glyburide has been researched along with Myocardial Ischemia in 194 studies
Glyburide: An antidiabetic sulfonylurea derivative with actions like those of chlorpropamide
glyburide : An N-sulfonylurea that is acetohexamide in which the acetyl group is replaced by a 2-(5-chloro-2-methoxybenzamido)ethyl group.
Myocardial Ischemia: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cyclovirobuxine D is an active compound extracted from Buxus microphylla, which has been used for treating acute myocardial ischemia in China." | 7.74 | Cyclovirobuxine D ameliorates acute myocardial ischemia by K(ATP) channel opening, nitric oxide release and anti-thrombosis. ( Chen, S; Hu, D; Liu, X; Wang, Y, 2007) |
| "Landiolol, a highly cardioselective beta1-blocker, has cardioprotective effects against ischemia-reperfusion injury, although the precise mechanism is still unclear." | 7.74 | Landiolol has cardioprotective effects against reperfusion injury in the rat heart via the PKCepsilon signaling pathway. ( Hirai, H; Minamiyama, Y; Sakaguchi, M; Sasaki, Y; Shibata, T; Suehiro, S; Takahashi, Y; Takemura, S, 2007) |
| "Hydrogen sulfide (H2S) is a gaseous mediator, produced by the metabolic pathways that regulate tissue concentrations of sulfur-containing amino acids." | 5.33 | Exogenous hydrogen sulfide (H2S) protects against regional myocardial ischemia-reperfusion injury--Evidence for a role of K ATP channels. ( Baxter, GF; Johansen, D; Ytrehus, K, 2006) |
| "Polyphenol (-)-epigallocatechin gallate (EGCG), the most abundant catechin of green tea, appears to attenuate myocardial ischemia/reperfusion injury." | 3.76 | Polyphenol (-)-epigallocatechin gallate during ischemia limits infarct size via mitochondrial K(ATP) channel activation in isolated rat hearts. ( Chun, KJ; Jang, Y; Kim, JH; Lee, D; Song, DK; Xu, Z, 2010) |
| "This study was designed to elucidate the contribution of adenosine A(2A) and A(2B) receptors to coronary reactive hyperemia and downstream K(+) channels involved." | 3.76 | Contribution of adenosine A(2A) and A(2B) receptors to ischemic coronary dilation: role of K(V) and K(ATP) channels. ( Berwick, ZC; Dick, GM; Lynch, B; Payne, GA; Sturek, M; Tune, JD, 2010) |
| "The role of K(ATP) channels in the antiarrhythmic effect of Escherichia coli endotoxin-induced nitric oxide synthase (iNOS) was examined in an anesthetised rat model of myocardial ischemia and reperfusion arrhythmia by using glibenclamide (1 mg kg(-1)), nateglinide (10 mg kg(-1)) and repaglinide (0." | 3.74 | Glibenclamide attenuates the antiarrhythmic effect of endotoxin with a mechanism not involving K(ATP) channels. ( Erkent, U; Ertunc, M; Guc, MO; Ilhan, M; Iskit, AB; Onur, R, 2007) |
| "Cyclovirobuxine D is an active compound extracted from Buxus microphylla, which has been used for treating acute myocardial ischemia in China." | 3.74 | Cyclovirobuxine D ameliorates acute myocardial ischemia by K(ATP) channel opening, nitric oxide release and anti-thrombosis. ( Chen, S; Hu, D; Liu, X; Wang, Y, 2007) |
| "Landiolol, a highly cardioselective beta1-blocker, has cardioprotective effects against ischemia-reperfusion injury, although the precise mechanism is still unclear." | 3.74 | Landiolol has cardioprotective effects against reperfusion injury in the rat heart via the PKCepsilon signaling pathway. ( Hirai, H; Minamiyama, Y; Sakaguchi, M; Sasaki, Y; Shibata, T; Suehiro, S; Takahashi, Y; Takemura, S, 2007) |
| "Right atrial sections from four patient groups-non-diabetic, insulin-dependent diabetes mellitus (IDDM), non-insulin-dependent diabetes mellitus (NIDDM) receiving glibenclamide, and NIDDM receiving metformin-were subjected to one of the following protocols: aerobic control, simulated ischemia/reoxygenation, ischemic preconditioning before ischemia, and pharmacological preconditioning with alpha 1 agonist phenylephrine, adenosine, the mito-K(ATP) channel opener diazoxide, the protein kinase C (PKC) activator phorbol-12-myristate-13-acetate (PMA), or the p38 mitogen-activated protein kinase (p38MAPK) activator anisomycin." | 3.73 | Mitochondrial dysfunction as the cause of the failure to precondition the diabetic human myocardium. ( Fowler, A; Galiñanes, M; Hassouna, A; Loubani, M; Matata, BM; Standen, NB, 2006) |
| " Myocardial ischemia after coronary angioplasty was evaluated in 20 nondiabetic and 23 diabetic patients chronically taking either glibenclamide or glimepiride." | 3.72 | Impairment of myocardial protection in type 2 diabetic patients. ( Chou, TF; Lee, TM, 2003) |
| "Stimulation of cannabinoid receptors with endogenous cannabinoid anandamide and its enzyme-resistant analogue R-(+)-methanandamide improved cardiac resistance to arrhythmias induced by coronary occlusion and reperfusion." | 3.71 | Endogenous cannabinoids improve myocardial resistance to arrhythmogenic effects of coronary occlusion and reperfusion: a possible mechanism. ( Bernatskaya, NA; Krylatov, AV; Lishmanov, Y; Makriyannis, A; Maslov, LN; Mechoulam, R; Pertwee, RG; Sal'nikova, OM; Stefano, JB; Uzhachenko, RV, 2002) |
| " In order to investigate the role of KATP channel activation and repolarization dispersion on the 'border zone' arrhythmias induced by ischaemia-reperfusion, the effects of glibenclamide and bimakalim, agents modifying action potential (AP) duration, were studied in an in vitro model of myocardial 'border zone'." | 3.70 | KATP channels and 'border zone' arrhythmias: role of the repolarization dispersion between normal and ischaemic ventricular regions. ( Criniti, A; Ducouret, P; Flais, F; Gérard, JL; Monti, F; Picard, S; Puddu, PE; Rouet, R, 1999) |
| "In the present study, interaction of the ATP-sensitive K+-channel blocker glibenclamide with enantiomers of the antihypertensive drug, cicletanine, was studied on ischaemic myocardial function, lactate-dehydrogenase (LDH) release, and early reperfusion-induced ventricular fibrillation (VF)." | 3.70 | Cardioprotective effect of enantiomers of cicletanine (BN50417, BN50418) in ischaemic/reperfused isolated working rat hearts: interaction with glibenclamide. ( Csont, T; Droy-lefaix, MT; Ferdinandy, P; Koltai, M; Szilvássy, Z, 1999) |
| "Our results shows that blockade of the KATP channel abolishes cardioprotective effects of isoflurane in myocardial ischemia-reperfusion." | 3.69 | Blockade of ATP-sensitive K+ channel abolishes the anti-ischemic effects of isoflurane in dog hearts. ( Fujita, S; Kanaya, N; Nakayama, M; Namiki, A; Tsuchida, H, 1997) |
| "We studied the effects of ATP-sensitive potassium channel (KATP) modulation on ischemic cardiac performance and reperfusion-induced ventricular fibrillation (VF), and assessed the contribution of KATP to the cardioprotective and anti-arrhythmic effect of the anti-hypertensive drug cicletanine." | 3.69 | KATP channel modulation in working rat hearts with coronary occlusion: effects of cromakalim, cicletanine, and glibenclamide. ( Droy-Lefaix, MT; Ferdinandy, P; Koltai, M; Szilvássy, Z; Tarrade, T, 1995) |
| ", cromakalim, pinacidil) are potent relaxants of smooth muscle, their utility for treating myocardial ischemia may be limited by hypotension." | 3.69 | Cardioprotective profile of the cardiac-selective ATP-sensitive potassium channel opener BMS-180448. ( Atwal, KS; D'Alonzo, AJ; Grover, GJ; McCullough, JR; Sargent, CA, 1995) |
