glyburide has been researched along with Injury, Myocardial Reperfusion in 112 studies
Glyburide: An antidiabetic sulfonylurea derivative with actions like those of chlorpropamide
glyburide : An N-sulfonylurea that is acetohexamide in which the acetyl group is replaced by a 2-(5-chloro-2-methoxybenzamido)ethyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effect of glibenclamide and glimepiride, two orally active antidiabetic sulphonylurea derivatives, was investigated on the development of reperfusion-induced arrhythmias and it was compared to their blood glucose lowering action." | 7.70 | Comparison of the efficacy of glibenclamide and glimepiride in reperfusion-induced arrhythmias in rats. ( Baczkó, I; Bozdogan, O; El-Reyani, NE; Leprán, I; Papp, JG, 1999) |
| "Hydrogen sulfide (H2S) is a gaseous mediator, produced by the metabolic pathways that regulate tissue concentrations of sulfur-containing amino acids." | 5.33 | Exogenous hydrogen sulfide (H2S) protects against regional myocardial ischemia-reperfusion injury--Evidence for a role of K ATP channels. ( Baxter, GF; Johansen, D; Ytrehus, K, 2006) |
| "During reperfusion of ischemic myocardium, a burst of hydroxyl radicals (OH) induces contractile dysfunction ("myocardial stunning"), and OH in the plasma of patients after myocardial infarction predict the development of heart failure." | 3.75 | Endogenous activation of mitochondrial KATP channels protects human failing myocardium from hydroxyl radical-induced stunning. ( Böhm, M; Dabew, ER; Hohl, M; Maack, C; Schäfers, HJ, 2009) |
| "The effect of glibenclamide and glimepiride, two orally active antidiabetic sulphonylurea derivatives, was investigated on the development of reperfusion-induced arrhythmias and it was compared to their blood glucose lowering action." | 3.70 | Comparison of the efficacy of glibenclamide and glimepiride in reperfusion-induced arrhythmias in rats. ( Baczkó, I; Bozdogan, O; El-Reyani, NE; Leprán, I; Papp, JG, 1999) |
| " We have thus studied the effects of glibenclamide and cromakalim, KATP channel blocker and opener respectively, on membrane lipid injury and arrhythmias, in a model of ischemic-reperfused guinea-pig myocardium." | 3.70 | KATP channel modulators and myocardial damages induced by ischemia-reperfusion: membrane lipids injury and arrhythmias. ( Chesnay, F; Duval, D; Gérard, JL; Picard, S; Rouet, R, 1998) |
| " In order to investigate the role of KATP channel activation and repolarization dispersion on the 'border zone' arrhythmias induced by ischaemia-reperfusion, the effects of glibenclamide and bimakalim, agents modifying action potential (AP) duration, were studied in an in vitro model of myocardial 'border zone'." | 3.70 | KATP channels and 'border zone' arrhythmias: role of the repolarization dispersion between normal and ischaemic ventricular regions. ( Criniti, A; Ducouret, P; Flais, F; Gérard, JL; Monti, F; Picard, S; Puddu, PE; Rouet, R, 1999) |
| "We have previously reported that cromakalim and U-89232 reduce infarct size in a rabbit model of myocardial ischemia." | 3.69 | Cardioprotection with U-89232 is not reversible with glibenclamide: evidence of a novel anti-ischemic agent derived from cromakalim. ( Moore, TL; Shebuski, RJ; Toombs, CF, 1994) |
| "We studied the effects of ATP-sensitive potassium channel (KATP) modulation on ischemic cardiac performance and reperfusion-induced ventricular fibrillation (VF), and assessed the contribution of KATP to the cardioprotective and anti-arrhythmic effect of the anti-hypertensive drug cicletanine." | 3.69 | KATP channel modulation in working rat hearts with coronary occlusion: effects of cromakalim, cicletanine, and glibenclamide. ( Droy-Lefaix, MT; Ferdinandy, P; Koltai, M; Szilvássy, Z; Tarrade, T, 1995) |
| "We investigated the effect of ATP-sensitive K+ channel (KATP) openers (pinacidil and cromakalim), and a KATP blocker (glibenclamide) on reperfusion-induced arrhythmias in pentobarbitone-anaesthetized rats." | 3.69 | KATP channel modulators increase survival rate during coronary occlusion-reperfusion in anaesthetized rats. ( Baczkó, I; Leprán, I; Papp, JG, 1997) |
| " Hearts were subjected to 15 min of hypoxia followed by reoxygenation in the presence and in the absence of 100 microns glyburide, an ATP-sensitive potassium channel blocker." | 3.68 | Influence of ATP-sensitive potassium channel blocker on hypoxia-induced damage of isolated guinea pig heart. ( Branz, AJ; McKean, TA, 1992) |
| "There were fewer malignant arrhythmias with PerC during reperfusion (P = 0." | 1.34 | Intermittent peripheral tissue ischemia during coronary ischemia reduces myocardial infarction through a KATP-dependent mechanism: first demonstration of remote ischemic perconditioning. ( Cheung, M; Dzavik, V; Kharbanda, RK; Konstantinov, IE; Kristiansen, SB; Li, J; Redington, AN; Schmidt, MR; Shimizu, M; Smerup, M; Sorensen, K; White, PA, 2007) |
