glyburide has been researched along with Innate Inflammatory Response in 41 studies
Glyburide: An antidiabetic sulfonylurea derivative with actions like those of chlorpropamide
glyburide : An N-sulfonylurea that is acetohexamide in which the acetyl group is replaced by a 2-(5-chloro-2-methoxybenzamido)ethyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We compared the vascular effects of rosiglitazone versus glyburide and evaluated asymmetric dimethylarginine (ADMA) and oxidative stress as potential mechanisms associated with changes in vascular health in patients with type 2 diabetes mellitus (T2DM)." | 9.12 | Rosiglitazone improves endothelial function and inflammation but not asymmetric dimethylarginine or oxidative stress in patients with type 2 diabetes mellitus. ( Bank, AJ; Gonzalez-Campoy, JM; Kaiser, DR; Kelly, AS; Thelen, AM, 2007) |
| "As a serotonin antagonist, tropisetron positively affects blood glucose lowering, insulin synthesis, pancreas inflammation, and apoptosis in diabetes." | 8.31 | Tropisetron improved testicular inflammation in the streptozotocin-induced diabetic rats: The role of toll-like receptor 4 (TLR4) and mir146a. ( Moslehi, A; Naderi, R; Pourheydar, B, 2023) |
| "Glyburide is a classic antidiabetic drug that is dominant in inflammation regulation, but its specific role in ozone-induced lung inflammation and injury remains unclear." | 7.96 | Glyburide attenuates ozone-induced pulmonary inflammation and injury by blocking the NLRP3 inflammasome. ( Ba, Y; Chen, X; Duan, S; Feng, F; Gao, M; Huang, L; Li, C; Liu, H; Shao, H; Wang, J; Wang, W; Wang, X; Wang, Z; Wu, W; Yang, Z; Zhang, Q; Zhang, R; Zhu, J; Zhu, Y, 2020) |
| "This study investigated the role of K(ATP) channels in morphine-induced antinociception and hepatic oxidative stress in acute and inflammatory pain." | 7.79 | The involvement of K(ATP) channels in morphine-induced antinociception and hepatic oxidative stress in acute and inflammatory pain in rats. ( Afify, EA; Khedr, MM; Nasser, SA; Omar, AG, 2013) |
| "The prevalence of nonalcoholic fatty liver disease (NAFLD) is much higher in patients with type II diabetes (T2D)." | 5.91 | Dimethyl fumarate-mediated Nrf2/ARE pathway activation and glibenclamide-mediated NLRP3 inflammasome cascade inhibition alleviate type II diabetes-associated fatty liver in rats by mitigating oxidative stress and inflammation. ( Dwivedi, DK; Jena, GB, 2023) |
| "Glyburide (Gly) could inhibit NLRP3 inflammasome, as well as could be treated with Type 2 diabetes as a common medication." | 5.62 | Glyburide attenuates B(a)p and LPS-induced inflammation-related lung tumorigenesis in mice. ( Feng, F; Gao, M; Huang, L; Li, M; Liu, H; Shang, P; Shao, H; Wang, W; Zhang, P; Zhang, Q, 2021) |
| "We compared the vascular effects of rosiglitazone versus glyburide and evaluated asymmetric dimethylarginine (ADMA) and oxidative stress as potential mechanisms associated with changes in vascular health in patients with type 2 diabetes mellitus (T2DM)." | 5.12 | Rosiglitazone improves endothelial function and inflammation but not asymmetric dimethylarginine or oxidative stress in patients with type 2 diabetes mellitus. ( Bank, AJ; Gonzalez-Campoy, JM; Kaiser, DR; Kelly, AS; Thelen, AM, 2007) |
