Page last updated: 2024-10-28

glyburide and Glycosuria

glyburide has been researched along with Glycosuria in 41 studies

Glyburide: An antidiabetic sulfonylurea derivative with actions like those of chlorpropamide
glyburide : An N-sulfonylurea that is acetohexamide in which the acetyl group is replaced by a 2-(5-chloro-2-methoxybenzamido)ethyl group.

Glycosuria: The appearance of an abnormally large amount of GLUCOSE in the urine, such as more than 500 mg/day in adults. It can be due to HYPERGLYCEMIA or genetic defects in renal reabsorption (RENAL GLYCOSURIA).

Research Excerpts

ExcerptRelevanceReference
"The effect of glibenclamide and gliquidone on fasting blood glucose, 24-hour urinary glucose excretion, HbA1 concentrations and on the blood glucose and plasma insulin responses to an oral glucose load were investigated in 11 patients with non-insulin-dependent diabetes mellitus."9.05Glibenclamide and gliquidone in the treatment of non-insulin-dependent diabetes mellitus. ( Groop, L; Nikkilä, K, 1982)
"The effect of glibenclamide and gliquidone on fasting blood glucose, 24-hour urinary glucose excretion, HbA1 concentrations and on the blood glucose and plasma insulin responses to an oral glucose load were investigated in 11 patients with non-insulin-dependent diabetes mellitus."5.05Glibenclamide and gliquidone in the treatment of non-insulin-dependent diabetes mellitus. ( Groop, L; Nikkilä, K, 1982)
"Forty patients with diabetes mellitus and rheumatic disorders (rheumatoid arthritis, osteoarthritis, soft-tissue rheumatism) were included in a double-blind trial with the purpose of investigating whether the concomitant administration of tolmetin and glibenclamide leads to an interaction."5.04Clinical studies of the interaction between tolmetin and glibenclamide. ( Chlud, K; Kaik, B, 1977)
" The body weight changes, blood and urine glucose level changes were monitored with changes on the pancreas weight, and after sacrifice, the histopathological changes of pancreas and the changes of insulin- and glucagon-producing cells were also observed by immunohistochemistry."3.73Anti-diabetic activity of SMK001, a poly herbal formula in streptozotocin induced diabetic rats: therapeutic study. ( Choi, HS; Choi, HY; Kang, SM; Kim, JD; Ku, SK; Seo, BI, 2006)
"Alterations in plasma branched-chain amino acids (valine, isoleucine and leucine) and alanine have been described in patients with insulin-dependent diabetes mellitus who have poor metabolic control."3.66Branched-chain amino acids and alanine as indices of the metabolic control in type 1 (insulin-dependent) and type 2 (non-insulin-dependent) diabetic patients. ( Angiolini, A; Ciavarella, A; Forlani, G; Marchesini, G; Pisi, E; Vannini, P; Zoli, M, 1982)
" Therefore, it is apparent that the addition of glibenclamide to insulin reduces daily insulin dosage and renders a greater uniformity to diurnal blood glucose control, most probably secondary to enhancement of insulin sensitivity."2.68More uniform diurnal blood glucose control and a reduction in daily insulin dosage on addition of glibenclamide to insulin in type 1 diabetes mellitus: role of enhanced insulin sensitivity. ( Birkenholz, M; Kabadi, M; Kabadi, UM; McCoy, S, 1995)
"The test drugs were dosed as follows: 100 mg acarbose (A) three times a day, 1 placebo tablet three times a day, 3."2.67Efficacy of 24-week monotherapy with acarbose, glibenclamide, or placebo in NIDDM patients. The Essen Study. ( Hoffmann, J; Spengler, M, 1994)
"Present treatment of type II diabetes mellitus often fails to normalize post-prandial glucoses."2.66Combined glyburide and insulin therapy in type II diabetes. ( Abraira, C; Lawrence, AM; Reich, A, 1987)
" To determine an optimal glyburide dosage schedule, the effects of glyburide once (every morning) or twice daily and chlorpropamide once daily (every morning) were compared in 18 men with non-insulin-dependent diabetes mellitus in a randomized, double-blind fashion."2.66Once-daily use of glyburide. ( Fajardo, F; Ginier, P; Levin, SR; Madan, S, 1985)
" Post-dose glipizide concentrations were three times higher than those of glibenclamide, due to the incomplete bioavailability of the latter."2.66Pharmacokinetics and metabolic effects of glibenclamide and glipizide in type 2 diabetics. ( Fyhrqvist, F; Groop, L; Groop, PH; Melander, A; Tolppanen, EM; Tötterman, KJ; Wåhlin-Boll, E, 1985)
"The R6/2 transgenic mouse model of Huntington's disease (HD) develops a progressive neurological phenotype that involves severe motor and cognitive dysfunctions."1.33Atypical diabetes associated with inclusion formation in the R6/2 mouse model of Huntington's disease is not improved by treatment with hypoglycaemic agents. ( Hunt, MJ; Morton, AJ, 2005)
"Sixteen patients with type 2 diabetes poorly controlled by glibenclamide (7."1.29Effect of acarbose on blood glucose profiles and plasma 1,5-anhydro-d-glucitol in type 2 diabetes poorly controlled by sulfonylurea therapy. ( Fukasawa, H; Hotta, N; Kakuta, H; Koh, N; Naruse, K; Sakakibara, F; Takeuchi, N; Yamada, K; Yamada, T, 1996)
" Due to the high frequency of side effects it does not seem to be worthwhile to further investigate the therapeutic effect of MPC in a larger number of patients with different dosage regimens."1.25[Effect of methylpyrazole-carboxylic acid on carbohydrate and lipid metabolisms in patients with diabetes mellitus]. ( Hassalacher, Ch; Lang, PD; Vollmar, J; Wahl, P, 1975)

