glyburide has been researched along with Insulinoma in 43 studies
Glyburide: An antidiabetic sulfonylurea derivative with actions like those of chlorpropamide
glyburide : An N-sulfonylurea that is acetohexamide in which the acetyl group is replaced by a 2-(5-chloro-2-methoxybenzamido)ethyl group.
Insulinoma: A benign tumor of the PANCREATIC BETA CELLS. Insulinoma secretes excess INSULIN resulting in HYPOGLYCEMIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Thus, alpha-TC glucagonoma cells contain ATP-sensitive K+ channels that regulate glucagon release, yet allow inhibition of hormone release by glucose." | 5.29 | Sulfonylurea-binding sites and ATP-sensitive K+ channels in alpha-TC glucagonoma and beta-TC insulinoma cells. ( Buettger, C; Epstein, AJ; Hang, TL; Matschinsky, FM; Ronner, P, 1993) |
| "We have used hamster insulinoma tumor (HIT) cells, an insulin-secreting tumor cell line, to investigate modulation of the Na/K-ATPase and of the ATP-sensitive K channel (K(ATP)) by the sulfonylurea glyburide." | 3.69 | Sulfonylurea binding to a low-affinity site inhibits the Na/K-ATPase and the KATP channel in insulin-secreting cells. ( Johnson, DG; Levin, SR; Mirell, CJ; Ribalet, B, 1996) |
| "In insulinoma cells (RINm5F), the glibenclamide-sensitive K-current (IK(ATP)) which developed spontaneously or after exposure to levcromakalim or to butanedione monoxime was always accompanied by a reduction in the delayed rectifier current (IK(V))." | 3.68 | Induction of a glibenclamide-sensitive K-current by modification of a delayed rectifier channel in rat portal vein in insulinoma cells. ( Edwards, G; Weston, AH, 1993) |
| "Cell membranes isolated from hamster insulinoma (HIT T15) cells at passages 65-74 contain high and low affinity receptors for a sulfonylurea derivative, 5-[125I]iodo,2-hydroxyglyburide (KD values of approximately 7 nM and 16 microM)." | 3.68 | Co-expression of sulfonylurea receptors and KATP channels in hamster insulinoma tumor (HIT) cells. Evidence for direct association of the receptor with the channel. ( Aguilar-Bryan, L; Bryan, J; Nichols, CG; Parker, C; Rajan, AS, 1992) |
| "Gatifloxacin can cause both hypoglycemia and hyperglycemia in both diabetic and non-diabetic patients." | 1.33 | Gatifloxacin acutely stimulates insulin secretion and chronically suppresses insulin biosynthesis. ( Inagaki, N; Kawasaki, Y; Nagashima, K; Seino, Y; Takahashi, A; Ueno, H; Yamada, C; Yamada, Y, 2006) |
| "Thus, alpha-TC glucagonoma cells contain ATP-sensitive K+ channels that regulate glucagon release, yet allow inhibition of hormone release by glucose." | 1.29 | Sulfonylurea-binding sites and ATP-sensitive K+ channels in alpha-TC glucagonoma and beta-TC insulinoma cells. ( Buettger, C; Epstein, AJ; Hang, TL; Matschinsky, FM; Ronner, P, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (25.58) | 18.7374 |
| 1990's | 19 (44.19) | 18.2507 |
| 2000's | 9 (20.93) | 29.6817 |
| 2010's | 4 (9.30) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ruan, JS | 1 |
| Lin, JK | 1 |
| Kuo, YY | 1 |
| Chen, YW | 1 |
| Chen, PC | 1 |
| Luppi, P | 1 |
| Drain, P | 1 |
| Lamprianou, S | 1 |
| Gysemans, C | 1 |