| "Hydrogen sulfide (H2S) is a gaseous mediator, produced by the metabolic pathways that regulate tissue concentrations of sulfur-containing amino acids." | 1.33 | Exogenous hydrogen sulfide (H2S) protects against regional myocardial ischemia-reperfusion injury--Evidence for a role of K ATP channels. ( Baxter, GF; Johansen, D; Ytrehus, K, 2006) |
| "More importantly, the incidence of ventricular tachycardia in the STZ-GLIB group was significantly higher than that in the STZ-VEH group (93% vs 54%, P < 0." | 1.32 | Long-term treatment with glibenclamide increases susceptibility of streptozotocin-induced diabetic rat heart to reperfusion-induced ventricular tachycardia. ( Iwao, T; Ooie, T; Saikawa, T; Sakata, T; Takahashi, N; Yoshimatsu, H, 2003) |
| "Cardiac hypertrophy has been demonstrated to decreases the ATP-sensitive potassium channels (K(ATP)), the major protective mechanism following the energy depletion, a common condition seen during the reperfusion after open heart surgery." | 1.32 | Ischemic preconditioning prevents reperfusion heart injury in cardiac hypertrophy by activation of mitochondrial KATP channels. ( Maeda, H; Rajesh, KG; Sasaguri, S; Suzuki, R; Xing, Y, 2004) |
| "Sevoflurane was as effective as halothane in improving postcardioplegic functional performance." | 1.31 | Reduction of postischemic contractile dysfunction of the isolated rat heart by sevoflurane: comparison with halothane. ( Coetzee, JF; Genade, S; le Roux, PJ; Lochner, A, 2000) |
| "Pretreatment with diazoxide (100 microM), a selective mK(ATP) channel opener, for 5 min followed by 10 min washout before the 30-min ischemia and 2-h reperfusion significantly reduced infarct size (9 +/- 3 vs." | 1.31 | Dual roles of mitochondrial K(ATP) channels in diazoxide-mediated protection in isolated rabbit hearts. ( Cone, J; Liu, Y; Wang, S, 2001) |
| "Pretreatment with diazoxide (100 microM) with a 10-min washout period reduced %IS/LV to 7." | 1.31 | Critical timing of mitochondrial K(ATP) channel opening for enhancement of myocardial tolerance against infarction. ( Genda, S; Kuno, A; Matsumoto, T; Miki, T; Miura, T; Nozawa, Y; Shimamoto, K; Tanno, M; Tsuchida, A, 2001) |
| "Over a 1-h period of anoxia, 59% of Tr cells and 85% Sed cells expressed I(K(ATP))." | 1.31 | Exercise training alters an anoxia-induced, glibenclamide-sensitive current in rat ventricular cardiocytes. ( Jew, KN; Moore, RL, 2002) |
| "In untreated hearts, tachyarrhythmias occurred during the reperfusion, and less pronounced during the coronary occlusion itself." | 1.30 | Concerning the effect of the K+ channel blocking agent glibenclamide on ischaemic and reperfusion arrhythmias. ( Bernauer, W, 1997) |
| "The pinacidil DRC was shifted to the right by glibenclamide and L-NOARG and to the left by SIN-1 and adenosine." | 1.30 | Inhibitors of nitric oxide synthesis and ischemia/reperfusion attenuate coronary vasodilator response to pinacidil in isolated rat heart. ( Beresewicz, A; Maczewski, M, 1997) |
| "Cromakalim is a member of the new antihypertensive drug family possessing an action that involves an increased K efflux in vascular and cardiac muscle." | 1.29 | Potassium channel openers and blockers: do they possess proarrhythmic or antiarrhythmic activity in ischemic and reperfused rat hearts? ( Das, DK; Engelman, RM; Szerdahelyi, P; Tosaki, A, 1993) |
| "The incidence of ventricular tachycardia followed the same pattern." | 1.29 | Adenosine triphosphate-sensitive potassium channel blocking agent ameliorates, but the opening agent aggravates, ischemia/reperfusion-induced injury. Heart function studies in nonfibrillating isolated hearts. ( Hellegouarch, A; Tosaki, A, 1994) |
| "Isoflurane was discontinued at the onset of the final reperfusion period." | 1.29 | Mechanism of myocardial protection by isoflurane. Role of adenosine triphosphate-regulated potassium (KATP) channels. ( Gross, GJ; Hettrick, DA; Kersten, JR; Pagel, PS; Schmeling, TJ; Warltier, DC, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 56 (50.00) | 18.2507 |
| 2000's | 47 (41.96) | 29.6817 |
| 2010's | 9 (8.04) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kaya, ST | 1 |
| Bozdogan, O | 3 |
| Ozarslan, TO | 1 |
| Taskin, E | 1 |
| Eksioglu, D | 1 |
| Erim, F | 1 |
| Firat, T | 1 |
| Yasar, S | 1 |
| Maslov, LN | 4 |
| Lasukova, OV | 1 |
| Krylatov, AV | 3 |
| Khanush, L | 1 |
| Lishmanov, IuB | 1 |
| Alexandre, J | 1 |
| Puddu, PE | 2 |
| Simard, C | 1 |
| Hof, T | 1 |
| Sallé, L | 1 |
| Guinamard, R | 1 |
| Manrique, A | 1 |
| Rouet, R | 3 |
| Beygui, F | 1 |
| Milliez, P | 1 |
| Dudek, M | 1 |
| Knutelska, J | 1 |
| Bednarski, M | 1 |
| Nowiński, L | 1 |
| Zygmunt, M | 1 |
| Bilska-Wilkosz, A | 1 |
| Iciek, M | 1 |
| Otto, M | 1 |
| Żytka, I | 1 |
| Sapa, J | 1 |
| Włodek, L | 1 |
| Filipek, B | 1 |
| Bu, HM | 1 |
| Yang, CY | 1 |
| Wang, ML | 1 |
| Ma, HJ | 3 |
| Sun, H | 1 |
| Zhang, Y | 4 |
| Meng, LM | 1 |
| Guo, H | 1 |
| Kong, QQ | 1 |
| Zhao, JL | 1 |
| Yang, YJ | 1 |
| Pei, WD | 1 |
| Sun, YH | 1 |
| Zhai, M | 1 |
| Liu, YX | 2 |
| Gao, RL | 1 |
| Lishmanov, YB | 1 |
| Oeltgen, PR | 1 |
| Barzakh, EI | 2 |