| " We compared the effects of two insulin secretagogues, repaglinide and glyburide, known to have different efficacy on postprandial hyperglycemia, on carotid intima-media thickness (CIMT) and markers of systemic vascular inflammation in type 2 diabetic patients." | 5.11 | Regression of carotid atherosclerosis by control of postprandial hyperglycemia in type 2 diabetes mellitus. ( Esposito, K; Giugliano, D; Marfella, R; Nappo, F, 2004) |
| "As a serotonin antagonist, tropisetron positively affects blood glucose lowering, insulin synthesis, pancreas inflammation, and apoptosis in diabetes." | 4.31 | Tropisetron improved testicular inflammation in the streptozotocin-induced diabetic rats: The role of toll-like receptor 4 (TLR4) and mir146a. ( Moslehi, A; Naderi, R; Pourheydar, B, 2023) |
| "Pyroptosis was involved in bone loss induced by occlusal trauma with or without periodontitis, while glyburide reversed inflammation and bone resorption." | 4.12 | Study on the role of pyroptosis in bone resorption induced by occlusal trauma with or without periodontitis. ( Jiang, M; Liang, X; Shang, Z; Sun, H; Yin, X; Zhang, T, 2022) |
| "Glyburide is a classic antidiabetic drug that is dominant in inflammation regulation, but its specific role in ozone-induced lung inflammation and injury remains unclear." | 3.96 | Glyburide attenuates ozone-induced pulmonary inflammation and injury by blocking the NLRP3 inflammasome. ( Ba, Y; Chen, X; Duan, S; Feng, F; Gao, M; Huang, L; Li, C; Liu, H; Shao, H; Wang, J; Wang, W; Wang, X; Wang, Z; Wu, W; Yang, Z; Zhang, Q; Zhang, R; Zhu, J; Zhu, Y, 2020) |
| "Dietary supplementation with CM fruits effectively prevents the development of diabetes mellitus, dyslipidemia and hepatic inflammation in alloxan-induced diabetes." | 3.80 | Biochemical and histopathological study of the anti-hyperglycemic and anti-hyperlipidemic effects of cornelian cherry (Cornus mas L.) in alloxan-induced diabetic rats. ( Asgary, S; Najafi, S; Rafieian-Kopaei, M; Sahebkar, A; Shamsi, F, 2014) |
| "This study investigated the role of K(ATP) channels in morphine-induced antinociception and hepatic oxidative stress in acute and inflammatory pain." | 3.79 | The involvement of K(ATP) channels in morphine-induced antinociception and hepatic oxidative stress in acute and inflammatory pain in rats. ( Afify, EA; Khedr, MM; Nasser, SA; Omar, AG, 2013) |
| "The present work evaluated the effects of the methanol extract of the bulbs of Dioscorea bulbifera in inflammatory and neuropathic models of pain and further investigated its possible mechanism of action." | 3.76 | Antinociceptive activities of the methanol extract of the bulbs of Dioscorea bulbifera L. var sativa in mice is dependent of NO-cGMP-ATP-sensitive-K(+) channel activation. ( Andrade, EL; Calixto, JB; Dutra, RC; Nguelefack, TB; Paszcuk, AF; Tapondjou, LA, 2010) |
| "The prevalence of nonalcoholic fatty liver disease (NAFLD) is much higher in patients with type II diabetes (T2D)." | 1.91 | Dimethyl fumarate-mediated Nrf2/ARE pathway activation and glibenclamide-mediated NLRP3 inflammasome cascade inhibition alleviate type II diabetes-associated fatty liver in rats by mitigating oxidative stress and inflammation. ( Dwivedi, DK; Jena, GB, 2023) |