| "We have previously reported that cromakalim and U-89232 reduce infarct size in a rabbit model of myocardial ischemia." | 3.69 | Cardioprotection with U-89232 is not reversible with glibenclamide: evidence of a novel anti-ischemic agent derived from cromakalim. ( Moore, TL; Shebuski, RJ; Toombs, CF, 1994) |
| " Hearts were subjected to 15 min of hypoxia followed by reoxygenation in the presence and in the absence of 100 microns glyburide, an ATP-sensitive potassium channel blocker." | 3.68 | Influence of ATP-sensitive potassium channel blocker on hypoxia-induced damage of isolated guinea pig heart. ( Branz, AJ; McKean, TA, 1992) |
| "Previous studies have indicated that the ATP-sensitive potassium channels blocker glibenclamide (glyburide) can abolish preconditioning in canine models of myocardial ischemia." | 3.68 | The ATP-sensitive potassium channel blocker glibenclamide (glyburide) does not abolish preconditioning in isolated ischemic rat hearts. ( Dzwonczyk, S; Grover, GJ; Sargent, CA; Sleph, PG, 1993) |
| "Nineteen consecutive patients with type 2 diabetes and coronary artery disease entered the study." | 2.70 | Effects of treatment with sulfonylurea drugs or insulin on ischemia-induced myocardial dysfunction in type 2 diabetes. ( Avogaro, A; Bagolin, E; Negut, C; Palisi, M; Scognamiglio, R; Tiengo, A; Vigili de Kreutzenberg, S, 2002) |
| "In older patients with type 2 diabetes hospitalized for IHD, prior use of gliclazide, glyburide, or repaglinide appears to be associated with a similar risk of adverse cardiovascular sequelae." | 1.42 | Comparative cardiovascular safety of insulin secretagogues following hospitalization for ischemic heart disease among type 2 diabetes patients: a cohort study. ( Abdelmoneim, AS; Huang, Y; Light, P; Qiu, W; Simpson, SH, 2015) |
| "Cardiac dysfunction during hemorrhagic shock (HS) is associated with myocardial ischemia, during which adenosine triphosphate (ATP)-sensitive potassium (K(ATP)) channels can be activated." | 1.35 | Adenosine triphosphate-sensitive potassium channels prevent extension of myocardial ischemia to subepicardium during hemorrhagic shock. ( Adachi, T; Aikawa, N; Hori, S; Inoue, S; Miyazaki, K; Mori, H; Nakagawa, M; Nakazawa, H; Ogawa, S; Suzuki, M, 2008) |
| "Hydrogen sulfide (H2S) is a gaseous mediator, produced by the metabolic pathways that regulate tissue concentrations of sulfur-containing amino acids." | 1.33 | Exogenous hydrogen sulfide (H2S) protects against regional myocardial ischemia-reperfusion injury--Evidence for a role of K ATP channels. ( Baxter, GF; Johansen, D; Ytrehus, K, 2006) |
| "More importantly, the incidence of ventricular tachycardia in the STZ-GLIB group was significantly higher than that in the STZ-VEH group (93% vs 54%, P < 0." | 1.32 | Long-term treatment with glibenclamide increases susceptibility of streptozotocin-induced diabetic rat heart to reperfusion-induced ventricular tachycardia. ( Iwao, T; Ooie, T; Saikawa, T; Sakata, T; Takahashi, N; Yoshimatsu, H, 2003) |
| "The severity of arrhythmias (arrhythmia score, AS) was also markedly attenuated by both interventions (IPC: AS 1." | 1.31 | Preconditioning modulates susceptibility to ischemia-induced arrhythmias in the rat heart: the role of alpha-adrenergic stimulation and K(ATP) channels. ( Pancza, D; Ravingerová, T; Styk, J; Ziegelhoffer, A, 2002) |
| "Ventricular fibrillation was observed in 7/14 (control), 0/7 (glibenclamide), and 0/7 (HMR1883)." | 1.31 | Effects of the I(K.ATP) blockers glibenclamide and HMR1883 on cardiac electrophysiology during ischemia and reperfusion. ( Dhein, S; Krüsemann, K; Pejman, P, 2000) |
| "Glimepiride (Glim) is a new sulfonylurea reported to affect nonpancreatic K(ATP) channels less than does Glib." | 1.31 | Glimepiride, a novel sulfonylurea, does not abolish myocardial protection afforded by either ischemic preconditioning or diazoxide. ( Baxter, GF; Lawrence, CL; Maddock, HL; Mocanu, MM; Standen, NB; Yellon, DM, 2001) |
| "Treatment with HMR 1098 (10 mg/kg i." | 1.31 | Effects of the cardioselective KATP channel blocker HMR 1098 on cardiac function in isolated perfused working rat hearts and in anesthetized rats during ischemia and reperfusion. ( Albus, U; Busch, AE; Englert, HC; Gögelein, H; Ruetten, H, 2001) |
| "Nicorandil (SG75) is a potent K+-channel activator with an additional nitro moiety." | 1.31 | Mechanisms of the effects of nicorandil in the isolated rat heart during ischemia and reperfusion: a 31P-nuclear magnetic resonance study. ( Ertl, G; Horn, M; Hügel, S; Neubauer, S; Schnackerz, KD; Schroeder, M, 2001) |
| "Pre-treatment with cromakalim delayed the time to ischemic contracture (19." | 1.30 | Effects of cromakalim and glibenclamide on myocardial high energy phosphates and intracellular pH during ischemia-reperfusion: 31P NMR studies. ( Deslauriers, R; Docherty, JC; Gunter, HE; Kuzio, B; Shoemaker, L; Yang, L, 1997) |
| "Reactive hyperemia was induced following 30 sec and 300 sec of no-flow ischemia of the heart." | 1.30 | Types of potassium channels involved in coronary reactive hyperemia depend on duration of preceding ischemia in rat hearts. ( Ito, T; Mokuno, S; Murase, K; Okumura, K; Shinoda, M; Toki, Y, 1997) |
| "Glibenclamide increased the number of arrhythmias in the normoxic hearts from 1316+/-215 to 2091+/-187 (by 59%) and in the hypoxic group from 636+/-103 to 1777+/-186 (by 179%)." | 1.30 | Adaptation to high altitude hypoxia protects the rat heart against ischemia-induced arrhythmias. Involvement of mitochondrial K(ATP) channel. ( Asemu, G; Kolár, F; Ostádal, B; Papousek, F, 1999) |
| "Pretreatment with diazoxide (10 mg." | 1.29 | Effects of diazoxide on norepinephrine-induced vasocontraction and ischemic myocardium in rats. ( Ichihara, K; Nakai, T, 1994) |
| "Isoflurane was discontinued at the onset of the final reperfusion period." | 1.29 | Mechanism of myocardial protection by isoflurane. Role of adenosine triphosphate-regulated potassium (KATP) channels. ( Gross, GJ; Hettrick, DA; Kersten, JR; Pagel, PS; Schmeling, TJ; Warltier, DC, 1996) |
| "Glimepiride is a new sulfonylurea." | 1.29 | Cardiovascular effects of conventional sulfonylureas and glimepiride. ( Geisen, K; Krause, E; Papp, JG; Végh, A, 1996) |
| "Cromakalim is a member of the new antihypertensive drug family possessing an action that involves an increased K efflux in vascular and cardiac muscle." | 1.29 | Potassium channel openers and blockers: do they possess proarrhythmic or antiarrhythmic activity in ischemic and reperfused rat hearts? ( Das, DK; Engelman, RM; Szerdahelyi, P; Tosaki, A, 1993) |
| "Adenosine has been proposed to be an important mediator of ischemic preconditioning." | 1.29 | A comparison of adenosine-induced cardioprotection and ischemic preconditioning in dogs. Efficacy, time course, and role of KATP channels. ( Gross, GJ; Yao, Z, 1994) |
| "Because of the occurrence of arrhythmias, cardiac function was not evaluated during reperfusion." | 1.28 | Effects of glibenclamide on ventricular arrhythmias and cardiac function in ischaemia and reperfusion in isolated rat heart. ( Bril, A; Gout, B; Laville, MP, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 122 (62.89) | 18.2507 |
| 2000's | 62 (31.96) | 29.6817 |
| 2010's | 9 (4.64) | 24.3611 |
| 2020's | 1 (0.52) | 2.80 |
| Authors | Studies |
|---|---|
| Coghlan, MJ | 1 |
| Carroll, WA | 1 |
| Gopalakrishnan, M | 1 |
| Granado, M | 1 |
| González-Hedström, D | 1 |
| Amor, S | 1 |
| Fajardo-Vidal, A | 1 |
| Villalva, M | 1 |
| de la Fuente-Fernández, M | 1 |
