Page last updated: 2024-10-28

glyburide and Hyperemia

glyburide has been researched along with Hyperemia in 34 studies

Glyburide: An antidiabetic sulfonylurea derivative with actions like those of chlorpropamide
glyburide : An N-sulfonylurea that is acetohexamide in which the acetyl group is replaced by a 2-(5-chloro-2-methoxybenzamido)ethyl group.

Hyperemia: The presence of an increased amount of blood in a body part or an organ leading to congestion or engorgement of blood vessels. Hyperemia can be due to increase of blood flow into the area (active or arterial), or due to obstruction of outflow of blood from the area (passive or venous).

Research Excerpts

ExcerptRelevanceReference
"We have previously demonstrated that adenosine-mediated H2O2 production and opening of ATP-sensitive K(+) (KATP) channels contributes to coronary reactive hyperemia."7.80Metabolic hyperemia requires ATP-sensitive K+ channels and H2O2 but not adenosine in isolated mouse hearts. ( Ledent, C; Mustafa, SJ; Teng, B; Tilley, S; Zhou, X, 2014)
"Myocardial metabolites such as adenosine mediate reactive hyperemia, in part, by activating ATP-dependent K(+) (K(ATP)) channels in coronary smooth muscle."7.79Interactions between A(2A) adenosine receptors, hydrogen peroxide, and KATP channels in coronary reactive hyperemia. ( Asano, S; Dick, GM; Ledent, C; Mustafa, SJ; Sharifi-Sanjani, M; Teng, B; Tilley, S; Zhou, X, 2013)
"The effect of glyburide on coronary reactive hyperemia and dilator responses to adenosine was evaluated in isolated perfused guinea pig hearts and anesthetized dogs."7.68Coronary reactive hyperemia and adenosine-induced vasodilation are mediated partially by a glyburide-sensitive mechanism. ( Clayton, FC; Grover, GJ; Hess, TA; Smith, MA, 1992)
"Post-occlusive reactive hyperemia (PORH) following arterial occlusion is widely used to assess cutaneous microvascular function, though the underlying mechanisms remain to be fully elucidated."6.94Tetraethylammonium, glibenclamide, and 4-aminopyridine modulate post-occlusive reactive hyperemia in non-glabrous human skin with no roles of NOS and COX. ( Fujii, N; Ichinose, M; Kenny, GP; McGarr, GW; Nishiyasu, T, 2020)
"We have previously demonstrated that adenosine-mediated H2O2 production and opening of ATP-sensitive K(+) (KATP) channels contributes to coronary reactive hyperemia."3.80Metabolic hyperemia requires ATP-sensitive K+ channels and H2O2 but not adenosine in isolated mouse hearts. ( Ledent, C; Mustafa, SJ; Teng, B; Tilley, S; Zhou, X, 2014)
"Myocardial metabolites such as adenosine mediate reactive hyperemia, in part, by activating ATP-dependent K(+) (K(ATP)) channels in coronary smooth muscle."3.79Interactions between A(2A) adenosine receptors, hydrogen peroxide, and KATP channels in coronary reactive hyperemia. ( Asano, S; Dick, GM; Ledent, C; Mustafa, SJ; Sharifi-Sanjani, M; Teng, B; Tilley, S; Zhou, X, 2013)
"This study was designed to elucidate the contribution of adenosine A(2A) and A(2B) receptors to coronary reactive hyperemia and downstream K(+) channels involved."3.76Contribution of adenosine A(2A) and A(2B) receptors to ischemic coronary dilation: role of K(V) and K(ATP) channels. ( Berwick, ZC; Dick, GM; Lynch, B; Payne, GA; Sturek, M; Tune, JD, 2010)
"Glibenclamide, iberiotoxin, and apamin (blockers of ATP-sensitive, large-conductance, and small-conductance Ca(2+)-activated K+ channels, respectively) were infused into the diaphragmatic vasculature of anesthetized indomethacin-treated dogs to assess the contribution of K+ channels to active hyperemia."3.69Contribution of potassium channels to active hyperemia of the canine diaphragm. ( Chang, HY; Gatensby, AG; Hussain, SN; Vanelli, G, 1994)