| "Glyburide (Gly) could inhibit NLRP3 inflammasome, as well as could be treated with Type 2 diabetes as a common medication." | 1.62 | Glyburide attenuates B(a)p and LPS-induced inflammation-related lung tumorigenesis in mice. ( Feng, F; Gao, M; Huang, L; Li, M; Liu, H; Shang, P; Shao, H; Wang, W; Zhang, P; Zhang, Q, 2021) |
| "Chronic inflammation is known to occur in diabetes mellitus (DM) and contributes to atrial fibrosis, possible substrates for atrial fibrillation." | 1.43 | No Additional Effect of DPP-4 Inhibitor on Preventing Atrial Fibrosis in Streptozotocin-Induced Diabetic Rat as Compared With Sulfonylurea. ( Hayami, N; Iwasaki, YK; Murakawa, Y; Sekiguchi, A; Yamashita, T, 2016) |
| "Glyburide analogues inhibit ATP- but not hypothermia-induced IL-1beta secretion from human monocytes expressing familial cold-associated autoinflammatory syndrome-associated Cryopyrin mutations, thus suggesting that inhibition occurs upstream of Cryopyrin." | 1.35 | Glyburide inhibits the Cryopyrin/Nalp3 inflammasome. ( Deshayes, K; Dixit, VM; Fedorova, A; Hoffman, HM; Lamkanfi, M; Lee, WP; Misaghi, S; Mueller, JL; Vitari, AC, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 9 (21.95) | 29.6817 |
| 2010's | 19 (46.34) | 24.3611 |
| 2020's | 13 (31.71) | 2.80 |
| Authors | Studies |
|---|---|
| Saunders, MJ | 1 |
| Edwards, BS | 1 |
| Zhu, J | 2 |
| Sklar, LA | 1 |
| Graves, SW | 1 |
| Baldwin, AG | 1 |
| Brough, D | 1 |
| Freeman, S | 1 |
| Zhang, X | 1 |
| Xu, A | 1 |
| Lv, J | 1 |
| Zhang, Q | 3 |
| Ran, Y | 1 |
| Wei, C | 1 |
| Wu, J | 1 |
| Mahmoud, MF | 1 |
| Abdelaal, S | 1 |
| Mohammed, HO | 1 |
| El-Shazly, AM | 1 |
| Daoud, R | 1 |
| El Raey, MA | 1 |
| Sobeh, M | 1 |
| Jiang, M | 1 |
| Shang, Z | 1 |
| Zhang, T | 1 |
| Yin, X | 1 |
| Liang, X | 1 |
| Sun, H | 1 |
| Wu, Z | 1 |
| Jayachandran, M | 1 |
| Cheang, WS | 1 |
| Xu, B | 1 |
| Naderi, R | 2 |
| Pourheydar, B | 2 |
| Moslehi, A | 2 |
| Dwivedi, DK | 1 |
| Jena, GB | 1 |
| Ly, HT | 1 |
| Pham, KD | 1 |
| Le, PH | 1 |
| Do, THT | 1 |
| Nguyen, TTH | 1 |
| Le, VM | 1 |
| Esmaeili, MH | 1 |
| Enayati, M | 1 |
| Khabbaz Abkenar, F | 1 |
| Ebrahimian, F | 1 |
| Salari, AA | 1 |
| Shao, H | 2 |
| Huang, L | 2 |
| Duan, S | 1 |
| Gao, M | 2 |
| Chen, X | 1 |
| Zhu, Y | 1 |
| Wang, W | 2 |
| Yang, Z | 1 |
| Wang, X | 1 |
| Wang, Z | 2 |
| Ba, Y | 1 |
| Zhang, R | 2 |
| Li, C | 1 |
| Wang, J | 1 |
| Liu, H | 2 |
| Wu, W | 1 |
| Feng, F | 2 |
| Ferrero-Andrés, A | 1 |
| Panisello-Roselló, A | 1 |
| Roselló-Catafau, J | 1 |
| Folch-Puy, E | 1 |
| Li, M | 1 |
| Zhang, P | 1 |
| Shang, P | 1 |
| Sudaramoorthy, A | 1 |
| Shanmugam, G | 1 |
| Shanmugam, N | 1 |
| Cao, N | 1 |
| Wang, JJ | 1 |
| Wu, JM | 1 |
| Xu, WL | 1 |
| Wang, R | 1 |
| Chen, XD | 1 |
| Feng, YN | 1 |
| Cong, WW | 1 |
| Zhang, YY | 1 |
| Xiao, H | 1 |
| Dong, ED | 1 |
| Bansal, S | 1 |
| Chopra, K | 1 |
| Zhang, G | 2 |
| Lin, X | 1 |
| Zhang, S | 2 |
| Xiu, H | 1 |
| Pan, C | 1 |
| Cui, W | 2 |