| Bou Saab, J | 1 |
| Pontes, H | 1 |
| Mathieu, C | 1 |
| Meda, P | 1 |
| Adebajo, AC | 1 |
| Ayoola, MD | 1 |
| Odediran, SA | 1 |
| Aladesanmi, AJ | 1 |
| Schmidt, TJ | 1 |
| Verspohl, EJ | 2 |
| Ichikawa, K | 1 |
| Yamato, T | 1 |
| Tsuji, A | 1 |
| Ojima, K | 1 |
| Kusama, H | 1 |
| Kojima, M | 1 |
| Mendez, CF | 1 |
| Leibiger, IB | 1 |
| Leibiger, B | 1 |
| Høy, M | 1 |
| Gromada, J | 2 |
| Berggren, PO | 2 |
| Bertorello, AM | 1 |
| Hussain, Z | 1 |
| Waheed, A | 1 |
| Qureshi, RA | 1 |
| Burdi, DK | 1 |
| Khan, N | 1 |
| Hasan, M | 1 |
| Park, KH | 2 |
| Akaike, T | 1 |
| Yamada, C | 1 |
| Nagashima, K | 1 |
| Takahashi, A | 1 |
| Ueno, H | 1 |
| Kawasaki, Y | 1 |
| Yamada, Y | 2 |
| Seino, Y | 2 |
| Inagaki, N | 1 |
| Harrop, JS | 1 |
| Golding, PR | 1 |
| Goodall, P | 1 |
| Leveau, VM | 1 |
| Steele, GA | 1 |
| Ingle, AR | 1 |
| De Stefanis, P | 1 |
| Impagnatiello, F | 1 |
| Berkovich, A | 1 |
| Guidotti, A | 1 |
| Khan, RN | 1 |
| Hales, CN | 3 |
| Ozanne, SE | 2 |
| Adogu, AA | 1 |
| Ashford, ML | 2 |
| Guest, PC | 1 |
| Hutton, JC | 1 |
| Mogami, H | 1 |
| Shibata, H | 1 |
| Nobusawa, R | 1 |
| Ohnota, H | 1 |
| Satou, F | 1 |
| Miyazaki, J | 1 |
| Kojima, I | 1 |
| Guillemare, E | 1 |
| Honore, E | 1 |
| De Weille, J | 4 |
| Fosset, M | 7 |
| Lazdunski, M | 8 |
| Meisheri, K | 1 |
| Ronner, P | 1 |
| Matschinsky, FM | 1 |
| Hang, TL | 1 |
| Epstein, AJ | 1 |
| Buettger, C | 1 |
| Edwards, G | 1 |
| Weston, AH | 1 |
| Gaich, G | 1 |
| Orloff, JJ | 1 |
| Atillasoy, EJ | 1 |
| Burtis, WJ | 1 |
| Ganz, MB | 1 |
| Stewart, AF | 1 |
| Sjöholm, A | 1 |
| Arkhammar, P | 1 |
| Welsh, N | 1 |
| Bokvist, K | 1 |
| Rorsman, P | 1 |
| Hallberg, A | 1 |
| Nilsson, T | 1 |
| Welsh, M | 1 |
| Hoffman, FJ | 1 |
| Lenfers, JB | 1 |
| Niemers, E | 1 |
| Pleiss, U | 1 |
| Scriabine, A | 1 |
| Janis, RA | 1 |
| Ribalet, B | 1 |
| Mirell, CJ | 1 |
| Johnson, DG | 1 |
| Levin, SR | 1 |
| Springborg, J | 1 |
| Madsen, P | 1 |
| Varming, AR | 1 |
| Fuhlendorff, J | 1 |
| Tian, YA | 1 |
| Johnson, G | 1 |
| Ashcroft, SJ | 1 |
| Miller, TR | 1 |
| Taber, RD | 1 |
| Molinari, EJ | 1 |
| Whiteaker, KL | 1 |
| Monteggia, LM | 1 |
| Scott, VE | 1 |
| Brioni, JD | 1 |
| Sullivan, JP | 1 |
| Gopalakrishnan, M | 1 |
| Akiyoshi, H | 1 |
| Iwamoto, M | 1 |
| Nakaya, Y | 1 |
| Iwakura, T | 1 |
| Fujimoto, S | 1 |
| Kagimoto, S | 1 |
| Inada, A | 1 |
| Kubota, A | 1 |
| Someya, Y | 1 |
| Ihara, Y | 1 |
| Kulkarni, RN | 1 |
| Wang, ZL | 1 |
| Wang, RM | 1 |
| Smith, DM | 1 |
| Ghatei, MA | 1 |
| Bloom, SR | 1 |
| Kim, SW | 1 |
| Bae, YH | 1 |
| MacDonald, PE | 1 |
| Ha, XF | 1 |
| Wang, J | 1 |
| Smukler, SR | 1 |
| Sun, AM | 1 |
| Gaisano, HY | 1 |
| Salapatek, AM | 1 |
| Backx, PH | 1 |
| Wheeler, MB | 1 |
| de Weille, JR | 4 |
| Müller, M | 1 |
| Murakami, M | 1 |
| Ishizuka, J | 1 |
| Sumi, S | 1 |
| Nickols, GA | 1 |
| Cooper, CW | 1 |
| Townsend, CM | 1 |
| Thompson, JC | 1 |
| Aguilar-Bryan, L | 1 |
| Nichols, CG | 1 |
| Rajan, AS | 1 |
| Parker, C | 1 |
| Bryan, J | 1 |
| French, JF | 1 |
| Riera, LC | 1 |
| Mullins, UL | 1 |
| Sarmiento, JG | 1 |
| Sturgess, NC | 1 |
| Cook, DL | 1 |
| Schmid-Antomarchi, H | 6 |
