glyburide has been researched along with Parkinson Disease in 2 studies
Glyburide: An antidiabetic sulfonylurea derivative with actions like those of chlorpropamide
glyburide : An N-sulfonylurea that is acetohexamide in which the acetyl group is replaced by a 2-(5-chloro-2-methoxybenzamido)ethyl group.
Parkinson Disease: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Brain samples from five patients with Huntington's disease were studied." | 1.29 | Sulfonylurea binding sites in normal human brain and in Parkinson's disease, progressive supranuclear palsy and Huntington's disease. ( Agid, Y; De Paermentier, F; Holemans, S; Javoy-Agid, F; Laterre, EC; Maloteaux, JM, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tai, KK | 1 |
| Truong, DD | 1 |
| Holemans, S | 1 |
| Javoy-Agid, F | 1 |
| Agid, Y | 1 |
| De Paermentier, F | 1 |
| Laterre, EC | 1 |
| Maloteaux, JM | 1 |
2 other studies available for glyburide and Parkinson Disease
| Article | Year |
|---|---|
Activation of adenosine triphosphate-sensitive potassium channels confers protection against rotenone-induced cell death: therapeutic implications for Parkinson's disease.
Topics: Adenosine Triphosphate; Animals; Cell Death; Dose-Response Relationship, Drug; Electron Transport Co | 2002 |
Sulfonylurea binding sites in normal human brain and in Parkinson's disease, progressive supranuclear palsy and Huntington's disease.
Topics: Adenosine Triphosphate; Aged; Aged, 80 and over; Animals; ATP-Binding Cassette Transporters; Brain C | 1994 |