| Peng, J | 1 |
| Deng, X | 1 |
| Huang, W | 1 |
| Yu, JH | 1 |
| Wang, JX | 1 |
| Wang, JP | 1 |
| Yang, SB | 1 |
| Liu, X | 1 |
| Wang, L | 1 |
| Zhang, Y | 2 |
| Zhou, XY | 1 |
| Yang, H | 1 |
| He, YZ | 1 |
| Xu, FY | 1 |
| Emfinger, CH | 1 |
| Yan, Z | 1 |
| Welscher, A | 1 |
| Hung, P | 1 |
| McAllister, W | 1 |
| Hruz, PW | 1 |
| Nichols, CG | 1 |
| Remedi, MS | 1 |
| Chen, H | 1 |
| Ding, Y | 1 |
| Chen, W | 1 |
| Feng, Y | 1 |
| Shi, G | 1 |
| Heyer, EJ | 1 |
| Mergeche, JL | 1 |
| Bruce, SS | 1 |
| Connolly, ES | 1 |
| Asgary, S | 1 |
| Rafieian-Kopaei, M | 1 |
| Shamsi, F | 1 |
| Najafi, S | 1 |
| Sahebkar, A | 1 |
| Cai, Z | 1 |
| Hu, X | 1 |
| Wang, Y | 1 |
| Li, N | 1 |
| Chen, Z | 1 |
| Honda, H | 1 |
| Nagai, Y | 1 |
| Matsunaga, T | 1 |
| Okamoto, N | 1 |
| Watanabe, Y | 1 |
| Tsuneyama, K | 1 |
| Hayashi, H | 1 |
| Fujii, I | 1 |
| Ikutani, M | 1 |
| Hirai, Y | 1 |
| Muraguchi, A | 1 |
| Takatsu, K | 1 |
| Hayami, N | 1 |
| Sekiguchi, A | 1 |
| Iwasaki, YK | 1 |
| Murakawa, Y | 1 |
| Yamashita, T | 1 |
| Oridupa, OA | 1 |
| Folasire, OF | 1 |
| Owolabi, AJ | 1 |
| Simard, JM | 1 |
| Geng, Z | 1 |
| Woo, SK | 1 |
| Ivanova, S | 1 |
| Tosun, C | 1 |
| Melnichenko, L | 1 |
| Gerzanich, V | 1 |
| González-Rodríguez, S | 1 |
| Hidalgo, A | 1 |
| Baamonde, A | 1 |
| Menéndez, L | 1 |
| Lamkanfi, M | 1 |
| Mueller, JL | 1 |
| Vitari, AC | 1 |
| Misaghi, S | 1 |
| Fedorova, A | 1 |
| Deshayes, K | 1 |
| Lee, WP | 1 |
| Hoffman, HM | 1 |
| Dixit, VM | 1 |
| Nguelefack, TB | 1 |
| Dutra, RC | 1 |
| Paszcuk, AF | 1 |
| Andrade, EL | 1 |
| Tapondjou, LA | 1 |
| Calixto, JB | 1 |
| Vuletic, S | 1 |
| Dong, W | 1 |
| Wolfbauer, G | 1 |
| Tang, C | 1 |
| Albers, JJ | 1 |
| Mizokami, SS | 1 |
| Arakawa, NS | 1 |
| Ambrosio, SR | 1 |
| Zarpelon, AC | 1 |
| Casagrande, R | 1 |
| Cunha, TM | 1 |
| Ferreira, SH | 1 |
| Cunha, FQ | 1 |
| Verri, WA | 1 |
| Afify, EA | 1 |
| Khedr, MM | 1 |
| Omar, AG | 1 |
| Nasser, SA | 1 |
| Ling, MY | 1 |
| Ma, ZY | 1 |
| Wang, YY | 1 |
| Qi, J | 1 |
| Liu, L | 1 |
| Li, L | 1 |
| Reyes-García, G | 2 |
| Castillo-Henkel, C | 1 |
| Medina-Santillán, R | 2 |
| Terán-Rosales, F | 2 |
| Granados-Soto, V | 2 |
| Rocha-González, HI | 1 |
| Rodríguez-Silverio, J | 1 |
| Flores-Murrieta, FJ | 1 |
| Esposito, K | 1 |
| Giugliano, D | 1 |
| Nappo, F | 1 |
| Marfella, R | 1 |
| Zager, RA | 1 |
| Johnson, AC | 1 |
| Lund, S | 1 |
| Hanson, SY | 1 |
| Abrass, CK | 1 |
| Yin, WH | 1 |
| Jen, HL | 1 |
| Chen, JW | 1 |
| Lin, SJ | 1 |
| Young, MS | 1 |
| Räkel, A | 1 |
| Renier, G | 1 |
| Roussin, A | 1 |
| Buithieu, J | 1 |
| Mamputu, JC | 1 |
| Serri, O | 1 |
| Kelly, AS | 1 |
| Thelen, AM | 1 |
| Kaiser, DR | 1 |
| Gonzalez-Campoy, JM | 1 |
| Bank, AJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Augmentation of Cerebral Blood Flow on Neuropsychometric Performance After Carotid Endarterectomy in Type II Diabetic Patients[NCT00597545] | 10 participants (Actual) | Interventional | 2007-03-31 | Terminated (stopped due to Half of DM patients had EEG changes and therefore were excluded.) | |||
