glyburide has been researched along with Genetic Predisposition in 10 studies
Glyburide: An antidiabetic sulfonylurea derivative with actions like those of chlorpropamide
glyburide : An N-sulfonylurea that is acetohexamide in which the acetyl group is replaced by a 2-(5-chloro-2-methoxybenzamido)ethyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The glyburide dose was determined by the presence of the risk allele, among other factors." | 2.78 | The R230C variant of the ATP binding cassette protein A1 (ABCA1) gene is associated with a decreased response to glyburide therapy in patients with type 2 diabetes mellitus. ( Aguilar-Salinas, CA; Cobos-Bonilla, M; Medina-Santillan, R; Mehta, R; Muñoz-Hernandez, LL; Ordoñez-Sanchez, ML; Ramírez-Márquez, MR; Tusie-Luna, MT, 2013) |
| "At 26 wk, edema was recorded in 48 of the patients (14%) treated with ragaglitazar, and Cox regression analyses identified the common Pro12Ala variant of the PPARG gene as biologically the most important risk factor (hazard ratio 4." | 2.72 | The Pro12Ala variant of the PPARG gene is a risk factor for peroxisome proliferator-activated receptor-gamma/alpha agonist-induced edema in type 2 diabetic patients. ( Anant, M; Ekstrøm, CT; Hansen, L; Reinhardt, RR; Tabanera Y Palacios, R; Wassermann, K, 2006) |
| " Because insulin resistance may contribute to spontaneous hypertension in rats, we sought to determine if long-term administration of glyburide (5 mg/kg per day by diet, age 5 weeks to 5 months) would lower blood pressure in male and female stroke-prone spontaneously hypertensive rats." | 1.29 | Sex-specific effects of an insulin secretagogue in stroke-prone hypertensive rats. ( Johnson, BA; Peuler, JD; Phare, SM; Sowers, JR, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (20.00) | 18.2507 |
| 2000's | 2 (20.00) | 29.6817 |
| 2010's | 6 (60.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kandasamy, B | 1 |
| Shyng, SL | 1 |
| Phani, NM | 1 |
| Vohra, M | 1 |
| Adhikari, P | 1 |
| Nagri, SK | 1 |
| Shashikiran, U | 1 |
| D'Souza, SC | 1 |
| Kalluri, PRR | 1 |
| Satyamoorthy, K | 1 |
| Rai, PS | 1 |
| Ma, A | 1 |
| Gurnasinghani, S | 1 |
| Kirk, EP | 1 |
| McClenaghan, C | 1 |
| Singh, GK | 1 |
| Grange, DK | 1 |
| Pandit, C | 1 |
| Zhu, Y | 1 |
| Roscioli, T | 1 |
| Elakis, G | 1 |
| Buckley, M | 1 |
| Mehta, B | 1 |
| Roberts, P | 1 |
| Mervis, J | 1 |
| Biggin, A | 1 |
| Nichols, CG | 1 |
| Hashimoto, Y | 1 |
| Dateki, S | 1 |
| Hirose, M | 1 |
| Satomura, K | 1 |
| Sawada, H | 1 |
| Mizuno, H | 1 |
| Sugihara, S | 1 |
| Maruyama, K | 1 |
| Urakami, T | 1 |
| Sugawara, H | 1 |
| Shirai, K | 1 |
| Yorifuji, T | 1 |
| Wu, D | 1 |
| Ren, P | 1 |
| Zheng, Y | 1 |
| Zhang, L | 1 |
| Xu, G | 1 |
| Xie, W | 1 |
| Lloyd, EE | 1 |
| Zhang, S | 1 |
| Zhang, Q | 1 |
| Curci, JA | 1 |
| Coselli, JS | 1 |
| Milewicz, DM | 1 |
| Shen, YH | 1 |
| LeMaire, SA | 1 |
| Aguilar-Salinas, CA | 1 |
| Muñoz-Hernandez, LL | 1 |
| Cobos-Bonilla, M | 1 |
| Ramírez-Márquez, MR | 1 |
| Ordoñez-Sanchez, ML | 1 |
| Mehta, R | 1 |
| Medina-Santillan, R | 1 |
| Tusie-Luna, MT | 1 |
| Hansen, L | 1 |
| Ekstrøm, CT | 1 |
| Tabanera Y Palacios, R | 1 |
| Anant, M | 1 |
| Wassermann, K | 1 |
| Reinhardt, RR | 1 |