| Tejera-Muñoz, A | 1 |
| Jaime, L | 1 |
| Santoyo, S | 1 |
| García-Villalón, AL | 1 |
| Yamazaki, M | 1 |
| Avula, UM | 1 |
| Bandaru, K | 1 |
| Atreya, A | 1 |
| Boppana, VS | 1 |
| Honjo, H | 1 |
| Kodama, I | 1 |
| Kamiya, K | 1 |
| Kalifa, J | 1 |
| Dudek, M | 1 |
| Knutelska, J | 1 |
| Bednarski, M | 1 |
| Nowiński, L | 1 |
| Zygmunt, M | 1 |
| Bilska-Wilkosz, A | 1 |
| Iciek, M | 1 |
| Otto, M | 1 |
| Żytka, I | 1 |
| Sapa, J | 1 |
| Włodek, L | 1 |
| Filipek, B | 1 |
| Huang, Y | 1 |
| Abdelmoneim, AS | 1 |
| Light, P | 1 |
| Qiu, W | 1 |
| Simpson, SH | 1 |
| Jameel, MN | 1 |
| Xiong, Q | 1 |
| Mansoor, A | 1 |
| Bache, RJ | 1 |
| Zhang, J | 1 |
| Giblett, JP | 1 |
| Axell, RG | 1 |
| White, PA | 1 |
| Clarke, SJ | 1 |
| McCormick, L | 1 |
| Read, PA | 1 |
| Reinhold, J | 1 |
| Brown, AJ | 1 |
| O'Sullivan, M | 1 |
| West, NE | 1 |
| Dutka, DP | 1 |
| Hoole, SP | 1 |
| Xu, Y | 1 |
| Liu, B | 1 |
| Zweier, JL | 1 |
| He, G | 1 |
| Ye, Y | 1 |
| Lin, Y | 1 |
| Perez-Polo, JR | 1 |
| Birnbaum, Y | 1 |
| Song, DK | 1 |
| Jang, Y | 1 |
| Kim, JH | 1 |
| Chun, KJ | 1 |
| Lee, D | 1 |
| Xu, Z | 1 |
| Berwick, ZC | 1 |
| Payne, GA | 1 |
| Lynch, B | 1 |
| Dick, GM | 1 |
| Sturek, M | 1 |
| Tune, JD | 1 |
| Farid, TA | 1 |
| Nair, K | 1 |
| Massé, S | 1 |
| Azam, MA | 1 |
| Maguy, A | 1 |
| Lai, PF | 1 |
| Umapathy, K | 1 |
| Dorian, P | 1 |
| Chauhan, V | 1 |
| Varró, A | 1 |
| Al-Hesayen, A | 1 |
| Waxman, M | 1 |
| Nattel, S | 1 |
| Nanthakumar, K | 1 |
| Smith, RM | 1 |
| Velamakanni, SS | 1 |
| Tolkacheva, EG | 1 |
| Ravingerová, T | 1 |
| Pancza, D | 1 |
| Ziegelhoffer, A | 1 |
| Styk, J | 1 |
| Saltman, AE | 1 |
| Aksehirli, TO | 1 |
| Valiunas, V | 1 |
| Gaudette, GR | 1 |
| Matsuyama, N | 1 |
| Brink, P | 1 |
| Krukenkamp, IB | 1 |
| Kupriyanov, VV | 1 |
| Xiang, B | 1 |
| Sun, J | 1 |
| Jilkina, O | 1 |
| Kosugi, T | 1 |
| Satoh, K | 2 |
| Kaneta, S | 1 |
| Aoki, Y | 1 |
| Takagaki, H | 1 |
| Ichihara, K | 5 |
| Legtenberg, RJ | 3 |
| Rongen, GA | 1 |
| Houston, RJ | 3 |
| Oeseburg, B | 3 |
| Smits, P | 4 |
| Krylatov, AV | 1 |
| Uzhachenko, RV | 1 |
| Maslov, LN | 1 |
| Bernatskaya, NA | 1 |
| Makriyannis, A | 1 |
| Mechoulam, R | 1 |
| Pertwee, RG | 1 |
| Sal'nikova, OM | 1 |
| Stefano, JB | 1 |
| Lishmanov, Y | 1 |
| Lee, TM | 3 |
| Chou, TF | 2 |
| Tsai, CH | 2 |
| Nayeem, MA | 3 |
| Matherne, GP | 1 |
| Mustafa, SJ | 1 |
| Zhu, HF | 1 |
| Dong, JW | 1 |
| Zhu, WZ | 1 |
| Ding, HL | 1 |
| Zhou, ZN | 1 |
| Riveline, JP | 1 |
| Danchin, N | 1 |
| Ledru, F | 1 |
| Varroud-Vial, M | 1 |
| Charpentier, G | 1 |
| Oldenburg, O | 1 |
| Yang, XM | 1 |
| Krieg, T | 2 |
| Garlid, KD | 2 |
| Cohen, MV | 2 |
| Grover, GJ | 15 |
| Downey, JM | 5 |
| Takahashi, N | 1 |
| Ooie, T | 1 |
| Saikawa, T | 2 |
| Iwao, T | 1 |
| Yoshimatsu, H | 1 |
| Sakata, T | 2 |
| Lindhardt, TB | 1 |
| Gadsbøll, N | 1 |
| Kelbaek, H | 1 |
| Saunamäki, K | 1 |
| Madsen, JK | 1 |
| Clemmensen, P | 1 |
| Hesse, B | 1 |
| Haunsø, S | 1 |
| LaDisa, JF | 1 |
| Krolikowski, JG | 1 |
| Pagel, PS | 3 |
| Warltier, DC | 4 |
| Kersten, JR | 3 |
| Beresewicz, A | 1 |
| Maczewski, M | 1 |
| Duda, M | 1 |
| Gori, T | 1 |
| Sicuro, S | 1 |
| Dragoni, S | 1 |
| Donati, G | 1 |
| Forconi, S | 1 |
| Parker, JD | 1 |
| Kristiansen, SB | 1 |
| Nielsen-Kudsk, JE | 1 |
| Bøtker, HE | 1 |
| Nielsen, TT | 1 |
| Shinmura, K | 1 |
| Tamaki, K | 1 |
| Bolli, R | 1 |
| Lin, MS | 1 |
| Chang, NC | 1 |
| Johansen, D | 1 |
| Ytrehus, K | 1 |
| Baxter, GF | 3 |
| Hassouna, A | 1 |
| Loubani, M | 1 |
| Matata, BM | 1 |
| Fowler, A | 1 |
| Standen, NB | 3 |
| Galiñanes, M | 3 |
| Seubert, JM | 1 |
| Sinal, CJ | 1 |
| Graves, J | 1 |
| DeGraff, LM | 1 |
| Bradbury, JA | 1 |
| Lee, CR | 1 |
| Goralski, K | 1 |
| Carey, MA | 1 |
| Luria, A | 1 |
| Newman, JW | 1 |
| Hammock, BD | 1 |
| Falck, JR | 1 |
| Roberts, H | 1 |
| Rockman, HA | 1 |
| Murphy, E | 2 |
| Zeldin, DC | 1 |
| Brennan, JP | 1 |
| Southworth, R | 1 |
| Medina, RA | 1 |
| Davidson, SM | 1 |
| Duchen, MR | 1 |
| Shattock, MJ | 2 |
| Iskit, AB | 1 |
| Erkent, U | 1 |
| Ertunc, M | 1 |
| Guc, MO | 1 |
| Ilhan, M | 1 |
| Onur, R | 1 |
| Hu, D | 1 |
| Liu, X | 1 |
| Wang, Y | 2 |
| Chen, S | 1 |
| Takahashi, Y | 1 |
| Takemura, S | 1 |
| Minamiyama, Y | 1 |
| Shibata, T | 2 |
| Hirai, H | 1 |
| Sasaki, Y | 1 |
| Sakaguchi, M | 1 |
| Suehiro, S | 1 |
| Birkenmeier, K | 1 |
| Staudt, A | 1 |
| Schunck, WH | 1 |
| Janke, I | 1 |
| Labitzke, C | 1 |
| Prange, T | 1 |
| Trimpert, C | 1 |
| Landsberger, M | 1 |
| Stangl, V | 1 |
| Felix, SB | 1 |
| Nakagawa, M | 1 |
| Hori, S | 1 |
| Adachi, T | 1 |
| Miyazaki, K | 1 |
| Inoue, S | 1 |
| Suzuki, M | 1 |
| Mori, H | 2 |
| Nakazawa, H | 1 |
| Aikawa, N | 1 |
| Ogawa, S | 3 |
| Rees, SA | 1 |
| Curtis, MJ | 1 |
| Nakae, I | 1 |
| Quan, L | 1 |
| Sugimoto, Y | 1 |
| Tsutamoto, T | 1 |
| Kinoshita, M | 1 |
| Vesper, A | 1 |
| Schrör, K | 1 |
| Shigematsu, S | 1 |
| Sato, T | 1 |
| Abe, T | 1 |
| Arita, M | 1 |
| Schulz, R | 3 |
| Rose, J | 2 |
| Post, H | 2 |
| Heusch, G | 3 |
| Billman, GE | 2 |
| Avendano, CE | 1 |
| Halliwill, JR | 1 |
| Burroughs, JM | 1 |
| McCullough, JR | 1 |
| D'Alonzo, AJ | 5 |
| Sargent, CA | 4 |
| Atwal, KS | 4 |
| Ferdinandy, P | 4 |
| Szilvássy, Z | 4 |
| Koltai, M | 3 |
| Dux, L | 2 |
| Sakka, S | 1 |
| Wallbridge, DR | 1 |
| Jerome, SN | 1 |
| Akimitsu, T | 1 |
| Gute, DC | 1 |
| Korthuis, RJ | 1 |
| Moritani, K | 2 |
| Miyazaki, T | 2 |
| Miyoshi, S | 2 |
| Asanagi, M | 2 |
| Zhao, LS | 1 |
| Mitamura, H | 1 |
| Nakai, T | 2 |
| Darbenzio, RB | 4 |
| Hess, TA | 2 |
| Sewter, JC | 1 |
| Sleph, PG | 8 |
| Walsh, RS | 1 |
| Tsuchida, A | 1 |
| Daly, JJ | 1 |
| Thornton, JD | 2 |
| Kamigaki, M | 2 |
| Abiko, Y | 2 |
| Toombs, CF | 3 |
| Moore, TL | 2 |
| Shebuski, RJ | 2 |
| Fleet, WF | 1 |
| Johnson, TA | 1 |
| Cascio, WE | 1 |
| Shen, J | 1 |
| Engle, CL | 1 |
| Martin, DG | 1 |
| Gettes, LS | 1 |
| Tomai, F | 1 |
| Crea, F | 1 |
| Gaspardone, A | 1 |
| Versaci, F | 1 |
| De Paulis, R | 1 |
| Penta de Peppo, A | 1 |
| Chiariello, L | 1 |
| Gioffrè, PA | 1 |
| Bellemin-Baurreau, J | 1 |
| Poizot, A | 1 |
| Hicks, PE | 1 |
| Rochette, L | 1 |
| Armstrong, JM | 1 |
| Siegl, P | 1 |
| Yao, Z | 3 |
| Gross, GJ | 13 |
| Iwamoto, T | 1 |
| Miura, T | 2 |
| Urabe, K | 1 |
| Itoya, M | 1 |
| Shimamoto, K | 1 |
| Iimura, O | 1 |
| McPherson, CD | 1 |
| Pierce, GN | 1 |
| Cole, WC | 1 |
| MacKenzie, I | 3 |
| Saville, VL | 1 |
| Waterfall, JF | 1 |
| Tweedie, D | 1 |
| Henderson, C | 1 |
| Kane, K | 1 |
| Opie, LH | 3 |
| Tosaki, A | 4 |
| Szerdahelyi, P | 1 |
| Engelman, RM | 3 |
| Das, DK | 3 |
| Lu, H | 1 |
| Remeysen, P | 1 |
| De Clerck, F | 1 |
| Gwilt, M | 2 |
| Norton, B | 1 |
| Henderson, CG | 2 |
| McGee, DS | 1 |
| Johnston, WE | 1 |
| Vinten-Johansen, J | 2 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Investigation Into Cardioprotective Effect of Glucagon-like Peptide-1 and it's Mechanism of Action During Myocardial Ischaemia[NCT02128022] | Phase 1 | 32 participants (Actual) | Interventional | 2014-07-31 | Completed | ||
| Effects on Bleeding in Knee Arthroplasty After Ischemic Preconditioning With Sevoflurane[NCT03379103] | 30 participants (Actual) | Interventional | 2018-02-02 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for glyburide and Myocardial Ischemia
| Article | Year |
|---|---|
Recent developments in the biology and medicinal chemistry of potassium channel modulators: update from a decade of progress.