| Govindaswami, M | 1 |
| Brown, SA | 1 |
| Bodiga, S | 1 |
| Zhang, R | 1 |
| Jacobs, DE | 1 |
| Larsen, BT | 1 |
| Tampo, A | 1 |
| Manthati, VL | 1 |
| Kwok, WM | 1 |
| Zeldin, DC | 1 |
| Falck, JR | 1 |
| Gutterman, DD | 1 |
| Jacobs, ER | 1 |
| Medhora, MM | 1 |
| Maack, C | 1 |
| Dabew, ER | 1 |
| Hohl, M | 1 |
| Schäfers, HJ | 1 |
| Böhm, M | 1 |
| Chernysheva, GA | 1 |
| Krieg, T | 1 |
| Solenkova, NV | 1 |
| Lishmanov, AY | 2 |
| Cybulnikov, SY | 1 |
| Ma, H | 1 |
| Huang, X | 1 |
| Li, Q | 1 |
| Guan, Y | 1 |
| Yuan, F | 1 |
| Lv, Y | 1 |
| Ren, Y | 1 |
| Sun, L | 1 |
| Wang, S | 2 |
| Wei, M | 1 |
| Jia, D | 1 |
| Kupriyanov, VV | 1 |
| Xiang, B | 1 |
| Sun, J | 1 |
| Jilkina, O | 1 |
| Shi, E | 1 |
| Jiang, X | 1 |
| Bai, H | 1 |
| Gu, T | 1 |
| Chang, Y | 1 |
| Wang, J | 1 |
| Takahashi, N | 3 |
| Ooie, T | 3 |
| Saikawa, T | 4 |
| Iwao, T | 1 |
| Yoshimatsu, H | 3 |
| Sakata, T | 2 |
| Lee, BH | 2 |
| Seo, HW | 2 |
| Yoo, SE | 3 |
| Ma, SG | 1 |
| Fu, RF | 1 |
| Feng, GQ | 1 |
| Wang, ZJ | 1 |
| Ma, XQ | 1 |
| Weng, SA | 1 |
| Tavackoli, S | 1 |
| Ashitkov, T | 1 |
| Hu, ZY | 1 |
| Motamedi, M | 1 |
| Uretsky, BF | 1 |
| Birnbaum, Y | 1 |
| Rajesh, KG | 1 |
| Sasaguri, S | 1 |
| Suzuki, R | 1 |
| Xing, Y | 1 |
| Maeda, H | 1 |
| Miura, T | 3 |
| Miki, T | 2 |
| Dong, JH | 1 |
| Zhao, J | 1 |
| Guo, SM | 1 |
| He, RR | 2 |
| Gori, T | 1 |
| Sicuro, S | 1 |
| Dragoni, S | 1 |
| Donati, G | 1 |
| Forconi, S | 1 |
| Parker, JD | 1 |
| García-Villalón, AL | 1 |
| Amezquita, YM | 1 |
| Monge, L | 1 |
| Fernández, N | 1 |
| Climent, B | 1 |
| Sánchez, A | 1 |
| Diéguez, G | 1 |
| Fujii, M | 1 |
| Chambers, DJ | 1 |
| Johansen, D | 1 |
| Ytrehus, K | 1 |
| Baxter, GF | 1 |
| Maruyama, I | 1 |
| Tomiyama, Y | 1 |
| Maruyama, K | 1 |
| Ojima, K | 1 |
| Kobayashi, K | 1 |
| Kobayashi, M | 1 |
| Yamazaki, Y | 1 |
| Kojima, M | 1 |
| Shibata, N | 1 |
| Obata, T | 1 |
| Taniguchi, Y | 2 |
| Shinohara, T | 2 |
| Nakagawa, M | 2 |
| Yonemochi, H | 1 |
| Hara, M | 2 |
| Schmidt, MR | 1 |
| Smerup, M | 1 |
| Konstantinov, IE | 1 |
| Shimizu, M | 1 |
| Li, J | 1 |
| Cheung, M | 1 |
| White, PA | 1 |
| Kristiansen, SB | 2 |
| Sorensen, K | 1 |
| Dzavik, V | 1 |
| Redington, AN | 1 |
| Kharbanda, RK | 1 |
| Strande, JL | 1 |
| Hsu, A | 1 |
| Su, J | 1 |
| Fu, X | 1 |
| Gross, GJ | 12 |
| Baker, JE | 1 |
| Donato, M | 1 |
| D'Annunzio, V | 1 |
| Berg, G | 1 |
| Gonzalez, G | 1 |
| Schreier, L | 1 |
| Morales, C | 1 |
| Wikinski, RL | 1 |
| Gelpi, RJ | 1 |
| Kohno, H | 1 |
| Yamanaka, K | 1 |
| Wakisaka, O | 1 |
| Murozono, Y | 1 |
| Torigoe, Y | 1 |
| Shimada, T | 1 |
| Hu, Y | 1 |
| Chen, X | 1 |
| Pan, TT | 2 |
| Neo, KL | 2 |
| Lee, SW | 1 |
| Khin, ES | 1 |
| Moore, PK | 1 |
| Bian, JS | 2 |
| Namekata, I | 1 |
| Yamaguchi, Y | 1 |
| Moriguchi, S | 1 |
| Yamazaki, S | 1 |
| Terasawa, A | 1 |
| Yamagishi, R | 1 |
| Aikawa, T | 1 |
| Saito, T | 1 |
| Kurashima, K | 1 |
| Seri, K | 1 |
| Imamura, Y | 1 |
| Akita, H | 1 |
| Shigenobu, K | 2 |
| Tanaka, H | 2 |
| Rossoni, G | 1 |
| Sparatore, A | 1 |
| Tazzari, V | 1 |
| Manfredi, B | 1 |
| Del Soldato, P | 1 |
| Berti, F | 1 |
| Lasukova, TV | 1 |
| Crawford, D | 1 |
| Wong, TM | 1 |
| Hu, LF | 1 |
| Yong, QC | 1 |
| Colantuono, G | 1 |
| Tiravanti, EA | 1 |
| Di Venosa, N | 1 |
| Cazzato, A | 1 |
| Rastaldo, R | 1 |
| Cagiano, R | 1 |
| D'Agostino, D | 1 |
| Federici, A | 1 |
| Fiore, T | 1 |
| Bazargan, M | 1 |
| Faghihi, M | 1 |
| Chitsaz, M | 1 |
| Løfgren, B | 1 |
| Støttrup, NB | 1 |
| Kimose, HH | 1 |
| Nielsen-Kudsk, JE | 1 |
| Bøtker, HE | 1 |
| Nielsen, TT | 1 |
| Mozaffari, MS | 1 |
| Schaffer, SW | 1 |
| Lee, SH | 1 |
| Yang, MK | 1 |
| Lim, JH | 1 |
| Yi, KY | 1 |
| Won, HS | 1 |
| Lee, CS | 1 |
| Choi, WS | 1 |
| Shin, HS | 2 |
| Ji, Y | 1 |
| Pang, QF | 1 |
| Xu, G | 1 |
| Wang, L | 1 |
| Wang, JK | 1 |
| Zeng, YM | 1 |
| Shigematsu, S | 1 |
| Sato, T | 1 |
| Abe, T | 1 |
| Arita, M | 1 |
| Ferdinandy, P | 2 |
| Szilvássy, Z | 2 |
| Koltai, M | 2 |
| Dux, L | 1 |
| Moritani, K | 1 |
| Miyazaki, T | 1 |
| Miyoshi, S | 1 |
| Asanagi, M | 1 |
| Zhao, LS | 1 |
| Mitamura, H | 1 |
| Ogawa, S | 1 |
| Li, YL | 1 |
| Yao, Z | 3 |
| D'Alonzo, AJ | 2 |
| Darbenzio, RB | 2 |
| Hess, TA | 1 |
| Sewter, JC | 1 |
| Sleph, PG | 2 |
| Grover, GJ | 6 |
| Toombs, CF | 3 |
| Moore, TL | 2 |
| Shebuski, RJ | 2 |
| Pieper, GM | 1 |
| Auchampach, JA | 5 |
| Bellemin-Baurreau, J | 1 |
| Poizot, A | 1 |
| Hicks, PE | 1 |
| Rochette, L | 1 |
| Armstrong, JM | 1 |
| Iwamoto, T | 1 |
| Urabe, K | 1 |
| Itoya, M | 1 |
| Shimamoto, K | 2 |
| Iimura, O | 1 |
| Tosaki, A | 3 |
| Szerdahelyi, P | 1 |
| Engelman, RM | 2 |
| Das, DK | 2 |
| Lu, H | 1 |
| Remeysen, P | 1 |
| De Clerck, F | 1 |
| Hellegouarch, A | 1 |
| McGee, DS | 1 |
| Johnston, WE | 1 |
| Vinten-Johansen, J | 1 |
| Fralix, TA | 1 |
| Steenbergen, C | 1 |
| London, RE | 1 |
| Murphy, E | 1 |
| Vegh, A | 1 |
| Papp, JG | 4 |
| Szekeres, L | 1 |
| Parratt, JR | 1 |
| Nakaya, H | 1 |
| Warltier, DC | 2 |
| Menasché, P | 1 |
| Kevelaitis, E | 1 |
| Mouas, C | 1 |