| Neurologic and Neuropsychometric Outcome in Patients Undergoing Carotid Endarterectomy[NCT00597883] | 585 participants (Actual) | Observational | 2003-03-31 | Completed | |||
| FLAT-SUGAR: FLuctuATion Reduction With inSULin and Glp-1 Added togetheR[NCT01524705] | Phase 4 | 102 participants (Actual) | Interventional | 2012-08-31 | Completed | ||
| Variability of Glucose Assessed in a Randomized Trial Comparing the Initiation of A Treatment Approach With Biosimilar Basal Insulin Analog Or a Titratable iGlarLixi combinatioN in Type 2 Diabetes Among South Asian Subjects (VARIATION 2 SA Trial)[NCT03819790] | Phase 4 | 119 participants (Actual) | Interventional | 2018-10-02 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Battery of neuropsychometric tests to evaluate a variety of cognitive functions. (NCT00597545)
Timeframe: Post-operatively at 1 day
| Intervention | participants (Number) |
|---|---|
| Conventional Shunt | 1 |
| Prophylactic Shunt | 2 |
The change in the coefficient of variation (CV) of continuous glucose readings, as assessed by Continuous Glucose Monitoring (CGM) (NCT01524705)
Timeframe: At baseline, 6 months of intervention
| Intervention | percentage (Mean) |
|---|---|
| Insulin Glargine, Metformin, Exenatide | -2.43 |
| Insulin Glargine, Metformin, Prandial Insulin | 0.44 |
% of glycosylated hemoglobin in whole blood at 26 weeks (NCT01524705)
Timeframe: Baseline vs 26 weeks
| Intervention | % of HbA1C (Mean) |
|---|---|
| Insulin Glargine, Metformin, Exenatide | 7.1 |
| Insulin Glargine, Metformin, Prandial Insulin | 7.2 |
Severe hypoglycemia-documented glucose <50mg/dl (participant journal), and hypoglycemic attacks requiring hospitalization, or treatment by emergency personnel. (NCT01524705)
Timeframe: 26 weeks
| Intervention | Participants (Count of Participants) |
|---|---|
| Insulin Glargine, Metformin, Exenatide | 0 |
| Insulin Glargine, Metformin, Prandial Insulin | 0 |
Weight in kg at 26 weeks minus weight at baseline. (NCT01524705)
Timeframe: Baseline vs 26 weeks
| Intervention | kg (Mean) |
|---|---|
| Insulin Glargine, Metformin, Exenatide | -4.8 |
| Insulin Glargine, Metformin, Prandial Insulin | 0.7 |
4 reviews available for glyburide and Innate Inflammatory Response
| Article | Year |
|---|---|
Inhibiting the Inflammasome: A Chemical Perspective.
Topics: Animals; Humans; Inflammasomes; Inflammation; Molecular Conformation; Small Molecule Libraries; Stru | 2016 |
Development of small molecule inhibitors targeting NLRP3 inflammasome pathway for inflammatory diseases.
Topics: Humans; Inflammasomes; Inflammation; Molecular Structure; NLR Family, Pyrin Domain-Containing 3 Prot | 2020 |
NLRP3 Inflammasome-Mediated Inflammation in Acute Pancreatitis.
Topics: Animals; Anti-Inflammatory Agents; Gene Expression Regulation; Glyburide; Humans; Indomethacin; Infl | 2020 |
A Protective Role of Glibenclamide in Inflammation-Associated Injury.
Topics: Animals; Anti-Inflammatory Agents; Diabetes Mellitus, Type 2; Glyburide; Inflammation; Interleukin-1 | 2017 |
4 trials available for glyburide and Innate Inflammatory Response
| Article | Year |
|---|---|
Regression of carotid atherosclerosis by control of postprandial hyperglycemia in type 2 diabetes mellitus.