| Green, RD | 1 |
| Kramer, W | 1 |
| Oekonomopulos, R | 1 |
| Pünter, J | 2 |
| Summ, HD | 2 |
| Flatt, PR | 1 |
| Tan, KS | 1 |
| Swanston-Flatt, SK | 1 |
| Webster, JD | 1 |
| Marks, V | 1 |
| Geisen, K | 1 |
| Hitzel, V | 1 |
| Okomonopoulos, R | 1 |
| Weyer, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| TArgeting Type 1 Diabetes Using POLyamines (TADPOL): A Randomized, Double-Masked, Placebo-Controlled Phase 2 Study to Evaluate the Efficacy and Safety of Difluoromethylornithine (DFMO) to Preserve Insulin Production in Type 1 Diabetes[NCT05594563] | Phase 2 | 70 participants (Anticipated) | Interventional | 2023-03-14 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for glyburide and Insulinoma
| Article | Year |
|---|---|
Pharmacological and molecular characterization of ATP-sensitive K+ channels in the TE671 human medulloblastoma cell line.
Topics: Adenosine Triphosphate; Animals; Barbiturates; Cells, Cultured; Cromakalim; Fluorescent Dyes; Fluoro | 1999 |
42 other studies available for glyburide and Insulinoma
| Article | Year |
|---|---|
Chronic palmitic acid-induced lipotoxicity correlates with defective trafficking of ATP sensitive potassium channels in pancreatic β cells.
Topics: Animals; Cell Line, Tumor; Diabetes Mellitus, Experimental; Glyburide; Insulin-Secreting Cells; Insu | 2018 |
Autocrine C-peptide mechanism underlying INS1 beta cell adaptation to oxidative stress.
Topics: Adaptation, Physiological; Animals; Apoptosis; Autocrine Communication; C-Peptide; Cell Line, Tumor; | 2014 |
Glibenclamide Prevents Diabetes in NOD Mice.
Topics: Animals; Cells, Cultured; Cytokines; Diabetes Mellitus, Type 1; Female; Glyburide; Hypoglycemic Agen | 2016 |
Evaluation of ethnomedical claim III: anti-hyperglycemic activities of Gongronema latifolium root and stem.
Topics: Animals; Apocynaceae; Blood Glucose; Cell Line, Tumor; Chromatography, Liquid; Drug Evaluation, Prec | 2013 |
Study of the insulinotropic effect of the novel antihyperglycemic agent KAD-1229 using HIT T15 cells, a hamster's insulinoma cell line.
Topics: Animals; Calcium Channel Blockers; Cell Line; Cell Membrane; Cricetinae; Glucose; Glyburide; Hypogly | 2002 |
Rapid association of protein kinase C-epsilon with insulin granules is essential for insulin exocytosis.
Topics: Animals; Cells, Cultured; Cytoplasmic Granules; Electric Capacitance; Exocytosis; Glucose; Glyburide | 2003 |
The effect of medicinal plants of Islamabad and Murree region of Pakistan on insulin secretion from INS-1 cells.
Topics: Animals; Cell Line; Diabetes Mellitus; Dose-Response Relationship, Drug; Flowers; Fruit; Glyburide; | 2004 |
Probing of specific binding of synthetic sulfonylurea with the insulinoma cell line MIN6.
Topics: Calcium; Diazoxide; Glyburide; Hypoglycemic Agents; Insulinoma; Microscopy, Confocal; Pancreatic Neo | 2005 |
Gatifloxacin acutely stimulates insulin secretion and chronically suppresses insulin biosynthesis.
Topics: Animals; Anti-Infective Agents; Blood Glucose; Cell Line, Tumor; Cell Separation; Fluoroquinolones; | 2006 |
C-peptide suppression test and sulphonylurea-induced factitious hypoglycaemia.