Research

Studies (41)

TimeframeStudies, this research(%)All Research%
pre-199029 (70.73)18.7374
1990's7 (17.07)18.2507
2000's4 (9.76)29.6817
2010's1 (2.44)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Udayakumar, R1
Kasthurirengan, S1
Mariashibu, TS1
Rajesh, M1
Anbazhagan, VR1
Kim, SC1
Ganapathi, A1
Choi, CW1
Gupta, R1
Sharma, AK1
Dobhal, MP1
Sharma, MC1
Gupta, RS1
Hunt, MJ1
Morton, AJ1
Kim, JD1
Kang, SM1
Seo, BI1
Choi, HY1
Choi, HS1
Ku, SK1
Ramesh, B1
Pugalendi, KV1
Sachse, G1
Mäser, E1
Federlin, K1
Groop, L5
Harno, K2
Tolppanen, EM3
Annamala, PT1
Augusti, KT2
Nikkilä, K1
Vannini, P1
Marchesini, G1
Forlani, G1
Angiolini, A1
Ciavarella, A1
Zoli, M1
Pisi, E1
Konstantopoulos, K1
Adamides, S1
Hoffmann, J1
Spengler, M1
Sheela, CG1
Kabadi, UM1
McCoy, S1
Birkenholz, M1
Kabadi, M1
Hotta, N1
Koh, N1
Sakakibara, F1
Naruse, K1
Yamada, T1
Takeuchi, N1
Yamada, K1
Fukasawa, H1
Kakuta, H1
Knick, B1
Thomas, L1
Vollmar, J2
Bauer, G1
Mogensen, EF1
Worm, J1
Mikkelsen, BO1
Chlud, K1
Kaik, B1
Lang, PD1
Wahl, P1
Hassalacher, Ch1
Wildenhoff, KE1
Boyd, K1
Rogers, C1
Boreham, C1
Andrews, WJ1
Hadden, DR1
Velussi, M1
Cernigoi, AM1
Viezzoli, L1
Caffau, C1
Reich, A1
Abraira, C1
Lawrence, AM1
Welle, S1
Nair, KS1
Lockwood, D1
Salo, S1
Balabolkin, MI1
Nedosugova, LV1
Nikkilä, EA1
Pelkonen, R1
Ginier, P1
Madan, S1
Fajardo, F1
Levin, SR1
Wåhlin-Boll, E1
Groop, PH1
Tötterman, KJ1
Melander, A1
Fyhrqvist, F1
Fähndrich, W1
Liebermeister, H1
Schmitt, H1
Daweke, H1
De Leeuw, I1
De Baere, H1
Decraene, P1
Lemmens, P1
Verhaegen, H1
Sweet, RD1
Tattersall, RB1
Beringer, A1
Happ, J1
Beyer, J2
Nest, E1
Fröhlich, A1
Althoff, PH1
Schöffling, K2
Parodi, FA1
Zöllner, N1
Dörfler, H1
Wolfram, G1
Blohmé, G1
Mehnert, H1
Ewald, W1
Haupt, E1
Wicklmayr, M1
Nemeth, N1
Burns, FH1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Pilot, Open-label Study to Evaluate the Effects of a Prostate Health Formulation on Scores Attained From the International Prostate Symptom Score (I-PSS) Questionnaire Among Overall Healthy Male Participants Who Report Lower Urinary Tract Complaints[NCT02886832]30 participants (Anticipated)Interventional2016-09-21Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