"Glibenclamide, iberiotoxin, and apamin (blockers of ATP-sensitive, large-conductance, and small-conductance Ca(2+)-activated potassium channels, respectively) were infused into the diaphragmatic vasculature of anesthetized dogs to assess the contribution of these channels in the regulation of basal tone and the response to brief occlusions of the left phrenic artery (reactive hyperemia)."3.69Effects of potassium channel blockers on basal vascular tone and reactive hyperemia of canine diaphragm. ( Hussain, SN; Vanelli, G, 1994)
" Studies were conducted under control conditions and in the presence of four inhibitors of potential mediators of the reactive hyperemia response: the nitric oxide synthase inhibitor NG-nitro-L-arginine methyl ester (30 microM), the adenosine antagonist 8-(p-sulfophenyl)theophylline (50 microM), the K+ cyclic adenosine triphosphate-dependent channel antagonist glibenclamide (10 microM), and the cyclooxygenase inhibitor indomethacin (10 microM)."3.69Myocardial reactive hyperemia in experimental chronic heart failure: evidence for the role of K+ adenosine triphosphate-dependent channels and cyclooxygenase activity. ( Dumont, L; Fontaine, E; Jasmin, G; VĂ©ronneau, M; Viau, S, 1997)
"Post-occlusive reactive hyperemia (PORH) following arterial occlusion is widely used to assess cutaneous microvascular function, though the underlying mechanisms remain to be fully elucidated."2.94Tetraethylammonium, glibenclamide, and 4-aminopyridine modulate post-occlusive reactive hyperemia in non-glabrous human skin with no roles of NOS and COX. ( Fujii, N; Ichinose, M; Kenny, GP; McGarr, GW; Nishiyasu, T, 2020)
" After dosing glibenclamide induced a significant (P = 0."2.71Forearm vascular reactivity is differentially influenced by gliclazide and glibenclamide in chronically treated type 2 diabetic patients. ( Boes, U; Wascher, TC, 2005)
"Reactive hyperemia was expressed in terms of peak post-occlusive flow, duration of hyperemia and reactive hyperemic volume."2.68Acute effects of glyburide on the regulation of peripheral blood flow in normal humans. ( Hussain, SN; Kosmas, EN; Levy, RD, 1995)
" In resistance vessels, venous occlusion plethysmography was used to measure the dilator response to acetylcholine (ACh) [area under ACh dose-response curve (ACh AUC)]."1.37Postconditioning protects against human endothelial ischaemia-reperfusion injury via subtype-specific KATP channel activation and is mimicked by inhibition of the mitochondrial permeability transition pore. ( Bhavsar, DD; Charakida, M; Deanfield, JE; Loukogeorgakis, SP; MacAllister, RJ; Okorie, MI; Ridout, D, 2011)
"Reactive hyperemia was induced following 30 sec and 300 sec of no-flow ischemia of the heart."1.30Types of potassium channels involved in coronary reactive hyperemia depend on duration of preceding ischemia in rat hearts. ( Ito, T; Mokuno, S; Murase, K; Okumura, K; Shinoda, M; Toki, Y, 1997)
"The mechanism underlying reactive hyperemia was investigated in the feline hindquarters vascular bed under natural- and constant-flow conditions."1.29Role of K+ATP channels and EDRF in reactive hyperemia in the hindquarters vascular bed of cats. ( Kadowitz, PJ; McMahon, TJ; Minkes, RK; Santiago, JA, 1995)
"In the early phase of reactive hyperemia, all arterial microvessels dilated, and the magnitude of peak dilation was greater in vessels smaller than 100 microns compared with those larger than 100 microns."1.28Microvascular sites and mechanisms responsible for reactive hyperemia in the coronary circulation of the beating canine heart. ( Akai, K; Ashikawa, K; Kanatsuka, H; Komaru, T; Sato, K; Sekiguchi, N; Takishima, T; Wang, Y, 1992)
"The mechanism of reactive hyperemia remains unknown."1.28Blockade of the ATP-sensitive potassium channel modulates reactive hyperemia in the canine coronary circulation. ( Aversano, T; Ouyang, P; Silverman, H, 1991)

Research

Studies (34)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's16 (47.06)18.2507
2000's11 (32.35)29.6817
2010's6 (17.65)24.3611
2020's1 (2.94)2.80