Topics: Adenosine Triphosphate; Angina Pectoris; Arrhythmias, Cardiac; Asthma; Calcium; Ion Channel Gating; | 2001 |
Sulfonylureas and cardiovascular effects: from experimental data to clinical use. Available data in humans and clinical applications.
Topics: Animals; Arrhythmias, Cardiac; Cardiovascular Physiological Phenomena; Coronary Circulation; Glyburi | 2003 |
Modulation of ischemia by regulation of the ATP-sensitive potassium channel.
Topics: Adenosine Triphosphate; Animals; Glyburide; Myocardial Ischemia; Potassium Channels | 1993 |
[Potential role of ATP-sensitive K+ channels in ischemia- and reperfusion-induced arrhythmias].
Topics: Action Potentials; Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Benzopyrans; Cromakalim; G | 1993 |
11 trials available for glyburide and Myocardial Ischemia
| Article | Year |
|---|---|
Glucagon-like peptide-1 derived cardioprotection does not utilize a KATP-channel dependent pathway: mechanistic insights from human supply and demand ischemia studies.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Coronary Artery Disease; Coronary Vessels; Echocardiogra | 2016 |
Differential role of K(ATP) channels activated by conjugated estrogens in the regulation of myocardial and coronary protective effects.
Topics: Adenosine Triphosphate; Angioplasty, Balloon, Coronary; Cardiotonic Agents; Chest Pain; Coronary Dis | 2003 |
Pharmacological modulation of the ATP sensitive potassium channels during repeated coronary occlusions: no effect on myocardial ischaemia or function.
Topics: Adenosine Triphosphate; Angina Pectoris; Anti-Arrhythmia Agents; Balloon Occlusion; Coronary Stenosi | 2004 |
Sildenafil prevents endothelial dysfunction induced by ischemia and reperfusion via opening of adenosine triphosphate-sensitive potassium channels: a human in vivo study.
Topics: Adult; Cross-Over Studies; Double-Blind Method; Endothelium, Vascular; Glyburide; Humans; Male; Midd | 2005 |
Effect of ischaemic preconditioning on regional release of inflammatory markers.
Topics: Adult; Angioplasty, Balloon, Coronary; Biomarkers; Blood Glucose; CD40 Ligand; Electrocardiography; | 2005 |
Ischemic preconditioning during coronary angioplasty is prevented by glibenclamide, a selective ATP-sensitive K+ channel blocker.
Topics: Adenosine Triphosphate; Angioplasty, Balloon, Coronary; Blood Glucose; Calcium Channel Blockers; Cal | 1994 |
Blockade of K(ATP) channels with glibenclamide does not abolish preconditioning during demand ischemia.
Topics: Adaptation, Physiological; Adenosine Triphosphate; Aged; Cardiac Pacing, Artificial; Double-Blind Me | 1997 |
Observations on the effect of glibenclamide on noninvasive clinical parameters of myocardial ischemia.
Topics: Blood Pressure; Coronary Disease; Diabetes Mellitus, Type 2; Glyburide; Humans; Insulin; Myocardial | 1998 |
[Free radical scavenging activity of sulfonylureas: a clinical assessment of the effectiveness of gliclazide].
Topics: Adult; Aged; Blood Glucose; Diabetes Mellitus, Type 2; Follow-Up Studies; Free Radical Scavengers; G | 2001 |
Effects of treatment with sulfonylurea drugs or insulin on ischemia-induced myocardial dysfunction in type 2 diabetes.
Topics: Cardiomyopathies; Cross-Over Studies; Diabetes Mellitus, Type 2; Dipyridamole; Echocardiography, Str | 2002 |
Microcirculatory effects of KATP channel blockade by sulphonylurea derivatives in humans.
Topics: Adenosine Triphosphate; Blood Flow Velocity; Blood Pressure; Diabetes Mellitus, Type 2; Female; Glyb | 2002 |
179 other studies available for glyburide and Myocardial Ischemia
| Article | Year |
|---|---|
Marjoram extract prevents ischemia reperfusion-induced myocardial damage and exerts anti-contractile effects in aorta segments of male wistar rats.
Topics: Animals; Aorta; Calcium Channel Agonists; Calcium Channels; Endothelin-1; Glyburide; Male; Myocardia | 2022 |
Acute regional left atrial ischemia causes acceleration of atrial drivers during atrial fibrillation.
Topics: Animals; Atrial Fibrillation; Disease Models, Animal; Electrophysiologic Techniques, Cardiac; Glybur | 2013 |
Alpha lipoic acid protects the heart against myocardial post ischemia-reperfusion arrhythmias via KATP channel activation in isolated rat hearts.
Topics: Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Animals; Antioxidants; Arrhythmias, C | 2014 |
Comparative cardiovascular safety of insulin secretagogues following hospitalization for ischemic heart disease among type 2 diabetes patients: a cohort study.
Topics: Aged; Aged, 80 and over; Alberta; Blue Cross Blue Shield Insurance Plans; Carbamates; Cardiovascular | 2015 |
ATP sensitive K(+) channels are critical for maintaining myocardial perfusion and high energy phosphates in the failing heart.
Topics: Adenosine Triphosphate; Animals; Coronary Circulation; Disease Models, Animal; Dogs; Glyburide; Hear | 2016 |
Formation of hydrogen peroxide and reduction of peroxynitrite via dismutation of superoxide at reperfusion enhances myocardial blood flow and oxygen consumption in postischemic mouse heart.
Topics: Animals; Coronary Circulation; Electron Spin Resonance Spectroscopy; Glyburide; Hemodynamics; Hydrog | 2008 |
Oral glyburide, but not glimepiride, blocks the infarct-size limiting effects of pioglitazone.
Topics: Administration, Oral; Animals; Body Weight; Coronary Vessels; Data Interpretation, Statistical; Deca | 2008 |
Polyphenol (-)-epigallocatechin gallate during ischemia limits infarct size via mitochondrial K(ATP) channel activation in isolated rat hearts.
Topics: Animals; Anti-Arrhythmia Agents; Antioxidants; Catechin; Decanoic Acids; Glyburide; Heart; Hemodynam | 2010 |
Contribution of adenosine A(2A) and A(2B) receptors to ischemic coronary dilation: role of K(V) and K(ATP) channels.
Topics: 4-Aminopyridine; Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Anima | 2010 |
Role of KATP channels in the maintenance of ventricular fibrillation in cardiomyopathic human hearts.
Topics: Action Potentials; Animals; Cardiomyopathy, Dilated; Endocardium; Glyburide; Humans; In Vitro Techni | 2011 |
Interventricular heterogeneity as a substrate for arrhythmogenesis of decoupled mitochondria during ischemia in the whole heart.
Topics: Action Potentials; Animals; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Glyburide; Heterocyc | 2012 |
Preconditioning modulates susceptibility to ischemia-induced arrhythmias in the rat heart: the role of alpha-adrenergic stimulation and K(ATP) channels.
Topics: Adenosine Triphosphate; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Ant | 2002 |
Gap junction uncoupling protects the heart against ischemia.
Topics: Action Potentials; Analysis of Variance; Animals; Anti-Arrhythmia Agents; Coronary Circulation; Diac | 2002 |
The effects of drugs modulating K(+) transport on Rb(+) uptake and distribution in pig hearts following regional ischemia: (87)Rb MRI study.
Topics: Animals; Bumetanide; Glyburide; In Vitro Techniques; Magnetic Resonance Imaging; Myocardial Infarcti | 2002 |
Effects of radical scavengers, TA248 and TA276, on stunned myocardium in dogs: involvement of K ATP channels.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Dimethyl Sulfoxide; Dogs; Female; Free Radical Scaveng | 2002 |
The role of myocardial KATP-channel blockade in the protective effects of glibenclamide against ischaemia in the rat heart.
Topics: Animals; Coronary Circulation; Diazoxide; Drug Interactions; Glyburide; Male; Myocardial Ischemia; P | 2002 |
Endogenous cannabinoids improve myocardial resistance to arrhythmogenic effects of coronary occlusion and reperfusion: a possible mechanism.
Topics: Animals; Anti-Arrhythmia Agents; Arachidonic Acids; Arrhythmias, Cardiac; Calcium Channel Blockers; | 2002 |
Impairment of myocardial protection in type 2 diabetic patients.
Topics: Aged; Angioplasty, Balloon, Coronary; Blood Pressure; Chest Pain; Diabetes Mellitus, Type 2; Electro | 2003 |
Ischemic and pharmacological preconditioning induces further delayed protection in transgenic mouse cardiac myocytes over-expressing adenosine A1 receptors (A1AR): role of A1AR, iNOS and K(ATP) channels.
Topics: Adenosine Triphosphate; Animals; Cell Survival; Cells, Cultured; Enzyme Inhibitors; Gene Expression; | 2003 |
ATP-dependent potassium channels involved in the cardiac protection induced by intermittent hypoxia against ischemia/reperfusion injury.
Topics: Animals; Calcium; Decanoic Acids; Glyburide; Heart Ventricles; Hemodynamics; Hydroxy Acids; Hypoxia; | 2003 |
P1075 opens mitochondrial K(ATP) channels and generates reactive oxygen species resulting in cardioprotection of rabbit hearts.
Topics: Animals; Brain Chemistry; Decanoic Acids; Diazoxide; Glyburide; Guanidines; Hydroxy Acids; Ischemic | 2003 |
Pinacidil-induced opening, like glibenclamide-induced closure of cardiac KATP channels, protects cardiac function against ischemia in isolated, working, erythrocyte perfused rat hearts.