Topics: Adult; Aged; Biomarkers; Blood Glucose; Carbamates; Carotid Artery Diseases; Cross-Sectional Studies | 2004 |
Regression of carotid atherosclerosis by control of postprandial hyperglycemia in type 2 diabetes mellitus.
Topics: Adult; Aged; Biomarkers; Blood Glucose; Carbamates; Carotid Artery Diseases; Cross-Sectional Studies | 2004 |
Regression of carotid atherosclerosis by control of postprandial hyperglycemia in type 2 diabetes mellitus.
Topics: Adult; Aged; Biomarkers; Blood Glucose; Carbamates; Carotid Artery Diseases; Cross-Sectional Studies | 2004 |
Regression of carotid atherosclerosis by control of postprandial hyperglycemia in type 2 diabetes mellitus.
Topics: Adult; Aged; Biomarkers; Blood Glucose; Carbamates; Carotid Artery Diseases; Cross-Sectional Studies | 2004 |
Differential effects of peroxisome proliferator-activated receptor ligands and sulfonylurea plus statin treatment on plasma concentrations of adipokines in type 2 diabetes with dyslipidemia.
Topics: Adiponectin; Aged; Blood Glucose; Body Mass Index; Cohort Studies; Cytokines; Diabetes Mellitus, Typ | 2006 |
Beneficial effects of gliclazide modified release compared with glibenclamide on endothelial activation and low-grade inflammation in patients with type 2 diabetes.
Topics: Adult; Aged; Diabetes Mellitus, Type 2; Double-Blind Method; Endothelium, Vascular; Female; Gliclazi | 2007 |
Rosiglitazone improves endothelial function and inflammation but not asymmetric dimethylarginine or oxidative stress in patients with type 2 diabetes mellitus.
Topics: Adult; Aged; Arginine; Biomarkers; Blood Glucose; Blood Pressure; Brachial Artery; C-Reactive Protei | 2007 |
33 other studies available for glyburide and Innate Inflammatory Response
| Article | Year |
|---|---|
Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
Topics: Animals; Biotinylation; Flow Cytometry; Fluorescence Resonance Energy Transfer; Green Fluorescent Pr | 2010 |
Syzygium jambos extract mitigates pancreatic oxidative stress, inflammation and apoptosis and modulates hepatic IRS-2/AKT/GLUT4 signaling pathway in streptozotocin-induced diabetic rats.
Topics: Animals; Apoptosis; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Glucose Trans | 2021 |
Study on the role of pyroptosis in bone resorption induced by occlusal trauma with or without periodontitis.
Topics: Alveolar Bone Loss; Animals; Bone Resorption; Dental Occlusion, Traumatic; Glyburide; Inflammation; | 2022 |
Black Truffle Extract Exerts Antidiabetic Effects through Inhibition of Inflammation and Lipid Metabolism Regulation.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Ascomycota; Biological Products; Case-Contr | 2022 |
Tropisetron improved testicular inflammation in the streptozotocin-induced diabetic rats: The role of toll-like receptor 4 (TLR4) and mir146a.
Topics: Animals; Diabetes Complications; Diabetes Mellitus, Experimental; Glyburide; Inflammation; Male; NF- | 2023 |
Tropisetron improved testicular inflammation in the streptozotocin-induced diabetic rats: The role of toll-like receptor 4 (TLR4) and mir146a.
Topics: Animals; Diabetes Complications; Diabetes Mellitus, Experimental; Glyburide; Inflammation; Male; NF- | 2023 |
Tropisetron improved testicular inflammation in the streptozotocin-induced diabetic rats: The role of toll-like receptor 4 (TLR4) and mir146a.
Topics: Animals; Diabetes Complications; Diabetes Mellitus, Experimental; Glyburide; Inflammation; Male; NF- | 2023 |
Tropisetron improved testicular inflammation in the streptozotocin-induced diabetic rats: The role of toll-like receptor 4 (TLR4) and mir146a.
Topics: Animals; Diabetes Complications; Diabetes Mellitus, Experimental; Glyburide; Inflammation; Male; NF- | 2023 |
Dimethyl fumarate-mediated Nrf2/ARE pathway activation and glibenclamide-mediated NLRP3 inflammasome cascade inhibition alleviate type II diabetes-associated fatty liver in rats by mitigating oxidative stress and inflammation.
Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dimethyl Fumarate | 2023 |
Pharmacological properties of Ensete glaucum seed extract: Novel insights for antidiabetic effects via modulation of oxidative stress, inflammation, apoptosis and MAPK signaling pathways.
Topics: alpha-Glucosidases; Animals; Apoptosis; bcl-2-Associated X Protein; Diabetes Mellitus, Experimental; | 2024 |
Glibenclamide mitigates cognitive impairment and hippocampal neuroinflammation in rats with type 2 diabetes and sporadic Alzheimer-like disease.
Topics: Alzheimer Disease; Animals; Cognitive Dysfunction; Diabetes Complications; Diabetes Mellitus, Type 2 | 2020 |
Glyburide attenuates ozone-induced pulmonary inflammation and injury by blocking the NLRP3 inflammasome.
Topics: Acute Lung Injury; Air Pollutants; Animals; Bronchoalveolar Lavage Fluid; Caspase 1; Glyburide; Infl | 2020 |
Glyburide attenuates B(a)p and LPS-induced inflammation-related lung tumorigenesis in mice.
Topics: Animals; Benzo(a)pyrene; Carcinogenesis; Diabetes Mellitus, Type 2; Glyburide; Inflammasomes; Inflam | 2021 |
Inhibitory effect of Salvia coccinea on inflammatory responses through NF-κB signaling pathways in THP-1 cells and acute rat diabetes mellitus.
Topics: Active Transport, Cell Nucleus; Administration, Oral; Animals; Antioxidants; Blood Glucose; Catalase | 2021 |
Glibenclamide alleviates β adrenergic receptor activation-induced cardiac inflammation.
Topics: Animals; Arrhythmias, Cardiac; Glyburide; Inflammasomes; Inflammation; Isoproterenol; Male; Mice; Mi | 2022 |
Selective ER-α agonist alleviates vascular endothelial dysfunction in ovariectomized type 2 diabetic rats.
Topics: Acetylcholine; Animals; Aorta; Biomarkers; Blood Glucose; Body Weight; Diabetes Mellitus, Experiment | 2018 |
Irisin protects against neuronal injury induced by oxygen-glucose deprivation in part depends on the inhibition of ROS-NLRP3 inflammatory signaling pathway.
Topics: Animals; Brain Ischemia; Fibronectins; Glucose; Glyburide; HeLa Cells; Humans; Inflammation; Neurons | 2017 |
Contribution of systemic inflammation to permanence of K
Topics: Animals; Blood Glucose; Cytokines; Diabetes Mellitus; Glucagon; Glucagon-Like Peptide 1; Glyburide; | 2018 |
Glibenclamide alleviates inflammation in oleic acid model of acute lung injury through NLRP3 inflammasome signaling pathway.
Topics: Acute Lung Injury; Animals; Disease Models, Animal; Glyburide; Inflammasomes; Inflammation; Male; NL | 2019 |
Inflammation and cognitive dysfunction in type 2 diabetic carotid endarterectomy patients.
Topics: Aged; Cognition Disorders; Diabetes Mellitus, Type 2; Endarterectomy, Carotid; Glyburide; Humans; Hy | 2013 |
Inflammation and cognitive dysfunction in type 2 diabetic carotid endarterectomy patients.
Topics: Aged; Cognition Disorders; Diabetes Mellitus, Type 2; Endarterectomy, Carotid; Glyburide; Humans; Hy | 2013 |
Inflammation and cognitive dysfunction in type 2 diabetic carotid endarterectomy patients.
Topics: Aged; Cognition Disorders; Diabetes Mellitus, Type 2; Endarterectomy, Carotid; Glyburide; Humans; Hy | 2013 |
Inflammation and cognitive dysfunction in type 2 diabetic carotid endarterectomy patients.
Topics: Aged; Cognition Disorders; Diabetes Mellitus, Type 2; Endarterectomy, Carotid; Glyburide; Humans; Hy | 2013 |
Biochemical and histopathological study of the anti-hyperglycemic and anti-hyperlipidemic effects of cornelian cherry (Cornus mas L.) in alloxan-induced diabetic rats.