| Grousset, C | 1 |
| Piwnica, A | 1 |
| Bloch, G | 1 |
| Hide, EJ | 2 |
| Ney, P | 1 |
| Piper, J | 2 |
| Thiemermann, C | 2 |
| Vane, JR | 1 |
| Droy-Lefaix, MT | 1 |
| Tarrade, T | 1 |
| Sargent, CA | 2 |
| Wilde, MW | 1 |
| Dzwonczyk, S | 3 |
| Tuttle, JG | 1 |
| Murray, HN | 1 |
| Atwal, K | 1 |
| Nakagawa, C | 1 |
| Asayama, J | 1 |
| Tatsumi, T | 1 |
| Matoba, S | 1 |
| Kobara, M | 1 |
| Tanaka, T | 1 |
| Ohta, B | 1 |
| Kawahara, A | 1 |
| Tsuruyama, K | 1 |
| Katamura, M | 1 |
| Okazaki, K | 1 |
| Kersten, JR | 1 |
| Schmeling, TJ | 1 |
| Hettrick, DA | 1 |
| Pagel, PS | 1 |
| Rahman, F | 1 |
| Kato, A | 1 |
| Kawahara, K | 1 |
| Nakajima, T | 1 |
| Cleveland, JC | 1 |
| Meldrum, DR | 1 |
| Rowland, RT | 1 |
| Banerjee, A | 1 |
| Harken, AH | 1 |
| Gomoll, AW | 1 |
| Roth, RA | 1 |
| Swillo, RE | 1 |
| Baird, AJ | 1 |
| Sargent, CS | 1 |
| Behling, RW | 1 |
| Malone, HJ | 1 |
| Baczkó, I | 2 |
| Leprán, I | 3 |
| Bernauer, W | 1 |
| Maczewski, M | 1 |
| Beresewicz, A | 1 |
| Zhu, JL | 1 |
| Dorso, CR | 1 |
| Jung, YS | 1 |
| Moon, CH | 1 |
| Cho, TS | 1 |
| Elliott, GT | 1 |
| Mei, DA | 1 |
| Tracey, WR | 1 |
| Magee, W | 1 |
| Masamune, H | 1 |
| Oleynek, JJ | 1 |
| Hill, RJ | 1 |
| El-Reyani, NE | 1 |
| Picard, S | 2 |
| Duval, D | 1 |
| Chesnay, F | 1 |
| Gérard, JL | 2 |
| Fryer, RM | 1 |
| Hsu, AK | 1 |
| Eells, JT | 1 |
| Nagase, H | 1 |
| Tanonaka, K | 1 |
| Kajiwara, H | 1 |
| Kameda, H | 1 |
| Takasaki, A | 1 |
| Takeo, S | 1 |
| Du Toit, EF | 2 |
| Muller, CA | 1 |
| McCarthy, J | 1 |
| Opie, LH | 2 |
| Ducouret, P | 1 |
| Flais, F | 1 |
| Criniti, A | 1 |
| Monti, F | 1 |
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| Farhangkhgoee, P | 1 |
| Karmazyn, M | 1 |
| Lee, YM | 1 |
| Peng, YY | 1 |
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| Bouchard, JF | 2 |
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| Genda, S | 1 |
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| Moore, RL | 1 |
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| del Valle, HF | 1 |
| Crottogini, AJ | 1 |
| Cavero, I | 3 |
| Maruyama, M | 2 |
| Pasnani, JS | 1 |
| Ferrier, GR | 1 |
| McKean, TA | 1 |
| Branz, AJ | 1 |
| Cole, WC | 1 |
| McPherson, CD | 1 |
| Sontag, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Remote Preconditioning in Primary Percutaneous Intervention of Acute ST Elevation Myocardial Infarction[NCT00435266] | Phase 2/Phase 3 | 250 participants (Anticipated) | Interventional | 2007-02-28 | Completed | ||
| Remote Ischemic Preconditioning in Head and Neck Cancer Reconstruction - A Randomized Controlled Trial[NCT02548377] | 60 participants (Actual) | Interventional | 2015-09-29 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for glyburide and Injury, Myocardial Reperfusion
| Article | Year |
|---|---|
ATP-sensitive K+ channel openers: old drugs with new clinical benefits for the heart.
Topics: Adenosine Triphosphate; Animals; Coronary Circulation; Coronary Disease; Diazoxide; Glyburide; Human | 2003 |
[Role of ATP sensitive K(+)-channels in cardiovascular system].
Topics: Adenosine Triphosphate; Animals; Glyburide; Myocardial Reperfusion Injury; Potassium Channels | 1994 |
[Potential role of ATP-sensitive K+ channels in ischemia- and reperfusion-induced arrhythmias].
Topics: Action Potentials; Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Benzopyrans; Cromakalim; G | 1993 |
2 trials available for glyburide and Injury, Myocardial Reperfusion
| Article | Year |
|---|---|
Sildenafil prevents endothelial dysfunction induced by ischemia and reperfusion via opening of adenosine triphosphate-sensitive potassium channels: a human in vivo study.
Topics: Adult; Cross-Over Studies; Double-Blind Method; Endothelium, Vascular; Glyburide; Humans; Male; Midd | 2005 |
Adenosine preconditioning of human myocardium is dependent upon the ATP-sensitive K+ channel.
Topics: Adenosine; Adenosine Triphosphate; Analysis of Variance; Cardiovascular Agents; Computer Simulation; | 1997 |
107 other studies available for glyburide and Injury, Myocardial Reperfusion
| Article | Year |
|---|---|
The protection of resveratrol and its combination with glibenclamide, but not berberine on the diabetic hearts against reperfusion-induced arrhythmias: the role of myocardial K
Topics: Animals; Arrhythmias, Cardiac; Berberine; Diabetes Mellitus, Experimental; Dose-Response Relationshi | 2019 |
[Mediated role of NO-syntase, protein kinase C and KATP-channels in realization of cardioprotective impact of cannabinoid HU-210].
Topics: Animals; Benzophenanthridines; Cannabinoid Receptor Agonists; Cardiotonic Agents; Dronabinol; Glybur | 2012 |
Proarrhythmic effects of aldosterone during myocardial ischemia-reperfusion: implication of the sarcolemmal-KATP channels.
Topics: Action Potentials; Aldosterone; Animals; Benzopyrans; Dihydropyridines; Disease Models, Animal; Fema | 2014 |
Alpha lipoic acid protects the heart against myocardial post ischemia-reperfusion arrhythmias via KATP channel activation in isolated rat hearts.