17 trials available for glyburide and Glycosuria

ArticleYear
[Combination therapy with insulin and sulfonylurea in secondary failure of sulfonylurea therapy].
    Deutsche medizinische Wochenschrift (1946), 1984, Mar-16, Volume: 109, Issue:11

    Topics: Aged; Blood Glucose; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Glyburide; Glycat

1984
The combination of insulin and sulphonylurea in the treatment of secondary drug failure in patients with type II diabetes.
    Acta endocrinologica, 1984, Volume: 106, Issue:1

    Topics: Adult; Aged; Blood Glucose; C-Peptide; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Drug The

1984
Glibenclamide and gliquidone in the treatment of non-insulin-dependent diabetes mellitus.
    Acta medica Scandinavica, 1982, Volume: 211, Issue:1-2

    Topics: Aged; Blood Glucose; Clinical Trials as Topic; Diabetes Mellitus; Female; Glyburide; Glycated Hemogl

1982
Efficacy of 24-week monotherapy with acarbose, glibenclamide, or placebo in NIDDM patients. The Essen Study.
    Diabetes care, 1994, Volume: 17, Issue:6

    Topics: Acarbose; Adult; Aged; Blood Glucose; Cholesterol; Cholesterol, HDL; Diabetes Mellitus, Type 2; Diet

1994
More uniform diurnal blood glucose control and a reduction in daily insulin dosage on addition of glibenclamide to insulin in type 1 diabetes mellitus: role of enhanced insulin sensitivity.
    Diabetic medicine : a journal of the British Diabetic Association, 1995, Volume: 12, Issue:10

    Topics: Adult; Aged; Blood Glucose; Body Weight; C-Peptide; Cholesterol; Circadian Rhythm; Cross-Over Studie

1995
[The effect of metipranolol on the carbohydrate metabolism in diabetics treated with glibenclamide (author's transl)].
    Medizinische Klinik, 1979, Mar-02, Volume: 74, Issue:9

    Topics: Adult; Aged; Blood Glucose; Carbohydrate Metabolism; Clinical Trials as Topic; Diabetes Mellitus; Do

1979
Clinical comparison between glibornuride (Glutril) and glibenclamide in maturity-onset diabetes: a controlled double-blind trial.
    Current therapeutic research, clinical and experimental, 1976, Volume: 19, Issue:6

    Topics: Aged; Blood Glucose; Clinical Trials as Topic; Diabetes Mellitus; Dose-Response Relationship, Drug;

1976
Clinical studies of the interaction between tolmetin and glibenclamide.
    International journal of clinical pharmacology and biopharmacy, 1977, Volume: 15, Issue:9

    Topics: Adult; Aged; Blood Glucose; Diabetes Complications; Diabetes Mellitus; Drug Interactions; Female; Gl

1977
Insulin, glibenclamide or metformin treatment for non insulin dependent diabetes: heterogenous responses of standard measures of insulin action and insulin secretion before and after differing hypoglycaemic therapy.
    Diabetes research (Edinburgh, Scotland), 1992, Volume: 19, Issue:2

    Topics: Blood Glucose; Body Mass Index; C-Peptide; Diabetes Mellitus, Type 2; Glucose Clamp Technique; Glybu

1992
Combined glyburide and insulin therapy in type II diabetes.
    Diabetes research (Edinburgh, Scotland), 1987, Volume: 6, Issue:2

    Topics: Adult; Aged; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Evaluat

1987
Combination of two sulfonylureas. Does it make sense.
    Diabetes care, 1988, Volume: 11, Issue:9

    Topics: Blood Glucose; Clinical Trials as Topic; Diabetes Mellitus; Diabetes Mellitus, Type 2; Drug Therapy,

1988
Transient effect of the combination of insulin and sulfonylurea (glibenclamide) on glycemic control in non-insulin dependent diabetics poorly controlled with insulin alone.
    Acta medica Scandinavica, 1985, Volume: 217, Issue:1

    Topics: Blood Glucose; Body Weight; C-Peptide; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Double-B

1985
Once-daily use of glyburide.
    The American journal of medicine, 1985, Sep-20, Volume: 79, Issue:3B

    Topics: Blood Glucose; Body Weight; Chlorpropamide; Diabetes Mellitus, Type 2; Drug Administration Schedule;