Topics: Alkaline Phosphatase; Alloxan; Animals; Anthocyanins; Blood Glucose; Chemical and Drug Induced Liver | 2014 |
The antidiabetic agent glibenclamide protects airway hyperresponsiveness and inflammation in mice.
Topics: Animals; Bronchial Hyperreactivity; Cells, Cultured; Chickens; Cytokines; Glyburide; Hypoglycemic Ag | 2015 |
Isoliquiritigenin is a potent inhibitor of NLRP3 inflammasome activation and diet-induced adipose tissue inflammation.
Topics: Adipose Tissue, White; Animals; Anti-Inflammatory Agents; Carrier Proteins; Cell Line, Tumor; Chalco | 2014 |
No Additional Effect of DPP-4 Inhibitor on Preventing Atrial Fibrosis in Streptozotocin-Induced Diabetic Rat as Compared With Sulfonylurea.
Topics: Adamantane; Animals; Anti-Inflammatory Agents; Atrial Fibrillation; Diabetes Mellitus, Experimental; | 2016 |
Evaluation of the sub-chronic toxicity profile of the corm of Xanthosoma sagittifolium on hematology and biochemistry of alloxan-induced diabetic Wistar rats.
Topics: Animals; Blood Glucose; Cholesterol, HDL; Cholesterol, LDL; Diabetes Mellitus, Experimental; Dyslipi | 2017 |
Glibenclamide reduces inflammation, vasogenic edema, and caspase-3 activation after subarachnoid hemorrhage.
Topics: Animals; ATP-Binding Cassette Transporters; Blood-Brain Barrier; Brain Edema; Carotid Artery Injurie | 2009 |
Spinal and peripheral mechanisms involved in the enhancement of morphine analgesia in acutely inflamed mice.
Topics: Acute Disease; Analgesia; Animals; Carrageenan; Glyburide; Inflammation; Injections, Spinal; Mice; M | 2010 |
Glyburide inhibits the Cryopyrin/Nalp3 inflammasome.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Carrier Proteins; Caspase 1; Cells, Cult | 2009 |
Antinociceptive activities of the methanol extract of the bulbs of Dioscorea bulbifera L. var sativa in mice is dependent of NO-cGMP-ATP-sensitive-K(+) channel activation.
Topics: Animals; Cyclic GMP; Female; Freund's Adjuvant; Glyburide; Hyperalgesia; Inflammation; KATP Channels | 2010 |
PLTP regulates STAT3 and NFκB in differentiated THP1 cells and human monocyte-derived macrophages.
Topics: ATP Binding Cassette Transporter 1; ATP-Binding Cassette Transporters; Biological Transport; Cell Di | 2011 |
Kaurenoic acid from Sphagneticola trilobata Inhibits Inflammatory Pain: effect on cytokine production and activation of the NO-cyclic GMP-protein kinase G-ATP-sensitive potassium channel signaling pathway.
Topics: Acetic Acid; Administration, Oral; Animals; Asteraceae; Carbazoles; Cyclic GMP-Dependent Protein Kin | 2012 |
The involvement of K(ATP) channels in morphine-induced antinociception and hepatic oxidative stress in acute and inflammatory pain in rats.
Topics: Acute Pain; Analgesics, Opioid; Animals; Chemical and Drug Induced Liver Injury; Diazoxide; Disease | 2013 |
Up-regulated ATP-sensitive potassium channels play a role in increased inflammation and plaque vulnerability in macrophages.
Topics: Animals; Atherosclerosis; Cell Line; Glyburide; Inflammation; KATP Channels; Macrophages; Mice; Pina | 2013 |
Mechanisms of analgesic action of B vitamins in formalin-induced inflammatory pain.
Topics: Analgesics; Animals; Behavior, Animal; Enzyme Inhibitors; Female; Formaldehyde; Glyburide; Inflammat | 2002 |
Riboflavin reduces hyperalgesia and inflammation but not tactile allodynia in the rat.
Topics: Analgesics; Animals; Carrageenan; Enzyme Inhibitors; Female; Glyburide; Hyperalgesia; Inflammation; | 2004 |
Levosimendan protects against experimental endotoxemic acute renal failure.
Topics: Acute Kidney Injury; Adenosine Triphosphate; Animals; Anti-Inflammatory Agents; Cardiotonic Agents; | 2006 |