Authors

AuthorsStudies
Fujii, N1
McGarr, GW1
Ichinose, M1
Nishiyasu, T1
Kenny, GP1
Sharifi-Sanjani, M1
Zhou, X2
Asano, S1
Tilley, S2
Ledent, C2
Teng, B2
Dick, GM2
Mustafa, SJ2
Holdsworth, CT1
Copp, SW1
Ferguson, SK1
Sims, GE1
Poole, DC1
Musch, TI1
Matheson, PJ1
Li, N1
Harris, PD1
Zakaria, el R1
Garrison, RN1
Berwick, ZC1
Payne, GA1
Lynch, B1
Sturek, M1
Tune, JD1
Okorie, MI1
Bhavsar, DD1
Ridout, D1
Charakida, M1
Deanfield, JE2
Loukogeorgakis, SP2
MacAllister, RJ2
Capecchi, PL1
Guideri, F1
Colafati, M1
Acampa, M1
Cuomo, A1
Lazzerini, PE1
Pasini, FL1
Farouque, HM3
Meredith, IT3
Worthley, SG1
Wascher, TC1
Boes, U1
Schrage, WG1
Dietz, NM1
Joyner, MJ1
Cankar, K1
Strucl, M1
Williams, R1
Panagiotidou, AT1
Kolvekar, SK1
Donald, A1
Cole, TJ1
Yellon, DM1
Wang, SY1
Friedman, M1
Johnson, RG1
Zeind, AJ1
Sellke, FW1
Minkes, RK1
Santiago, JA1
McMahon, TJ1
Kadowitz, PJ1
Vanelli, G2
Chang, HY1
Gatensby, AG1
Hussain, SN3
Yada, T1
Hiramatsu, O1
Kimura, A1
Tachibana, H1
Chiba, Y1
Lu, S1
Goto, M1
Ogasawara, Y1
Tsujioka, K1
Kajiya, F1
Kosmas, EN1
Levy, RD1
Duncker, DJ2
van Zon, NS1
Pavek, TJ1
Herrlinger, SK1
Bache, RJ2
Saito, Y1
McKay, M1
Eraslan, A1
Hester, RL1
Gidday, JM1
Maceren, RG1
Shah, AR1
Meier, JA1
Zhu, Y1
Shinoda, M1
Toki, Y1
Murase, K1
Mokuno, S1
Okumura, K1
Ito, T1
Viau, S1
Fontaine, E1
VĂ©ronneau, M1
Jasmin, G1
Dumont, L1
Iwata, F1
Koo, A1
Itoh, M1
Lam, K1
Leung, JW1
Leung, FW1
Ishibashi, Y1
Zhang, J1
Bank, AJ1
Sih, R1
Mullen, K1
Osayamwen, M1
Lee, PC1
Phillis, JW1
Song, D1
O'Regan, MH1
Shimizu, K1
Bari, F1
Busija, DW1
Kanatsuka, H1
Sekiguchi, N1
Sato, K1
Akai, K1
Wang, Y1
Komaru, T1
Ashikawa, K1
Takishima, T1
Clayton, FC1
Hess, TA1
Smith, MA1
Grover, GJ1
Aversano, T1
Ouyang, P1
Silverman, H1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Randomised Controlled Trial of the Effect of Remote Ischaemic Conditioning on Coronary Endothelial Function in Patients With Angina.[NCT02666235]Phase 260 participants (Actual)Interventional2011-07-31Completed
Effect of Intermittent Hypoxia on Ischemia-reperfusion Injury in Healthy Individuals[NCT05423470]41 participants (Actual)Interventional2019-05-30Completed
The Effect of Remote Ischemic Conditioning (RIC) on Inflammatory Biomarkers and Outcomes in Patients With TBI[NCT03899532]120 participants (Anticipated)Interventional2019-09-24Recruiting
The Effect of Remote Ischemic Preconditioning on Myocardial Injury After Noncardiac Surgery in Patients at a High Risk of Cardiac Events[NCT05733208]766 participants (Anticipated)Interventional2023-05-06Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for glyburide and Hyperemia