1985
Pharmacokinetics and metabolic effects of glibenclamide and glipizide in type 2 diabetics.
    European journal of clinical pharmacology, 1985, Volume: 28, Issue:6

    Topics: Aged; Blood Glucose; Body Weight; C-Peptide; Diabetes Mellitus, Type 2; Double-Blind Method; Erythro

1985
[Blood sugar, serum insulin, nonesterified fatty acids and somatotropin in daily profile in adult diabetics under monotherapy with various sulfonylureas].
    Arzneimittel-Forschung, 1974, Volume: 24, Issue:8

    Topics: Blood Glucose; Body Weight; Diabetes Mellitus; Diet, Diabetic; Fatty Acids, Nonesterified; Glyburide

1974
[Clinical testing of a sulphonylurea derivative, glibornuride].
    Deutsche medizinische Wochenschrift (1946), 1972, Jul-21, Volume: 97, Issue:29

    Topics: Adult; Aged; Biguanides; Blood Glucose; Clinical Trials as Topic; Diabetes Mellitus; Diet Therapy; F

1972
[Therapy of diabetes in adults using Glibornurid. Results and clinical studies].
    Deutsche medizinische Wochenschrift (1946), 1973, May-04, Volume: 98, Issue:18

    Topics: Aged; Blood Glucose; Body Weight; Camphanes; Clinical Trials as Topic; Diabetes Mellitus; Drug Hyper

1973

Other Studies

24 other studies available for glyburide and Glycosuria

ArticleYear
Hypoglycaemic and hypolipidaemic effects of Withania somnifera root and leaf extracts on alloxan-induced diabetic rats.
    International journal of molecular sciences, 2009, May-20, Volume: 10, Issue:5

    Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glyburide; Glycosuria; Hemoglobins

2009
Antidiabetic and antioxidant potential of β-sitosterol in streptozotocin-induced experimental hyperglycemia.
    Journal of diabetes, 2011, Volume: 3, Issue:1

    Topics: Animals; Antioxidants; Blood Glucose; Catalase; Diabetes Mellitus, Experimental; Dose-Response Relat

2011
Atypical diabetes associated with inclusion formation in the R6/2 mouse model of Huntington's disease is not improved by treatment with hypoglycaemic agents.
    Experimental brain research, 2005, Volume: 166, Issue:2

    Topics: Administration, Oral; Animals; Behavior, Animal; Diabetes Mellitus; Disease Models, Animal; Exocytos

2005
Anti-diabetic activity of SMK001, a poly herbal formula in streptozotocin induced diabetic rats: therapeutic study.
    Biological & pharmaceutical bulletin, 2006, Volume: 29, Issue:3

    Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Dose-Response Relationship, Dr

2006
Antihyperglycemic effect of umbelliferone in streptozotocin-diabetic rats.
    Journal of medicinal food, 2006,Winter, Volume: 9, Issue:4

    Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Fructose-Bisphosphatase; Glucokinase; Gluco

2006
Studies on the biochemical effects of glibenclamide on alloxan diabetic rabbits.
    Experientia, 1980, Apr-15, Volume: 36, Issue:4

    Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Glyburide; Glycosuria; Lipid M

1980
Branched-chain amino acids and alanine as indices of the metabolic control in type 1 (insulin-dependent) and type 2 (non-insulin-dependent) diabetic patients.
    Diabetologia, 1982, Volume: 22, Issue:3

    Topics: Alanine; Amino Acids, Branched-Chain; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Type 1; F

1982
A case of diabetes following tibolone therapy.
    Maturitas, 1994, Volume: 19, Issue:1

    Topics: Anabolic Agents; Blood Glucose; Climacteric; Combined Modality Therapy; Diabetes Mellitus, Type 2; D

1994
Antiperoxide effect of S-allyl cysteine sulfoxide, an insulin secretagogue, in diabetic rats.
    Experientia, 1996, Feb-15, Volume: 52, Issue:2

    Topics: Animals; Blood Glucose; Catalase; Cysteine; Diabetes Mellitus, Experimental; Garlic; Glucose; Glybur

1996
Effect of acarbose on blood glucose profiles and plasma 1,5-anhydro-d-glucitol in type 2 diabetes poorly controlled by sulfonylurea therapy.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 1996, Volume: 50, Issue:6-7

    Topics: Acarbose; Aged; Blood Glucose; Deoxyglucose; Diabetes Mellitus, Type 2; Female; Fructosamine; Glucos