Topics: Adult; C-Peptide; Diagnosis, Differential; Factitious Disorders; Glyburide; Humans; Hypoglycemia; In | 1982 |
Inhibitory effect of ODN, a naturally occurring processing product of diazepam binding inhibitor, on secretagogues-induced insulin secretion.
Topics: 1-Methyl-3-isobutylxanthine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifl | 1995 |
Dissociation of KATP channel and sulphonylurea receptor in the rat clonal insulin-secreting cell line, CRI-D11.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Cel | 1993 |
Intracellular localization and molecular heterogeneity of the sulphonylurea receptor in insulin-secreting cells.
Topics: Animals; ATP-Binding Cassette Transporters; Binding Sites; Biomarkers; Cell Fractionation; Cell Memb | 1995 |
Inhibition of ATP-sensitive K+ channel by a non-sulfonylurea compound KAD-1229 in a pancreatic beta-cell line, MIN 6 cell.
Topics: Action Potentials; Adenosine Triphosphate; Binding, Competitive; Calcium; Cell Membrane; Cobalt; Dos | 1994 |
Functional receptors in Xenopus oocytes for U-37883A, a novel ATP-sensitive K+ channel blocker: comparison with rat insulinoma cells.
Topics: Adamantane; Adenosine Triphosphate; Animals; Binding Sites; Female; Glyburide; Insulinoma; Morpholin | 1994 |
Sulfonylurea-binding sites and ATP-sensitive K+ channels in alpha-TC glucagonoma and beta-TC insulinoma cells.
Topics: Adenosine Triphosphate; Animals; Binding Sites; Binding, Competitive; Diazoxide; Glucagon; Glucagono | 1993 |
Induction of a glibenclamide-sensitive K-current by modification of a delayed rectifier channel in rat portal vein in insulinoma cells.
Topics: Animals; Benzopyrans; Cromakalim; Glyburide; Insulinoma; Neurotoxins; Phosphorylation; Portal Vein; | 1993 |
Amino-terminal parathyroid hormone-related protein: specific binding and cytosolic calcium responses in rat insulinoma cells.
Topics: Animals; Binding Sites; Calcium; Cell Membrane; Cyclic AMP; Cytosol; Glucagon; Glucagon-Like Peptide | 1993 |
Enhanced stimulus-secretion coupling in polyamine-depleted rat insulinoma cells. An effect involving increased cytoplasmic Ca2+, inositol phosphate generation, and phorbol ester sensitivity.
Topics: Adenosine Triphosphate; Animals; Calcium; Calcium Channels; Carbachol; Cytoplasm; Diazoxide; DNA, Ne | 1993 |
High affinity binding of a potassium channel agonist to intact rat insulinoma cells.
Topics: Animals; Aorta; Binding Sites; Binding, Competitive; Glyburide; Guanidines; Insulinoma; Kinetics; Ma | 1993 |
Sulfonylurea binding to a low-affinity site inhibits the Na/K-ATPase and the KATP channel in insulin-secreting cells.
Topics: Adenosine Triphosphate; Animals; Cricetinae; Glucose; Glyburide; Hypoglycemic Agents; Insulin; Insul | 1996 |
Increase in [Ca2+]i and subsequent insulin release from beta TC3-cells with the L-type Ca(2+)-channel activator, FPL 64176.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1997 |
Sulfonylureas enhance exocytosis from pancreatic beta-cells by a mechanism that does not involve direct activation of protein kinase C.
Topics: Animals; Calcium; Enzyme Activation; Exocytosis; Glyburide; Guanosine 5'-O-(3-Thiotriphosphate); Hyp | 1998 |
Lactate stimulates insulin secretion without blocking the K+ channels in HIT-T15 insulinoma cells.
Topics: Adenosine Triphosphate; Animals; Calcium; Calcium Radioisotopes; Cricetinae; Cytosol; Electrophysiol | 1999 |
Sustained enhancement of Ca(2+) influx by glibenclamide induces apoptosis in RINm5F cells.
Topics: Animals; Apoptosis; Calcium; Cell Survival; Dose-Response Relationship, Drug; Glyburide; Hypoglycemi | 2000 |
Glibenclamide but not other sulphonylureas stimulates release of neuropeptide Y from perifused rat islets and hamster insulinoma cells.