ArticleYear
ATP-sensitive K+ channels, adenosine, and nitric oxide-mediated mechanisms account for coronary vasodilation during exercise.
    Circulation research, 1998, Feb-23, Volume: 82, Issue:3

    Topics: Adenosine; Adenosine Triphosphate; Animals; Coronary Disease; Coronary Vessels; Dogs; Enzyme Inhibit

1998

Trials

5 trials available for glyburide and Hyperemia

ArticleYear
Tetraethylammonium, glibenclamide, and 4-aminopyridine modulate post-occlusive reactive hyperemia in non-glabrous human skin with no roles of NOS and COX.
    Microcirculation (New York, N.Y. : 1994), 2020, Volume: 27, Issue:1

    Topics: 4-Aminopyridine; Adult; Glyburide; Humans; Hyperemia; Male; Nitric Oxide Synthase; Prostaglandin-End

2020
Acute effects of glibenclamide on reactive hyperaemia in the lower limbs in humans.
    Clinical hemorheology and microcirculation, 2002, Volume: 27, Issue:2

    Topics: Adult; Area Under Curve; Female; Glyburide; Humans; Hyperemia; Ischemia; Ischemic Preconditioning; L

2002
Forearm vascular reactivity is differentially influenced by gliclazide and glibenclamide in chronically treated type 2 diabetic patients.
    Clinical physiology and functional imaging, 2005, Volume: 25, Issue:1

    Topics: Adult; Analysis of Variance; Cross-Over Studies; Diabetes Mellitus, Type 2; Dose-Response Relationsh

2005
The effect of glibenclamide on cutaneous laser-Doppler flux.
    Microvascular research, 2008, Volume: 75, Issue:1

    Topics: Adult; Blood Flow Velocity; Cold Temperature; Dose-Response Relationship, Drug; Female; Glyburide; H

2008
Acute effects of glyburide on the regulation of peripheral blood flow in normal humans.
    European journal of pharmacology, 1995, Feb-14, Volume: 274, Issue:1-3

    Topics: Administration, Oral; Adult; Cross-Over Studies; Femoral Vein; Glyburide; Humans; Hyperemia; Leg; Ma

1995

Other Studies

28 other studies available for glyburide and Hyperemia

ArticleYear
Interactions between A(2A) adenosine receptors, hydrogen peroxide, and KATP channels in coronary reactive hyperemia.
    American journal of physiology. Heart and circulatory physiology, 2013, May-15, Volume: 304, Issue:10

    Topics: Adenosine; Animals; Catalase; Coronary Circulation; Coronary Vessels; Glyburide; Hydrogen Peroxide;

2013
Metabolic hyperemia requires ATP-sensitive K+ channels and H2O2 but not adenosine in isolated mouse hearts.
    American journal of physiology. Heart and circulatory physiology, 2014, Oct-01, Volume: 307, Issue:7

    Topics: Adenosine; Adenosine A2 Receptor Antagonists; Animals; Coronary Circulation; Free Radical Scavengers

2014
Acute inhibition of ATP-sensitive K+ channels impairs skeletal muscle vascular control in rats during treadmill exercise.
    American journal of physiology. Heart and circulatory physiology, 2015, Jun-01, Volume: 308, Issue:11

    Topics: Animals; Arterial Pressure; Glyburide; Hyperemia; Male; Muscle, Skeletal; Physical Exertion; Rats; R

2015
Glucose-induced intestinal vasodilation via adenosine A1 receptors requires nitric oxide but not K(+)(ATP) channels.
    The Journal of surgical research, 2011, Jun-15, Volume: 168, Issue:2

    Topics: Adenosine A1 Receptor Antagonists; Animals; Glucose; Glyburide; Hyperemia; Intestinal Absorption; Je

2011
Contribution of adenosine A(2A) and A(2B) receptors to ischemic coronary dilation: role of K(V) and K(ATP) channels.
    Microcirculation (New York, N.Y. : 1994), 2010, Volume: 17, Issue:8

    Topics: 4-Aminopyridine; Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Anima

2010
Postconditioning protects against human endothelial ischaemia-reperfusion injury via subtype-specific KATP channel activation and is mimicked by inhibition of the mitochondrial permeability transition pore.
    European heart journal, 2011, Volume: 32, Issue:10