Topics: Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Animals; Antioxidants; Arrhythmias, C | 2014 |
K(ATP) channels and MPTP are involved in the cardioprotection bestowed by chronic intermittent hypobaric hypoxia in the developing rat.
Topics: Animals; Atmospheric Pressure; Atractyloside; Cardiotonic Agents; Cyclosporine; Decanoic Acids; Diaz | 2015 |
The cardioprotective effect of naringenin against ischemia-reperfusion injury through activation of ATP-sensitive potassium channel in rat.
Topics: Animals; Cardiotonic Agents; Decanoic Acids; Flavanones; Glyburide; Heart; Hydroxy Acids; KATP Chann | 2016 |
Carvedilol reduces myocardial no-reflow by decreasing endothelin-1 via activation of the ATP-sensitive K+ channel.
Topics: Animals; Antihypertensive Agents; Carbazoles; Carvedilol; Disease Models, Animal; Endothelin-1; Glyb | 2008 |
Activation of peripheral delta2 opioid receptors increases cardiac tolerance to ischemia/reperfusion injury Involvement of protein kinase C, NO-synthase, KATP channels and the autonomic nervous system.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Autonomic Nervous System; Benzophenanthridine | 2009 |
Protective actions of epoxyeicosatrienoic acid: dual targeting of cardiovascular PI3K and KATP channels.
Topics: 8,11,14-Eicosatrienoic Acid; Androstadienes; Animals; Animals, Newborn; Caspase 3; Cells, Cultured; | 2009 |
Endogenous activation of mitochondrial KATP channels protects human failing myocardium from hydroxyl radical-induced stunning.
Topics: Atrial Function, Left; Cardiomyopathy, Dilated; Diabetes Complications; Female; Gene Expression Regu | 2009 |
Opioid peptide deltorphin II simulates the cardioprotective effect of ischemic preconditioning: role of δ₂-opioid receptors, protein kinase C, and K(ATP) channels.
Topics: Animals; Benzophenanthridines; Benzylidene Compounds; Decanoic Acids; Glyburide; Hydroxy Acids; Isch | 2010 |
ATP-dependent potassium channels and mitochondrial permeability transition pores play roles in the cardioprotection of theaflavin in young rat.
Topics: Animals; Atractyloside; Biflavonoids; Cardiotonic Agents; Catechin; Decanoic Acids; Glyburide; Heart | 2011 |
Protective effect of Na(+)/Ca (2+) exchange blocker KB-R7943 on myocardial ischemia-reperfusion injury in hypercholesterolemic rats.
Topics: Animals; Anti-Arrhythmia Agents; Apoptosis; Diet, High-Fat; Disease Models, Animal; Glyburide; Hemod | 2013 |
The effects of drugs modulating K(+) transport on Rb(+) uptake and distribution in pig hearts following regional ischemia: (87)Rb MRI study.
Topics: Animals; Bumetanide; Glyburide; In Vitro Techniques; Magnetic Resonance Imaging; Myocardial Infarcti | 2002 |
Cardioprotective effects of morphine on rat heart suffering from ischemia and reperfusion.
Topics: Animals; Cardiotonic Agents; Glyburide; Heart; In Vitro Techniques; Ischemic Preconditioning, Myocar | 2003 |
Long-term treatment with glibenclamide increases susceptibility of streptozotocin-induced diabetic rat heart to reperfusion-induced ventricular tachycardia.
Topics: Animals; Arrhythmias, Cardiac; Blood Glucose; Blood Pressure; Body Weight; Creatine Kinase; Diabetes | 2003 |
Cardioprotective effects of (2S,3R,4S)-N'-benzyl-N"-cyano-N-(3,4-dihydro-2-dimethoxymethyl-3-hydroxy-2-methyl-6-nitro-2H-benzopyran-4-yl)-guanidine (KR-31372) in rats and dogs.
Topics: Animals; Benzopyrans; Cardiovascular Agents; Coronary Circulation; Coronary Disease; Dogs; Dose-Resp | 2004 |
Effect of G(alphaq/11) protein and ATP-sensitive potassium channels on prostaglandin E(1) preconditioning in rat hearts.
Topics: Adenosine Triphosphate; Alprostadil; Animals; Glyburide; GTP-Binding Protein alpha Subunits, Gq-G11; | 2004 |
Simvastatin-induced myocardial protection against ischemia-reperfusion injury is mediated by activation of ATP-sensitive K+ channels.
Topics: Animals; Anti-Arrhythmia Agents; ATP-Binding Cassette Transporters; Collateral Circulation; Disease | 2004 |
Ischemic preconditioning prevents reperfusion heart injury in cardiac hypertrophy by activation of mitochondrial KATP channels.
Topics: Adenosine Triphosphate; Animals; Cardiomegaly; Decanoic Acids; Disease Models, Animal; Glyburide; He | 2004 |
High-frequency electrical stimulation of femoral nerve reduces infarct size following myocardial ischemia-reperfusion in rats.
Topics: Animals; Electric Stimulation; Femoral Nerve; Glyburide; Male; Myocardial Infarction; Myocardial Rep | 2004 |
Mechanisms of the protective effects of urocortin on coronary endothelial function during ischemia-reperfusion in rat isolated hearts.
Topics: Acetylcholine; Alkaloids; Animals; Benzophenanthridines; Cardiovascular Agents; Corticotropin-Releas | 2005 |
Myocardial protection with intermittent cross-clamp fibrillation: does preconditioning play a role?
Topics: Animals; Constriction; Coronary Artery Bypass; Creatine Kinase; Glyburide; Ischemic Preconditioning, | 2005 |
Exogenous hydrogen sulfide (H2S) protects against regional myocardial ischemia-reperfusion injury--Evidence for a role of K ATP channels.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Cardiac Output; Decanoic Acids; Glyburide; | 2006 |
Effects of mitiglinide and sulfonylureas in isolated canine coronary arteries and perfused rat hearts.
Topics: Animals; Coronary Circulation; Coronary Vessels; Cromakalim; Dogs; Dose-Response Relationship, Drug; | 2006 |
Blocking cardiac ATP-sensitive K+ channels reduces hydroxyl radicals caused by potassium chloride-induced depolarization in the rat myocardium.
Topics: Adenosine Triphosphate; Animals; Decanoic Acids; Glyburide; Hydroxy Acids; Hydroxybenzoates; Hydroxy | 2006 |
Pioglitazone but not glibenclamide improves cardiac expression of heat shock protein 72 and tolerance against ischemia/reperfusion injury in the heredity insulin-resistant rat.