1996
[Effect of methylpyrazole-carboxylic acid on carbohydrate and lipid metabolisms in patients with diabetes mellitus].
    Arzneimittel-Forschung, 1975, Volume: 25, Issue:1

    Topics: Aged; Blood Glucose; Carbutamide; Cholesterol; Diabetes Mellitus; Drug Evaluation; Fatty Acids, None

1975
Blood ketone body disappearance rate in diabetics and normals after rapid infusion of dl-3-hydroxybutyrate. Studies before and after diabetic treatment.
    Acta medica Scandinavica, 1976, Volume: 200, Issue:1-2

    Topics: Acetoacetates; Adolescent; Adult; Aged; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Type 1;

1976
[Median-term (4 months) treatment with glibenclamide + metformin substituting for glibenclamide + fenformin lowers the lacticemia levels in type-2 diabetics (NIDDM)].
    La Clinica terapeutica, 1992, Volume: 141, Issue:12

    Topics: Aged; Blood Glucose; Diabetes Mellitus, Type 2; Drug Evaluation; Drug Therapy, Combination; Female;

1992
Effect of a sulfonylurea and insulin on energy expenditure in type II diabetes mellitus.
    The Journal of clinical endocrinology and metabolism, 1988, Volume: 66, Issue:3

    Topics: Blood Glucose; Blood Urea Nitrogen; C-Peptide; Diabetes Mellitus; Diabetes Mellitus, Type 2; Energy

1988
[Effect of long-term therapy with sulfanylurea preparations on the relation of insulin secretion and the insulin-binding capacity of its receptors].
    Terapevticheskii arkhiv, 1988, Volume: 60, Issue:12

    Topics: Blood Glucose; Chlorpropamide; Diabetes Mellitus, Type 2; Drug Evaluation; Female; Gliclazide; Gluco

1988
[A comparison of intravenous tolbutamide and insulin administration during and after operation in patients with maturity-onset diabetes (author's transl)].
    Deutsche medizinische Wochenschrift (1946), 1974, Jan-25, Volume: 99, Issue:4

    Topics: Administration, Oral; Age Factors; Aged; Anesthesia, General; Blood Glucose; Carbohydrates; Carbutam

1974
An open comparative study of the efficacy and tolerance of a new antidiabetic agent: glipizide.
    Diabetologia, 1973

    Topics: Blood Glucose; Chlorpropamide; Cyclohexanes; Diabetes Mellitus; Diet, Diabetic; Female; Glyburide; G

1973
A dermatosis specifically associated with a tumour of pancreatic alpha cells.
    The British journal of dermatology, 1974, Volume: 90, Issue:3

    Topics: Blister; Blood Glucose; Body Weight; Diabetes Complications; Female; Glucagon; Glucose; Glucose Tole

1974
Mild familial diabetes with dominant inheritance.
    The Quarterly journal of medicine, 1974, Volume: 43, Issue:170

    Topics: Acetohexamide; Adolescent; Adult; Aged; Blood Glucose; Carbohydrates; Child; Chlorpropamide; Diabete

1974
[The following of a diabetic patient treated by Euglucan].
    Journees annuelles de diabetologie de l'Hotel-Dieu, 1972, Volume: 13, Issue:0

    Topics: Blood Glucose; Diabetes Mellitus; Follow-Up Studies; Glyburide; Glycosuria; Humans

1972
[Oral antidiabetic therapy with delayed-action glibenclamide and phenformin in fixed combination].
    Minerva medica, 1974, Sep-01, Volume: 65, Issue:60

    Topics: Adult; Aged; Blood Glucose; Carbutamide; Cholesterol; Delayed-Action Preparations; Diabetes Mellitus

1974
[Role of glibenclamide in the therapy of diabetes].
    Minerva medica, 1972, Apr-14, Volume: 63, Issue:28

    Topics: Adult; Chlorpropamide; Diabetes Mellitus; Evaluation Studies as Topic; Glyburide; Glycosuria; Humans

1972
[Glibenclamide--a better antidiabetic agent?].
    Lakartidningen, 1972, Dec-20, Volume: 69, Issue:52

    Topics: Aged; Blood Glucose; Body Weight; Chlorpropamide; Cholesterol; Diabetes Mellitus; Female; Glyburide;

1972
Glibenclamide--experience at Royal Prince Alfred Hospital 1967-70.
    Australian and New Zealand journal of medicine, 1971, Volume: 1

    Topics: Adult; Aged; Blood Glucose; Diabetes Mellitus; Glyburide; Glycosuria; Humans; Hypoglycemic Agents; M

1971