    Topics: Acetylcholine; Adult; Analysis of Variance; Brachial Artery; Cyclosporine; Endothelium, Vascular; Fe

2011
Effects of inhibition of ATP-sensitive potassium channels on metabolic vasodilation in the human forearm.
    Clinical science (London, England : 1979), 2003, Volume: 104, Issue:1

    Topics: Adenosine Triphosphate; Adult; Dose-Response Relationship, Drug; Female; Forearm; Gliclazide; Glybur

2003
Inhibition of vascular ATP-sensitive K+ channels does not affect reactive hyperemia in human forearm.
    American journal of physiology. Heart and circulatory physiology, 2003, Volume: 284, Issue:2

    Topics: Adenosine Triphosphate; Adult; Blood Vessels; Diazoxide; Female; Forearm; Glyburide; Humans; Hyperem

2003
Effect of ATP-sensitive potassium channel inhibition on coronary metabolic vasodilation in humans.
    Arteriosclerosis, thrombosis, and vascular biology, 2004, Volume: 24, Issue:5

    Topics: Adenosine Triphosphate; Aged; Angioplasty, Balloon, Coronary; Cardiac Catheterization; Cardiac Pacin

2004
Effects of combined inhibition of ATP-sensitive potassium channels, nitric oxide, and prostaglandins on hyperemia during moderate exercise.
    Journal of applied physiology (Bethesda, Md. : 1985), 2006, Volume: 100, Issue:5

    Topics: Adenosine Triphosphate; Adult; Enzyme Inhibitors; Exercise; Female; Forearm; Glyburide; Humans; Hype

2006
Transient limb ischemia induces remote preconditioning and remote postconditioning in humans by a K(ATP)-channel dependent mechanism.
    Circulation, 2007, Sep-18, Volume: 116, Issue:12

    Topics: Adult; Aged; Atherosclerosis; Brachial Artery; Endothelium, Vascular; Female; Forearm; Glyburide; He

2007
Transient limb ischemia induces remote preconditioning and remote postconditioning in humans by a K(ATP)-channel dependent mechanism.
    Circulation, 2007, Sep-18, Volume: 116, Issue:12

    Topics: Adult; Aged; Atherosclerosis; Brachial Artery; Endothelium, Vascular; Female; Forearm; Glyburide; He

2007
Transient limb ischemia induces remote preconditioning and remote postconditioning in humans by a K(ATP)-channel dependent mechanism.
    Circulation, 2007, Sep-18, Volume: 116, Issue:12

    Topics: Adult; Aged; Atherosclerosis; Brachial Artery; Endothelium, Vascular; Female; Forearm; Glyburide; He

2007
Transient limb ischemia induces remote preconditioning and remote postconditioning in humans by a K(ATP)-channel dependent mechanism.
    Circulation, 2007, Sep-18, Volume: 116, Issue:12

    Topics: Adult; Aged; Atherosclerosis; Brachial Artery; Endothelium, Vascular; Female; Forearm; Glyburide; He

2007
Transient limb ischemia induces remote preconditioning and remote postconditioning in humans by a K(ATP)-channel dependent mechanism.
    Circulation, 2007, Sep-18, Volume: 116, Issue:12

    Topics: Adult; Aged; Atherosclerosis; Brachial Artery; Endothelium, Vascular; Female; Forearm; Glyburide; He

2007
Transient limb ischemia induces remote preconditioning and remote postconditioning in humans by a K(ATP)-channel dependent mechanism.
    Circulation, 2007, Sep-18, Volume: 116, Issue:12

    Topics: Adult; Aged; Atherosclerosis; Brachial Artery; Endothelium, Vascular; Female; Forearm; Glyburide; He

2007
Transient limb ischemia induces remote preconditioning and remote postconditioning in humans by a K(ATP)-channel dependent mechanism.
    Circulation, 2007, Sep-18, Volume: 116, Issue:12

    Topics: Adult; Aged; Atherosclerosis; Brachial Artery; Endothelium, Vascular; Female; Forearm; Glyburide; He

2007
Transient limb ischemia induces remote preconditioning and remote postconditioning in humans by a K(ATP)-channel dependent mechanism.
    Circulation, 2007, Sep-18, Volume: 116, Issue:12