| Shimomura, K | 1 |
| Hörster, F | 1 |
| de Wet, H | 1 |
| Flanagan, SE | 1 |
| Ellard, S | 1 |
| Hattersley, AT | 1 |
| Wolf, NI | 1 |
| Ashcroft, F | 1 |
| Ebinger, F | 1 |
| Peuler, JD | 1 |
| Johnson, BA | 1 |
| Phare, SM | 1 |
| Sowers, JR | 1 |
| Jovanovic, A | 1 |
| Jovanovic, S | 1 |
| Carrasco, AJ | 1 |
| Terzic, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of the R230C Variant of the ATP-binding Cassette Transporter A1 (ABCA1) Gene on the Response to Treatment With Glibenclamide in Patients With Type 2 Diabetes Mellitus[NCT01456650] | Phase 4 | 85 participants (Actual) | Interventional | 2011-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for glyburide and Genetic Predisposition
| Article | Year |
|---|---|
The R230C variant of the ATP binding cassette protein A1 (ABCA1) gene is associated with a decreased response to glyburide therapy in patients with type 2 diabetes mellitus.
Topics: Adult; Aged; Amino Acid Substitution; Arginine; ATP Binding Cassette Transporter 1; ATP-Binding Cass | 2013 |
The Pro12Ala variant of the PPARG gene is a risk factor for peroxisome proliferator-activated receptor-gamma/alpha agonist-induced edema in type 2 diabetic patients.
Topics: Diabetes Mellitus, Type 2; DNA; Edema; Female; Genetic Predisposition to Disease; Genotype; Glyburid | 2006 |
8 other studies available for glyburide and Genetic Predisposition
| Article | Year |
|---|---|
Methods for Characterizing Disease-Associated ATP-Sensitive Potassium Channel Mutations.
Topics: Animals; Blotting, Western; Chlorocebus aethiops; Congenital Hyperinsulinism; COS Cells; Diabetes Me | 2018 |
Genetic Variants Identified from GWAS for Predisposition to Type 2 Diabetes Predict Sulfonylurea Drug Response.
Topics: Adult; Aged; Diabetes Mellitus, Type 2; Female; Genetic Predisposition to Disease; Genome-Wide Assoc | 2017 |
Glibenclamide treatment in a Cantú syndrome patient with a pathogenic ABCC9 gain-of-function variant: Initial experience.
Topics: Alleles; Cardiomegaly; Echocardiography; Female; Gain of Function Mutation; Genetic Association Stud | 2019 |
Molecular and clinical features of K
Topics: Amino Acid Substitution; Congenital Hyperinsulinism; Diabetes Mellitus; DNA Mutational Analysis; Dru | 2017 |
NLRP3 (Nucleotide Oligomerization Domain-Like Receptor Family, Pyrin Domain Containing 3)-Caspase-1 Inflammasome Degrades Contractile Proteins: Implications for Aortic Biomechanical Dysfunction and Aneurysm and Dissection Formation.
Topics: Aged; Angiotensin II; Animals; Aorta, Abdominal; Aorta, Thoracic; Aortic Aneurysm, Abdominal; Aortic | 2017 |
A novel mutation causing DEND syndrome: a treatable channelopathy of pancreas and brain.
Topics: Animals; Anticonvulsants; Cell Membrane; Child, Preschool; Developmental Disabilities; Diabetes Mell | 2007 |
Sex-specific effects of an insulin secretagogue in stroke-prone hypertensive rats.
Topics: Animals; Aorta; Body Weight; Cerebrovascular Disorders; Female; Genetic Predisposition to Disease; G | 1993 |
Acquired resistance of a mammalian cell line to hypoxia-reoxygenation through cotransfection of Kir6.2 and SUR1 clones.
Topics: Animals; Calcium; COS Cells; Genetic Predisposition to Disease; Glyburide; Glycosyltransferases; Hyp | 1998 |