Topics: Animals; Glyburide; Heart; In Vitro Techniques; Ion Channel Gating; Male; Myocardial Ischemia; Pinac | 2003 |
Long-term treatment with glibenclamide increases susceptibility of streptozotocin-induced diabetic rat heart to reperfusion-induced ventricular tachycardia.
Topics: Animals; Arrhythmias, Cardiac; Blood Glucose; Blood Pressure; Body Weight; Creatine Kinase; Diabetes | 2003 |
Sublethal simulated ischemia promotes delayed resistance against ischemia via ATP-sensitive (K+) channels in murine myocytes: role of PKC and iNOS.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Cells, Cultured; Decanoic Acids; Enzyme Act | 2004 |
Cardioprotection by glucose-insulin-potassium: dependence on KATP channel opening and blood glucose concentration before ischemia.
Topics: Adenosine Triphosphate; Animals; Blood Glucose; Cardiotonic Agents; Diabetes Mellitus, Experimental; | 2004 |
Effect of classic preconditioning and diazoxide on endothelial function and O2- and NO generation in the post-ischemic guinea-pig heart.
Topics: Animals; Benzamides; Decanoic Acids; Diazoxide; Dose-Response Relationship, Drug; Endothelium, Vascu | 2004 |
Effects of KATP channel modulation on myocardial glycogen content, lactate, and amino acids in nonischemic and ischemic rat hearts.
Topics: Alanine; Amino Acids; Animals; Diazoxide; Drug Interactions; Glutamic Acid; Glyburide; Glycogen; Lac | 2005 |
Short-term caloric restriction improves ischemic tolerance independent of opening of ATP-sensitive K+ channels in both young and aged hearts.
Topics: Adenosine Triphosphate; Aging; AMP-Activated Protein Kinases; Animals; Body Weight; Caloric Restrict | 2005 |
Exogenous hydrogen sulfide (H2S) protects against regional myocardial ischemia-reperfusion injury--Evidence for a role of K ATP channels.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Cardiac Output; Decanoic Acids; Glyburide; | 2006 |
Mitochondrial dysfunction as the cause of the failure to precondition the diabetic human myocardium.
Topics: Adenosine; Adrenergic alpha-Agonists; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes Mellitu | 2006 |
Role of soluble epoxide hydrolase in postischemic recovery of heart contractile function.
Topics: Animals; Echocardiography, Transesophageal; Epoxide Hydrolases; Glyburide; Heart; Mice; Mice, Inbred | 2006 |
Mitochondrial uncoupling, with low concentration FCCP, induces ROS-dependent cardioprotection independent of KATP channel activation.
Topics: Acetylcysteine; Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Carbonyl Cyanide p-Trifluor | 2006 |
Glibenclamide attenuates the antiarrhythmic effect of endotoxin with a mechanism not involving K(ATP) channels.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Blood Pressure; Carbamates | 2007 |
Cyclovirobuxine D ameliorates acute myocardial ischemia by K(ATP) channel opening, nitric oxide release and anti-thrombosis.
Topics: Acute Disease; Animals; Animals, Newborn; Celecoxib; Cell Hypoxia; Cell Survival; Cells, Cultured; C | 2007 |
Landiolol has cardioprotective effects against reperfusion injury in the rat heart via the PKCepsilon signaling pathway.
Topics: Adrenergic beta-Antagonists; Alkaloids; Animals; Benzophenanthridines; Cardiotonic Agents; Glyburide | 2007 |
COX-2-dependent and potentially cardioprotective effects of negative inotropic substances released after ischemia.
Topics: Adenosine Triphosphate; Animals; Calcium Signaling; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenas | 2007 |
Adenosine triphosphate-sensitive potassium channels prevent extension of myocardial ischemia to subepicardium during hemorrhagic shock.
Topics: Animals; Coronary Circulation; Disease Models, Animal; Dogs; Glyburide; KATP Channels; Myocardial Is | 2008 |
Pharmacological analysis in rat of the role of the ATP-sensitive potassium channel as a potential target for antifibrillatory intervention in acute myocardial ischaemia.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Coronary Circulation; Electrocardiography; | 1995 |
Glibenclamide-induced oscillation of canine coronary artery is independent of myocardial ischemia.
Topics: Adenosine Triphosphate; Animals; Arginine; Benzopyrans; Coronary Circulation; Coronary Vessels; Crom | 1994 |
The cardioprotective actions of iloprost in myocardial ischemia of the rabbit can be separated from its vasodilatory effects mediated by KATP(+)-channel opening.
Topics: Adenosine Triphosphate; Animals; Glyburide; Heart; Iloprost; Myocardial Ischemia; Perfusion; Potassi | 1995 |
Pharmacological evidence for the persistent activation of ATP-sensitive K+ channels in early phase of reperfusion and its protective role against myocardial stunning.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Benzopyrans; Cromakalim; G | 1995 |
Regional short-term myocardial hibernation in swine does not involve endogenous adenosine or KATP channels.
Topics: Adenosine; Adenosine Deaminase; Adenosine Triphosphate; Animals; Blood Pressure; Coronary Vessels; F | 1995 |
The effects of the ATP-dependent potassium channel antagonist, glyburide, on coronary blood flow and susceptibility to ventricular fibrillation in unanesthetized dogs.
Topics: Adenosine Triphosphate; Animals; Coronary Circulation; Coronary Vessels; Dogs; Glyburide; Hemodynami | 1993 |
Cardioprotective profile of the cardiac-selective ATP-sensitive potassium channel opener BMS-180448.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Aorta; Benzopyrans; Cromakalim; Decanoic Ac | 1995 |
Ventricular overdrive pacing-induced preconditioning and no-flow ischemia-induced preconditioning in isolated working rat hearts.
Topics: Animals; Benzopyrans; Blood Pressure; Cardiac Pacing, Artificial; Coronary Circulation; Cromakalim; | 1995 |
Intraischemic preconditioning. Increased tolerance to sustained low-flow ischemia by a brief episode of no-flow ischemia without intermittent reperfusion.
Topics: Adenosine Triphosphate; Analysis of Variance; Animals; Chromatography, High Pressure Liquid; Coronar | 1995 |
Ischemic preconditioning attenuates capillary no-reflow induced by prolonged ischemia and reperfusion.
Topics: Adenosine Triphosphate; Animals; Capillaries; Dogs; Female; Glyburide; Guanidines; Male; Muscle, Ske | 1995 |
Blockade of ATP-sensitive potassium channels by 5-hydroxydecanoate suppresses monophasic action potential shortening during regional myocardial ischemia.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bl | 1994 |
Effects of diazoxide on norepinephrine-induced vasocontraction and ischemic myocardium in rats.
Topics: Analysis of Variance; Animals; Aorta, Thoracic; Calcium; Diazoxide; Disease Models, Animal; Dose-Res | 1994 |
Effect of potassium on the action of the KATP modulators cromakalim, pinacidil, or glibenclamide on arrhythmias in isolated perfused rat heart subjected to regional ischaemia.
Topics: Animals; Arrhythmias, Cardiac; Benzopyrans; Cromakalim; Glyburide; Guanidines; Heart; Heart Rate; My | 1994 |
Involvement of activation of ATP-dependent potassium channels in ischemic preconditioning in swine.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Blood Glucose; Coronary Circulation; Coronary Ve | 1994 |
Ketamine-xylazine anaesthesia permits a KATP channel antagonist to attenuate preconditioning in rabbit myocardium.
Topics: Animals; Glyburide; Guanidines; Ketamine; Myocardial Infarction; Myocardial Ischemia; Myocardium; Pi | 1994 |
Enhancement of ischemic myocardial metabolic derangement by glibenclamide.
Topics: Adenosine Monophosphate; Adenosine Triphosphate; Animals; Blood Glucose; Blood Pressure; Disease Mod | 1994 |
Cardioprotection with U-89232 is not reversible with glibenclamide: evidence of a novel anti-ischemic agent derived from cromakalim.
Topics: Animals; Benzopyrans; Cromakalim; Female; Glyburide; Guanidines; Heart; Hemodynamics; Male; Myocardi | 1994 |
Marked activation delay caused by ischemia initiated after regional K+ elevation in in situ pig hearts.
Topics: Animals; Epinephrine; Female; Glyburide; Heart; Heart Conduction System; Male; Myocardial Ischemia; | 1994 |
Effects of ATP-dependent K+ channel modulators on an ischemia-reperfusion rabbit isolated heart model with programmed electrical stimulation.
Topics: Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Benzopyrans; Blood Pressure; Coronary Circula | 1994 |
Blockers of ATP sensitive potassium current are of potential benefit in ischaemic heart disease.
Topics: Anti-Arrhythmia Agents; Glyburide; Humans; Myocardial Ischemia; Potassium Channel Blockers; Sodium-P | 1994 |
A comparison of adenosine-induced cardioprotection and ischemic preconditioning in dogs. Efficacy, time course, and role of KATP channels.
Topics: Adenosine; Adenosine Triphosphate; Animals; Decanoic Acids; Dogs; Female; Glyburide; Hydroxy Acids; | 1994 |
Effect of nicorandil on post-ischaemic contractile dysfunction in the heart: roles of its ATP-sensitive K+ channel opening property and nitrate property.
Topics: Adenosine Triphosphate; Animals; Glyburide; Hemodynamics; Infusions, Intravenous; Ion Channel Gating | 1993 |
Ischemic cardioprotection by ATP-sensitive K+ channels involves high-energy phosphate preservation.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Glyburide; Guanidines; Guinea Pigs; Heart; In Vi | 1993 |
Differential class III and glibenclamide effects on action potential duration in guinea-pig papillary muscle during normoxia and hypoxia/ischaemia.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Electrophysiology; Glyburide; Guinea Pigs; Heart | 1993 |
Glibenclamide, but not class III drugs, prevents ischaemic shortening of the refractory period in guinea-pig hearts.
