glyburide has been researched along with Infarction, Middle Cerebral Artery in 7 studies
Glyburide: An antidiabetic sulfonylurea derivative with actions like those of chlorpropamide
glyburide : An N-sulfonylurea that is acetohexamide in which the acetyl group is replaced by a 2-(5-chloro-2-methoxybenzamido)ethyl group.
Infarction, Middle Cerebral Artery: NECROSIS occurring in the MIDDLE CEREBRAL ARTERY distribution system which brings blood to the entire lateral aspects of each CEREBRAL HEMISPHERE. Clinical signs include impaired cognition; APHASIA; AGRAPHIA; weak and numbness in the face and arms, contralaterally or bilaterally depending on the infarction.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Using a transient middle cerebral artery occlusion (tMCAo) rodent model of stroke, we studied two rat cohorts, one without rt-PA and a second cohort treated with rt-PA." | 1.62 | Continuous Glibenclamide Prevents Hemorrhagic Transformation in a Rodent Model of Severe Ischemia-Reperfusion. ( Igarashi, T; Kimberly, WT; Sastre, C; Wolcott, Z, 2021) |
| "To create HT model, right middle cerebral artery occlusion (MCAO) was conducted with intraluminal thread technique; 30 min after MCAO, 50 microL arterial blood was injected into the caudate nucleus where the infarction occurred." | 1.35 | Brain damage related to hemorrhagic transformation following cerebral ischemia and the role of K ATP channels. ( Li, LT; Yang, Y; Yin, J; Zhang, XJ, 2008) |
| "Isoflurane was applied after OGD." | 1.35 | Postconditioning with isoflurane reduced ischemia-induced brain injury in rats. ( Jung, HH; Lee, JJ; Li, L; Zuo, Z, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (57.14) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 2 (28.57) | 2.80 |
| Authors | Studies |
|---|---|
| Payabvash, S | 1 |
| Falcone, GJ | 1 |
| Sze, GK | 1 |
| Jain, A | 1 |
| Beslow, LA | 1 |
| Petersen, NH | 1 |
| Sheth, KN | 1 |
| Kimberly, WT | 2 |
| Igarashi, T | 1 |
| Sastre, C | 1 |
| Wolcott, Z | 1 |
| Wu, Z | 1 |
| Zhu, SZ | 1 |
| Hu, YF | 1 |
| Gu, Y | 1 |
| Wang, SN | 1 |
| Lin, ZZ | 1 |
| Xie, ZS | 1 |
| Pan, SY | 1 |
| Yang, Y | 1 |
| Zhang, XJ | 1 |
| Yin, J | 1 |
| Li, LT | 1 |
| Simard, JM | 1 |
| Yurovsky, V | 1 |
| Tsymbalyuk, N | 1 |
| Melnichenko, L | 1 |
| Ivanova, S | 1 |
| Gerzanich, V | 1 |
| Horiguchi, T | 1 |
| Kis, B | 1 |
| Rajapakse, N | 1 |
| Shimizu, K | 1 |
| Busija, DW | 1 |
| Lee, JJ | 1 |
| Li, L | 1 |
| Jung, HH | 1 |
| Zuo, Z | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized, Multi-Center, Prospective, Double Blind, Phase II Trial of RP- 1127 (Glyburide for Injection) in Patients With a Severe Anterior Circulation Ischemic Stroke Who Are Likely to Develop Malignant Edema[NCT01794182] | Phase 2 | 86 participants (Actual) | Interventional | 2013-06-13 | Completed | ||
| Inhalatorial Sedation in Patient With SAH Versus Conventional Intravenous Sedation (GAS-SAH)[NCT00830843] | Phase 4 | 13 participants (Actual) | Interventional | 2009-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 other studies available for glyburide and Infarction, Middle Cerebral Artery
| Article | Year |
|---|---|
Poor Outcomes Related to Anterior Extension of Large Hemispheric Infarction: Topographic Analysis of GAMES-RP Trial MRI Scans.
Topics: Administration, Intravenous; Aged; Anterior Cerebral Artery; Cerebrovascular Circulation; Cerebrum; | 2020 |
Continuous Glibenclamide Prevents Hemorrhagic Transformation in a Rodent Model of Severe Ischemia-Reperfusion.
Topics: Animals; Brain Edema; Disease Models, Animal; Fibrinolytic Agents; Glyburide; Infarction, Middle Cer | 2021 |
Glibenclamide enhances the effects of delayed hypothermia after experimental stroke in rats.
Topics: Animals; Blood-Brain Barrier; Brain Edema; Cyclooxygenase 2; Encephalitis; Glyburide; Hyperthermia, | 2016 |
Brain damage related to hemorrhagic transformation following cerebral ischemia and the role of K ATP channels.
Topics: Adenosine Triphosphatases; Animals; Brain; Brain Edema; Brain Infarction; Brain Ischemia; Cerebral H | 2008 |
Protective effect of delayed treatment with low-dose glibenclamide in three models of ischemic stroke.
Topics: Animals; ATP-Binding Cassette Transporters; Brain; Brain Ischemia; Cerebral Infarction; Data Interpr | 2009 |
Opening of mitochondrial ATP-sensitive potassium channels is a trigger of 3-nitropropionic acid-induced tolerance to transient focal cerebral ischemia in rats.
Topics: Adenosine Triphosphate; Animals; Cells, Cultured; Cerebral Cortex; Decanoic Acids; Glyburide; Hydrox | 2003 |
Postconditioning with isoflurane reduced ischemia-induced brain injury in rats.
Topics: Anesthetics, Inhalation; Animals; Brain; Decanoic Acids; Dose-Response Relationship, Drug; Glyburide | 2008 |