    Topics: Adult; Aged; Atherosclerosis; Brachial Artery; Endothelium, Vascular; Female; Forearm; Glyburide; He

2007
Transient limb ischemia induces remote preconditioning and remote postconditioning in humans by a K(ATP)-channel dependent mechanism.
    Circulation, 2007, Sep-18, Volume: 116, Issue:12

    Topics: Adult; Aged; Atherosclerosis; Brachial Artery; Endothelium, Vascular; Female; Forearm; Glyburide; He

2007
Transient limb ischemia induces remote preconditioning and remote postconditioning in humans by a K(ATP)-channel dependent mechanism.
    Circulation, 2007, Sep-18, Volume: 116, Issue:12

    Topics: Adult; Aged; Atherosclerosis; Brachial Artery; Endothelium, Vascular; Female; Forearm; Glyburide; He

2007
Transient limb ischemia induces remote preconditioning and remote postconditioning in humans by a K(ATP)-channel dependent mechanism.
    Circulation, 2007, Sep-18, Volume: 116, Issue:12

    Topics: Adult; Aged; Atherosclerosis; Brachial Artery; Endothelium, Vascular; Female; Forearm; Glyburide; He

2007
Transient limb ischemia induces remote preconditioning and remote postconditioning in humans by a K(ATP)-channel dependent mechanism.
    Circulation, 2007, Sep-18, Volume: 116, Issue:12

    Topics: Adult; Aged; Atherosclerosis; Brachial Artery; Endothelium, Vascular; Female; Forearm; Glyburide; He

2007
Transient limb ischemia induces remote preconditioning and remote postconditioning in humans by a K(ATP)-channel dependent mechanism.
    Circulation, 2007, Sep-18, Volume: 116, Issue:12

    Topics: Adult; Aged; Atherosclerosis; Brachial Artery; Endothelium, Vascular; Female; Forearm; Glyburide; He

2007
Transient limb ischemia induces remote preconditioning and remote postconditioning in humans by a K(ATP)-channel dependent mechanism.
    Circulation, 2007, Sep-18, Volume: 116, Issue:12

    Topics: Adult; Aged; Atherosclerosis; Brachial Artery; Endothelium, Vascular; Female; Forearm; Glyburide; He

2007
Transient limb ischemia induces remote preconditioning and remote postconditioning in humans by a K(ATP)-channel dependent mechanism.
    Circulation, 2007, Sep-18, Volume: 116, Issue:12

    Topics: Adult; Aged; Atherosclerosis; Brachial Artery; Endothelium, Vascular; Female; Forearm; Glyburide; He

2007
Transient limb ischemia induces remote preconditioning and remote postconditioning in humans by a K(ATP)-channel dependent mechanism.
    Circulation, 2007, Sep-18, Volume: 116, Issue:12

    Topics: Adult; Aged; Atherosclerosis; Brachial Artery; Endothelium, Vascular; Female; Forearm; Glyburide; He

2007
Adenosine triphosphate-sensitive K+ channels mediate postcardioplegia coronary hyperemia.
    The Journal of thoracic and cardiovascular surgery, 1995, Volume: 110, Issue:4 Pt 1

    Topics: Adenosine Triphosphate; Animals; Coronary Circulation; Coronary Vessels; Glyburide; Guanidines; Hear

1995
Role of K+ATP channels and EDRF in reactive hyperemia in the hindquarters vascular bed of cats.
    The American journal of physiology, 1995, Volume: 269, Issue:5 Pt 2

    Topics: Adamantane; Adenosine Triphosphate; Animals; Arginine; Cats; Glyburide; Hindlimb; Hyperemia; Ischemi

1995
Contribution of potassium channels to active hyperemia of the canine diaphragm.
    Journal of applied physiology (Bethesda, Md. : 1985), 1994, Volume: 76, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Apamin; Blood Gas Analysis; Diaphragm; Dogs; Electric Stimulat

1994
Direct in vivo observation of subendocardial arteriolar response during reactive hyperemia.
    Circulation research, 1995, Volume: 77, Issue:3

    Topics: Adenosine; Animals; Arginine; Arterioles; Coronary Circulation; Coronary Vessels; Dogs; Female; Glyb