Topics: Animals; Blotting, Northern; Cricetinae; Glyburide; Hypoglycemic Agents; Insulin; Insulin Secretion; | 2000 |
Interaction of sulfonylurea-conjugated polymer with insulinoma cell line of MIN6 and its effect on insulin secretion.
Topics: Acrylic Resins; Animals; Biocompatible Materials; Culture Media, Conditioned; Diazoxide; Glucose; Gl | 2001 |
Members of the Kv1 and Kv2 voltage-dependent K(+) channel families regulate insulin secretion.
Topics: 1-Methyl-3-isobutylxanthine; Adenoviridae; Animals; Cell Line; Cyclic AMP-Dependent Protein Kinases; | 2001 |
Activation and inhibition of ATP-sensitive K+ channels by fluorescein derivatives.
Topics: Adenosine Triphosphate; Animals; Biological Transport; Eosine I Bluish; Fluorescein; Fluoresceins; G | 1992 |
Role of extracellular magnesium in insulin secretion from rat insulinoma cells.
Topics: Animals; Calcium; Cell Line; Colforsin; Glyburide; Glyceraldehyde; Insulin; Insulin Secretion; Insul | 1992 |
Co-expression of sulfonylurea receptors and KATP channels in hamster insulinoma tumor (HIT) cells. Evidence for direct association of the receptor with the channel.
Topics: Adenosine Triphosphate; Affinity Labels; Animals; ATP-Binding Cassette Transporters; Autoradiography | 1992 |
Modulation of [3H]glibenclamide binding to cardiac and insulinoma membranes.
Topics: Animals; Cations, Divalent; Dogs; Female; Glyburide; Guanosine 5'-O-(3-Thiotriphosphate); Guanylyl I | 1991 |
K-channels in an insulin-secreting cell line: effects of ATP and sulphonylureas.
Topics: Adenosine Triphosphate; Animals; Cell Line; Glucose; Glyburide; Insulin; Insulin Secretion; Insulino | 1986 |
The antidiabetic sulfonylurea glibenclamide is a potent blocker of the ATP-modulated K+ channel in insulin secreting cells.
Topics: Adenosine Triphosphate; Animals; Electrophysiology; Glyburide; Insulin; Insulin Secretion; Insulinom | 1987 |
The receptor for antidiabetic sulfonylureas controls the activity of the ATP-modulated K+ channel in insulin-secreting cells.
Topics: Adenoma, Islet Cell; Adenosine Triphosphate; Animals; Binding, Competitive; Cell Line; Glyburide; Hy | 1987 |
ATP-sensitive K+ channels that are blocked by hypoglycemia-inducing sulfonylureas in insulin-secreting cells are activated by galanin, a hyperglycemia-inducing hormone.
Topics: Action Potentials; Adenoma, Islet Cell; Adenosine Triphosphate; Animals; Calcium; Drug Interactions; | 1988 |
Antidiabetic sulfonylureas control action potential properties in heart cells via high affinity receptors that are linked to ATP-dependent K+ channels.
Topics: Action Potentials; Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Chickens; Ele | 1988 |
Regulation of ATP-sensitive K+ channels in insulinoma cells: activation by somatostatin and protein kinase C and the role of cAMP.
Topics: Adenoma, Islet Cell; Adenosine Triphosphate; Animals; Cyclic AMP; Glyburide; Insulinoma; Pertussis T | 1989 |
Direct photoaffinity labeling of the putative sulfonylurea receptor in rat beta-cell tumor membranes by [3H]glibenclamide.
Topics: Adenoma, Islet Cell; Animals; ATP-Binding Cassette Transporters; Cell Membrane; Glyburide; Insulinom | 1988 |
Metabolic effects and secretory properties of a radiation-induced transplantable rat insulinoma.
Topics: Adenoma, Islet Cell; Animals; Arginine; Blood Glucose; Body Weight; Deoxyglucose; Epinephrine; Feedi | 1987 |
Somatostatin activates glibenclamide-sensitive and ATP-regulated K+ channels in insulinoma cells via a G-protein.
Topics: Adenosine Triphosphate; Animals; Deoxyglucose; Glyburide; GTP-Binding Proteins; Insulinoma; Oligomyc | 1988 |
Inhibition of 3H-glibenclamide binding to sulfonylurea receptors by oral antidiabetics.
Topics: Animals; Binding, Competitive; Blood Glucose; Cerebral Cortex; Female; Glyburide; Hypoglycemic Agent | 1985 |