Topics: Animals; Blotting, Western; Diabetes Mellitus, Type 2; Fever; Glucose Tolerance Test; Glyburide; HSP | 2006 |
Intermittent peripheral tissue ischemia during coronary ischemia reduces myocardial infarction through a KATP-dependent mechanism: first demonstration of remote ischemic perconditioning.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Body Temperature; Ele | 2007 |
Intermittent peripheral tissue ischemia during coronary ischemia reduces myocardial infarction through a KATP-dependent mechanism: first demonstration of remote ischemic perconditioning.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Body Temperature; Ele | 2007 |
Intermittent peripheral tissue ischemia during coronary ischemia reduces myocardial infarction through a KATP-dependent mechanism: first demonstration of remote ischemic perconditioning.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Body Temperature; Ele | 2007 |
Intermittent peripheral tissue ischemia during coronary ischemia reduces myocardial infarction through a KATP-dependent mechanism: first demonstration of remote ischemic perconditioning.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Body Temperature; Ele | 2007 |
SCH 79797, a selective PAR1 antagonist, limits myocardial ischemia/reperfusion injury in rat hearts.
Topics: Androstadienes; Animals; Cardiotonic Agents; Disease Models, Animal; Dose-Response Relationship, Dru | 2007 |
Ischemic postconditioning reduces infarct size by activation of A1 receptors and K+(ATP) channels in both normal and hypercholesterolemic rabbits.
Topics: Adenosine A1 Receptor Antagonists; Analysis of Variance; Animals; Anti-Arrhythmia Agents; Coronary C | 2007 |
Mitochondria are targets for geranylgeranylacetone-induced cardioprotection against ischemia-reperfusion in the rat heart.
Topics: Animals; Anti-Arrhythmia Agents; Anti-Ulcer Agents; Cell Respiration; Cells, Cultured; Creatine Kina | 2007 |
Cardioprotection induced by hydrogen sulfide preconditioning involves activation of ERK and PI3K/Akt pathways.
Topics: Animals; Benzophenanthridines; Cardiotonic Agents; Cell Survival; Chromones; Disease Models, Animal; | 2008 |
(R)-ACX, a pancreatic beta-cell selective sulfonylurea, does not aggravate myocardial ischemia-reperfusion damage.
Topics: Action Potentials; Animals; Benzopyrans; Cells, Cultured; Female; Glyburide; Guinea Pigs; Hypoglycem | 2007 |
The hydrogen sulphide-releasing derivative of diclofenac protects against ischaemia-reperfusion injury in the isolated rabbit heart.
Topics: Animals; Creatine Kinase; Diclofenac; Epoprostenol; Glutathione; Glyburide; Heart; Hydrogen Sulfide; | 2008 |
Activation of kappa-opioid receptor as a method for prevention of ischemic and reperfusion arrhythmias: role of protein kinase C and K(ATP) channels.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Alkaloids; | 2007 |
H2S preconditioning-induced PKC activation regulates intracellular calcium handling in rat cardiomyocytes.
Topics: Alkaloids; Animals; Benzophenanthridines; Caffeine; Calcium; Cell Size; Cell Survival; Cells, Cultur | 2008 |
Hyperoxia confers myocardial protection in mechanically ventilated rats through the generation of free radicals and opening of mitochondrial ATP-sensitive potassium channels.
Topics: Acetylcysteine; Animals; Blood Pressure; Coronary Circulation; Decanoic Acids; Disease Models, Anima | 2008 |
Importance of timing of magnesium administration in the isolated ischemic-reperfused rat heart: role of K(ATP) channels.
Topics: Animals; Cardiotonic Agents; Coronary Circulation; Diazoxide; Drug Administration Schedule; Glyburid | 2008 |
Cardioprotection by L-glutamate during postischaemic reperfusion: reduced infarct size and enhanced glycogen resynthesis in a rat insulin-free heart model.
Topics: Aminooxyacetic Acid; Animals; Enzyme Inhibitors; Glutamic Acid; Glyburide; Glycogen; Hypoglycemic Ag | 2008 |
Effect of pressure overload on cardioprotection of mitochondrial KATP channels and GSK-3beta: interaction with the MPT pore.
Topics: Animals; Cardiotonic Agents; Cyclosporine; Diazoxide; Disease Models, Animal; Glyburide; Glycogen Sy | 2008 |
KR-31762, a novel KATP channel opener, exerts cardioprotective effects by opening SarcKATP channels in rat models of ischemia/reperfusion-induced heart injury.
Topics: Animals; Aorta; Benzopyrans; Cardiotonic Agents; Decanoic Acids; Disease Models, Animal; Dose-Respon | 2008 |
Exogenous hydrogen sulfide postconditioning protects isolated rat hearts against ischemia-reperfusion injury.
Topics: Animals; Blood Pressure; Buffers; Coronary Circulation; Creatine Kinase; Decanoic Acids; Dose-Respon | 2008 |
Pharmacological evidence for the persistent activation of ATP-sensitive K+ channels in early phase of reperfusion and its protective role against myocardial stunning.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Benzopyrans; Cromakalim; G | 1995 |
Ventricular overdrive pacing-induced preconditioning and no-flow ischemia-induced preconditioning in isolated working rat hearts.
Topics: Animals; Benzopyrans; Blood Pressure; Cardiac Pacing, Artificial; Coronary Circulation; Cromakalim; | 1995 |
Blockade of ATP-sensitive potassium channels by 5-hydroxydecanoate suppresses monophasic action potential shortening during regional myocardial ischemia.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bl | 1994 |
The ATP-dependent potassium channel: an endogenous cardioprotective mechanism.
Topics: Acetylcholine; Adenosine; Animals; Anti-Arrhythmia Agents; Coronary Disease; Decanoic Acids; Disease | 1994 |
Effect of potassium on the action of the KATP modulators cromakalim, pinacidil, or glibenclamide on arrhythmias in isolated perfused rat heart subjected to regional ischaemia.
Topics: Animals; Arrhythmias, Cardiac; Benzopyrans; Cromakalim; Glyburide; Guanidines; Heart; Heart Rate; My | 1994 |
Cardioprotection with U-89232 is not reversible with glibenclamide: evidence of a novel anti-ischemic agent derived from cromakalim.
Topics: Animals; Benzopyrans; Cromakalim; Female; Glyburide; Guanidines; Heart; Hemodynamics; Male; Myocardi | 1994 |
The ATP-regulated potassium channel in ischemia-reperfusion injury.
Topics: Adenosine Triphosphate; Animals; Dogs; Glyburide; Ion Channel Gating; Myocardial Contraction; Myocar | 1994 |
Effects of ATP-dependent K+ channel modulators on an ischemia-reperfusion rabbit isolated heart model with programmed electrical stimulation.
Topics: Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Benzopyrans; Blood Pressure; Coronary Circula | 1994 |
Effect of nicorandil on post-ischaemic contractile dysfunction in the heart: roles of its ATP-sensitive K+ channel opening property and nitrate property.
Topics: Adenosine Triphosphate; Animals; Glyburide; Hemodynamics; Infusions, Intravenous; Ion Channel Gating | 1993 |
Potassium channel openers and blockers: do they possess proarrhythmic or antiarrhythmic activity in ischemic and reperfused rat hearts?