1995
Endogenous adenosine mediates coronary vasodilation during exercise after K(ATP)+ channel blockade.
    The Journal of clinical investigation, 1995, Volume: 95, Issue:1

    Topics: Adenosine; Animals; Coronary Circulation; Diastole; Dogs; Glyburide; Guanidines; Hemodynamics; Hyper

1995
Effects of potassium channel blockers on basal vascular tone and reactive hyperemia of canine diaphragm.
    The American journal of physiology, 1994, Volume: 266, Issue:1 Pt 2

    Topics: Animals; Apamin; Arteries; Constriction; Dogs; Glyburide; Hyperemia; Peptides; Potassium Channel Blo

1994
Functional hyperemia in striated muscle is reduced following blockade of ATP-sensitive potassium channels.
    The American journal of physiology, 1996, Volume: 270, Issue:5 Pt 2

    Topics: Adenosine Triphosphate; Animals; Arterioles; Cricetinae; Electric Stimulation; Glyburide; Hyperemia;

1996
KATP channels mediate adenosine-induced hyperemia in retina.
    Investigative ophthalmology & visual science, 1996, Volume: 37, Issue:13

    Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenosine; Adenosine Triphosphate; Adenylyl Cyclases; Animal

1996
Types of potassium channels involved in coronary reactive hyperemia depend on duration of preceding ischemia in rat hearts.
    Life sciences, 1997, Volume: 61, Issue:10

    Topics: 4-Aminopyridine; Adenosine Diphosphate; Animals; Apamin; Charybdotoxin; Glyburide; Hyperemia; In Vit

1997
Myocardial reactive hyperemia in experimental chronic heart failure: evidence for the role of K+ adenosine triphosphate-dependent channels and cyclooxygenase activity.
    Journal of cardiac failure, 1997, Volume: 3, Issue:3

    Topics: Animals; Cardiac Output, Low; Chronic Disease; Coronary Circulation; Cricetinae; Disease Models, Ani

1997
Functional evidence linking potassium channels and afferent nerve-mediated mucosal protection in rat stomach.
    Life sciences, 1997, Volume: 61, Issue:17

    Topics: Animals; Capsaicin; Ethanol; Gastric Acid; Gastric Mucosa; Glyburide; Hyperemia; Male; Neurons, Affe

1997
Vascular ATP-dependent potassium channels, nitric oxide, and human forearm reactive hyperemia.
    Cardiovascular drugs and therapy, 2000, Volume: 14, Issue:1

    Topics: Adenosine Triphosphate; Adult; Analysis of Variance; Enzyme Inhibitors; Female; Forearm; Glyburide;

2000
Mechanisms involved in coronary artery dilatation during respiratory acidosis in the isolated perfused rat heart.
    Basic research in cardiology, 2000, Volume: 95, Issue:2

    Topics: Acidosis, Respiratory; Animals; Carbon Dioxide; Coronary Circulation; Glyburide; GTP-Binding Protein

2000
Glibenclamide enhances cortical spreading depression-associated hyperemia in the rat.
    Neuroreport, 2000, Jul-14, Volume: 11, Issue:10

    Topics: Animals; Cerebral Cortex; Charybdotoxin; Cortical Spreading Depression; Glyburide; Hyperemia; Indome

2000
Microvascular sites and mechanisms responsible for reactive hyperemia in the coronary circulation of the beating canine heart.
    Circulation research, 1992, Volume: 71, Issue:4

    Topics: Adenosine; Adenosine Triphosphate; Animals; Blood Flow Velocity; Coronary Circulation; Coronary Vess

1992
Coronary reactive hyperemia and adenosine-induced vasodilation are mediated partially by a glyburide-sensitive mechanism.
    Pharmacology, 1992, Volume: 44, Issue:2

    Topics: Adenosine; Animals; Coronary Circulation; Dogs; Female; Glyburide; Guinea Pigs; Hyperemia; In Vitro

1992
Blockade of the ATP-sensitive potassium channel modulates reactive hyperemia in the canine coronary circulation.
    Circulation research, 1991, Volume: 69, Issue:3

    Topics: Acetylcholine; Adenosine; Adenosine Triphosphate; Animals; Calcium Channels; Coronary Circulation; D

1991