Topics: Analysis of Variance; Animals; Anti-Arrhythmia Agents; Coronary Circulation; Electrocardiography; Gl | 1993 |
Potassium channel openers and blockers: do they possess proarrhythmic or antiarrhythmic activity in ischemic and reperfused rat hearts?
Topics: Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Arrhythmias, Cardiac; Benzopyrans; Cations | 1993 |
The protection by ischemic preconditioning against myocardial ischemia- and reperfusion-induced arrhythmias is not mediated by ATP-sensitive potassium channels in rats.
Topics: Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Glyburide; Hemodynamics; Male; Myocardial Isc | 1993 |
An explanation for the reported observation that ATP dependent potassium channel openers mimic preconditioning.
Topics: Adenosine Triphosphate; Animals; Dogs; Glyburide; Ion Channel Gating; Myocardial Infarction; Myocard | 1993 |
Pharmacological studies of K+ loss from ischaemic myocardium in vitro: roles of ATP-dependent K+ channels and lactate-coupled efflux.
Topics: Adenosine Triphosphate; Animals; Coumaric Acids; Deoxyglucose; Glyburide; Glycolysis; Guinea Pigs; I | 1993 |
Acetylcholine mimics ischemic preconditioning via a glibenclamide-sensitive mechanism in dogs.
Topics: Acetylcholine; Animals; Coronary Circulation; Dogs; Female; Glyburide; Male; Myocardial Infarction; | 1993 |
Limitation of infarct size in the rabbit by ischaemic preconditioning is reversible with glibenclamide.
Topics: Animals; Blood Glucose; Female; Glyburide; Male; Myocardial Infarction; Myocardial Ischemia; Myocard | 1993 |
Protection from ischaemic-reperfusion injury with adenosine pretreatment is reversed by inhibition of ATP sensitive potassium channels.
Topics: Adenosine; Adenosine Triphosphate; Animals; Disease Models, Animal; Dose-Response Relationship, Drug | 1993 |
Glibenclamide does not abolish the protective effect of preconditioning on stunning in the isolated perfused rat heart.
Topics: Animals; Disease Models, Animal; Glyburide; Hydrogen-Ion Concentration; Magnetic Resonance Spectrosc | 1993 |
Are ATP sensitive potassium channels involved in the pronounced antiarrhythmic effects of preconditioning?
Topics: Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Dogs; Female; Glyburide; Male; Myocardial Isc | 1993 |
Ischaemic preconditioning delays ischaemia induced cellular electrical uncoupling in rabbit myocardium by activation of ATP sensitive potassium channels.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Culture Techniques; Disease Models, Animal; Fema | 1993 |
Blockade of ATP-sensitive potassium channels increases infarct size but does not prevent preconditioning in rabbit hearts.
Topics: Animals; Female; Glyburide; Guanidines; Male; Myocardial Infarction; Myocardial Ischemia; Pinacidil; | 1993 |
Role of ATP-sensitive K+ channel on ECG ST segment elevation during a bout of myocardial ischemia. A study on epicardial mapping in dogs.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Dogs; Electrocardiography; Glyburide; Guanidines | 1993 |
Dissociation between cellular K+ loss, reduction in repolarization time, and tissue ATP levels during myocardial hypoxia and ischemia.
Topics: Action Potentials; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Cell Hypoxia; Glyburide; | 1993 |
Activation of cardiac KATP channels: an endogenous protective mechanism during repetitive ischemia.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Coronary Circulation; Dogs; Female; Glyburide; H | 1993 |
Relationship of severity of myocardial stunning to ATP dependent potassium channel modulation.
Topics: Adenosine Triphosphate; Animals; Coronary Circulation; Dogs; Glyburide; Myocardial Contraction; Myoc | 1993 |
The ATP-sensitive potassium channel blocker glibenclamide (glyburide) does not abolish preconditioning in isolated ischemic rat hearts.
Topics: Adenosine Triphosphate; Animals; Coronary Vessels; Glyburide; Heart; In Vitro Techniques; Male; Myoc | 1993 |
Potassium channels and preconditioning of isolated rabbit cardiomyocytes: effects of glyburide and pinacidil.
Topics: Analysis of Variance; Animals; Cells, Cultured; Glyburide; Guanidines; Heart; Hypoglycemic Agents; K | 1995 |
Preconditioning with potassium channel openers. A new concept for enhancing cardioplegic protection?
Topics: Animals; Coronary Circulation; Glyburide; Heart Arrest, Induced; Male; Myocardial Ischemia; Myocardi | 1995 |
Diabetes and ATP-sensitive potassium channel openers and blockers in isolated ischemic/reperfused hearts.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzopyrans; Cations; | 1995 |
Cardioselective antiischemic ATP-sensitive potassium channel openers. 4. Structure-activity studies on benzopyranylcyanoguanidines: replacement of the benzopyran portion.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cardiotonic Agents; Glyburide; Guanidines; Methoxamine | 1996 |
Reduction by prostaglandin E1 or prostaglandin E0 of myocardial infarct size in the rabbit by activation of ATP-sensitive potassium channels.
Topics: Adenosine Triphosphate; Alprostadil; Animals; Anti-Arrhythmia Agents; Biotransformation; Blood Press | 1995 |
Endothelin-1-induced reduction of myocardial infarct size by activation of ATP-sensitive potassium channels in a rabbit model of myocardial ischaemia and reperfusion.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Arterial Occlusive Diseases; Blood Pressure | 1995 |
Glyburide-reversible cardioprotective effect of BMS-180448 is independent of action potential shortening.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Female; Glyburide; Guan | 1995 |
KATP channel modulation in working rat hearts with coronary occlusion: effects of cromakalim, cicletanine, and glibenclamide.
Topics: Animals; Anti-Arrhythmia Agents; Benzopyrans; Coronary Circulation; Coronary Disease; Cromakalim; Gl | 1995 |
BMS-180448, a novel glyburide-reversible cardioprotective agent, enhances postischemic recovery of contractile function in dogs.
Topics: Animals; Benzopyrans; Cardiotonic Agents; Dogs; Glyburide; Guanidines; Male; Myocardial Contraction; | 1996 |
Morphine mimics the cardioprotective effect of ischemic preconditioning via a glibenclamide-sensitive mechanism in the rat heart.
Topics: Animals; Glyburide; Heart; Hemodynamics; Male; Morphine; Myocardial Ischemia; Naloxone; Potassium Ch | 1996 |
Hypoxic preconditioning in isolated rat hearts: non-involvement of activation of adenosine A1 receptor, Gi protein, and ATP-sensitive K+ channel.
Topics: Adenosine Triphosphate; Analysis of Variance; Animals; Calcium Channel Blockers; Creatine Kinase; Gl | 1995 |
Lack of a pharmacologic interaction between ATP-sensitive potassium channels and adenosine A1 receptors in ischemic rat hearts.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Glyburid | 1996 |
Glyburide-reversible cardioprotective effects of calcium-independent phospholipase A2 inhibition in ischemic rat hearts.
Topics: Animals; Anti-Arrhythmia Agents; Calcium; Coronary Circulation; Decanoic Acids; Dose-Response Relati | 1996 |
Electrophysiologic and extracellular ionic changes during acute ischemia in failing and normal rabbit myocardium.
Topics: Action Potentials; Analysis of Variance; Animals; Electric Stimulation; Glyburide; Heart; In Vitro T | 1996 |
Effect of glibenclamide on ischemic canine myocardium with glucose infusion.
Topics: Animals; Dogs; Energy Metabolism; Female; Glucose; Glyburide; Hemodynamics; Infusions, Intravenous; | 1995 |
KATP channels in rat heart: blockade of ischemic and acetylcholine-mediated preconditioning by glibenclamide.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Glyburide; Heart; Hemodynamics; Myocardial Infarctio | 1996 |
Glibenclamide attenuates peaked T wave in early phase of myocardial ischemia.
Topics: Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Dogs; Electrocardiography; Glyburide; Myocard | 1996 |
ATP-sensitive potassium channels, transmural ischemia and the ECG implications for the non-insulin dependent diabetic patient?
Topics: Adenosine Triphosphate; Diabetes Mellitus, Type 2; Electrocardiography; Glyburide; Humans; Myocardia | 1996 |
PD 81,723, an allosteric enhancer of the A1 adenosine receptor, lowers the threshold for ischemic preconditioning in dogs.
Topics: Allosteric Regulation; Animals; Binding, Competitive; Differential Threshold; Dogs; Female; Glyburid | 1996 |
Glyburide enhancement of lactate production in ischemic heart is modified by preconditioning: an in vivo experimental study in pigs by microdialysis technique.
Topics: Adenosine Triphosphate; Animals; Female; Glyburide; Hypoglycemic Agents; Ischemic Preconditioning, M | 1996 |
Cardioprotective effects of NIP-121, a novel ATP-sensitive potassium channel opener, during ischemia and reperfusion in coronary perfused guinea pig myocardium.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Glyburide; Guinea Pigs; Myocardial Contraction; | 1996 |
Mechanism of myocardial protection by isoflurane. Role of adenosine triphosphate-regulated potassium (KATP) channels.
Topics: Adenosine Triphosphate; Anesthetics, Inhalation; Animals; Coronary Circulation; Dogs; Drug Interacti | 1996 |
Effects of cromakalim and glibenclamide in ischemic and reperfused hearts.
Topics: Animals; Anti-Arrhythmia Agents; Benzopyrans; Cromakalim; Diabetes Mellitus, Experimental; Glyburide | 1996 |
Cardiovascular effects of conventional sulfonylureas and glimepiride.
