbilical arteries.
Topics: Adenosine Triphosphate; Arginine; Cromakalim; Dose-Response Relationship, Drug; Female; Glyburide; G | 2000 |
Oral hypoglycemic drugs for gestational diabetes.
Topics: Blood Glucose; Congenital Abnormalities; Diabetes, Gestational; Female; Fetal Blood; Fetal Macrosomi | 2000 |
Chronic hypoxia increases the NO contribution of acetylcholine vasodilation of the fetal guinea pig heart.
Topics: 4-Aminopyridine; Acetylcholine; Animals; Coronary Vessels; Female; Fetal Hypoxia; Gene Expression Re | 2000 |
Oxygen dilation in fetal pulmonary arterioles: role of K(+) channels.
Topics: 4-Aminopyridine; Animals; Arterioles; Charybdotoxin; Female; Fetus; Glyburide; Hypoglycemic Agents; | 2001 |
The use of glyburide in gestational diabetes--an ideal example of "bench to bedside".
Topics: Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; In Vitro Techniques; Insulin; | 2001 |
A comparison of glyburide and insulin in women with gestational diabetes mellitus.
Topics: Adult; Diabetes, Gestational; Female; Glucose Intolerance; Glyburide; Humans; Hypoglycemic Agents; I | 2001 |
The role of K(+) channels on the inhibitor effect of sevoflurane in pregnant rat myometrium.
Topics: Adenosine Triphosphate; Anesthetics, Inhalation; Animals; Dose-Response Relationship, Drug; Female; | 2002 |
Beta-adrenoceptor-mediated control of apical membrane conductive properties in fetal distal lung epithelia.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Adrenergic beta-Agonists; Animals; Barium; Cell Po | 2002 |
Polyamine effects on human myometrial contractility.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2002 |
Diabetes newly diagnosed during pregnancy: A 4-year study at Groote Schuur Hospital.
Topics: Adolescent; Adult; Birth Weight; Black or African American; Black People; Delivery, Obstetric; Diabe | 1979 |
Insulin secretion in the perinatal period of the rat in vivo and in vitro effects of glucose and gibenclamide (HB 419).
Topics: Animals; Animals, Newborn; Female; Fetus; Glucose; Glyburide; In Vitro Techniques; Insulin; Insulin | 1975 |
In vivo cytogenetic activity of sulphonylurea drugs in man.
Topics: Adult; Chlorpropamide; Chromosome Aberrations; Chromosome Deletion; Diabetes Mellitus; Female; Glybu | 1976 |
[Effects of hypoglycemic agents on development of the eye of rat embryos (author's transl)].
Topics: Animals; Carbutamide; Eye; Female; Glyburide; Humans; Infant, Newborn; Pregnancy; Rats | 1976 |
Comparative effects of the K+ channel openers, pinacidil and cromakalim on vascular tone: sensitivity to glyburide and calcium.
Topics: Animals; Benzopyrans; Calcium; Cromakalim; Female; Glyburide; Guanidines; Humans; In Vitro Technique | 1992 |
K+ channel pulmonary vasodilation in fetal lambs: role of endothelium-derived nitric oxide.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Acetylcholine; Animals; Arginine; Blood Pressure; Female; Fe | 1992 |
Insignificant transfer of glyburide occurs across the human placenta.
Topics: Diazepam; Female; Glyburide; Humans; Maternal-Fetal Exchange; Models, Biological; Placenta; Pregnanc | 1991 |
Effects of several potassium channel openers and glibenclamide on the uterus of the rat.
Topics: Animals; Benzopyrans; Blood Pressure; Cromakalim; Female; Glyburide; Guanidines; Heart Rate; Hemodyn | 1990 |
[Importance of calcium in the interaction between prostaglandins E and sulfonylureas in utero].
Topics: Animals; Calcium; Dose-Response Relationship, Drug; Drug Interactions; Female; Glyburide; Muscle Rel | 1986 |
Mild familial diabetes with dominant inheritance.
Topics: Acetohexamide; Adolescent; Adult; Aged; Blood Glucose; Carbohydrates; Child; Chlorpropamide; Diabete | 1974 |
[The influece of hypoglycemia, induced by parenterally administred glibenclamide during gravidity of the rat, on the perinatal mortality of the offspring].
Topics: Animals; Animals, Newborn; Cyclohexanes; Embryo Implantation; Female; Fetal Death; Glyburide; Hypogl | 1971 |