Topics: Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Arrhythmias, Cardiac; Benzopyrans; Cations | 1993 |
The protection by ischemic preconditioning against myocardial ischemia- and reperfusion-induced arrhythmias is not mediated by ATP-sensitive potassium channels in rats.
Topics: Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Glyburide; Hemodynamics; Male; Myocardial Isc | 1993 |
Adenosine triphosphate-sensitive potassium channel blocking agent ameliorates, but the opening agent aggravates, ischemia/reperfusion-induced injury. Heart function studies in nonfibrillating isolated hearts.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Benzopyrans; Croma | 1994 |
Glibenclamide antagonizes adenosine A1 receptor-mediated cardioprotection in stunned canine myocardium.
Topics: Adenosine; Adenosine Triphosphate; Animals; Dogs; Female; Glyburide; Male; Myocardial Contraction; M | 1993 |
Limitation of infarct size in the rabbit by ischaemic preconditioning is reversible with glibenclamide.
Topics: Animals; Blood Glucose; Female; Glyburide; Male; Myocardial Infarction; Myocardial Ischemia; Myocard | 1993 |
Protection from ischaemic-reperfusion injury with adenosine pretreatment is reversed by inhibition of ATP sensitive potassium channels.
Topics: Adenosine; Adenosine Triphosphate; Animals; Disease Models, Animal; Dose-Response Relationship, Drug | 1993 |
Glibenclamide does not abolish the protective effect of preconditioning on stunning in the isolated perfused rat heart.
Topics: Animals; Disease Models, Animal; Glyburide; Hydrogen-Ion Concentration; Magnetic Resonance Spectrosc | 1993 |
Are ATP sensitive potassium channels involved in the pronounced antiarrhythmic effects of preconditioning?
Topics: Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Dogs; Female; Glyburide; Male; Myocardial Isc | 1993 |
Relationship of severity of myocardial stunning to ATP dependent potassium channel modulation.
Topics: Adenosine Triphosphate; Animals; Coronary Circulation; Dogs; Glyburide; Myocardial Contraction; Myoc | 1993 |
Preconditioning with potassium channel openers. A new concept for enhancing cardioplegic protection?
Topics: Animals; Coronary Circulation; Glyburide; Heart Arrest, Induced; Male; Myocardial Ischemia; Myocardi | 1995 |
Reduction by prostaglandin E1 or prostaglandin E0 of myocardial infarct size in the rabbit by activation of ATP-sensitive potassium channels.
Topics: Adenosine Triphosphate; Alprostadil; Animals; Anti-Arrhythmia Agents; Biotransformation; Blood Press | 1995 |
Endothelin-1-induced reduction of myocardial infarct size by activation of ATP-sensitive potassium channels in a rabbit model of myocardial ischaemia and reperfusion.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Arterial Occlusive Diseases; Blood Pressure | 1995 |
KATP channel modulation in working rat hearts with coronary occlusion: effects of cromakalim, cicletanine, and glibenclamide.
Topics: Animals; Anti-Arrhythmia Agents; Benzopyrans; Coronary Circulation; Coronary Disease; Cromakalim; Gl | 1995 |
Glyburide-reversible cardioprotective effects of calcium-independent phospholipase A2 inhibition in ischemic rat hearts.
Topics: Animals; Anti-Arrhythmia Agents; Calcium; Coronary Circulation; Decanoic Acids; Dose-Response Relati | 1996 |
Effects of glibenclamide and nicorandil in post-ischaemic contractile dysfunction of perfused hearts in normotensive and spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Cardiac Volume; Creatine Kinase; Glyburide; Heart Rate; Hemodynamics; Hyper | 1996 |
Cardioprotective effects of NIP-121, a novel ATP-sensitive potassium channel opener, during ischemia and reperfusion in coronary perfused guinea pig myocardium.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Glyburide; Guinea Pigs; Myocardial Contraction; | 1996 |
Mechanism of myocardial protection by isoflurane. Role of adenosine triphosphate-regulated potassium (KATP) channels.
Topics: Adenosine Triphosphate; Anesthetics, Inhalation; Animals; Coronary Circulation; Dogs; Drug Interacti | 1996 |
Effects of cromakalim and glibenclamide in ischemic and reperfused hearts.
Topics: Animals; Anti-Arrhythmia Agents; Benzopyrans; Cromakalim; Diabetes Mellitus, Experimental; Glyburide | 1996 |
Y-26763 protects the working rat myocardium from ischemia/reperfusion injury through opening of KATP channels.
Topics: Adenosine Triphosphate; Animals; Antihypertensive Agents; Benzopyrans; Energy Metabolism; Glyburide; | 1996 |
Effect of timing of treatment of the glyburide-reversible cardioprotective activity of BMS-180448.
Topics: Animals; Benzopyrans; Calcium; Ferrets; Glyburide; Guanidines; Heart; In Vitro Techniques; Male; Myo | 1997 |
KATP channel modulators increase survival rate during coronary occlusion-reperfusion in anaesthetized rats.
Topics: Action Potentials; Adenosine Triphosphate; Analysis of Variance; Animals; Anti-Arrhythmia Agents; Ar | 1997 |
Concerning the effect of the K+ channel blocking agent glibenclamide on ischaemic and reperfusion arrhythmias.
Topics: Adenosine; Animals; Arrhythmias, Cardiac; Coronary Circulation; Drug Evaluation, Preclinical; Glybur | 1997 |
Effect of glimepiride and glibenclamide, inhibitors of ATP-dependent K(+)-channel, on ischaemia-reperfusion induced arrhythmias in rats.
Topics: Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Dose-Response Relationship, Drug; Glyburide; | 1996 |
Inhibitors of nitric oxide synthesis and ischemia/reperfusion attenuate coronary vasodilator response to pinacidil in isolated rat heart.
Topics: Animals; Coronary Vessels; Glyburide; Guanidines; Heart; In Vitro Techniques; Male; Myocardial Reper | 1997 |
Proarrhythmic effects of pinacidil are partially mediated through enhancement of catecholamine release in isolated perfused guinea-pig hearts.
Topics: Adenosine Triphosphate; Adrenergic Agonists; Adrenergic beta-Antagonists; Animals; Arrhythmias, Card | 1998 |
Cardioprotective effects of KR-30450, a novel K+(ATP) opener, and its major metabolite KR-30818 on isolated rat hearts.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Glyburi | 1998 |
Monophosphoryl lipid A attenuates myocardial stunning in dogs: role of ATP-sensitive potassium channels.
Topics: Adenosine Triphosphate; Animals; Blood Gas Analysis; Blood Pressure; Coronary Circulation; Decanoic | 1998 |
Selective activation of adenosine A3 receptors with N6-(3-chlorobenzyl)-5'-N-methylcarboxamidoadenosine (CB-MECA) provides cardioprotection via KATP channel activation.