Topics: Animals; Blood Pressure; Cardiovascular System; Coronary Vessels; Diabetes Mellitus, Experimental; D | 1996 |
Role of activation of ectosolic 5'-nucleotidase in the cardioprotection mediated by opening of K+c channels.
Topics: 5'-Nucleotidase; Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Dogs; Enzyme Activation; | 1996 |
Mechanisms of protection afforded by preconditioning to endothelial function against ischemic injury.
Topics: Adenosine Triphosphate; Animals; Coronary Vessels; Endothelium, Vascular; Glyburide; In Vitro Techni | 1996 |
Y-26763 protects the working rat myocardium from ischemia/reperfusion injury through opening of KATP channels.
Topics: Adenosine Triphosphate; Animals; Antihypertensive Agents; Benzopyrans; Energy Metabolism; Glyburide; | 1996 |
Glyburide-reversible cardioprotective effects of BMS-180448: functional and energetic considerations.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Calcium Channel Blockers; Cardiotonic Agents; Depressi | 1997 |
Increased tolerance of the chronically hypoxic immature heart to ischemia. Contribution of the KATP channel.
Topics: Analysis of Variance; Animals; Animals, Newborn; Benzopyrans; Coronary Circulation; Dihydropyridines | 1997 |
Blockade of ATP-sensitive K+ channel abolishes the anti-ischemic effects of isoflurane in dog hearts.
Topics: Adenosine Triphosphate; Anesthetics, Inhalation; Animals; Dogs; Female; Glyburide; Isoflurane; Male; | 1997 |
Myocardial protection with special reference to ischemic preconditioning. An experimental study in the pig using a microdialysis technique.
Topics: Adenosine; Adenosine Triphosphate; Animals; Glyburide; In Vitro Techniques; Ischemic Preconditioning | 1997 |
Effect of glimepiride and glibenclamide, inhibitors of ATP-dependent K(+)-channel, on ischaemia-reperfusion induced arrhythmias in rats.
Topics: Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Dose-Response Relationship, Drug; Glyburide; | 1996 |
Effects of cromakalim and glibenclamide on myocardial high energy phosphates and intracellular pH during ischemia-reperfusion: 31P NMR studies.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Benzopyrans; Coronary Circulation; Cromakal | 1997 |
Intermittent ischemia: energy metabolism, cellular volume regulation, adenosine and insights into preconditioning.
Topics: Adenosine; Animals; Cell Size; Creatine; Energy Metabolism; Glyburide; Glycogen; Glycolysis; In Vitr | 1997 |
Inhibitory effects of glibenclamide and pertussis toxin on the attenuation of ischemia-induced myocardial acidosis following ischemic preconditioning in dogs.
Topics: Acetylcholine; Acidosis; Adenosine Triphosphate; Animals; Blood Glucose; Blood Pressure; Dogs; Femal | 1997 |
Isoflurane mimics ischemic preconditioning via activation of K(ATP) channels: reduction of myocardial infarct size with an acute memory phase.
Topics: Anesthetics, Inhalation; Animals; Coronary Circulation; Dogs; Glyburide; Hemodynamics; Hypoglycemic | 1997 |
Types of potassium channels involved in coronary reactive hyperemia depend on duration of preceding ischemia in rat hearts.
Topics: 4-Aminopyridine; Adenosine Diphosphate; Animals; Apamin; Charybdotoxin; Glyburide; Hyperemia; In Vit | 1997 |
Mechanism of hypoxic K loss in rabbit ventricle.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Biological Transport; Cromakalim; Glyburide; Heart | 1997 |
ATP-sensitive potassium channel mediates delayed ischemic protection by heat stress in rabbit heart.
Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Decanoic Acids; Glyburide; Heart Rate; Heat Stress | 1997 |
Electrical remodeling due to atrial fibrillation in chronically instrumented conscious goats: roles of neurohumoral changes, ischemia, atrial stretch, and high rate of electrical activation.
Topics: Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Function; Atrial Natriuretic Factor; At | 1997 |
Ventricular fibrillation in preconditioned pig hearts: role of K+ATP channels.
Topics: Action Potentials; Animals; Blood Glucose; Blood Pressure; Glyburide; Heart; Heart Rate; Ischemic Pr | 1997 |
Sulfonylureas and ischemic heart disease.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Glyburide; Heart; Humans; Hypoglycemic Agents | 1998 |
Myocardial ischemic tolerance following heat stress is abolished by ATP-sensitive potassium channel blockade.
Topics: Animals; Blood Pressure; Glyburide; Heart; Heart Rate; Heat Stress Disorders; Male; Myocardial Ische | 1997 |
Cardioprotective effects of KR-30450, a novel K+(ATP) opener, and its major metabolite KR-30818 on isolated rat hearts.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Glyburi | 1998 |
Differential role of epicardial and endocardial K(ATP) channels in potassium accumulation during regional ischemia induced by embolization of a coronary artery with latex.
Topics: Adenosine Triphosphate; Algorithms; Animals; Coronary Vessels; Dogs; Embolization, Therapeutic; Endo | 1998 |
Glibenclamide does not prevent action potential shortening induced by ischemia in anesthetized rabbits but reduces ischemia-induced arrhythmias.
Topics: Action Potentials; Analysis of Variance; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bloo | 1998 |
Oxidant stress with hydrogen peroxide attenuates calcium paradox injury: role of protein kinase C and ATP-sensitive potassium channel.
Topics: Adenosine Triphosphate; Alkaloids; Animals; Anti-Arrhythmia Agents; Benzophenanthridines; Calcium; C | 1998 |
Changes in ventricular repolarization during acidosis and low-flow ischemia.
Topics: Acidosis; Action Potentials; Adenosine Triphosphate; Animals; Decanoic Acids; Ferrets; Glyburide; He | 1998 |
HMR 1883, a novel cardioselective inhibitor of the ATP-sensitive potassium channel. Part II: effects on susceptibility to ventricular fibrillation induced by myocardial ischemia in conscious dogs.
Topics: Adenosine Triphosphate; Animals; Dogs; Glyburide; Heart; Hemodynamics; Myocardial Ischemia; Potassiu | 1998 |
The effects of potassium channel modulators on the simulated ischaemia-induced changes in contractility and responsiveness to phenylephrine of rat-isolated papillary muscle.
Topics: Animals; Chromans; Female; Galanin; Glyburide; Male; Myocardial Contraction; Myocardial Ischemia; Pa | 1998 |
EDRF does not mediate coronary vasodilation secondary to simulated ischemia: a study on KATP channels and N omega-nitro-L-arginine on coronary perfusion pressure in isolated Langendorff-perfused guinea-pig hearts.
Topics: Adenosine Triphosphate; Animals; Coronary Circulation; Enzyme Inhibitors; Glyburide; Guinea Pigs; In | 1998 |
Protein kinase C-dependent activation of KATP channel enhances adenosine-induced cardioprotection.
Topics: Adenosine; Animals; Cells, Cultured; Chick Embryo; Enzyme Activation; Glyburide; Ischemic Preconditi | 1998 |
Biochemical and ultrastructural evaluations of the effect of ischemic preconditioning on ischemic myocardial injury--role of the adenosine triphosphate-sensitive potassium channel.
Topics: Adenosine Triphosphate; Animals; Blood Flow Velocity; Calcium-Transporting ATPases; Coronary Vessels | 1998 |
Blockade of ATP-sensitive K+ channels attenuates preconditioning effect on myocardial metabolism in swine: myocardial metabolism and ATP-sensitive K+ channels.
Topics: Adenosine Triphosphate; Animals; Blood Glucose; Coronary Vessels; Glyburide; Hemodynamics; Hydrogen- | 1998 |
Relevance of inter- and intraventricular electrical dispersion to arrhythmogenesis in normal and ischaemic rabbit myocardium: a study with cromakalim, 5-hydroxydecanoate and glibenclamide.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Coronary Disease; Cromakal | 1999 |
Cardioprotective effect of enantiomers of cicletanine (BN50417, BN50418) in ischaemic/reperfused isolated working rat hearts: interaction with glibenclamide.
Topics: Animals; Antihypertensive Agents; Drug Interactions; Glyburide; Heart; Heart Function Tests; In Vitr | 1999 |
Opioid-induced second window of cardioprotection: potential role of mitochondrial KATP channels.
Topics: Analgesics; Animals; Benzylidene Compounds; Blood Pressure; Coronary Circulation; Glyburide; Hypogly | 1999 |
Adenosine A(3)-receptor stimulation attenuates postischemic dysfunction through K(ATP) channels.
Topics: Adenosine; Adenosine Triphosphate; Animals; Coronary Circulation; Creatine Kinase; Diastole; Glyburi | 1999 |
Levosimendan: effects of a calcium sensitizer on function and arrhythmias and cyclic nucleotide levels during ischemia/reperfusion in the Langendorff-perfused guinea pig heart.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium Channel Agoni | 1999 |
KATP channels and 'border zone' arrhythmias: role of the repolarization dispersion between normal and ischaemic ventricular regions.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; ATP-Binding Cassette Transporters; Benzopyrans; Di | 1999 |
Cardioselective antiischemic ATP-sensitive potassium channel (K(ATP)) openers. 6. Effect of modifications at C6 of benzopyranyl cyanoguanidines.
Topics: Animals; Benzopyrans; Cardiotonic Agents; Glyburide; Guanidines; Heart; Muscle Contraction; Myocardi | 1999 |
Adaptation to high altitude hypoxia protects the rat heart against ischemia-induced arrhythmias. Involvement of mitochondrial K(ATP) channel.
Topics: Acclimatization; Altitude; Animals; Arrhythmias, Cardiac; Glyburide; Heart; Heart Rate; Heart Ventri | 1999 |
HMR 1883, a cardioselective K(ATP) channel blocker, inhibits ischaemia- and reperfusion-induced ventricular fibrillation in rats.
