glyburide has been researched along with Hypertrichosis in 5 studies
Glyburide: An antidiabetic sulfonylurea derivative with actions like those of chlorpropamide
glyburide : An N-sulfonylurea that is acetohexamide in which the acetyl group is replaced by a 2-(5-chloro-2-methoxybenzamido)ethyl group.
Hypertrichosis: Excessive hair growth at inappropriate locations, such as on the extremities, the head, and the back. It is caused by genetic or acquired factors, and is an androgen-independent process. This concept does not include HIRSUTISM which is an androgen-dependent excess hair growth in WOMEN and CHILDREN.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Using combined transgenic and pharmacological approaches in a knockin mouse model of CS, we have shown that reversal of vascular and cardiac phenotypes can be achieved by genetic downregulation of KATP channel activity specifically in VSM, and by chronic administration of the clinically used KATP channel inhibitor, glibenclamide." | 1.56 | Glibenclamide reverses cardiovascular abnormalities of Cantu syndrome driven by KATP channel overactivity. ( Chalk, R; Halabi, CM; Harter, TM; Huang, Y; Kovacs, A; McClenaghan, C; Nichols, CG; Remedi, MS; van Haaften, G; Yan, Z, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 2 (40.00) | 2.80 |
| Authors | Studies |
|---|---|
| McClenaghan, C | 3 |
| Huang, Y | 1 |
| Yan, Z | 1 |
| Harter, TM | 1 |
| Halabi, CM | 1 |
| Chalk, R | 1 |
| Kovacs, A | 1 |
| van Haaften, G | 2 |
| Remedi, MS | 1 |
| Nichols, CG | 3 |
| Zhao, G | 1 |
| Kaplan, A | 1 |
| Greiser, M | 1 |
| Lederer, WJ | 1 |
| Cooper, PE | 1 |
| Chen, X | 2 |
| Stary-Weinzinger, A | 2 |
| Houtman, MJC | 1 |
| Qile, M | 1 |
| Duran, K | 1 |
| van der Heyden, MAG | 1 |
| Ma, A | 1 |
| Gurnasinghani, S | 1 |
| Kirk, EP | 1 |
| Singh, GK | 1 |
| Grange, DK | 1 |
| Pandit, C | 1 |
| Zhu, Y | 1 |
| Roscioli, T | 1 |
| Elakis, G | 1 |
| Buckley, M | 1 |
| Mehta, B | 1 |
| Roberts, P | 1 |
| Mervis, J | 1 |
| Biggin, A | 1 |
5 other studies available for glyburide and Hypertrichosis
| Article | Year |
|---|---|
Glibenclamide reverses cardiovascular abnormalities of Cantu syndrome driven by KATP channel overactivity.
Topics: Animals; Cardiomegaly; Disease Models, Animal; Gene Knock-In Techniques; Glyburide; Humans; Hypertri | 2020 |
The surprising complexity of KATP channel biology and of genetic diseases.
Topics: Animals; Cardiomegaly; Cardiovascular Abnormalities; Glyburide; Hypertrichosis; Mice; Osteochondrody | 2020 |
Conserved functional consequences of disease-associated mutations in the slide helix of Kir6.1 and Kir6.2 subunits of the ATP-sensitive potassium channel.
Topics: Amino Acid Substitution; Animals; Cardiomegaly; Chlorocebus aethiops; COS Cells; Glyburide; Humans; | 2017 |
Glibenclamide and HMR1098 normalize Cantú syndrome-associated gain-of-function currents.
Topics: Adenosine Triphosphate; Cardiomegaly; Cryoelectron Microscopy; Gain of Function Mutation; Gene Expre | 2019 |
Glibenclamide treatment in a Cantú syndrome patient with a pathogenic ABCC9 gain-of-function variant: Initial experience.
Topics: Alleles; Cardiomegaly; Echocardiography; Female; Gain of Function Mutation; Genetic Association Stud | 2019 |