Topics: Adenosine; Adenylyl Cyclases; Animals; Anti-Arrhythmia Agents; Binding, Competitive; CHO Cells; Colf | 1998 |
Comparison of the efficacy of glibenclamide and glimepiride in reperfusion-induced arrhythmias in rats.
Topics: Anesthesia; Animals; Arrhythmias, Cardiac; Blood Glucose; Blood Pressure; Coronary Vessels; Glyburid | 1999 |
KATP channel modulators and myocardial damages induced by ischemia-reperfusion: membrane lipids injury and arrhythmias.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Cromakalim; Electrophysiology; Fatty Acids, Nonest | 1998 |
Opioid-induced second window of cardioprotection: potential role of mitochondrial KATP channels.
Topics: Analgesics; Animals; Benzylidene Compounds; Blood Pressure; Coronary Circulation; Glyburide; Hypogly | 1999 |
Relationship between myocardial cation content and injury in reperfused rat hearts treated with cation channel blockers.
Topics: Animals; Anti-Arrhythmia Agents; Calcium Channel Blockers; Cations; Creatine Kinase; Diltiazem; Dose | 1999 |
Levosimendan: effects of a calcium sensitizer on function and arrhythmias and cyclic nucleotide levels during ischemia/reperfusion in the Langendorff-perfused guinea pig heart.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium Channel Agoni | 1999 |
KATP channels and 'border zone' arrhythmias: role of the repolarization dispersion between normal and ischaemic ventricular regions.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; ATP-Binding Cassette Transporters; Benzopyrans; Di | 1999 |
Cardioprotective effects of propofol and sevoflurane in ischemic and reperfused rat hearts: role of K(ATP) channels and interaction with the sodium-hydrogen exchange inhibitor HOE 642 (cariporide).
Topics: Adenosine Triphosphate; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Biotransformatio | 1999 |
The effects of a newly synthesized ATP-sensitive potassium channel opener, MJ-355, on blood pressure and myocardial ischemia-reperfusion injury in rats.
Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Arrhythmias, Cardiac; ATP-Bind | 1999 |
Participation of prostaglandin E2 in the endothelial protective effect of ischaemic preconditioning in isolated rat heart.
Topics: 6-Ketoprostaglandin F1 alpha; Alkaloids; Analysis of Variance; Animals; Benzophenanthridines; Corona | 2000 |
Reduction of postischemic contractile dysfunction of the isolated rat heart by sevoflurane: comparison with halothane.
Topics: Adenine Nucleotides; Anesthetics, Inhalation; Animals; Glyburide; Halothane; Heart Arrest, Induced; | 2000 |
Fibroblast growth factor cardioprotection against ischemia-reperfusion injury may involve K+ ATP channels.
Topics: Adenosine Triphosphate; Animals; Creatine Kinase; Enzyme Activation; Fibroblast Growth Factor 1; Fib | 2000 |
Heat stress-induced protection of endothelial function against ischaemic injury is abolished by ATP-sensitive potassium channel blockade in the isolated rat heart.
Topics: Animals; ATP-Binding Cassette Transporters; Blood Pressure; Endothelium, Vascular; Glyburide; Heart | 2000 |
Inhibitors of ischemic preconditioning do not attenuate Na+/H+ exchange inhibitor mediated cardioprotection.
Topics: Animals; Benzamides; Dogs; Female; Glyburide; Hemodynamics; Hypoglycemic Agents; Ischemic Preconditi | 2000 |
Dual roles of mitochondrial K(ATP) channels in diazoxide-mediated protection in isolated rabbit hearts.
Topics: Adenosine Triphosphate; Animals; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Diazox | 2001 |
A K(ATP) channel opener inhibited myocardial reperfusion action potential shortening and arrhythmias.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Antihypertensive Agents; Arrhythmias, Cardiac; B | 2001 |
Ketamine, but not S(+)-ketamine, blocks ischemic preconditioning in rabbit hearts in vivo.
Topics: Anesthesia; Animals; Glyburide; Heart; Hemodynamics; Ischemic Preconditioning; Ketamine; Male; Myoca | 2001 |
Relation of cyclic nucleotide ratios to ischemic and reperfusion injury in nitric oxide-donor treated rat hearts.
Topics: Animals; Anti-Arrhythmia Agents; Glyburide; In Vitro Techniques; Male; Myocardial Contraction; Myoca | 2001 |
Critical timing of mitochondrial K(ATP) channel opening for enhancement of myocardial tolerance against infarction.
Topics: Animals; Anti-Arrhythmia Agents; Coronary Circulation; Decanoic Acids; Diazoxide; Glyburide; Hydroxy | 2001 |
Exercise training alters an anoxia-induced, glibenclamide-sensitive current in rat ventricular cardiocytes.
Topics: Adenosine Triphosphate; Animals; Female; Glyburide; Heart Ventricles; Hypoglycemic Agents; Hypoxia; | 2002 |
ATP-sensitive potassium channels do not have a main role in mediating late preconditioning protection against arrhythmias and stunning in conscious sheep.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Co | 2002 |
Nicorandil attenuates myocardial dysfunction associated with transient ischemia by opening ATP-dependent potassium channels.
Topics: Adenosine Triphosphate; Animals; Blood Glucose; Blood Pressure; Coronary Circulation; Dogs; Female; | 1992 |
Pharmacological evidence for a role of ATP-dependent potassium channels in myocardial stunning.
Topics: Adenosine Triphosphate; Animals; Blood Glucose; Dogs; Female; Glyburide; Hemodynamics; Male; Myocard | 1992 |
Differential effects of glyburide on premature beats and ventricular tachycardia in an isolated tissue model of ischemia and reperfusion.
Topics: Action Potentials; Animals; Cardiac Complexes, Premature; Electric Stimulation; Electrocardiography; | 1992 |
Influence of ATP-sensitive potassium channel blocker on hypoxia-induced damage of isolated guinea pig heart.
Topics: Adenosine Triphosphate; Animals; Glyburide; Guinea Pigs; Heart Rate; Hypoxia; L-Lactate Dehydrogenas | 1992 |
Effect of the potassium channel opener EMD 56431 on globally ischemic rat hearts.
Topics: Animals; Benzopyrans; Coronary Circulation; Glyburide; Hemodynamics; L-Lactate Dehydrogenase; Male; | 1992 |
The new K+ channel opener Aprikalim (RP 52891) reduces experimental infarct size in dogs in the absence of hemodynamic changes.
Topics: Animals; Blood Glucose; Coronary Circulation; Coronary Vessels; Dogs; Female; Glyburide; Hemodynamic | 1991 |
ATP-regulated K+ channels protect the myocardium against ischemia/reperfusion damage.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Coronary Disease; Glyburide; Guanidines; Guinea | 1991 |
Reduction of ischemic damage in isolated rat hearts by the potassium channel opener, RP 52891.
Topics: Adenosine Triphosphate; Animals; Coronary Disease; Decanoic Acids; Glyburide; Heart; Hydroxy Acids; | 1990 |