Topics: Adenosine Triphosphate; Administration, Oral; Animals; Arrhythmias, Cardiac; Arterial Occlusive Dise | 1999 |
Preconditioning reduces tissue complement gene expression in the rabbit isolated heart.
Topics: Animals; Complement System Proteins; DNA Primers; Gene Expression Regulation; Glyburide; In Vitro Te | 1999 |
Direct myocardial anti-ischaemic effect of GTN in both nitrate-tolerant and nontolerant rats: a cyclic GMP-independent activation of KATP.
Topics: Adenosine Triphosphate; Animals; Coronary Circulation; Cyclic AMP; Glyburide; Heart; Hypoglycemic Ag | 1999 |
Intracellular Ca2+ and delay of ischemia-induced electrical uncoupling in preconditioned rabbit ventricular myocardium.
Topics: Adenosine Triphosphate; Animals; Calcium; Calcium Channel Blockers; Enzyme Activation; Enzyme Inhibi | 1999 |
K(ATP) channel blocker HMR 1883 reduces monophasic action potential shortening during coronary ischemia in anesthetised pigs.
Topics: Action Potentials; Anesthesia; Animals; Anti-Arrhythmia Agents; Glyburide; Guinea Pigs; Heart; Male; | 2000 |
Evidence for mitochondrial K ATP channels as effectors of human myocardial preconditioning.
Topics: Analysis of Variance; Cell Membrane; Decanoic Acids; Diazoxide; Dose-Response Relationship, Drug; Gl | 2000 |
Nitric oxide-induced cardioprotection in cultured rat ventricular myocytes.
Topics: Alkaloids; Animals; Animals, Newborn; Anti-Infective Agents; Benzophenanthridines; Cells, Cultured; | 2000 |
Blockade of adenosine triphosphate-sensitive potassium channels by thiamylal in rat ventricular myocytes.
Topics: 2,4-Dinitrophenol; Anesthetics, Intravenous; Animals; ATP-Binding Cassette Transporters; Cell Separa | 2000 |
Role of the Na(+)/H(+) exchanger in short-term atrial electrophysiological remodeling.
Topics: Analysis of Variance; Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Dogs; Electrophysiology; | 2000 |
Fibroblast growth factor cardioprotection against ischemia-reperfusion injury may involve K+ ATP channels.
Topics: Adenosine Triphosphate; Animals; Creatine Kinase; Enzyme Activation; Fibroblast Growth Factor 1; Fib | 2000 |
Effects of the I(K.ATP) blockers glibenclamide and HMR1883 on cardiac electrophysiology during ischemia and reperfusion.
Topics: Animals; Arrhythmias, Cardiac; Electrocardiography; Electrophysiology; Glyburide; Heart; In Vitro Te | 2000 |
Block of cardiac ATP-sensitive K(+) channels reduces hydroxyl radicals in the rat myocardium.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Cromakalim; Decano | 2000 |
Do KATP channels open as a prominent and early feature during ischaemia in the Langendorff-perfused rat heart?
Topics: Action Potentials; Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Benzopyrans; Coronary Dise | 2000 |
Coronary vascular K+ATP channels contribute to the maintenance of myocardial perfusion in dogs with pacing-induced heart failure.
Topics: Adenosine Triphosphate; Animals; Coronary Circulation; Coronary Vessels; Dogs; Dose-Response Relatio | 2000 |
Increased mitochondrial K(ATP) channel activity during chronic myocardial hypoxia: is cardioprotection mediated by improved bioenergetics?
Topics: Adaptation, Physiological; Adenosine Triphosphate; Animals; Animals, Newborn; Benzopyrans; Cell Hypo | 2000 |
The role of K+ATP channels in the control of pre- and post-ischemic left ventricular developed pressure in septic rat hearts.
Topics: Animals; ATP-Binding Cassette Transporters; Blood Pressure; Coronary Circulation; Cromakalim; Escher | 2001 |
A K(ATP) channel opener inhibited myocardial reperfusion action potential shortening and arrhythmias.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Antihypertensive Agents; Arrhythmias, Cardiac; B | 2001 |
Pharmacologic characterization of BMS-191095, a mitochondrial K(ATP) opener with no peripheral vasodilator or cardiac action potential shortening activity.
Topics: Action Potentials; Animals; Benzopyrans; Cardiovascular Agents; Cromakalim; Decanoic Acids; Dose-Res | 2001 |
Glibenclamide effects on reperfusion-induced malignant arrhythmias and left ventricular mechanical recovery from stunning in conscious sheep.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Glyburide; Hemodynamics; H | 2001 |
Glimepiride, a novel sulfonylurea, does not abolish myocardial protection afforded by either ischemic preconditioning or diazoxide.
Topics: Animals; Diazoxide; Glyburide; Guanosine Triphosphate; Heart; Heart Ventricles; Hemodynamics; Hypogl | 2001 |
Effects of the cardioselective KATP channel blocker HMR 1098 on cardiac function in isolated perfused working rat hearts and in anesthetized rats during ischemia and reperfusion.
Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Benzamides; Glyburide; Heart; Hemodynamics; In Vitro Te | 2001 |
K(ATP) channel opening during ischemia: effects on myocardial noradrenaline release and ventricular arrhythmias.
Topics: Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Coronary Circulation; Cromakalim; Female; Gly | 2001 |
Activation of ATP-sensitive potassium channels in hypoxic cardiac failure is not mediated by adenosine-1 receptors in the isolated rat heart.
Topics: Action Potentials; Animals; Blood Pressure; Female; Glyburide; Heart Rate; Hypoglycemic Agents; Hypo | 2001 |
Ischemic preconditioning attenuates cardiac sympathetic nerve injury via ATP-sensitive potassium channels during myocardial ischemia.
Topics: Adenosine Triphosphate; Animals; Coronary Circulation; Desipramine; Dialysis Solutions; Diltiazem; D | 2001 |
Glibenclamide improves postischemic recovery of myocardial contractile function in trained and sedentary rats.
Topics: Animals; ATP-Binding Cassette Transporters; Calcium; Coronary Circulation; Female; Glyburide; Heat-S | 2001 |
Relation of cyclic nucleotide ratios to ischemic and reperfusion injury in nitric oxide-donor treated rat hearts.
Topics: Animals; Anti-Arrhythmia Agents; Glyburide; In Vitro Techniques; Male; Myocardial Contraction; Myoca | 2001 |
Role of cardiac ATP-sensitive K+ channels induced by HMG CoA reductase inhibitor in ischemic rabbit hearts.
Topics: Adenosine Triphosphate; Animals; Enzyme Inhibitors; Glyburide; Hydroxymethylglutaryl-CoA Reductase I | 2001 |
Glibenclamide attenuates ischemia-induced acidosis and loss of cardiac function in rats.
Topics: Acidosis; Adenosine Triphosphate; Animals; Coronary Circulation; Glyburide; Glycolysis; Hydrogen-Ion | 2002 |
Mechanisms of the effects of nicorandil in the isolated rat heart during ischemia and reperfusion: a 31P-nuclear magnetic resonance study.
Topics: Animals; Anti-Arrhythmia Agents; Coronary Circulation; Glyburide; Heart; Hydrogen-Ion Concentration; | 2001 |
Nicorandil attenuates myocardial dysfunction associated with transient ischemia by opening ATP-dependent potassium channels.
Topics: Adenosine Triphosphate; Animals; Blood Glucose; Blood Pressure; Coronary Circulation; Dogs; Female; | 1992 |
Influence of KATP channel modulation on net potassium efflux from ischaemic mammalian cardiac tissue.
Topics: Action Potentials; Animals; Barium; Benzopyrans; Cromakalim; Glyburide; Guinea Pigs; Hydrogen-Ion Co | 1992 |
Effects of intracoronary cromakalim on postischaemic contractile function and action potential duration.
Topics: Action Potentials; Animals; Benzopyrans; Blood Pressure; Coronary Circulation; Coronary Vessels; Cro | 1992 |
Effects of potassium channel modulation during global ischaemia in isolated rat heart with and without cardioplegia.
Topics: Animals; Benzopyrans; Blood Pressure; Coronary Circulation; Coronary Vessels; Cromakalim; Glyburide; | 1992 |
Blockade of ischaemic preconditioning in dogs by the novel ATP dependent potassium channel antagonist sodium 5-hydroxydecanoate.
Topics: Animals; Benzopyrans; Blood Glucose; Blood Pressure; Coronary Circulation; Coronary Vessels; Decanoi | 1992 |
Effects of glibenclamide on ventricular arrhythmias and cardiac function in ischaemia and reperfusion in isolated rat heart.
Topics: Animals; Arrhythmias, Cardiac; Blood Pressure; Coronary Circulation; Coronary Vessels; Glyburide; He | 1992 |
Glibenclamide and cardiac function during ischaemia.
Topics: Glyburide; Humans; Myocardial Contraction; Myocardial Ischemia; Potassium Channels | 1992 |
Effects of drugs on ventricular fibrillation and ischaemic K+ loss in a model of ischaemia in perfused guinea-pig hearts in vitro.
Topics: 4-Aminopyridine; Animals; Anti-Arrhythmia Agents; Benzothiazoles; Calcium Channel Blockers; Disease | 1992 |
Influence of ATP-sensitive potassium channel blocker on hypoxia-induced damage of isolated guinea pig heart.
Topics: Adenosine Triphosphate; Animals; Glyburide; Guinea Pigs; Heart Rate; Hypoxia; L-Lactate Dehydrogenas | 1992 |
Effect of the potassium channel opener EMD 56431 on globally ischemic rat hearts.
Topics: Animals; Benzopyrans; Coronary Circulation; Glyburide; Hemodynamics; L-Lactate Dehydrogenase; Male; | 1992 |